SIMILAR PATTERNS OF AMINO ACIDS FOR 5BPH_B_ACTB403_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1iov	D-ALA:D-ALA LIGASE (Escherichia coli)	PF01820 (Dala_Dala_lig_N) PF07478 (Dala_Dala_lig_C)	5	LYS A 215 TYR A 216 ARG A 255 ASN A 272 GLY A 276	POB A 321 (-2.5A) None POB A 321 (-3.2A) MG A 331 (-2.8A) POB A 321 (-3.2A)	0.97A	5bphB-1iovA: 18.3	5bphB-1iovA: 73.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3hd6	AMMONIUM TRANSPORTER RH TYPE C (Homo sapiens)	PF00909 (Ammonium_transp)	4	TYR A 435 ARG A 10 ASN A 4 GLY A 422	None	1.44A	5bphB-3hd6A: 0.0	5bphB-3hd6A: 21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4zlg	PUTATIVE B-GLYCAN PHOSPHORYLASE (Saccharophagus degradans)	PF06165 (Glyco_transf_36) PF17167 (Glyco_hydro_36)	4	TYR A 624 ARG A 341 ASN A 350 GLY A 695	SO4 A 805 ( 4.7A) SO4 A 805 (-3.0A) LGC A 804 (-3.0A) SO4 A 805 (-3.8A)	1.33A	5bphB-4zlgA: 0.0	5bphB-4zlgA: 18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5fsw	RNA DEPENDENT RNA POLYMERASE QDE-1 (Thielavia terrestris)	PF05183 (RdRP)	4	LYS A 771 TYR A 770 ARG A 713 ASN A 709	None	1.22A	5bphB-5fswA: 0.0	5bphB-5fswA: 15.38

[["5BPH_B_ACTB403_0","1iov","Escherichia coli","D-ALA:D-ALA LIGASE","PF01820(Dala_Dala_lig_N);PF07478(Dala_Dala_lig_C)",5,"LYS A 215;TYR A 216;ARG A 255;ASN A 272;GLY A 276","POB A 321 (-2.5A);None;POB A 321 (-3.2A); MG A 331 (-2.8A);POB A 321 (-3.2A)","0.97A","5bphB-1iovA:18.3","5bphB-1iovA:73.29"],["5BPH_B_ACTB403_0","3hd6","Homo sapiens","AMMONIUM TRANSPORTER RH TYPE C","PF00909(Ammonium_transp)",4,"TYR A 435;ARG A  10;ASN A   4;GLY A 422","None","1.44A","5bphB-3hd6A:0.0","5bphB-3hd6A:21.71"],["5BPH_B_ACTB403_0","4zlg","Saccharophagus degradans","PUTATIVE B-GLYCAN PHOSPHORYLASE","PF06165(Glyco_transf_36);PF17167(Glyco_hydro_36)",4,"TYR A 624;ARG A 341;ASN A 350;GLY A 695","SO4 A 805 ( 4.7A);SO4 A 805 (-3.0A);LGC A 804 (-3.0A);SO4 A 805 (-3.8A)","1.33A","5bphB-4zlgA:0.0","5bphB-4zlgA:18.56"],["5BPH_B_ACTB403_0","5fsw","Thielavia terrestris","RNA DEPENDENT RNA POLYMERASE QDE-1","PF05183(RdRP)",4,"LYS A 771;TYR A 770;ARG A 713;ASN A 709","None","1.22A","5bphB-5fswA:0.0","5bphB-5fswA:15.38"]]