SIMILAR PATTERNS OF AMINO ACIDS FOR 5B2P_B_ACTB120

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hru YRDC GENE PRODUCT

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC) 		4 ASN A 174
SER A 176
ARG A 117
PRO A  92
 None
 1.41A 5b2pA-1hruA:
0.0		 5b2pA-1hruA:
8.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b2o CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Francisella
tularensis) 		no annotation 4 ASN A1248
SER A1368
ARG A1370
PRO A1444
 NA  A1703 ( 3.4A)
None
U  B  24 (-3.8A)
U  B  45 ( 4.1A)
 0.06A 5b2pA-5b2oA:
36.5		 5b2pA-5b2oA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Brucella canis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ASN A 392
SER A 536
ARG A 366
PRO A 535
 None
 1.36A 5b2pA-5u2aA:
0.0		 5b2pA-5u2aA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0t PROTEIN MSP1

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		4 ASN A 119
SER A 118
ARG A 228
PRO A 114
 None
 1.23A 5b2pA-5w0tA:
0.0		 5b2pA-5w0tA:
11.26