SIMILAR PATTERNS OF AMINO ACIDS FOR 5BR1_A_X6XA401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2hvq	HYPOTHETICAL 37.6 KDA PROTEIN IN GP24-HOC INTERGENIC REGION (Escherichia virus T4)	PF09414 (RNA_ligase)	5	ASP A 180 ASP A 113 ASP A 292 HIS A 181 ASN A 265	None	1.23A	5br1A-2hvqA: 0.0	5br1A-2hvqA: 23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4rxm	POSSIBLE SUGAR ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN (Mannheimia haemolytica)	PF13407 (Peripla_BP_4)	5	PHE A 38 ASP A 112 ARG A 113 TRP A 189 GLN A 263	INS A 401 (-4.5A) INS A 401 (-2.6A) INS A 401 (-3.8A) INS A 401 (-3.6A) INS A 401 (-3.3A)	0.78A	5br1A-4rxmA: 35.4	5br1A-4rxmA: 24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ry0	PROBABLE RIBOSE ABC TRANSPORTER, SUBSTRATE-BINDING PROTEIN (Rhizobium etli)	PF13407 (Peripla_BP_4)	6	PHE A 41 ASP A 115 ARG A 116 ASP A 162 TRP A 192 GLN A 263	RIP A 401 ( 4.0A) RIP A 401 (-2.8A) RIP A 401 (-3.9A) RIP A 401 (-3.0A) RIP A 401 (-3.5A) RIP A 401 (-3.2A)	0.62A	5br1A-4ry0A: 35.3	5br1A-4ry0A: 28.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4y9t	ABC TRANSPORTER, SOLUTE BINDING PROTEIN (Agrobacterium vitis)	PF13407 (Peripla_BP_4)	11	ASP A 39 PHE A 41 GLN A 42 ASP A 115 ARG A 116 ASP A 166 TYR A 168 TRP A 196 HIS A 224 ASN A 249 GLN A 269	PA1 A 401 (-2.8A) PA1 A 401 (-3.6A) PA1 A 401 (-3.8A) PA1 A 401 (-3.0A) PA1 A 401 (-4.0A) PA1 A 401 (-3.1A) PA1 A 401 (-3.1A) PA1 A 401 (-3.6A) PA1 A 401 (-4.5A) PA1 A 401 (-4.0A) PA1 A 401 (-3.0A)	0.15A	5br1A-4y9tA: 55.4	5br1A-4y9tA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4ywh	ABC TRANSPORTER SOLUTE BINDING PROTEIN (Actinobacillus succinogenes)	PF13407 (Peripla_BP_4)	5	ASP A 245 ASP A 113 ARG A 114 ASP A 158 TRP A 192	XYP A 401 (-2.4A) XYP A 401 (-3.3A) XYP A 401 (-3.9A) XYP A 401 (-2.8A) XYP A 401 (-3.2A)	1.12A	5br1A-4ywhA: 35.8	5br1A-4ywhA: 31.37

[["5BR1_A_X6XA401_1","2hvq","Escherichia virus T4","HYPOTHETICAL 37.6 KDA PROTEIN IN GP24-HOC INTERGENIC REGION","PF09414(RNA_ligase)",5,"ASP A 180;ASP A 113;ASP A 292;HIS A 181;ASN A 265","None","1.23A","5br1A-2hvqA:0.0","5br1A-2hvqA:23.84"],["5BR1_A_X6XA401_1","4rxm","Mannheimia haemolytica","POSSIBLE SUGAR ABC SUPERFAMILY ATP BINDING CASSETTE TRANSPORTER, BINDING PROTEIN","PF13407(Peripla_BP_4)",5,"PHE A  38;ASP A 112;ARG A 113;TRP A 189;GLN A 263","INS A 401 (-4.5A);INS A 401 (-2.6A);INS A 401 (-3.8A);INS A 401 (-3.6A);INS A 401 (-3.3A)","0.78A","5br1A-4rxmA:35.4","5br1A-4rxmA:24.93"],["5BR1_A_X6XA401_1","4ry0","Rhizobium etli","PROBABLE RIBOSE ABC TRANSPORTER, SUBSTRATE-BINDING PROTEIN","PF13407(Peripla_BP_4)",6,"PHE A  41;ASP A 115;ARG A 116;ASP A 162;TRP A 192;GLN A 263","RIP A 401 ( 4.0A);RIP A 401 (-2.8A);RIP A 401 (-3.9A);RIP A 401 (-3.0A);RIP A 401 (-3.5A);RIP A 401 (-3.2A)","0.62A","5br1A-4ry0A:35.3","5br1A-4ry0A:28.37"],["5BR1_A_X6XA401_1","4y9t","Agrobacterium vitis","ABC TRANSPORTER, SOLUTE BINDING PROTEIN","PF13407(Peripla_BP_4)",11,"ASP A  39;PHE A  41;GLN A  42;ASP A 115;ARG A 116;ASP A 166;TYR A 168;TRP A 196;HIS A 224;ASN A 249;GLN A 269","PA1 A 401 (-2.8A);PA1 A 401 (-3.6A);PA1 A 401 (-3.8A);PA1 A 401 (-3.0A);PA1 A 401 (-4.0A);PA1 A 401 (-3.1A);PA1 A 401 (-3.1A);PA1 A 401 (-3.6A);PA1 A 401 (-4.5A);PA1 A 401 (-4.0A);PA1 A 401 (-3.0A)","0.15A","5br1A-4y9tA:55.4","5br1A-4y9tA:100.00"],["5BR1_A_X6XA401_1","4ywh","Actinobacillus succinogenes","ABC TRANSPORTER SOLUTE BINDING PROTEIN","PF13407(Peripla_BP_4)",5,"ASP A 245;ASP A 113;ARG A 114;ASP A 158;TRP A 192","XYP A 401 (-2.4A);XYP A 401 (-3.3A);XYP A 401 (-3.9A);XYP A 401 (-2.8A);XYP A 401 (-3.2A)","1.12A","5br1A-4ywhA:35.8","5br1A-4ywhA:31.37"]]