SIMILAR PATTERNS OF AMINO ACIDS FOR 5BYK_A_OAQA302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE

(Human
alphaherpesvirus
2) 		PF00716
(Peptidase_S21) 		5 PRO A  51
LEU A  55
VAL A  74
VAL A  73
LEU A 168
 None
 1.15A 5bykA-1at3A:
0.0		 5bykA-1at3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz4 NAD-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		5 PRO A 386
ILE A 323
LEU A 308
VAL A 415
LEU A 288
 None
 1.03A 5bykA-1gz4A:
1.2		 5bykA-1gz4A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7p NADH-CYTOCHROME B5
REDUCTASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 PRO A 275
ILE A 183
LEU A 217
PHE A 207
THR A  56
 None
 1.23A 5bykA-1i7pA:
0.9		 5bykA-1i7pA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw5 NAGD PROTEIN,
PUTATIVE

(Thermotoga
maritima) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 ILE A 165
VAL A 117
VAL A 118
LEU A 125
THR A 146
 None
 1.29A 5bykA-1pw5A:
0.2		 5bykA-1pw5A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2e EXOCELLOBIOHYDROLASE
I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		5 ILE A 421
VAL A 290
VAL A 291
LEU A 362
THR A 429
 None
 1.20A 5bykA-1q2eA:
undetectable		 5bykA-1q2eA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6w MONOAMINE OXIDASE
REGULATORY PROTEIN,
PUTATIVE

(Archaeoglobus
fulgidus) 		PF01575
(MaoC_dehydratas) 		5 MET A  78
ILE A  74
LEU A  27
LEU A  70
THR A  34
 None
 1.21A 5bykA-1q6wA:
0.0		 5bykA-1q6wA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6w MONOAMINE OXIDASE
REGULATORY PROTEIN,
PUTATIVE

(Archaeoglobus
fulgidus) 		PF01575
(MaoC_dehydratas) 		5 MET A  78
ILE A  74
LEU A  27
LEU A  70
THR A  38
 None
 1.28A 5bykA-1q6wA:
0.0		 5bykA-1q6wA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q9h CELLOBIOHYDROLASE I
CATALYTIC DOMAIN

(Rasamsonia
emersonii) 		PF00840
(Glyco_hydro_7) 		5 ILE A 425
VAL A 285
VAL A 286
LEU A 366
THR A 433
 None
 1.27A 5bykA-1q9hA:
undetectable		 5bykA-1q9hA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r47 ALPHA-GALACTOSIDASE
A

(Homo sapiens) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		5 ILE A 289
LEU A 324
VAL A 254
LEU A 286
THR A 246
 None
 1.28A 5bykA-1r47A:
0.1		 5bykA-1r47A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r82 GLYCOPROTEIN-FUCOSYL
GALACTOSIDE
ALPHA-GALACTOSYLTRAN
SFERASE

(Homo sapiens) 		PF03414
(Glyco_transf_6) 		5 ILE A 224
LEU A 324
VAL A 210
LEU A 225
PHE A 229
 None
AOG  A 452 ( 4.2A)
None
None
None
 1.08A 5bykA-1r82A:
0.0		 5bykA-1r82A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su1 HYPOTHETICAL PROTEIN
YFCE

(Escherichia
coli) 		PF12850
(Metallophos_2) 		5 ILE A  34
VAL A  56
VAL A  57
LEU A  32
PHE A  85
 None
 0.85A 5bykA-1su1A:
undetectable		 5bykA-1su1A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp7 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		5 PRO A 261
ILE A  90
VAL A 253
LEU A  88
MET A 298
 None
 1.28A 5bykA-1tp7A:
undetectable		 5bykA-1tp7A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		5 PRO A 161
ILE A  58
LEU A 164
VAL A  11
LEU A  15
 None
 1.23A 5bykA-1v43A:
undetectable		 5bykA-1v43A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vki HYPOTHETICAL PROTEIN
ATU3699

(Agrobacterium
fabrum) 		PF04073
(tRNA_edit) 		5 ILE A  21
VAL A 108
LEU A  19
THR A 144
THR A 158
 None
 1.17A 5bykA-1vkiA:
undetectable		 5bykA-1vkiA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvi PUTATIVE
PHOSPHATASES
INVOLVED IN
N-ACETYL-GLUCOSAMINE
CATABOLISM

(Streptococcus
mutans) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 ILE A1164
VAL A1116
VAL A1117
LEU A1124
THR A1145
 None
 1.29A 5bykA-1wviA:
undetectable		 5bykA-1wviA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE

(Chlorobaculum
tepidum) 		PF04371
(PAD_porph) 		5 HIS A 217
ILE A 160
VAL A 154
LEU A 197
THR A 151
 None
 1.26A 5bykA-1xknA:
undetectable		 5bykA-1xknA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zp2 RNA POLYMERASE II
HOLOENZYME
CYCLIN-LIKE SUBUNIT

(Schizosaccharomyces
pombe) 		PF00134
(Cyclin_N) 		5 PRO A 138
ILE A 203
LEU A 180
LEU A 200
THR A 195
 None
 1.31A 5bykA-1zp2A:
undetectable		 5bykA-1zp2A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cc0 ACETYL-XYLAN
ESTERASE

(Streptomyces
lividans) 		PF01522
(Polysacc_deac_1) 		5 ILE A 165
LEU A  26
THR A 171
MET A 154
THR A  10
 None
 1.18A 5bykA-2cc0A:
undetectable		 5bykA-2cc0A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		5 ILE A 471
LEU A 974
VAL A 483
VAL A 484
LEU A 945
 None
 1.30A 5bykA-2eyqA:
undetectable		 5bykA-2eyqA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		5 PRO A1719
ILE A1732
VAL A1668
VAL A1724
LEU A1916
 None
 1.17A 5bykA-2ix8A:
undetectable		 5bykA-2ix8A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mki CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 4

(Homo sapiens) 		PF16367
(RRM_7) 		5 PRO A  73
ILE A 151
LEU A  72
VAL A 139
PHE A  85
 None
 1.29A 5bykA-2mkiA:
undetectable		 5bykA-2mkiA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nys AGR_C_3712P

(Agrobacterium
fabrum) 		PF04386
(SspB) 		5 ILE A  66
LEU A  44
VAL A  50
LEU A  86
THR A  45
 None
 1.26A 5bykA-2nysA:
undetectable		 5bykA-2nysA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		5 ILE A 221
VAL A 137
VAL A 134
PHE A 751
THR A 118
 None
 1.32A 5bykA-2pi5A:
undetectable		 5bykA-2pi5A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Melanocarpus
albomyces) 		PF00840
(Glyco_hydro_7) 		5 ILE A 419
VAL A 288
VAL A 289
LEU A 361
THR A 427
 None
 1.19A 5bykA-2rfzA:
undetectable		 5bykA-2rfzA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3z PUTATIVE DEACETYLASE

(Streptococcus
mutans) 		PF01522
(Polysacc_deac_1) 		5 ILE A 297
VAL A 278
LEU A 129
PHE A 307
MET A 280
 None
 1.20A 5bykA-2w3zA:
undetectable		 5bykA-2w3zA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsu PUTATIVE FIBER
PROTEIN

(Porcine
mastadenovirus
B) 		PF00337
(Gal-bind_lectin) 		5 PRO A 626
ILE A 637
VAL A 596
LEU A 579
THR A 654
 None
 1.31A 5bykA-2wsuA:
undetectable		 5bykA-2wsuA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN

(Bordetella
bronchiseptica) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 PRO A 448
LEU A 435
VAL A 507
LEU A 424
THR A 516
 None
 1.27A 5bykA-2x0qA:
undetectable		 5bykA-2x0qA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yok EXOGLUCANASE 1

(Trichoderma
harzianum) 		PF00840
(Glyco_hydro_7) 		5 ILE A 434
VAL A 303
VAL A 304
LEU A 375
THR A 442
 None
 1.20A 5bykA-2yokA:
undetectable		 5bykA-2yokA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a68 FERRITIN-4,
CHLOROPLASTIC

(Glycine max) 		PF00210
(Ferritin) 		5 ILE A 181
LEU A 142
VAL A  59
THR A 143
MET A  66
 None
None
None
CA  A 214 ( 4.4A)
None
 1.22A 5bykA-3a68A:
undetectable		 5bykA-3a68A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1

(Homo sapiens) 		PF12697
(Abhydrolase_6) 		5 ILE P 150
VAL P 138
VAL P 135
THR P 165
MET P 142
 None
 1.25A 5bykA-3c5wP:
1.8		 5bykA-3c5wP:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqq PUTATIVE TRNA
SYNTHASE

(Salmonella
enterica) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 PRO A  40
HIS A 393
ILE A 373
VAL A  29
LEU A 398
 None
 1.24A 5bykA-3dqqA:
1.9		 5bykA-3dqqA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejw SMLSRB

(Sinorhizobium
meliloti) 		PF13407
(Peripla_BP_4) 		5 PRO A  42
ILE A   7
LEU A  10
VAL A  67
LEU A  62
 None
 1.12A 5bykA-3ejwA:
undetectable		 5bykA-3ejwA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		5 ILE A 552
VAL A 584
PHE A 548
THR A 539
MET A 591
 None
 1.08A 5bykA-3g06A:
undetectable		 5bykA-3g06A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gas HEME OXYGENASE

(Helicobacter
pylori) 		PF01243
(Putative_PNPOx)
PF10615
(DUF2470) 		5 MET A   9
VAL A  38
LEU A  21
THR A  71
THR A  52
 None
 1.31A 5bykA-3gasA:
undetectable		 5bykA-3gasA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd5 ORNITHINE
CARBAMOYLTRANSFERASE

(Gloeobacter
violaceus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ILE A 129
LEU A 132
VAL A 142
PHE A  66
THR A  62
 None
 1.24A 5bykA-3gd5A:
undetectable		 5bykA-3gd5A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn2 2-DEHYDROPANTOATE
2-REDUCTASE

(Geobacter
metallireducens) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 MET A  68
ILE A   3
VAL A  73
VAL A   6
LEU A  19
 None
 1.09A 5bykA-3hn2A:
undetectable		 5bykA-3hn2A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2m ORF59

(Human
gammaherpesvirus
8) 		PF04929
(Herpes_DNAp_acc) 		5 ILE X  19
VAL X  48
LEU X  15
PHE X  99
THR X  95
 None
 1.27A 5bykA-3i2mX:
undetectable		 5bykA-3i2mX:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2v ADENYLYLTRANSFERASE
AND
SULFURTRANSFERASE
MOCS3

(Homo sapiens) 		PF00581
(Rhodanese) 		5 HIS A  17
ILE A  74
VAL A 108
VAL A   2
LEU A  91
 None
 1.02A 5bykA-3i2vA:
undetectable		 5bykA-3i2vA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icl EAL/GGDEF DOMAIN
PROTEIN

(Methylococcus
capsulatus) 		PF00990
(GGDEF) 		5 ILE A 116
LEU A 105
VAL A  37
LEU A  47
THR A  59
 None
 1.06A 5bykA-3iclA:
undetectable		 5bykA-3iclA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j31 COAT PROTEIN

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 6 PRO A  58
ILE A 136
LEU A  61
VAL A 115
LEU A 134
PHE A 151
 None
 1.48A 5bykA-3j31A:
undetectable		 5bykA-3j31A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ja7 PORTAL PROTEIN GP20

(Escherichia
virus T4) 		PF07230
(Peptidase_S80) 		5 ILE A 171
LEU A 137
VAL A 235
VAL A 236
LEU A 428
 None
 1.13A 5bykA-3ja7A:
undetectable		 5bykA-3ja7A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jze DIHYDROOROTASE

(Salmonella
enterica) 		PF01979
(Amidohydro_1) 		5 ILE A  63
VAL A  18
PHE A  73
THR A  33
THR A 100
 None
 1.30A 5bykA-3jzeA:
undetectable		 5bykA-3jzeA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k94 THIAMIN
PYROPHOSPHOKINASE

(Geobacillus
thermodenitrificans) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		5 PRO A  10
ILE A 126
LEU A  13
LEU A 116
MET A  81
 None
 1.27A 5bykA-3k94A:
undetectable		 5bykA-3k94A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb6 D-LACTATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ILE A 198
LEU A 252
VAL A 234
VAL A 235
LEU A 191
 None
 1.25A 5bykA-3kb6A:
undetectable		 5bykA-3kb6A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1w RABGDI PROTEIN

(Plasmodium
falciparum) 		PF00996
(GDI) 		5 ILE A 242
VAL A  87
LEU A  14
PHE A 246
THR A  93
 None
 1.17A 5bykA-3p1wA:
undetectable		 5bykA-3p1wA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pc3 CG1753, ISOFORM A

(Drosophila
melanogaster) 		PF00291
(PALP)
PF00571
(CBS) 		5 ILE A 209
VAL A 221
VAL A 222
LEU A  58
THR A 229
 None
None
None
None
P1T  A 702 (-3.6A)
 1.12A 5bykA-3pc3A:
undetectable		 5bykA-3pc3A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpx FAB C2507 HEAVY
CHAIN
FAB C2507 LIGHT
CHAIN

(Homo sapiens;
Rattus
norvegicus;
Homo sapiens;
Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 PRO H 153
VAL H 156
LEU L  40
THR H 114
THR H 171
 None
None
None
SO4  H 234 (-3.6A)
None
 1.09A 5bykA-3qpxH:
undetectable		 5bykA-3qpxH:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqr NON-LEGUME
HEMOGLOBIN

(Parasponia
andersonii) 		PF00042
(Globin) 		5 MET A 157
ILE A 153
LEU A 149
PHE A 115
THR A  73
 None
None
HEM  A 163 (-4.1A)
HEM  A 163 ( 4.3A)
HEM  A 163 (-4.0A)
 0.99A 5bykA-3qqrA:
undetectable		 5bykA-3qqrA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qre ENOYL-COA HYDRATASE,
ECHA12_1

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 PRO A 101
ILE A 160
VAL A 105
LEU A 164
THR A 232
 None
 1.12A 5bykA-3qreA:
undetectable		 5bykA-3qreA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tj0 NUCLEOPROTEIN

(Influenza B
virus) 		PF00506
(Flu_NP) 		5 VAL A 323
VAL A 322
LEU A 296
THR A 227
MET A 504
 None
 1.12A 5bykA-3tj0A:
undetectable		 5bykA-3tj0A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tz1 TROPONIN C
TROPONIN I

(Chlamys
nipponensis;
Chlamys
nipponensis) 		PF13499
(EF-hand_7)
no annotation 		5 MET B 157
ILE B 156
VAL A  93
LEU A 107
PHE A 143
 None
 1.30A 5bykA-3tz1B:
undetectable		 5bykA-3tz1B:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcr PUTATIVE KDPG
(2-KETO-3-DEOXY-6-PH
OSPHOGLUCONATE)
ALDOLASE

(Oleispira
antarctica) 		PF01081
(Aldolase) 		5 PRO A 116
ILE A 182
LEU A 135
VAL A 113
THR A 133
 None
 1.22A 5bykA-3vcrA:
undetectable		 5bykA-3vcrA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD

(Thermococcus
kodakarensis) 		PF01924
(HypD) 		5 ILE B  70
VAL B  37
PHE B 149
THR B 180
THR B 361
 None
 1.21A 5bykA-3vysB:
undetectable		 5bykA-3vysB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM7

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF01423
(LSM)
PF01423
(LSM) 		5 PRO A  75
ILE C  46
LEU C  85
VAL C  87
THR C  92
 None
 1.30A 5bykA-4emkA:
undetectable		 5bykA-4emkA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h63 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 11
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 22

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		no annotation
PF06179
(Med22) 		5 ILE V  77
LEU K  77
VAL K  84
THR V  14
THR V  83
 None
 1.29A 5bykA-4h63V:
undetectable		 5bykA-4h63V:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hi4 AEROTAXIS TRANSDUCER
AER2

(Pseudomonas
aeruginosa) 		PF13188
(PAS_8) 		5 HIS A 234
LEU A 243
VAL A 281
VAL A 266
MET A 187
 HEM  A 301 ( 3.6A)
HEM  A 301 ( 3.7A)
HEM  A 301 (-4.1A)
HEM  A 301 ( 4.5A)
HEM  A 301 (-2.8A)
 1.19A 5bykA-4hi4A:
undetectable		 5bykA-4hi4A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5s PUTATIVE HISTIDINE
KINASE COVS
VICK-LIKE PROTEIN

(Streptococcus
mutans) 		PF00512
(HisKA)
PF00989
(PAS)
PF02518
(HATPase_c) 		5 ILE A 139
VAL A 161
LEU A 108
PHE A 178
THR A 157
 None
 1.21A 5bykA-4i5sA:
undetectable		 5bykA-4i5sA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j16 NAD/NADP
TRANSHYDROGENASE
ALPHA SUBUNIT 1

(Thermus
thermophilus) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 PRO A  77
LEU A  81
VAL A 114
VAL A  91
MET A 358
 None
 1.00A 5bykA-4j16A:
undetectable		 5bykA-4j16A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2o UDP-N-ACETYLGLUCOSAM
INE
4,6-DEHYDRATASE/5-EP
IMERASE

(Acinetobacter
baumannii) 		PF02719
(Polysacc_synt_2)
PF08485
(Polysacc_syn_2C) 		5 ILE A 175
LEU A 202
LEU A 238
THR A 201
THR A 335
 None
 1.23A 5bykA-4j2oA:
2.5		 5bykA-4j2oA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4owt INTEGRATOR COMPLEX
SUBUNIT 3

(Homo sapiens) 		PF10189
(Ints3) 		5 ILE A 129
LEU A 123
VAL A 146
VAL A 149
PHE A  94
 None
 1.29A 5bykA-4owtA:
undetectable		 5bykA-4owtA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4puf E3 UBIQUITIN-PROTEIN
LIGASE SLRP

(Salmonella
enterica) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		5 ILE A 369
LEU A 327
VAL A 353
LEU A 390
THR A 329
 None
 1.27A 5bykA-4pufA:
undetectable		 5bykA-4pufA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0c VIRULENCE SENSOR
PROTEIN BVGS

(Bordetella
pertussis) 		PF00497
(SBP_bac_3) 		5 ILE A 215
LEU A 203
VAL A 236
VAL A 235
THR A 221
 None
 1.29A 5bykA-4q0cA:
undetectable		 5bykA-4q0cA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1

(Homo sapiens) 		PF05609
(LAP1C) 		5 ILE A 564
LEU A 490
LEU A 411
PHE A 481
THR A 489
 None
 1.19A 5bykA-4tvsA:
undetectable		 5bykA-4tvsA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xg0 UNCHARACTERIZED
PROTEIN

(Bordetella
bronchiseptica) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 ILE A 353
LEU A 348
VAL A 334
VAL A 333
LEU A 355
 None
 1.07A 5bykA-4xg0A:
undetectable		 5bykA-4xg0A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y63 HISTO-BLOOD GROUP
ABO SYSTEM
TRANSFERASE

(Homo sapiens) 		PF03414
(Glyco_transf_6) 		5 ILE A 224
LEU A 324
VAL A 210
LEU A 225
PHE A 229
 None
 1.00A 5bykA-4y63A:
undetectable		 5bykA-4y63A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida) 		PF00753
(Lactamase_B) 		5 PRO A 151
ILE A 263
VAL A 106
VAL A 103
LEU A 264
 None
 1.23A 5bykA-4yslA:
undetectable		 5bykA-4yslA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi5 P91

(metagenome) 		PF01738
(DLH) 		5 MET A  64
LEU A  60
PHE A  35
THR A 123
THR A 102
 None
 1.30A 5bykA-4zi5A:
undetectable		 5bykA-4zi5A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyj DNMZ

(Streptomyces
peucetius) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 PRO A  72
MET A 136
LEU A 133
VAL A  80
LEU A 104
 None
 1.26A 5bykA-4zyjA:
undetectable		 5bykA-4zyjA:
21.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5byk SULFOTRANSFERASE

(Schistosoma
mansoni) 		no annotation 6 PRO A  16
HIS A  37
LEU A  92
VAL A 127
VAL A 128
THR A 234
 OAQ  A 302 (-4.4A)
OAQ  A 302 ( 4.6A)
OAQ  A 302 (-4.0A)
OAQ  A 302 (-4.9A)
OAQ  A 302 (-4.0A)
None
 1.37A 5bykA-5bykA:
46.1		 5bykA-5bykA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5byk SULFOTRANSFERASE

(Schistosoma
mansoni) 		no annotation 12 PRO A  16
HIS A  37
MET A  38
ILE A  42
LEU A  92
VAL A 127
VAL A 128
LEU A 147
PHE A 153
THR A 157
MET A 233
THR A 237
 OAQ  A 302 (-4.4A)
OAQ  A 302 ( 4.6A)
OAQ  A 302 (-4.3A)
None
OAQ  A 302 (-4.0A)
OAQ  A 302 (-4.9A)
OAQ  A 302 (-4.0A)
None
OAQ  A 302 ( 4.8A)
OAQ  A 302 (-2.6A)
None
OAQ  A 302 (-3.8A)
 0.22A 5bykA-5bykA:
46.1		 5bykA-5bykA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb0 UNIVERSAL STRESS
PROTEIN E

(Escherichia
coli) 		PF00582
(Usp) 		5 ILE A 289
LEU A 281
VAL A 142
LEU A 292
THR A 270
 None
 1.20A 5bykA-5cb0A:
undetectable		 5bykA-5cb0A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dql ISOCITRATE LYASE 1

(Mycobacterium
tuberculosis) 		PF00463
(ICL) 		5 ILE A 150
VAL A  78
VAL A  81
LEU A  90
THR A  73
 None
 1.06A 5bykA-5dqlA:
undetectable		 5bykA-5dqlA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejs MYOSIN-I HEAVY CHAIN

(Dictyostelium
discoideum) 		PF00373
(FERM_M)
PF00784
(MyTH4)
PF09380
(FERM_C) 		5 PRO A2042
ILE A1957
LEU A1953
PHE A1988
THR A1987
 None
 1.12A 5bykA-5ejsA:
undetectable		 5bykA-5ejsA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejy MYOSIN-I HEAVY CHAIN

(Dictyostelium
discoideum) 		PF00784
(MyTH4) 		5 ILE A 141
VAL A 222
LEU A 137
PHE A 172
THR A 171
 None
 1.24A 5bykA-5ejyA:
undetectable		 5bykA-5ejyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnm VITAMIN D(3)
25-HYDROXYLASE

(Pseudonocardia
autotrophica) 		PF00067
(p450) 		5 PRO A 282
LEU A 277
VAL A 242
LEU A 364
MET A 138
 HEM  A 501 ( 4.4A)
None
None
None
None
 1.14A 5bykA-5gnmA:
undetectable		 5bykA-5gnmA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdq FAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 PRO H 147
VAL H 150
THR H 108
MET H 177
THR H 165
 None
 1.16A 5bykA-5hdqH:
undetectable		 5bykA-5hdqH:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B

(Homo sapiens) 		no annotation 5 ILE A 793
LEU A 854
VAL A 833
LEU A 788
THR A 850
 None
 1.11A 5bykA-5hdtA:
undetectable		 5bykA-5hdtA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER

(Prochlorococcus
marinus) 		no annotation 5 ILE A 243
LEU A  19
VAL A   8
LEU A 233
PHE A 247
 None
 1.21A 5bykA-5lq8A:
undetectable		 5bykA-5lq8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Psychrobacter
arcticus) 		PF13393
(tRNA-synt_His) 		5 ILE A 143
VAL A 311
LEU A 152
THR A 318
MET A 309
 None
 1.17A 5bykA-5m8hA:
undetectable		 5bykA-5m8hA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc9 LAMININ SUBUNIT
ALPHA-1

(Mus musculus) 		PF00054
(Laminin_G_1)
PF06009
(Laminin_II) 		5 ILE A2466
LEU A2479
VAL A2326
LEU A2350
PHE A2318
 None
 1.31A 5bykA-5mc9A:
undetectable		 5bykA-5mc9A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me3 SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		5 LEU A1241
LEU A1344
PHE A1297
THR A1242
THR A1322
 None
 1.18A 5bykA-5me3A:
undetectable		 5bykA-5me3A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm7 -

(-) 		no annotation 5 ILE K 419
LEU K 437
VAL K 423
THR K 436
THR K 190
 None
 1.25A 5bykA-5mm7K:
undetectable		 5bykA-5mm7K:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my3 RHO
GTPASE-ACTIVATING
PROTEIN RGD1

(Saccharomyces
cerevisiae) 		no annotation 5 PRO A  38
ILE A  75
VAL A  41
LEU A  71
PHE A  22
 None
 1.28A 5bykA-5my3A:
undetectable		 5bykA-5my3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8o DNA HELICASE I

(Escherichia
coli) 		PF07057
(TraI)
PF08751
(TrwC)
PF13604
(AAA_30) 		5 ILE A 724
LEU A 634
VAL A 760
LEU A 727
MET A 745
 None
 1.27A 5bykA-5n8oA:
undetectable		 5bykA-5n8oA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5neu INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 MET A 559
ILE A 586
LEU A 497
VAL A 449
VAL A 475
 None
 1.07A 5bykA-5neuA:
undetectable		 5bykA-5neuA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns8 -

(-) 		no annotation 5 PRO A 115
ILE A 162
VAL A 215
PHE A 141
THR A 281
 None
 1.29A 5bykA-5ns8A:
undetectable		 5bykA-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5d GLUCANASE

(Trichoderma
atroviride) 		no annotation 5 ILE A 421
VAL A 290
VAL A 291
LEU A 362
THR A 429
 None
 1.22A 5bykA-5o5dA:
undetectable		 5bykA-5o5dA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiw SULFOTRANSFERASE

(Schistosoma
haematobium) 		no annotation 5 PRO A  31
HIS A  52
LEU A 101
VAL A 137
THR A 243
 OAQ  A 302 (-4.7A)
OAQ  A 302 ( 4.9A)
OAQ  A 302 ( 4.1A)
OAQ  A 302 (-4.0A)
None
 1.16A 5bykA-5tiwA:
39.8		 5bykA-5tiwA:
75.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiw SULFOTRANSFERASE

(Schistosoma
haematobium) 		no annotation 11 PRO A  31
HIS A  52
MET A  53
ILE A  57
LEU A 101
VAL A 136
VAL A 137
LEU A 156
PHE A 162
MET A 242
THR A 246
 OAQ  A 302 (-4.7A)
OAQ  A 302 ( 4.9A)
OAQ  A 302 (-4.5A)
OAQ  A 302 ( 4.9A)
OAQ  A 302 ( 4.1A)
None
OAQ  A 302 (-4.0A)
None
OAQ  A 302 (-4.6A)
OAQ  A 302 ( 4.0A)
OAQ  A 302 (-3.5A)
 0.37A 5bykA-5tiwA:
39.8		 5bykA-5tiwA:
75.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiz SULFOTRANSFERASE

(Schistosoma
japonicum) 		no annotation 5 HIS A  37
MET A  38
ILE A  42
VAL A 229
LEU A 143
 None
 1.21A 5bykA-5tizA:
35.3		 5bykA-5tizA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiz SULFOTRANSFERASE

(Schistosoma
japonicum) 		no annotation 6 PRO A  16
HIS A  37
LEU A  88
VAL A 123
VAL A 124
THR A 230
 None
 1.39A 5bykA-5tizA:
35.3		 5bykA-5tizA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tiz SULFOTRANSFERASE

(Schistosoma
japonicum) 		no annotation 10 PRO A  16
HIS A  37
MET A  38
ILE A  42
LEU A  88
VAL A 123
VAL A 124
LEU A 143
PHE A 149
THR A 233
 None
 0.57A 5bykA-5tizA:
35.3		 5bykA-5tizA:
57.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uja BOVINE MULTIDRUG
RESISTANCE PROTEIN 1
(MRP1),MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 ILE A 395
LEU A 317
VAL A 254
PHE A 321
THR A 320
 None
 1.30A 5bykA-5ujaA:
undetectable		 5bykA-5ujaA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujd SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNI

(Staphylococcus
pseudintermedius) 		no annotation 5 ILE A 183
VAL A 190
VAL A 189
MET A  55
THR A  49
 None
 1.01A 5bykA-5ujdA:
undetectable		 5bykA-5ujdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w40 POPP2 PROTEIN

(Ralstonia
solanacearum) 		PF03421
(Acetyltransf_14) 		5 PRO A 183
ILE A 323
VAL A 193
VAL A 190
LEU A 326
 None
 1.27A 5bykA-5w40A:
undetectable		 5bykA-5w40A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x59 S PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind) 		5 HIS A 670
ILE A 662
VAL A 659
VAL A 363
LEU A 735
 None
 1.07A 5bykA-5x59A:
undetectable		 5bykA-5x59A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn8 GLYCEROL
DEHYDROGENASE

(unidentified) 		PF00465
(Fe-ADH) 		5 PRO A   8
VAL A 113
VAL A 150
THR A 238
THR A  96
 None
 1.24A 5bykA-5xn8A:
undetectable		 5bykA-5xn8A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzu BETA-XYLANASE

(Bispora sp.
MEY-1) 		no annotation 5 ILE A 286
LEU A  14
VAL A 245
LEU A 250
MET A 235
 None
 1.20A 5bykA-5xzuA:
undetectable		 5bykA-5xzuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
SMALL SUBUNIT
ALDEHYDE OXIDASE
MEDIUM SUBUNIT

(Methylobacillus
sp. KY4400;
Methylobacillus
sp. KY4400) 		no annotation
no annotation 		5 LEU A  30
VAL A  60
VAL A  53
THR A  39
MET B 105
 None
 1.11A 5bykA-5y6qA:
undetectable		 5bykA-5y6qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq9 DNA TOPOISOMERASE 4
SUBUNIT A

(Pseudomonas
putida) 		no annotation 5 HIS A  40
ILE A 171
LEU A  38
LEU A 172
THR A 185
 None
None
None
None
CL  A 502 (-4.1A)
 1.16A 5bykA-6bq9A:
undetectable		 5bykA-6bq9A:
undetectable