SIMILAR PATTERNS OF AMINO ACIDS FOR 5B6I_A_ADNA302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		4 ASP A 296
THR A 299
PRO A 230
THR A 269
 None
 0.87A 5b6iA-1cu1A:
undetectable		 5b6iA-1cu1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		4 ASP A 738
TRP A 736
THR A 404
SER A 457
 None
 1.34A 5b6iA-1d0nA:
undetectable		 5b6iA-1d0nA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6v CHIMERIC GERMLINE
PRECURSOR OF
OXY-COPE CATALYTIC
ANTIBODY AZ-28
(LIGHT CHAIN)

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP L 170
THR L 172
TYR L 140
THR L 109
 CD  L 502 ( 4.8A)
None
None
None
 1.30A 5b6iA-1d6vL:
undetectable		 5b6iA-1d6vL:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbi AK.1 SERINE PROTEASE

(Bacillus sp.
Ak1) 		PF00082
(Peptidase_S8) 		4 TRP A  24
PRO A  95
THR A  97
SER A 241
 None
 1.38A 5b6iA-1dbiA:
5.8		 5b6iA-1dbiA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1k ADRENODOXIN
REDUCTASE

(Bos taurus) 		PF07992
(Pyr_redox_2) 		4 THR A 379
TYR A  20
PRO A  16
SER A 383
 FAD  A 801 (-3.7A)
None
FAD  A 801 (-3.9A)
None
 1.37A 5b6iA-1e1kA:
2.3		 5b6iA-1e1kA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE

(Moorella
thermoacetica) 		PF01268
(FTHFS) 		4 ASP A1240
THR A1237
PRO A1235
THR A1230
 None
 1.29A 5b6iA-1eg7A:
undetectable		 5b6iA-1eg7A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ey2 HOMOGENTISATE
1,2-DIOXYGENASE

(Homo sapiens) 		PF04209
(HgmA) 		4 THR A  55
PRO A  52
THR A  50
SER A  47
 None
 1.35A 5b6iA-1ey2A:
undetectable		 5b6iA-1ey2A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ASP B 436
THR B 650
PRO B 652
THR B 481
 None
 0.98A 5b6iA-1ffvB:
undetectable		 5b6iA-1ffvB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g3p MINOR COAT PROTEIN

(Escherichia
virus M13) 		PF05357
(Phage_Coat_A) 		4 ASP A 107
THR A 109
TYR A 110
PRO A 111
 None
 1.30A 5b6iA-1g3pA:
undetectable		 5b6iA-1g3pA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gom ENDO-1,4-BETA-XYLANA
SE

(Thermoascus
aurantiacus) 		PF00331
(Glyco_hydro_10) 		4 TYR A 181
PRO A 182
THR A 184
SER A 178
 None
 1.28A 5b6iA-1gomA:
undetectable		 5b6iA-1gomA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji6 PESTICIDIAL CRYSTAL
PROTEIN CRY3BB

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 ASP A 425
THR A 440
TYR A 441
THR A 422
 None
 1.28A 5b6iA-1ji6A:
undetectable		 5b6iA-1ji6A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ASP B 439
THR B 656
PRO B 658
THR B 487
 None
 1.04A 5b6iA-1n60B:
undetectable		 5b6iA-1n60B:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL

(Homo sapiens) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 ASP A  73
TRP A  46
THR A  76
THR A  41
 None
 0.90A 5b6iA-1qk1A:
undetectable		 5b6iA-1qk1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rmg RHAMNOGALACTURONASE
A

(Aspergillus
aculeatus) 		PF00295
(Glyco_hydro_28) 		4 THR A 367
TYR A 369
THR A 370
SER A 352
 MAN  A 447 (-2.4A)
None
BMA  A 427 (-2.2A)
BMA  A 427 ( 4.3A)
 1.14A 5b6iA-1rmgA:
undetectable		 5b6iA-1rmgA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfj 3-DEHYDROQUINATE
DEHYDRATASE

(Staphylococcus
aureus) 		PF01487
(DHquinase_I) 		4 ASP A 102
THR A  68
TYR A  69
THR A  71
 None
DHK  A 239 ( 3.8A)
None
None
 1.00A 5b6iA-1sfjA:
undetectable		 5b6iA-1sfjA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6m GALACTOSE-BINDING
LECTIN

(Arachis
hypogaea) 		PF00139
(Lectin_legB) 		4 ASP A 136
THR A 124
TYR A 125
PRO A  81
 None
 1.35A 5b6iA-1v6mA:
undetectable		 5b6iA-1v6mA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aml SIS DOMAIN PROTEIN

(Listeria
monocytogenes) 		PF01380
(SIS) 		4 ASP A 301
THR A 304
TYR A 292
THR A 291
 None
 1.35A 5b6iA-2amlA:
2.0		 5b6iA-2amlA:
21.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE

(Streptomyces
cattleya) 		PF01887
(SAM_adeno_trans) 		7 ASP A  16
TRP A  50
THR A  76
TYR A  77
PRO A  78
THR A  80
SER A 158
 SA8  A1299 (-2.9A)
SA8  A1299 (-4.2A)
SA8  A1299 ( 4.7A)
None
SA8  A1299 (-4.4A)
SA8  A1299 (-4.0A)
SA8  A1299 (-2.6A)
 0.15A 5b6iA-2c4tA:
45.5		 5b6iA-2c4tA:
82.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cf5 CINNAMYL ALCOHOL
DEHYDROGENASE

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASP A 356
TRP A  13
THR A  11
TYR A  25
 None
 1.21A 5b6iA-2cf5A:
undetectable		 5b6iA-2cf5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dul N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF02005
(TRM) 		4 ASP A 323
THR A 360
PRO A 359
THR A 355
 None
 1.27A 5b6iA-2dulA:
undetectable		 5b6iA-2dulA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ets HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF08807
(DUF1798) 		4 THR A  34
TYR A  38
PRO A  37
THR A  39
 None
 1.18A 5b6iA-2etsA:
undetectable		 5b6iA-2etsA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5a PROTEIN (ANTIBODY
2F5 (LIGHT CHAIN))

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP L 170
THR L 172
TYR L 140
THR L 109
 None
 1.28A 5b6iA-2f5aL:
undetectable		 5b6iA-2f5aL:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 ASP A 162
THR A 159
PRO A 157
THR A 134
 None
 1.34A 5b6iA-2fmtA:
2.1		 5b6iA-2fmtA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE

(Aedes aegypti) 		PF00266
(Aminotran_5) 		4 ASP A 180
TRP A 105
THR A 151
SER A 184
 LLP  A 206 ( 2.9A)
LLP  A 206 ( 3.5A)
LLP  A 206 ( 4.6A)
None
 1.13A 5b6iA-2hufA:
undetectable		 5b6iA-2hufA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)

(Streptomyces
galilaeus) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 TRP A 325
THR A 229
PRO A 226
THR A 227
 None
 1.32A 5b6iA-2ipiA:
undetectable		 5b6iA-2ipiA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 TRP A1030
THR A1581
PRO A1029
THR A1191
 None
 1.19A 5b6iA-2pffA:
1.9		 5b6iA-2pffA:
11.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q6k CHLORINASE

(Salinispora
tropica) 		PF01887
(SAM_adeno_trans) 		4 ASP A  11
TYR A  72
PRO A  73
THR A  75
 ADN  A 699 (-2.9A)
None
ADN  A 699 (-4.0A)
ADN  A 699 (-3.4A)
 0.39A 5b6iA-2q6kA:
31.6		 5b6iA-2q6kA:
36.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkd ZINC FINGER PROTEIN
ZPR1

(Mus musculus) 		PF03367
(zf-ZPR1) 		4 THR A 330
PRO A 408
THR A 309
SER A 412
 None
 1.29A 5b6iA-2qkdA:
undetectable		 5b6iA-2qkdA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2g NON-STRUCTURAL
PROTEIN 3

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF11633
(SUD-M) 		4 ASP A 424
THR A 486
TYR A 487
PRO A 488
 None
 1.37A 5b6iA-2w2gA:
undetectable		 5b6iA-2w2gA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwu IMPORTIN13

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1) 		4 TRP B 364
THR B 430
TYR B 365
THR B 366
 None
 1.36A 5b6iA-2xwuB:
undetectable		 5b6iA-2xwuB:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egf EPIDERMAL GROWTH
FACTOR

(Mus musculus) 		PF00008
(EGF) 		4 ASP A  40
THR A  30
TYR A  29
SER A  28
 None
 1.29A 5b6iA-3egfA:
undetectable		 5b6iA-3egfA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN

(Streptococcus
agalactiae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 THR A 878
PRO A 879
THR A 883
SER A 871
 None
 1.37A 5b6iA-3fawA:
undetectable		 5b6iA-3fawA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnt HAP PROTEIN

(Plasmodium
falciparum) 		PF00026
(Asp) 		4 ASP A 290
THR A 225
PRO A 288
THR A 222
 None
 1.26A 5b6iA-3fntA:
undetectable		 5b6iA-3fntA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae) 		no annotation 4 THR A1278
PRO A1276
THR A1250
SER A1236
 None
 1.13A 5b6iA-3greA:
undetectable		 5b6iA-3greA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzg PERMEASE
MOLYBDATE-BINDING
PERIPLASMIC PROTEIN

(Xanthomonas
citri) 		PF13531
(SBP_bac_11) 		4 ASP A  53
THR A   6
PRO A   4
THR A  30
 None
 0.99A 5b6iA-3gzgA:
undetectable		 5b6iA-3gzgA:
29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgq HDA1 COMPLEX SUBUNIT
3

(Saccharomyces
cerevisiae) 		PF11496
(HDA2-3) 		4 ASP A 310
TRP A  32
TYR A  31
SER A  28
 None
 1.31A 5b6iA-3hgqA:
undetectable		 5b6iA-3hgqA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icv LIPASE B

(Moesziomyces
antarcticus) 		no annotation 4 THR A  96
TYR A  95
PRO A  67
SER A  90
 None
 1.01A 5b6iA-3icvA:
2.7		 5b6iA-3icvA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keh GLUCOCEREBROSIDASE

(Homo sapiens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 THR A 132
TYR A 133
THR A 134
SER A 125
 None
 1.29A 5b6iA-3kehA:
undetectable		 5b6iA-3kehA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2k EHPF

(Pantoea
agglomerans) 		PF00501
(AMP-binding) 		4 THR A 316
TYR A 324
PRO A 325
SER A 266
 None
 1.07A 5b6iA-3l2kA:
2.3		 5b6iA-3l2kA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lt3 POSSIBLE
MEMBRANE-ASSOCIATED
SERINE PROTEASE

(Mycobacterium
tuberculosis) 		PF13365
(Trypsin_2) 		4 THR A 303
TYR A 296
PRO A 297
THR A 221
 None
 1.35A 5b6iA-3lt3A:
undetectable		 5b6iA-3lt3A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mxl NITROSOSYNTHASE

(Micromonospora
sp. ATCC 39149) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ASP A  84
THR A  87
PRO A  41
THR A  39
 None
 1.30A 5b6iA-3mxlA:
undetectable		 5b6iA-3mxlA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7t MACROPHAGE BINDING
PROTEIN

(Coccidioides
immitis) 		PF01965
(DJ-1_PfpI) 		4 ASP A 116
THR A  13
THR A  55
SER A  51
 None
 1.26A 5b6iA-3n7tA:
undetectable		 5b6iA-3n7tA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmr CUGBP ELAV-LIKE
FAMILY MEMBER 1

(Homo sapiens) 		PF00076
(RRM_1) 		4 TRP A  27
THR A  26
PRO A  24
SER A  58
 None
 1.02A 5b6iA-3nmrA:
undetectable		 5b6iA-3nmrA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnh CUGBP ELAV-LIKE
FAMILY MEMBER 1

(Homo sapiens) 		PF00076
(RRM_1) 		4 TRP A  27
THR A  26
PRO A  24
SER A  58
 None
 1.09A 5b6iA-3nnhA:
undetectable		 5b6iA-3nnhA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE-LIK
E PROTEIN

(Homo sapiens) 		PF04389
(Peptidase_M28) 		4 ASP X 147
THR X 138
PRO X 145
THR X 141
 None
 1.13A 5b6iA-3pb9X:
undetectable		 5b6iA-3pb9X:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdd GLYCOSIDE HYDROLASE,
FAMILY 9

(Ruminiclostridium
thermocellum) 		no annotation 4 THR A  52
TYR A  51
PRO A  50
THR A  48
 CA  A 192 ( 4.9A)
None
CA  A 192 (-4.7A)
CA  A 192 (-3.8A)
 1.32A 5b6iA-3pddA:
undetectable		 5b6iA-3pddA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdg FIBRONECTIN(III)-LIK
E MODULE

(Ruminiclostridium
thermocellum) 		no annotation 4 THR A  52
TYR A  51
PRO A  50
THR A  48
 NA  A  99 ( 4.5A)
None
NA  A  99 (-4.3A)
None
 1.31A 5b6iA-3pdgA:
undetectable		 5b6iA-3pdgA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rq0 GLYCOSYL HYDROLASES
FAMILY PROTEIN 16

(Mycolicibacterium
smegmatis) 		PF00722
(Glyco_hydro_16) 		4 ASP A 257
TYR A 254
PRO A 255
THR A 253
 None
 1.32A 5b6iA-3rq0A:
undetectable		 5b6iA-3rq0A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdp IRON SUPEROXIDE
DISMUTASE

(Pseudomonas
putida) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 TRP A  72
THR A  75
TYR A  77
THR A 154
 None
 1.35A 5b6iA-3sdpA:
undetectable		 5b6iA-3sdpA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 TRP A 848
THR A 852
PRO A 849
SER A 287
 None
 1.19A 5b6iA-3sunA:
undetectable		 5b6iA-3sunA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Coxiella
burnetii) 		PF00551
(Formyl_trans_N) 		4 THR A 120
TYR A 119
THR A 124
SER A 114
 None
 1.26A 5b6iA-3tqrA:
1.8		 5b6iA-3tqrA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4b CH02 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP L 170
THR L 172
TYR L 140
THR L 109
 None
 1.35A 5b6iA-3u4bL:
undetectable		 5b6iA-3u4bL:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7v BETA-GALACTOSIDASE

(Caulobacter
vibrioides) 		PF02449
(Glyco_hydro_42) 		4 THR A 204
PRO A 299
THR A 300
SER A 295
 None
 0.94A 5b6iA-3u7vA:
undetectable		 5b6iA-3u7vA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 THR A1611
TYR A1612
PRO A1634
THR A1613
 None
None
BTI  A1901 (-4.6A)
None
 1.26A 5b6iA-3va7A:
undetectable		 5b6iA-3va7A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vhl DEDICATOR OF
CYTOKINESIS PROTEIN
8

(Mus musculus) 		PF06920
(DHR-2) 		4 THR A1897
TYR A1896
THR A1867
SER A1849
 None
 1.34A 5b6iA-3vhlA:
undetectable		 5b6iA-3vhlA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo9 VARIABLE LYMPHOCYTE
RECEPTOR C

(Lethenteron
camtschaticum) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 THR A  49
PRO A  47
THR A  43
SER A  40
 None
 1.22A 5b6iA-3wo9A:
undetectable		 5b6iA-3wo9A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		4 ASP A 114
PRO A  89
THR A  90
SER A  57
 None
 1.32A 5b6iA-3zg6A:
1.1		 5b6iA-3zg6A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9g CS6 FIMBRIAL SUBUNIT
B, CS6 FIMBRIAL
SUBUNIT A

(Escherichia
coli) 		PF16831
(CssAB) 		4 THR A 158
TYR A  39
PRO A  25
THR A  40
 None
 1.26A 5b6iA-4b9gA:
undetectable		 5b6iA-4b9gA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmo N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE

(Bacillus cereus) 		PF00797
(Acetyltransf_2) 		4 THR A  75
TYR A  77
PRO A  74
THR A 111
 None
 1.31A 5b6iA-4dmoA:
undetectable		 5b6iA-4dmoA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4goj PROTEIN UNC-119
HOMOLOG A

(Homo sapiens) 		PF05351
(GMP_PDE_delta) 		4 THR C 134
TYR C 236
PRO C 135
SER C 235
 None
 1.30A 5b6iA-4gojC:
undetectable		 5b6iA-4gojC:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il3 STE24P

(Saccharomyces
mikatae) 		PF01435
(Peptidase_M48)
PF16491
(Peptidase_M48_N) 		4 TYR A 432
PRO A 435
THR A 436
SER A 428
 None
 1.29A 5b6iA-4il3A:
undetectable		 5b6iA-4il3A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzn ANTI-HCV E2 FAB
HC84-1 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP B 169
THR B 171
TYR B 139
THR B 108
 None
 1.31A 5b6iA-4jznB:
undetectable		 5b6iA-4jznB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kwm HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 THR A 156
TYR A 157
PRO A 158
THR A 159
 None
 1.26A 5b6iA-4kwmA:
undetectable		 5b6iA-4kwmA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lix ENT-COPALYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ASP A 162
THR A 509
TYR A 511
THR A 114
 None
 1.20A 5b6iA-4lixA:
undetectable		 5b6iA-4lixA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mju NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 THR A 411
TYR A 281
PRO A 282
SER A 409
 None
 1.33A 5b6iA-4mjuA:
undetectable		 5b6iA-4mjuA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT

(Megavirus
chiliensis) 		no annotation 4 ASP B 105
THR B 101
TYR B 146
PRO B 100
 None
 1.22A 5b6iA-4p37B:
undetectable		 5b6iA-4p37B:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8r GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC

(Trypanosoma
brucei) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ASP A 303
THR A 252
TYR A 253
SER A 300
 None
 1.14A 5b6iA-4p8rA:
undetectable		 5b6iA-4p8rA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po4 LAMPETRA PLANERI
VLRC

(Lampetra
planeri) 		PF13855
(LRR_8) 		4 THR A  23
PRO A  21
THR A  17
SER A  14
 None
 1.27A 5b6iA-4po4A:
undetectable		 5b6iA-4po4A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C) 		4 THR A 750
TYR A 752
PRO A 749
THR A 747
 FAD  A 901 (-3.5A)
None
FAD  A 901 (-3.9A)
None
 1.37A 5b6iA-4qi4A:
undetectable		 5b6iA-4qi4A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase) 		4 ASP A 557
THR A 653
TYR A 652
SER A 561
 None
 1.27A 5b6iA-4ra7A:
undetectable		 5b6iA-4ra7A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3a ENDOGLUCANASE H

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		4 THR A 140
TYR A 139
PRO A 138
THR A 136
 None
 1.27A 5b6iA-4u3aA:
undetectable		 5b6iA-4u3aA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uf7 GLYCOPROTEIN

(Ghanaian bat
henipavirus) 		PF00423
(HN) 		4 ASP A 520
THR A 572
THR A 239
SER A 574
 None
 1.35A 5b6iA-4uf7A:
undetectable		 5b6iA-4uf7A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN

(Mycolicibacterium
fortuitum) 		PF00722
(Glyco_hydro_16) 		4 ASP A 270
TYR A 267
PRO A 268
THR A 266
 ASP  A 270 ( 0.5A)
TYR  A 267 ( 1.3A)
PRO  A 268 ( 1.1A)
THR  A 266 ( 0.8A)
 1.28A 5b6iA-4w65A:
undetectable		 5b6iA-4w65A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 4 ASP A 105
THR A 101
TYR A 146
PRO A 100
 None
 1.31A 5b6iA-4wseA:
undetectable		 5b6iA-4wseA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00659
(POLO_box) 		4 ASP A 540
THR A 543
PRO A 557
THR A 559
 None
 1.29A 5b6iA-4xb0A:
undetectable		 5b6iA-4xb0A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnq INFLUENZA H5 HA HEAD
DOMAIN VIETNAM RDT
MUTATIONS

(Influenza A
virus) 		no annotation 4 THR D 160
TYR D 161
PRO D 162
THR D 163
 None
 1.22A 5b6iA-4xnqD:
undetectable		 5b6iA-4xnqD:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvs DONOR 45 01DG5 COREE
GP120
VRC07_1995
45-VRC01.H01+07.O-86
3513/45-VRC01.L01+07
.O-110653 HEAVY
CHAIN

(Homo sapiens;
Human
immunodeficiency
virus 1) 		PF00516
(GP120)
PF07654
(C1-set)
PF07686
(V-set) 		4 ASP G 457
TYR H  60
PRO H  61
SER G 365
 None
 0.94A 5b6iA-4xvsG:
undetectable		 5b6iA-4xvsG:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yte H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ0715

(Methanocaldococcus
jannaschii) 		no annotation 4 THR A 117
PRO A 119
THR A 120
SER A 142
 None
 1.20A 5b6iA-4yteA:
undetectable		 5b6iA-4yteA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv7 LIPASE B

(Moesziomyces
antarcticus) 		no annotation 4 THR A  62
TYR A  61
PRO A  33
SER A  56
 None
 1.03A 5b6iA-4zv7A:
2.3		 5b6iA-4zv7A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TRP A 605
THR A 602
TYR A 606
THR A 607
 None
 1.18A 5b6iA-5a7mA:
undetectable		 5b6iA-5a7mA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ado FAB A.17

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP L 172
THR L 174
TYR L 142
THR L 111
 None
 1.37A 5b6iA-5adoL:
undetectable		 5b6iA-5adoL:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN

(Chaetomium
thermophilum) 		PF09439
(SRPRB) 		4 ASP B 146
THR B 147
PRO B 110
SER B 107
 GTP  B 402 ( 4.7A)
None
None
GTP  B 402 ( 2.3A)
 1.19A 5b6iA-5ck3B:
undetectable		 5b6iA-5ck3B:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3m ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2

(Lactobacillus
delbrueckii) 		PF00005
(ABC_tran) 		4 ASP B 210
THR B 269
PRO B 271
SER B 249
 None
 0.94A 5b6iA-5d3mB:
undetectable		 5b6iA-5d3mB:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1n MHC CLASS I ANTIGEN

(Canis lupus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ASP A 239
THR A 241
TYR A 210
THR A 179
 None
 1.22A 5b6iA-5f1nA:
undetectable		 5b6iA-5f1nA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsh CSM6

(Thermus
thermophilus) 		PF09670
(Cas_Cas02710) 		4 THR A  59
PRO A  61
THR A  64
SER A 134
 None
 1.22A 5b6iA-5fshA:
undetectable		 5b6iA-5fshA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hql RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 THR A 323
PRO A 366
THR A 364
SER A 310
 None
 1.23A 5b6iA-5hqlA:
undetectable		 5b6iA-5hqlA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i9q 3BNC55 FAB HEAVY
CHAIN
426C.TM4DV1-3 P120

(Homo sapiens;
Human
immunodeficiency
virus 1) 		PF00516
(GP120)
PF07654
(C1-set)
PF07686
(V-set) 		4 ASP A 457
TYR B  59
PRO B  60
SER A 364
 None
 0.99A 5b6iA-5i9qA:
undetectable		 5b6iA-5i9qA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jr4 TYPE 1 FIMBIRAL
ADHESIN FIMH

(Escherichia
coli) 		PF00419
(Fimbrial)
PF09160
(FimH_man-bind) 		4 ASP A  54
TYR A  48
PRO A  49
THR A  51
 GOL  A 301 (-3.3A)
None
None
None
 1.27A 5b6iA-5jr4A:
undetectable		 5b6iA-5jr4A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 4 ASP A 342
TYR A 291
PRO A 292
SER A 260
 CA  A 608 ( 2.9A)
None
CA  A 607 ( 4.8A)
CA  A 607 ( 3.9A)
 1.18A 5b6iA-5k8gA:
undetectable		 5b6iA-5k8gA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kan 16.G.07 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR I  97
TYR I  96
PRO I  95
THR I  93
 None
 1.36A 5b6iA-5kanI:
undetectable		 5b6iA-5kanI:
21.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lmz FLUORINASE

(Streptomyces
sp. MA37) 		PF01887
(SAM_adeno_trans) 		7 ASP A  16
TRP A  50
THR A  76
TYR A  77
PRO A  78
THR A  80
SER A 158
 None
None
None
CL  A 302 ( 4.6A)
CL  A 302 ( 3.7A)
None
None
 0.16A 5b6iA-5lmzA:
43.8		 5b6iA-5lmzA:
99.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6m APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00795
(CN_hydrolase) 		4 TRP A 217
THR A 475
TYR A 477
PRO A 164
 None
 1.33A 5b6iA-5n6mA:
undetectable		 5b6iA-5n6mA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nil MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Escherichia
coli) 		PF00005
(ABC_tran)
PF02687
(FtsX)
PF12704
(MacB_PCD) 		4 THR J 458
TYR J 456
PRO J 455
SER J 460
 None
 1.36A 5b6iA-5nilJ:
undetectable		 5b6iA-5nilJ:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B

(Methanothermobacter
sp. CaT2) 		PF00384
(Molybdopterin) 		4 THR B 301
TYR B 306
PRO B 307
SER B 304
 None
 1.16A 5b6iA-5t5iB:
undetectable		 5b6iA-5t5iB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj3 ALKALINE PHOSPHATASE
PAFA

(Elizabethkingia
meningoseptica) 		PF01663
(Phosphodiest) 		4 THR A 252
TYR A 251
PRO A 250
THR A 248
 None
 1.26A 5b6iA-5tj3A:
undetectable		 5b6iA-5tj3A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		4 ASP C 695
THR C 699
PRO C 697
SER C 612
 None
 1.34A 5b6iA-5tw1C:
undetectable		 5b6iA-5tw1C:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyt ICE-BINDING PROTEIN

(Flavobacteriaceae
bacterium
3519-10) 		no annotation 4 ASP A 313
THR A 332
PRO A 234
THR A 232
 None
 1.20A 5b6iA-5uytA:
undetectable		 5b6iA-5uytA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a0z HEMAGGLUTININ,ENVELO
PE GLYCOPROTEIN

(Human
immunodeficiency
virus 1;
Influenza A
virus) 		no annotation 4 THR A 160
TYR A 161
PRO A 162
THR A 163
 None
 1.32A 5b6iA-6a0zA:
undetectable		 5b6iA-6a0zA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dnh PRE-MRNA 3' END
PROCESSING PROTEIN
WDR33

(Homo sapiens) 		no annotation 4 TRP B 229
THR B 219
THR B 225
SER B 221
 None
 1.31A 5b6iA-6dnhB:
undetectable		 5b6iA-6dnhB:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esq HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Methanothermococcus
thermolithotrophicus) 		no annotation 4 ASP I 109
THR I  91
TYR I  86
PRO I  85
 None
 1.05A 5b6iA-6esqI:
undetectable		 5b6iA-6esqI:
12.62