SIMILAR PATTERNS OF AMINO ACIDS FOR 5BS8_G_MFXG101_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b9h | PROTEIN(3-AMINO-5-HYDROXYBENZOIC ACID SYNTHASE) (Amycolatopsismediterranei) |
PF01041(DegT_DnrJ_EryC1) | 4 | ALA A 58ARG A 172GLY A 174GLU A 175 | None | 0.87A | 5bs8A-1b9hA:1.05bs8C-1b9hA:1.15bs8D-1b9hA:0.2 | 5bs8A-1b9hA:22.315bs8C-1b9hA:22.315bs8D-1b9hA:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bqg | D-GLUCARATEDEHYDRATASE (Pseudomonasputida) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ALA A 96ARG A 68GLY A 66GLU A 65 | None | 0.68A | 5bs8A-1bqgA:0.05bs8C-1bqgA:0.05bs8D-1bqgA:0.9 | 5bs8A-1bqgA:23.275bs8C-1bqgA:23.275bs8D-1bqgA:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c7t | BETA-N-ACETYLHEXOSAMINIDASE (Serratiamarcescens) |
PF00728(Glyco_hydro_20)PF02838(Glyco_hydro_20b)PF03173(CHB_HEX)PF03174(CHB_HEX_C) | 4 | ASP A 346ARG A 349GLY A 381GLU A 380 | NoneCBS A1001 (-3.0A)NoneNone | 0.80A | 5bs8A-1c7tA:0.05bs8C-1c7tA:0.05bs8D-1c7tA:undetectable | 5bs8A-1c7tA:21.295bs8C-1c7tA:21.295bs8D-1c7tA:15.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f4h | BETA-GALACTOSIDASE (Escherichiacoli) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N)PF16353(DUF4981) | 4 | ALA A 97ASP A 598THR A 799GLU A 797 | None | 0.91A | 5bs8A-1f4hA:0.05bs8C-1f4hA:0.05bs8D-1f4hA:undetectable | 5bs8A-1f4hA:19.175bs8C-1f4hA:19.175bs8D-1f4hA:13.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gey | HISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Escherichiacoli) |
PF00155(Aminotran_1_2) | 4 | ALA A 36ARG A 82GLY A 83GLU A 86 | PPE A 413 (-3.7A)NonePPE A 413 (-3.4A)None | 0.78A | 5bs8A-1geyA:1.35bs8C-1geyA:1.35bs8D-1geyA:1.0 | 5bs8A-1geyA:24.365bs8C-1geyA:24.365bs8D-1geyA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1it5 | PHOSPHOLIPASE A2 (Streptomycesviolaceoruber) |
PF09056(Phospholip_A2_3) | 4 | ALA A 26ASP A 39ARG A 69GLY A 67 | None | 0.89A | 5bs8A-1it5A:0.05bs8C-1it5A:0.05bs8D-1it5A:undetectable | 5bs8A-1it5A:12.335bs8C-1it5A:12.335bs8D-1it5A:17.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k7y | METHIONINE SYNTHASE (Escherichiacoli) |
PF02310(B12-binding)PF02607(B12-binding_2)PF02965(Met_synt_B12) | 4 | ALA A 909ASP A1010THR A1146GLU A1147 | None | 0.78A | 5bs8A-1k7yA:0.05bs8C-1k7yA:0.05bs8D-1k7yA:4.7 | 5bs8A-1k7yA:24.135bs8C-1k7yA:24.135bs8D-1k7yA:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1msk | COBALAMIN-DEPENDENTMETHIONINE SYNTHASE (Escherichiacoli) |
PF02965(Met_synt_B12) | 4 | ALA A 909ASP A1010THR A1146GLU A1147 | None | 0.91A | 5bs8A-1mskA:0.05bs8C-1mskA:undetectable5bs8D-1mskA:undetectable | 5bs8A-1mskA:21.105bs8C-1mskA:21.105bs8D-1mskA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nne | DNA MISMATCH REPAIRPROTEIN MUTS (Thermusaquaticus) |
PF00488(MutS_V)PF01624(MutS_I)PF05188(MutS_II)PF05190(MutS_IV)PF05192(MutS_III) | 4 | ALA A 531ARG A 363GLY A 367GLU A 368 | None | 0.91A | 5bs8A-1nneA:undetectable5bs8C-1nneA:undetectable5bs8D-1nneA:undetectable | 5bs8A-1nneA:21.955bs8C-1nneA:21.955bs8D-1nneA:17.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ocm | MALONAMIDASE E2 (Bradyrhizobiumjaponicum) |
PF01425(Amidase) | 4 | ALA A 137ASP A 63ARG A 41GLY A 103 | None | 0.91A | 5bs8A-1ocmA:undetectable5bs8C-1ocmA:undetectable5bs8D-1ocmA:undetectable | 5bs8A-1ocmA:24.805bs8C-1ocmA:24.805bs8D-1ocmA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pjq | SIROHEME SYNTHASE (Salmonellaenterica) |
PF00590(TP_methylase)PF10414(CysG_dimeriser)PF13241(NAD_binding_7)PF14824(Sirohm_synth_M) | 4 | ALA A 332ARG A 309GLY A 310GLU A 312 | ACT A 505 (-3.0A)NoneNoneNone | 0.86A | 5bs8A-1pjqA:undetectable5bs8C-1pjqA:undetectable5bs8D-1pjqA:undetectable | 5bs8A-1pjqA:21.965bs8C-1pjqA:21.965bs8D-1pjqA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5a | EP-CADHERIN (Mus musculus) |
PF00028(Cadherin) | 4 | ALA A 285ARG A 241GLY A 280GLU A 276 | None | 0.00A | 5bs8A-1q5aA:undetectable5bs8C-1q5aA:undetectable5bs8D-1q5aA:undetectable | 5bs8A-1q5aA:22.215bs8C-1q5aA:22.215bs8D-1q5aA:14.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s6i | CALCIUM-DEPENDENTPROTEIN KINASE SK5 (Glycine max) |
PF13499(EF-hand_7) | 4 | ALA A 165ASP A 92GLY A 136GLU A 137 | NoneNoneNone CA A 192 (-2.5A) | 0.77A | 5bs8A-1s6iA:undetectable5bs8C-1s6iA:undetectable5bs8D-1s6iA:undetectable | 5bs8A-1s6iA:15.195bs8C-1s6iA:15.195bs8D-1s6iA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sj8 | TALIN 1 (Mus musculus) |
PF09141(Talin_middle) | 4 | ALA A 770ARG A 741GLY A 740GLU A 738 | None | 0.84A | 5bs8A-1sj8A:undetectable5bs8C-1sj8A:undetectable5bs8D-1sj8A:undetectable | 5bs8A-1sj8A:20.125bs8C-1sj8A:20.125bs8D-1sj8A:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sxd | GA REPEAT BINDINGPROTEIN, ALPHA (Mus musculus) |
PF02198(SAM_PNT) | 4 | ALA A 253ARG A 220GLY A 219GLU A 221 | None | 0.82A | 5bs8A-1sxdA:undetectable5bs8C-1sxdA:undetectable5bs8D-1sxdA:undetectable | 5bs8A-1sxdA:9.725bs8C-1sxdA:9.725bs8D-1sxdA:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tdk | L-AMINO ACID OXIDASE (Gloydius halys) |
PF01593(Amino_oxidase) | 4 | ALA A 49ARG A 67GLY A 70THR A 74 | NoneNoneFAD A 488 (-2.8A)None | 0.91A | 5bs8A-1tdkA:undetectable5bs8C-1tdkA:undetectable5bs8D-1tdkA:undetectable | 5bs8A-1tdkA:23.455bs8C-1tdkA:23.455bs8D-1tdkA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vdc | NADPH DEPENDENTTHIOREDOXINREDUCTASE (Arabidopsisthaliana) |
PF07992(Pyr_redox_2) | 4 | ARG A 69GLY A 40THR A 81GLU A 35 | None | 0.67A | 5bs8A-1vdcA:undetectable5bs8C-1vdcA:undetectable5bs8D-1vdcA:undetectable | 5bs8A-1vdcA:20.905bs8C-1vdcA:20.905bs8D-1vdcA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wn1 | DIPEPTIDASE (Pyrococcushorikoshii) |
PF00557(Peptidase_M24)PF01321(Creatinase_N) | 4 | ALA A 168ASP A 210ARG A 207GLY A 161 | None | 0.83A | 5bs8A-1wn1A:undetectable5bs8C-1wn1A:undetectable5bs8D-1wn1A:undetectable | 5bs8A-1wn1A:24.715bs8C-1wn1A:24.715bs8D-1wn1A:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x87 | UROCANASE PROTEIN (Geobacillusstearothermophilus) |
PF01175(Urocanase)PF17391(Urocanase_N)PF17392(Urocanase_C) | 4 | ALA A 536ASP A 520ARG A 437GLY A 354 | None | 0.89A | 5bs8A-1x87A:1.65bs8C-1x87A:1.55bs8D-1x87A:undetectable | 5bs8A-1x87A:21.805bs8C-1x87A:21.805bs8D-1x87A:17.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xrc | S-ADENOSYLMETHIONINESYNTHETASE (Escherichiacoli) |
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C) | 4 | ALA A 60GLY A 54THR A 242GLU A 42 | NoneNone K A 413 ( 4.7A) K A 413 (-2.9A) | 0.92A | 5bs8A-1xrcA:1.35bs8C-1xrcA:1.35bs8D-1xrcA:undetectable | 5bs8A-1xrcA:21.255bs8C-1xrcA:21.255bs8D-1xrcA:24.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xv5 | DNAALPHA-GLUCOSYLTRANSFERASE (Escherichiavirus T4) |
PF11440(AGT) | 4 | ALA A1062ARG A1009GLY A1010GLU A1012 | NoneNoneNoneCME A1014 (-3.8A) | 0.85A | 5bs8A-1xv5A:undetectable5bs8C-1xv5A:undetectable5bs8D-1xv5A:undetectable | 5bs8A-1xv5A:21.615bs8C-1xv5A:21.615bs8D-1xv5A:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y0e | PUTATIVEN-ACETYLMANNOSAMINE-6-PHOSPHATE2-EPIMERASE (Staphylococcusaureus) |
PF04131(NanE) | 4 | ARG A 40GLY A 203THR A 145GLU A 180 | NonePO4 A 502 (-3.6A)NoneNone | 0.92A | 5bs8A-1y0eA:undetectable5bs8C-1y0eA:undetectable5bs8D-1y0eA:undetectable | 5bs8A-1y0eA:16.705bs8C-1y0eA:16.705bs8D-1y0eA:25.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yvp | 60-KDA SS-A/RORIBONUCLEOPROTEIN (Xenopus laevis) |
PF05731(TROVE) | 4 | ASP A 523ARG A 85GLY A 84GLU A 83 | NoneNone C G 8 ( 4.5A)None | 0.87A | 5bs8A-1yvpA:undetectable5bs8C-1yvpA:undetectable5bs8D-1yvpA:2.3 | 5bs8A-1yvpA:22.435bs8C-1yvpA:22.435bs8D-1yvpA:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zwx | SPHINGOMYELINASE-C (Listeriaivanovii) |
PF03372(Exo_endo_phos) | 4 | ALA A 73ASP A 91ARG A 57GLY A 64 | None | 0.79A | 5bs8A-1zwxA:undetectable5bs8C-1zwxA:undetectable5bs8D-1zwxA:undetectable | 5bs8A-1zwxA:18.545bs8C-1zwxA:18.545bs8D-1zwxA:18.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aaa | ALPHA-AMYLASE (Aspergillusniger) |
PF00128(Alpha-amylase)PF09260(DUF1966) | 4 | ALA A 182ASP A 214THR A 159GLU A 162 | None | 0.80A | 5bs8A-2aaaA:undetectable5bs8C-2aaaA:undetectable5bs8D-2aaaA:undetectable | 5bs8A-2aaaA:22.855bs8C-2aaaA:22.855bs8D-2aaaA:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2atv | RAS-LIKEESTROGEN-REGULATEDGROWTH INHIBITOR (Homo sapiens) |
PF00071(Ras) | 4 | ALA A 149ARG A 14GLY A 13GLU A 94 | GDP A 415 (-3.7A)NoneNoneNone | 0.88A | 5bs8A-2atvA:undetectable5bs8C-2atvA:undetectable5bs8D-2atvA:3.7 | 5bs8A-2atvA:17.435bs8C-2atvA:17.435bs8D-2atvA:24.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fkn | UROCANATE HYDRATASE (Bacillussubtilis) |
PF01175(Urocanase)PF17391(Urocanase_N)PF17392(Urocanase_C) | 4 | ALA A 537ASP A 521ARG A 438GLY A 355 | None | 0.76A | 5bs8A-2fknA:1.35bs8C-2fknA:undetectable5bs8D-2fknA:undetectable | 5bs8A-2fknA:22.415bs8C-2fknA:22.415bs8D-2fknA:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fvg | ENDOGLUCANASE (Thermotogamaritima) |
PF05343(Peptidase_M42) | 4 | ALA A 243ASP A 166GLY A 170THR A 193 | NoneNoneNoneEDO A 342 ( 4.0A) | 0.88A | 5bs8A-2fvgA:undetectable5bs8C-2fvgA:undetectable5bs8D-2fvgA:2.2 | 5bs8A-2fvgA:22.295bs8C-2fvgA:22.295bs8D-2fvgA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fwv | HYPOTHETICAL PROTEINMTUBF_01000852 (Mycobacteriumtuberculosis) |
PF08768(DUF1794) | 4 | ARG A 82ARG A 89GLY A 79GLU A 78 | None | 0.86A | 5bs8A-2fwvA:undetectable5bs8C-2fwvA:undetectable5bs8D-2fwvA:undetectable | 5bs8A-2fwvA:19.285bs8C-2fwvA:19.285bs8D-2fwvA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2glx | 1,5-ANHYDRO-D-FRUCTOSE REDUCTASE (Ensiferadhaerens) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 4 | ALA A 286ARG A 22GLY A 26GLU A 27 | None | 0.76A | 5bs8A-2glxA:undetectable5bs8C-2glxA:undetectable5bs8D-2glxA:1.8 | 5bs8A-2glxA:24.045bs8C-2glxA:24.045bs8D-2glxA:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2htm | PUTATIVE THIAMINEBIOSYNTHESIS PROTEINTHISTHIAZOLEBIOSYNTHESIS PROTEINTHIG (Thermusthermophilus) |
PF02597(ThiS)PF05690(ThiG) | 5 | ALA A 37ASP A 184GLY E 64THR A 70GLU A 98 | None | 1.48A | 5bs8A-2htmA:undetectable5bs8C-2htmA:undetectable5bs8D-2htmA:undetectable | 5bs8A-2htmA:21.015bs8C-2htmA:21.015bs8D-2htmA:25.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i1y | RECEPTOR-TYPETYROSINE-PROTEINPHOSPHATASE (Homo sapiens) |
PF00102(Y_phosphatase) | 4 | ALA A 729ASP A 911ARG A 954GLY A 951 | None | 0.91A | 5bs8A-2i1yA:undetectable5bs8C-2i1yA:undetectable5bs8D-2i1yA:2.4 | 5bs8A-2i1yA:21.975bs8C-2i1yA:21.975bs8D-2i1yA:24.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2isn | NYSGXRC-8828Z,PHOSPHATASE (Toxoplasmagondii) |
PF00481(PP2C) | 4 | ALA A 185ARG A 235THR A 207GLU A 208 | None | 0.72A | 5bs8A-2isnA:undetectable5bs8C-2isnA:undetectable5bs8D-2isnA:undetectable | 5bs8A-2isnA:21.975bs8C-2isnA:21.975bs8D-2isnA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o2k | METHIONINE SYNTHASE (Homo sapiens) |
PF02965(Met_synt_B12) | 4 | ALA A 935ASP A1043THR A1184GLU A1185 | None | 0.89A | 5bs8A-2o2kA:undetectable5bs8C-2o2kA:undetectable5bs8D-2o2kA:undetectable | 5bs8A-2o2kA:21.265bs8C-2o2kA:21.265bs8D-2o2kA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o78 | PUTATIVE HISTIDINEAMMONIA-LYASE (Rhodobactersphaeroides) |
PF00221(Lyase_aromatic) | 4 | ALA A 103ARG A 185GLY A 182GLU A 181 | None | 0.89A | 5bs8A-2o78A:undetectable5bs8C-2o78A:undetectable5bs8D-2o78A:undetectable | 5bs8A-2o78A:26.075bs8C-2o78A:26.075bs8D-2o78A:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oxt | NUCLEOSIDE-2'-O-METHYLTRANSFERASE (Meaban virus) |
PF01728(FtsJ) | 4 | ALA A 92ARG A 85GLY A 84GLU A 112 | NoneNoneSAM A 300 (-3.5A)None | 0.90A | 5bs8A-2oxtA:undetectable5bs8C-2oxtA:undetectable5bs8D-2oxtA:undetectable | 5bs8A-2oxtA:20.285bs8C-2oxtA:20.285bs8D-2oxtA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oxt | NUCLEOSIDE-2'-O-METHYLTRANSFERASE (Meaban virus) |
PF01728(FtsJ) | 4 | ALA A 93ARG A 85GLY A 84GLU A 112 | NoneNoneSAM A 300 (-3.5A)None | 0.86A | 5bs8A-2oxtA:undetectable5bs8C-2oxtA:undetectable5bs8D-2oxtA:undetectable | 5bs8A-2oxtA:20.285bs8C-2oxtA:20.285bs8D-2oxtA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pq6 | UDP-GLUCURONOSYL/UDP-GLUCOSYLTRANSFERASE (Medicagotruncatula) |
PF00201(UDPGT) | 4 | ARG A 96ASP A 221ARG A 160GLU A 164 | None | 0.89A | 5bs8A-2pq6A:undetectable5bs8C-2pq6A:undetectable5bs8D-2pq6A:undetectable | 5bs8A-2pq6A:21.405bs8C-2pq6A:21.405bs8D-2pq6A:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r9q | 2'-DEOXYCYTIDINE5'-TRIPHOSPHATEDEAMINASE (Agrobacteriumfabrum) |
PF06559(DCD) | 4 | ALA A 21ARG A 170GLY A 12GLU A 339 | None | 0.88A | 5bs8A-2r9qA:undetectable5bs8C-2r9qA:undetectable5bs8D-2r9qA:undetectable | 5bs8A-2r9qA:21.485bs8C-2r9qA:21.485bs8D-2r9qA:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v7g | UROCANATE HYDRATASE (Pseudomonasputida) |
PF01175(Urocanase)PF17391(Urocanase_N)PF17392(Urocanase_C) | 4 | ALA A 541ASP A 525ARG A 442GLY A 359 | None | 0.80A | 5bs8A-2v7gA:undetectable5bs8C-2v7gA:undetectable5bs8D-2v7gA:undetectable | 5bs8A-2v7gA:22.445bs8C-2v7gA:22.445bs8D-2v7gA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2woc | ADP-RIBOSYL-[DINITROGEN REDUCTASE]GLYCOHYDROLASE (Rhodospirillumrubrum) |
PF03747(ADP_ribosyl_GH) | 4 | ALA A 255ASP A 61GLY A 24GLU A 28 | NoneFMT A 402 ( 4.1A)None MN A 401 (-3.1A) | 0.91A | 5bs8A-2wocA:undetectable5bs8C-2wocA:undetectable5bs8D-2wocA:undetectable | 5bs8A-2wocA:21.335bs8C-2wocA:21.335bs8D-2wocA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wu8 | GLUCOSE-6-PHOSPHATEISOMERASE (Mycobacteriumtuberculosis) |
PF00342(PGI) | 4 | ALA A 170ASP A 276ARG A 104GLY A 298 | None | 0.80A | 5bs8A-2wu8A:undetectable5bs8C-2wu8A:undetectable5bs8D-2wu8A:3.1 | 5bs8A-2wu8A:24.225bs8C-2wu8A:24.225bs8D-2wu8A:19.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2xkk | TOPOISOMERASE IV (Acinetobacterbaumannii) |
PF00521(DNA_topoisoIV)PF00986(DNA_gyraseB_C)PF01751(Toprim) | 4 | ASP A 397ARG A 418GLY A 419GLU A 437 | None | 0.71A | 5bs8A-2xkkA:48.25bs8C-2xkkA:48.25bs8D-2xkkA:26.5 | 5bs8A-2xkkA:30.595bs8C-2xkkA:30.595bs8D-2xkkA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yij | PHOSPHOLIPASEA1-IIGAMMA (Arabidopsisthaliana) |
PF01764(Lipase_3) | 4 | ARG A 218GLY A 217THR A 98GLU A 215 | None | 0.80A | 5bs8A-2yijA:undetectable5bs8C-2yijA:undetectable5bs8D-2yijA:undetectable | 5bs8A-2yijA:22.205bs8C-2yijA:22.205bs8D-2yijA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxg | DIHYDRODIPICOLINATESYNTHASE (Methanocaldococcusjannaschii) |
PF00701(DHDPS) | 4 | ALA A 84ARG A 115GLY A 113GLU A 112 | None | 0.91A | 5bs8A-2yxgA:undetectable5bs8C-2yxgA:undetectable5bs8D-2yxgA:undetectable | 5bs8A-2yxgA:22.175bs8C-2yxgA:22.175bs8D-2yxgA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yzw | ADP-RIBOSYLGLYCOHYDROLASE (Thermusthermophilus) |
PF03747(ADP_ribosyl_GH) | 4 | ALA A 263ASP A 58GLY A 25GLU A 29 | NoneGD3 A 502 (-3.1A)NoneGD3 A 501 (-3.0A) | 0.84A | 5bs8A-2yzwA:undetectable5bs8C-2yzwA:undetectable5bs8D-2yzwA:undetectable | 5bs8A-2yzwA:19.885bs8C-2yzwA:19.885bs8D-2yzwA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ab0 | ANTIBODY SCFVFRAGMENT, LIGHTCHAINBCLA PROTEIN (Bacillusanthracis;Mus musculus) |
PF07686(V-set)no annotation | 4 | ALA C 26GLY A 157THR A 125GLU A 190 | None | 0.68A | 5bs8A-3ab0C:undetectable5bs8C-3ab0C:undetectable5bs8D-3ab0C:undetectable | 5bs8A-3ab0C:13.295bs8C-3ab0C:13.295bs8D-3ab0C:14.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bdl | STAPHYLOCOCCALNUCLEASEDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF00565(SNase)PF00567(TUDOR) | 4 | ALA A 713ARG A 707GLY A 708GLU A 550 | None | 0.84A | 5bs8A-3bdlA:undetectable5bs8C-3bdlA:undetectable5bs8D-3bdlA:undetectable | 5bs8A-3bdlA:22.045bs8C-3bdlA:22.045bs8D-3bdlA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c3n | DIHYDROOROTATEDEHYDROGENASE (Trypanosomacruzi) |
PF01180(DHO_dh) | 4 | ALA A 14ARG A 286GLY A 282GLU A 279 | ALA A 14 ( 0.0A)ARG A 286 ( 0.6A)GLY A 282 ( 0.0A)GLU A 279 ( 0.5A) | 0.86A | 5bs8A-3c3nA:undetectable5bs8C-3c3nA:undetectable5bs8D-3c3nA:undetectable | 5bs8A-3c3nA:20.955bs8C-3c3nA:20.955bs8D-3c3nA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c85 | PUTATIVEGLUTATHIONE-REGULATED POTASSIUM-EFFLUXSYSTEM PROTEIN KEFB (Vibrioparahaemolyticus) |
PF02254(TrkA_N) | 4 | ALA A 36ASP A 52GLY A 79GLU A 78 | None | 0.78A | 5bs8A-3c85A:undetectable5bs8C-3c85A:undetectable5bs8D-3c85A:3.0 | 5bs8A-3c85A:17.525bs8C-3c85A:17.525bs8D-3c85A:23.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ccf | CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPIDSYNTHASE (Trichormusvariabilis) |
PF08241(Methyltransf_11) | 4 | ALA A 124ASP A 89ARG A 91GLU A 113 | None | 0.78A | 5bs8A-3ccfA:undetectable5bs8C-3ccfA:undetectable5bs8D-3ccfA:undetectable | 5bs8A-3ccfA:20.555bs8C-3ccfA:20.555bs8D-3ccfA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d8x | THIOREDOXINREDUCTASE 1 (Saccharomycescerevisiae) |
PF07992(Pyr_redox_2) | 4 | ARG A 72GLY A 43THR A 84GLU A 33 | None | 0.83A | 5bs8A-3d8xA:undetectable5bs8C-3d8xA:undetectable5bs8D-3d8xA:undetectable | 5bs8A-3d8xA:23.135bs8C-3d8xA:23.135bs8D-3d8xA:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3da1 | GLYCEROL-3-PHOSPHATEDEHYDROGENASE (Bacillushalodurans) |
PF01266(DAO)PF16901(DAO_C) | 4 | ALA A 227ARG A 378GLY A 376GLU A 85 | None | 0.75A | 5bs8A-3da1A:undetectable5bs8C-3da1A:undetectable5bs8D-3da1A:undetectable | 5bs8A-3da1A:23.915bs8C-3da1A:23.915bs8D-3da1A:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dm3 | REPLICATION FACTOR A (Methanocaldococcusjannaschii) |
PF01336(tRNA_anti-codon) | 4 | ARG A 80GLY A 82THR A 57GLU A 88 | None NA A 901 (-3.5A)NoneNone | 0.91A | 5bs8A-3dm3A:undetectable5bs8C-3dm3A:undetectable5bs8D-3dm3A:undetectable | 5bs8A-3dm3A:13.065bs8C-3dm3A:13.065bs8D-3dm3A:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3epm | THIAMINEBIOSYNTHESIS PROTEINTHIC (Caulobactervibrioides) |
PF01964(ThiC_Rad_SAM)PF13667(ThiC-associated) | 4 | ASP A 117ARG A 265GLY A 74GLU A 202 | None | 0.75A | 5bs8A-3epmA:undetectable5bs8C-3epmA:undetectable5bs8D-3epmA:2.1 | 5bs8A-3epmA:22.775bs8C-3epmA:22.775bs8D-3epmA:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g2e | OORC SUBUNIT OF2-OXOGLUTARATE:ACCEPTOR OXIDOREDUCTASE (Campylobacterjejuni) |
PF01558(POR) | 4 | ASP A 56ARG A 31GLY A 30GLU A 29 | None | 0.85A | 5bs8A-3g2eA:undetectable5bs8C-3g2eA:undetectable5bs8D-3g2eA:undetectable | 5bs8A-3g2eA:17.825bs8C-3g2eA:17.825bs8D-3g2eA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gg2 | SUGAR DEHYDROGENASE,UDP-GLUCOSE/GDP-MANNOSE DEHYDROGENASEFAMILY (Porphyromonasgingivalis) |
PF00984(UDPG_MGDP_dh)PF03720(UDPG_MGDP_dh_C)PF03721(UDPG_MGDP_dh_N) | 4 | ALA A 82ARG A 186GLY A 185GLU A 215 | None | 0.86A | 5bs8A-3gg2A:undetectable5bs8C-3gg2A:undetectable5bs8D-3gg2A:undetectable | 5bs8A-3gg2A:24.005bs8C-3gg2A:24.005bs8D-3gg2A:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gxv | REPLICATIVE DNAHELICASE (Helicobacterpylori) |
PF00772(DnaB) | 4 | ARG A 108ALA A 104GLY A 46GLU A 50 | None | 0.91A | 5bs8A-3gxvA:undetectable5bs8C-3gxvA:undetectable5bs8D-3gxvA:undetectable | 5bs8A-3gxvA:13.505bs8C-3gxvA:13.505bs8D-3gxvA:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hri | HISTIDYL-TRNASYNTHETASE (Trypanosomabrucei) |
PF03129(HGTP_anticodon)PF13393(tRNA-synt_His) | 5 | ALA A 229ASP A 342ARG A 340GLY A 339GLU A 183 | None | 1.38A | 5bs8A-3hriA:undetectable5bs8C-3hriA:undetectable5bs8D-3hriA:undetectable | 5bs8A-3hriA:21.925bs8C-3hriA:21.925bs8D-3hriA:22.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ie1 | RIBONUCLEASETTHA0252 (Thermusthermophilus) |
PF00753(Lactamase_B)PF07521(RMMBL)PF10996(Beta-Casp) | 4 | ALA A 85GLY A 161THR A 188GLU A 186 | NoneNone U E 1 ( 4.9A)None | 0.92A | 5bs8A-3ie1A:undetectable5bs8C-3ie1A:undetectable5bs8D-3ie1A:undetectable | 5bs8A-3ie1A:22.935bs8C-3ie1A:22.935bs8D-3ie1A:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iha | SALT-TOLERANTGLUTAMINASE (Micrococcusluteus) |
PF04960(Glutaminase) | 4 | ALA A 391ARG A 431GLY A 428GLU A 427 | None | 0.86A | 5bs8A-3ihaA:undetectable5bs8C-3ihaA:undetectable5bs8D-3ihaA:undetectable | 5bs8A-3ihaA:23.845bs8C-3ihaA:23.845bs8D-3ihaA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3krz | NADH:FLAVINOXIDOREDUCTASE/NADHOXIDASE (Thermoanaerobacterpseudethanolicus) |
PF00724(Oxidored_FMN) | 5 | ALA A 123ASP A 114ARG A 64GLY A 65GLU A 62 | None | 1.10A | 5bs8A-3krzA:undetectable5bs8C-3krzA:undetectable5bs8D-3krzA:undetectable | 5bs8A-3krzA:22.495bs8C-3krzA:22.495bs8D-3krzA:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ly1 | PUTATIVEHISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Pectobacteriumatrosepticum) |
PF00155(Aminotran_1_2) | 4 | ALA A 256ASP A 310GLY A 332GLU A 331 | None | 0.85A | 5bs8A-3ly1A:3.55bs8C-3ly1A:3.45bs8D-3ly1A:undetectable | 5bs8A-3ly1A:22.315bs8C-3ly1A:22.315bs8D-3ly1A:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m07 | PUTATIVE ALPHAAMYLASE (Salmonellaenterica) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 4 | ALA A 271ASP A 236ARG A 240GLU A 244 | None | 0.88A | 5bs8A-3m07A:undetectable5bs8C-3m07A:undetectable5bs8D-3m07A:undetectable | 5bs8A-3m07A:22.355bs8C-3m07A:22.355bs8D-3m07A:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m07 | PUTATIVE ALPHAAMYLASE (Salmonellaenterica) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 4 | ALA A 338ASP A 402GLY A 396THR A 479 | None | 0.92A | 5bs8A-3m07A:undetectable5bs8C-3m07A:undetectable5bs8D-3m07A:undetectable | 5bs8A-3m07A:22.355bs8C-3m07A:22.355bs8D-3m07A:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3na0 | CHOLESTEROLSIDE-CHAIN CLEAVAGEENZYME,MITOCHONDRIAL (Homo sapiens) |
PF00067(p450) | 4 | ALA A 173ASP A 297ARG A 299GLY A 300 | None | 0.60A | 5bs8A-3na0A:1.75bs8C-3na0A:1.75bs8D-3na0A:undetectable | 5bs8A-3na0A:22.285bs8C-3na0A:22.285bs8D-3na0A:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nzu | PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE3-KINASE CATALYTICSUBUNIT GAMMAISOFORM (Homo sapiens) |
PF00454(PI3_PI4_kinase)PF00613(PI3Ka)PF00792(PI3K_C2)PF00794(PI3K_rbd) | 4 | ASP A 653ARG A 687GLY A 685GLU A 187 | None | 0.86A | 5bs8A-3nzuA:undetectable5bs8C-3nzuA:1.55bs8D-3nzuA:undetectable | 5bs8A-3nzuA:19.265bs8C-3nzuA:19.265bs8D-3nzuA:13.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o59 | DNA POLYMERASE IILARGE SUBUNIT (Pyrococcushorikoshii) |
PF03833(PolC_DP2) | 4 | ALA X 120ARG X 245GLY X 246GLU X 190 | None | 0.89A | 5bs8A-3o59X:undetectable5bs8C-3o59X:undetectable5bs8D-3o59X:undetectable | 5bs8A-3o59X:21.195bs8C-3o59X:21.195bs8D-3o59X:24.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ogz | UDP-SUGARPYROPHOSPHORYLASE (Leishmaniamajor) |
PF01704(UDPGP) | 4 | ALA A 566ASP A 609ARG A 551GLU A 534 | None | 0.85A | 5bs8A-3ogzA:undetectable5bs8C-3ogzA:undetectable5bs8D-3ogzA:undetectable | 5bs8A-3ogzA:23.795bs8C-3ogzA:23.795bs8D-3ogzA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p0w | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Ralstoniapickettii) |
PF13378(MR_MLE_C) | 4 | ALA A 90ARG A 62GLY A 60GLU A 59 | None | 0.80A | 5bs8A-3p0wA:undetectable5bs8C-3p0wA:undetectable5bs8D-3p0wA:undetectable | 5bs8A-3p0wA:23.405bs8C-3p0wA:23.405bs8D-3p0wA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qtg | PYRUVATE KINASE (Pyrobaculumaerophilum) |
PF00224(PK)PF02887(PK_C) | 4 | ALA A 387ASP A 198ARG A 410GLU A 68 | None | 0.85A | 5bs8A-3qtgA:undetectable5bs8C-3qtgA:undetectable5bs8D-3qtgA:undetectable | 5bs8A-3qtgA:21.965bs8C-3qtgA:21.965bs8D-3qtgA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qxm | GLUTAMATE RECEPTORIONOTROPIC, KAINATE2 (Homo sapiens) |
PF10613(Lig_chan-Glu_bd) | 4 | ARG A 450ASP A 476ARG A 472GLY A 469 | None | 0.82A | 5bs8A-3qxmA:undetectable5bs8C-3qxmA:undetectable5bs8D-3qxmA:undetectable | 5bs8A-3qxmA:22.015bs8C-3qxmA:22.015bs8D-3qxmA:25.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rc3 | ATP-DEPENDENT RNAHELICASE SUPV3L1,MITOCHONDRIAL (Homo sapiens) |
PF00271(Helicase_C)PF12513(SUV3_C) | 4 | ALA A 217ARG A 200THR A 336GLU A 338 | None | 0.88A | 5bs8A-3rc3A:undetectable5bs8C-3rc3A:undetectable5bs8D-3rc3A:2.4 | 5bs8A-3rc3A:22.365bs8C-3rc3A:22.365bs8D-3rc3A:16.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rxy | NIF3 PROTEIN (Sphaerobacterthermophilus) |
no annotation | 4 | ALA A 167ARG A 141GLY A 140GLU A 138 | None | 0.80A | 5bs8A-3rxyA:undetectable5bs8C-3rxyA:undetectable5bs8D-3rxyA:undetectable | 5bs8A-3rxyA:20.685bs8C-3rxyA:20.685bs8D-3rxyA:23.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t7v | METHYLORNITHINESYNTHASE PYLB (Methanosarcinabarkeri) |
PF04055(Radical_SAM) | 4 | ARG A 48ARG A 289THR A 238GLU A 258 | None | 0.74A | 5bs8A-3t7vA:undetectable5bs8C-3t7vA:undetectable5bs8D-3t7vA:undetectable | 5bs8A-3t7vA:24.865bs8C-3t7vA:24.865bs8D-3t7vA:23.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tt2 | GCN5-RELATEDN-ACETYLTRANSFERASE (Sphaerobacterthermophilus) |
PF00583(Acetyltransf_1) | 4 | ALA A 261GLY A 237THR A 210GLU A 213 | SO4 A 331 (-3.8A)NoneNoneNone | 0.86A | 5bs8A-3tt2A:undetectable5bs8C-3tt2A:undetectable5bs8D-3tt2A:undetectable | 5bs8A-3tt2A:21.295bs8C-3tt2A:21.295bs8D-3tt2A:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u4a | JMB19063 (compostmetagenome) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 4 | ASP A 194ARG A 142GLY A 487GLU A 145 | NoneBGC A 776 (-2.9A)NoneNone | 0.87A | 5bs8A-3u4aA:undetectable5bs8C-3u4aA:undetectable5bs8D-3u4aA:2.6 | 5bs8A-3u4aA:21.825bs8C-3u4aA:21.825bs8D-3u4aA:16.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u4g | NAMN:DMBPHOSPHORIBOSYLTRANSFERASE (Pyrococcushorikoshii) |
no annotation | 4 | ASP A 105ARG A 107GLY A 181GLU A 180 | ACY A 339 (-3.7A)ACY A 339 (-4.1A)NoneACY A 339 (-4.4A) | 0.88A | 5bs8A-3u4gA:undetectable5bs8C-3u4gA:undetectable5bs8D-3u4gA:undetectable | 5bs8A-3u4gA:23.485bs8C-3u4gA:23.485bs8D-3u4gA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ue1 | PENICILLIN-BINDINGPROTEIN 1A (Acinetobacterbaumannii) |
PF00905(Transpeptidase)PF00912(Transgly)PF17092(PCB_OB) | 4 | ARG A 294ALA A 290GLY A 709THR A 435 | NoneNoneUE1 A 998 (-3.9A)None | 0.78A | 5bs8A-3ue1A:undetectable5bs8C-3ue1A:undetectable5bs8D-3ue1A:undetectable | 5bs8A-3ue1A:21.905bs8C-3ue1A:21.905bs8D-3ue1A:18.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w5n | PUTATIVERHAMNOSIDASE (Streptomycesavermitilis) |
PF05592(Bac_rhamnosid)PF08531(Bac_rhamnosid_N)PF17389(Bac_rhamnosid6H)PF17390(Bac_rhamnosid_C) | 4 | ALA A 344ARG A 320GLY A 19GLU A 109 | NoneNone NA A1212 ( 4.6A)None | 0.89A | 5bs8A-3w5nA:3.25bs8C-3w5nA:undetectable5bs8D-3w5nA:undetectable | 5bs8A-3w5nA:20.895bs8C-3w5nA:20.895bs8D-3w5nA:13.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wqy | ALANINE--TRNA LIGASE (Archaeoglobusfulgidus) |
PF01411(tRNA-synt_2c)PF02272(DHHA1)PF07973(tRNA_SAD) | 4 | ALA A 192ARG A 234GLY A 224GLU A 223 | None | 0.88A | 5bs8A-3wqyA:2.85bs8C-3wqyA:2.85bs8D-3wqyA:undetectable | 5bs8A-3wqyA:21.705bs8C-3wqyA:21.705bs8D-3wqyA:15.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zyv | AOX3 (Mus musculus) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 4 | ALA A 353ASP A 51GLY A 149THR A1238 | FAD A3005 (-3.6A)NoneNoneNone | 0.83A | 5bs8A-3zyvA:undetectable5bs8C-3zyvA:undetectable5bs8D-3zyvA:undetectable | 5bs8A-3zyvA:16.255bs8C-3zyvA:16.255bs8D-3zyvA:11.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zyv | AOX3 (Mus musculus) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 4 | ARG A 429ALA A 431GLY A 346THR A 75 | FAD A3005 ( 4.9A)NoneNoneFES A3002 ( 4.3A) | 0.85A | 5bs8A-3zyvA:undetectable5bs8C-3zyvA:undetectable5bs8D-3zyvA:undetectable | 5bs8A-3zyvA:16.255bs8C-3zyvA:16.255bs8D-3zyvA:11.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a7k | ALDOS-2-ULOSEDEHYDRATASE (Phanerochaetechrysosporium) |
no annotation | 4 | ARG A 319GLY A 271THR A 298GLU A 292 | None | 0.80A | 5bs8A-4a7kA:undetectable5bs8C-4a7kA:undetectable5bs8D-4a7kA:undetectable | 5bs8A-4a7kA:20.495bs8C-4a7kA:20.495bs8D-4a7kA:16.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bfr | PHOSPHATIDYLINOSITOL4,5-BISPHOSPHATE3-KINASE CATALYTIC SSUBUNIT BETA ISOFORM (Mus musculus) |
PF00454(PI3_PI4_kinase)PF00613(PI3Ka)PF00792(PI3K_C2)PF00794(PI3K_rbd) | 5 | ALA A 905ASP A 827ARG A 829THR A 924GLU A 894 | None | 1.17A | 5bs8A-4bfrA:undetectable5bs8C-4bfrA:undetectable5bs8D-4bfrA:undetectable | 5bs8A-4bfrA:18.115bs8C-4bfrA:18.115bs8D-4bfrA:15.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ewp | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 (Micrococcusluteus) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 4 | ARG A 23ALA A 315ARG A 53GLY A 169 | None | 0.88A | 5bs8A-4ewpA:undetectable5bs8C-4ewpA:undetectable5bs8D-4ewpA:undetectable | 5bs8A-4ewpA:25.515bs8C-4ewpA:25.515bs8D-4ewpA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4glt | GLUTATHIONES-TRANSFERASE-LIKEPROTEIN (Methylobacillusflagellatus) |
PF13410(GST_C_2)PF13417(GST_N_3) | 4 | ALA A 158ASP A 140ARG A 136GLY A 133 | None | 0.88A | 5bs8A-4gltA:undetectable5bs8C-4gltA:undetectable5bs8D-4gltA:undetectable | 5bs8A-4gltA:18.275bs8C-4gltA:18.275bs8D-4gltA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gu7 | PUTATIVEUNCHARACTERIZEDPROTEIN SCO7193 (Streptomycescoelicolor) |
PF04261(Dyp_perox) | 4 | ALA A 165ASP A 244GLY A 153GLU A 144 | NoneNoneHEM A 401 (-3.4A)None | 0.92A | 5bs8A-4gu7A:1.45bs8C-4gu7A:1.55bs8D-4gu7A:undetectable | 5bs8A-4gu7A:23.195bs8C-4gu7A:23.195bs8D-4gu7A:26.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kf7 | NUP188 (Thermothelomycesthermophila) |
PF10487(Nup188) | 5 | ASP A 764ARG A 767GLY A 768THR A 629GLU A 756 | None | 1.11A | 5bs8A-4kf7A:undetectable5bs8C-4kf7A:undetectable5bs8D-4kf7A:undetectable | 5bs8A-4kf7A:18.935bs8C-4kf7A:18.935bs8D-4kf7A:13.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mpt | PUTATIVELEU/ILE/VAL-BINDINGPROTEIN (Bordetellapertussis) |
PF13458(Peripla_BP_6) | 4 | ALA A 275ARG A 24GLY A 22GLU A 21 | None | 0.86A | 5bs8A-4mptA:undetectable5bs8C-4mptA:undetectable5bs8D-4mptA:4.2 | 5bs8A-4mptA:23.505bs8C-4mptA:23.505bs8D-4mptA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o6m | AF2299, ACDP-ALCOHOLPHOSPHOTRANSFERASE (Archaeoglobusfulgidus) |
PF01066(CDP-OH_P_transf) | 4 | ALA A 221ASP A 148ARG A 301GLY A 236 | None CA A 401 (-3.7A)NoneNone | 0.89A | 5bs8A-4o6mA:undetectable5bs8C-4o6mA:undetectable5bs8D-4o6mA:undetectable | 5bs8A-4o6mA:20.705bs8C-4o6mA:20.705bs8D-4o6mA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p3w | FILAMIN-A (Homo sapiens) |
PF00630(Filamin) | 4 | ALA A2266ASP A2290ARG A2288GLU A2286 | None | 0.83A | 5bs8A-4p3wA:undetectable5bs8C-4p3wA:undetectable5bs8D-4p3wA:undetectable | 5bs8A-4p3wA:15.515bs8C-4p3wA:15.515bs8D-4p3wA:23.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q0s | L-RIBOSE ISOMERASE (Acinetobactersp. DL-28) |
no annotation | 4 | ALA A 49ARG A 243GLY A 242THR A 213 | NoneRB0 A 502 (-3.8A)NoneNone | 0.81A | 5bs8A-4q0sA:undetectable5bs8C-4q0sA:undetectable5bs8D-4q0sA:undetectable | 5bs8A-4q0sA:17.685bs8C-4q0sA:17.685bs8D-4q0sA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q2b | ENDO-1,4-BETA-D-GLUCANASE (Pseudomonasputida) |
PF01270(Glyco_hydro_8) | 5 | ALA A 203ASP A 193ARG A 190GLY A 358GLU A 127 | NoneNoneFMT A 405 (-3.1A)NoneNone | 1.41A | 5bs8A-4q2bA:undetectable5bs8C-4q2bA:undetectable5bs8D-4q2bA:undetectable | 5bs8A-4q2bA:21.845bs8C-4q2bA:21.845bs8D-4q2bA:24.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rgz | XAA-PROAMINOPEPTIDASE (Thermococcussibiricus) |
no annotation | 4 | ALA A 180ASP A 224ARG A 221GLY A 173 | None | 0.90A | 5bs8A-4rgzA:undetectable5bs8C-4rgzA:undetectable5bs8D-4rgzA:undetectable | 5bs8A-4rgzA:21.595bs8C-4rgzA:21.595bs8D-4rgzA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rvw | ZNUD (Neisseriameningitidis) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 4 | ALA A 384ASP A 95GLY A 91GLU A 89 | None | 0.90A | 5bs8A-4rvwA:undetectable5bs8C-4rvwA:undetectable5bs8D-4rvwA:undetectable | 5bs8A-4rvwA:21.565bs8C-4rvwA:21.565bs8D-4rvwA:16.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4up3 | THIOREDOXINREDUCTASE (Entamoebahistolytica) |
PF07992(Pyr_redox_2) | 4 | ARG A 73GLY A 44THR A 85GLU A 34 | None | 0.83A | 5bs8A-4up3A:undetectable5bs8C-4up3A:undetectable5bs8D-4up3A:undetectable | 5bs8A-4up3A:21.635bs8C-4up3A:21.635bs8D-4up3A:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y9l | PROTEIN ACDH-11,ISOFORM B (Caenorhabditiselegans) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M) | 4 | ALA A 394ASP A 49ARG A 346GLY A 343 | None | 0.85A | 5bs8A-4y9lA:undetectable5bs8C-4y9lA:undetectable5bs8D-4y9lA:undetectable | 5bs8A-4y9lA:25.005bs8C-4y9lA:25.005bs8D-4y9lA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yrp | HISTIDYL-TRNASYNTHETASE (Trypanosomacruzi) |
PF03129(HGTP_anticodon)PF13393(tRNA-synt_His) | 4 | ARG A 196ASP A 304GLY A 301GLU A 298 | SO4 A 508 ( 4.0A)NoneNoneNone | 0.80A | 5bs8A-4yrpA:undetectable5bs8C-4yrpA:undetectable5bs8D-4yrpA:undetectable | 5bs8A-4yrpA:22.025bs8C-4yrpA:22.025bs8D-4yrpA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zdn | AT-LESS POLYKETIDESYNTHASE (Streptomycesplatensis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 4 | ARG A1106GLY A1105THR A1009GLU A1047 | NoneNone CL A1202 ( 4.4A)None | 0.91A | 5bs8A-4zdnA:undetectable5bs8C-4zdnA:undetectable5bs8D-4zdnA:undetectable | 5bs8A-4zdnA:22.695bs8C-4zdnA:22.695bs8D-4zdnA:17.34 |