SIMILAR PATTERNS OF AMINO ACIDS FOR 5B6I_B_ADNB302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bow MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR BMRR

(Bacillus
subtilis) 		PF06445
(GyrI-like) 		4 ASP A 131
THR A  54
TYR A  68
THR A  67
 None
 1.25A 5b6iB-1bowA:
undetectable		 5b6iB-1bowA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		4 ASP A 738
TRP A 736
THR A 404
SER A 457
 None
 1.36A 5b6iB-1d0nA:
0.0		 5b6iB-1d0nA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6v CHIMERIC GERMLINE
PRECURSOR OF
OXY-COPE CATALYTIC
ANTIBODY AZ-28
(LIGHT CHAIN)

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP L 170
THR L 172
TYR L 140
THR L 109
 CD  L 502 ( 4.8A)
None
None
None
 1.28A 5b6iB-1d6vL:
0.8		 5b6iB-1d6vL:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji6 PESTICIDIAL CRYSTAL
PROTEIN CRY3BB

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 ASP A 425
THR A 440
TYR A 441
THR A 422
 None
 1.27A 5b6iB-1ji6A:
0.0		 5b6iB-1ji6A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		4 ASP A 275
THR A 270
THR A 206
SER A 284
 None
 1.48A 5b6iB-1lnsA:
1.6		 5b6iB-1lnsA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL

(Homo sapiens) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 ASP A  73
TRP A  46
THR A  76
THR A  41
 None
 0.91A 5b6iB-1qk1A:
undetectable		 5b6iB-1qk1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmo MANNOSE BINDING
LECTIN, FRIL

(Lablab
purpureus) 		PF00139
(Lectin_legB) 		4 ASP E 230
TYR A  80
THR A  78
SER A  82
 None
 1.49A 5b6iB-1qmoE:
undetectable		 5b6iB-1qmoE:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rmg RHAMNOGALACTURONASE
A

(Aspergillus
aculeatus) 		PF00295
(Glyco_hydro_28) 		4 THR A 367
TYR A 369
THR A 370
SER A 352
 MAN  A 447 (-2.4A)
None
BMA  A 427 (-2.2A)
BMA  A 427 ( 4.3A)
 1.15A 5b6iB-1rmgA:
0.0		 5b6iB-1rmgA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfj 3-DEHYDROQUINATE
DEHYDRATASE

(Staphylococcus
aureus) 		PF01487
(DHquinase_I) 		4 ASP A 102
THR A  68
TYR A  69
THR A  71
 None
DHK  A 239 ( 3.8A)
None
None
 0.99A 5b6iB-1sfjA:
undetectable		 5b6iB-1sfjA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2y DNA/RNA-BINDING
PROTEIN ALBA 2

(Sulfolobus
solfataricus) 		PF01918
(Alba) 		4 THR A  39
TYR A  80
THR A  68
SER A  79
 None
 1.38A 5b6iB-2a2yA:
undetectable		 5b6iB-2a2yA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aml SIS DOMAIN PROTEIN

(Listeria
monocytogenes) 		PF01380
(SIS) 		4 ASP A 301
THR A 304
TYR A 292
THR A 291
 None
 1.36A 5b6iB-2amlA:
2.1		 5b6iB-2amlA:
21.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE

(Streptomyces
cattleya) 		PF01887
(SAM_adeno_trans) 		6 ASP A  16
TRP A  50
THR A  76
TYR A  77
THR A  80
SER A 158
 SA8  A1299 (-2.9A)
SA8  A1299 (-4.2A)
SA8  A1299 ( 4.7A)
None
SA8  A1299 (-4.0A)
SA8  A1299 (-2.6A)
 0.15A 5b6iB-2c4tA:
43.3		 5b6iB-2c4tA:
82.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cf5 CINNAMYL ALCOHOL
DEHYDROGENASE

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASP A 356
TRP A  13
THR A  11
TYR A  25
 None
 1.23A 5b6iB-2cf5A:
undetectable		 5b6iB-2cf5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5a PROTEIN (ANTIBODY
2F5 (LIGHT CHAIN))

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP L 170
THR L 172
TYR L 140
THR L 109
 None
 1.27A 5b6iB-2f5aL:
undetectable		 5b6iB-2f5aL:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE

(Aedes aegypti) 		PF00266
(Aminotran_5) 		4 ASP A 180
TRP A 105
THR A 151
SER A 184
 LLP  A 206 ( 2.9A)
LLP  A 206 ( 3.5A)
LLP  A 206 ( 4.6A)
None
 1.12A 5b6iB-2hufA:
undetectable		 5b6iB-2hufA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww2 ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		4 ASP A  79
THR A  78
TYR A  77
THR A  38
 None
None
MPD  A 759 (-3.9A)
None
 1.43A 5b6iB-2ww2A:
undetectable		 5b6iB-2ww2A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtj FAB FROM A HUMAN
MONOCLONAL ANTIBODY,
1D05

(Homo sapiens) 		PF07654
(C1-set) 		4 ASP C 169
THR C 171
TYR C 139
THR C 108
 None
 1.41A 5b6iB-2xtjC:
undetectable		 5b6iB-2xtjC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwu IMPORTIN13

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1) 		4 TRP B 364
THR B 430
TYR B 365
THR B 366
 None
 1.39A 5b6iB-2xwuB:
undetectable		 5b6iB-2xwuB:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brz TODX

(Pseudomonas
putida) 		PF03349
(Toluene_X) 		4 ASP A   5
TRP A 304
TYR A 303
SER A 280
 None
 1.44A 5b6iB-3brzA:
undetectable		 5b6iB-3brzA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2

(Burkholderia
pseudomallei) 		PF00464
(SHMT) 		4 ASP A 292
THR A 289
TYR A 290
THR A 373
 None
None
GOL  A 425 (-4.4A)
None
 1.39A 5b6iB-3ecdA:
undetectable		 5b6iB-3ecdA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egf EPIDERMAL GROWTH
FACTOR

(Mus musculus) 		PF00008
(EGF) 		4 ASP A  40
THR A  30
TYR A  29
SER A  28
 None
 1.28A 5b6iB-3egfA:
undetectable		 5b6iB-3egfA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgq HDA1 COMPLEX SUBUNIT
3

(Saccharomyces
cerevisiae) 		PF11496
(HDA2-3) 		4 ASP A 310
TRP A  32
TYR A  31
SER A  28
 None
 1.31A 5b6iB-3hgqA:
undetectable		 5b6iB-3hgqA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keh GLUCOCEREBROSIDASE

(Homo sapiens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 THR A 132
TYR A 133
THR A 134
SER A 125
 None
 1.29A 5b6iB-3kehA:
undetectable		 5b6iB-3kehA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mnz ANTI-HIV-1 ANTIBODY
13H11 LIGHT CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP A 170
THR A 172
TYR A 140
THR A 109
 None
 1.36A 5b6iB-3mnzA:
undetectable		 5b6iB-3mnzA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7t MACROPHAGE BINDING
PROTEIN

(Coccidioides
immitis) 		PF01965
(DJ-1_PfpI) 		4 ASP A 116
THR A  13
THR A  55
SER A  51
 None
 1.27A 5b6iB-3n7tA:
2.6		 5b6iB-3n7tA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntc FAB LIGHT CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP L 170
THR L 172
TYR L 140
THR L 109
 None
 1.29A 5b6iB-3ntcL:
undetectable		 5b6iB-3ntcL:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owa ACYL-COA
DEHYDROGENASE

(Bacillus
anthracis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 TRP A 183
THR A 232
THR A 234
SER A 187
 FAD  A 601 (-4.2A)
FAD  A 601 ( 3.9A)
None
None
 1.44A 5b6iB-3owaA:
undetectable		 5b6iB-3owaA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpx FAB C2507 LIGHT
CHAIN

(Homo sapiens;
Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP L 169
THR L 171
TYR L 139
THR L 108
 None
None
None
SO4  L 216 ( 2.9A)
 1.33A 5b6iB-3qpxL:
undetectable		 5b6iB-3qpxL:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrw THYLAKOID LUMENAL 29
KDA PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00141
(peroxidase) 		4 ASP A 158
THR A  45
TYR A  46
SER A  52
 CA  A 271 (-3.0A)
CA  A 271 (-4.0A)
None
None
 1.41A 5b6iB-3rrwA:
undetectable		 5b6iB-3rrwA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdp IRON SUPEROXIDE
DISMUTASE

(Pseudomonas
putida) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 TRP A  72
THR A  75
TYR A  77
THR A 154
 None
 1.32A 5b6iB-3sdpA:
undetectable		 5b6iB-3sdpA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Coxiella
burnetii) 		PF00551
(Formyl_trans_N) 		4 THR A 120
TYR A 119
THR A 124
SER A 114
 None
 1.25A 5b6iB-3tqrA:
2.2		 5b6iB-3tqrA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4b CH02 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP L 170
THR L 172
TYR L 140
THR L 109
 None
 1.33A 5b6iB-3u4bL:
undetectable		 5b6iB-3u4bL:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e54 DNA DAMAGE-BINDING
PROTEIN 2

(Homo sapiens) 		PF00400
(WD40) 		4 TRP B 270
THR B 260
THR B 266
SER B 262
 None
 1.40A 5b6iB-4e54B:
undetectable		 5b6iB-4e54B:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ht1 CHIMERIC ANTIBODY
FAB

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP L 174
THR L 176
TYR L 144
THR L 113
 None
 1.27A 5b6iB-4ht1L:
undetectable		 5b6iB-4ht1L:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jm4 PGT 135 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP L 170
THR L 172
TYR L 140
THR L 109
 None
 1.33A 5b6iB-4jm4L:
undetectable		 5b6iB-4jm4L:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzn ANTI-HCV E2 FAB
HC84-1 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP B 169
THR B 171
TYR B 139
THR B 108
 None
 1.30A 5b6iB-4jznB:
undetectable		 5b6iB-4jznB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4leb AGGLUTININ-LIKE
PROTEIN 3

(Candida
albicans) 		PF11766
(Candida_ALS_N) 		4 ASP A  68
THR A  70
TYR A  76
THR A 100
 None
 1.42A 5b6iB-4lebA:
undetectable		 5b6iB-4lebA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lix ENT-COPALYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ASP A 162
THR A 509
TYR A 511
THR A 114
 None
 1.18A 5b6iB-4lixA:
undetectable		 5b6iB-4lixA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1x GAMMA-HEMOLYSIN
COMPONENT C

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		4 THR B 103
TYR B 137
THR B 138
SER B 136
 None
 1.33A 5b6iB-4p1xB:
undetectable		 5b6iB-4p1xB:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8r GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC

(Trypanosoma
brucei) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ASP A 303
THR A 252
TYR A 253
SER A 300
 None
 1.15A 5b6iB-4p8rA:
undetectable		 5b6iB-4p8rA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r96 LLAMA GLAMA FAB 48A2
AGAINST HUMAN CMET L
CHAIN

(Lama glama) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP A 176
THR A 178
TYR A 146
THR A 115
 None
 1.38A 5b6iB-4r96A:
undetectable		 5b6iB-4r96A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase) 		4 ASP A 557
THR A 653
TYR A 652
SER A 561
 None
 1.26A 5b6iB-4ra7A:
undetectable		 5b6iB-4ra7A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uf7 GLYCOPROTEIN

(Ghanaian bat
henipavirus) 		PF00423
(HN) 		4 ASP A 520
THR A 572
THR A 239
SER A 574
 None
 1.36A 5b6iB-4uf7A:
undetectable		 5b6iB-4uf7A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xny LIGHT CHAIN OF
ANTIBODY VRC08C

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP L 170
THR L 172
TYR L 140
THR L 109
 None
 1.37A 5b6iB-4xnyL:
undetectable		 5b6iB-4xnyL:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydl LIGHT CHAIN OF
ANTIBODY
C38-VRC18.02

(Homo sapiens) 		no annotation 4 ASP L 170
THR L 172
TYR L 140
THR L 109
 None
None
None
NAG  L 301 (-4.5A)
 1.36A 5b6iB-4ydlL:
undetectable		 5b6iB-4ydlL:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydv HIV ANTIBODY 7B2
LIGHT CHAIN,IG KAPPA
CHAIN C REGION

(Homo sapiens) 		no annotation 4 ASP L 170
THR L 172
TYR L 140
THR L 109
 None
 1.41A 5b6iB-4ydvL:
undetectable		 5b6iB-4ydvL:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye4 LIGHT CHAIN OF HJ16

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP L 177
THR L 179
TYR L 147
THR L 116
 None
 1.36A 5b6iB-4ye4L:
undetectable		 5b6iB-4ye4L:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 THR A1003
TYR A1155
THR A 963
SER A1154
 None
 1.48A 5b6iB-4yswA:
undetectable		 5b6iB-4yswA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN

(Bordetella
bronchiseptica) 		PF03480
(DctP) 		4 ASP A 223
TRP A 217
TYR A 221
THR A  48
 None
 1.44A 5b6iB-4yzzA:
undetectable		 5b6iB-4yzzA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgf UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF16139
(DUF4847) 		4 ASP A  86
TRP A 102
THR A  88
THR A  82
 P6G  A 207 ( 4.8A)
None
P6G  A 207 (-4.0A)
P6G  A 205 ( 4.9A)
 1.47A 5b6iB-4zgfA:
undetectable		 5b6iB-4zgfA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TRP A 605
THR A 602
TYR A 606
THR A 607
 None
 1.19A 5b6iB-5a7mA:
undetectable		 5b6iB-5a7mA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ado FAB A.17

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP L 172
THR L 174
TYR L 142
THR L 111
 None
 1.35A 5b6iB-5adoL:
undetectable		 5b6iB-5adoL:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahv ANTH DOMAIN OF
ENDOCYTIC ADAPTOR
SLA2

(Saccharomyces
cerevisiae) 		PF07651
(ANTH) 		4 TRP F  36
THR F  35
TYR F  34
SER F  41
 None
 1.46A 5b6iB-5ahvF:
undetectable		 5b6iB-5ahvF:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1n MHC CLASS I ANTIGEN

(Canis lupus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ASP A 239
THR A 241
TYR A 210
THR A 179
 None
 1.21A 5b6iB-5f1nA:
undetectable		 5b6iB-5f1nA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4e BETA 1-3 GLUCANASE

(Clostridium
beijerinckii) 		no annotation 4 TRP A 555
TYR A 565
THR A 371
SER A 577
 None
 1.44A 5b6iB-5h4eA:
undetectable		 5b6iB-5h4eA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxw L-AMINO ACID
DEAMINASE

(Proteus
vulgaris) 		PF01266
(DAO) 		4 ASP A 202
THR A 132
TYR A 133
SER A 200
 None
 1.50A 5b6iB-5hxwA:
2.5		 5b6iB-5hxwA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris) 		PF01266
(DAO) 		4 ASP A 202
THR A 132
TYR A 133
SER A 200
 None
 1.49A 5b6iB-5i39A:
3.1		 5b6iB-5i39A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipy FLAVIN-CONTAINING
MONOOXYGENASE

(Roseovarius
nubinhibens) 		PF00743
(FMO-like) 		4 ASP A 334
TRP A 331
THR A 384
TYR A 386
 None
 1.46A 5b6iB-5ipyA:
2.6		 5b6iB-5ipyA:
21.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lmz FLUORINASE

(Streptomyces
sp. MA37) 		PF01887
(SAM_adeno_trans) 		6 ASP A  16
TRP A  50
THR A  76
TYR A  77
THR A  80
SER A 158
 None
None
None
CL  A 302 ( 4.6A)
None
None
 0.15A 5b6iB-5lmzA:
43.3		 5b6iB-5lmzA:
99.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbi DESIGN OF ANTIBODIES

(Escherichia
coli) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP L 174
THR L 176
TYR L 144
THR L 113
 None
 1.36A 5b6iB-5nbiL:
undetectable		 5b6iB-5nbiL:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5was HOMOSERINE KINASE

(Corynebacterium
glutamicum) 		no annotation 4 ASP A 139
THR A  28
THR A 154
SER A 152
 None
 1.47A 5b6iB-5wasA:
undetectable		 5b6iB-5wasA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y79 PUTATIVE HEXOSE
PHOSPHATE
TRANSLOCATOR

(Galdieria
sulphuraria) 		PF03151
(TPT) 		4 THR A 393
TYR A 396
THR A 230
SER A 397
 None
None
OLC  A 511 ( 4.8A)
None
 1.39A 5b6iB-5y79A:
undetectable		 5b6iB-5y79A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnk IGG1 KAPPA LIGHT
CHAIN

(Mus musculus) 		no annotation 4 ASP F 175
THR F 177
THR F 169
SER F 179
 None
 1.47A 5b6iB-6cnkF:
undetectable		 5b6iB-6cnkF:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE
HOLOENZYME TEB
HETEROTRIMER TEB3
SUBUNIT
TELOMERASE
HOLOENZYME TEB2
SUBUNIT

(Tetrahymena
thermophila) 		no annotation 4 ASP E  91
THR E  93
TYR F  10
THR F  27
 None
 1.43A 5b6iB-6d6vE:
undetectable		 5b6iB-6d6vE:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dnh PRE-MRNA 3' END
PROCESSING PROTEIN
WDR33

(Homo sapiens) 		no annotation 4 TRP B 229
THR B 219
THR B 225
SER B 221
 None
 1.33A 5b6iB-6dnhB:
undetectable		 5b6iB-6dnhB:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 4 ASP A 438
THR A 247
TYR A 248
THR A 243
 None
 1.47A 5b6iB-6gneA:
1.6		 5b6iB-6gneA:
undetectable