SIMILAR PATTERNS OF AMINO ACIDS FOR 5B1B_C_CHDC306_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB

(Thermus
thermophilus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		4 GLN A 383
PHE A  31
PHE A 386
LEU A 332
 None
 1.16A 5b1bC-1c4oA:
undetectable
5b1bJ-1c4oA:
0.0		 5b1bC-1c4oA:
16.59
5b1bJ-1c4oA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		4 GLN A 460
PHE A 367
LEU A 365
PHE A 422
 None
 1.05A 5b1bC-1cu1A:
0.2
5b1bJ-1cu1A:
0.0		 5b1bC-1cu1A:
18.31
5b1bJ-1cu1A:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dy2 COLLAGEN ALPHA1(XV)
CHAIN

(Mus musculus) 		PF06482
(Endostatin) 		4 GLN A 165
PHE A 166
PHE A 152
PHE A 159
 None
 0.92A 5b1bC-1dy2A:
undetectable
5b1bJ-1dy2A:
0.0		 5b1bC-1dy2A:
22.82
5b1bJ-1dy2A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		4 GLN A1336
PHE A1299
LEU A1305
PHE A1327
 None
 1.13A 5b1bC-1fdjA:
undetectable
5b1bJ-1fdjA:
0.0		 5b1bC-1fdjA:
18.85
5b1bJ-1fdjA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fkm PROTEIN (GYP1P)

(Saccharomyces
cerevisiae) 		PF00566
(RabGAP-TBC) 		4 GLN A 603
PHE A 479
LEU A 488
PHE A 492
 None
 1.14A 5b1bC-1fkmA:
0.0
5b1bJ-1fkmA:
0.0		 5b1bC-1fkmA:
20.41
5b1bJ-1fkmA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		4 GLN A 115
PHE A 121
LEU A 123
PHE A 106
 None
 1.06A 5b1bC-1gkrA:
0.0
5b1bJ-1gkrA:
0.0		 5b1bC-1gkrA:
18.57
5b1bJ-1gkrA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gm5 RECG

(Thermotoga
maritima) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF17190
(RecG_N)
PF17191
(RecG_wedge) 		4 PHE A 441
PHE A 361
LEU A 365
PHE A 367
 None
None
None
ADP  A1756 (-3.3A)
 1.06A 5b1bC-1gm5A:
2.9
5b1bJ-1gm5A:
0.2		 5b1bC-1gm5A:
15.64
5b1bJ-1gm5A:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE

(Escherichia
coli) 		PF00982
(Glyco_transf_20) 		4 PHE A 157
PHE A  88
LEU A  84
PHE A  79
 None
 1.04A 5b1bC-1gz5A:
undetectable
5b1bJ-1gz5A:
0.0		 5b1bC-1gz5A:
19.91
5b1bJ-1gz5A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		4 GLN C 783
PHE C 782
PHE C 751
LEU C 747
 None
 1.18A 5b1bC-1h2tC:
4.3
5b1bJ-1h2tC:
0.0		 5b1bC-1h2tC:
14.50
5b1bJ-1h2tC:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Thermotoga
maritima) 		PF01380
(SIS) 		4 PHE A  93
PHE A  95
LEU A  54
PHE A 152
 None
 1.18A 5b1bC-1j5xA:
0.0
5b1bJ-1j5xA:
undetectable		 5b1bC-1j5xA:
21.80
5b1bJ-1j5xA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		4 GLN A   4
PHE A 284
PHE A 290
PHE A 222
 None
 1.06A 5b1bC-1oltA:
undetectable
5b1bJ-1oltA:
undetectable		 5b1bC-1oltA:
20.00
5b1bJ-1oltA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovl ORPHAN NUCLEAR
RECEPTOR NURR1 (MSE
496, 511)

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 GLN B 571
PHE B 574
PHE B 592
LEU B 596
 None
 0.81A 5b1bC-1ovlB:
undetectable
5b1bJ-1ovlB:
undetectable		 5b1bC-1ovlB:
19.94
5b1bJ-1ovlB:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyi HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF13242
(Hydrolase_like) 		4 GLN A  61
PHE A  60
LEU A 137
PHE A 136
 None
 1.05A 5b1bC-1qyiA:
undetectable
5b1bJ-1qyiA:
undetectable		 5b1bC-1qyiA:
21.23
5b1bJ-1qyiA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6u TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 GLN A 304
PHE A 187
LEU A 183
PHE A 179
 None
 1.14A 5b1bC-1r6uA:
undetectable
5b1bJ-1r6uA:
undetectable		 5b1bC-1r6uA:
17.83
5b1bJ-1r6uA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svr SEVERIN

(Dictyostelium
discoideum) 		PF00626
(Gelsolin) 		4 GLN A 200
PHE A 201
PHE A 245
LEU A 249
 None
 0.92A 5b1bC-1svrA:
undetectable
5b1bJ-1svrA:
undetectable		 5b1bC-1svrA:
17.37
5b1bJ-1svrA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tq5 PROTEIN YHHW

(Escherichia
coli) 		PF02678
(Pirin) 		4 PHE A  34
PHE A  24
LEU A  40
PHE A 226
 None
 1.18A 5b1bC-1tq5A:
undetectable
5b1bJ-1tq5A:
undetectable		 5b1bC-1tq5A:
20.88
5b1bJ-1tq5A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un2 THIOL-DISULFIDE
INTERCHANGE PROTEIN

(Escherichia
coli) 		PF01323
(DSBA) 		4 GLN A 164
PHE A  13
LEU A 182
PHE A 118
 None
 1.16A 5b1bC-1un2A:
undetectable
5b1bJ-1un2A:
undetectable		 5b1bC-1un2A:
19.44
5b1bJ-1un2A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vax URIC ACID OXIDASE

(Arthrobacter
globiformis) 		PF01014
(Uricase) 		4 GLN A  47
PHE A  96
LEU A  92
PHE A  88
 None
 1.16A 5b1bC-1vaxA:
undetectable
5b1bJ-1vaxA:
undetectable		 5b1bC-1vaxA:
20.98
5b1bJ-1vaxA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfn PURINE-NUCLEOSIDE
PHOSPHORYLASE

(Bos taurus) 		PF01048
(PNP_UDP_1) 		4 PHE A  98
PHE A  56
LEU A  68
PHE A  70
 None
 1.15A 5b1bC-1vfnA:
undetectable
5b1bJ-1vfnA:
undetectable		 5b1bC-1vfnA:
24.03
5b1bJ-1vfnA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii) 		PF00285
(Citrate_synt) 		4 ARG A 248
GLN A 247
LEU A 300
PHE A 252
 None
 1.17A 5b1bC-1vgpA:
2.4
5b1bJ-1vgpA:
undetectable		 5b1bC-1vgpA:
19.90
5b1bJ-1vgpA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w93 ACETYL-COENZYME A
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ARG A 533
PHE A 490
LEU A 478
PHE A 480
 None
 1.15A 5b1bC-1w93A:
undetectable
5b1bJ-1w93A:
undetectable		 5b1bC-1w93A:
18.93
5b1bJ-1w93A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xho CHORISMATE MUTASE

(Ruminiclostridium
thermocellum) 		PF07736
(CM_1) 		4 ARG A  62
GLN A  24
PHE A  46
LEU A  71
 None
 0.91A 5b1bC-1xhoA:
undetectable
5b1bJ-1xhoA:
undetectable		 5b1bC-1xhoA:
17.72
5b1bJ-1xhoA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywq NITROREDUCTASE
FAMILY PROTEIN

(Bacillus cereus) 		PF00881
(Nitroreductase) 		4 GLN A 150
PHE A  64
LEU A  99
PHE A 101
 None
 0.94A 5b1bC-1ywqA:
undetectable
5b1bJ-1ywqA:
undetectable		 5b1bC-1ywqA:
21.40
5b1bJ-1ywqA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		4 PHE A 372
PHE A 301
LEU A 432
PHE A 395
 None
 1.18A 5b1bC-1yy5A:
undetectable
5b1bJ-1yy5A:
undetectable		 5b1bC-1yy5A:
19.02
5b1bJ-1yy5A:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zb7 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 GLN A 297
PHE A 296
PHE A 329
LEU A 303
 None
 1.14A 5b1bC-1zb7A:
undetectable
5b1bJ-1zb7A:
undetectable		 5b1bC-1zb7A:
18.67
5b1bJ-1zb7A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aug GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 14

(Homo sapiens) 		PF00017
(SH2) 		4 GLN A 489
PHE A 488
LEU A 516
PHE A 510
 None
 1.10A 5b1bC-2augA:
undetectable
5b1bJ-2augA:
undetectable		 5b1bC-2augA:
18.68
5b1bJ-2augA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3j RNA AND EXPORT
FACTOR BINDING
PROTEIN 2

(Mus musculus) 		PF00076
(RRM_1)
PF07078
(FYTT) 		4 GLN A 134
PHE A  98
PHE A  95
LEU A  77
 None
 1.11A 5b1bC-2f3jA:
undetectable
5b1bJ-2f3jA:
undetectable		 5b1bC-2f3jA:
21.85
5b1bJ-2f3jA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ifa HYPOTHETICAL PROTEIN
SMU.260

(Streptococcus
mutans) 		PF00881
(Nitroreductase) 		4 GLN A 148
PHE A  61
LEU A  97
PHE A  99
 FMN  A 501 (-3.8A)
None
None
None
 1.00A 5b1bC-2ifaA:
undetectable
5b1bJ-2ifaA:
undetectable		 5b1bC-2ifaA:
18.96
5b1bJ-2ifaA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jnu REGULATOR OF
G-PROTEIN SIGNALING
14

(Homo sapiens) 		PF00615
(RGS) 		4 ARG A  85
GLN A 108
PHE A  43
LEU A  73
 None
 1.08A 5b1bC-2jnuA:
3.1
5b1bJ-2jnuA:
undetectable		 5b1bC-2jnuA:
22.63
5b1bJ-2jnuA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1a HYPOTHETICAL PROTEIN

(Bacillus cereus) 		no annotation 4 GLN A   4
PHE A   2
PHE A 119
LEU A 123
 None
 1.12A 5b1bC-2p1aA:
2.7
5b1bJ-2p1aA:
undetectable		 5b1bC-2p1aA:
20.55
5b1bJ-2p1aA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n SKP1-LIKE PROTEIN 1A
TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF01466
(Skp1)
PF03931
(Skp1_POZ)
PF12937
(F-box-like) 		4 PHE A  99
PHE B   9
LEU B  14
PHE B  18
 None
 1.00A 5b1bC-2p1nA:
undetectable
5b1bJ-2p1nA:
undetectable		 5b1bC-2p1nA:
18.58
5b1bJ-2p1nA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4g TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		PF12009
(Telomerase_RBD) 		4 GLN A 382
PHE A 379
LEU A 405
PHE A 401
 None
 1.13A 5b1bC-2r4gA:
undetectable
5b1bJ-2r4gA:
undetectable		 5b1bC-2r4gA:
19.66
5b1bJ-2r4gA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2toh TYROSINE
3-MONOOXYGENASE

(Rattus
norvegicus) 		PF00351
(Biopterin_H) 		5 GLN A 347
PHE A 348
PHE A 345
LEU A 340
PHE A 309
 None
None
None
None
MTY  A 300 ( 3.9A)
 1.41A 5b1bC-2tohA:
undetectable
5b1bJ-2tohA:
undetectable		 5b1bC-2tohA:
21.19
5b1bJ-2tohA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w0i TWINFILIN-2

(Homo sapiens) 		PF00241
(Cofilin_ADF) 		4 PHE A 255
PHE A 238
LEU A 190
PHE A 287
 None
 1.06A 5b1bC-2w0iA:
undetectable
5b1bJ-2w0iA:
undetectable		 5b1bC-2w0iA:
19.83
5b1bJ-2w0iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF13519
(VWA_2) 		4 GLN A 578
PHE A 535
PHE A 383
LEU A 258
 None
 1.15A 5b1bC-2ww8A:
undetectable
5b1bJ-2ww8A:
undetectable		 5b1bC-2ww8A:
13.83
5b1bJ-2ww8A:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 ARG A 557
PHE A 523
LEU A 510
PHE A 480
 None
 1.16A 5b1bC-2xswA:
undetectable
5b1bJ-2xswA:
undetectable		 5b1bC-2xswA:
21.62
5b1bJ-2xswA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 GLN A 344
PHE A 342
LEU A 385
PHE A 387
 None
 0.96A 5b1bC-2z63A:
undetectable
5b1bJ-2z63A:
undetectable		 5b1bC-2z63A:
18.51
5b1bJ-2z63A:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3i PENICILLIN-BINDING
PROTEIN 4

(Haemophilus
influenzae) 		PF02113
(Peptidase_S13) 		4 GLN A 235
PHE A 251
LEU A 249
PHE A 247
 None
 1.17A 5b1bC-3a3iA:
undetectable
5b1bJ-3a3iA:
undetectable		 5b1bC-3a3iA:
20.00
5b1bJ-3a3iA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a64 CELLOBIOHYDROLASE

(Coprinopsis
cinerea) 		PF01341
(Glyco_hydro_6) 		4 GLN A 270
PHE A 278
LEU A 231
PHE A 212
 None
 1.17A 5b1bC-3a64A:
undetectable
5b1bJ-3a64A:
undetectable		 5b1bC-3a64A:
18.84
5b1bJ-3a64A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ail 303AA LONG
HYPOTHETICAL
ESTERASE

(Sulfurisphaera
tokodaii) 		PF07859
(Abhydrolase_3) 		4 ARG A 200
GLN A 208
PHE A 182
LEU A 184
 None
None
MRD  A 305 (-4.4A)
None
 1.02A 5b1bC-3ailA:
undetectable
5b1bJ-3ailA:
undetectable		 5b1bC-3ailA:
20.54
5b1bJ-3ailA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4

(Homo sapiens) 		PF00168
(C2) 		4 PHE A 109
PHE A 178
LEU A 187
PHE A 189
 None
 1.17A 5b1bC-3b7yA:
undetectable
5b1bJ-3b7yA:
undetectable		 5b1bC-3b7yA:
21.35
5b1bJ-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgh PUTATIVE
NEURAMINYLLACTOSE-BI
NDING HEMAGGLUTININ
HOMOLOG

(Helicobacter
pylori) 		PF05211
(NLBH) 		4 GLN A  78
PHE A  81
PHE A  44
LEU A  42
 None
 0.98A 5b1bC-3bghA:
1.9
5b1bJ-3bghA:
undetectable		 5b1bC-3bghA:
19.22
5b1bJ-3bghA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c75 METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN

(Paracoccus
versutus) 		PF06433
(Me-amine-dh_H) 		4 ARG H 172
GLN H 195
PHE H 196
PHE H 119
 None
 0.85A 5b1bC-3c75H:
undetectable
5b1bJ-3c75H:
undetectable		 5b1bC-3c75H:
19.95
5b1bJ-3c75H:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3m EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2

(Homo sapiens) 		PF02020
(W2) 		4 GLN A 817
PHE A 776
LEU A 772
PHE A 768
 None
 1.10A 5b1bC-3d3mA:
undetectable
5b1bJ-3d3mA:
undetectable		 5b1bC-3d3mA:
21.29
5b1bJ-3d3mA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fut DIMETHYLADENOSINE
TRANSFERASE

(Thermus
thermophilus) 		PF00398
(RrnaAD) 		4 GLN A 144
PHE A 184
LEU A 179
PHE A 177
 None
 1.06A 5b1bC-3futA:
undetectable
5b1bJ-3futA:
undetectable		 5b1bC-3futA:
22.11
5b1bJ-3futA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1z PUTATIVE LYSYL-TRNA
SYNTHETASE

(Salmonella
enterica) 		PF00152
(tRNA-synt_2) 		4 ARG A 188
GLN A 193
PHE A 196
PHE A 153
 None
 0.89A 5b1bC-3g1zA:
undetectable
5b1bJ-3g1zA:
undetectable		 5b1bC-3g1zA:
20.94
5b1bJ-3g1zA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs3 SYMPLEKIN

(Drosophila
melanogaster) 		PF11935
(DUF3453) 		4 GLN A 232
PHE A 233
LEU A 251
PHE A 269
 None
 1.12A 5b1bC-3gs3A:
undetectable
5b1bJ-3gs3A:
undetectable		 5b1bC-3gs3A:
19.29
5b1bJ-3gs3A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpc SNX5 PROTEIN

(Rattus
norvegicus) 		PF00787
(PX) 		4 GLN X 148
PHE X 162
LEU X 166
PHE X  63
 None
 1.12A 5b1bC-3hpcX:
undetectable
5b1bJ-3hpcX:
undetectable		 5b1bC-3hpcX:
20.23
5b1bJ-3hpcX:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		5 GLN A 698
PHE A 704
PHE A 708
LEU A 759
PHE A 754
 UNX  A 910 ( 4.6A)
None
UNX  A 901 ( 4.7A)
None
None
 1.47A 5b1bC-3hzjA:
undetectable
5b1bJ-3hzjA:
undetectable		 5b1bC-3hzjA:
23.38
5b1bJ-3hzjA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11

(Schizosaccharomyces
pombe) 		PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 ARG X1280
GLN X1121
PHE X1120
LEU X1126
 None
 1.13A 5b1bC-3jb9X:
undetectable
5b1bJ-3jb9X:
undetectable		 5b1bC-3jb9X:
11.15
5b1bJ-3jb9X:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4x PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 ARG A 491
GLN A 505
PHE A 504
LEU A 406
 None
 1.06A 5b1bC-3k4xA:
undetectable
5b1bJ-3k4xA:
undetectable		 5b1bC-3k4xA:
14.85
5b1bJ-3k4xA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus) 		PF01048
(PNP_UDP_1) 		4 PHE A  95
PHE A  53
LEU A  65
PHE A  67
 None
 1.17A 5b1bC-3khsA:
undetectable
5b1bJ-3khsA:
undetectable		 5b1bC-3khsA:
21.71
5b1bJ-3khsA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		4 GLN A 280
PHE A 239
LEU A 235
PHE A 231
 None
 1.16A 5b1bC-3l6aA:
undetectable
5b1bJ-3l6aA:
undetectable		 5b1bC-3l6aA:
20.70
5b1bJ-3l6aA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llb UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF03471
(CorC_HlyC) 		4 PHE A  61
PHE A  63
LEU A  41
PHE A  35
 None
 1.17A 5b1bC-3llbA:
undetectable
5b1bJ-3llbA:
undetectable		 5b1bC-3llbA:
15.22
5b1bJ-3llbA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 PHE A 327
PHE A 299
LEU A 296
PHE A 294
 None
 1.15A 5b1bC-3ogrA:
undetectable
5b1bJ-3ogrA:
undetectable		 5b1bC-3ogrA:
14.48
5b1bJ-3ogrA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oox PUTATIVE 2OG-FE(II)
OXYGENASE FAMILY
PROTEIN

(Caulobacter
vibrioides) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 PHE A  11
PHE A  21
LEU A  25
PHE A  29
 EDO  A 320 (-4.5A)
None
None
None
 1.13A 5b1bC-3ooxA:
undetectable
5b1bJ-3ooxA:
undetectable		 5b1bC-3ooxA:
19.64
5b1bJ-3ooxA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3q ALKALINE PHOSPHATASE

(Sphingomonas
sp. BSAR-1) 		PF01663
(Phosphodiest) 		4 ARG A 252
GLN A 266
PHE A 214
LEU A 218
 None
 1.16A 5b1bC-3q3qA:
undetectable
5b1bJ-3q3qA:
undetectable		 5b1bC-3q3qA:
18.10
5b1bJ-3q3qA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tjy EFFECTOR PROTEIN
HOPAB3

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 4 GLN A 188
PHE A 186
PHE A 190
LEU A 204
 None
 1.18A 5b1bC-3tjyA:
undetectable
5b1bJ-3tjyA:
undetectable		 5b1bC-3tjyA:
17.70
5b1bJ-3tjyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr8 OLIGORIBONUCLEASE

(Coxiella
burnetii) 		PF00929
(RNase_T) 		4 ARG A 113
GLN A 111
LEU A 104
PHE A 127
 None
 1.17A 5b1bC-3tr8A:
undetectable
5b1bJ-3tr8A:
undetectable		 5b1bC-3tr8A:
20.07
5b1bJ-3tr8A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wi3 DNA REPLICATION
REGULATOR SLD3

(Saccharomyces
cerevisiae) 		PF08639
(SLD3) 		4 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 1.07A 5b1bC-3wi3A:
1.7
5b1bJ-3wi3A:
undetectable		 5b1bC-3wi3A:
18.93
5b1bJ-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF04054
(Not1) 		4 GLN A2252
PHE A2251
LEU A2196
PHE A2192
 None
 1.00A 5b1bC-4c0dA:
2.5
5b1bJ-4c0dA:
undetectable		 5b1bC-4c0dA:
14.62
5b1bJ-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyl EFF-1A

(Caenorhabditis
elegans) 		PF14884
(EFF-AFF) 		4 GLN A  43
PHE A  44
PHE A 381
LEU A 379
 None
 0.99A 5b1bC-4cylA:
undetectable
5b1bJ-4cylA:
undetectable		 5b1bC-4cylA:
18.62
5b1bJ-4cylA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo sapiens) 		PF00621
(RhoGEF) 		4 GLN A2008
PHE A2011
PHE A2057
LEU A2061
 None
 0.82A 5b1bC-4d0oA:
3.6
5b1bJ-4d0oA:
undetectable		 5b1bC-4d0oA:
17.79
5b1bJ-4d0oA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Aneurinibacillus
thermoaerophilus) 		PF00483
(NTP_transferase) 		4 GLN A 121
PHE A 175
LEU A 173
PHE A 111
 None
 1.15A 5b1bC-4ho4A:
undetectable
5b1bJ-4ho4A:
undetectable		 5b1bC-4ho4A:
22.36
5b1bJ-4ho4A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqf THROMBOSPONDIN-RELAT
ED ANONYMOUS
PROTEIN, TRAP

(Plasmodium
falciparum) 		PF00092
(VWA) 		4 ARG A 176
GLN A 169
PHE A 198
LEU A 202
 None
 1.00A 5b1bC-4hqfA:
undetectable
5b1bJ-4hqfA:
undetectable		 5b1bC-4hqfA:
20.74
5b1bJ-4hqfA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1a RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE I

(Bacillus
subtilis) 		PF13424
(TPR_12) 		4 GLN A 276
PHE A 312
LEU A 308
PHE A 267
 None
 1.15A 5b1bC-4i1aA:
2.9
5b1bJ-4i1aA:
undetectable		 5b1bC-4i1aA:
22.11
5b1bJ-4i1aA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imi SYMPLEKIN

(Drosophila
melanogaster) 		PF11935
(DUF3453) 		4 GLN A 232
PHE A 233
LEU A 251
PHE A 269
 None
 1.15A 5b1bC-4imiA:
undetectable
5b1bJ-4imiA:
undetectable		 5b1bC-4imiA:
19.53
5b1bJ-4imiA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j72 PHOSPHO-N-ACETYLMURA
MOYL-PENTAPEPTIDE-TR
ANSFERASE

(Aquifex
aeolicus) 		PF00953
(Glycos_transf_4)
PF10555
(MraY_sig1) 		4 PHE A 180
PHE A 177
LEU A 158
PHE A 160
 None
 1.04A 5b1bC-4j72A:
undetectable
5b1bJ-4j72A:
undetectable		 5b1bC-4j72A:
22.37
5b1bJ-4j72A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 ARG A 484
GLN A 133
PHE A 134
LEU A 479
 None
 0.93A 5b1bC-4jsoA:
undetectable
5b1bJ-4jsoA:
undetectable		 5b1bC-4jsoA:
18.63
5b1bJ-4jsoA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmo PUTATIVE VACUOLAR
PROTEIN
SORTING-ASSOCIATED
PROTEIN

(Chaetomium
thermophilum) 		PF04840
(Vps16_C) 		4 GLN B 756
PHE B 753
PHE B 769
LEU B 765
 None
 0.94A 5b1bC-4kmoB:
undetectable
5b1bJ-4kmoB:
undetectable		 5b1bC-4kmoB:
19.53
5b1bJ-4kmoB:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l60 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 ARG A 224
GLN A 238
PHE A 237
LEU A 139
 None
 1.07A 5b1bC-4l60A:
undetectable
5b1bJ-4l60A:
undetectable		 5b1bC-4l60A:
21.54
5b1bJ-4l60A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llf CAPSID PROTEIN

(Cucumber
necrosis virus) 		PF00729
(Viral_coat) 		4 GLN A 230
PHE A 154
LEU A 152
PHE A 149
 None
 1.03A 5b1bC-4llfA:
undetectable
5b1bJ-4llfA:
undetectable		 5b1bC-4llfA:
21.36
5b1bJ-4llfA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8n PLEXINC1
INTRACELLULAR REGION

(Danio rerio) 		PF08337
(Plexin_cytopl) 		4 GLN A1114
PHE A 653
LEU A 657
PHE A 663
 None
 0.83A 5b1bC-4m8nA:
undetectable
5b1bJ-4m8nA:
undetectable		 5b1bC-4m8nA:
16.89
5b1bJ-4m8nA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5c CARGO-TRANSPORT
PROTEIN YPP1

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A 245
PHE A 269
LEU A 273
PHE A 277
 None
 1.07A 5b1bC-4n5cA:
3.6
5b1bJ-4n5cA:
undetectable		 5b1bC-4n5cA:
14.04
5b1bJ-4n5cA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		4 GLN A 375
PHE A 372
LEU A 299
PHE A 301
 None
 1.01A 5b1bC-4oyaA:
undetectable
5b1bJ-4oyaA:
undetectable		 5b1bC-4oyaA:
19.62
5b1bJ-4oyaA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qqb UPSTREAM OF N-RAS,
ISOFORM A

(Drosophila
melanogaster) 		PF00313
(CSD) 		4 ARG X  59
GLN X  36
PHE X  32
PHE X  31
 C  P  14 ( 3.0A)
None
None
A  P  15 ( 3.4A)
 1.00A 5b1bC-4qqbX:
undetectable
5b1bJ-4qqbX:
undetectable		 5b1bC-4qqbX:
14.58
5b1bJ-4qqbX:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1p L-ARABINOSE
ISOMERASE

(Geobacillus
kaustophilus) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		4 GLN A 295
PHE A 304
PHE A 276
LEU A 264
 None
 1.17A 5b1bC-4r1pA:
undetectable
5b1bJ-4r1pA:
undetectable		 5b1bC-4r1pA:
19.32
5b1bJ-4r1pA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN

(Nitratireductor
pacificus) 		PF12838
(Fer4_7)
PF13486
(Dehalogenase) 		4 ARG A 428
GLN A 403
PHE A  89
LEU A  90
 None
B12  A 803 (-3.7A)
None
None
 1.18A 5b1bC-4rasA:
undetectable
5b1bJ-4rasA:
undetectable		 5b1bC-4rasA:
15.49
5b1bJ-4rasA:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh0 SPORE PHOTOPRODUCT
LYASE

(Geobacillus
thermodenitrificans) 		no annotation 4 GLN A 251
PHE A 250
PHE A 332
LEU A 257
 None
 1.09A 5b1bC-4rh0A:
undetectable
5b1bJ-4rh0A:
undetectable		 5b1bC-4rh0A:
22.46
5b1bJ-4rh0A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsl FRUCTOSYL PEPTIDE
OXIDASE

(Penicillium
terrenum) 		PF01266
(DAO) 		4 GLN A 245
PHE A 336
LEU A 333
PHE A 268
 None
 1.13A 5b1bC-4rslA:
undetectable
5b1bJ-4rslA:
undetectable		 5b1bC-4rslA:
18.68
5b1bJ-4rslA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpx CELL DIVISION
CONTROL PROTEIN
31-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		4 ARG A  27
PHE A  50
PHE A  35
LEU A  34
 None
 1.02A 5b1bC-4wpxA:
undetectable
5b1bJ-4wpxA:
undetectable		 5b1bC-4wpxA:
21.84
5b1bJ-4wpxA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zel DOPAMINE
BETA-HYDROXYLASE

(Homo sapiens) 		PF01082
(Cu2_monooxygen)
PF03351
(DOMON)
PF03712
(Cu2_monoox_C) 		4 GLN A  75
PHE A  74
PHE A  87
LEU A  53
 None
 1.10A 5b1bC-4zelA:
undetectable
5b1bJ-4zelA:
undetectable		 5b1bC-4zelA:
17.32
5b1bJ-4zelA:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zij THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA

(Escherichia
coli) 		PF01323
(DSBA) 		4 GLN A  74
PHE A 112
LEU A  92
PHE A  28
 None
 1.17A 5b1bC-4zijA:
undetectable
5b1bJ-4zijA:
undetectable		 5b1bC-4zijA:
19.69
5b1bJ-4zijA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zox RIBOSOME ASSEMBLY
PROTEIN SQT1

(Saccharomyces
cerevisiae) 		no annotation 4 GLN A 383
PHE A 349
LEU A 365
PHE A 360
 None
 1.14A 5b1bC-4zoxA:
undetectable
5b1bJ-4zoxA:
undetectable		 5b1bC-4zoxA:
22.88
5b1bJ-4zoxA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4s CHITOSANASE

(Mitsuaria
chitosanitabida) 		PF13647
(Glyco_hydro_80) 		4 PHE A  93
PHE A  85
LEU A 130
PHE A 123
 None
 1.06A 5b1bC-5b4sA:
undetectable
5b1bJ-5b4sA:
undetectable		 5b1bC-5b4sA:
22.65
5b1bJ-5b4sA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bza BETA-N-ACETYLHEXOSAM
INIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3) 		4 GLN A 460
PHE A 459
PHE A 378
LEU A 343
 None
 0.81A 5b1bC-5bzaA:
undetectable
5b1bJ-5bzaA:
undetectable		 5b1bC-5bzaA:
17.12
5b1bJ-5bzaA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9h TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		PF12009
(Telomerase_RBD) 		4 GLN A 382
PHE A 379
LEU A 405
PHE A 401
 None
 1.02A 5b1bC-5c9hA:
undetectable
5b1bJ-5c9hA:
undetectable		 5b1bC-5c9hA:
18.61
5b1bJ-5c9hA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejj UFM1-SPECIFIC
PROTEASE

(Caenorhabditis
elegans) 		PF07910
(Peptidase_C78) 		4 ARG A 277
GLN A  74
PHE A  49
LEU A  80
 None
 1.18A 5b1bC-5ejjA:
undetectable
5b1bJ-5ejjA:
undetectable		 5b1bC-5ejjA:
20.36
5b1bJ-5ejjA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g39 PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE

(Thermosynechococcus
elongatus) 		PF01716
(MSP) 		4 GLN A  97
PHE A 113
PHE A  50
LEU A  63
 None
 1.11A 5b1bC-5g39A:
undetectable
5b1bJ-5g39A:
undetectable		 5b1bC-5g39A:
23.68
5b1bJ-5g39A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huu ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
[UDP-FORMING]

(Candida
albicans) 		PF00982
(Glyco_transf_20) 		4 PHE A 174
PHE A 101
LEU A  97
PHE A  92
 None
 1.06A 5b1bC-5huuA:
undetectable
5b1bJ-5huuA:
undetectable		 5b1bC-5huuA:
19.58
5b1bJ-5huuA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvm ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Aspergillus
fumigatus) 		PF00982
(Glyco_transf_20) 		4 PHE A 182
PHE A 109
LEU A 105
PHE A 100
 None
 1.03A 5b1bC-5hvmA:
undetectable
5b1bJ-5hvmA:
undetectable		 5b1bC-5hvmA:
18.38
5b1bJ-5hvmA:
8.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iy5 CYTOCHROME C OXIDASE
SUBUNIT 3

(Bos taurus) 		PF00510
(COX3) 		5 ARG C 156
GLN C 161
PHE C 164
PHE C 219
LEU C 223
 CHD  C 307 (-4.0A)
CHD  C 307 (-4.3A)
CHD  C 307 (-3.9A)
None
None
 0.14A 5b1bC-5iy5C:
37.4
5b1bJ-5iy5C:
undetectable		 5b1bC-5iy5C:
100.00
5b1bJ-5iy5C:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oen INTERFERON
REGULATORY FACTOR 9

(Mus musculus) 		no annotation 4 PHE A 339
PHE A 322
LEU A 326
PHE A 330
 None
 1.04A 5b1bC-5oenA:
undetectable
5b1bJ-5oenA:
undetectable		 5b1bC-5oenA:
undetectable
5b1bJ-5oenA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0t ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		4 PHE A 167
PHE A  98
LEU A  94
PHE A  89
 None
 0.95A 5b1bC-5v0tA:
undetectable
5b1bJ-5v0tA:
undetectable		 5b1bC-5v0tA:
20.08
5b1bJ-5v0tA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vai UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF00002
(7tm_2)
PF02793
(HRM) 		4 GLN R 410
PHE R 413
PHE R 169
LEU R 172
 None
 1.12A 5b1bC-5vaiR:
2.0
5b1bJ-5vaiR:
undetectable		 5b1bC-5vaiR:
19.18
5b1bJ-5vaiR:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C)
PF01801
(Cytomega_gL) 		4 PHE A  90
PHE A  80
LEU B 183
PHE B 222
 None
 1.13A 5b1bC-5vocA:
2.5
5b1bJ-5vocA:
undetectable		 5b1bC-5vocA:
15.48
5b1bJ-5vocA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zut PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		no annotation 4 ARG A 224
GLN A 238
PHE A 237
LEU A 139
 None
 1.13A 5b1bC-5zutA:
undetectable
5b1bJ-5zutA:
undetectable		 5b1bC-5zutA:
undetectable
5b1bJ-5zutA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cwo RIBONUCLEOTIDE
REDUCTASE

(Flavobacterium
johnsoniae) 		no annotation 4 GLN A 167
PHE A 165
PHE A 291
LEU A 172
 None
 1.12A 5b1bC-6cwoA:
2.9
5b1bJ-6cwoA:
undetectable		 5b1bC-6cwoA:
undetectable
5b1bJ-6cwoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cwp RIBONUCLEOTIDE
REDUCTASE

(Flavobacterium
johnsoniae) 		no annotation 4 GLN A 167
PHE A 165
PHE A 291
LEU A 172
 None
 1.12A 5b1bC-6cwpA:
3.1
5b1bJ-6cwpA:
undetectable		 5b1bC-6cwpA:
undetectable
5b1bJ-6cwpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhm -

(-) 		no annotation 4 GLN A 139
PHE A 140
PHE A 127
LEU A 115
 None
 1.11A 5b1bC-6fhmA:
undetectable
5b1bJ-6fhmA:
undetectable		 5b1bC-6fhmA:
undetectable
5b1bJ-6fhmA:
undetectable