SIMILAR PATTERNS OF AMINO ACIDS FOR 5B2T_A_ACTA108

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)

(Thermotoga
maritima) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		3 VAL A 123
THR A 328
ARG A 332
 None
 0.79A 5b2tB-1c3cA:
2.1		 5b2tB-1c3cA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e33 ARYLSULFATASE A

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		3 VAL P 326
THR P  60
ARG P  58
 None
 0.78A 5b2tB-1e33P:
undetectable		 5b2tB-1e33P:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 VAL A  52
THR A  54
ARG A 128
 None
 0.49A 5b2tB-1fcpA:
undetectable		 5b2tB-1fcpA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fyb PROTEINASE INHIBITOR

(Nicotiana alata) 		PF02428
(Prot_inhib_II) 		3 VAL A  82
THR A  80
ARG A 102
 None
 0.72A 5b2tB-1fybA:
undetectable		 5b2tB-1fybA:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gn1 CCT-GAMMA

(Mus musculus) 		PF00118
(Cpn60_TCP1) 		3 VAL A 343
THR A 345
ARG A 237
 None
 0.57A 5b2tB-1gn1A:
0.0		 5b2tB-1gn1A:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hng CD2

(Rattus rattus) 		PF05790
(C2-set)
PF07686
(V-set) 		3 VAL A  39
THR A  37
ARG A  34
 None
 0.61A 5b2tB-1hngA:
undetectable		 5b2tB-1hngA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hv6 ALGINATE LYASE

(Sphingomonas
sp.) 		PF05426
(Alginate_lyase) 		3 VAL A 159
THR A 161
ARG A 164
 None
 0.76A 5b2tB-1hv6A:
undetectable		 5b2tB-1hv6A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdp ATRIAL NATRIURETIC
PEPTIDE CLEARANCE
RECEPTOR

(Homo sapiens) 		PF01094
(ANF_receptor) 		3 VAL A 298
THR A  25
ARG A  26
 None
 0.78A 5b2tB-1jdpA:
2.3		 5b2tB-1jdpA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jye LACTOSE OPERON
REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		3 VAL A 324
THR A 288
ARG A 326
 None
 0.79A 5b2tB-1jyeA:
1.5		 5b2tB-1jyeA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ln1 PHOSPHATIDYLCHOLINE
TRANSFER PROTEIN

(Homo sapiens) 		PF01852
(START) 		3 VAL A  99
THR A  97
ARG A 118
 None
 0.66A 5b2tB-1ln1A:
undetectable		 5b2tB-1ln1A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n3p LECTIN PAL

(Pterocarpus
angolensis) 		PF00139
(Lectin_legB) 		3 VAL A 186
THR A 188
ARG A 194
 None
 0.64A 5b2tB-1n3pA:
undetectable		 5b2tB-1n3pA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pbj HYPOTHETICAL PROTEIN

(Methanothermobacter
thermautotrophicus) 		PF00571
(CBS) 		3 VAL A  11
THR A  13
ARG A  43
 None
 0.78A 5b2tB-1pbjA:
undetectable		 5b2tB-1pbjA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te5 CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF13230
(GATase_4) 		3 VAL A 221
THR A 193
ARG A 195
 None
 0.78A 5b2tB-1te5A:
undetectable		 5b2tB-1te5A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlf LAC REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		3 VAL A 324
THR A 288
ARG A 326
 None
 0.71A 5b2tB-1tlfA:
undetectable		 5b2tB-1tlfA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjz ENDOGLUCANASE

(Thermotoga
maritima) 		PF00150
(Cellulase) 		3 VAL A 271
THR A 266
ARG A 305
 None
 0.78A 5b2tB-1vjzA:
undetectable		 5b2tB-1vjzA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2l CYTOCHROME OXIDASE
SUBUNIT II

(Rhodothermus
marinus) 		PF00034
(Cytochrom_C) 		3 VAL A  69
THR A  43
ARG A  42
 HEM  A1100 ( 3.9A)
None
TRS  A1101 ( 2.0A)
 0.67A 5b2tB-1w2lA:
undetectable		 5b2tB-1w2lA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xss FLUORESCENT PROTEIN

(Favia favus) 		PF01353
(GFP) 		3 VAL A  24
THR A  26
ARG A  13
 None
 0.64A 5b2tB-1xssA:
undetectable		 5b2tB-1xssA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y2i HYPOTHETICAL PROTEIN
S0862

(Shigella
flexneri) 		PF01906
(YbjQ_1) 		3 VAL A  15
THR A  13
ARG A 106
 None
 0.78A 5b2tB-1y2iA:
undetectable		 5b2tB-1y2iA:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yoc HYPOTHETICAL PROTEIN
PA1835

(Pseudomonas
aeruginosa) 		PF14539
(DUF4442) 		3 VAL A  35
THR A  45
ARG A 104
 None
 0.73A 5b2tB-1yocA:
undetectable		 5b2tB-1yocA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC

(Homo sapiens) 		PF01063
(Aminotran_4) 		3 VAL A 102
THR A 154
ARG A 374
 None
 0.70A 5b2tB-2abjA:
undetectable		 5b2tB-2abjA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2acg PROFILIN II

(Acanthamoeba
castellanii) 		PF00235
(Profilin) 		3 VAL A  89
THR A  91
ARG A  75
 None
 0.79A 5b2tB-2acgA:
undetectable		 5b2tB-2acgA:
5.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsk VITAMIN B12
TRANSPORTER BTUB

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 VAL A  28
THR A  30
ARG A 106
 None
 0.68A 5b2tB-2gskA:
undetectable		 5b2tB-2gskA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0a TRANSCRIPTIONAL
REGULATOR

(Thermus
thermophilus) 		PF13377
(Peripla_BP_3) 		3 VAL A 329
THR A 292
ARG A 331
 None
 0.69A 5b2tB-2h0aA:
undetectable		 5b2tB-2h0aA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Neisseria
meningitidis) 		no annotation 3 VAL A 121
THR A  73
ARG A  97
 None
 0.78A 5b2tB-2kxiA:
undetectable		 5b2tB-2kxiA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lb5 SENSOR HISTIDINE
KINASE

(Synechococcus
sp.
JA-2-3B'a(2-13)) 		PF01590
(GAF) 		3 VAL A  65
THR A  63
ARG A  55
 None
 0.68A 5b2tB-2lb5A:
undetectable		 5b2tB-2lb5A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyc NUCLEAR PROTEIN SNF4

(Saccharomyces
cerevisiae) 		PF00571
(CBS) 		3 VAL A 307
THR A 309
ARG A 294
 None
 0.79A 5b2tB-2nycA:
undetectable		 5b2tB-2nycA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyk M157

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		3 VAL A 195
THR A 193
ARG A 260
 None
NAG  A 311 ( 4.9A)
None
 0.73A 5b2tB-2nykA:
undetectable		 5b2tB-2nykA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o26 MAST/STEM CELL
GROWTH FACTOR
RECEPTOR

(Mus musculus) 		no annotation 3 VAL X  76
THR X  70
ARG X  92
 None
 0.43A 5b2tB-2o26X:
undetectable		 5b2tB-2o26X:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paf LACTOSE OPERON
REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		3 VAL A 324
THR A 288
ARG A 326
 None
 0.76A 5b2tB-2pafA:
2.8		 5b2tB-2pafA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506

(Zoanthus sp.) 		PF01353
(GFP) 		3 VAL A  28
THR A  30
ARG A  17
 None
 0.75A 5b2tB-2pxsA:
undetectable		 5b2tB-2pxsA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ra5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00392
(GntR)
PF07702
(UTRA) 		3 VAL A 113
THR A 111
ARG A 133
 None
 0.68A 5b2tB-2ra5A:
undetectable		 5b2tB-2ra5A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 VAL A  28
THR A  26
ARG A   2
 None
 0.59A 5b2tB-2xf8A:
undetectable		 5b2tB-2xf8A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkk TOPOISOMERASE IV

(Acinetobacter
baumannii) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		3 VAL A1257
THR A1259
ARG A1300
 None
 0.55A 5b2tB-2xkkA:
0.4		 5b2tB-2xkkA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		3 VAL A 462
THR A 464
ARG A 471
 None
 0.58A 5b2tB-2xtlA:
undetectable		 5b2tB-2xtlA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwu IMPORTIN13

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1) 		3 VAL B 125
THR B 121
ARG B 122
 None
 0.74A 5b2tB-2xwuB:
undetectable		 5b2tB-2xwuB:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aup BASIC 7S GLOBULIN

(Glycine max) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		3 VAL A 327
THR A 384
ARG A 329
 None
 0.69A 5b2tB-3aupA:
undetectable		 5b2tB-3aupA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aux DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Methanocaldococcus
jannaschii) 		PF13476
(AAA_23) 		3 VAL A 909
THR A 911
ARG A 902
 None
 0.68A 5b2tB-3auxA:
undetectable		 5b2tB-3auxA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3k ALANINE RACEMASE

(Actinobacillus
succinogenes) 		PF13377
(Peripla_BP_3) 		3 VAL A 272
THR A 234
ARG A 274
 None
 0.75A 5b2tB-3c3kA:
undetectable		 5b2tB-3c3kA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb7 INSECTICIDAL
DELTA-ENDOTOXIN
CRY8EA1

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 VAL A 585
THR A 583
ARG A 580
 None
 0.65A 5b2tB-3eb7A:
1.8		 5b2tB-3eb7A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1t TYPE I SITE-SPECIFIC
RESTRICTION-MODIFICA
TION SYSTEM, R
(RESTRICTION)
SUBUNIT

(Vibrio
vulnificus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF13588
(HSDR_N_2) 		3 VAL A 526
THR A 558
ARG A 414
 None
 0.73A 5b2tB-3h1tA:
3.1		 5b2tB-3h1tA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6e CARBOHYDRATE KINASE,
FGGY

(Novosphingobium
aromaticivorans) 		PF00370
(FGGY_N) 		3 VAL A 269
THR A 267
ARG A 263
 None
 0.71A 5b2tB-3h6eA:
5.7		 5b2tB-3h6eA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 VAL B 486
THR B 541
ARG B 543
 None
 0.77A 5b2tB-3hhsB:
undetectable		 5b2tB-3hhsB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN US10

(Plasmodium
falciparum) 		PF00338
(Ribosomal_S10) 		3 VAL N  57
THR N  59
ARG N  82
 A  A1628 ( 3.8A)
G  A1732 ( 4.1A)
U  A1437 ( 3.2A)
 0.70A 5b2tB-3j7aN:
undetectable		 5b2tB-3j7aN:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0y PUTATIVE TOXIN
RELATED PROTEIN

(Parabacteroides
distasonis) 		PF12667
(NigD_N)
PF17415
(NigD_C) 		3 VAL A  43
THR A  41
ARG A  53
 None
 0.72A 5b2tB-3k0yA:
undetectable		 5b2tB-3k0yA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9c TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF13377
(Peripla_BP_3) 		3 VAL A 329
THR A 294
ARG A 331
 None
 0.79A 5b2tB-3k9cA:
2.4		 5b2tB-3k9cA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkx NASCENT
POLYPEPTIDE-ASSOCIAT
ED COMPLEX SUBUNIT
ALPHA

(Homo sapiens) 		PF01849
(NAC) 		3 VAL B  46
THR B  48
ARG B  34
 None
 0.74A 5b2tB-3lkxB:
undetectable		 5b2tB-3lkxB:
2.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loo ANOPHELES GAMBIAE
ADENOSINE KINASE

(Anopheles
gambiae) 		PF00294
(PfkB) 		3 VAL A 318
THR A 315
ARG A 314
 None
 0.69A 5b2tB-3looA:
undetectable		 5b2tB-3looA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mce NASCENT
POLYPEPTIDE-ASSOCIAT
ED COMPLEX SUBUNIT
ALPHA

(Homo sapiens) 		PF01849
(NAC) 		3 VAL A 105
THR A 107
ARG A  93
 None
 0.65A 5b2tB-3mceA:
undetectable		 5b2tB-3mceA:
3.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3miz PUTATIVE
TRANSCRIPTIONAL
REGULATOR PROTEIN,
LACI FAMILY

(Rhizobium etli) 		PF13377
(Peripla_BP_3) 		3 VAL A 331
THR A 294
ARG A 333
 None
 0.74A 5b2tB-3mizA:
undetectable		 5b2tB-3mizA:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Kosmotoga
olearia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 VAL A  17
THR A  33
ARG A  35
 None
 0.76A 5b2tB-3mwcA:
3.2		 5b2tB-3mwcA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p7m MALATE DEHYDROGENASE

(Francisella
tularensis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 VAL A  31
THR A  63
ARG A  61
 None
 0.79A 5b2tB-3p7mA:
4.0		 5b2tB-3p7mA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8a UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF13468
(Glyoxalase_3) 		3 VAL A 147
THR A 141
ARG A 139
 None
None
GOL  A 275 (-3.5A)
 0.80A 5b2tB-3p8aA:
undetectable		 5b2tB-3p8aA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4y THIAMIN
PYROPHOSPHOKINASE 1

(Homo sapiens) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		3 VAL A 226
THR A 228
ARG A 171
 None
 0.60A 5b2tB-3s4yA:
3.5		 5b2tB-3s4yA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tev GLYCOSYL HYROLASE,
FAMILY 3

(Deinococcus
radiodurans) 		PF00933
(Glyco_hydro_3) 		3 VAL A 295
THR A 299
ARG A 272
 None
 0.77A 5b2tB-3tevA:
undetectable		 5b2tB-3tevA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqi GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Coxiella
burnetii) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		3 VAL A 340
THR A 335
ARG A 376
 None
 0.45A 5b2tB-3tqiA:
2.8		 5b2tB-3tqiA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1j SERINE PROTEASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7) 		3 VAL B  57
THR B  59
ARG B  64
 None
 0.57A 5b2tB-3u1jB:
undetectable		 5b2tB-3u1jB:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubh NEURAL-CADHERIN

(Drosophila
melanogaster) 		PF00028
(Cadherin) 		3 VAL A 722
THR A 743
ARG A 745
 None
 0.74A 5b2tB-3ubhA:
undetectable		 5b2tB-3ubhA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v11 TRANSLATION
INITIATION FACTOR 2
SUBUNIT ALPHA

(Sulfolobus
solfataricus) 		PF00575
(S1)
PF07541
(EIF_2_alpha) 		3 VAL B 264
THR B 184
ARG B 226
 None
 0.61A 5b2tB-3v11B:
undetectable		 5b2tB-3v11B:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vql SMALL HEAT SHOCK
PROTEIN STHSP14.0

(Sulfurisphaera
tokodaii) 		PF00011
(HSP20) 		3 VAL A  37
THR A 109
ARG A 111
 None
 0.72A 5b2tB-3vqlA:
undetectable		 5b2tB-3vqlA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wi5 MAJOR OUTER MEMBRANE
PROTEIN P.IB

(Neisseria
meningitidis) 		PF00267
(Porin_1) 		3 VAL A  29
THR A  31
ARG A  17
 None
 0.77A 5b2tB-3wi5A:
undetectable		 5b2tB-3wi5A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdp NUCLEOCAPSID PROTEIN

(Influenza A
virus) 		PF00506
(Flu_NP) 		3 VAL A 155
THR A 151
ARG A 152
 None
 0.79A 5b2tB-3zdpA:
undetectable		 5b2tB-3zdpA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zta ANTI-SIGMA-FACTOR
ANTAGONIST (STAS)
DOMAIN PROTEIN

(Moorella
thermoacetica) 		no annotation 3 VAL A  13
THR A  37
ARG A  38
 None
 0.76A 5b2tB-3ztaA:
undetectable		 5b2tB-3ztaA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akz TYPE IV SECRETION
SYSTEM PROTEIN VIRB8

(Brucella suis) 		PF04335
(VirB8) 		3 VAL A 159
THR A 184
ARG A 186
 None
 0.76A 5b2tB-4akzA:
undetectable		 5b2tB-4akzA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4are COLLAGENASE G

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		3 VAL A 781
THR A 719
ARG A 721
 None
 0.76A 5b2tB-4areA:
2.4		 5b2tB-4areA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bj8 ZEBAVIDIN

(Danio rerio) 		PF01382
(Avidin) 		3 VAL A  11
THR A  19
ARG A  21
 None
 0.78A 5b2tB-4bj8A:
undetectable		 5b2tB-4bj8A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnd SYNTAXIN-10

(Homo sapiens) 		PF09177
(Syntaxin-6_N) 		3 VAL A  71
THR A  67
ARG A  88
 None
 0.59A 5b2tB-4dndA:
undetectable		 5b2tB-4dndA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f53 SUSD HOMOLOG

(Bacteroides
ovatus) 		PF12741
(SusD-like) 		3 VAL A 253
THR A 255
ARG A 364
 None
 0.62A 5b2tB-4f53A:
undetectable		 5b2tB-4f53A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffl PYLC

(Methanosarcina
barkeri) 		PF02655
(ATP-grasp_3) 		3 VAL A  28
THR A   3
ARG A  63
 None
 0.69A 5b2tB-4fflA:
undetectable		 5b2tB-4fflA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Saccharomyces
cerevisiae) 		PF03200
(Glyco_hydro_63)
PF16923
(Glyco_hydro_63N) 		3 VAL A 589
THR A 593
ARG A 523
 None
 0.72A 5b2tB-4j5tA:
undetectable		 5b2tB-4j5tA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		3 VAL B1260
THR B1262
ARG B1303
 None
 0.77A 5b2tB-4plbB:
undetectable		 5b2tB-4plbB:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2h PROLINE RACEMASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF05544
(Pro_racemase) 		3 VAL A 118
THR A 120
ARG A 129
 None
 0.78A 5b2tB-4q2hA:
undetectable		 5b2tB-4q2hA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		3 VAL A 589
THR A 591
ARG A 620
 None
 0.67A 5b2tB-4qjyA:
0.4		 5b2tB-4qjyA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Arthrobacter
sp. FB24) 		PF13377
(Peripla_BP_3) 		3 VAL A 336
THR A 296
ARG A 338
 None
 0.75A 5b2tB-4rkrA:
undetectable		 5b2tB-4rkrA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		3 VAL A 976
THR A 868
ARG A 870
 None
 0.78A 5b2tB-4u48A:
0.8		 5b2tB-4u48A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A

(Homo sapiens) 		PF00145
(DNA_methylase) 		3 VAL A 872
THR A 862
ARG A 866
 None
 0.72A 5b2tB-4u7tA:
undetectable		 5b2tB-4u7tA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upi SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		3 VAL A 369
THR A  44
ARG A  42
 None
 0.78A 5b2tB-4upiA:
undetectable		 5b2tB-4upiA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wab PROSTAGLANDIN E
SYNTHASE,LEUKOTRIENE
C4 SYNTHASE

(Homo sapiens) 		PF01124
(MAPEG) 		3 VAL A  65
THR A  34
ARG A  38
 None
 0.68A 5b2tB-4wabA:
undetectable		 5b2tB-4wabA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yco TRNA-DIHYDROURIDINE
SYNTHASE C

(Escherichia
coli) 		PF01207
(Dus) 		3 VAL A 136
THR A 163
ARG A 127
 None
 0.78A 5b2tB-4ycoA:
3.2		 5b2tB-4ycoA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yl0 PROSTAGLANDIN E
SYNTHASE

(Homo sapiens) 		PF01124
(MAPEG) 		3 VAL A  65
THR A  34
ARG A  38
 None
 0.71A 5b2tB-4yl0A:
2.1		 5b2tB-4yl0A:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdn DNA GYRASE SUBUNIT A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV) 		3 VAL A 260
THR A 262
ARG A 303
 VAL  A 260 ( 0.6A)
THR  A 262 ( 0.8A)
ARG  A 303 ( 0.6A)
 0.74A 5b2tB-5cdnA:
undetectable		 5b2tB-5cdnA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4s CONTACTIN-4

(Mus musculus) 		PF00041
(fn3) 		3 VAL A 717
THR A 719
ARG A 759
 None
 0.76A 5b2tB-5e4sA:
undetectable		 5b2tB-5e4sA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyy CENTROLOBIUM
TOMENTOSUM LECTIN

(Centrolobium
tomentosum) 		PF00139
(Lectin_legB) 		3 VAL A 187
THR A 189
ARG A 195
 None
 0.62A 5b2tB-5eyyA:
undetectable		 5b2tB-5eyyA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus musculus) 		PF05175
(MTS) 		3 VAL A 400
THR A 402
ARG A 339
 None
 0.59A 5b2tB-5fulA:
undetectable		 5b2tB-5fulA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT RRP4

(Saccharomyces
cerevisiae) 		PF14382
(ECR1_N)
PF15985
(KH_6) 		3 VAL H 224
THR H 222
ARG H 234
 None
 0.69A 5b2tB-5g06H:
3.2		 5b2tB-5g06H:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjy BETA-2-MICROGLOBULIN

(Anas
platyrhynchos) 		PF07654
(C1-set) 		3 VAL B  82
THR B  84
ARG B  99
 None
 0.67A 5b2tB-5gjyB:
undetectable		 5b2tB-5gjyB:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu7 PUTATIVE POLYKETIDE
SYNTHASE

(Brevibacillus
brevis) 		PF14765
(PS-DH) 		3 VAL A2978
THR A2980
ARG A3124
 None
 0.73A 5b2tB-5hu7A:
undetectable		 5b2tB-5hu7A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1w CRMK

(Actinoalloteichus
sp. WH1-2216-6) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 VAL A 170
THR A 172
ARG A  93
 None
 0.62A 5b2tB-5i1wA:
undetectable		 5b2tB-5i1wA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lvt DNA-BINDING PROTEIN
HU

(Lactococcus
lactis) 		no annotation 3 VAL A  77
THR A  75
ARG A  56
 None
 0.78A 5b2tB-5lvtA:
0.1		 5b2tB-5lvtA:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 VAL A2701
THR A2699
ARG A2694
 None
 0.74A 5b2tB-5nugA:
undetectable		 5b2tB-5nugA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 3 VAL A 197
THR A 199
ARG A 217
 None
 0.65A 5b2tB-5turA:
undetectable		 5b2tB-5turA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Brucella canis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 VAL A 448
THR A 450
ARG A 455
 None
 0.59A 5b2tB-5u2aA:
undetectable		 5b2tB-5u2aA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7n CYTOCHROME C OXIDASE
SUBUNIT 2

(Thermus
thermophilus) 		no annotation 3 VAL A 104
THR A 134
ARG A 136
 None
 0.75A 5b2tB-5u7nA:
undetectable		 5b2tB-5u7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s CELL DIVISION
CONTROL PROTEIN 45

(Saccharomyces
cerevisiae) 		PF02724
(CDC45) 		3 VAL E 410
THR E 412
ARG E 330
 None
 0.76A 5b2tB-5u8sE:
0.0		 5b2tB-5u8sE:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufh LACI-TYPE
TRANSCRIPTIONAL
REGULATOR

(Bifidobacterium
animalis) 		PF13377
(Peripla_BP_3) 		3 VAL A 337
THR A 300
ARG A 339
 None
 0.75A 5b2tB-5ufhA:
undetectable		 5b2tB-5ufhA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5y UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF03739
(YjgP_YjgQ) 		3 VAL G 203
THR G 205
ARG G 173
 None
 0.52A 5b2tB-5x5yG:
2.4		 5b2tB-5x5yG:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER

(Homo sapiens) 		no annotation 3 VAL A 715
THR A 719
ARG A 636
 None
 0.70A 5b2tB-5zalA:
2.3		 5b2tB-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A

(Homo sapiens) 		no annotation 3 VAL A 872
THR A 862
ARG A 866
 None
 0.75A 5b2tB-6brrA:
undetectable		 5b2tB-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhw GLUCOAMYLASE P

(Amorphotheca
resinae) 		no annotation 3 VAL A 331
THR A 312
ARG A 316
 None
 0.77A 5b2tB-6fhwA:
2.3		 5b2tB-6fhwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fmq -

(-) 		no annotation 3 VAL A 547
THR A 545
ARG A 536
 None
 0.79A 5b2tB-6fmqA:
undetectable		 5b2tB-6fmqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gy5 -

(-) 		no annotation 3 VAL A 443
THR A 441
ARG A 432
 None
None
EDO  A 703 (-3.0A)
 0.77A 5b2tB-6gy5A:
undetectable		 5b2tB-6gy5A:
undetectable