SIMILAR PATTERNS OF AMINO ACIDS FOR 5B3S_G_CHDG102

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5s PENICILLIN G ACYLASE
BETA SUBUNIT

(Escherichia
coli) 		PF01804
(Penicil_amidase) 		5 PHE B 531
GLY B 532
MET B 485
GLU B 482
THR B 481
 None
 1.14A 5b3sG-1k5sB:
0.0
5b3sN-1k5sB:
0.3
5b3sO-1k5sB:
0.0		 5b3sG-1k5sB:
12.50
5b3sN-1k5sB:
20.53
5b3sO-1k5sB:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 5 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.37A 5b3sG-2quaA:
0.0
5b3sN-2quaA:
0.0
5b3sO-2quaA:
0.5		 5b3sG-2quaA:
9.09
5b3sN-2quaA:
21.91
5b3sO-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt7 TRNA
(URACIL-5-)-METHYLTR
ANSFERASE

(Escherichia
coli) 		PF05958
(tRNA_U5-meth_tr) 		5 ARG A 230
PHE A 224
GLY A 222
MET A 179
GLU A 170
 None
 1.37A 5b3sG-3bt7A:
0.0
5b3sN-3bt7A:
0.0
5b3sO-3bt7A:
0.0		 5b3sG-3bt7A:
13.92
5b3sN-3bt7A:
20.94
5b3sO-3bt7A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvr INVASION PLASMID
ANTIGEN

(Shigella
flexneri) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		5 ARG A 375
GLY A 484
MET A 402
GLY A 399
THR A 392
 None
 1.42A 5b3sG-3cvrA:
0.0
5b3sN-3cvrA:
0.2
5b3sO-3cvrA:
0.0		 5b3sG-3cvrA:
9.07
5b3sN-3cvrA:
22.78
5b3sO-3cvrA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgb UNCHARACTERIZED
PROTEIN Q89ZH8_BACTN

(Bacteroides
thetaiotaomicron) 		PF10282
(Lactonase) 		5 ARG A 112
PHE A 104
GLY A  83
GLY A 153
THR A 129
 None
 1.33A 5b3sG-3fgbA:
0.0
5b3sN-3fgbA:
undetectable
5b3sO-3fgbA:
0.0		 5b3sG-3fgbA:
13.33
5b3sN-3fgbA:
20.44
5b3sO-3fgbA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdj PROBABLE ORNITHINE
CYCLODEAMINASE

(Bordetella
pertussis) 		PF02423
(OCD_Mu_crystall) 		5 ARG A  41
ARG A  38
GLY A  53
GLY A 285
GLU A 233
 None
 1.24A 5b3sG-3hdjA:
0.0
5b3sN-3hdjA:
0.0
5b3sO-3hdjA:
0.0		 5b3sG-3hdjA:
12.86
5b3sN-3hdjA:
20.63
5b3sO-3hdjA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9b VIPERA RUSSELLI
PROTEINASE RVV-V
GAMMA

(Daboia
siamensis) 		PF00089
(Trypsin) 		5 ARG A 137
ARG A 135
PHE A 161
GLY A 184
GLY A  18
 None
 0.98A 5b3sG-3s9bA:
0.0
5b3sN-3s9bA:
undetectable
5b3sO-3s9bA:
0.1		 5b3sG-3s9bA:
15.53
5b3sN-3s9bA:
19.00
5b3sO-3s9bA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00155
(Aminotran_1_2) 		5 GLY A  94
GLY A 214
GLU A 201
THR A 230
THR A 231
 None
 1.39A 5b3sG-3wy7A:
0.0
5b3sN-3wy7A:
0.1
5b3sO-3wy7A:
0.0		 5b3sG-3wy7A:
12.93
5b3sN-3wy7A:
21.19
5b3sO-3wy7A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgy DNA TOPOISOMERASE
3-ALPHA

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 PHE A 559
GLY A 552
MET A 566
GLY A 565
THR A 544
 None
 1.35A 5b3sG-4cgyA:
0.0
5b3sN-4cgyA:
0.0
5b3sO-4cgyA:
0.0		 5b3sG-4cgyA:
9.36
5b3sN-4cgyA:
20.21
5b3sO-4cgyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu8 GLYCOSIDE HYDROLASE
2

(Streptococcus
pneumoniae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 PHE A 444
GLY A 643
GLY A 597
GLU A 505
THR A 482
 None
 1.35A 5b3sG-4cu8A:
undetectable
5b3sN-4cu8A:
0.0
5b3sO-4cu8A:
undetectable		 5b3sG-4cu8A:
7.93
5b3sN-4cu8A:
20.58
5b3sO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu8 GLYCOSIDE HYDROLASE
2

(Streptococcus
pneumoniae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 PHE A 444
GLY A 643
GLY A 597
THR A 482
THR A 483
 None
 1.48A 5b3sG-4cu8A:
undetectable
5b3sN-4cu8A:
0.0
5b3sO-4cu8A:
undetectable		 5b3sG-4cu8A:
7.93
5b3sN-4cu8A:
20.58
5b3sO-4cu8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9u TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKH

(Vibrio
parahaemolyticus) 		PF02386
(TrkH) 		5 PHE A 466
MET A 356
GLY A 355
THR A 110
THR A 112
 None
 1.37A 5b3sG-4j9uA:
undetectable
5b3sN-4j9uA:
0.7
5b3sO-4j9uA:
undetectable		 5b3sG-4j9uA:
10.92
5b3sN-4j9uA:
23.60
5b3sO-4j9uA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pel PENICILLIN G ACYLASE
SUBUNIT BETA

(Kluyvera
cryocrescens) 		PF01804
(Penicil_amidase) 		5 PHE B 531
GLY B 532
MET B 485
GLU B 482
THR B 481
 None
 1.23A 5b3sG-4pelB:
undetectable
5b3sN-4pelB:
undetectable
5b3sO-4pelB:
undetectable		 5b3sG-4pelB:
9.81
5b3sN-4pelB:
21.29
5b3sO-4pelB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdg PUTATIVE ADHESIN

(Bacteroides
thetaiotaomicron) 		PF08842
(Mfa2) 		5 ARG A 253
PHE A 119
GLY A 153
MET A 175
THR A  67
 None
 1.38A 5b3sG-4qdgA:
undetectable
5b3sN-4qdgA:
undetectable
5b3sO-4qdgA:
undetectable		 5b3sG-4qdgA:
13.97
5b3sN-4qdgA:
20.49
5b3sO-4qdgA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gq0 EPITHIOSPECIFIER
PROTEIN

(Arabidopsis
thaliana) 		no annotation 5 ARG B  94
PHE B 100
GLY B  92
GLY B  39
THR B  73
 None
 1.22A 5b3sG-5gq0B:
undetectable
5b3sN-5gq0B:
undetectable
5b3sO-5gq0B:
undetectable		 5b3sG-5gq0B:
12.46
5b3sN-5gq0B:
20.15
5b3sO-5gq0B:
18.62