SIMILAR PATTERNS OF AMINO ACIDS FOR 5C0O_H_SAMH301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		5 ALA A 119
GLY A 111
GLY A 116
GLY A 114
LEU A 110
 None
None
GLC  A 997 (-4.8A)
PLP  A 999 ( 3.6A)
None
 0.93A 5c0oH-1e4oA:
2.5		 5c0oH-1e4oA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE

(Rattus
norvegicus) 		PF00106
(adh_short) 		5 ALA A  27
GLY A  17
GLY A  23
GLY A  21
LEU A  40
 None
NAD  A 301 (-3.5A)
None
NAD  A 301 (-3.2A)
None
 0.83A 5c0oH-1e6wA:
6.5		 5c0oH-1e6wA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1geu GLUTATHIONE
REDUCTASE

(Escherichia
coli) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A  11
GLY A  13
SER A  14
GLY A  15
LYS A 112
 FAD  A 451 (-3.4A)
FAD  A 451 (-3.0A)
FAD  A 451 (-3.1A)
FAD  A 451 (-3.5A)
None
 0.92A 5c0oH-1geuA:
3.2		 5c0oH-1geuA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq1 CYTOCHROME CD1
NITRITE REDUCTASE

(Paracoccus
pantotrophus) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		5 PRO A 387
GLY A 441
GLY A 410
ARG A  20
LEU A 460
 None
 1.07A 5c0oH-1gq1A:
undetectable		 5c0oH-1gq1A:
18.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		7 GLY A 107
GLY A 109
SER A 110
GLY A 111
LEU A 113
ARG A 133
LEU A 162
 SAM  A 301 (-2.7A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.4A)
SAM  A 301 (-4.2A)
SAM  A 301 (-4.5A)
None
None
 0.91A 5c0oH-1i9gA:
28.3		 5c0oH-1i9gA:
38.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Escherichia
coli) 		PF03740
(PdxJ) 		5 ALA A 191
GLY A 192
GLY A 194
LYS A 235
LEU A 237
 None
None
PO4  A1002 (-3.5A)
None
None
 1.05A 5c0oH-1ixpA:
undetectable		 5c0oH-1ixpA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1or8 PROTEIN ARGININE
N-METHYLTRANSFERASE
1

(Rattus
norvegicus) 		PF13649
(Methyltransf_25) 		5 GLY A  78
GLY A  80
GLY A  82
LEU A  84
LYS A 127
 SAH  A 354 (-2.9A)
SAH  A 354 (-3.6A)
None
SAH  A 354 (-4.2A)
None
 1.07A 5c0oH-1or8A:
10.4		 5c0oH-1or8A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 ALA A 510
GLY A 501
GLY A 506
GLY A 504
LEU A 560
 None
NAP  A 703 ( 3.9A)
None
NAP  A 703 (-3.5A)
None
 1.06A 5c0oH-1ps9A:
5.1		 5c0oH-1ps9A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6b CLPA PROTEIN

(Escherichia
coli) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 ALA X 749
GLY X 728
GLY X 677
LEU X 673
LEU X 721
 None
 1.06A 5c0oH-1r6bX:
undetectable		 5c0oH-1r6bX:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II

(Homo sapiens) 		PF00106
(adh_short) 		5 ALA A  27
GLY A  17
GLY A  23
GLY A  21
LEU A  40
 None
NA  A 302 (-3.6A)
NA  A 302 ( 4.5A)
NA  A 302 ( 4.3A)
None
 0.83A 5c0oH-1so8A:
6.9		 5c0oH-1so8A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to6 GLYCERATE KINASE

(Neisseria
meningitidis) 		PF02595
(Gly_kinase) 		5 ALA A 202
GLY A 249
GLY A 242
GLY A 240
LEU A 238
 None
 1.01A 5c0oH-1to6A:
undetectable		 5c0oH-1to6A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Thermus
thermophilus) 		PF01070
(FMN_dh) 		5 ALA A 246
PRO A 242
GLY A 190
GLY A 192
GLY A 240
 None
None
FMN  A 501 (-3.8A)
None
None
 0.94A 5c0oH-1vcgA:
undetectable		 5c0oH-1vcgA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		5 ALA A 140
GLY A 132
GLY A 137
GLY A 135
LEU A 131
 None
None
None
PLP  A 860 ( 3.3A)
None
 0.87A 5c0oH-1ygpA:
undetectable		 5c0oH-1ygpA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsw GLYOXALASE FAMILY
PROTEIN

(Bacillus cereus) 		PF00903
(Glyoxalase) 		5 ALA A 199
GLY A 156
GLY A 158
SER A 159
GLY A  82
 None
 0.90A 5c0oH-1zswA:
undetectable		 5c0oH-1zswA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9h VOLTAGE-GATED
POTASSIUM CHANNEL

(Streptomyces
lividans) 		PF07885
(Ion_trans_2) 		5 ALA A  65
GLY A  88
SER A  44
GLY A  43
LEU A  86
 None
 1.06A 5c0oH-2a9hA:
undetectable		 5c0oH-2a9hA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9l PROPHENOLOXIDASE
ACTIVATING FACTOR

(Holotrichia
diomphalia) 		PF00089
(Trypsin) 		5 GLY A 198
GLY A 354
SER A 355
GLY A 187
LEU A 196
 None
 0.85A 5c0oH-2b9lA:
undetectable		 5c0oH-2b9lA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1

(Mesorhizobium
loti) 		PF00797
(Acetyltransf_2) 		5 ALA A 211
PRO A  41
GLY A 129
GLY A  71
LEU A 114
 None
 1.06A 5c0oH-2bszA:
undetectable		 5c0oH-2bszA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		5 ALA A 119
GLY A 111
GLY A 116
GLY A 114
LEU A 110
 None
None
None
PO4  A1794 (-3.4A)
None
 0.90A 5c0oH-2c4mA:
3.1		 5c0oH-2c4mA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		5 ALA A 140
GLY A 132
GLY A 137
GLY A 135
LEU A 131
 None
None
None
PLR  A 940 ( 3.8A)
None
 0.80A 5c0oH-2gj4A:
undetectable		 5c0oH-2gj4A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hna PROTEIN MIOC

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		5 GLY A  38
GLY A   9
SER A  10
LEU A  40
LEU A  36
 None
 1.09A 5c0oH-2hnaA:
undetectable		 5c0oH-2hnaA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iss PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS

(Thermotoga
maritima) 		PF01680
(SOR_SNZ) 		5 ALA A 217
GLY A 154
GLY A 156
GLY A 278
GLU A 106
 None
5RP  A 294 (-3.4A)
None
None
None
 0.97A 5c0oH-2issA:
undetectable		 5c0oH-2issA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq2 HYPOTHETICAL ABC
TRANSPORTER PERMEASE
PROTEIN HI1471

(Haemophilus
influenzae) 		PF01032
(FecCD) 		5 GLY A 128
GLY A 102
GLY A 106
LEU A 126
LEU A 132
 None
 1.06A 5c0oH-2nq2A:
undetectable		 5c0oH-2nq2A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwh CARBOHYDRATE KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		5 ALA A  43
GLY A   8
GLY A  40
GLY A  38
LEU A   7
 None
None
None
CL  A 403 (-3.5A)
None
 0.96A 5c0oH-2nwhA:
5.2		 5c0oH-2nwhA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwh CARBOHYDRATE KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		5 ALA A  44
GLY A   8
GLY A  40
GLY A  38
LEU A   7
 None
None
None
CL  A 403 (-3.5A)
None
 1.05A 5c0oH-2nwhA:
5.2		 5c0oH-2nwhA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paa PHOSPHOGLYCERATE
KINASE, TESTIS
SPECIFIC

(Mus musculus) 		PF00162
(PGK) 		5 ALA A 214
GLY A 337
GLY A 213
GLY A 236
LEU A 211
 ATP  A 500 (-3.4A)
ATP  A 500 (-3.1A)
ATP  A 500 (-2.8A)
None
None
 1.01A 5c0oH-2paaA:
4.2		 5c0oH-2paaA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2l SUPEROXIDE DISMUTASE

(Potentilla
atrosanguinea) 		PF00080
(Sod_Cu) 		5 GLY A  40
GLY A  89
GLY A  92
LEU A  37
LEU A  41
 None
 0.97A 5c0oH-2q2lA:
undetectable		 5c0oH-2q2lA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qde MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Aromatoleum
aromaticum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 346
GLY A 303
SER A 302
GLY A 301
GLU A 353
 None
 1.06A 5c0oH-2qdeA:
1.4		 5c0oH-2qdeA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		5 ALA A 335
GLY A 187
SER A 164
LEU A  83
GLU A  84
 None
 1.08A 5c0oH-2vz9A:
undetectable		 5c0oH-2vz9A:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkn FORMAMIDASE

(Delftia
acidovorans) 		PF03069
(FmdA_AmdA) 		5 ALA A  81
PRO A  83
GLY A 245
GLY A 243
LEU A 246
 None
 1.02A 5c0oH-2wknA:
undetectable		 5c0oH-2wknA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ALA A  23
GLY A  14
GLY A  19
GLY A  17
LEU A  36
 None
FAD  A 601 (-3.1A)
None
FAD  A 601 (-4.2A)
None
 1.06A 5c0oH-2wu5A:
3.3		 5c0oH-2wu5A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum) 		PF00245
(Alk_phosphatase) 		5 ALA A 309
GLY A 307
GLY A 350
LEU A 352
GLU A 320
 None
 0.79A 5c0oH-2x98A:
undetectable		 5c0oH-2x98A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro)
PF08369
(PCP_red) 		5 ALA D 133
GLY D 178
GLY D 173
LEU D 205
LEU D 177
 None
None
None
None
GOL  D1530 ( 4.6A)
 1.01A 5c0oH-2ynmD:
undetectable		 5c0oH-2ynmD:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 5 ALA A 117
GLY A  67
GLY A  65
GLY A  63
GLU A 662
 None
FAD  A 801 (-3.4A)
FAD  A 801 (-3.6A)
FAD  A 801 (-3.1A)
None
 0.97A 5c0oH-2yr5A:
3.6		 5c0oH-2yr5A:
18.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yvl HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF08704
(GCD14) 		5 GLY A  99
GLY A 101
SER A 102
GLY A 103
LEU A 105
 SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-4.6A)
SAM  A 601 (-4.0A)
SAM  A 601 (-4.6A)
 0.59A 5c0oH-2yvlA:
26.5		 5c0oH-2yvlA:
33.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw9 ENOYL-[ACYL CARRIER
PROTEIN] REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		5 GLY A 141
GLY A 139
GLY A 182
LEU A  90
LEU A 234
 None
 0.97A 5c0oH-2yw9A:
6.8		 5c0oH-2yw9A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN

(Thermus
thermophilus) 		PF00753
(Lactamase_B) 		5 ALA A 191
GLY A 189
GLY A 232
LEU A 180
GLU A 181
 None
 1.07A 5c0oH-2zo4A:
undetectable		 5c0oH-2zo4A:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		5 ALA A 140
GLY A 132
GLY A 137
GLY A 135
LEU A 131
 None
None
None
PLP  A 832 (-3.9A)
None
 0.81A 5c0oH-3cemA:
2.3		 5c0oH-3cemA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxg RHAMNONATE
DEHYDRATASE

(Fusarium
graminearum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A  88
PRO A  86
GLY A  82
GLY A  84
GLY A  64
 None
 0.92A 5c0oH-3fxgA:
undetectable		 5c0oH-3fxgA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdc MULTICOPPER OXIDASE

(Arthrobacter
sp. FB24) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ALA A 281
GLY A 290
GLY A 293
GLU A 192
LEU A 289
 None
None
None
CA  A 401 (-2.2A)
None
 0.97A 5c0oH-3gdcA:
undetectable		 5c0oH-3gdcA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ALA A 335
GLY A 187
SER A 164
LEU A  83
GLU A  84
 None
 1.07A 5c0oH-3hhdA:
3.0		 5c0oH-3hhdA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1j OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF00106
(adh_short) 		5 ALA A  30
GLY A  20
GLY A  26
GLY A  24
LEU A  43
 None
EDO  A 252 (-3.3A)
None
CL  A 255 ( 3.8A)
EDO  A 252 (-4.5A)
 0.82A 5c0oH-3i1jA:
6.9		 5c0oH-3i1jA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwj PUTATIVE
AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		5 PRO A 207
GLY A  14
GLY A 209
LEU A 211
LEU A 195
 None
 1.06A 5c0oH-3iwjA:
4.0		 5c0oH-3iwjA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE

(Methanocaldococcus
jannaschii) 		PF02277
(DBI_PRT) 		5 ALA A 323
GLY A 265
GLY A 320
GLY A 318
LEU A 291
 None
 1.05A 5c0oH-3l0zA:
undetectable		 5c0oH-3l0zA:
22.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lga SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
abyssi) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		5 GLY A 101
GLY A 103
GLY A 105
LEU A 107
ARG A 127
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.3A)
None
 1.06A 5c0oH-3lgaA:
25.3		 5c0oH-3lgaA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lga SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
abyssi) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		5 GLY A 101
GLY A 103
SER A 104
GLY A 105
LEU A 107
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.3A)
 0.46A 5c0oH-3lgaA:
25.3		 5c0oH-3lgaA:
35.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n70 TRANSPORT ACTIVATOR

(Escherichia
coli) 		PF14532
(Sigma54_activ_2) 		5 ALA A 174
GLY A 173
GLY A 255
LEU A 171
LEU A 284
 None
 0.97A 5c0oH-3n70A:
undetectable		 5c0oH-3n70A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o14 ANTI-ECFSIGMA
FACTOR, CHRR

(Marinobacter
hydrocarbonoclasticus) 		PF12973
(Cupin_7) 		5 GLY A 164
ARG A 144
LYS A 210
GLU A 167
LEU A 214
 None
 0.71A 5c0oH-3o14A:
undetectable		 5c0oH-3o14A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocd SOXA

(Starkeya
novella) 		no annotation 5 GLY A  85
GLY A  77
LYS A 151
LEU A 268
GLU A 267
 None
 0.99A 5c0oH-3ocdA:
undetectable		 5c0oH-3ocdA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s0m OXALATE
DECARBOXYLASE OXDC

(Bacillus
subtilis) 		PF00190
(Cupin_1) 		5 GLY A 129
GLY A 127
SER A 109
GLY A 108
LEU A 261
 None
 1.06A 5c0oH-3s0mA:
undetectable		 5c0oH-3s0mA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v6b VEGF-E

(Orf virus) 		PF00341
(PDGF) 		5 GLY A  85
SER A  86
GLY A  87
ARG A  46
GLU A  41
 None
 0.96A 5c0oH-3v6bA:
undetectable		 5c0oH-3v6bA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8b PUTATIVE
DEHYDROGENASE,
POSSIBLY
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 ALA A  22
GLY A  12
GLY A  18
GLY A  16
LEU A  35
 None
 0.77A 5c0oH-3v8bA:
6.6		 5c0oH-3v8bA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE

(Thermotoga
maritima) 		PF00933
(Glyco_hydro_3) 		5 GLY A 240
GLY A 237
LEU A 198
ARG A 304
LEU A 241
 None
 1.04A 5c0oH-3wo8A:
undetectable		 5c0oH-3wo8A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs6 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Burkholderia
pseudomallei) 		PF00496
(SBP_bac_5) 		5 ALA A 119
GLY A  85
GLY A 226
LEU A 201
LEU A  86
 None
 1.04A 5c0oH-3zs6A:
undetectable		 5c0oH-3zs6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0m BETAINE ALDEHYDE
DEHYDROGENASE,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00171
(Aldedh) 		5 PRO A 204
GLY A  14
GLY A 206
LEU A 208
LEU A 192
 None
 1.06A 5c0oH-4a0mA:
3.9		 5c0oH-4a0mA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ads PYRIDOXINE
BIOSYNTHETIC ENZYME
PDX1 HOMOLOGUE,
PUTATIVE

(Plasmodium
berghei) 		PF01680
(SOR_SNZ) 		5 ALA A 219
GLY A 156
GLY A 158
GLY A 280
GLU A 108
 None
PO4  A 302 (-3.6A)
None
None
None
 0.93A 5c0oH-4adsA:
undetectable		 5c0oH-4adsA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF13561
(adh_short_C2) 		5 ALA A  27
GLY A  17
GLY A  23
GLY A  21
LEU A  40
 None
 1.01A 5c0oH-4avyA:
6.4		 5c0oH-4avyA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b45 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		5 GLY A   7
GLY A   9
SER A 107
GLY A 108
LEU A   5
 None
GSP  A1342 (-3.5A)
GSP  A1342 (-4.1A)
GSP  A1342 (-4.0A)
None
 1.03A 5c0oH-4b45A:
3.8		 5c0oH-4b45A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgf ARYLAMINE
N-ACETYLTRANSFERASE
NAT

(Mycobacterium
tuberculosis) 		PF00797
(Acetyltransf_2) 		5 ALA A 211
PRO A  37
GLY A 129
GLY A  68
LEU A 112
 None
 1.02A 5c0oH-4bgfA:
undetectable		 5c0oH-4bgfA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana) 		PF00343
(Phosphorylase) 		5 ALA A 143
GLY A 135
GLY A 140
GLY A 138
LEU A 134
 None
None
None
PLP  A 901 (-3.3A)
None
 0.97A 5c0oH-4bqiA:
2.5		 5c0oH-4bqiA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica) 		PF00291
(PALP) 		5 ALA A 196
GLY A 201
GLY A 197
SER A 161
GLU A 207
 None
None
LLP  A  51 ( 4.2A)
LLP  A  51 ( 3.4A)
None
 1.06A 5c0oH-4d8uA:
undetectable		 5c0oH-4d8uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING

(Polaromonas sp.
JS666) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ALA A 236
GLY A 156
GLY A 205
ARG A 153
LEU A 211
 GOL  A 401 (-4.1A)
None
None
GOL  A 401 (-3.8A)
None
 1.08A 5c0oH-4g2nA:
6.6		 5c0oH-4g2nA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxy PLM1

(Streptomyces
sp. HK803) 		PF08659
(KR) 		5 ALA A 201
GLY A 191
GLY A 197
GLY A 195
LEU A 216
 None
NDP  A 501 (-3.5A)
None
NDP  A 501 (-3.4A)
None
 0.78A 5c0oH-4hxyA:
6.7		 5c0oH-4hxyA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		6 PRO A 207
GLY A  17
SER A 208
GLY A 209
LEU A 211
LEU A 195
 None
 1.18A 5c0oH-4i8qA:
3.9		 5c0oH-4i8qA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksi LEUCINE
AMINOPEPTIDASE 1,
CHLOROPLASTIC

(Solanum
lycopersicum) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 ALA A 253
GLY A 254
GLY A 258
LEU A 375
LEU A 381
 None
 0.93A 5c0oH-4ksiA:
undetectable		 5c0oH-4ksiA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l05 SUPEROXIDE DISMUTASE
[CU-ZN]

(Brucella
abortus) 		PF00080
(Sod_Cu) 		5 GLY A  46
GLY A 130
GLY A 145
LEU A  94
LEU A  97
 None
 1.06A 5c0oH-4l05A:
undetectable		 5c0oH-4l05A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l22 PHOSPHORYLASE

(Streptococcus
mutans) 		PF00343
(Phosphorylase) 		5 ALA A 110
GLY A 102
GLY A 107
GLY A 105
LEU A 101
 None
 0.92A 5c0oH-4l22A:
2.9		 5c0oH-4l22A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsy LYSYL ENDOPEPTIDASE

(Lysobacter
enzymogenes) 		PF13365
(Trypsin_2) 		6 ALA A 146
GLY A 207
SER A 196
GLY A 195
LEU A  53
LEU A 206
 None
 1.44A 5c0oH-4nsyA:
undetectable		 5c0oH-4nsyA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nu3 ICE-BINDING PROTEIN

(Flavobacterium
frigoris) 		PF11999
(DUF3494) 		5 GLY A 168
SER A 169
GLY A 195
LEU A 192
LEU A 147
 None
 0.94A 5c0oH-4nu3A:
undetectable		 5c0oH-4nu3A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odm PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD

(Thermus
thermophilus) 		PF00254
(FKBP_C) 		5 GLY A  64
GLY A 123
LEU A 121
LEU A  40
GLU A  41
 None
 0.82A 5c0oH-4odmA:
undetectable		 5c0oH-4odmA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo sapiens) 		PF13489
(Methyltransf_23) 		5 GLY A 195
GLY A 197
SER A 198
GLY A 199
GLU A 269
 SAM  A 401 (-3.0A)
SAM  A 401 (-4.2A)
None
None
SAM  A 401 (-4.0A)
 0.97A 5c0oH-4rfqA:
13.7		 5c0oH-4rfqA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo sapiens) 		PF13489
(Methyltransf_23) 		5 GLY A 195
GLY A 197
SER A 198
GLY A 199
LEU A 201
 SAM  A 401 (-3.0A)
SAM  A 401 (-4.2A)
None
None
None
 0.73A 5c0oH-4rfqA:
13.7		 5c0oH-4rfqA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvp SUPEROXIDE DISMUTASE

(Sedum alfredii) 		PF00080
(Sod_Cu) 		5 GLY A  84
GLY A 139
SER A 146
GLY A 150
GLU A  89
 None
 1.05A 5c0oH-4rvpA:
undetectable		 5c0oH-4rvpA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 ALA A 246
GLY A 277
GLY A 251
GLY A 269
ARG A 245
 None
 0.77A 5c0oH-4um8A:
undetectable		 5c0oH-4um8A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE

(Agrobacterium
tumefaciens) 		PF00701
(DHDPS) 		5 ALA A 195
PRO A 193
GLY A 191
GLY A 168
LEU A  15
 None
OOG  A1305 ( 4.7A)
OOG  A1305 (-4.5A)
None
None
 1.05A 5c0oH-4ur8A:
undetectable		 5c0oH-4ur8A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y2w ALANINE RACEMASE 1

(Caldanaerobacter
subterraneus) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 ALA A 147
GLY A 140
LYS A 113
LEU A 115
GLU A 116
 None
 0.94A 5c0oH-4y2wA:
2.0		 5c0oH-4y2wA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 GLY A1670
GLY A1672
SER A1673
GLY A1674
LEU A1736
 None
 0.85A 5c0oH-5a22A:
10.2		 5c0oH-5a22A:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b58 PUTATIVE HEMIN ABC
TRANSPORT SYSTEM,
MEMBRANE PROTEIN

(Burkholderia
cenocepacia) 		PF01032
(FecCD) 		5 ALA A 311
GLY A 289
GLY A  96
GLY A  92
LEU A 290
 None
 0.93A 5c0oH-5b58A:
undetectable		 5c0oH-5b58A:
22.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI

(Thermus
thermophilus) 		PF08704
(GCD14) 		6 GLY A 101
GLY A 103
GLY A 105
LEU A 107
ARG A 127
LEU A 154
 None
 0.68A 5c0oH-5c1iA:
30.4		 5c0oH-5c1iA:
98.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI

(Thermus
thermophilus) 		PF08704
(GCD14) 		6 GLY A 101
GLY A 103
SER A 104
GLY A 105
LEU A 107
LEU A 154
 None
 0.83A 5c0oH-5c1iA:
30.4		 5c0oH-5c1iA:
98.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI

(Thermus
thermophilus) 		PF08704
(GCD14) 		6 GLY A 101
SER A 104
GLY A 105
LEU A 107
LEU A 154
LEU A 171
 None
 0.82A 5c0oH-5c1iA:
30.4		 5c0oH-5c1iA:
98.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI

(Thermus
thermophilus) 		PF08704
(GCD14) 		6 GLY A 101
SER A 104
GLY A 105
LEU A 154
GLU A 155
LEU A 171
 None
 0.94A 5c0oH-5c1iA:
30.4		 5c0oH-5c1iA:
98.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae) 		PF08704
(GCD14) 		5 GLY B 118
GLY B 120
SER B 121
GLY B 122
LEU B 204
 SAM  B 401 (-3.4A)
SAM  B 401 (-3.3A)
SAM  B 401 (-3.1A)
SAM  B 401 (-3.9A)
SAM  B 401 (-4.5A)
 0.70A 5c0oH-5ergB:
19.6		 5c0oH-5ergB:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1

(Mus musculus) 		PF01344
(Kelch_1) 		5 ALA A 522
GLY A 558
GLY A 511
GLY A 509
LEU A 569
 None
None
None
L6I  A1615 (-3.0A)
None
 0.91A 5c0oH-5fnuA:
undetectable		 5c0oH-5fnuA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ifz RIBOSE 5-PHOSPHATE
ISOMERASE

(Brucella
melitensis) 		PF02502
(LacAB_rpiB) 		5 GLY A  20
GLY A  24
GLY A  26
LYS A  57
LEU A  76
 None
 0.99A 5c0oH-5ifzA:
undetectable		 5c0oH-5ifzA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		5 ALA A 140
GLY A 132
GLY A 137
GLY A 135
LEU A 131
 None
None
None
PLP  A 901 ( 3.8A)
None
 1.06A 5c0oH-5ikpA:
2.4		 5c0oH-5ikpA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021

(Burkholderia
pseudomallei) 		PF00282
(Pyridoxal_deC) 		5 ALA A 267
GLY A 273
SER A 280
GLY A 279
LEU A 329
 None
 0.84A 5c0oH-5k1rA:
undetectable		 5c0oH-5k1rA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k2z PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.3

(Arabidopsis
thaliana) 		PF01680
(SOR_SNZ) 		5 ALA A 232
GLY A 169
GLY A 171
GLY A 293
GLU A 121
 None
SO4  A 403 (-3.6A)
None
None
EDO  A 405 ( 3.8A)
 0.93A 5c0oH-5k2zA:
undetectable		 5c0oH-5k2zA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Legionella
pneumophila) 		PF00290
(Trp_syntA) 		5 ALA A  71
GLY A  26
LEU A  32
LEU A  48
GLU A  49
 None
 1.04A 5c0oH-5k9xA:
undetectable		 5c0oH-5k9xA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		5 ALA A 187
GLY A 179
GLY A 184
GLY A 182
LEU A 178
 None
None
None
GLC  A1001 ( 3.7A)
None
 0.91A 5c0oH-5lrbA:
2.2		 5c0oH-5lrbA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtf RHOMBOID PROTEASE
GLPG

(Escherichia
coli) 		no annotation 5 ALA A 263
GLY A 209
GLY A 261
GLY A 257
LEU A 225
 None
BNG  A 304 ( 4.2A)
None
None
None
 1.05A 5c0oH-5mtfA:
undetectable		 5c0oH-5mtfA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 5 ALA B 335
GLY B 187
SER B 164
LEU B  83
GLU B  84
 None
 1.06A 5c0oH-5my0B:
undetectable		 5c0oH-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd4 TUBULIN ALPHA CHAIN

(Bos taurus) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 ALA A 126
GLY A 134
GLY A 131
LEU A 167
GLU A 168
 None
 1.01A 5c0oH-5nd4A:
3.9		 5c0oH-5nd4A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7x NOD FACTOR BINDING
LECTIN-NUCLEOTIDE
PHOSPHOHYDROLASE

(Vigna
unguiculata) 		PF01150
(GDA1_CD39) 		5 GLY F 287
GLY F 289
SER F 290
GLY F 291
GLU F 276
 None
 1.04A 5c0oH-5u7xF:
undetectable		 5c0oH-5u7xF:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7z ACID CERAMIDASE
ACID CERAMIDASE

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		5 GLY A 106
GLY A 103
LEU A 101
LEU B 237
GLU B 238
 None
 1.01A 5c0oH-5u7zA:
undetectable		 5c0oH-5u7zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4j UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		no annotation 5 ALA A 158
GLY A 138
SER A 137
GLY A 136
LEU A 104
 None
None
None
ZN  A 501 ( 4.8A)
None
 0.96A 5c0oH-5x4jA:
2.8		 5c0oH-5x4jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xdm SEPTUM
SITE-DETERMINING
PROTEIN MINC

(Escherichia
coli) 		no annotation 5 ALA A  48
GLY A  49
SER A  29
GLY A  30
LEU A  89
 None
 1.07A 5c0oH-5xdmA:
undetectable		 5c0oH-5xdmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoi OXIDOREDUCTASE,
2OG-FE OXYGENASE
FAMILY PROTEIN,
PUTATIVE, EXPRESSED

(Oryza sativa) 		no annotation 5 ALA A 220
PRO A 222
GLY A 178
GLY A 180
LEU A 175
 None
 0.79A 5c0oH-5xoiA:
undetectable		 5c0oH-5xoiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y09 PROTEASE DO-LIKE 9

(Arabidopsis
thaliana) 		no annotation 5 ALA A 293
PRO A 281
GLY A 279
GLY A 156
LEU A 165
 None
 1.07A 5c0oH-5y09A:
undetectable		 5c0oH-5y09A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb8 PFUENDOQ

(Pyrococcus
furiosus) 		no annotation 6 GLY A 242
GLY A 373
GLY A 375
ARG A 280
LEU A 237
LEU A 241
 None
 1.29A 5c0oH-5zb8A:
undetectable		 5c0oH-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fmq -

(-) 		no annotation 5 ALA A 522
GLY A 558
GLY A 511
GLY A 509
LEU A 569
 None
None
None
NA  A 708 ( 3.7A)
None
 0.95A 5c0oH-6fmqA:
undetectable		 5c0oH-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9z EXCINUCLEASE UVRABC
COMPONENT UVRB

([Bacillus]
caldotenax) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		4 GLY A 217
GLU A 239
HIS A 240
ASP A 228
 None
 1.18A 5c0oH-1d9zA:
4.7		 5c0oH-1d9zA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II

(Synechocystis
sp. PCC 6803) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 267
GLY A 282
GLU A 318
HIS A 307
 None
 1.22A 5c0oH-1e5mA:
undetectable		 5c0oH-1e5mA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		4 THR C 295
GLU C 353
HIS C 350
ASP C 293
 None
 1.20A 5c0oH-1h2tC:
undetectable		 5c0oH-1h2tC:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE

(Pyrococcus
horikoshii) 		PF00857
(Isochorismatase) 		4 THR A  50
GLY A 105
GLU A 101
ASP A  10
 None
None
ZN  A 400 ( 4.1A)
None
 1.15A 5c0oH-1im5A:
4.1		 5c0oH-1im5A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwm PROCARBOXYPEPTIDASE
B

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		4 THR A 164
GLU A  72
HIS A 196
ASP A  41
 None
ZN  A 400 (-2.1A)
ZN  A 400 (-3.3A)
None
 1.16A 5c0oH-1kwmA:
undetectable		 5c0oH-1kwmA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE

(Haemophilus
influenzae) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 THR A  56
GLY A  27
HIS A  74
ASP A  52
 None
EPU  A 598 (-3.7A)
None
None
 1.25A 5c0oH-1p31A:
4.8		 5c0oH-1p31A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1d APYRASE

(Homo sapiens) 		PF06079
(Apyrase) 		4 THR A 114
GLY A 141
GLU A 145
ASP A 111
 None
None
GP2  A4001 ( 2.7A)
None
 0.97A 5c0oH-1s1dA:
undetectable		 5c0oH-1s1dA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um4 ANTIBODY 21H3 H
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR H  88
GLY H  16
GLU H  83
ASP H  91
 None
 1.26A 5c0oH-1um4H:
undetectable		 5c0oH-1um4H:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		4 THR A  77
GLY A  79
GLU A 197
HIS A 200
 None
None
FE  A1292 ( 2.1A)
FE  A1293 (-3.2A)
 1.15A 5c0oH-1uzrA:
undetectable		 5c0oH-1uzrA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6f ARYLAMINE
N-ACETYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF00797
(Acetyltransf_2) 		4 THR A 234
GLY A 232
GLU A 152
HIS A 151
 None
 1.04A 5c0oH-1w6fA:
undetectable		 5c0oH-1w6fA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9z VP9

(Banna virus) 		PF08978
(Reoviridae_Vp9) 		4 THR A 115
GLY A 126
GLU A 149
HIS A 150
 None
 1.21A 5c0oH-1w9zA:
undetectable		 5c0oH-1w9zA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B) 		4 THR A 277
GLY A  42
HIS A 112
ASP A  44
 None
None
FE  A 401 ( 3.3A)
None
 1.22A 5c0oH-1wraA:
undetectable		 5c0oH-1wraA:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b25 HYPOTHETICAL PROTEIN

(Homo sapiens) 		PF08704
(GCD14) 		5 THR A  87
GLY A 116
GLU A 135
HIS A 140
ASP A 192
 SAM  A 601 (-3.7A)
SAM  A 601 (-3.5A)
SAM  A 601 (-2.9A)
SAM  A 601 (-4.0A)
SAM  A 601 (-3.5A)
 0.76A 5c0oH-2b25A:
25.7		 5c0oH-2b25A:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4v RNA EDITING COMPLEX
PROTEIN MP57

(Trypanosoma
brucei) 		PF01909
(NTP_transf_2)
PF03828
(PAP_assoc) 		4 THR A 364
GLY A 367
HIS A 294
ASP A 362
 None
 1.21A 5c0oH-2b4vA:
undetectable		 5c0oH-2b4vA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA

(Escherichia
coli) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 GLY A1311
GLU A1144
HIS A1147
ASP A1314
 None
 1.23A 5c0oH-2bruA:
6.0		 5c0oH-2bruA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg3 PROBABLE THIOSULFATE
SULFURTRANSFERASE

(Thermus
thermophilus) 		PF00581
(Rhodanese) 		4 THR A  57
GLY A  59
GLU A 105
HIS A  28
 None
 1.22A 5c0oH-2eg3A:
undetectable		 5c0oH-2eg3A:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 GLY A 239
GLU A 271
HIS A 275
ASP A 244
 None
 1.26A 5c0oH-2eklA:
7.2		 5c0oH-2eklA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuv PHOSPHOGLUCOMUTASE

(Salmonella
enterica) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 THR A  87
GLY A 237
HIS A 147
ASP A  86
 None
 1.20A 5c0oH-2fuvA:
undetectable		 5c0oH-2fuvA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Staphylococcus
aureus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 264
GLY A 279
GLU A 315
HIS A 304
 None
 1.13A 5c0oH-2gqdA:
undetectable		 5c0oH-2gqdA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1n OLIGOENDOPEPTIDASE F

(Geobacillus
stearothermophilus) 		PF01432
(Peptidase_M3) 		4 GLY A 349
GLU A 391
HIS A 356
ASP A 416
 None
None
ZN  A 601 (-3.3A)
None
 0.82A 5c0oH-2h1nA:
undetectable		 5c0oH-2h1nA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1

(Methanosarcina
barkeri) 		PF12176
(MtaB) 		4 THR A  18
GLY A  20
GLU A 345
ASP A 349
 None
 1.22A 5c0oH-2i2xA:
undetectable		 5c0oH-2i2xA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou MAJOR TROPISM
DETERMINANT P1

(Bordetella
virus BPP1) 		no annotation 4 THR A  41
GLY A  43
GLU A  24
ASP A  38
 None
 0.98A 5c0oH-2iouA:
undetectable		 5c0oH-2iouA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kho HEAT SHOCK PROTEIN
70

(Escherichia
coli) 		PF00012
(HSP70) 		4 THR A  12
GLY A 196
GLU A 230
HIS A 226
 None
 1.02A 5c0oH-2khoA:
undetectable		 5c0oH-2khoA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lr5 MICASIN

(Microsporum
canis) 		PF01097
(Defensin_2) 		4 THR A  34
GLY A  23
GLU A  10
HIS A  14
 None
 0.91A 5c0oH-2lr5A:
undetectable		 5c0oH-2lr5A:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		4 THR A 222
GLY A 247
GLU A 237
ASP A 230
 None
 0.92A 5c0oH-2o5vA:
undetectable		 5c0oH-2o5vA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		4 THR A 222
GLY A 247
GLU A 238
ASP A 230
 None
 1.23A 5c0oH-2o5vA:
undetectable		 5c0oH-2o5vA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Aspergillus
oryzae) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 THR A 277
GLY A 279
HIS A 310
ASP A 109
 None
 1.15A 5c0oH-2ps2A:
2.2		 5c0oH-2ps2A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwh SUCROSE ISOMERASE

([Pseudomonas]
mesoacidophila) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 THR A 432
GLY A 430
GLU A  36
ASP A  22
 None
None
None
CA  A7001 (-3.0A)
 1.00A 5c0oH-2pwhA:
undetectable		 5c0oH-2pwhA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qed HYDROXYACYLGLUTATHIO
NE HYDROLASE

(Salmonella
enterica) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		4 THR A 128
GLY A 126
GLU A  79
HIS A  54
 None
 0.97A 5c0oH-2qedA:
undetectable		 5c0oH-2qedA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qj8 MLR6093 PROTEIN

(Mesorhizobium
japonicum) 		PF04952
(AstE_AspA) 		4 THR A 145
GLY A 208
GLU A 205
HIS A 140
 None
 1.25A 5c0oH-2qj8A:
undetectable		 5c0oH-2qj8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlw RHAU

(Rhizobium
leguminosarum) 		PF05336
(rhaM) 		4 THR A  65
GLY A  39
GLU A   4
HIS A   6
 None
 1.25A 5c0oH-2qlwA:
undetectable		 5c0oH-2qlwA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlx L-RHAMNOSE
MUTAROTASE

(Rhizobium
leguminosarum) 		PF05336
(rhaM) 		4 THR A  65
GLY A  39
GLU A   4
HIS A   6
 None
 1.20A 5c0oH-2qlxA:
undetectable		 5c0oH-2qlxA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjt BETA-KETOACYL-ACP
SYNTHASE II

(Streptococcus
pneumoniae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 263
GLY A 278
GLU A 314
HIS A 303
 None
 1.22A 5c0oH-2rjtA:
undetectable		 5c0oH-2rjtA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x36 LON PROTEASE
HOMOLOG,
MITOCHONDRIAL

(Homo sapiens) 		PF05362
(Lon_C) 		4 THR A 777
GLY A 767
GLU A 781
HIS A 843
 None
 0.86A 5c0oH-2x36A:
2.1		 5c0oH-2x36A:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9x SELENOCYSTEINE LYASE

(Rattus
norvegicus) 		PF00266
(Aminotran_5) 		4 THR A 265
GLY A 260
GLU A 234
ASP A 239
 None
 0.96A 5c0oH-3a9xA:
2.6		 5c0oH-3a9xA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahm OLIGOPEPTIDASE

(Geobacillus sp.
MO-1) 		no annotation 4 GLY A 349
GLU A 391
HIS A 356
ASP A 416
 None
None
ZN  A 565 (-3.4A)
None
 0.89A 5c0oH-3ahmA:
undetectable		 5c0oH-3ahmA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clq UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF06545
(DUF1116) 		4 GLY A 250
GLU A 242
HIS A 244
ASP A 283
 None
 1.17A 5c0oH-3clqA:
undetectable		 5c0oH-3clqA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		PF00632
(HECT) 		4 GLY A4302
GLU A4147
HIS A4339
ASP A4145
 NA  A5001 ( 4.9A)
None
None
None
 1.10A 5c0oH-3g1nA:
undetectable		 5c0oH-3g1nA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goc ENDONUCLEASE V

(Streptomyces
avermitilis) 		PF04493
(Endonuclease_5) 		4 THR A 213
GLY A  44
GLU A  93
ASP A 114
 None
None
None
MG  A 302 (-3.9A)
 1.09A 5c0oH-3gocA:
undetectable		 5c0oH-3gocA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 THR C 277
GLY C 272
GLU C 246
ASP C 251
 None
 1.14A 5c0oH-3gzdC:
3.2		 5c0oH-3gzdC:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsi PHOSPHATIDYLSERINE
SYNTHASE

(Haemophilus
influenzae) 		PF13091
(PLDc_2) 		4 THR A 275
GLY A 364
GLU A 389
HIS A 139
 None
 1.16A 5c0oH-3hsiA:
2.1		 5c0oH-3hsiA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0z PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Streptococcus
pneumoniae) 		PF01380
(SIS) 		4 THR A 289
GLY A 287
GLU A 328
ASP A 318
 None
 0.69A 5c0oH-3i0zA:
2.7		 5c0oH-3i0zA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3w PHOSPHOGLUCOSAMINE
MUTASE

(Francisella
tularensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 THR A 283
GLY A 279
HIS A 326
ASP A 258
 None
None
SEP  A 101 ( 3.7A)
None
 0.95A 5c0oH-3i3wA:
undetectable		 5c0oH-3i3wA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgx PUTATIVE P450
MONOOXYGENASE

(Amycolatopsis
balhimycina) 		PF00067
(p450) 		4 THR A 139
GLY A 142
HIS A 249
ASP A 136
 None
None
GOL  A 401 (-4.3A)
None
 1.08A 5c0oH-3mgxA:
undetectable		 5c0oH-3mgxA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672

(Caulobacter
vibrioides) 		PF01979
(Amidohydro_1) 		4 THR A 301
GLY A 305
GLU A 312
ASP A 318
 None
None
None
M3R  A 430 (-3.8A)
 1.04A 5c0oH-3mtwA:
undetectable		 5c0oH-3mtwA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE

(Ruegeria sp.
TM1040) 		PF04952
(AstE_AspA) 		4 THR A 149
GLY A 213
GLU A 209
HIS A 144
 None
 1.18A 5c0oH-3na6A:
undetectable		 5c0oH-3na6A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 263
GLY A 278
GLU A 314
HIS A 303
 None
 1.16A 5c0oH-3o04A:
undetectable		 5c0oH-3o04A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 264
GLY A 277
GLU A 310
HIS A 299
 None
 1.14A 5c0oH-3oytA:
undetectable		 5c0oH-3oytA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbd 3-DEHYDROQUINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01761
(DHQ_synthase) 		4 THR A 110
GLY A 106
HIS A 265
ASP A 111
 None
NAD  A 400 (-3.1A)
None
NAD  A 400 (-3.1A)
 1.25A 5c0oH-3qbdA:
5.1		 5c0oH-3qbdA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnk PUTATIVE LIPOPROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 THR A 332
GLY A 334
HIS A 350
ASP A 329
 None
 1.19A 5c0oH-3qnkA:
undetectable		 5c0oH-3qnkA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsq CAPSID POLYPROTEIN

(Mamastrovirus 1) 		PF12226
(Astro_capsid_p) 		4 THR A 544
GLY A 585
GLU A 499
ASP A 517
 None
 1.06A 5c0oH-3qsqA:
undetectable		 5c0oH-3qsqA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0f BETA-KETOACYL
SYNTHASE

(Brucella
abortus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 261
GLY A 274
GLU A 307
HIS A 296
 None
 1.05A 5c0oH-3u0fA:
undetectable		 5c0oH-3u0fA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgf ARYLAMINE
N-ACETYLTRANSFERASE
NAT

(Mycobacterium
tuberculosis) 		PF00797
(Acetyltransf_2) 		4 THR A 234
GLY A 232
GLU A 152
HIS A 151
 None
 1.10A 5c0oH-4bgfA:
undetectable		 5c0oH-4bgfA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5t MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN

(Labrenzia
alexandrii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 THR A  89
GLY A  92
GLU A 272
ASP A  87
 None
 1.27A 5c0oH-4e5tA:
undetectable		 5c0oH-4e5tA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A  55
GLY A  57
HIS A 111
ASP A 113
 None
None
None
EDO  A 408 (-3.3A)
 1.00A 5c0oH-4ej6A:
8.2		 5c0oH-4ej6A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Burkholderia
vietnamiensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 273
GLY A 288
GLU A 324
HIS A 313
 None
None
None
N32  A 501 (-4.0A)
 1.21A 5c0oH-4f32A:
undetectable		 5c0oH-4f32A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9d POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Escherichia
coli) 		PF01522
(Polysacc_deac_1)
PF14883
(GHL13) 		4 THR A 535
GLY A 461
GLU A 275
ASP A 565
 None
 1.23A 5c0oH-4f9dA:
undetectable		 5c0oH-4f9dA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gve NUCLEOPROTEIN

(Tacaribe
mammarenavirus) 		PF17290
(Arena_ncap_C) 		4 GLY A 460
GLU A 388
HIS A 530
ASP A 463
 None
MG  A 602 (-2.5A)
None
None
 1.24A 5c0oH-4gveA:
undetectable		 5c0oH-4gveA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD

(Legionella
pneumophila) 		no annotation 4 THR A 252
GLY A 194
GLU A 212
ASP A 110
 None
None
None
MG  A 401 ( 2.8A)
 1.25A 5c0oH-4iikA:
undetectable		 5c0oH-4iikA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 THR A 210
GLU A 335
HIS A 310
ASP A 168
 None
 1.21A 5c0oH-4j3zA:
2.1		 5c0oH-4j3zA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Rickettsia
rickettsii) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 278
GLY A 293
GLU A 329
HIS A 318
 None
 1.21A 5c0oH-4jgaA:
undetectable		 5c0oH-4jgaA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycobacterium
tuberculosis) 		PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1) 		4 THR A 215
GLY A 217
HIS A 194
ASP A 211
 None
 1.24A 5c0oH-4kbmA:
undetectable		 5c0oH-4kbmA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 262
GLY A 277
GLU A 313
HIS A 302
 None
 1.17A 5c0oH-4ls5A:
undetectable		 5c0oH-4ls5A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvu OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Burkholderia
thailandensis) 		PF13561
(adh_short_C2) 		4 THR A  39
GLY A  37
GLU A  47
HIS A  48
 None
 1.18A 5c0oH-4lvuA:
7.2		 5c0oH-4lvuA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m01 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		no annotation 4 THR A 479
GLY A 329
HIS A 325
ASP A 290
 None
 1.17A 5c0oH-4m01A:
undetectable		 5c0oH-4m01A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlg BETA-XYLOSIDASE

(uncultured
organism) 		PF04616
(Glyco_hydro_43) 		4 THR A 298
GLY A 270
GLU A 223
HIS A 274
 None
None
SO4  A 402 (-3.3A)
CA  A 401 ( 3.9A)
 1.18A 5c0oH-4mlgA:
undetectable		 5c0oH-4mlgA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4of0 PROTEIN SYG-1,
ISOFORM B

(Caenorhabditis
elegans) 		PF07679
(I-set)
PF08205
(C2-set_2) 		4 THR A  95
GLY A  37
GLU A  90
ASP A  98
 None
 1.25A 5c0oH-4of0A:
undetectable		 5c0oH-4of0A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7a HISTONE-BINDING
PROTEIN RBBP4

(Homo sapiens) 		PF00400
(WD40)
PF12265
(CAF1C_H4-bd) 		4 THR B 297
GLY B 292
GLU B 275
ASP B 295
 None
 1.18A 5c0oH-4r7aB:
undetectable		 5c0oH-4r7aB:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1b LMO1466 PROTEIN

(Listeria
monocytogenes) 		PF01966
(HD) 		4 THR A 581
GLY A 546
GLU A 556
HIS A 514
 None
None
2BA  A 803 (-2.9A)
FE  A 802 ( 3.4A)
 1.17A 5c0oH-4s1bA:
undetectable		 5c0oH-4s1bA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A  56
GLY A  58
HIS A  51
ASP A 114
 None
 1.16A 5c0oH-4uekA:
6.9		 5c0oH-4uekA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 GLY A 651
GLU A 233
HIS A 150
ASP A 727
 None
 1.18A 5c0oH-4wjlA:
undetectable		 5c0oH-4wjlA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio cholerae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 261
GLY A 274
GLU A 306
HIS A 295
 None
 1.06A 5c0oH-4xoxA:
undetectable		 5c0oH-4xoxA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1b ANTE

(Streptomyces
sp. NRRL 2288) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 328
GLU A 300
HIS A 301
ASP A 305
 None
None
NAP  A 501 (-3.2A)
NAP  A 501 (-3.2A)
 1.06A 5c0oH-4y1bA:
6.6		 5c0oH-4y1bA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn8 RESPONSE REGULATOR
CHRA

(Corynebacterium
diphtheriae) 		PF00072
(Response_reg)
PF00196
(GerE) 		4 THR A  56
GLY A  58
HIS A  10
ASP A  35
 None
None
MG  A 204 (-3.5A)
None
 1.24A 5c0oH-4yn8A:
undetectable		 5c0oH-4yn8A:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 THR A 864
GLY A 787
HIS A 929
ASP A 870
 None
 1.26A 5c0oH-4zdnA:
undetectable		 5c0oH-4zdnA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zel DOPAMINE
BETA-HYDROXYLASE

(Homo sapiens) 		PF01082
(Cu2_monooxygen)
PF03351
(DOMON)
PF03712
(Cu2_monoox_C) 		4 THR A 254
GLY A 256
HIS A 262
ASP A 345
 None
 1.17A 5c0oH-4zelA:
undetectable		 5c0oH-4zelA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT
PUTATIVE
OXIDOREDUCTASE
IRON-SULFUR SUBUNIT

(Sulfurisphaera
tokodaii;
Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
PF00111
(Fer2)
PF01799
(Fer2_2) 		4 THR C  41
GLY C  39
HIS C  33
ASP A  25
 None
 1.12A 5c0oH-4zohC:
undetectable		 5c0oH-4zohC:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brq GLYCOSIDE HYDROLASE
FAMILY 13

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 THR A 432
GLY A 430
GLU A  38
ASP A  24
 None
None
None
MG  A 601 (-3.1A)
 0.98A 5c0oH-5brqA:
undetectable		 5c0oH-5brqA:
19.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI

(Thermus
thermophilus) 		PF08704
(GCD14) 		4 THR A  77
GLY A 106
GLU A 125
HIS A 130
 None
 0.58A 5c0oH-5c1iA:
31.7		 5c0oH-5c1iA:
98.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
BETA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		PF02239
(Cytochrom_D1) 		4 THR B 313
GLY B 305
HIS B 310
ASP B 287
 None
 1.19A 5c0oH-5c2vB:
undetectable		 5c0oH-5c2vB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cpc SECRETED EFFECTOR
PROTEIN SOPD

(Salmonella
enterica) 		PF11047
(SopD) 		4 GLY A  35
GLU A 163
HIS A 161
ASP A  38
 None
 1.25A 5c0oH-5cpcA:
undetectable		 5c0oH-5cpcA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do8 LMO0184 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 THR B 431
GLY B 429
GLU B  36
ASP B  22
 None
 0.98A 5c0oH-5do8B:
undetectable		 5c0oH-5do8B:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE

(Bacillus
subtilis) 		PF00698
(Acyl_transf_1) 		4 THR A 120
GLY A 190
GLU A  55
HIS A  53
 None
 1.14A 5c0oH-5dz7A:
undetectable		 5c0oH-5dz7A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erb POLYKETIDE SYNTHASE

(Bacillus
amyloliquefaciens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 THR A 320
GLY A 243
HIS A 385
ASP A 326
 None
 1.18A 5c0oH-5erbA:
undetectable		 5c0oH-5erbA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz TUBULIN GAMMA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 THR C 273
GLY C 374
GLU C 327
HIS C 289
 None
 1.14A 5c0oH-5flzC:
undetectable		 5c0oH-5flzC:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hph HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL

(Homo sapiens) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		4 THR A 249
GLY A 160
GLU A 142
HIS A 144
 None
 1.07A 5c0oH-5hphA:
undetectable		 5c0oH-5hphA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ify GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		4 THR A  56
GLY A  11
HIS A  21
ASP A  59
 None
TRH  A 500 (-4.9A)
None
None
 1.25A 5c0oH-5ifyA:
undetectable		 5c0oH-5ifyA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktk POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		4 THR A 122
GLY A 137
GLU A 398
ASP A 160
 None
 1.16A 5c0oH-5ktkA:
5.7		 5c0oH-5ktkA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME

(Pseudomonas
savastanoi) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 THR A 190
GLU A 285
HIS A 169
ASP A 253
 None
 1.17A 5c0oH-5lunA:
undetectable		 5c0oH-5lunA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu7 COATOMER SUBUNIT
BETA
COATOMER SUBUNIT
DELTA-LIKE PROTEIN

(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		PF01602
(Adaptin_N)
PF01217
(Clat_adaptor_s) 		4 THR A 119
GLY A 117
GLU B 141
ASP A 107
 None
 1.19A 5c0oH-5mu7A:
undetectable		 5c0oH-5mu7A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzh DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1

(Chlamydomonas
reinhardtii) 		PF00400
(WD40) 		4 THR A 202
GLY A 197
GLU A 181
ASP A 200
 None
 1.26A 5c0oH-5mzhA:
undetectable		 5c0oH-5mzhA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o99 SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3

(Rattus
norvegicus) 		no annotation 4 THR B 516
GLY B 514
GLU B 495
HIS B 492
 None
 1.16A 5c0oH-5o99B:
undetectable		 5c0oH-5o99B:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT
ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile;
Clostridioides
difficile) 		no annotation
no annotation 		4 THR C  65
GLY C  67
GLU B 201
ASP C 306
 None
 1.18A 5c0oH-5ol2C:
undetectable		 5c0oH-5ol2C:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B

(Methanothermobacter
sp. CaT2) 		PF00384
(Molybdopterin) 		4 THR B  92
GLU B 366
HIS B 368
ASP B 414
 MGD  B 503 ( 4.9A)
MGD  B 503 (-2.9A)
MGD  B 503 (-4.4A)
MGD  B 503 (-3.0A)
 1.27A 5c0oH-5t5iB:
2.1		 5c0oH-5t5iB:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpu 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Acinetobacter
baumannii) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 GLY A 120
GLU A 131
HIS A 130
ASP A 155
 None
None
EDO  A 607 (-3.8A)
None
 1.22A 5c0oH-5vpuA:
4.5		 5c0oH-5vpuA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE

(Eimeria tenella) 		no annotation 4 THR A 460
GLY A 457
GLU A 361
HIS A 411
 None
None
HFG  A1003 (-2.9A)
HFG  A1003 ( 4.7A)
 1.25A 5c0oH-5xipA:
undetectable		 5c0oH-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6am0 KLLA0F23980P
KLLA0A01474P

(Kluyveromyces
lactis;
Kluyveromyces
lactis) 		no annotation
no annotation 		4 THR C 366
GLY A 136
GLU A  46
HIS A  43
 None
 1.22A 5c0oH-6am0C:
undetectable		 5c0oH-6am0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byx SHORT ULVAN LYASE

(Alteromonas sp.
LOR) 		no annotation 4 THR A 134
GLY A 138
HIS A 146
ASP A 165
 None
 1.26A 5c0oH-6byxA:
undetectable		 5c0oH-6byxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fax TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER 5

(Homo sapiens) 		no annotation 4 GLY R  44
GLU R  74
HIS R  76
ASP R  69
 None
 1.25A 5c0oH-6faxR:
undetectable		 5c0oH-6faxR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fay ODZ3 PROTEIN

(Mus musculus) 		no annotation 4 THR A1449
GLY A1430
GLU A1104
ASP A1451
 None
 1.20A 5c0oH-6fayA:
undetectable		 5c0oH-6fayA:
undetectable