SIMILAR PATTERNS OF AMINO ACIDS FOR 5BW4_B_SAMB301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aua PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
SEC14P

(Saccharomyces
cerevisiae) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		3 ASP A  54
GLU A  80
SER A 163
 None
 0.84A 5bw4B-1auaA:
undetectable		 5bw4B-1auaA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		3 ASP A 288
GLU A  71
SER A  93
 None
 0.86A 5bw4B-1crlA:
2.0		 5bw4B-1crlA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fep FERRIC ENTEROBACTIN
RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ASP A 232
GLU A 117
SER A  93
 None
 0.80A 5bw4B-1fepA:
undetectable		 5bw4B-1fepA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i6q LACTOFERRIN

(Camelus
dromedarius) 		PF00405
(Transferrin) 		3 ASP A 395
GLU A 354
SER A 676
 None
 0.81A 5bw4B-1i6qA:
undetectable		 5bw4B-1i6qA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ile ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		3 ASP A 546
GLU A 696
SER A 572
 None
 0.87A 5bw4B-1ileA:
undetectable		 5bw4B-1ileA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		3 ASP A 142
GLU A 131
SER A 172
 None
 0.86A 5bw4B-1jioA:
undetectable		 5bw4B-1jioA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1l SUPPRESSOR OF FUSED

(Homo sapiens) 		PF05076
(SUFU) 		3 ASP A 159
GLU A 181
SER A 151
 None
 0.75A 5bw4B-1m1lA:
undetectable		 5bw4B-1m1lA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mky PROBABLE GTP-BINDING
PROTEIN ENGA

(Thermotoga
maritima) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		3 ASP A  90
GLU A 125
SER A  15
 None
None
PO4  A 601 (-2.9A)
 0.86A 5bw4B-1mkyA:
undetectable		 5bw4B-1mkyA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 ASP A1297
GLU A 699
SER A 928
 None
 0.81A 5bw4B-1n5xA:
undetectable		 5bw4B-1n5xA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjm IMPORTIN ALPHA-2
SUBUNIT

(Mus musculus) 		PF00514
(Arm)
PF16186
(Arm_3) 		3 ASP B 280
GLU B 354
SER B 194
 None
 0.46A 5bw4B-1pjmB:
undetectable		 5bw4B-1pjmB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		3 ASP A  27
GLU A  32
SER A 119
 None
 0.79A 5bw4B-1qo8A:
2.3		 5bw4B-1qo8A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdq TENASCIN-R
AGGRECAN CORE
PROTEIN

(Rattus
norvegicus;
Rattus
norvegicus) 		PF00041
(fn3)
PF00059
(Lectin_C) 		3 ASP B 112
GLU B  82
SER A 129
 CA  B 127 (-2.9A)
None
None
 0.76A 5bw4B-1tdqB:
undetectable		 5bw4B-1tdqB:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA
OXYSTEROLS RECEPTOR
LXR-ALPHA

(Homo sapiens;
Homo sapiens) 		PF00104
(Hormone_recep)
PF00104
(Hormone_recep) 		3 ASP A 450
GLU A 378
SER B 303
 None
 0.85A 5bw4B-1uhlA:
undetectable		 5bw4B-1uhlA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		3 ASP A 247
GLU A 153
SER A 340
 None
 0.72A 5bw4B-1z45A:
5.4		 5bw4B-1z45A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		3 ASP A 465
GLU A 457
SER A 704
 None
 0.86A 5bw4B-1z8lA:
undetectable		 5bw4B-1z8lA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c8j FERROCHELATASE 1

(Bacillus
anthracis) 		PF00762
(Ferrochelatase) 		3 ASP A 236
GLU A 278
SER A 183
 None
 0.79A 5bw4B-2c8jA:
undetectable		 5bw4B-2c8jA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 ASP A  80
GLU A  85
SER A 101
 None
None
NAD  A1300 (-3.1A)
 0.75A 5bw4B-2eklA:
undetectable		 5bw4B-2eklA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		3 ASP A  72
GLU A 216
SER A 291
 None
 0.75A 5bw4B-2eyqA:
undetectable		 5bw4B-2eyqA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		3 ASP A 310
GLU A 254
SER A 382
 NA  A 997 (-3.2A)
None
PO4  A 900 ( 4.9A)
 0.83A 5bw4B-2f6dA:
undetectable		 5bw4B-2f6dA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY

(Rhodobacter
sphaeroides) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 277
GLU A 227
SER A  51
 None
NA  A1101 (-3.2A)
None
 0.82A 5bw4B-2hzgA:
2.3		 5bw4B-2hzgA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i79 ACETYLTRANSFERASE,
GNAT FAMILY

(Streptococcus
pneumoniae) 		PF00583
(Acetyltransf_1) 		3 ASP A  89
GLU A 147
SER A  56
 None
 0.80A 5bw4B-2i79A:
undetectable		 5bw4B-2i79A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iic ALPHA-11 GIARDIN

(Giardia
intestinalis) 		no annotation 3 ASP A 211
GLU A 168
SER A 238
 None
 0.80A 5bw4B-2iicA:
undetectable		 5bw4B-2iicA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 ASP X 101
GLU X 385
SER X 374
 None
 0.82A 5bw4B-2iv2X:
1.5		 5bw4B-2iv2X:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg5 FRUCTOSE 1-PHOSPHATE
KINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		3 ASP A 284
GLU A 100
SER A  74
 None
 0.84A 5bw4B-2jg5A:
2.6		 5bw4B-2jg5A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kpm UNCHARACTERIZED
PROTEIN

(Nitrosomonas
europaea) 		PF12872
(OST-HTH) 		3 ASP A  68
GLU A  16
SER A   5
 None
 0.80A 5bw4B-2kpmA:
undetectable		 5bw4B-2kpmA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana) 		PF12937
(F-box-like) 		3 ASP B 162
GLU B  72
SER B 271
 None
 0.86A 5bw4B-2p1nB:
undetectable		 5bw4B-2p1nB:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq6 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Rubrobacter
xylanophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 171
GLU A 266
SER A 147
 None
MG  A 409 (-2.4A)
None
 0.67A 5bw4B-2qq6A:
undetectable		 5bw4B-2qq6A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vou 2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE

(Paenarthrobacter
nicotinovorans) 		PF00070
(Pyr_redox) 		3 ASP A  99
GLU A 215
SER A  37
 None
 0.73A 5bw4B-2vouA:
3.7		 5bw4B-2vouA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqa SLL1358 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00190
(Cupin_1) 		3 ASP A 340
GLU A 114
SER A 247
 None
 0.85A 5bw4B-2vqaA:
undetectable		 5bw4B-2vqaA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Methanocaldococcus
jannaschii) 		PF00814
(Peptidase_M22)
PF01163
(RIO1) 		3 ASP A 451
GLU A 384
SER A 493
 None
 0.74A 5bw4B-2vwbA:
undetectable		 5bw4B-2vwbA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0f PUTATIVE
METAL-DEPENDENT
PHOSPHOESTERASE

(Bifidobacterium
adolescentis) 		PF02811
(PHP) 		3 ASP A  56
GLU A  63
SER A  99
 None
 0.86A 5bw4B-3e0fA:
undetectable		 5bw4B-3e0fA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6s PUTATIVE
ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
FAMILY PROTEIN

(Bacteroides
vulgatus) 		PF03372
(Exo_endo_phos) 		3 ASP A 172
GLU A  77
SER A 179
 None
 0.80A 5bw4B-3g6sA:
undetectable		 5bw4B-3g6sA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 ASP A 144
GLU A 168
SER A 306
 None
 0.86A 5bw4B-3h1lA:
undetectable		 5bw4B-3h1lA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2

(Gallus gallus;
Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 ASP B 114
GLU B  39
SER A 400
 None
 0.83A 5bw4B-3h1lB:
undetectable		 5bw4B-3h1lB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hka URONATE ISOMERASE

(Bacillus
halodurans) 		no annotation 3 ASP A 271
GLU A  44
SER A 223
 None
None
FIX  A 428 ( 4.1A)
 0.79A 5bw4B-3hkaA:
undetectable		 5bw4B-3hkaA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv6 PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		no annotation 3 ASP A 187
GLU A 203
SER A 163
 None
 0.75A 5bw4B-3iv6A:
0.8		 5bw4B-3iv6A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jur EXO-POLY-ALPHA-D-GAL
ACTURONOSIDASE

(Thermotoga
maritima) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		3 ASP A 260
GLU A 304
SER A 352
 None
 0.73A 5bw4B-3jurA:
undetectable		 5bw4B-3jurA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1h LYSINE SPECIFIC
CYSTEINE PROTEASE

(Porphyromonas
gingivalis) 		PF07675
(Cleaved_Adhesin) 		3 ASP A1596
GLU A1428
SER A1464
 CA  A2002 ( 4.7A)
None
None
 0.77A 5bw4B-3m1hA:
undetectable		 5bw4B-3m1hA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgz 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00926
(DHBP_synthase) 		3 ASP A  24
GLU A 146
SER A 168
 SO4  A 300 ( 4.9A)
SO4  A 300 ( 4.7A)
None
 0.83A 5bw4B-3mgzA:
undetectable		 5bw4B-3mgzA:
21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mq2 16S RRNA
METHYLTRANSFERASE

(Streptoalloteichus
tenebrarius) 		PF02390
(Methyltransf_4) 		3 ASP A  55
GLU A  88
SER A 192
 SAH  A 216 (-2.9A)
SAH  A 216 (-2.9A)
SAH  A 216 (-3.3A)
 0.76A 5bw4B-3mq2A:
27.2		 5bw4B-3mq2A:
35.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Kosmotoga
olearia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 337
GLU A 261
SER A 173
 None
MG  A 400 ( 4.0A)
None
 0.74A 5bw4B-3mwcA:
undetectable		 5bw4B-3mwcA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6x GLUTAMINE SYNTHETASE

(Bacteroides
fragilis) 		PF00120
(Gln-synt_C)
PF12437
(GSIII_N) 		3 ASP A  37
GLU A 299
SER A  81
 None
 0.82A 5bw4B-3o6xA:
undetectable		 5bw4B-3o6xA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1

(Homo sapiens) 		PF00621
(RhoGEF) 		3 ASP A 440
GLU A 448
SER A 472
 None
 0.86A 5bw4B-3odwA:
undetectable		 5bw4B-3odwA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		3 ASP A  88
GLU A 150
SER A  44
 None
 0.77A 5bw4B-3pkoA:
undetectable		 5bw4B-3pkoA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4i PHOSPHOHYDROLASE
(MUTT/NUDIX FAMILY
PROTEIN)

(Bacillus cereus) 		PF00293
(NUDIX)
PF12535
(Nudix_N) 		3 ASP A  70
GLU A 116
SER A 140
 None
GD3  A 301 (-3.1A)
None
 0.86A 5bw4B-3q4iA:
undetectable		 5bw4B-3q4iA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqw PUTATIVE CITRATE
LYASE

(Cupriavidus
pinatubonensis) 		PF03328
(HpcH_HpaI) 		3 ASP A  90
GLU A 127
SER A 181
 None
 0.71A 5bw4B-3qqwA:
undetectable		 5bw4B-3qqwA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swj PUTATIVE
UNCHARACTERIZED
PROTEIN

(Campylobacter
jejuni) 		PF01243
(Putative_PNPOx)
PF10615
(DUF2470) 		3 ASP A 229
GLU A 148
SER A 241
 None
 0.82A 5bw4B-3swjA:
undetectable		 5bw4B-3swjA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 258
GLU A 209
SER A  36
 None
MG  A 371 ( 2.9A)
None
 0.67A 5bw4B-3u4fA:
undetectable		 5bw4B-3u4fA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfo POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		3 ASP A  58
GLU A 195
SER A 114
 None
SO4  A 601 ( 4.4A)
None
 0.69A 5bw4B-3wfoA:
undetectable		 5bw4B-3wfoA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfp POLY A POLYMERASE

(synthetic
construct;
Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		3 ASP A  58
GLU A 195
SER A 114
 SO4  A1001 ( 4.7A)
None
None
 0.71A 5bw4B-3wfpA:
undetectable		 5bw4B-3wfpA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy2 ALPHA-GLUCOSIDASE

(Halomonas sp.
H11) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		3 ASP A 387
GLU A 377
SER A 145
 None
 0.79A 5bw4B-3wy2A:
undetectable		 5bw4B-3wy2A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE

(Methanothermobacter
thermautotrophicus) 		PF02374
(ArsA_ATPase) 		3 ASP A 163
GLU A 204
SER A 218
 None
 0.67A 5bw4B-3zq6A:
undetectable		 5bw4B-3zq6A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccl 50S RIBOSOMAL
PROTEIN L16 ARGININE
HYDROXYLASE

(Escherichia
coli) 		PF08007
(Cupin_4) 		3 ASP A 326
GLU A 262
SER A 366
 None
 0.84A 5bw4B-4cclA:
undetectable		 5bw4B-4cclA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgt CYCLODEXTRIN
GLYCOSYLTRANSFERASE

(Bacillus
circulans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		3 ASP A 371
GLU A 257
SER A  90
 None
 0.86A 5bw4B-4cgtA:
undetectable		 5bw4B-4cgtA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d51 CYMA

(Klebsiella
oxytoca) 		PF16941
(CymA) 		3 ASP A   3
GLU A 224
SER A 162
 None
 0.85A 5bw4B-4d51A:
undetectable		 5bw4B-4d51A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecg PUTATIVE
IRON-REGULATED
PROTEIN A

(Parabacteroides
distasonis) 		PF09375
(Peptidase_M75) 		3 ASP A 131
GLU A 158
SER A 303
 CA  A 504 (-3.3A)
None
None
 0.71A 5bw4B-4ecgA:
undetectable		 5bw4B-4ecgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		3 ASP B  87
GLU B  19
SER B 527
 None
 0.86A 5bw4B-4fhnB:
undetectable		 5bw4B-4fhnB:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3b M1 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		3 ASP A 581
GLU A1041
SER A 530
 None
 0.87A 5bw4B-4j3bA:
undetectable		 5bw4B-4j3bA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		3 ASP A 372
GLU A 258
SER A  90
 GOL  A 716 (-2.7A)
None
EDO  A 727 ( 4.8A)
 0.83A 5bw4B-4jclA:
undetectable		 5bw4B-4jclA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2n ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE

(Magnetospirillum
magneticum) 		PF00378
(ECH_1) 		3 ASP A 190
GLU A  10
SER A 128
 None
 0.78A 5bw4B-4k2nA:
undetectable		 5bw4B-4k2nA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrj EFFECTOR NLEH1

(Escherichia
coli) 		no annotation 3 ASP A 239
GLU A 169
SER A 208
 None
 0.76A 5bw4B-4lrjA:
undetectable		 5bw4B-4lrjA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mc5 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 ASP A  98
GLU A 103
SER A 219
 None
 0.86A 5bw4B-4mc5A:
undetectable		 5bw4B-4mc5A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe6 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00171
(Aldedh) 		3 ASP A 142
GLU A 252
SER A  57
 None
 0.81A 5bw4B-4oe6A:
3.4		 5bw4B-4oe6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		3 ASP A 414
GLU A 382
SER A  39
 None
 0.82A 5bw4B-4pfyA:
undetectable		 5bw4B-4pfyA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE

(Escherichia
coli) 		PF08003
(Methyltransf_9) 		3 ASP A 152
GLU A 182
SER A 107
 None
SO4  A 404 (-4.7A)
None
 0.86A 5bw4B-4qnxA:
11.3		 5bw4B-4qnxA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB

(Lactococcus
lactis) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		3 ASP A 349
GLU A 544
SER A 836
 None
 0.82A 5bw4B-4wd9A:
undetectable		 5bw4B-4wd9A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wn9 NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		3 ASP A 125
GLU A 164
SER A 113
 None
 0.69A 5bw4B-4wn9A:
undetectable		 5bw4B-4wn9A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		no annotation 3 ASP E 396
GLU E 447
SER E 529
 None
 0.71A 5bw4B-4xmmE:
undetectable		 5bw4B-4xmmE:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 ASP A 499
GLU A 494
SER A 521
 None
 0.84A 5bw4B-4ztxA:
undetectable		 5bw4B-4ztxA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dhx ANTI-REV ANTIBODY
FAB SINGLE-CHAIN
VARIABLE FRAGMENT,
LIGHT CHAIN,ANTI-REV
ANTIBODY FAB
SINGLE-CHAIN
VARIABLE FRAGMENT,
HEAVY CHAIN

(Oryctolagus
cuniculus) 		PF07686
(V-set) 		3 ASP B 207
GLU B 112
SER B  31
 None
 0.85A 5bw4B-5dhxB:
undetectable		 5bw4B-5dhxB:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		3 ASP A 864
GLU A 894
SER A 407
 None
 0.83A 5bw4B-5dkxA:
undetectable		 5bw4B-5dkxA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 3 ASP B 476
GLU B 468
SER B 349
 None
 0.86A 5bw4B-5dlqB:
undetectable		 5bw4B-5dlqB:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy3 GLUCANASE

(Klebsiella
pneumoniae) 		PF01270
(Glyco_hydro_8) 		3 ASP A 217
GLU A  53
SER A 212
 None
 0.73A 5bw4B-5gy3A:
undetectable		 5bw4B-5gy3A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h68 CHROMOSOME PARTITION
PROTEIN SMC

(Geobacillus
stearothermophilus) 		PF02463
(SMC_N) 		3 ASP A  42
GLU A 136
SER A1171
 None
 0.80A 5bw4B-5h68A:
undetectable		 5bw4B-5h68A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8) 		3 ASP A 113
GLU A 329
SER A 450
 NAG  A 801 ( 3.4A)
None
None
 0.82A 5bw4B-5hzwA:
undetectable		 5bw4B-5hzwA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2g DIOL DEHYDRATASE

(Roseburia
inulinivorans) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 ASP A 362
GLU A 310
SER A 390
 None
 0.70A 5bw4B-5i2gA:
undetectable		 5bw4B-5i2gA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1

(Burkholderia
thailandensis) 		PF05853
(BKACE) 		3 ASP A 163
GLU A  53
SER A 125
 None
 0.57A 5bw4B-5ikzA:
undetectable		 5bw4B-5ikzA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq0 ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		3 ASP A  86
GLU A  80
SER A 114
 None
 0.75A 5bw4B-5iq0A:
undetectable		 5bw4B-5iq0A:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3u PROTEIN KINASE A

(Toxoplasma
gondii) 		PF00027
(cNMP_binding) 		3 ASP A 230
GLU A 383
SER A 251
 None
 0.85A 5bw4B-5j3uA:
undetectable		 5bw4B-5j3uA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
SYNTHASE COMPONENT F

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		3 ASP A 840
GLU A 750
SER A 772
 75C  A1301 (-3.0A)
None
None
 0.81A 5bw4B-5ja1A:
undetectable		 5bw4B-5ja1A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd4 LAE6

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		3 ASP A  37
GLU A 124
SER A 290
 None
 0.82A 5bw4B-5jd4A:
undetectable		 5bw4B-5jd4A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jja SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF01603
(B56) 		3 ASP A 278
GLU A 241
SER A 318
 ASP  A 278 ( 0.6A)
GLU  A 241 ( 0.6A)
SER  A 318 ( 0.0A)
 0.64A 5bw4B-5jjaA:
undetectable		 5bw4B-5jjaA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		3 ASP A 384
GLU A 377
SER A 664
 None
 0.81A 5bw4B-5kf7A:
3.9		 5bw4B-5kf7A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq4 CYAGOX

(Cyanothece sp.
PCC 7425) 		PF00881
(Nitroreductase) 		3 ASP A   3
GLU A  78
SER A 110
 None
 0.84A 5bw4B-5lq4A:
undetectable		 5bw4B-5lq4A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea) 		no annotation 3 ASP A 440
GLU A 519
SER A 451
 None
 0.86A 5bw4B-5m6gA:
2.6		 5bw4B-5m6gA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 3 ASP A 159
GLU A 123
SER A 688
 None
 0.82A 5bw4B-5necA:
undetectable		 5bw4B-5necA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 3 ASP A 213
GLU A 218
SER A 353
 None
 0.83A 5bw4B-5nqdA:
2.1		 5bw4B-5nqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6u UNCHARACTERIZED
PROTEIN

(Shewanella
putrefaciens) 		no annotation 3 ASP C 188
GLU C 240
SER C 124
 None
 0.72A 5bw4B-5o6uC:
undetectable		 5bw4B-5o6uC:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9w THEBAINE
6-O-DEMETHYLASE

(Papaver
somniferum) 		no annotation 3 ASP A 144
GLU A 137
SER A 307
 None
None
AKG  A 402 (-2.5A)
 0.82A 5bw4B-5o9wA:
undetectable		 5bw4B-5o9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ted LMO0488 PROTEIN

(Listeria
monocytogenes) 		no annotation 3 ASP B 286
GLU B 158
SER B  89
 None
 0.80A 5bw4B-5tedB:
undetectable		 5bw4B-5tedB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM6
CELL DIVISION CYCLE
PROTEIN CDT1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB)
PF16679
(CDT1_C) 		3 ASP 6 154
GLU 6 131
SER 8 522
 None
 0.65A 5bw4B-5udb6:
undetectable		 5bw4B-5udb6:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni VESICLE-TRAFFICKING
PROTEIN SEC22B

(Mus musculus) 		PF13774
(Longin) 		3 ASP C  12
GLU C  46
SER C 111
 None
 0.76A 5bw4B-5vniC:
undetectable		 5bw4B-5vniC:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C)
PF01801
(Cytomega_gL) 		3 ASP B 129
GLU B  94
SER A  68
 None
 0.71A 5bw4B-5vocB:
undetectable		 5bw4B-5vocB:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw3 O-ACETYLSERINE LYASE

(Bacillus
anthracis) 		PF00291
(PALP) 		3 ASP A  45
GLU A  69
SER A 293
 None
 0.84A 5bw4B-5xw3A:
undetectable		 5bw4B-5xw3A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E
PHASE 2
FLAGELLIN,FLAGELLIN

(Mus musculus;
Salmonella
enterica) 		no annotation
no annotation 		3 ASP C 436
GLU A 987
SER A 852
 None
 0.74A 5bw4B-5yudC:
undetectable		 5bw4B-5yudC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avw CARBOXYLESTERASE
SOBER1

(Arabidopsis
thaliana) 		no annotation 3 ASP A 160
GLU A 198
SER A  69
 None
 0.64A 5bw4B-6avwA:
2.7		 5bw4B-6avwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bf6 INSULIN-DEGRADING
ENZYME

(Homo sapiens) 		no annotation 3 ASP A 935
GLU A 879
SER A 801
 None
 0.82A 5bw4B-6bf6A:
undetectable		 5bw4B-6bf6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT
POLYMERASE BASIC
PROTEIN 2

(Influenza B
virus;
Influenza B
virus) 		no annotation
no annotation 		3 ASP C  85
GLU B 685
SER C  55
 None
 0.76A 5bw4B-6f5oC:
undetectable		 5bw4B-6f5oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fju -

(-) 		no annotation 3 ASP A 168
GLU A  68
SER A  19
 None
 0.80A 5bw4B-6fjuA:
undetectable		 5bw4B-6fjuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger) 		no annotation 3 ASP A 287
GLU A 366
SER A 460
 None
 0.78A 5bw4B-6frvA:
undetectable		 5bw4B-6frvA:
undetectable