SIMILAR PATTERNS OF AMINO ACIDS FOR 5B8I_C_FK5C201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		4 SER A 728
PRO A 727
PHE A 729
GLU A 725
 None
 1.23A 5b8iA-1d0nA:
undetectable		 5b8iA-1d0nA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2k CHITINASE 1

(Coccidioides
immitis) 		PF00704
(Glyco_hydro_18) 		4 TRP A 245
SER A 242
PRO A 266
PHE A 241
 None
 1.21A 5b8iA-1d2kA:
0.2		 5b8iA-1d2kA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7w MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		4 SER C 368
PRO C 244
PHE C 366
GLU C 242
 None
None
None
HEM  A 605 (-2.1A)
 1.27A 5b8iA-1d7wC:
undetectable		 5b8iA-1d7wC:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqn DNA PRIMASE

(Escherichia
coli) 		PF08275
(Toprim_N)
PF10410
(DnaB_bind)
PF13155
(Toprim_2) 		4 LEU A 407
SER A 369
PRO A 367
PHE A 371
 None
 1.20A 5b8iA-1eqnA:
0.1		 5b8iA-1eqnA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imj CCG1-INTERACTING
FACTOR B

(Homo sapiens) 		PF12697
(Abhydrolase_6) 		4 LEU A  69
SER A 117
PRO A 119
PHE A 120
 None
 0.78A 5b8iA-1imjA:
undetectable		 5b8iA-1imjA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 SER A 458
PRO A 461
PHE A 460
GLU A 463
 None
None
MLY  A 558 ( 4.4A)
MLY  A 558 ( 3.0A)
 1.19A 5b8iA-1iv8A:
0.1		 5b8iA-1iv8A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j93 UROPORPHYRINOGEN
DECARBOXYLASE

(Nicotiana
tabacum) 		PF01208
(URO-D) 		4 LEU A 258
SER A 228
PRO A 230
PHE A 227
 None
 1.15A 5b8iA-1j93A:
undetectable		 5b8iA-1j93A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzk HEROIN ESTERASE

(Rhodococcus sp.) 		PF07859
(Abhydrolase_3) 		4 SER A  98
PRO A 100
PHE A 101
GLU A 104
 None
 1.18A 5b8iA-1lzkA:
undetectable		 5b8iA-1lzkA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q32 TYROSYL-DNA
PHOSPHODIESTERASE

(Saccharomyces
cerevisiae) 		PF06087
(Tyr-DNA_phospho) 		4 LEU A 492
SER A 266
PRO A 232
PHE A 233
 None
 1.14A 5b8iA-1q32A:
undetectable		 5b8iA-1q32A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1

(Canis lupus) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 LEU A 264
SER A 152
PRO A 177
GLU A 179
 None
 1.28A 5b8iA-1rp1A:
undetectable		 5b8iA-1rp1A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql ETHYLBENZENE
DIOXYGENASE SMALL
SUBUNIT
IRON-SULFUR PROTEIN
LARGE SUBUNIT OF
CUMENE DIOXYGENASE

(Pseudomonas
fluorescens) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
PF00866
(Ring_hydroxyl_B) 		4 LEU A 254
SER A 247
PRO A 249
GLU B  85
 None
 1.22A 5b8iA-1wqlA:
undetectable		 5b8iA-1wqlA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwr TRNA ADENOSINE
DEAMINASE TADA

(Aquifex
aeolicus) 		PF14437
(MafB19-deam) 		4 LEU A 139
SER A 100
PRO A 131
PHE A  99
 None
 1.30A 5b8iA-1wwrA:
undetectable		 5b8iA-1wwrA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5e THIOREDOXIN DOMAIN
CONTAINING PROTEIN 1

(Homo sapiens) 		PF00085
(Thioredoxin) 		4 LEU A  21
SER A 121
PRO A 123
PHE A 120
 None
 1.22A 5b8iA-1x5eA:
undetectable		 5b8iA-1x5eA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Helicobacter
pylori) 		PF02540
(NAD_synthase) 		4 LEU A 224
PRO A 205
PHE A 160
GLU A 163
 None
 1.28A 5b8iA-1xngA:
undetectable		 5b8iA-1xngA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii) 		PF09043
(Lys-AminoMut_A) 		4 LEU A   5
PRO A 365
PHE A 364
GLU A 321
 None
 1.02A 5b8iA-1xrsA:
undetectable		 5b8iA-1xrsA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE

(Spinacia
oleracea) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 LEU I 144
SER I 295
PRO I 251
GLU I 311
 None
None
NDP  I 600 (-4.7A)
None
 1.30A 5b8iA-1yveI:
undetectable		 5b8iA-1yveI:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aj7 HYPOTHETICAL PROTEIN
BH3618

(Bacillus
halodurans) 		PF02623
(FliW) 		4 LEU A 139
SER A  66
PRO A  69
PHE A  65
 None
FMT  A 157 (-3.6A)
None
None
 0.99A 5b8iA-2aj7A:
undetectable		 5b8iA-2aj7A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES

(Bacillus cereus) 		PF03486
(HI0933_like) 		4 LEU A  41
PRO A 104
PHE A 103
GLU A  97
 None
 1.26A 5b8iA-2i0zA:
undetectable		 5b8iA-2i0zA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqt FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS 1

(Porphyromonas
gingivalis) 		PF00274
(Glycolytic) 		4 LEU A 107
PRO A 119
PHE A 120
GLU A 122
 None
 1.25A 5b8iA-2iqtA:
undetectable		 5b8iA-2iqtA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN

(Escherichia
coli) 		PF03349
(Toluene_X) 		4 LEU A  68
SER A 116
PHE A 158
GLU A 156
 None
 1.27A 5b8iA-2r8aA:
undetectable		 5b8iA-2r8aA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA

(Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 SER A 169
PRO A 208
PHE A 210
GLU A 204
 None
 1.30A 5b8iA-2v4jA:
undetectable		 5b8iA-2v4jA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE

(Lactococcus
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 359
TRP A 360
SER A 380
PHE A 381
 LEU  A 359 ( 0.5A)
TRP  A 360 ( 0.5A)
SER  A 380 ( 0.0A)
PHE  A 381 ( 1.3A)
 1.29A 5b8iA-2vbfA:
undetectable		 5b8iA-2vbfA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpz LEUKOTRIENE A-4
HYDROLASE

(Saccharomyces
cerevisiae) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		4 LEU A 394
SER A 408
PRO A 404
PHE A 407
 None
 1.27A 5b8iA-2xpzA:
undetectable		 5b8iA-2xpzA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0v SH3-CONTAINING
GRB2-LIKE PROTEIN 3

(Homo sapiens) 		PF03114
(BAR) 		4 LEU A 135
SER A 177
PHE A 179
GLU A 183
 None
 1.23A 5b8iA-2z0vA:
undetectable		 5b8iA-2z0vA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axi OLIGO-1,6-GLUCOSIDAS
E IMA1

(Saccharomyces
cerevisiae) 		PF00128
(Alpha-amylase) 		4 LEU A 226
PRO A 249
PHE A 254
GLU A 253
 None
 1.28A 5b8iA-3axiA:
undetectable		 5b8iA-3axiA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b89 16S RRNA METHYLASE

(Escherichia
coli) 		PF07091
(FmrO) 		4 LEU A 136
PRO A 142
PHE A 143
GLU A 146
 None
 1.22A 5b8iA-3b89A:
undetectable		 5b8iA-3b89A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8i PA4872 OXALOACETATE
DECARBOXYLASE

(Pseudomonas
aeruginosa) 		PF13714
(PEP_mutase) 		4 LEU A 260
PRO A 272
PHE A 271
GLU A 274
 None
 1.29A 5b8iA-3b8iA:
undetectable		 5b8iA-3b8iA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddl XANTHORHODOPSIN

(Salinibacter
ruber) 		PF01036
(Bac_rhodopsin) 		4 LEU A 196
TRP A 200
PRO A 204
GLU A 141
 None
RET  A1301 (-3.9A)
RET  A1301 ( 4.2A)
RET  A1301 ( 3.8A)
 1.21A 5b8iA-3ddlA:
undetectable		 5b8iA-3ddlA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)

(Oryza sativa) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 LEU A 144
SER A 295
PRO A 251
GLU A 311
 None
 1.26A 5b8iA-3fr8A:
undetectable		 5b8iA-3fr8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gby UNCHARACTERIZED
PROTEIN CT1051

(Chlorobaculum
tepidum) 		PF00571
(CBS) 		4 SER A   5
PRO A  80
PHE A   4
GLU A  82
 None
EPE  A 127 (-3.9A)
None
EPE  A 127 (-4.5A)
 1.27A 5b8iA-3gbyA:
undetectable		 5b8iA-3gbyA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxa OUTER MEMBRANE
LIPOPROTEIN GNA1946

(Neisseria
meningitidis) 		PF03180
(Lipoprotein_9) 		4 SER A 152
PRO A 151
PHE A 154
GLU A 194
 None
 1.28A 5b8iA-3gxaA:
undetectable		 5b8iA-3gxaA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ir1 OUTER MEMBRANE
LIPOPROTEIN GNA1946

(Neisseria
meningitidis) 		PF03180
(Lipoprotein_9) 		4 SER A 152
PRO A 151
PHE A 154
GLU A 194
 None
 1.28A 5b8iA-3ir1A:
undetectable		 5b8iA-3ir1A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE

(Staphylococcus
aureus) 		PF01791
(DeoC) 		4 SER A 195
PRO A 197
PHE A 199
GLU A 147
 None
 1.29A 5b8iA-3kaoA:
undetectable		 5b8iA-3kaoA:
21.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		5 LEU A 343
TRP A 352
SER A 353
PHE A 356
GLU A 359
 None
 0.83A 5b8iA-3ll8A:
56.7		 5b8iA-3ll8A:
73.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		5 LEU A 343
TRP A 352
SER A 353
PRO A 355
PHE A 356
 None
 0.52A 5b8iA-3ll8A:
56.7		 5b8iA-3ll8A:
73.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmb UNCHARACTERIZED
PROTEIN

(Oleispira
antarctica) 		PF09500
(YiiD_C) 		4 LEU A  61
SER A 152
PRO A 151
GLU A 146
 None
 1.20A 5b8iA-3lmbA:
undetectable		 5b8iA-3lmbA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		4 LEU A 326
SER A 350
PRO A 354
PHE A 353
 None
 0.95A 5b8iA-3nksA:
undetectable		 5b8iA-3nksA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orj SUGAR-BINDING
PROTEIN

(Bacteroides
ovatus) 		no annotation 4 TRP A 355
SER A 329
PHE A 331
GLU A 412
 None
 1.24A 5b8iA-3orjA:
undetectable		 5b8iA-3orjA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf2 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		4 LEU A 256
TRP A 230
PHE A 231
GLU A 332
 None
 1.12A 5b8iA-3pf2A:
undetectable		 5b8iA-3pf2A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9j MEMBER OF DUF4221
FAMILY

(Bacteroides
vulgatus) 		PF13970
(DUF4221) 		4 LEU A 197
SER A 112
PRO A 113
GLU A  61
 None
FMT  A 408 (-4.3A)
FMT  A 408 ( 4.4A)
GOL  A 418 (-3.7A)
 1.29A 5b8iA-3s9jA:
undetectable		 5b8iA-3s9jA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shq UBLCP1

(Drosophila
melanogaster) 		PF00240
(ubiquitin)
PF03031
(NIF) 		4 LEU A 306
SER A 266
PRO A 264
PHE A 260
 None
 1.30A 5b8iA-3shqA:
undetectable		 5b8iA-3shqA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vqr PUTATIVE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF01266
(DAO) 		4 LEU A 141
SER A 333
PRO A 337
PHE A 339
 None
 1.16A 5b8iA-3vqrA:
undetectable		 5b8iA-3vqrA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0k DNA DAMAGE-BINDING
PROTEIN 2

(Danio rerio) 		PF00400
(WD40) 		4 LEU D 450
SER D 144
PRO D 145
PHE D 447
 None
 1.17A 5b8iA-4a0kD:
undetectable		 5b8iA-4a0kD:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 LEU D 217
SER D 182
PHE D 181
GLU D 247
 None
 0.93A 5b8iA-4b2qD:
undetectable		 5b8iA-4b2qD:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsf PENICILLIN-BINDING
PROTEIN 3

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 LEU A 235
SER A 538
PRO A 540
PHE A 542
 None
 1.17A 5b8iA-4fsfA:
undetectable		 5b8iA-4fsfA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fyp VEGETATIVE STORAGE
PROTEIN 1

(Arabidopsis
thaliana) 		PF03767
(Acid_phosphat_B) 		4 LEU A 164
SER A 132
PRO A 134
GLU A 159
 None
 1.28A 5b8iA-4fypA:
undetectable		 5b8iA-4fypA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 LEU A 214
PRO A 182
PHE A 185
GLU A 184
 None
None
None
FUC  A 505 (-3.5A)
 1.23A 5b8iA-4hq1A:
undetectable		 5b8iA-4hq1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifr 2-AMINO-3-CARBOXYMUC
ONATE 6-SEMIALDEHYDE
DECARBOXYLASE

(Pseudomonas
fluorescens) 		PF04909
(Amidohydro_2) 		5 LEU A  32
TRP A  58
PRO A  60
PHE A  62
GLU A  65
 None
 1.14A 5b8iA-4ifrA:
undetectable		 5b8iA-4ifrA:
21.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4il1 CALMODULIN,
CALCINEURIN SUBUNIT
B TYPE 1,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Rattus
norvegicus) 		PF00149
(Metallophos)
PF13499
(EF-hand_7) 		6 LEU A 676
TRP A 685
SER A 686
PRO A 688
PHE A 689
GLU A 692
 None
 0.75A 5b8iA-4il1A:
52.8		 5b8iA-4il1A:
40.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4it7 CPI

(Ascaris
lumbricoides) 		PF00031
(Cystatin) 		4 LEU A  21
PRO A  97
PHE A 101
GLU A  99
 None
 1.14A 5b8iA-4it7A:
undetectable		 5b8iA-4it7A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjj CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Thermobifida
fusca) 		PF02011
(Glyco_hydro_48) 		4 LEU A 604
SER A 548
PRO A 547
GLU A  40
 None
ZN  A 735 (-3.9A)
None
CBK  A 702 ( 3.4A)
 1.17A 5b8iA-4jjjA:
undetectable		 5b8iA-4jjjA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ly4 PEPTIDOGLYCAN
DEACETYLASE

(Helicobacter
pylori) 		PF01522
(Polysacc_deac_1) 		4 LEU A 111
PRO A  70
PHE A  69
GLU A  40
 None
 1.28A 5b8iA-4ly4A:
undetectable		 5b8iA-4ly4A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mg4 PHOSPHONOMUTASE

(Burkholderia
cenocepacia) 		PF13714
(PEP_mutase) 		4 LEU A 113
SER A 116
PRO A 118
PHE A 117
 None
 1.30A 5b8iA-4mg4A:
undetectable		 5b8iA-4mg4A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnp N-ACETYLNEURAMINATE-
BINDING PROTEIN

(Fusobacterium
nucleatum) 		PF03480
(DctP) 		4 LEU A 139
PRO A 282
PHE A 283
GLU A 286
 None
 1.06A 5b8iA-4mnpA:
undetectable		 5b8iA-4mnpA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nkq GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA

(Homo sapiens) 		PF09240
(IL6Ra-bind) 		4 TRP B 287
SER B 288
PHE B 199
GLU B 197
 None
 1.27A 5b8iA-4nkqB:
undetectable		 5b8iA-4nkqB:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		6 LEU A 352
TRP A 361
SER A 362
PRO A 364
PHE A 365
GLU A 368
 None
 0.72A 5b8iA-4oraA:
55.7		 5b8iA-4oraA:
52.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4orb SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Mus musculus) 		PF00149
(Metallophos) 		6 LEU A 343
TRP A 352
SER A 353
PRO A 355
PHE A 356
GLU A 359
 None
 0.64A 5b8iA-4orbA:
55.9		 5b8iA-4orbA:
69.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozd 14.4 KDA SALIVARY
PROTEIN

(Phlebotomus
duboscqi) 		PF01395
(PBP_GOBP) 		4 LEU A  21
SER A   4
PRO A   3
GLU A   1
 None
 1.27A 5b8iA-4ozdA:
undetectable		 5b8iA-4ozdA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxn UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00171
(Aldedh) 		4 LEU A 172
TRP A 188
SER A 221
GLU A  53
 None
 1.29A 5b8iA-4pxnA:
undetectable		 5b8iA-4pxnA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q88 UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF07470
(Glyco_hydro_88) 		4 TRP A  81
SER A  51
PHE A  52
GLU A 104
 None
 1.23A 5b8iA-4q88A:
undetectable		 5b8iA-4q88A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r89 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF08774
(VRR_NUC) 		4 LEU A 262
SER A 286
PRO A 288
GLU A 323
 None
 1.21A 5b8iA-4r89A:
undetectable		 5b8iA-4r89A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY

(Trichormus
variabilis) 		PF13458
(Peripla_BP_6) 		4 LEU A 380
SER A 170
PRO A 172
GLU A 208
 None
 1.27A 5b8iA-4rdcA:
undetectable		 5b8iA-4rdcA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA

(Homo sapiens) 		PF09240
(IL6Ra-bind) 		4 TRP B 287
SER B 288
PHE B 199
GLU B 197
 None
 1.27A 5b8iA-4rs1B:
undetectable		 5b8iA-4rs1B:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us5 LUCIFERASE-LIKE
MONOOXYGENASE

(Streptomyces
bottropensis) 		PF00296
(Bac_luciferase) 		4 LEU A 219
PRO A 280
PHE A 277
GLU A 275
 None
 1.20A 5b8iA-4us5A:
undetectable		 5b8iA-4us5A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us5 LUCIFERASE-LIKE
MONOOXYGENASE

(Streptomyces
bottropensis) 		PF00296
(Bac_luciferase) 		4 LEU A 331
SER A   4
PHE A  39
GLU A   7
 None
None
None
NA  A1335 (-3.2A)
 1.23A 5b8iA-4us5A:
undetectable		 5b8iA-4us5A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1r ALPHA-1,6-MANNANASE

(Bacteroides
thetaiotaomicron) 		PF03663
(Glyco_hydro_76) 		4 LEU A  87
SER A 377
PHE A 376
GLU A 359
 None
 1.13A 5b8iA-4v1rA:
undetectable		 5b8iA-4v1rA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrl MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF00047
(ig) 		4 LEU A 148
SER A 139
PHE A 156
GLU A 135
 None
 1.07A 5b8iA-4wrlA:
undetectable		 5b8iA-4wrlA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrm MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF00047
(ig)
PF13927
(Ig_3) 		4 LEU A 148
SER A 139
PHE A 156
GLU A 135
 None
 1.08A 5b8iA-4wrmA:
undetectable		 5b8iA-4wrmA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xru HEN1

(Capnocytophaga
gingivalis) 		no annotation 4 LEU C  15
SER C 160
PRO C 113
GLU C 157
 None
 1.29A 5b8iA-4xruC:
undetectable		 5b8iA-4xruC:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 LEU A 964
PRO A1263
PHE A1005
GLU A1261
 None
None
None
URC  A3007 (-2.9A)
 1.28A 5b8iA-4yswA:
undetectable		 5b8iA-4yswA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zb6 PCURE2P4

(Phanerochaete
chrysosporium) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A 151
SER A 172
PHE A 171
GLU A  28
 None
 1.10A 5b8iA-4zb6A:
undetectable		 5b8iA-4zb6A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zb8 PCURE2P6

(Phanerochaete
chrysosporium) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A 150
SER A 171
PHE A 170
GLU A  27
 None
 1.14A 5b8iA-4zb8A:
undetectable		 5b8iA-4zb8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		4 SER A 151
PRO A 183
PHE A 181
GLU A 134
 None
 1.13A 5b8iA-5aeeA:
undetectable		 5b8iA-5aeeA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		4 LEU A 345
SER A 219
PRO A 223
PHE A 222
 None
 1.30A 5b8iA-5dqfA:
undetectable		 5b8iA-5dqfA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1

(Homo sapiens) 		PF02137
(A_deamin) 		4 LEU A 323
SER A 543
PRO A 579
PHE A 542
 None
 1.10A 5b8iA-5ed1A:
undetectable		 5b8iA-5ed1A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsi PUTATIVE
DECARBOXYLASE

(Lactobacillus
brevis) 		PF00282
(Pyridoxal_deC) 		4 LEU A 289
SER A 174
PRO A 176
PHE A 177
 None
 1.28A 5b8iA-5hsiA:
undetectable		 5b8iA-5hsiA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN

(uncultured
marine
bacterium) 		PF03480
(DctP) 		4 LEU A 140
TRP A  48
SER A  49
PRO A  47
 None
None
None
PEG  A 402 (-3.4A)
 1.19A 5b8iA-5i5pA:
undetectable		 5b8iA-5i5pA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 LEU B 850
PRO B1089
PHE B1087
GLU B1070
 None
 1.29A 5b8iA-5ip9B:
undetectable		 5b8iA-5ip9B:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j62 PUTATIVE REDUCTASE

(Clostridioides
difficile) 		PF00881
(Nitroreductase) 		4 LEU A 114
SER A  99
PRO A 188
PHE A  97
 None
 1.12A 5b8iA-5j62A:
undetectable		 5b8iA-5j62A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5joe TITIN

(Homo sapiens) 		PF07679
(I-set) 		4 LEU A  34
TRP A  36
PRO A  45
PHE A  49
 None
 0.88A 5b8iA-5joeA:
undetectable		 5b8iA-5joeA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqk PEPTIDASE, PUTATIVE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		4 LEU A 354
SER A 369
PHE A 388
GLU A 414
 None
 1.21A 5b8iA-5jqkA:
undetectable		 5b8iA-5jqkA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8f ACETYL-COENZYME A
SYNTHETASE

(Cryptococcus
neoformans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 LEU A 102
SER A 302
PRO A 283
PHE A 285
 None
 1.23A 5b8iA-5k8fA:
undetectable		 5b8iA-5k8fA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m30 TYPE VI SECRETION
PROTEIN

(Escherichia
coli) 		PF05936
(T6SS_VasE) 		4 LEU A  54
PRO A 182
PHE A 184
GLU A 296
 None
 0.83A 5b8iA-5m30A:
undetectable		 5b8iA-5m30A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwn TYPE VI SECRETION
PROTEIN

(Escherichia
coli) 		PF05936
(T6SS_VasE) 		4 LEU A  54
PRO A 182
PHE A 184
GLU A 296
 None
 0.91A 5b8iA-5mwnA:
undetectable		 5b8iA-5mwnA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okl AFAMIN

(Homo sapiens) 		no annotation 4 LEU A 349
SER A 223
PRO A 227
PHE A 226
 None
 1.19A 5b8iA-5oklA:
undetectable		 5b8iA-5oklA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL

(Aplysia
californica) 		PF00520
(Ion_trans)
PF03493
(BK_channel_a) 		4 LEU A 763
SER A 486
PRO A 490
PHE A 492
 None
 1.19A 5b8iA-5tj6A:
1.5		 5b8iA-5tj6A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7z ACID CERAMIDASE

(Homo sapiens) 		no annotation 4 LEU B 276
TRP B 248
PRO A 109
GLU A 115
 None
 1.10A 5b8iA-5u7zB:
undetectable		 5b8iA-5u7zB:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8e ARGININE KINASE

(Polybetes
pythagoricus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 LEU A 275
SER A 260
PHE A 259
GLU A 254
 None
 1.30A 5b8iA-5u8eA:
undetectable		 5b8iA-5u8eA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42

(Saccharomyces
cerevisiae) 		no annotation 4 SER D 527
PRO D 530
PHE D 529
GLU D 532
 None
 0.95A 5b8iA-5uz5D:
undetectable		 5b8iA-5uz5D:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v3g PR DOMAIN ZINC
FINGER PROTEIN 9

(Homo sapiens) 		no annotation 4 TRP D 814
SER D 813
PRO D 802
PHE D 812
 None
 1.25A 5b8iA-5v3gD:
undetectable		 5b8iA-5v3gD:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7p OXAC

(Penicillium
oxalicum) 		no annotation 4 LEU A 140
SER A 136
PRO A 121
PHE A 135
 None
 1.30A 5b8iA-5w7pA:
undetectable		 5b8iA-5w7pA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w81 CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Danio rerio) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		4 LEU A 241
SER A 309
PHE A 312
GLU A 932
 None
 1.00A 5b8iA-5w81A:
undetectable		 5b8iA-5w81A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydf PARAFIBROMIN

(Homo sapiens) 		no annotation 4 LEU A  57
SER A  31
PHE A  30
GLU A  29
 None
 1.18A 5b8iA-5ydfA:
undetectable		 5b8iA-5ydfA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yeu -

(-) 		no annotation 4 LEU A 283
SER A 242
PHE A 243
GLU A 363
 None
 1.15A 5b8iA-5yeuA:
undetectable		 5b8iA-5yeuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Moorella
thermoacetica) 		no annotation 4 SER A 796
PRO A 790
PHE A 788
GLU A 727
 None
 1.27A 5b8iA-6cipA:
undetectable		 5b8iA-6cipA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cvz E3 UBIQUITIN-PROTEIN
LIGASE RFWD3

(Homo sapiens) 		no annotation 5 LEU A 588
SER A 616
PRO A 628
PHE A 617
GLU A 619
 None
 1.49A 5b8iA-6cvzA:
undetectable		 5b8iA-6cvzA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5z 24-STEROL
C-METHYLTRANSFERASE
UPF0434 FAMILY
PROTEIN

(Haloferax
volcanii) 		no annotation 4 LEU C  54
SER A  71
PHE A   7
GLU A   6
 None
None
SAH  A 301 (-3.5A)
None
 1.27A 5b8iA-6f5zC:
undetectable		 5b8iA-6f5zC:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Mus musculus) 		no annotation 4 LEU M 457
SER M  62
PRO M  64
PHE M 110
 None
None
3PE  M 503 ( 4.6A)
None
 1.14A 5b8iA-6g2jM:
undetectable		 5b8iA-6g2jM:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0t PYRUVATE KINASE

(Escherichia
coli) 		PF00224
(PK)
PF02887
(PK_C) 		4 LEU A  24
MET A  54
VAL A  53
ASN A  52
 None
 1.42A 5b8iB-1e0tA:
undetectable		 5b8iB-1e0tA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5h FORMIMINOTETRAHYDROF
OLATE CYCLODEAMINASE

(Thermotoga
maritima) 		PF04961
(FTCD_C) 		4 LEU A  38
MET A  41
VAL A  42
ASN A 131
 None
 1.39A 5b8iB-1o5hA:
undetectable		 5b8iB-1o5hA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p99 HYPOTHETICAL PROTEIN
PG110

(Staphylococcus
aureus) 		PF03180
(Lipoprotein_9) 		4 LEU A 113
MET A  89
VAL A 242
ASN A 243
 None
 0.92A 5b8iB-1p99A:
0.0		 5b8iB-1p99A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pch PHOSPHOCARRIER
PROTEIN

(Mycoplasma
capricolum) 		PF00381
(PTS-HPr) 		4 LEU A  14
MET A  51
VAL A  50
ASN A  49
 None
 1.38A 5b8iB-1pchA:
undetectable		 5b8iB-1pchA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5r PROTEASOME BETA-TYPE
SUBUNIT 1

(Rhodococcus
erythropolis) 		PF00227
(Proteasome) 		4 LEU H  83
MET H  86
VAL H  87
ASN H  90
 None
 1.34A 5b8iB-1q5rH:
0.3		 5b8iB-1q5rH:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		4 LEU A 326
MET A 329
VAL A 330
ASN A 334
 None
 1.31A 5b8iB-1z6rA:
0.0		 5b8iB-1z6rA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ab4 TRNA PSEUDOURIDINE
SYNTHASE B

(Thermotoga
maritima) 		PF01472
(PUA)
PF01509
(TruB_N)
PF16198
(TruB_C_2) 		4 LEU A 253
MET A 252
VAL A 234
ASN A 269
 None
 1.43A 5b8iB-2ab4A:
undetectable		 5b8iB-2ab4A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aq0 DNA REPAIR
ENDONUCLEASE XPF

(Homo sapiens) 		no annotation 4 LEU A  20
MET A  23
VAL A  26
ASN A  27
 None
 1.25A 5b8iB-2aq0A:
undetectable		 5b8iB-2aq0A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aq0 DNA REPAIR
ENDONUCLEASE XPF

(Homo sapiens) 		no annotation 4 LEU A  20
MET A  23
VAL A  26
ASN A  61
 None
 1.24A 5b8iB-2aq0A:
undetectable		 5b8iB-2aq0A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hc5 HYPOTHETICAL PROTEIN
YVYC

(Bacillus
subtilis) 		PF03646
(FlaG) 		4 LEU A  40
MET A  43
VAL A  44
ASN A  48
 None
 1.39A 5b8iB-2hc5A:
0.5		 5b8iB-2hc5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4s GENERAL SECRETION
PATHWAY PROTEIN C

(Vibrio cholerae) 		no annotation 4 LEU A 269
MET A 275
VAL A 274
ASN A 273
 None
 1.41A 5b8iB-2i4sA:
undetectable		 5b8iB-2i4sA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6v GENERAL SECRETION
PATHWAY PROTEIN C

(Vibrio cholerae) 		no annotation 4 LEU A 267
MET A 275
VAL A 274
ASN A 273
 None
 1.39A 5b8iB-2i6vA:
undetectable		 5b8iB-2i6vA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfw GLUTAMATE RACEMASE

(Enterococcus
faecium) 		PF01177
(Asp_Glu_race) 		4 LEU A 173
MET A 202
VAL A 201
ASN A 200
 None
 1.28A 5b8iB-2jfwA:
undetectable		 5b8iB-2jfwA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbe ATP-DEPENDENT RNA
HELICASE DBP5

(Saccharomyces
cerevisiae) 		PF00270
(DEAD) 		4 LEU A 153
MET A 152
VAL A 156
ASN A 157
 None
 1.27A 5b8iB-2kbeA:
0.0		 5b8iB-2kbeA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrj HBL B PROTEIN

(Bacillus cereus) 		PF05791
(Bacillus_HBL) 		4 LEU A  31
MET A 206
VAL A 205
ASN A 204
 None
 1.41A 5b8iB-2nrjA:
0.4		 5b8iB-2nrjA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogx MOLYBDENUM STORAGE
PROTEIN SUBUNIT
ALPHA

(Azotobacter
vinelandii) 		PF00696
(AA_kinase) 		4 LEU A  61
MET A  51
VAL A  50
ASN A 191
 None
None
None
ATP  A 281 (-2.8A)
 0.88A 5b8iB-2ogxA:
undetectable		 5b8iB-2ogxA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wau ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		4 LEU A2355
MET A2441
VAL A2356
ASN A2363
 None
 1.33A 5b8iB-2wauA:
undetectable		 5b8iB-2wauA:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ll8 CALCINEURIN SUBUNIT
B TYPE 1

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 LEU B 115
MET B 118
VAL B 119
ASN B 122
 None
 0.37A 5b8iB-3ll8B:
22.4		 5b8iB-3ll8B:
63.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcz O-METHYLTRANSFERASE

(Burkholderia
thailandensis) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 LEU A 302
MET A 305
VAL A 306
ASN A 121
 None
 1.21A 5b8iB-3mczA:
2.0		 5b8iB-3mczA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqm PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L

(Homo sapiens) 		PF00439
(Bromodomain) 		4 LEU A2488
MET A2510
VAL A2513
ASN A2516
 None
 1.50A 5b8iB-3mqmA:
undetectable		 5b8iB-3mqmA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mxu GLYCINE CLEAVAGE
SYSTEM H PROTEIN

(Bartonella
henselae) 		PF01597
(GCV_H) 		4 LEU A  47
MET A 100
VAL A  73
ASN A  43
 None
 1.15A 5b8iB-3mxuA:
undetectable		 5b8iB-3mxuA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3l CYTOCHROME P450

(Streptomyces
thioluteus) 		PF00067
(p450) 		4 LEU A  71
MET A  74
VAL A  75
ASN A 181
 None
 0.99A 5b8iB-3p3lA:
0.3		 5b8iB-3p3lA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0a NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		4 LEU B 516
MET B 540
VAL B 539
ASN B 568
 None
 1.37A 5b8iB-3v0aB:
0.2		 5b8iB-3v0aB:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avc LYSINE
ACETYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00027
(cNMP_binding)
PF13302
(Acetyltransf_3) 		4 LEU A 313
MET A 317
VAL A 318
ASN A 322
 None
 1.26A 5b8iB-4avcA:
undetectable		 5b8iB-4avcA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF00374
(NiFeSe_Hases) 		4 LEU A 291
MET A 287
VAL A 103
ASN A 104
 None
 1.27A 5b8iB-4ci0A:
0.2		 5b8iB-4ci0A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4duu PLASMINOGEN

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin) 		4 LEU A 649
MET A 788
VAL A 787
ASN A 790
 None
 1.43A 5b8iB-4duuA:
undetectable		 5b8iB-4duuA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1o HISTIDINE
DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 LEU A 362
MET A 120
VAL A 119
ASN A 118
 None
 1.30A 5b8iB-4e1oA:
undetectable		 5b8iB-4e1oA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6t MOLYBDENUM STORAGE
PROTEIN SUBUNIT
ALPHA

(Azotobacter
vinelandii) 		PF00696
(AA_kinase) 		4 LEU A  61
MET A  51
VAL A  50
ASN A 191
 None
None
None
ATP  A 301 (-2.8A)
 1.09A 5b8iB-4f6tA:
undetectable		 5b8iB-4f6tA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il1 CALMODULIN,
CALCINEURIN SUBUNIT
B TYPE 1,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Rattus
norvegicus) 		PF00149
(Metallophos)
PF13499
(EF-hand_7) 		4 LEU A 273
MET A 276
VAL A 277
ASN A 280
 None
 0.55A 5b8iB-4il1A:
18.5		 5b8iB-4il1A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k08 METHYL-ACCEPTING
CHEMOTAXIS SENSORY
TRANSDUCER

(Anaeromyxobacter
dehalogenans) 		PF17200
(sCache_2) 		4 LEU A  84
MET A 106
VAL A  97
ASN A  98
 None
 1.41A 5b8iB-4k08A:
undetectable		 5b8iB-4k08A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb6 ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-TRIPHOSPHATE
SYNTHASE SUBUNIT
PHNI

(Escherichia
coli) 		PF05861
(PhnI) 		4 LEU C  78
MET C  49
VAL C  48
ASN C  71
 None
 1.28A 5b8iB-4xb6C:
undetectable		 5b8iB-4xb6C:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxo GLYCOSYL HYDROLASE
FAMILY 26

(Bacteroides
ovatus) 		PF02156
(Glyco_hydro_26) 		4 LEU A 209
MET A 148
VAL A 147
ASN A 153
 None
 1.06A 5b8iB-4zxoA:
undetectable		 5b8iB-4zxoA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		4 LEU A 609
MET A 587
VAL A 586
ASN A 579
 None
 1.08A 5b8iB-5aeeA:
undetectable		 5b8iB-5aeeA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cw8 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR KSTR

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		4 LEU A  93
MET A  96
VAL A  97
ASN A 101
 None
 1.28A 5b8iB-5cw8A:
undetectable		 5b8iB-5cw8A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 LEU A 349
MET A 352
VAL A 354
ASN A 355
 None
 1.24A 5b8iB-5dmyA:
undetectable		 5b8iB-5dmyA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5duy GALNAC/GAL-SPECIFIC
LECTIN

(Crenomytilus
grayanus) 		no annotation 4 LEU A  30
MET A  78
VAL A  79
ASN A  27
 None
None
None
GOL  A 202 (-3.5A)
 1.48A 5b8iB-5duyA:
undetectable		 5b8iB-5duyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8y GALNAC/GAL-SPECIFIC
LECTIN

(Crenomytilus
grayanus) 		no annotation 4 LEU A  30
MET A  78
VAL A  79
ASN A  27
 None
None
None
X6X  A 201 ( 3.5A)
 1.48A 5b8iB-5f8yA:
undetectable		 5b8iB-5f8yA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thm ESTERASE-6

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 LEU A 132
MET A 125
VAL A 124
ASN A 123
 None
MLY  A  91 ( 3.9A)
None
None
 1.15A 5b8iB-5thmA:
undetectable		 5b8iB-5thmA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uao TRYPTOPHANE-5-HALOGE
NASE

(Microbispora
sp. ATCC
PTA-5024) 		PF04820
(Trp_halogenase) 		4 LEU A 239
MET A 342
VAL A 341
ASN A 340
 None
 1.46A 5b8iB-5uaoA:
undetectable		 5b8iB-5uaoA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue8 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF00130
(C1_1)
PF00168
(C2)
PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		4 LEU A1336
MET A1332
VAL A1360
ASN A1359
 None
 1.47A 5b8iB-5ue8A:
undetectable		 5b8iB-5ue8A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ul4 OXSB PROTEIN

(Bacillus
megaterium) 		PF02310
(B12-binding) 		4 LEU A 644
MET A 690
VAL A 689
ASN A 688
 None
 1.39A 5b8iB-5ul4A:
1.1		 5b8iB-5ul4A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi UNCHARACTERIZED
PROTEIN

(Trichomonas
vaginalis) 		PF03297
(Ribosomal_S25) 		4 LEU Z  67
MET Z  34
VAL Z  38
ASN Z  41
 None
 1.36A 5b8iB-5xyiZ:
undetectable		 5b8iB-5xyiZ:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a91 -

(-) 		no annotation 4 LEU A 736
MET A 645
VAL A 644
ASN A 643
 None
 1.01A 5b8iB-6a91A:
1.5		 5b8iB-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B

(Homo sapiens) 		no annotation 4 LEU A 561
MET A 534
VAL A 533
ASN A 532
 None
 1.27A 5b8iB-6ek6A:
undetectable		 5b8iB-6ek6A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhe POLYGALACTURONASE

(Pectobacterium
carotovorum) 		PF00295
(Glyco_hydro_28) 		5 ASP A 224
VAL A 267
ILE A 242
ILE A 204
PHE A 247
 None
 1.16A 5b8iC-1bheA:
undetectable		 5b8iC-1bheA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		6 PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
 None
 1.14A 5b8iC-1fd9A:
15.7		 5b8iC-1fd9A:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		8 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
 None
 0.62A 5b8iC-1fd9A:
15.7		 5b8iC-1fd9A:
26.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fkk FK506 BINDING
PROTEIN

(Bos taurus) 		PF00254
(FKBP_C) 		10 TYR A  26
ASP A  37
ARG A  42
PHE A  46
VAL A  55
ILE A  56
TRP A  59
TYR A  82
ILE A  91
PHE A  99
 None
 0.67A 5b8iC-1fkkA:
19.8		 5b8iC-1fkkA:
41.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foh PHENOL HYDROXYLASE

(Cutaneotrichosporon
cutaneum) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		5 ARG A  44
VAL A  13
ILE A  12
LEU A 125
ILE A 128
 FAD  A 801 (-3.2A)
FAD  A 801 (-4.8A)
None
None
None
 1.18A 5b8iC-1fohA:
undetectable		 5b8iC-1fohA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gm6 SALIVARY LIPOCALIN

(Sus scrofa) 		PF00061
(Lipocalin) 		5 TYR A  87
PHE A  71
VAL A  64
LEU A  27
ILE A  35
 None
 1.05A 5b8iC-1gm6A:
undetectable		 5b8iC-1gm6A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Escherichia
coli) 		PF03740
(PdxJ) 		5 ASP A  26
ARG A  56
ILE A  42
PHE A  32
ILE A  33
 None
 1.22A 5b8iC-1ixpA:
undetectable		 5b8iC-1ixpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		6 PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 1.02A 5b8iC-1jvwA:
14.8		 5b8iC-1jvwA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		8 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.65A 5b8iC-1jvwA:
14.8		 5b8iC-1jvwA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		8 TYR A  92
ASP A 103
ARG A 108
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
 None
 0.81A 5b8iC-1jvwA:
14.8		 5b8iC-1jvwA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		6 PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
PHE A 130
 None
 0.89A 5b8iC-1kt1A:
15.1		 5b8iC-1kt1A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		6 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
 None
 1.14A 5b8iC-1kt1A:
15.1		 5b8iC-1kt1A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		6 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
PHE A 130
 None
 0.75A 5b8iC-1kt1A:
15.1		 5b8iC-1kt1A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 ASP A 101
ARG A   8
PHE A 106
VAL A 188
ILE A 140
 None
 1.15A 5b8iC-1lnlA:
undetectable		 5b8iC-1lnlA:
18.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n1a FKBP52

(Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
 0.63A 5b8iC-1n1aA:
17.5		 5b8iC-1n1aA:
37.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pbk FKBP25

(Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A 135
ASP A 146
VAL A 171
ILE A 172
TRP A 175
TYR A 198
ILE A 208
PHE A 216
 RAP  A 225 (-3.9A)
RAP  A 225 (-3.0A)
RAP  A 225 (-3.5A)
RAP  A 225 (-3.9A)
RAP  A 225 (-3.4A)
RAP  A 225 (-4.6A)
RAP  A 225 ( 4.9A)
None
 0.34A 5b8iC-1pbkA:
18.9		 5b8iC-1pbkA:
41.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6h FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA

(Escherichia
coli) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		6 PHE A 168
ILE A 174
TRP A 177
TYR A 200
ILE A 208
PHE A 216
 None
 1.32A 5b8iC-1q6hA:
15.3		 5b8iC-1q6hA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6h FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA

(Escherichia
coli) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		9 TYR A 146
ASP A 157
ARG A 162
VAL A 173
ILE A 174
TRP A 177
TYR A 200
ILE A 208
PHE A 216
 None
 0.56A 5b8iC-1q6hA:
15.3		 5b8iC-1q6hA:
24.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r9h FK506 BINDING
PROTEIN FAMILY

(Caenorhabditis
elegans) 		PF00254
(FKBP_C) 		10 TYR A  40
ASP A  51
ARG A  56
PHE A  60
VAL A  69
ILE A  70
TRP A  73
TYR A  96
ILE A 105
PHE A 113
 None
 0.72A 5b8iC-1r9hA:
18.6		 5b8iC-1r9hA:
41.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1

(Saccharomyces
cerevisiae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.19A 5b8iC-1ry2A:
undetectable		 5b8iC-1ry2A:
11.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u79 FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
3

(Arabidopsis
thaliana) 		PF00254
(FKBP_C) 		9 TYR A  37
ASP A  48
VAL A  66
ILE A  67
TRP A  70
TYR A  99
LEU A 112
ILE A 113
PHE A 121
 None
 0.75A 5b8iC-1u79A:
16.9		 5b8iC-1u79A:
34.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 OUTER CAPSID PROTEIN
P8

(Rice dwarf
virus) 		no annotation 5 PHE P 414
ILE P 100
TYR P  80
LEU P  82
PHE P  71
 None
 1.18A 5b8iC-1uf2P:
undetectable		 5b8iC-1uf2P:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwv 23S RRNA
(URACIL-5-)-METHYLTR
ANSFERASE RUMA

(Escherichia
coli) 		PF01938
(TRAM)
PF05958
(tRNA_U5-meth_tr) 		5 ASP A 292
PHE A 294
VAL A 372
ILE A 376
PHE A 357
 None
 1.07A 5b8iC-1uwvA:
undetectable		 5b8iC-1uwvA:
13.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yat FK506 BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		12 TYR A  26
ASP A  37
ARG A  42
PHE A  46
VAL A  55
ILE A  56
TRP A  59
TYR A  82
PHE A  87
LEU A  90
ILE A  91
PHE A  99
 FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.3A)
FK5  A 108 (-3.7A)
FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.4A)
FK5  A 108 ( 3.7A)
FK5  A 108 ( 3.6A)
FK5  A 108 ( 4.7A)
FK5  A 108 (-4.0A)
FK5  A 108 ( 4.6A)
None
None
 0.51A 5b8iC-1yatA:
19.7		 5b8iC-1yatA:
45.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR

(Saccharomyces
cerevisiae) 		PF00515
(TPR_1)
PF13181
(TPR_8)
PF13432
(TPR_16) 		5 ILE A 367
PHE A 341
LEU A 342
ILE A 338
PHE A 264
 None
 1.06A 5b8iC-2gw1A:
undetectable		 5b8iC-2gw1A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iue INTEGRIN BETA-2-LIKE
PROTEIN

(Mus musculus) 		PF00362
(Integrin_beta) 		5 TYR A 179
PHE A 116
VAL A 153
ILE A 186
LEU A 108
 None
 1.15A 5b8iC-2iueA:
undetectable		 5b8iC-2iueA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l89 PWWP
DOMAIN-CONTAINING
PROTEIN 1

(Schizosaccharomyces
pombe) 		PF00855
(PWWP) 		5 PHE A  94
VAL A  58
PHE A 119
LEU A 120
ILE A 116
 None
 1.16A 5b8iC-2l89A:
undetectable		 5b8iC-2l89A:
20.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lpv FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Aedes aegypti) 		PF00254
(FKBP_C) 		5 TYR A  27
PHE A  47
ILE A  57
TRP A  60
ILE A  92
 None
 1.11A 5b8iC-2lpvA:
16.3		 5b8iC-2lpvA:
41.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lpv FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Aedes aegypti) 		PF00254
(FKBP_C) 		5 TYR A  27
VAL A  56
ILE A  57
TRP A  60
ILE A  92
 None
 1.10A 5b8iC-2lpvA:
16.3		 5b8iC-2lpvA:
41.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pbc FK506-BINDING
PROTEIN 2

(Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  56
ASP A  67
PHE A  76
VAL A  85
ILE A  86
TRP A  89
TYR A 112
ILE A 121
PHE A 129
 PEG  A 201 (-4.4A)
None
PEG  A 201 ( 3.9A)
PEG  A 201 (-3.6A)
PEG  A 201 (-3.8A)
PEG  A 201 (-3.7A)
None
None
None
 0.85A 5b8iC-2pbcA:
15.5		 5b8iC-2pbcA:
39.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qrx GM27569P

(Drosophila
melanogaster) 		PF01997
(Translin) 		5 ASP A 140
VAL A  31
ILE A  34
TYR A  73
LEU A 136
 None
 1.17A 5b8iC-2qrxA:
undetectable		 5b8iC-2qrxA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qul D-TAGATOSE
3-EPIMERASE

(Pseudomonas
cichorii) 		PF01261
(AP_endonuc_2) 		5 ARG A 217
VAL A 244
ILE A 243
LEU A 225
ILE A 230
 MN  A 291 ( 4.8A)
None
None
None
None
 1.09A 5b8iC-2qulA:
undetectable		 5b8iC-2qulA:
21.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vcd OUTER MEMBRANE
PROTEIN MIP

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 ASP A  66
VAL A  82
ILE A  83
TRP A  86
PHE A 126
 RAP  A 138 (-2.7A)
RAP  A 138 (-3.2A)
RAP  A 138 (-3.6A)
RAP  A 138 (-2.3A)
RAP  A 138 ( 4.7A)
 0.82A 5b8iC-2vcdA:
12.8		 5b8iC-2vcdA:
30.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vcd OUTER MEMBRANE
PROTEIN MIP

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 TYR A  55
ASP A  66
VAL A  82
ILE A  83
TRP A  86
 RAP  A 138 (-2.6A)
RAP  A 138 (-2.7A)
RAP  A 138 (-3.2A)
RAP  A 138 (-3.6A)
RAP  A 138 (-2.3A)
 0.86A 5b8iC-2vcdA:
12.8		 5b8iC-2vcdA:
30.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vcd OUTER MEMBRANE
PROTEIN MIP

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 TYR A  55
VAL A  82
ILE A  83
TRP A  86
TYR A 109
 RAP  A 138 (-2.6A)
RAP  A 138 (-3.2A)
RAP  A 138 (-3.6A)
RAP  A 138 (-2.3A)
RAP  A 138 (-3.8A)
 0.68A 5b8iC-2vcdA:
12.8		 5b8iC-2vcdA:
30.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vn1 70 KDA
PEPTIDYLPROLYL
ISOMERASE

(Plasmodium
falciparum) 		PF00254
(FKBP_C) 		10 TYR A  44
ASP A  56
ARG A  61
PHE A  65
VAL A  74
ILE A  75
TRP A  78
TYR A 101
ILE A 110
PHE A 118
 FK5  A 501 (-4.1A)
FK5  A 501 (-3.4A)
FK5  A 501 (-3.9A)
FK5  A 501 (-4.1A)
FK5  A 501 (-3.5A)
FK5  A 501 (-4.3A)
FK5  A 501 (-3.3A)
FK5  A 501 (-4.7A)
None
FK5  A 501 (-4.8A)
 0.48A 5b8iC-2vn1A:
18.4		 5b8iC-2vn1A:
36.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y78 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		9 TYR A  33
ARG A  49
PHE A  53
VAL A  62
ILE A  63
TRP A  66
TYR A  89
ILE A  98
PHE A 106
 None
 0.55A 5b8iC-2y78A:
17.1		 5b8iC-2y78A:
39.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y78 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		9 TYR A  33
ASP A  44
ARG A  49
PHE A  53
ILE A  63
TRP A  66
TYR A  89
ILE A  98
PHE A 106
 None
 0.71A 5b8iC-2y78A:
17.1		 5b8iC-2y78A:
39.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aih PROTEIN OS-9

(Homo sapiens) 		PF07915
(PRKCSH) 		5 ASP A 205
ARG A 226
PHE A 122
LEU A 111
ILE A 207
 None
 1.25A 5b8iC-3aihA:
undetectable		 5b8iC-3aihA:
23.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b7x FK506-BINDING
PROTEIN 6

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  61
ASP A  73
TYR A 118
ILE A 127
PHE A 135
 None
 0.89A 5b8iC-3b7xA:
14.4		 5b8iC-3b7xA:
33.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00579
(tRNA-synt_1b) 		5 ASP A 208
ARG A 214
PHE A 212
VAL A 106
TYR A 155
 None
 1.24A 5b8iC-3focA:
undetectable		 5b8iC-3focA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gi8 UNCHARACTERIZED
PROTEIN MJ0609

(Methanocaldococcus
jannaschii) 		PF13520
(AA_permease_2) 		5 PHE C 198
VAL C  55
ILE C 359
PHE C 378
ILE C 381
 None
 1.14A 5b8iC-3gi8C:
undetectable		 5b8iC-3gi8C:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2t BASEPLATE STRUCTURAL
PROTEIN GP6

(Escherichia
virus T4) 		no annotation 5 VAL A 541
ILE A 540
LEU A 611
ILE A 606
PHE A 515
 None
 1.05A 5b8iC-3h2tA:
undetectable		 5b8iC-3h2tA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb4 VP1
VP3

(Parechovirus B) 		PF00073
(Rhv)
no annotation 		5 PHE A 123
VAL A  84
ILE A  87
TYR C 122
PHE C 233
 None
 1.19A 5b8iC-3jb4A:
undetectable		 5b8iC-3jb4A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbh MYOSIN 2 ESSENTIAL
LIGHT CHAIN STRIATED
MUSCLE
MYOSIN 2 HEAVY CHAIN
STRIATED MUSCLE

(Aphonopelma) 		PF00063
(Myosin_head)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N)
no annotation 		5 ASP C  31
ARG C  57
ILE C  18
PHE C  16
PHE A 802
 None
 1.20A 5b8iC-3jbhC:
undetectable		 5b8iC-3jbhC:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2o F-BOX ONLY PROTEIN 4

(Homo sapiens) 		PF00646
(F-box) 		5 PHE B 318
VAL B 275
ILE B 276
LEU B 234
ILE B 217
 None
 1.25A 5b8iC-3l2oB:
undetectable		 5b8iC-3l2oB:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lca PROTEIN TOM71

(Saccharomyces
cerevisiae) 		PF00515
(TPR_1)
PF13181
(TPR_8)
PF14559
(TPR_19) 		5 ILE A 382
PHE A 356
LEU A 357
ILE A 353
PHE A 276
 None
 0.89A 5b8iC-3lcaA:
undetectable		 5b8iC-3lcaA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(marine
actinobacterium
PHSC20C1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASP A 195
VAL A 183
ILE A 212
LEU A 228
ILE A 232
 None
 1.11A 5b8iC-3msyA:
undetectable		 5b8iC-3msyA:
16.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
 0.84A 5b8iC-3o5dA:
17.9		 5b8iC-3o5dA:
32.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TYR A 113
ILE A 122
PHE A 130
 None
 0.89A 5b8iC-3o5eA:
18.0		 5b8iC-3o5eA:
33.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
 0.91A 5b8iC-3o5eA:
18.0		 5b8iC-3o5eA:
33.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pa7 70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE

(Plasmodium
vivax) 		PF00254
(FKBP_C) 		10 TYR A  43
ASP A  55
ARG A  60
PHE A  64
VAL A  73
ILE A  74
TRP A  77
TYR A 100
ILE A 109
PHE A 117
 None
 0.78A 5b8iC-3pa7A:
18.0		 5b8iC-3pa7A:
38.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00619
(CARD)
PF00653
(BIR)
PF13920
(zf-C3HC4_3) 		5 ASP A 511
ARG A 569
VAL A 475
ILE A 478
ILE A 461
 None
 1.18A 5b8iC-3t6pA:
undetectable		 5b8iC-3t6pA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 TYR A 569
VAL A 210
ILE A 224
TYR A 226
ILE A 200
 None
 1.25A 5b8iC-3um6A:
undetectable		 5b8iC-3um6A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		5 PHE A1209
ILE A1181
PHE A1137
LEU A1138
PHE A1153
 None
 1.13A 5b8iC-4a4zA:
undetectable		 5b8iC-4a4zA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N) 		5 PHE A 258
VAL A 290
ILE A 291
LEU A 352
ILE A 349
 None
 1.09A 5b8iC-4b8bA:
undetectable		 5b8iC-4b8bA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N) 		5 PHE A 258
VAL A 290
LEU A 352
ILE A 349
PHE A 282
 None
 1.15A 5b8iC-4b8bA:
undetectable		 5b8iC-4b8bA:
11.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		7 ASP A 324
VAL A 341
ILE A 342
TRP A 345
TYR A 368
ILE A 376
PHE A 384
 None
 0.78A 5b8iC-4bf8A:
15.3		 5b8iC-4bf8A:
30.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		5 TYR A 313
ASP A 324
PHE A 332
TRP A 345
PHE A 384
 None
 1.01A 5b8iC-4bf8A:
15.3		 5b8iC-4bf8A:
30.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		6 TYR A 313
ASP A 324
VAL A 341
ILE A 342
TRP A 345
PHE A 384
 None
 0.71A 5b8iC-4bf8A:
15.3		 5b8iC-4bf8A:
30.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buj ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT) 		5 PHE A1209
ILE A1181
PHE A1137
LEU A1138
PHE A1153
 None
 1.25A 5b8iC-4bujA:
undetectable		 5b8iC-4bujA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0e NOT1

(Chaetomium
thermophilum) 		PF04054
(Not1) 		5 TYR A2111
ASP A2075
ARG A2059
PHE A2069
ILE A2119
 None
 1.21A 5b8iC-4c0eA:
undetectable		 5b8iC-4c0eA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dip PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP14

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  52
TRP A  88
TYR A 111
ILE A 119
PHE A 127
 None
 0.55A 5b8iC-4dipA:
16.7		 5b8iC-4dipA:
29.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dz3 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		10 TYR A  33
ASP A  44
ARG A  49
PHE A  53
VAL A  62
ILE A  63
TRP A  66
TYR A  89
ILE A  98
PHE A 106
 FK5  A 201 ( 3.9A)
FK5  A 201 (-3.5A)
FK5  A 201 ( 3.7A)
FK5  A 201 (-4.1A)
FK5  A 201 ( 3.6A)
FK5  A 201 (-3.8A)
FK5  A 201 (-3.4A)
FK5  A 201 (-4.7A)
None
FK5  A 201 (-4.8A)
 0.52A 5b8iC-4dz3A:
18.0		 5b8iC-4dz3A:
41.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola) 		PF13354
(Beta-lactamase2) 		5 PHE A 195
VAL A 249
ILE A 250
PHE A 290
ILE A 292
 None
None
None
EDO  A 402 ( 3.7A)
None
 1.21A 5b8iC-4ev4A:
undetectable		 5b8iC-4ev4A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus) 		PF01636
(APH) 		5 TYR A 260
ASP A 212
PHE A 259
VAL A 135
LEU A 178
 None
 1.24A 5b8iC-4h05A:
undetectable		 5b8iC-4h05A:
18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B

(Homo sapiens) 		PF00254
(FKBP_C) 		7 ARG A  42
PHE A  46
VAL A  55
ILE A  56
TYR A  82
ILE A  91
PHE A  99
 None
 0.88A 5b8iC-4iqcA:
19.7		 5b8iC-4iqcA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B

(Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A  26
ASP A  37
ARG A  42
PHE A  46
ILE A  56
TYR A  82
ILE A  91
PHE A  99
 None
 0.88A 5b8iC-4iqcA:
19.7		 5b8iC-4iqcA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4

(Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  57
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.79A 5b8iC-4lawA:
18.3		 5b8iC-4lawA:
30.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4

(Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  57
ASP A  68
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.90A 5b8iC-4lawA:
18.3		 5b8iC-4lawA:
30.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmw GLUTATHIONE
TRANSFERASE

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		5 ARG A 104
PHE A 106
ILE A  91
LEU A  37
ILE A   6
 None
None
None
FMT  A 308 ( 4.4A)
FMT  A 308 ( 4.7A)
 1.12A 5b8iC-4lmwA:
undetectable		 5b8iC-4lmwA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4msp PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP14

(Homo sapiens) 		PF00254
(FKBP_C)
PF13499
(EF-hand_7) 		5 TYR A  33
TRP A  69
TYR A  92
ILE A 100
PHE A 108
 None
 0.37A 5b8iC-4mspA:
17.1		 5b8iC-4mspA:
22.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nnr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2

(Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  56
ASP A  67
PHE A  76
VAL A  85
ILE A  86
TRP A  89
TYR A 112
ILE A 121
PHE A 129
 FK5  A 201 (-4.1A)
FK5  A 201 (-3.4A)
FK5  A 201 (-4.0A)
FK5  A 201 (-3.4A)
FK5  A 201 (-3.8A)
FK5  A 201 (-3.5A)
FK5  A 201 (-4.5A)
None
FK5  A 201 (-4.9A)
 0.34A 5b8iC-4nnrA:
15.6		 5b8iC-4nnrA:
36.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odm PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD

(Thermus
thermophilus) 		PF00254
(FKBP_C) 		5 TYR A  13
ASP A  23
ILE A  37
TYR A  63
PHE A 128
 None
 0.49A 5b8iC-4odmA:
11.4		 5b8iC-4odmA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA

(Homo sapiens;
Thermus
thermophilus) 		PF00254
(FKBP_C) 		6 TYR A  13
ASP A  23
ILE A  37
TYR A  63
ILE A  72
PHE A  80
 FK5  A 201 ( 3.6A)
FK5  A 201 (-3.6A)
FK5  A 201 (-3.9A)
FK5  A 201 (-4.4A)
None
FK5  A 201 ( 4.8A)
 0.38A 5b8iC-4odrA:
13.1		 5b8iC-4odrA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opw UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF10988
(DUF2807) 		5 ASP A  68
VAL A  49
ILE A  50
ILE A  65
PHE A  88
 None
None
None
None
EDO  A 301 (-4.3A)
 1.11A 5b8iC-4opwA:
undetectable		 5b8iC-4opwA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pb6 VP1

(Feline
calicivirus) 		PF00915
(Calici_coat) 		5 ASP A 241
VAL A 235
ILE A 234
LEU A 652
ILE A 187
 None
 1.12A 5b8iC-4pb6A:
undetectable		 5b8iC-4pb6A:
15.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  57
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
 0.85A 5b8iC-4r0xA:
18.4		 5b8iC-4r0xA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A  57
ASP A  68
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TYR A 113
PHE A 130
 None
 0.88A 5b8iC-4r0xA:
18.4		 5b8iC-4r0xA:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq1 GLUCOSE-6-PHOSPHATE
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		5 VAL A 305
ILE A 306
TYR A 506
LEU A 338
ILE A 505
 None
 1.25A 5b8iC-5aq1A:
undetectable		 5b8iC-5aq1A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 NEQ263
V-TYPE ATP SYNTHASE
ALPHA CHAIN

(Nanoarchaeum
equitans) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		5 ARG A 335
VAL B  31
ILE B  30
LEU B 235
ILE B 200
 None
 0.94A 5b8iC-5bn4A:
undetectable		 5b8iC-5bn4A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5css TRIOSEPHOSPHATE
ISOMERASE

(Thermoplasma
acidophilum) 		PF00121
(TIM) 		5 ARG A  96
ILE A 162
TYR A 163
LEU A 115
ILE A 134
 None
 1.17A 5b8iC-5cssA:
undetectable		 5b8iC-5cssA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  26
ASP A  37
ARG A  42
PHE A  46
VAL A  55
ILE A  56
TRP A  59
TYR A  82
PHE A 146
 None
 0.74A 5b8iC-5i7pA:
18.1		 5b8iC-5i7pA:
28.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7q PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE 16
KDA PEPTIDYL-PROLYL
CIS-TRANS
ISOMERASE,PEPTIDYL-P
ROLYL CIS-TRANS
ISOMERASE FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  26
ASP A  37
ARG A  42
PHE A  46
VAL A  55
ILE A  56
TRP A  59
TYR A  82
PHE A 147
 None
 0.65A 5b8iC-5i7qA:
18.3		 5b8iC-5i7qA:
30.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1

(Candida
albicans) 		PF00254
(FKBP_C) 		9 TYR A  30
ASP A  41
ARG A  46
PHE A  50
VAL A  59
ILE A  60
TRP A  63
TYR A  97
ILE A 102
 None
 1.33A 5b8iC-5i98A:
19.0		 5b8iC-5i98A:
38.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1

(Candida
albicans) 		PF00254
(FKBP_C) 		10 TYR A  30
ASP A  41
ARG A  46
PHE A  50
VAL A  59
ILE A  60
TRP A  63
TYR A  97
ILE A 106
PHE A 114
 None
 0.64A 5b8iC-5i98A:
19.0		 5b8iC-5i98A:
38.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j6e FK506-BINDING
PROTEIN 1A

(Aspergillus
fumigatus) 		PF00254
(FKBP_C) 		11 TYR A  27
ASP A  38
ARG A  43
PHE A  47
VAL A  56
ILE A  57
TRP A  60
TYR A  83
PHE A  88
ILE A  92
PHE A 100
 None
 0.80A 5b8iC-5j6eA:
20.9		 5b8iC-5j6eA:
54.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcv LMO2181 PROTEIN

(Listeria
monocytogenes) 		PF04203
(Sortase) 		5 ASP A 125
VAL A  75
ILE A  89
TYR A 161
ILE A 221
 None
 1.07A 5b8iC-5jcvA:
undetectable		 5b8iC-5jcvA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msz THERMOBIA DOMESTICA
DOMESTICA AA15

(Thermobia
domestica) 		no annotation 5 ASP A  84
VAL A  72
ILE A 190
TYR A  75
ILE A  81
 None
 1.18A 5b8iC-5mszA:
undetectable		 5b8iC-5mszA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8t UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei;
Saccharomyces
cerevisiae) 		no annotation 10 TYR A  33
ASP A  44
ARG A  49
PHE A  53
VAL A  62
ILE A  63
TRP A  66
TYR A  89
ILE A  98
PHE A 106
 8ZV  A 201 (-3.8A)
8ZV  A 201 (-3.9A)
8ZV  A 201 (-3.6A)
8ZV  A 201 (-3.9A)
8ZV  A 201 (-3.6A)
8ZV  A 201 (-4.0A)
8ZV  A 201 (-3.3A)
8ZV  A 201 (-4.6A)
8ZV  A 201 ( 4.8A)
8ZV  A 201 (-4.6A)
 0.61A 5b8iC-5v8tA:
17.9		 5b8iC-5v8tA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkq NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L

(Drosophila
melanogaster) 		PF00023
(Ank)
PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4) 		5 PHE A1234
VAL A1246
ILE A1247
LEU A1259
ILE A1580
 None
 1.23A 5b8iC-5vkqA:
undetectable		 5b8iC-5vkqA:
5.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00254
(FKBP_C) 		8 TYR A 147
ASP A 158
VAL A 171
ILE A 172
TRP A 175
TYR A 198
ILE A 207
PHE A 215
 TLA  A 301 ( 4.4A)
TLA  A 301 (-3.7A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
None
None
None
 0.68A 5b8iC-5xb0A:
15.2		 5b8iC-5xb0A:
31.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00254
(FKBP_C) 		7 TYR A 147
PHE A 166
ILE A 172
TRP A 175
TYR A 198
ILE A 207
PHE A 215
 TLA  A 301 ( 4.4A)
TLA  A 301 ( 4.6A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
None
None
None
 1.07A 5b8iC-5xb0A:
15.2		 5b8iC-5xb0A:
31.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 9 TYR A  38
ASP A  49
ARG A  54
PHE A  58
VAL A  67
ILE A  68
TRP A  71
TYR A  94
PHE A 111
 None
 0.78A 5b8iC-6b4pA:
18.1		 5b8iC-6b4pA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 9 TYR A  38
ASP A  49
ARG A  54
PHE A  58
VAL A  67
ILE A  68
TYR A  94
ILE A 103
PHE A 111
 None
 0.70A 5b8iC-6b4pA:
18.1		 5b8iC-6b4pA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 9 TYR A  38
ASP A  49
ARG A  54
VAL A  67
ILE A  68
TYR A  94
LEU A 102
ILE A 103
PHE A 111
 None
 0.73A 5b8iC-6b4pA:
18.1		 5b8iC-6b4pA:
38.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzc GLUCOSE-6-PHOSPHATE
ISOMERASE

(Elizabethkingia
anophelis) 		no annotation 5 VAL A 150
ILE A 204
PHE A 239
ILE A 254
PHE A 130
 None
None
None
None
EDO  A 604 (-4.6A)
 1.21A 5b8iC-6bzcA:
undetectable		 5b8iC-6bzcA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d12 LA-RELATED PROTEIN 7

(Homo sapiens) 		no annotation 5 ARG A 472
VAL A 457
ILE A 456
TYR A 532
ILE A 536
 G  C 333 ( 3.7A)
None
None
G  C 331 ( 4.7A)
G  C 331 ( 4.0A)
 1.08A 5b8iC-6d12A:
undetectable		 5b8iC-6d12A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE SUBUNIT
BETA

(Trypanosoma
brucei) 		no annotation 5 VAL D 145
ILE D 146
TYR D 152
LEU D 334
ILE D 158
 None
 1.23A 5b8iC-6f5dD:
undetectable		 5b8iC-6f5dD:
19.23