SIMILAR PATTERNS OF AMINO ACIDS FOR 5C0O_H_SAMH301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9z EXCINUCLEASE UVRABC
COMPONENT UVRB

([Bacillus]
caldotenax) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		4 GLY A 217
GLU A 239
HIS A 240
ASP A 228
 None
 1.18A 5c0oH-1d9zA:
4.7		 5c0oH-1d9zA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II

(Synechocystis
sp. PCC 6803) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 267
GLY A 282
GLU A 318
HIS A 307
 None
 1.22A 5c0oH-1e5mA:
undetectable		 5c0oH-1e5mA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		4 THR C 295
GLU C 353
HIS C 350
ASP C 293
 None
 1.20A 5c0oH-1h2tC:
undetectable		 5c0oH-1h2tC:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE

(Pyrococcus
horikoshii) 		PF00857
(Isochorismatase) 		4 THR A  50
GLY A 105
GLU A 101
ASP A  10
 None
None
ZN  A 400 ( 4.1A)
None
 1.15A 5c0oH-1im5A:
4.1		 5c0oH-1im5A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwm PROCARBOXYPEPTIDASE
B

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		4 THR A 164
GLU A  72
HIS A 196
ASP A  41
 None
ZN  A 400 (-2.1A)
ZN  A 400 (-3.3A)
None
 1.16A 5c0oH-1kwmA:
undetectable		 5c0oH-1kwmA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE

(Haemophilus
influenzae) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 THR A  56
GLY A  27
HIS A  74
ASP A  52
 None
EPU  A 598 (-3.7A)
None
None
 1.25A 5c0oH-1p31A:
4.8		 5c0oH-1p31A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1d APYRASE

(Homo sapiens) 		PF06079
(Apyrase) 		4 THR A 114
GLY A 141
GLU A 145
ASP A 111
 None
None
GP2  A4001 ( 2.7A)
None
 0.97A 5c0oH-1s1dA:
undetectable		 5c0oH-1s1dA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um4 ANTIBODY 21H3 H
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR H  88
GLY H  16
GLU H  83
ASP H  91
 None
 1.26A 5c0oH-1um4H:
undetectable		 5c0oH-1um4H:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		4 THR A  77
GLY A  79
GLU A 197
HIS A 200
 None
None
FE  A1292 ( 2.1A)
FE  A1293 (-3.2A)
 1.15A 5c0oH-1uzrA:
undetectable		 5c0oH-1uzrA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6f ARYLAMINE
N-ACETYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF00797
(Acetyltransf_2) 		4 THR A 234
GLY A 232
GLU A 152
HIS A 151
 None
 1.04A 5c0oH-1w6fA:
undetectable		 5c0oH-1w6fA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9z VP9

(Banna virus) 		PF08978
(Reoviridae_Vp9) 		4 THR A 115
GLY A 126
GLU A 149
HIS A 150
 None
 1.21A 5c0oH-1w9zA:
undetectable		 5c0oH-1w9zA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B) 		4 THR A 277
GLY A  42
HIS A 112
ASP A  44
 None
None
FE  A 401 ( 3.3A)
None
 1.22A 5c0oH-1wraA:
undetectable		 5c0oH-1wraA:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b25 HYPOTHETICAL PROTEIN

(Homo sapiens) 		PF08704
(GCD14) 		5 THR A  87
GLY A 116
GLU A 135
HIS A 140
ASP A 192
 SAM  A 601 (-3.7A)
SAM  A 601 (-3.5A)
SAM  A 601 (-2.9A)
SAM  A 601 (-4.0A)
SAM  A 601 (-3.5A)
 0.76A 5c0oH-2b25A:
25.7		 5c0oH-2b25A:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4v RNA EDITING COMPLEX
PROTEIN MP57

(Trypanosoma
brucei) 		PF01909
(NTP_transf_2)
PF03828
(PAP_assoc) 		4 THR A 364
GLY A 367
HIS A 294
ASP A 362
 None
 1.21A 5c0oH-2b4vA:
undetectable		 5c0oH-2b4vA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA

(Escherichia
coli) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 GLY A1311
GLU A1144
HIS A1147
ASP A1314
 None
 1.23A 5c0oH-2bruA:
6.0		 5c0oH-2bruA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg3 PROBABLE THIOSULFATE
SULFURTRANSFERASE

(Thermus
thermophilus) 		PF00581
(Rhodanese) 		4 THR A  57
GLY A  59
GLU A 105
HIS A  28
 None
 1.22A 5c0oH-2eg3A:
undetectable		 5c0oH-2eg3A:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 GLY A 239
GLU A 271
HIS A 275
ASP A 244
 None
 1.26A 5c0oH-2eklA:
7.2		 5c0oH-2eklA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuv PHOSPHOGLUCOMUTASE

(Salmonella
enterica) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 THR A  87
GLY A 237
HIS A 147
ASP A  86
 None
 1.20A 5c0oH-2fuvA:
undetectable		 5c0oH-2fuvA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Staphylococcus
aureus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 264
GLY A 279
GLU A 315
HIS A 304
 None
 1.13A 5c0oH-2gqdA:
undetectable		 5c0oH-2gqdA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1n OLIGOENDOPEPTIDASE F

(Geobacillus
stearothermophilus) 		PF01432
(Peptidase_M3) 		4 GLY A 349
GLU A 391
HIS A 356
ASP A 416
 None
None
ZN  A 601 (-3.3A)
None
 0.82A 5c0oH-2h1nA:
undetectable		 5c0oH-2h1nA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1

(Methanosarcina
barkeri) 		PF12176
(MtaB) 		4 THR A  18
GLY A  20
GLU A 345
ASP A 349
 None
 1.22A 5c0oH-2i2xA:
undetectable		 5c0oH-2i2xA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou MAJOR TROPISM
DETERMINANT P1

(Bordetella
virus BPP1) 		no annotation 4 THR A  41
GLY A  43
GLU A  24
ASP A  38
 None
 0.98A 5c0oH-2iouA:
undetectable		 5c0oH-2iouA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kho HEAT SHOCK PROTEIN
70

(Escherichia
coli) 		PF00012
(HSP70) 		4 THR A  12
GLY A 196
GLU A 230
HIS A 226
 None
 1.02A 5c0oH-2khoA:
undetectable		 5c0oH-2khoA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lr5 MICASIN

(Microsporum
canis) 		PF01097
(Defensin_2) 		4 THR A  34
GLY A  23
GLU A  10
HIS A  14
 None
 0.91A 5c0oH-2lr5A:
undetectable		 5c0oH-2lr5A:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		4 THR A 222
GLY A 247
GLU A 237
ASP A 230
 None
 0.92A 5c0oH-2o5vA:
undetectable		 5c0oH-2o5vA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		4 THR A 222
GLY A 247
GLU A 238
ASP A 230
 None
 1.23A 5c0oH-2o5vA:
undetectable		 5c0oH-2o5vA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Aspergillus
oryzae) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 THR A 277
GLY A 279
HIS A 310
ASP A 109
 None
 1.15A 5c0oH-2ps2A:
2.2		 5c0oH-2ps2A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwh SUCROSE ISOMERASE

([Pseudomonas]
mesoacidophila) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 THR A 432
GLY A 430
GLU A  36
ASP A  22
 None
None
None
CA  A7001 (-3.0A)
 1.00A 5c0oH-2pwhA:
undetectable		 5c0oH-2pwhA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qed HYDROXYACYLGLUTATHIO
NE HYDROLASE

(Salmonella
enterica) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		4 THR A 128
GLY A 126
GLU A  79
HIS A  54
 None
 0.97A 5c0oH-2qedA:
undetectable		 5c0oH-2qedA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qj8 MLR6093 PROTEIN

(Mesorhizobium
japonicum) 		PF04952
(AstE_AspA) 		4 THR A 145
GLY A 208
GLU A 205
HIS A 140
 None
 1.25A 5c0oH-2qj8A:
undetectable		 5c0oH-2qj8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlw RHAU

(Rhizobium
leguminosarum) 		PF05336
(rhaM) 		4 THR A  65
GLY A  39
GLU A   4
HIS A   6
 None
 1.25A 5c0oH-2qlwA:
undetectable		 5c0oH-2qlwA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlx L-RHAMNOSE
MUTAROTASE

(Rhizobium
leguminosarum) 		PF05336
(rhaM) 		4 THR A  65
GLY A  39
GLU A   4
HIS A   6
 None
 1.20A 5c0oH-2qlxA:
undetectable		 5c0oH-2qlxA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjt BETA-KETOACYL-ACP
SYNTHASE II

(Streptococcus
pneumoniae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 263
GLY A 278
GLU A 314
HIS A 303
 None
 1.22A 5c0oH-2rjtA:
undetectable		 5c0oH-2rjtA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x36 LON PROTEASE
HOMOLOG,
MITOCHONDRIAL

(Homo sapiens) 		PF05362
(Lon_C) 		4 THR A 777
GLY A 767
GLU A 781
HIS A 843
 None
 0.86A 5c0oH-2x36A:
2.1		 5c0oH-2x36A:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9x SELENOCYSTEINE LYASE

(Rattus
norvegicus) 		PF00266
(Aminotran_5) 		4 THR A 265
GLY A 260
GLU A 234
ASP A 239
 None
 0.96A 5c0oH-3a9xA:
2.6		 5c0oH-3a9xA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahm OLIGOPEPTIDASE

(Geobacillus sp.
MO-1) 		no annotation 4 GLY A 349
GLU A 391
HIS A 356
ASP A 416
 None
None
ZN  A 565 (-3.4A)
None
 0.89A 5c0oH-3ahmA:
undetectable		 5c0oH-3ahmA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clq UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF06545
(DUF1116) 		4 GLY A 250
GLU A 242
HIS A 244
ASP A 283
 None
 1.17A 5c0oH-3clqA:
undetectable		 5c0oH-3clqA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		PF00632
(HECT) 		4 GLY A4302
GLU A4147
HIS A4339
ASP A4145
 NA  A5001 ( 4.9A)
None
None
None
 1.10A 5c0oH-3g1nA:
undetectable		 5c0oH-3g1nA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goc ENDONUCLEASE V

(Streptomyces
avermitilis) 		PF04493
(Endonuclease_5) 		4 THR A 213
GLY A  44
GLU A  93
ASP A 114
 None
None
None
MG  A 302 (-3.9A)
 1.09A 5c0oH-3gocA:
undetectable		 5c0oH-3gocA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 THR C 277
GLY C 272
GLU C 246
ASP C 251
 None
 1.14A 5c0oH-3gzdC:
3.2		 5c0oH-3gzdC:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsi PHOSPHATIDYLSERINE
SYNTHASE

(Haemophilus
influenzae) 		PF13091
(PLDc_2) 		4 THR A 275
GLY A 364
GLU A 389
HIS A 139
 None
 1.16A 5c0oH-3hsiA:
2.1		 5c0oH-3hsiA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0z PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Streptococcus
pneumoniae) 		PF01380
(SIS) 		4 THR A 289
GLY A 287
GLU A 328
ASP A 318
 None
 0.69A 5c0oH-3i0zA:
2.7		 5c0oH-3i0zA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3w PHOSPHOGLUCOSAMINE
MUTASE

(Francisella
tularensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 THR A 283
GLY A 279
HIS A 326
ASP A 258
 None
None
SEP  A 101 ( 3.7A)
None
 0.95A 5c0oH-3i3wA:
undetectable		 5c0oH-3i3wA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgx PUTATIVE P450
MONOOXYGENASE

(Amycolatopsis
balhimycina) 		PF00067
(p450) 		4 THR A 139
GLY A 142
HIS A 249
ASP A 136
 None
None
GOL  A 401 (-4.3A)
None
 1.08A 5c0oH-3mgxA:
undetectable		 5c0oH-3mgxA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672

(Caulobacter
vibrioides) 		PF01979
(Amidohydro_1) 		4 THR A 301
GLY A 305
GLU A 312
ASP A 318
 None
None
None
M3R  A 430 (-3.8A)
 1.04A 5c0oH-3mtwA:
undetectable		 5c0oH-3mtwA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE

(Ruegeria sp.
TM1040) 		PF04952
(AstE_AspA) 		4 THR A 149
GLY A 213
GLU A 209
HIS A 144
 None
 1.18A 5c0oH-3na6A:
undetectable		 5c0oH-3na6A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 263
GLY A 278
GLU A 314
HIS A 303
 None
 1.16A 5c0oH-3o04A:
undetectable		 5c0oH-3o04A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 264
GLY A 277
GLU A 310
HIS A 299
 None
 1.14A 5c0oH-3oytA:
undetectable		 5c0oH-3oytA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbd 3-DEHYDROQUINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01761
(DHQ_synthase) 		4 THR A 110
GLY A 106
HIS A 265
ASP A 111
 None
NAD  A 400 (-3.1A)
None
NAD  A 400 (-3.1A)
 1.25A 5c0oH-3qbdA:
5.1		 5c0oH-3qbdA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnk PUTATIVE LIPOPROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 THR A 332
GLY A 334
HIS A 350
ASP A 329
 None
 1.19A 5c0oH-3qnkA:
undetectable		 5c0oH-3qnkA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsq CAPSID POLYPROTEIN

(Mamastrovirus 1) 		PF12226
(Astro_capsid_p) 		4 THR A 544
GLY A 585
GLU A 499
ASP A 517
 None
 1.06A 5c0oH-3qsqA:
undetectable		 5c0oH-3qsqA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0f BETA-KETOACYL
SYNTHASE

(Brucella
abortus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 261
GLY A 274
GLU A 307
HIS A 296
 None
 1.05A 5c0oH-3u0fA:
undetectable		 5c0oH-3u0fA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgf ARYLAMINE
N-ACETYLTRANSFERASE
NAT

(Mycobacterium
tuberculosis) 		PF00797
(Acetyltransf_2) 		4 THR A 234
GLY A 232
GLU A 152
HIS A 151
 None
 1.10A 5c0oH-4bgfA:
undetectable		 5c0oH-4bgfA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5t MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN

(Labrenzia
alexandrii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 THR A  89
GLY A  92
GLU A 272
ASP A  87
 None
 1.27A 5c0oH-4e5tA:
undetectable		 5c0oH-4e5tA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A  55
GLY A  57
HIS A 111
ASP A 113
 None
None
None
EDO  A 408 (-3.3A)
 1.00A 5c0oH-4ej6A:
8.2		 5c0oH-4ej6A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Burkholderia
vietnamiensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 273
GLY A 288
GLU A 324
HIS A 313
 None
None
None
N32  A 501 (-4.0A)
 1.21A 5c0oH-4f32A:
undetectable		 5c0oH-4f32A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9d POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Escherichia
coli) 		PF01522
(Polysacc_deac_1)
PF14883
(GHL13) 		4 THR A 535
GLY A 461
GLU A 275
ASP A 565
 None
 1.23A 5c0oH-4f9dA:
undetectable		 5c0oH-4f9dA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gve NUCLEOPROTEIN

(Tacaribe
mammarenavirus) 		PF17290
(Arena_ncap_C) 		4 GLY A 460
GLU A 388
HIS A 530
ASP A 463
 None
MG  A 602 (-2.5A)
None
None
 1.24A 5c0oH-4gveA:
undetectable		 5c0oH-4gveA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD

(Legionella
pneumophila) 		no annotation 4 THR A 252
GLY A 194
GLU A 212
ASP A 110
 None
None
None
MG  A 401 ( 2.8A)
 1.25A 5c0oH-4iikA:
undetectable		 5c0oH-4iikA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 THR A 210
GLU A 335
HIS A 310
ASP A 168
 None
 1.21A 5c0oH-4j3zA:
2.1		 5c0oH-4j3zA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Rickettsia
rickettsii) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 278
GLY A 293
GLU A 329
HIS A 318
 None
 1.21A 5c0oH-4jgaA:
undetectable		 5c0oH-4jgaA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycobacterium
tuberculosis) 		PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1) 		4 THR A 215
GLY A 217
HIS A 194
ASP A 211
 None
 1.24A 5c0oH-4kbmA:
undetectable		 5c0oH-4kbmA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 262
GLY A 277
GLU A 313
HIS A 302
 None
 1.17A 5c0oH-4ls5A:
undetectable		 5c0oH-4ls5A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvu OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Burkholderia
thailandensis) 		PF13561
(adh_short_C2) 		4 THR A  39
GLY A  37
GLU A  47
HIS A  48
 None
 1.18A 5c0oH-4lvuA:
7.2		 5c0oH-4lvuA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m01 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		no annotation 4 THR A 479
GLY A 329
HIS A 325
ASP A 290
 None
 1.17A 5c0oH-4m01A:
undetectable		 5c0oH-4m01A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlg BETA-XYLOSIDASE

(uncultured
organism) 		PF04616
(Glyco_hydro_43) 		4 THR A 298
GLY A 270
GLU A 223
HIS A 274
 None
None
SO4  A 402 (-3.3A)
CA  A 401 ( 3.9A)
 1.18A 5c0oH-4mlgA:
undetectable		 5c0oH-4mlgA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4of0 PROTEIN SYG-1,
ISOFORM B

(Caenorhabditis
elegans) 		PF07679
(I-set)
PF08205
(C2-set_2) 		4 THR A  95
GLY A  37
GLU A  90
ASP A  98
 None
 1.25A 5c0oH-4of0A:
undetectable		 5c0oH-4of0A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7a HISTONE-BINDING
PROTEIN RBBP4

(Homo sapiens) 		PF00400
(WD40)
PF12265
(CAF1C_H4-bd) 		4 THR B 297
GLY B 292
GLU B 275
ASP B 295
 None
 1.18A 5c0oH-4r7aB:
undetectable		 5c0oH-4r7aB:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1b LMO1466 PROTEIN

(Listeria
monocytogenes) 		PF01966
(HD) 		4 THR A 581
GLY A 546
GLU A 556
HIS A 514
 None
None
2BA  A 803 (-2.9A)
FE  A 802 ( 3.4A)
 1.17A 5c0oH-4s1bA:
undetectable		 5c0oH-4s1bA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A  56
GLY A  58
HIS A  51
ASP A 114
 None
 1.16A 5c0oH-4uekA:
6.9		 5c0oH-4uekA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 GLY A 651
GLU A 233
HIS A 150
ASP A 727
 None
 1.18A 5c0oH-4wjlA:
undetectable		 5c0oH-4wjlA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio cholerae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 261
GLY A 274
GLU A 306
HIS A 295
 None
 1.06A 5c0oH-4xoxA:
undetectable		 5c0oH-4xoxA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1b ANTE

(Streptomyces
sp. NRRL 2288) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 328
GLU A 300
HIS A 301
ASP A 305
 None
None
NAP  A 501 (-3.2A)
NAP  A 501 (-3.2A)
 1.06A 5c0oH-4y1bA:
6.6		 5c0oH-4y1bA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn8 RESPONSE REGULATOR
CHRA

(Corynebacterium
diphtheriae) 		PF00072
(Response_reg)
PF00196
(GerE) 		4 THR A  56
GLY A  58
HIS A  10
ASP A  35
 None
None
MG  A 204 (-3.5A)
None
 1.24A 5c0oH-4yn8A:
undetectable		 5c0oH-4yn8A:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 THR A 864
GLY A 787
HIS A 929
ASP A 870
 None
 1.26A 5c0oH-4zdnA:
undetectable		 5c0oH-4zdnA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zel DOPAMINE
BETA-HYDROXYLASE

(Homo sapiens) 		PF01082
(Cu2_monooxygen)
PF03351
(DOMON)
PF03712
(Cu2_monoox_C) 		4 THR A 254
GLY A 256
HIS A 262
ASP A 345
 None
 1.17A 5c0oH-4zelA:
undetectable		 5c0oH-4zelA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT
PUTATIVE
OXIDOREDUCTASE
IRON-SULFUR SUBUNIT

(Sulfurisphaera
tokodaii;
Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
PF00111
(Fer2)
PF01799
(Fer2_2) 		4 THR C  41
GLY C  39
HIS C  33
ASP A  25
 None
 1.12A 5c0oH-4zohC:
undetectable		 5c0oH-4zohC:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brq GLYCOSIDE HYDROLASE
FAMILY 13

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 THR A 432
GLY A 430
GLU A  38
ASP A  24
 None
None
None
MG  A 601 (-3.1A)
 0.98A 5c0oH-5brqA:
undetectable		 5c0oH-5brqA:
19.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI

(Thermus
thermophilus) 		PF08704
(GCD14) 		4 THR A  77
GLY A 106
GLU A 125
HIS A 130
 None
 0.58A 5c0oH-5c1iA:
31.7		 5c0oH-5c1iA:
98.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
BETA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		PF02239
(Cytochrom_D1) 		4 THR B 313
GLY B 305
HIS B 310
ASP B 287
 None
 1.19A 5c0oH-5c2vB:
undetectable		 5c0oH-5c2vB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cpc SECRETED EFFECTOR
PROTEIN SOPD

(Salmonella
enterica) 		PF11047
(SopD) 		4 GLY A  35
GLU A 163
HIS A 161
ASP A  38
 None
 1.25A 5c0oH-5cpcA:
undetectable		 5c0oH-5cpcA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do8 LMO0184 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 THR B 431
GLY B 429
GLU B  36
ASP B  22
 None
 0.98A 5c0oH-5do8B:
undetectable		 5c0oH-5do8B:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE

(Bacillus
subtilis) 		PF00698
(Acyl_transf_1) 		4 THR A 120
GLY A 190
GLU A  55
HIS A  53
 None
 1.14A 5c0oH-5dz7A:
undetectable		 5c0oH-5dz7A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erb POLYKETIDE SYNTHASE

(Bacillus
amyloliquefaciens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 THR A 320
GLY A 243
HIS A 385
ASP A 326
 None
 1.18A 5c0oH-5erbA:
undetectable		 5c0oH-5erbA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz TUBULIN GAMMA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 THR C 273
GLY C 374
GLU C 327
HIS C 289
 None
 1.14A 5c0oH-5flzC:
undetectable		 5c0oH-5flzC:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hph HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL

(Homo sapiens) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		4 THR A 249
GLY A 160
GLU A 142
HIS A 144
 None
 1.07A 5c0oH-5hphA:
undetectable		 5c0oH-5hphA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ify GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		4 THR A  56
GLY A  11
HIS A  21
ASP A  59
 None
TRH  A 500 (-4.9A)
None
None
 1.25A 5c0oH-5ifyA:
undetectable		 5c0oH-5ifyA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktk POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		4 THR A 122
GLY A 137
GLU A 398
ASP A 160
 None
 1.16A 5c0oH-5ktkA:
5.7		 5c0oH-5ktkA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME

(Pseudomonas
savastanoi) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 THR A 190
GLU A 285
HIS A 169
ASP A 253
 None
 1.17A 5c0oH-5lunA:
undetectable		 5c0oH-5lunA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu7 COATOMER SUBUNIT
BETA
COATOMER SUBUNIT
DELTA-LIKE PROTEIN

(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		PF01602
(Adaptin_N)
PF01217
(Clat_adaptor_s) 		4 THR A 119
GLY A 117
GLU B 141
ASP A 107
 None
 1.19A 5c0oH-5mu7A:
undetectable		 5c0oH-5mu7A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzh DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1

(Chlamydomonas
reinhardtii) 		PF00400
(WD40) 		4 THR A 202
GLY A 197
GLU A 181
ASP A 200
 None
 1.26A 5c0oH-5mzhA:
undetectable		 5c0oH-5mzhA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o99 SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3

(Rattus
norvegicus) 		no annotation 4 THR B 516
GLY B 514
GLU B 495
HIS B 492
 None
 1.16A 5c0oH-5o99B:
undetectable		 5c0oH-5o99B:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT
ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile;
Clostridioides
difficile) 		no annotation
no annotation 		4 THR C  65
GLY C  67
GLU B 201
ASP C 306
 None
 1.18A 5c0oH-5ol2C:
undetectable		 5c0oH-5ol2C:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B

(Methanothermobacter
sp. CaT2) 		PF00384
(Molybdopterin) 		4 THR B  92
GLU B 366
HIS B 368
ASP B 414
 MGD  B 503 ( 4.9A)
MGD  B 503 (-2.9A)
MGD  B 503 (-4.4A)
MGD  B 503 (-3.0A)
 1.27A 5c0oH-5t5iB:
2.1		 5c0oH-5t5iB:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpu 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Acinetobacter
baumannii) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 GLY A 120
GLU A 131
HIS A 130
ASP A 155
 None
None
EDO  A 607 (-3.8A)
None
 1.22A 5c0oH-5vpuA:
4.5		 5c0oH-5vpuA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE

(Eimeria tenella) 		no annotation 4 THR A 460
GLY A 457
GLU A 361
HIS A 411
 None
None
HFG  A1003 (-2.9A)
HFG  A1003 ( 4.7A)
 1.25A 5c0oH-5xipA:
undetectable		 5c0oH-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6am0 KLLA0F23980P
KLLA0A01474P

(Kluyveromyces
lactis;
Kluyveromyces
lactis) 		no annotation
no annotation 		4 THR C 366
GLY A 136
GLU A  46
HIS A  43
 None
 1.22A 5c0oH-6am0C:
undetectable		 5c0oH-6am0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byx SHORT ULVAN LYASE

(Alteromonas sp.
LOR) 		no annotation 4 THR A 134
GLY A 138
HIS A 146
ASP A 165
 None
 1.26A 5c0oH-6byxA:
undetectable		 5c0oH-6byxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fax TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER 5

(Homo sapiens) 		no annotation 4 GLY R  44
GLU R  74
HIS R  76
ASP R  69
 None
 1.25A 5c0oH-6faxR:
undetectable		 5c0oH-6faxR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fay ODZ3 PROTEIN

(Mus musculus) 		no annotation 4 THR A1449
GLY A1430
GLU A1104
ASP A1451
 None
 1.20A 5c0oH-6fayA:
undetectable		 5c0oH-6fayA:
undetectable