SIMILAR PATTERNS OF AMINO ACIDS FOR 5BOJ_A_4TXA201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b35 PROTEIN (CRICKET
PARALYSIS VIRUS,
VP3)


(Cricket
paralysis virus)
no annotation 4 LYS C 198
LEU C 205
LEU C 196
SER C 193
None
1.02A 5bojA-1b35C:
undetectable
5bojA-1b35C:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cs1 PROTEIN
(CYSTATHIONINE
GAMMA-SYNTHASE)


(Escherichia
coli)
PF01053
(Cys_Met_Meta_PP)
4 LEU A 372
LEU A 320
SER A 319
THR A 322
None
1.07A 5bojA-1cs1A:
undetectable
5bojA-1cs1A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6b GLUTATHIONE
S-TRANSFERASE


(Arabidopsis
thaliana)
PF13409
(GST_N_2)
PF14497
(GST_C_3)
4 LEU A 147
ALA A 159
LEU A 150
THR A 160
None
None
None
BME  A 389 ( 4.9A)
1.03A 5bojA-1e6bA:
undetectable
5bojA-1e6bA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE


(Borreliella
burgdorferi)
PF00478
(IMPDH)
4 LEU A 287
ALA A 289
SER A  48
THR A  52
None
1.08A 5bojA-1eepA:
undetectable
5bojA-1eepA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g65 PROTEASOME COMPONENT
PUP3


(Saccharomyces
cerevisiae)
PF00227
(Proteasome)
4 LEU I 159
ALA I 130
SER I 127
THR I 129
None
1.08A 5bojA-1g65I:
undetectable
5bojA-1g65I:
26.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus)
PF00576
(Transthyretin)
6 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
THR A 119
None
0.50A 5bojA-1gkeA:
22.1
5bojA-1gkeA:
83.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE


(Escherichia
coli)
PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C)
5 LEU A 119
ALA A 256
LEU A 122
SER A 123
THR A 128
None
1.40A 5bojA-1guqA:
0.0
5bojA-1guqA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gut MOLYBDATE BINDING
PROTEIN II


(Clostridium
pasteurianum)
PF03459
(TOBE)
4 LYS A  18
LEU A  16
ALA A  23
SER A  37
None
1.01A 5bojA-1gutA:
undetectable
5bojA-1gutA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747


(Methanothermobacter
thermautotrophicus)
PF03807
(F420_oxidored)
PF09130
(DUF1932)
4 LEU A 183
ALA A 179
LEU A 185
THR A 176
None
0.96A 5bojA-1i36A:
undetectable
5bojA-1i36A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE


(Pyrococcus
horikoshii)
PF00291
(PALP)
4 LEU A  94
ALA A  90
LEU A  96
THR A  87
None
0.94A 5bojA-1j0aA:
undetectable
5bojA-1j0aA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis)
PF12468
(TTSSLRR)
4 LEU A1081
ALA A1098
LEU A1083
SER A1085
None
1.06A 5bojA-1jl5A:
undetectable
5bojA-1jl5A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k25 LOW-AFFINITY
PENICILLIN-BINDING
PROTEIN 2X


(Streptococcus
pneumoniae)
PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA)
4 LEU A 585
ALA A 291
LEU A 293
THR A 305
None
0.82A 5bojA-1k25A:
undetectable
5bojA-1k25A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miu BREAST CANCER TYPE 2
SUSCEPTIBILITY
PROTEIN


(Mus musculus)
PF09103
(BRCA-2_OB1)
PF09104
(BRCA-2_OB3)
PF09121
(Tower)
PF09169
(BRCA-2_helical)
4 LEU A2906
ALA A2948
LEU A2946
SER A2933
None
0.99A 5bojA-1miuA:
undetectable
5bojA-1miuA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3w CYSTEINE DESULFURASE

(Escherichia
coli)
no annotation 4 LEU B 344
ALA B 341
LEU B 339
THR B 102
None
0.89A 5bojA-1p3wB:
undetectable
5bojA-1p3wB:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvk ISOMERASE/LACTONIZIN
G ENZYME


(Agrobacterium
fabrum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ALA A  36
LEU A  38
SER A  50
THR A  52
None
1.01A 5bojA-1rvkA:
undetectable
5bojA-1rvkA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT


(Thauera
aromatica)
PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C)
4 LEU B 252
ALA B 240
LEU B 242
SER B 219
None
0.93A 5bojA-1sb3B:
undetectable
5bojA-1sb3B:
16.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata)
PF00576
(Transthyretin)
5 LYS A  15
LEU A  17
ALA A 108
LEU A 110
THR A 119
None
0.72A 5bojA-1sn2A:
20.5
5bojA-1sn2A:
54.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli)
PF01029
(NusB)
PF01189
(Methyltr_RsmB-F)
5 LEU A 352
ALA A 323
LEU A 349
SER A 326
THR A 374
None
1.38A 5bojA-1sqgA:
undetectable
5bojA-1sqgA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy6 OKT3 FAB HEAVY CHAIN

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 LEU H   4
ALA H  79
SER H  77
THR H  72
None
0.95A 5bojA-1sy6H:
3.7
5bojA-1sy6H:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4n RIBONUCLEASE III

(Saccharomyces
cerevisiae)
PF00035
(dsrm)
4 LYS A 443
ALA A 446
LEU A 377
SER A 376
None
1.00A 5bojA-1t4nA:
undetectable
5bojA-1t4nA:
22.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus)
PF00576
(Transthyretin)
5 LYS A  15
LEU A  17
ALA A 108
LEU A 110
THR A 119
None
0.72A 5bojA-1tfpA:
19.6
5bojA-1tfpA:
73.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus)
PF00576
(Transthyretin)
4 LYS A  15
LEU A  17
LEU A 110
SER A 117
None
0.89A 5bojA-1tfpA:
19.6
5bojA-1tfpA:
73.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uun MSPA

(Mycolicibacterium
smegmatis)
PF09203
(MspA)
4 LEU A  62
ALA A 164
LEU A 166
THR A 176
None
0.61A 5bojA-1uunA:
3.2
5bojA-1uunA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvi PUTATIVE
PHOSPHATASES
INVOLVED IN
N-ACETYL-GLUCOSAMINE
CATABOLISM


(Streptococcus
mutans)
PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6)
4 LEU A1223
LEU A1246
SER A1247
THR A1227
None
1.07A 5bojA-1wviA:
undetectable
5bojA-1wviA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg2 PECTINESTERASE 1

(Solanum
lycopersicum)
PF01095
(Pectinesterase)
4 LYS A 107
ALA A 103
LEU A  71
THR A 102
None
1.04A 5bojA-1xg2A:
undetectable
5bojA-1xg2A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls ORPHAN NUCLEAR
RECEPTOR NR1I3


(Mus musculus)
PF00104
(Hormone_recep)
4 LEU E 191
ALA E 274
LEU E 294
THR E 275
None
1.02A 5bojA-1xlsE:
undetectable
5bojA-1xlsE:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xx0 PLECKSTRIN

(Homo sapiens)
PF00169
(PH)
4 LEU A 275
ALA A 341
LEU A 292
SER A 346
None
1.04A 5bojA-1xx0A:
undetectable
5bojA-1xx0A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE


(Novosphingobium
capsulatum)
PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N)
4 LEU A 684
ALA A 649
LEU A 651
SER A 596
None
0.69A 5bojA-1yr2A:
undetectable
5bojA-1yr2A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli)
PF01144
(CoA_trans)
4 LEU A  41
ALA A  36
LEU A  34
THR A  69
None
1.08A 5bojA-2ahwA:
undetectable
5bojA-2ahwA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR


(Escherichia
coli)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF)
4 LEU A 939
ALA A 910
LEU A 784
SER A 906
EPE  A1151 (-4.0A)
None
None
EPE  A1152 (-2.8A)
0.96A 5bojA-2eyqA:
undetectable
5bojA-2eyqA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6c CHLOROPHENOL
REDUCTION GENE K


(Desulfitobacterium
dehalogenans)
PF13545
(HTH_Crp_2)
4 LEU A 201
LEU A 198
SER A 195
THR A 193
None
1.07A 5bojA-2h6cA:
1.9
5bojA-2h6cA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jft SER-THR PHOSPHATASE
MSPP


(Mycolicibacterium
smegmatis)
PF13672
(PP2C_2)
4 LEU A  79
LEU A  80
SER A  87
THR A  89
None
1.01A 5bojA-2jftA:
undetectable
5bojA-2jftA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jre C60-1 PDZ DOMAIN
PEPTIDE


(-)
PF00595
(PDZ)
4 LYS A  68
LEU A  70
LEU A  99
SER A  15
None
0.83A 5bojA-2jreA:
undetectable
5bojA-2jreA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kc3 APOLIPOPROTEIN E

(Homo sapiens)
PF01442
(Apolipoprotein)
4 LEU A  78
ALA A 164
SER A  22
THR A  18
None
0.98A 5bojA-2kc3A:
undetectable
5bojA-2kc3A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kz8 UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YGIT


(Escherichia
coli)
PF15731
(MqsA_antitoxin)
5 LEU A 120
ALA A  88
LEU A  81
SER A  82
THR A  84
None
1.37A 5bojA-2kz8A:
undetectable
5bojA-2kz8A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlz CEPHALOSPORIN
ACYLASE


(Bacillus
halodurans)
PF01019
(G_glu_transpept)
5 LEU A 208
ALA A  57
LEU A 142
SER A 141
THR A  54
None
1.21A 5bojA-2nlzA:
undetectable
5bojA-2nlzA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3j UDP-GLUCOSE
6-DEHYDROGENASE


(Caenorhabditis
elegans)
PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N)
4 LEU A 291
ALA A 304
LEU A 294
SER A 297
None
1.04A 5bojA-2o3jA:
undetectable
5bojA-2o3jA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pv7 T-PROTEIN [INCLUDES:
CHORISMATE MUTASE
(EC 5.4.99.5) (CM)
AND PREPHENATE
DEHYDROGENASE (EC
1.3.1.12) (PDH)]


(Haemophilus
influenzae)
PF02153
(PDH)
4 LEU A 199
ALA A 175
LEU A 177
SER A 151
None
None
None
NAD  A 400 (-3.8A)
1.00A 5bojA-2pv7A:
undetectable
5bojA-2pv7A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9u MSPA

(Mycolicibacterium
smegmatis)
PF09203
(MspA)
4 LEU A  62
ALA A 164
LEU A 166
THR A 176
LEU  A  62 ( 0.5A)
ALA  A 164 ( 0.0A)
LEU  A 166 ( 0.5A)
THR  A 176 ( 0.8A)
0.56A 5bojA-2v9uA:
3.2
5bojA-2v9uA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6d DYNAMIN FAMILY
PROTEIN


(Nostoc
punctiforme)
PF00350
(Dynamin_N)
4 LEU A  49
ALA A  38
LEU A  51
THR A  34
None
0.70A 5bojA-2w6dA:
undetectable
5bojA-2w6dA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X


(Streptococcus
pneumoniae)
PF00905
(Transpeptidase)
4 LEU B 585
ALA B 291
LEU B 293
THR B 305
None
0.79A 5bojA-2z2mB:
undetectable
5bojA-2z2mB:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6g B-CATENIN

(Danio rerio)
PF00514
(Arm)
4 LEU A 404
ALA A 420
LEU A 407
THR A 417
None
1.04A 5bojA-2z6gA:
undetectable
5bojA-2z6gA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN


(Thermus
thermophilus)
PF02355
(SecD_SecF)
PF07549
(Sec_GG)
4 LEU A  92
ALA A 261
LEU A  95
SER A  96
None
0.97A 5bojA-3aqpA:
undetectable
5bojA-3aqpA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE


(Homo sapiens)
PF00198
(2-oxoacid_dh)
4 LEU A 482
ALA A 503
SER A 527
THR A 529
None
0.84A 5bojA-3b8kA:
undetectable
5bojA-3b8kA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN


(Homo sapiens)
PF00059
(Lectin_C)
4 LEU B 216
ALA B 209
LEU B 211
SER B 173
None
0.94A 5bojA-3bdwB:
undetectable
5bojA-3bdwB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjl LOC - LAMBDA 1 TYPE
LIGHT-CHAIN DIMER


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 LYS A  46
ALA A  44
LEU A  40
SER A  41
None
0.81A 5bojA-3bjlA:
undetectable
5bojA-3bjlA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3d LYSOZYME

(Escherichia
virus Lambda)
PF00959
(Phage_lysozyme)
4 LEU A  12
LEU A  15
SER A  18
THR A  21
None
1.00A 5bojA-3d3dA:
undetectable
5bojA-3d3dA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]


(Escherichia
coli)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
4 LEU A  32
ALA A 164
LEU A  29
SER A  28
None
None
None
PO4  A 614 (-2.7A)
0.88A 5bojA-3eyaA:
undetectable
5bojA-3eyaA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4m TUMOR NECROSIS
FACTOR,
ALPHA-INDUCED
PROTEIN 8-LIKE
PROTEIN 2


(Homo sapiens)
PF05527
(DUF758)
4 LEU A  42
LEU A  39
SER A  36
THR A  34
None
1.08A 5bojA-3f4mA:
undetectable
5bojA-3f4mA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens)
PF00576
(Transthyretin)
6 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
0.51A 5bojA-3fc8A:
24.1
5bojA-3fc8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcm HYDROLASE, NUDIX
FAMILY


(Clostridium
perfringens)
PF00293
(NUDIX)
4 LEU A 130
LEU A  44
SER A  76
THR A  36
None
1.05A 5bojA-3fcmA:
undetectable
5bojA-3fcmA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB


(Aggregatibacter
actinomycetemcomitans)
PF12704
(MacB_PCD)
4 LEU A 461
ALA A 377
LEU A 379
SER A 363
None
0.90A 5bojA-3ftjA:
undetectable
5bojA-3ftjA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go1 FAB 268-D, LIGHT
CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 LEU L 132
ALA L 130
LEU L 178
THR L 181
None
1.04A 5bojA-3go1L:
4.0
5bojA-3go1L:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h87 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Mycobacterium
tuberculosis)
PF01402
(RHH_1)
4 LEU C  24
ALA C  22
LEU C  26
SER C  27
GOL  C  74 (-4.3A)
None
None
None
1.03A 5bojA-3h87C:
undetectable
5bojA-3h87C:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvw DIGUANYLATE-CYCLASE
(DGC)


(Pseudomonas
aeruginosa)
PF00990
(GGDEF)
4 LEU A 267
LEU A 264
SER A 261
THR A 259
None
1.06A 5bojA-3hvwA:
undetectable
5bojA-3hvwA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig3 PLXNA3 PROTEIN

(Mus musculus)
PF08337
(Plexin_cytopl)
4 LYS A1780
ALA A1779
LEU A1777
SER A1773
None
1.01A 5bojA-3ig3A:
undetectable
5bojA-3ig3A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwk AMINOALDEHYDE
DEHYDROGENASE


(Pisum sativum)
PF00171
(Aldedh)
4 LEU A 184
LEU A 157
SER A 235
THR A 237
None
0.74A 5bojA-3iwkA:
undetectable
5bojA-3iwkA:
13.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iwu 5-HYDROXYISOURATE
HYDROLASE


(Danio rerio)
PF00576
(Transthyretin)
4 LEU A  14
LEU A 107
SER A 114
THR A 116
None
0.92A 5bojA-3iwuA:
19.7
5bojA-3iwuA:
32.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcf DIPHOSPHOINOSITOL
POLYPHOSPHATE
PHOSPHOHYDROLASE
3-ALPHA


(Homo sapiens)
PF00293
(NUDIX)
4 LEU A  23
ALA A  21
LEU A  80
THR A  93
None
1.01A 5bojA-3mcfA:
undetectable
5bojA-3mcfA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mj8 STIMULATORY HAMSTER
ANTIBODY HL4E10 FAB
LIGHT CHAIN


(Cricetulus
migratorius)
no annotation 4 LEU L 132
ALA L 130
LEU L 179
THR L 182
None
1.07A 5bojA-3mj8L:
undetectable
5bojA-3mj8L:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mlu HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 2557 FAB
LIGHT CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 LEU L 136
ALA L 134
LEU L 182
THR L 185
None
1.06A 5bojA-3mluL:
3.8
5bojA-3mluL:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE


(Bartonella
henselae)
PF00274
(Glycolytic)
4 LYS A 223
ALA A 261
LEU A  12
THR A 290
2FP  A 350 (-2.2A)
None
None
None
1.06A 5bojA-3mmtA:
undetectable
5bojA-3mmtA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n4x MONOPOLIN COMPLEX
SUBUNIT CSM1


(Saccharomyces
cerevisiae)
PF12539
(Csm1)
4 LYS A 119
ALA A 135
SER A 162
THR A 160
None
0.91A 5bojA-3n4xA:
undetectable
5bojA-3n4xA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oee ATP SYNTHASE SUBUNIT
ALPHA


(Saccharomyces
cerevisiae)
PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N)
4 LEU A 481
ALA A 497
LEU A 495
SER A 492
None
1.01A 5bojA-3oeeA:
undetectable
5bojA-3oeeA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqj BIOFILM
GROWTH-ASSOCIATED
REPRESSOR


(Xylella
fastidiosa)
PF12840
(HTH_20)
4 LEU A  72
LEU A  69
SER A  66
THR A  64
None
0.98A 5bojA-3pqjA:
undetectable
5bojA-3pqjA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia)
PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
4 LEU B 280
LEU B 264
SER B 317
THR B 319
None
0.63A 5bojA-3prxB:
3.2
5bojA-3prxB:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbd 3-DEHYDROQUINATE
SYNTHASE


(Mycobacterium
tuberculosis)
PF01761
(DHQ_synthase)
4 LEU A  48
ALA A 109
LEU A 104
THR A 110
None
0.96A 5bojA-3qbdA:
undetectable
5bojA-3qbdA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 LEU K 135
ALA K 133
LEU K 181
THR K 184
None
1.05A 5bojA-3ri5K:
3.8
5bojA-3ri5K:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sag EXOSOME COMPONENT 10

(Homo sapiens)
PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1)
4 LEU A 396
ALA A 392
LEU A 398
THR A 389
LEU  A 396 ( 0.6A)
ALA  A 392 ( 0.0A)
LEU  A 398 ( 0.6A)
THR  A 389 ( 0.8A)
0.95A 5bojA-3sagA:
undetectable
5bojA-3sagA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY


(Sphaerobacter
thermophilus)
PF01380
(SIS)
4 LEU A 215
ALA A 233
LEU A 231
THR A 115
None
1.05A 5bojA-3shoA:
undetectable
5bojA-3shoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swl CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 1


(Homo sapiens)
PF13409
(GST_N_2)
PF13410
(GST_C_2)
4 LEU A 180
ALA A 176
LEU A 181
THR A 174
None
1.06A 5bojA-3swlA:
undetectable
5bojA-3swlA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2n ANTIBODY, FAB
FRAGMENT, LIGHT
CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 LEU L 133
ALA L 131
LEU L 179
THR L 182
None
1.07A 5bojA-3t2nL:
3.8
5bojA-3t2nL:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t38 ARSENATE REDUCTASE

(Corynebacterium
glutamicum)
PF01451
(LMWPc)
4 LEU A  58
ALA A  49
SER A  44
THR A  48
None
0.89A 5bojA-3t38A:
undetectable
5bojA-3t38A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6s CERJ

(Streptomyces
tendae)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
4 LEU A 240
ALA A 243
LEU A 239
THR A 187
None
0.96A 5bojA-3t6sA:
undetectable
5bojA-3t6sA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk2 PANTOTHENATE
SYNTHETASE


(Burkholderia
thailandensis)
PF02569
(Pantoate_ligase)
4 LEU A 268
ALA A 266
LEU A 273
THR A 264
None
0.88A 5bojA-3uk2A:
undetectable
5bojA-3uk2A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1


(Homo sapiens)
PF00079
(Serpin)
4 LYS A 323
ALA A 168
SER A  92
THR A  94
None
0.86A 5bojA-3ut3A:
undetectable
5bojA-3ut3A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxj NADPH-DEPENDENT
7-CYANO-7-DEAZAGUANI
NE REDUCTASE


(Vibrio cholerae)
PF14489
(QueF)
PF14819
(QueF_N)
4 LYS A  96
LEU A 100
LEU A  35
SER A  34
NAP  A 291 (-3.1A)
None
None
None
0.99A 5bojA-3uxjA:
undetectable
5bojA-3uxjA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II


(Ascaris suum)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
4 LEU A 552
LEU A 549
SER A 546
THR A 544
None
1.07A 5bojA-3vrbA:
undetectable
5bojA-3vrbA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
4 LEU A 249
LEU A 264
SER A 265
THR A 262
None
1.08A 5bojA-3wdjA:
undetectable
5bojA-3wdjA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7k ALDOS-2-ULOSE
DEHYDRATASE


(Phanerochaete
chrysosporium)
no annotation 4 ALA A 893
LEU A 891
SER A 867
THR A 852
None
0.92A 5bojA-4a7kA:
undetectable
5bojA-4a7kA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b5m PUTATIVE
EXODEOXYRIBONUCLEASE


(Neisseria
meningitidis)
PF03372
(Exo_endo_phos)
4 LYS A 240
ALA A 248
LEU A 250
SER A   6
None
0.96A 5bojA-4b5mA:
undetectable
5bojA-4b5mA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1


(Saccharomyces
cerevisiae)
PF04054
(Not1)
4 LEU A1741
LEU A1738
SER A1735
THR A1733
None
1.06A 5bojA-4by6A:
undetectable
5bojA-4by6A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci6 PROTEIN KINASE YOPO

(Yersinia
enterocolitica)
PF00069
(Pkinase)
PF09632
(Rac1)
4 LEU B 608
LEU B 605
SER B 602
THR B 600
None
1.03A 5bojA-4ci6B:
undetectable
5bojA-4ci6B:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ctd OUTER MEMBRANE
PROTEIN G


(Escherichia
coli)
PF09381
(Porin_OmpG)
4 LEU A 167
ALA A 195
LEU A 197
THR A 210
None
None
None
CL  A1274 (-4.2A)
0.63A 5bojA-4ctdA:
undetectable
5bojA-4ctdA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxf RNA POLYMERASE SIGMA
FACTOR CNRH


(Cupriavidus
metallidurans)
PF04542
(Sigma70_r2)
PF08281
(Sigma70_r4_2)
4 LEU A 163
ALA A 161
LEU A 165
SER A 166
None
None
SO4  A1192 (-4.5A)
None
1.07A 5bojA-4cxfA:
undetectable
5bojA-4cxfA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9i DIAMINOPROPIONATE
AMMONIA-LYASE


(Escherichia
coli)
PF00291
(PALP)
4 LYS A  61
LEU A  63
LEU A 372
THR A 225
None
1.07A 5bojA-4d9iA:
undetectable
5bojA-4d9iA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di4 TATP(T) (TP0957)

(Treponema
pallidum)
PF03480
(DctP)
4 LEU B 187
LEU B 190
SER B 195
THR B 157
None
1.04A 5bojA-4di4B:
undetectable
5bojA-4di4B:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwg TTC1975 PEPTIDASE

(Meiothermus
taiwanensis)
PF05362
(Lon_C)
PF13654
(AAA_32)
4 LEU A 592
ALA A 677
LEU A 681
THR A 676
None
1.05A 5bojA-4fwgA:
undetectable
5bojA-4fwgA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE


(Trypanosoma
brucei)
PF00067
(p450)
4 LYS A 421
ALA A 417
LEU A  91
SER A  87
None
1.05A 5bojA-4g3jA:
undetectable
5bojA-4g3jA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3w TRANSCRIPTIONAL
REGULATOR NLH1


(Aquifex
aeolicus)
PF01590
(GAF)
4 LEU A 148
ALA A 116
LEU A 129
THR A  77
None
1.07A 5bojA-4g3wA:
undetectable
5bojA-4g3wA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfo BIOGENIC
AMINE-BINDING
PROTEIN


(Rhodnius
prolixus)
PF02087
(Nitrophorin)
4 LEU A 187
LEU A  46
SER A  22
THR A  20
None
1.07A 5bojA-4hfoA:
undetectable
5bojA-4hfoA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE


(Solanum
lycopersicum)
PF00171
(Aldedh)
4 LEU A 184
LEU A 157
SER A 235
THR A 237
None
None
None
NAD  A 601 (-4.2A)
0.76A 5bojA-4i8qA:
undetectable
5bojA-4i8qA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ija XYLR PROTEIN

(Staphylococcus
aureus)
PF00480
(ROK)
PF01047
(MarR)
4 LEU A  41
LEU A  38
SER A  35
THR A  33
None
1.02A 5bojA-4ijaA:
undetectable
5bojA-4ijaA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jy4 PGT121 LIGHT CHAIN

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 LEU A 133
ALA A 131
LEU A 179
THR A 182
None
1.02A 5bojA-4jy4A:
undetectable
5bojA-4jy4A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1y SALIVARY NITROPHORIN

(Cimex
lectularius)
no annotation 4 LEU A  86
ALA A  41
SER A  13
THR A  11
None
0.75A 5bojA-4l1yA:
undetectable
5bojA-4l1yA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llu LIGHT CHAIN CLAMBDA

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 LEU B 133
ALA B 131
LEU B 179
THR B 182
None
1.06A 5bojA-4lluB:
3.9
5bojA-4lluB:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsu LIGHT CHAIN OF
ANTIBODY VRC-PG20


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 LEU L 132
ALA L 130
LEU L 178
THR L 181
None
1.02A 5bojA-4lsuL:
undetectable
5bojA-4lsuL:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8)
4 LEU A 447
LEU A 452
SER A 453
THR A 455
None
0.98A 5bojA-4m7eA:
undetectable
5bojA-4m7eA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A


(Streptococcus
pneumoniae)
PF12708
(Pectate_lyase_3)
PF13229
(Beta_helix)
4 LYS A 426
LEU A 424
ALA A 470
THR A 503
None
CA  A 702 ( 4.5A)
None
None
0.79A 5bojA-4mr0A:
undetectable
5bojA-4mr0A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2x DL-2-HALOACID
DEHALOGENASE


(Methylobacterium
sp. CPA1)
PF10778
(DehI)
4 LEU A 179
ALA A 171
LEU A   7
SER A   5
None
1.05A 5bojA-4n2xA:
undetectable
5bojA-4n2xA:
16.50