SIMILAR PATTERNS OF AMINO ACIDS FOR 5B2Q_A_ACTA1728_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad6 RETINOBLASTOMA TUMOR
SUPPRESSOR

(Homo sapiens) 		PF01858
(RB_A) 		3 ASN A 505
SER A 503
ARG A 500
 None
 0.60A 5b2qA-1ad6A:
undetectable		 5b2qA-1ad6A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c1f PROTEIN (CONGERIN I)

(Conger
myriaster) 		PF00337
(Gal-bind_lectin) 		3 ASN A  33
SER A  31
ARG A  29
 None
 0.92A 5b2qA-1c1fA:
0.1		 5b2qA-1c1fA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci9 PROTEIN
(CARBOXYLESTERASE)

(Burkholderia
gladioli) 		PF00144
(Beta-lactamase) 		3 ASN A 162
SER A 149
ARG A 263
 None
 0.94A 5b2qA-1ci9A:
undetectable		 5b2qA-1ci9A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1io0 TROPOMODULIN

(Gallus gallus) 		no annotation 3 ASN A 203
SER A 230
ARG A 286
 None
 0.74A 5b2qA-1io0A:
undetectable		 5b2qA-1io0A:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jiu DNA
BETA-GLUCOSYLTRANSFE
RASE

(Escherichia
virus T4) 		PF09198
(T4-Gluco-transf) 		3 ASN A  70
SER A  68
ARG A 102
 None
 0.94A 5b2qA-1jiuA:
0.0		 5b2qA-1jiuA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmz AMINE DEHYDROGENASE

(Pseudomonas
putida) 		no annotation 3 ASN B  82
SER B  84
ARG B  92
 None
 0.93A 5b2qA-1jmzB:
0.9		 5b2qA-1jmzB:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krm ADENOSINE DEAMINASE

(Bos taurus) 		PF00962
(A_deaminase) 		3 ASN A 290
SER A 288
ARG A 232
 None
 0.94A 5b2qA-1krmA:
1.0		 5b2qA-1krmA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npb FOSFOMYCIN-RESISTANC
E PROTEIN

(Serratia
marcescens) 		PF00903
(Glyoxalase) 		3 ASN A  95
SER A  97
ARG A 122
 None
SO4  A 402 ( 3.9A)
SO4  A 403 ( 3.4A)
 0.86A 5b2qA-1npbA:
1.2		 5b2qA-1npbA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrw HYPOTHETICAL
PROTEIN, HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacillus
subtilis) 		PF08282
(Hydrolase_3) 		3 ASN A 204
SER A 200
ARG A  43
 None
PO4  A 900 ( 4.2A)
None
 0.95A 5b2qA-1nrwA:
0.4		 5b2qA-1nrwA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4t OUTER MEMBRANE
PROTEIN NSPA

(Neisseria
meningitidis) 		PF02462
(Opacity) 		3 ASN A  89
SER A  87
ARG A 129
 None
 0.97A 5b2qA-1p4tA:
0.0		 5b2qA-1p4tA:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Streptomyces
sp. R61) 		PF00144
(Beta-lactamase) 		3 ASN A 161
SER A  62
ARG A 285
 2PB  A 400 ( 3.6A)
2PB  A 400 (-1.6A)
2PB  A 400 (-3.9A)
 0.91A 5b2qA-1sdeA:
undetectable		 5b2qA-1sdeA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0k GENE PRODUCT PA4716

(Pseudomonas
aeruginosa) 		PF02567
(PhzC-PhzF) 		3 ASN A 148
SER A 146
ARG A 176
 None
 0.76A 5b2qA-1u0kA:
undetectable		 5b2qA-1u0kA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uio ADENOSINE DEAMINASE

(Mus musculus) 		PF00962
(A_deaminase) 		3 ASN A 293
SER A 291
ARG A 235
 None
 0.83A 5b2qA-1uioA:
undetectable		 5b2qA-1uioA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uis RED FLUORESCENT
PROTEIN FP611

(Entacmaea
quadricolor) 		PF01353
(GFP) 		3 ASN A 143
SER A 158
ARG A  92
 NRQ  A  63 ( 3.1A)
NRQ  A  63 ( 2.4A)
NRQ  A  63 ( 3.1A)
 0.94A 5b2qA-1uisA:
undetectable		 5b2qA-1uisA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6u ENDO-1,4-BETA-D-XYLA
NASE

(Streptomyces
olivaceoviridis) 		PF00331
(Glyco_hydro_10)
PF00652
(Ricin_B_lectin) 		3 ASN A 173
SER A 212
ARG A 275
 XYP  A 457 (-3.4A)
XYP  A 457 (-3.1A)
XYP  A 457 ( 3.2A)
 0.73A 5b2qA-1v6uA:
1.2		 5b2qA-1v6uA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlc CONGERIN II

(Conger
myriaster) 		PF00337
(Gal-bind_lectin) 		3 ASN A  33
SER A  31
ARG A  29
 MES  A 777 ( 3.9A)
MES  A 777 ( 4.0A)
None
 0.92A 5b2qA-1wlcA:
undetectable		 5b2qA-1wlcA:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnt PROTEIN (DNA-REPAIR
PROTEIN XRCC1)

(Homo sapiens) 		PF01834
(XRCC1_N) 		3 ASN A 106
SER A 145
ARG A  34
 None
 0.70A 5b2qA-1xntA:
undetectable		 5b2qA-1xntA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buk COAT PROTEIN

(unidentified
tobacco
necrosis virus) 		PF03898
(TNV_CP) 		3 ASN A 148
SER A  69
ARG A  28
 None
 0.78A 5b2qA-2bukA:
undetectable		 5b2qA-2bukA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fxf DIAMINE
ACETYLTRANSFERASE 1

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		3 ASN A 133
SER A 136
ARG A 101
 ACO  A1000 ( 3.1A)
ACO  A1000 (-2.6A)
ACO  A1000 (-3.7A)
 0.72A 5b2qA-2fxfA:
undetectable		 5b2qA-2fxfA:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h9f HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF04303
(PrpF) 		3 ASN A 103
SER A 108
ARG A 378
 None
 0.84A 5b2qA-2h9fA:
undetectable		 5b2qA-2h9fA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i54 PHOSPHOMANNOMUTASE

(Leishmania
mexicana) 		PF03332
(PMM) 		3 ASN A 127
SER A 178
ARG A 140
 CIT  A3001 ( 4.5A)
CIT  A3001 (-3.0A)
CIT  A3001 (-3.8A)
 0.76A 5b2qA-2i54A:
undetectable		 5b2qA-2i54A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nli LACTATE OXIDASE

(Aerococcus
viridans) 		PF01070
(FMN_dh) 		3 ASN A 264
SER A 297
ARG A 320
 None
FMN  A1375 (-4.0A)
FMN  A1375 (-3.9A)
 0.96A 5b2qA-2nliA:
undetectable		 5b2qA-2nliA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omv INTERNALIN-A

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		3 ASN A 128
SER A 106
ARG A  85
 None
 0.95A 5b2qA-2omvA:
undetectable		 5b2qA-2omvA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjw UNCHARACTERIZED
PROTEIN YHL002W
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 27

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		3 ASN H 307
SER H 310
ARG V 426
 None
 0.92A 5b2qA-2pjwH:
2.4		 5b2qA-2pjwH:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfe CALPAIN-7

(Homo sapiens) 		PF01067
(Calpain_III) 		3 ASN A 802
SER A 689
ARG A 691
 None
None
BR  A   4 (-3.2A)
 0.96A 5b2qA-2qfeA:
undetectable		 5b2qA-2qfeA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri8 MANNOSYL-OLIGOSACCHA
RIDE
ALPHA-1,2-MANNOSIDAS
E

(Penicillium
citrinum) 		PF01532
(Glyco_hydro_47) 		3 ASN A1366
SER A1367
ARG A1309
 NAG  A1700 (-1.9A)
None
NAG  A1701 (-4.3A)
 0.97A 5b2qA-2ri8A:
0.0		 5b2qA-2ri8A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tdd THYMIDYLATE SYNTHASE

(Lactobacillus
casei) 		PF00303
(Thymidylat_synt) 		3 ASN A 207
SER A 212
ARG A  37
 None
 0.93A 5b2qA-2tddA:
2.3		 5b2qA-2tddA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		3 ASN A 244
SER A 248
ARG A 295
 None
 0.69A 5b2qA-2vcaA:
2.3		 5b2qA-2vcaA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsa MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		3 ASN A 231
SER A 233
ARG A 310
 None
 0.91A 5b2qA-2vsaA:
undetectable		 5b2qA-2vsaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a79 TOLL-LIKE RECEPTOR
6, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		3 ASN B 359
SER B 339
ARG B 386
 NAG  B 951 (-1.7A)
NAG  B 951 (-3.3A)
NAG  B 952 (-3.1A)
 0.86A 5b2qA-3a79B:
undetectable		 5b2qA-3a79B:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajy ANCESTRAL CONGERIN
CON-ANC

(-) 		PF00337
(Gal-bind_lectin) 		3 ASN A  33
SER A  31
ARG A  29
 None
None
GAL  A 136 (-2.9A)
 0.78A 5b2qA-3ajyA:
undetectable		 5b2qA-3ajyA:
5.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajz ANCESTRAL CONGERIN
CON-ANC

(-) 		PF00337
(Gal-bind_lectin) 		3 ASN A  31
SER A  29
ARG A  27
 None
None
GAL  A 133 (-2.9A)
 0.95A 5b2qA-3ajzA:
undetectable		 5b2qA-3ajzA:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bln ACETYLTRANSFERASE
GNAT FAMILY

(Bacillus cereus) 		PF00583
(Acetyltransf_1) 		3 ASN A 115
SER A  82
ARG A  78
 None
 0.95A 5b2qA-3blnA:
undetectable		 5b2qA-3blnA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cij UPF0100 PROTEIN
AF_0094

(Archaeoglobus
fulgidus) 		PF13531
(SBP_bac_11) 		3 ASN A 149
SER A 202
ARG A  75
 None
 0.78A 5b2qA-3cijA:
undetectable		 5b2qA-3cijA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN
POLYPROTEIN

(Senecavirus A;
Senecavirus A) 		no annotation
PF00073
(Rhv) 		3 ASN B 107
SER B 106
ARG A 255
 None
 0.97A 5b2qA-3cjiB:
undetectable		 5b2qA-3cjiB:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckb SUSD

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB) 		3 ASN A 233
SER A 497
ARG A 494
 None
 0.82A 5b2qA-3ckbA:
undetectable		 5b2qA-3ckbA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clq UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF06545
(DUF1116) 		3 ASN A 173
SER A  77
ARG A  73
 None
 0.88A 5b2qA-3clqA:
0.0		 5b2qA-3clqA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwk PENICILLIN-BINDING
PROTEIN 2

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		3 ASN A 235
SER A 198
ARG A 288
 None
 0.89A 5b2qA-3dwkA:
undetectable		 5b2qA-3dwkA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		3 ASN A 774
SER A 771
ARG A 743
 None
 0.96A 5b2qA-3ecqA:
undetectable		 5b2qA-3ecqA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewd ADENOSINE DEAMINASE

(Plasmodium
vivax) 		PF00962
(A_deaminase) 		3 ASN A 307
SER A 305
ARG A 249
 None
 0.82A 5b2qA-3ewdA:
1.2		 5b2qA-3ewdA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9r PHOSPHOMANNOMUTASE

(Trypanosoma
brucei) 		PF03332
(PMM) 		3 ASN A 127
SER A 178
ARG A 140
 SO4  A 247 ( 4.8A)
SO4  A 247 ( 3.7A)
SO4  A 247 (-3.6A)
 0.67A 5b2qA-3f9rA:
undetectable		 5b2qA-3f9rA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 ASN A 813
SER A 452
ARG A 240
 None
 0.96A 5b2qA-3hhdA:
undetectable		 5b2qA-3hhdA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3w PHOSPHOGLUCOSAMINE
MUTASE

(Francisella
tularensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 ASN A 116
SER A 114
ARG A 306
 None
 0.72A 5b2qA-3i3wA:
undetectable		 5b2qA-3i3wA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijt PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		no annotation 3 ASN A  91
SER A  97
ARG A  99
 None
 0.90A 5b2qA-3ijtA:
undetectable		 5b2qA-3ijtA:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyj MAJOR CAPSID PROTEIN
L1

(Deltapapillomavirus
4) 		no annotation 3 ASN F 317
SER F  23
ARG F  29
 None
 0.94A 5b2qA-3iyjF:
undetectable		 5b2qA-3iyjF:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kio RIBONUCLEASE H2
SUBUNIT A

(Mus musculus) 		PF01351
(RNase_HII) 		3 ASN A 113
SER A 116
ARG A 153
 None
 0.89A 5b2qA-3kioA:
2.7		 5b2qA-3kioA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		3 ASN A 736
SER A 759
ARG A 862
 None
 0.90A 5b2qA-3lltA:
undetectable		 5b2qA-3lltA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lul 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Legionella
pneumophila) 		PF01063
(Aminotran_4) 		3 ASN A  35
SER A  40
ARG A 204
 None
 0.75A 5b2qA-3lulA:
undetectable		 5b2qA-3lulA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvd REGULATOR OF
CHROMOSOME
CONDENSATION

(Drosophila
melanogaster) 		PF00415
(RCC1) 		3 ASN K 159
SER K 152
ARG K 169
 None
 0.93A 5b2qA-3mvdK:
undetectable		 5b2qA-3mvdK:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvd REGULATOR OF
CHROMOSOME
CONDENSATION

(Drosophila
melanogaster) 		PF00415
(RCC1) 		3 ASN K 167
SER K 152
ARG K 154
 None
 0.59A 5b2qA-3mvdK:
undetectable		 5b2qA-3mvdK:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		3 ASN A 574
SER A 875
ARG A 613
 None
 0.94A 5b2qA-3o8oA:
undetectable		 5b2qA-3o8oA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oy2 GLYCOSYLTRANSFERASE
B736L

(Paramecium
bursaria
Chlorella virus
NY2A) 		no annotation 3 ASN A 279
SER A 281
ARG A 196
 None
 0.82A 5b2qA-3oy2A:
undetectable		 5b2qA-3oy2A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p13 D-RIBOSE PYRANASE

(Staphylococcus
aureus) 		PF05025
(RbsD_FucU) 		3 ASN A  79
SER A 126
ARG A  52
 None
 0.68A 5b2qA-3p13A:
undetectable		 5b2qA-3p13A:
6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p56 RIBONUCLEASE H2
SUBUNIT A

(Homo sapiens) 		PF01351
(RNase_HII) 		3 ASN A 112
SER A 115
ARG A 152
 None
 0.70A 5b2qA-3p56A:
2.9		 5b2qA-3p56A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		3 ASN A 117
SER A 119
ARG A  84
 COA  A 201 (-3.3A)
COA  A 201 (-3.8A)
COA  A 201 (-3.9A)
 0.83A 5b2qA-3tfyA:
undetectable		 5b2qA-3tfyA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkn NUCLEOPORIN NUP82
NUCLEOPORIN 98

(Saccharomyces
cerevisiae;
Mus musculus) 		no annotation
PF04096
(Nucleoporin2) 		3 ASN A 170
SER A 172
ARG C 795
 None
 0.92A 5b2qA-3tknA:
undetectable		 5b2qA-3tknA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		3 ASN A 617
SER A 621
ARG A 625
 None
 0.89A 5b2qA-3ua4A:
4.6		 5b2qA-3ua4A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umg HALOACID
DEHALOGENASE

(Rhodococcus
jostii) 		PF00702
(Hydrolase) 		3 ASN A  85
SER A  64
ARG A  73
 None
 0.94A 5b2qA-3umgA:
undetectable		 5b2qA-3umgA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3s TYPE-2 SERINE--TRNA
LIGASE

(Methanopyrus
kandleri) 		PF00587
(tRNA-synt_2b) 		3 ASN A 454
SER A 452
ARG A 366
 SSA  A2002 (-4.3A)
SSA  A2002 (-2.9A)
SSA  A2002 (-3.0A)
 0.77A 5b2qA-3w3sA:
undetectable		 5b2qA-3w3sA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3won DIPEPTIDYL
AMINOPEPTIDASE BII

(Pseudoxanthomonas
mexicana) 		PF10459
(Peptidase_S46) 		3 ASN A 576
SER A 578
ARG A 186
 None
 0.89A 5b2qA-3wonA:
undetectable		 5b2qA-3wonA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aqq L2 PROTEIN III
(PENTON BASE)

(Human
mastadenovirus
B) 		PF01686
(Adeno_Penton_B) 		3 ASN A 366
SER A 213
ARG A 151
 None
 0.86A 5b2qA-4aqqA:
undetectable		 5b2qA-4aqqA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bws THIOREDOXIN-LIKE
PROTEIN 4A
POLYGLUTAMINE-BINDIN
G PROTEIN 1

(Homo sapiens;
Homo sapiens) 		PF02966
(DIM1)
no annotation 		3 ASN A  87
SER B 247
ARG B 253
 None
 0.73A 5b2qA-4bwsA:
undetectable		 5b2qA-4bwsA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cdo THIOREDOXIN-LIKE
PROTEIN 4A,
POLYGLUTAMINE-BINDIN
G PROTEIN

(Homo sapiens) 		PF02966
(DIM1) 		3 ASN A  87
SER A 247
ARG A 253
 None
 0.81A 5b2qA-4cdoA:
undetectable		 5b2qA-4cdoA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica) 		PF00291
(PALP) 		3 ASN A 305
SER A 187
ARG A  33
 None
 0.87A 5b2qA-4d8uA:
2.8		 5b2qA-4d8uA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA

(Brucella
abortus) 		PF00677
(Lum_binding) 		3 ASN A 184
SER A  44
ARG A  84
 None
 0.89A 5b2qA-4e0fA:
undetectable		 5b2qA-4e0fA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		3 ASN W 697
SER W 209
ARG W 237
 None
 0.93A 5b2qA-4f5xW:
undetectable		 5b2qA-4f5xW:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g59 RETINOIC ACID
EARLY-INDUCIBLE
PROTEIN 1-GAMMA

(Mus musculus) 		PF14586
(MHC_I_2) 		3 ASN A 126
SER A 128
ARG A 130
 None
 0.94A 5b2qA-4g59A:
undetectable		 5b2qA-4g59A:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hac MEVALONATE KINASE

(Methanosarcina
mazei) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 ASN A 235
SER A 240
ARG A 247
 None
 0.96A 5b2qA-4hacA:
1.8		 5b2qA-4hacA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjh PHOSPHOMANNOMUTASE

(Brucella
melitensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 ASN A 440
SER A  11
ARG A 346
 G6Q  A 544 ( 3.6A)
G6Q  A 544 (-2.4A)
SEP  A 104 ( 2.9A)
 0.95A 5b2qA-4hjhA:
2.2		 5b2qA-4hjhA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		3 ASN A 286
SER A 290
ARG A 299
 None
 0.95A 5b2qA-4je5A:
undetectable		 5b2qA-4je5A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l83 UBE2I2 PROTEIN

(Brugia malayi) 		PF00179
(UQ_con) 		3 ASN A  38
SER A  30
ARG A  62
 None
 0.95A 5b2qA-4l83A:
undetectable		 5b2qA-4l83A:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oa7 TANKYRASE-1

(Homo sapiens) 		PF00644
(PARP) 		3 ASN A1178
SER A1259
ARG A1281
 None
 0.83A 5b2qA-4oa7A:
undetectable		 5b2qA-4oa7A:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		3 ASN A 234
SER A 233
ARG A 229
 None
 0.93A 5b2qA-4r04A:
undetectable		 5b2qA-4r04A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r33 NOSL

(Streptomyces
actuosus) 		PF06968
(BATS) 		3 ASN A 246
SER A 281
ARG A 323
 None
TRP  A 503 ( 4.9A)
TRP  A 503 ( 2.9A)
 0.92A 5b2qA-4r33A:
undetectable		 5b2qA-4r33A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT

(Pseudomonas
mendocina) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 ASN A  37
SER A  23
ARG A 102
 None
 0.87A 5b2qA-4wqmA:
undetectable		 5b2qA-4wqmA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgh CITRATE SYNTHASE

(Burkholderia
thailandensis) 		PF00285
(Citrate_synt) 		3 ASN A 273
SER A 371
ARG A 319
 EDO  A 509 (-3.4A)
None
SO4  A 502 (-3.1A)
 0.90A 5b2qA-4xghA:
undetectable		 5b2qA-4xghA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yrd CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP5F

(Staphylococcus
aureus) 		PF01370
(Epimerase) 		3 ASN A 277
SER A 279
ARG A 259
 3IT  A 402 ( 4.2A)
None
None
 0.66A 5b2qA-4yrdA:
undetectable		 5b2qA-4yrdA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgc KELCH PROTEIN

(Plasmodium
falciparum) 		PF01344
(Kelch_1)
PF02214
(BTB_2)
PF13418
(Kelch_4) 		3 ASN A 672
SER A 624
ARG A 597
 None
 0.83A 5b2qA-4zgcA:
undetectable		 5b2qA-4zgcA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqv CDII IMMUNITY
PROTEIN

(Yersinia
kristensenii) 		PF07262
(CdiI) 		3 ASN A 107
SER A  11
ARG A  32
 None
 0.94A 5b2qA-4zqvA:
undetectable		 5b2qA-4zqvA:
7.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b2o CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Francisella
tularensis) 		no annotation 3 ASN A1248
SER A1368
ARG A1370
 NA  A1703 ( 3.4A)
None
U  B  24 (-3.8A)
 0.04A 5b2qA-5b2oA:
undetectable		 5b2qA-5b2oA:
99.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8p MOCVNH3 VARIANT

(Magnaporthe
oryzae) 		PF01476
(LysM)
PF08881
(CVNH) 		3 ASN A  45
SER A 107
ARG A  82
 None
 0.88A 5b2qA-5c8pA:
undetectable		 5b2qA-5c8pA:
8.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5coz UNCHARACTERIZED
PROTEIN

([Eubacterium]
rectale) 		no annotation 3 ASN A  91
SER A  93
ARG A 144
 None
 0.83A 5b2qA-5cozA:
undetectable		 5b2qA-5cozA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cux ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
cruzi) 		PF00719
(Pyrophosphatase) 		3 ASN A 247
SER A 199
ARG A 406
 None
 0.95A 5b2qA-5cuxA:
undetectable		 5b2qA-5cuxA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9q NIH45-46 SINGLE
CHAIN FV

(Homo sapiens) 		PF07686
(V-set) 		3 ASN D 270
SER D 222
ARG D 224
 None
 0.88A 5b2qA-5d9qD:
undetectable		 5b2qA-5d9qD:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewn STRUCTURAL PROTEIN

(Mamastrovirus 1) 		PF03115
(Astro_capsid_N) 		3 ASN A 290
SER A 366
ARG A 317
 None
 0.90A 5b2qA-5ewnA:
undetectable		 5b2qA-5ewnA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		3 ASN A 203
SER A 196
ARG A 198
 None
 0.93A 5b2qA-5fqdA:
undetectable		 5b2qA-5fqdA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 3 ASN A 485
SER A 483
ARG A 489
 None
 0.95A 5b2qA-5h7jA:
undetectable		 5b2qA-5h7jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imt INTERMEDILYSIN

(Streptococcus
intermedius) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		3 ASN A 297
SER A 299
ARG A 205
 CU  A 609 (-4.2A)
CU  A 609 (-3.2A)
None
 0.95A 5b2qA-5imtA:
undetectable		 5b2qA-5imtA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mog PHYTOENE
DEHYDROGENASE,
CHLOROPLASTIC/CHROMO
PLASTIC

(Oryza sativa) 		PF01593
(Amino_oxidase) 		3 ASN A 221
SER A 200
ARG A 425
 None
 0.97A 5b2qA-5mogA:
undetectable		 5b2qA-5mogA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-) 		no annotation 3 ASN A 823
SER A 829
ARG A 834
 None
 0.80A 5b2qA-5mz9A:
undetectable		 5b2qA-5mz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzs FERRIC ENTEROBACTIN
RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 3 ASN A 164
SER A  44
ARG A 227
 None
 0.82A 5b2qA-5mzsA:
undetectable		 5b2qA-5mzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2w SHORT CHAIN
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		3 ASN A 193
SER A 187
ARG A 206
 NAP  A 301 ( 3.8A)
None
None
 0.81A 5b2qA-5u2wA:
undetectable		 5b2qA-5u2wA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 ASN A  42
SER A  45
ARG A 141
 None
 0.91A 5b2qA-5u7qA:
undetectable		 5b2qA-5u7qA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue7 PHOSPHOMANNOMUTASE

(Candida
albicans) 		PF03332
(PMM) 		3 ASN A 132
SER A 183
ARG A 145
 None
 0.78A 5b2qA-5ue7A:
undetectable		 5b2qA-5ue7A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f DNA REPLICATION
LICENSING FACTOR
MCM7

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		3 ASN 7 210
SER 7 395
ARG 7 400
 None
 0.83A 5b2qA-5v8f7:
undetectable		 5b2qA-5v8f7:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdu BNAB NIH45-46 SCFV
LIGHT CHAIN

(Homo sapiens) 		no annotation 3 ASN E  70
SER E  22
ARG E  24
 None
 0.94A 5b2qA-5wduE:
undetectable		 5b2qA-5wduE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yim SDEA

(Legionella
pneumophila) 		no annotation 3 ASN A 818
SER A 749
ARG A 595
 None
 0.91A 5b2qA-5yimA:
undetectable		 5b2qA-5yimA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfs PHOSPHOMANNOMUTASE 1

(Homo sapiens) 		no annotation 3 ASN A 137
SER A 139
ARG A 150
 None
 0.92A 5b2qA-6cfsA:
undetectable		 5b2qA-6cfsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 ASN A 227
SER A 230
ARG A 215
 None
 0.86A 5b2qA-6emkA:
undetectable		 5b2qA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9g METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
MCPU

(Pseudomonas
putida) 		no annotation 3 ASN A 269
SER A 258
ARG A 290
 None
 0.84A 5b2qA-6f9gA:
undetectable		 5b2qA-6f9gA:
undetectable