SIMILAR PATTERNS OF AMINO ACIDS FOR 5BPH_D_ACTD406

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iov D-ALA:D-ALA LIGASE

(Escherichia
coli) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 LYS A 215
ARG A 255
ASN A 272
GLY A 276
 POB  A 321 (-2.5A)
POB  A 321 (-3.2A)
MG  A 331 (-2.8A)
POB  A 321 (-3.2A)
 1.10A 5bphD-1iovA:
42.4		 5bphD-1iovA:
73.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 4 LYS A 156
ARG A 171
ASN A 193
GLY A 196
 None
 1.28A 5bphD-6emkA:
undetectable		 5bphD-6emkA:
undetectable