SIMILAR PATTERNS OF AMINO ACIDS FOR 5B1A_W_CHDW101

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5l INTERFERON TAU

(Komagataella
pastoris) 		PF00143
(Interferon) 		4 ILE A 127
LEU A  67
PHE A 124
THR A 153
 None
 1.06A 5b1aN-1b5lA:
3.3
5b1aW-1b5lA:
0.0		 5b1aN-1b5lA:
15.18
5b1aW-1b5lA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI

(Pantoea
stewartii) 		PF00765
(Autoind_synth) 		4 ILE A 141
PHE A  86
ARG A 170
THR A 166
 REO  A 407 (-4.6A)
None
None
None
 1.03A 5b1aN-1k4jA:
0.1
5b1aW-1k4jA:
0.0		 5b1aN-1k4jA:
18.26
5b1aW-1k4jA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE

(Methylobacterium
extorquens) 		PF09176
(Mpt_N) 		4 ILE A 264
LEU A 267
PHE A 268
THR A  32
 None
 1.05A 5b1aN-1luaA:
0.0
5b1aW-1luaA:
0.0		 5b1aN-1luaA:
19.12
5b1aW-1luaA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc8 FLAP ENDONUCLEASE-1

(Pyrococcus
horikoshii) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 ILE A   5
LEU A   8
ARG A 223
THR A 222
 None
 1.01A 5b1aN-1mc8A:
0.0
5b1aW-1mc8A:
0.0		 5b1aN-1mc8A:
20.59
5b1aW-1mc8A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		4 ILE D 318
LEU D 321
ARG D 330
THR D 269
 None
 0.99A 5b1aN-1mhzD:
0.3
5b1aW-1mhzD:
0.0		 5b1aN-1mhzD:
21.42
5b1aW-1mhzD:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ni6 HEME OXYGENASE 1

(Homo sapiens) 		PF01126
(Heme_oxygenase) 		4 ILE A  65
LEU A 129
PHE A  74
TYR A 182
 None
 1.06A 5b1aN-1ni6A:
1.9
5b1aW-1ni6A:
0.0		 5b1aN-1ni6A:
17.99
5b1aW-1ni6A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot5 KEXIN

(Saccharomyces
cerevisiae) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 ILE A 570
PHE A 583
ARG A 587
THR A 553
 None
 1.04A 5b1aN-1ot5A:
0.0
5b1aW-1ot5A:
0.0		 5b1aN-1ot5A:
21.15
5b1aW-1ot5A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pm2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
BETA CHAIN

(Escherichia
coli) 		PF00268
(Ribonuc_red_sm) 		5 ILE A 335
LEU A 339
TYR A 310
ARG A 328
THR A 312
 None
None
None
HG  A 614 ( 4.9A)
None
 1.29A 5b1aN-1pm2A:
0.8
5b1aW-1pm2A:
0.0		 5b1aN-1pm2A:
19.19
5b1aW-1pm2A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E

(Streptococcus
pyogenes) 		PF01515
(PTA_PTB) 		4 PHE A  40
TYR A  69
ARG A  56
THR A  60
 None
 1.00A 5b1aN-1r5jA:
0.0
5b1aW-1r5jA:
0.0		 5b1aN-1r5jA:
22.69
5b1aW-1r5jA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc9 CYSTEINE-RICH
SECRETORY PROTEIN

(Trimeresurus
stejnegeri) 		PF00188
(CAP)
PF08562
(Crisp) 		4 ILE A  90
LEU A  21
TYR A 147
THR A 117
 None
 1.06A 5b1aN-1rc9A:
undetectable
5b1aW-1rc9A:
undetectable		 5b1aN-1rc9A:
17.70
5b1aW-1rc9A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR

(Bacillus
megaterium) 		no annotation 4 ILE G 121
LEU G 305
ARG G  80
THR G  87
 None
 1.06A 5b1aN-1rzrG:
0.0
5b1aW-1rzrG:
undetectable		 5b1aN-1rzrG:
20.77
5b1aW-1rzrG:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmx HYDROXYQUINOL
1,2-DIOXYGENASE

(Pimelobacter
simplex) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 ILE A 238
LEU A 222
PHE A 224
TYR A 187
 None
 0.97A 5b1aN-1tmxA:
2.0
5b1aW-1tmxA:
undetectable		 5b1aN-1tmxA:
20.53
5b1aW-1tmxA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Pyrococcus
furiosus) 		PF13476
(AAA_23) 		4 ILE A  84
LEU A  73
ARG A 102
THR A  80
 None
 0.90A 5b1aN-1us8A:
undetectable
5b1aW-1us8A:
undetectable		 5b1aN-1us8A:
14.25
5b1aW-1us8A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl7 HYPOTHETICAL PROTEIN
ALR5027

(Nostoc sp. PCC
7120) 		PF01243
(Putative_PNPOx) 		4 ILE A  15
LEU A  87
PHE A  71
THR A 133
 None
 0.91A 5b1aN-1vl7A:
undetectable
5b1aW-1vl7A:
undetectable		 5b1aN-1vl7A:
13.81
5b1aW-1vl7A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvr TRIFLIN

(Protobothrops
flavoviridis) 		PF00188
(CAP)
PF08562
(Crisp) 		4 ILE A  90
LEU A  21
TYR A 147
THR A 117
 None
 1.05A 5b1aN-1wvrA:
undetectable
5b1aW-1wvrA:
undetectable		 5b1aN-1wvrA:
15.85
5b1aW-1wvrA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xx5 NATRIN 1

(Naja atra) 		PF00188
(CAP)
PF08562
(Crisp) 		4 ILE A  90
LEU A  21
TYR A 147
THR A 117
 None
 1.07A 5b1aN-1xx5A:
undetectable
5b1aW-1xx5A:
undetectable		 5b1aN-1xx5A:
16.47
5b1aW-1xx5A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwj ADENYLATE KINASE 5

(Homo sapiens) 		PF00406
(ADK) 		4 ILE A  14
LEU A  94
PHE A  37
THR A 191
 None
 1.04A 5b1aN-2bwjA:
undetectable
5b1aW-2bwjA:
undetectable		 5b1aN-2bwjA:
17.49
5b1aW-2bwjA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cph RNA BINDING MOTIF
PROTEIN 19

(Mus musculus) 		PF00076
(RRM_1) 		4 ILE A 478
LEU A 481
PHE A 482
ARG A 467
 None
 0.90A 5b1aN-2cphA:
undetectable
5b1aW-2cphA:
undetectable		 5b1aN-2cphA:
12.76
5b1aW-2cphA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb1 ENDORIBONUCLEASE
DICER

(Homo sapiens) 		PF00636
(Ribonuclease_3) 		4 ILE A  86
LEU A  90
PHE A  87
ARG A  78
 None
 1.02A 5b1aN-2eb1A:
undetectable
5b1aW-2eb1A:
undetectable		 5b1aN-2eb1A:
16.17
5b1aW-2eb1A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efj 3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		4 ILE A 373
LEU A 223
PHE A 225
THR A 201
 None
 0.93A 5b1aN-2efjA:
undetectable
5b1aW-2efjA:
undetectable		 5b1aN-2efjA:
22.83
5b1aW-2efjA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o39 FIBER PROTEIN

(Human
mastadenovirus
B) 		PF00541
(Adeno_knob) 		4 ILE A 290
LEU A 197
PHE A 199
ARG A 322
 None
 1.02A 5b1aN-2o39A:
undetectable
5b1aW-2o39A:
undetectable		 5b1aN-2o39A:
16.86
5b1aW-2o39A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4o HYPOTHETICAL PROTEIN

(Nostoc
punctiforme) 		no annotation 4 ILE A 213
LEU A 190
TYR A  11
THR A 244
 None
 1.05A 5b1aN-2p4oA:
undetectable
5b1aW-2p4oA:
undetectable		 5b1aN-2p4oA:
20.92
5b1aW-2p4oA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5r GLUTATHIONE
PEROXIDASE 5

(Populus
trichocarpa x
Populus
deltoides) 		PF00255
(GSHPx) 		4 ILE A  37
LEU A  69
PHE A  71
ARG A 117
 None
 0.99A 5b1aN-2p5rA:
undetectable
5b1aW-2p5rA:
undetectable		 5b1aN-2p5rA:
15.09
5b1aW-2p5rA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7s N-FORMYLGLUTAMATE
AMIDOHYDROLASE

(Cupriavidus
pinatubonensis) 		PF05013
(FGase) 		4 ILE A 250
PHE A 192
ARG A 272
THR A 275
 None
 0.93A 5b1aN-2q7sA:
undetectable
5b1aW-2q7sA:
undetectable		 5b1aN-2q7sA:
19.19
5b1aW-2q7sA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v3m NAF1

(Saccharomyces
cerevisiae) 		PF04410
(Gar1) 		4 ILE A 153
LEU A 143
ARG A 162
THR A 138
 None
 1.02A 5b1aN-2v3mA:
undetectable
5b1aW-2v3mA:
undetectable		 5b1aN-2v3mA:
12.45
5b1aW-2v3mA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5p CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR

(Homo sapiens) 		PF00040
(fn2)
PF00878
(CIMR) 		4 ILE A1552
LEU A1590
PHE A1612
ARG A1623
 None
 1.06A 5b1aN-2v5pA:
undetectable
5b1aW-2v5pA:
undetectable		 5b1aN-2v5pA:
20.65
5b1aW-2v5pA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6e PROTELEMORASE

(Klebsiella
phage phiKO2) 		PF16684
(Telomere_res) 		4 ILE A 279
LEU A 268
ARG A 310
THR A 294
 None
 1.04A 5b1aN-2v6eA:
undetectable
5b1aW-2v6eA:
undetectable		 5b1aN-2v6eA:
19.87
5b1aW-2v6eA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1z ROP2

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		4 ILE A 480
LEU A 517
PHE A 520
ARG A 395
 None
 1.01A 5b1aN-2w1zA:
undetectable
5b1aW-2w1zA:
undetectable		 5b1aN-2w1zA:
20.08
5b1aW-2w1zA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyh ALPHA-MANNOSIDASE

(Streptococcus
pyogenes) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 ILE A 614
LEU A 646
PHE A 612
THR A 753
 None
 1.00A 5b1aN-2wyhA:
2.2
5b1aW-2wyhA:
undetectable		 5b1aN-2wyhA:
20.26
5b1aW-2wyhA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Bacillus
subtilis) 		PF01008
(IF-2B) 		4 ILE A 343
LEU A 346
PHE A 347
ARG A 241
 None
 0.92A 5b1aN-2yrfA:
undetectable
5b1aW-2yrfA:
undetectable		 5b1aN-2yrfA:
20.95
5b1aW-2yrfA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1z HEMOLYMPH JUVENILE
HORMONE BINDING
PROTEIN

(Bombyx mori) 		PF06585
(JHBP) 		4 ILE A 196
LEU A  48
PHE A  62
ARG A 189
 None
 1.06A 5b1aN-3a1zA:
undetectable
5b1aW-3a1zA:
undetectable		 5b1aN-3a1zA:
17.58
5b1aW-3a1zA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anw PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermococcus
kodakarensis) 		no annotation 4 ILE A 141
LEU A 145
PHE A 159
THR A 169
 None
 0.98A 5b1aN-3anwA:
undetectable
5b1aW-3anwA:
undetectable		 5b1aN-3anwA:
16.15
5b1aW-3anwA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asm RIBONUCLEASE HIII

(Geobacillus
stearothermophilus) 		PF01351
(RNase_HII)
PF11858
(DUF3378) 		4 ILE A 201
PHE A 204
ARG A 182
THR A 155
 None
 1.02A 5b1aN-3asmA:
undetectable
5b1aW-3asmA:
undetectable		 5b1aN-3asmA:
19.81
5b1aW-3asmA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcp HISTIDINOL-PHOSPHATA
SE

(Listeria
monocytogenes) 		PF02811
(PHP)
PF13263
(PHP_C) 		4 LEU A  30
PHE A  32
TYR A 255
THR A 271
 None
 0.79A 5b1aN-3dcpA:
undetectable
5b1aW-3dcpA:
undetectable		 5b1aN-3dcpA:
19.37
5b1aW-3dcpA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwv GLUTATHIONE
PEROXIDASE-LIKE
PROTEIN

(Trypanosoma
brucei) 		PF00255
(GSHPx) 		4 ILE A  15
LEU A  30
PHE A  16
ARG A 146
 None
 1.06A 5b1aN-3dwvA:
undetectable
5b1aW-3dwvA:
undetectable		 5b1aN-3dwvA:
16.96
5b1aW-3dwvA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1

(Methanosarcina
barkeri) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		4 ILE A  40
LEU A  37
ARG A 111
THR A 114
 None
 0.91A 5b1aN-3ezxA:
undetectable
5b1aW-3ezxA:
undetectable		 5b1aN-3ezxA:
18.16
5b1aW-3ezxA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 ILE A 875
LEU A 993
PHE A 994
ARG A 825
 None
 1.02A 5b1aN-3f2bA:
undetectable
5b1aW-3f2bA:
undetectable		 5b1aN-3f2bA:
20.21
5b1aW-3f2bA:
4.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE

(Corynebacterium
diphtheriae) 		PF00155
(Aminotran_1_2) 		4 ILE A 302
LEU A 290
ARG A 351
THR A 308
 None
None
CL  A 379 ( 3.1A)
None
 0.95A 5b1aN-3fdbA:
undetectable
5b1aW-3fdbA:
undetectable		 5b1aN-3fdbA:
20.93
5b1aW-3fdbA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hr6 PUTATIVE
SURFACE-ANCHORED
FIMBRIAL SUBUNIT

(Corynebacterium
diphtheriae) 		no annotation 4 ILE A 417
LEU A 464
PHE A 442
THR A 421
 None
None
None
IOD  A 487 (-3.9A)
 1.01A 5b1aN-3hr6A:
undetectable
5b1aW-3hr6A:
undetectable		 5b1aN-3hr6A:
21.15
5b1aW-3hr6A:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2m ORF59

(Human
gammaherpesvirus
8) 		PF04929
(Herpes_DNAp_acc) 		4 LEU X  98
PHE X  99
ARG X  61
THR X  45
 None
 0.97A 5b1aN-3i2mX:
undetectable
5b1aW-3i2mX:
undetectable		 5b1aN-3i2mX:
20.62
5b1aW-3i2mX:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix1 N-FORMYL-4-AMINO-5-A
MINOMETHYL-2-METHYLP
YRIMIDINE BINDING
PROTEIN

(Bacillus
halodurans) 		PF09084
(NMT1) 		4 ILE A  66
LEU A  37
PHE A  68
THR A 262
 None
 0.89A 5b1aN-3ix1A:
undetectable
5b1aW-3ix1A:
undetectable		 5b1aN-3ix1A:
19.80
5b1aW-3ix1A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k25 SLR1438 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF01263
(Aldose_epim) 		4 ILE A 179
LEU A 240
PHE A 210
THR A 244
 None
 1.01A 5b1aN-3k25A:
undetectable
5b1aW-3k25A:
undetectable		 5b1aN-3k25A:
17.92
5b1aW-3k25A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrk ALPHA-GALACTOSIDASE
1

(Saccharomyces
cerevisiae) 		PF16499
(Melibiase_2) 		4 ILE A  69
LEU A 103
PHE A 108
ARG A  55
 None
 0.96A 5b1aN-3lrkA:
undetectable
5b1aW-3lrkA:
undetectable		 5b1aN-3lrkA:
20.99
5b1aW-3lrkA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olm E3 UBIQUITIN-PROTEIN
LIGASE RSP5

(Saccharomyces
cerevisiae) 		PF00397
(WW)
PF00632
(HECT) 		4 ILE A 464
PHE A 488
ARG A 560
THR A 740
 None
 0.94A 5b1aN-3olmA:
undetectable
5b1aW-3olmA:
undetectable		 5b1aN-3olmA:
20.60
5b1aW-3olmA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poa PUTATIVE
UNCHARACTERIZED
PROTEIN TB39.8

(Mycobacterium
tuberculosis) 		PF00498
(FHA) 		4 ILE A  85
LEU A  87
ARG A  95
THR A  17
 None
 1.01A 5b1aN-3poaA:
undetectable
5b1aW-3poaA:
undetectable		 5b1aN-3poaA:
10.83
5b1aW-3poaA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9o EXOTOXIN A

(Vibrio cholerae) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		4 ILE A 584
LEU A 492
ARG A 543
THR A 496
 None
NAD  A 700 ( 4.7A)
None
None
 1.07A 5b1aN-3q9oA:
undetectable
5b1aW-3q9oA:
undetectable		 5b1aN-3q9oA:
20.91
5b1aW-3q9oA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqi KLLA0E03807P

(Kluyveromyces
lactis) 		PF16787
(NDC10_II) 		4 ILE A 361
LEU A 367
PHE A 362
THR A 347
 None
 1.05A 5b1aN-3sqiA:
undetectable
5b1aW-3sqiA:
undetectable		 5b1aN-3sqiA:
19.72
5b1aW-3sqiA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t79 KLLA0E03807P

(Kluyveromyces
lactis) 		PF16787
(NDC10_II) 		4 ILE A 361
LEU A 367
PHE A 362
THR A 347
 None
 1.03A 5b1aN-3t79A:
undetectable
5b1aW-3t79A:
undetectable		 5b1aN-3t79A:
20.72
5b1aW-3t79A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 ILE A4255
PHE A4252
ARG A4269
THR A4387
 None
 1.00A 5b1aN-3vkgA:
undetectable
5b1aW-3vkgA:
undetectable		 5b1aN-3vkgA:
9.59
5b1aW-3vkgA:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wuy NITRILASE

(Synechocystis
sp. PCC 6803) 		PF00795
(CN_hydrolase) 		4 ILE A  93
LEU A 106
PHE A 123
THR A  84
 None
 1.06A 5b1aN-3wuyA:
undetectable
5b1aW-3wuyA:
undetectable		 5b1aN-3wuyA:
21.72
5b1aW-3wuyA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		4 ILE A 387
LEU A 381
ARG A 340
THR A 402
 None
 0.98A 5b1aN-3wzfA:
undetectable
5b1aW-3wzfA:
undetectable		 5b1aN-3wzfA:
20.90
5b1aW-3wzfA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx2 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 1

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		4 ILE A 438
LEU A 424
PHE A 430
THR A 221
 None
 1.01A 5b1aN-3zx2A:
undetectable
5b1aW-3zx2A:
undetectable		 5b1aN-3zx2A:
21.66
5b1aW-3zx2A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		4 ILE A 329
LEU A 379
PHE A 381
ARG A 393
 None
 1.07A 5b1aN-4bfrA:
undetectable
5b1aW-4bfrA:
undetectable		 5b1aN-4bfrA:
18.38
5b1aW-4bfrA:
4.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4biz SENSOR PROTEIN CPXA

(Escherichia
coli) 		PF00512
(HisKA)
PF00672
(HAMP)
PF02518
(HATPase_c) 		4 ILE A 399
LEU A 421
PHE A 400
THR A 383
 ADP  A 501 (-4.4A)
ADP  A 501 (-3.8A)
None
None
 0.88A 5b1aN-4bizA:
3.5
5b1aW-4bizA:
undetectable		 5b1aN-4bizA:
17.40
5b1aW-4bizA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eto PROTEIN S100-A4

(Homo sapiens) 		PF01023
(S_100) 		4 ILE A  82
LEU A  79
PHE A  78
THR A  39
 None
 1.03A 5b1aN-4etoA:
undetectable
5b1aW-4etoA:
undetectable		 5b1aN-4etoA:
9.45
5b1aW-4etoA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyv PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Serendipita
indica) 		PF00160
(Pro_isomerase) 		4 ILE A 114
LEU A  62
PHE A  53
ARG A  19
 None
 1.04A 5b1aN-4eyvA:
undetectable
5b1aW-4eyvA:
undetectable		 5b1aN-4eyvA:
17.98
5b1aW-4eyvA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgm AMINOPEPTIDASE N
FAMILY PROTEIN

(Idiomarina
loihiensis) 		PF05299
(Peptidase_M61)
PF13180
(PDZ_2) 		4 ILE A 183
PHE A 220
TYR A 275
THR A 210
 None
 0.96A 5b1aN-4fgmA:
undetectable
5b1aW-4fgmA:
undetectable		 5b1aN-4fgmA:
21.18
5b1aW-4fgmA:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fi9 SUN
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF07738
(Sad1_UNC) 		4 ILE A 648
LEU A 662
PHE A 679
ARG A 710
 None
 0.89A 5b1aN-4fi9A:
undetectable
5b1aW-4fi9A:
undetectable		 5b1aN-4fi9A:
17.12
5b1aW-4fi9A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ILE A3361
LEU A3395
PHE A3446
ARG A3345
 None
 0.91A 5b1aN-4kc5A:
undetectable
5b1aW-4kc5A:
undetectable		 5b1aN-4kc5A:
19.34
5b1aW-4kc5A:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdx GLUTATHIONE
S-TRANSFERASE DOMAIN

(Paraburkholderia
graminis) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 ILE A 169
LEU A 173
TYR A 198
ARG A 195
 None
 0.97A 5b1aN-4kdxA:
undetectable
5b1aW-4kdxA:
undetectable		 5b1aN-4kdxA:
17.55
5b1aW-4kdxA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lj2 CHORISMATE SYNTHASE

(Acinetobacter
baumannii) 		PF01264
(Chorismate_synt) 		4 ILE A 140
PHE A  10
ARG A 134
THR A  14
 None
 1.02A 5b1aN-4lj2A:
undetectable
5b1aW-4lj2A:
undetectable		 5b1aN-4lj2A:
21.71
5b1aW-4lj2A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1a HYPOTHETICAL PROTEIN

(Sebaldella
termitidis) 		PF08921
(DUF1904) 		4 ILE A  73
PHE A  77
ARG A   5
THR A  37
 None
 1.01A 5b1aN-4m1aA:
undetectable
5b1aW-4m1aA:
undetectable		 5b1aN-4m1aA:
12.03
5b1aW-4m1aA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA

(Klebsiella
pneumoniae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ILE H 534
LEU H 497
PHE H 501
ARG H 409
 None
 1.02A 5b1aN-4nl4H:
undetectable
5b1aW-4nl4H:
undetectable		 5b1aN-4nl4H:
20.03
5b1aW-4nl4H:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		4 ILE A 272
LEU A 326
PHE A 325
THR A 303
 None
 0.89A 5b1aN-4o5pA:
undetectable
5b1aW-4o5pA:
undetectable		 5b1aN-4o5pA:
19.53
5b1aW-4o5pA:
5.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbv NT-3 GROWTH FACTOR
RECEPTOR

(Gallus gallus) 		PF00047
(ig)
PF13855
(LRR_8)
PF16920
(TPKR_C2) 		4 LEU A 146
PHE A 147
ARG A 156
THR A 109
 None
 0.94A 5b1aN-4pbvA:
undetectable
5b1aW-4pbvA:
undetectable		 5b1aN-4pbvA:
18.97
5b1aW-4pbvA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD

(Escherichia
coli) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 ILE A 523
LEU A 520
ARG A 493
THR A 425
 None
 0.93A 5b1aN-4pl0A:
4.1
5b1aW-4pl0A:
undetectable		 5b1aN-4pl0A:
21.25
5b1aW-4pl0A:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qaw XYN30D

(Paenibacillus
barcinonensis) 		PF03422
(CBM_6)
PF17189
(Glyco_hydro_30C) 		4 ILE A 499
PHE A 459
ARG A 511
THR A 509
 None
 0.89A 5b1aN-4qawA:
undetectable
5b1aW-4qawA:
undetectable		 5b1aN-4qawA:
23.40
5b1aW-4qawA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qme AMINOPEPTIDASE N

(Neisseria
meningitidis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 ILE A 338
LEU A 610
PHE A 607
THR A 565
 None
None
None
SO4  A 917 (-4.1A)
 1.01A 5b1aN-4qmeA:
3.0
5b1aW-4qmeA:
undetectable		 5b1aN-4qmeA:
19.71
5b1aW-4qmeA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyb UNCHARACTERIZED
PROTEIN

(Burkholderia
cenocepacia) 		PF10765
(DUF2591) 		4 ILE A  56
LEU A  60
PHE A  62
ARG A 104
 None
 1.00A 5b1aN-4qybA:
undetectable
5b1aW-4qybA:
undetectable		 5b1aN-4qybA:
14.50
5b1aW-4qybA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1w ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		4 ILE A 110
LEU A 266
PHE A 267
THR A 286
 None
 0.92A 5b1aN-4w1wA:
undetectable
5b1aW-4w1wA:
undetectable		 5b1aN-4w1wA:
22.73
5b1aW-4w1wA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd4 HEME OXYGENASE 1

(Homo sapiens) 		PF01126
(Heme_oxygenase) 		4 ILE A  65
LEU A 129
PHE A  74
TYR A 182
 None
 0.99A 5b1aN-4wd4A:
1.9
5b1aW-4wd4A:
undetectable		 5b1aN-4wd4A:
19.21
5b1aW-4wd4A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wo4 ANTIGEN-PRESENTING
GLYCOPROTEIN CD1D

(Homo sapiens) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		4 PHE A 114
TYR A  73
ARG A  74
THR A  78
 JLS  A 310 (-4.8A)
JLS  A 310 (-3.9A)
None
None
 0.95A 5b1aN-4wo4A:
undetectable
5b1aW-4wo4A:
undetectable		 5b1aN-4wo4A:
19.41
5b1aW-4wo4A:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 4

(Drosophila
melanogaster) 		PF13191
(AAA_16)
PF14629
(ORC4_C) 		4 ILE D 143
LEU D 178
TYR D 250
THR D  24
 None
 0.96A 5b1aN-4xgcD:
undetectable
5b1aW-4xgcD:
undetectable		 5b1aN-4xgcD:
21.64
5b1aW-4xgcD:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk3 SERPIN B3

(Homo sapiens) 		PF00079
(Serpin) 		4 ILE A 307
LEU A 325
PHE A 308
THR A  35
 None
 0.93A 5b1aN-4zk3A:
undetectable
5b1aW-4zk3A:
undetectable		 5b1aN-4zk3A:
20.65
5b1aW-4zk3A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo0 PROTEIN REP68

(Adeno-associated
dependoparvovirus
A) 		PF08724
(Rep_N) 		4 ILE A   7
LEU A 109
PHE A 132
THR A  65
 None
 1.04A 5b1aN-4zo0A:
undetectable
5b1aW-4zo0A:
undetectable		 5b1aN-4zo0A:
16.50
5b1aW-4zo0A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu9 ELONGATION FACTOR
SELB

(Aquifex
aeolicus) 		PF00009
(GTP_EFTU)
PF09107
(SelB-wing_3) 		4 ILE A 164
LEU A  57
PHE A  50
THR A  22
 None
 0.87A 5b1aN-4zu9A:
undetectable
5b1aW-4zu9A:
undetectable		 5b1aN-4zu9A:
20.62
5b1aW-4zu9A:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo sapiens) 		PF00083
(Sugar_tr) 		4 ILE A 388
PHE A 387
ARG A 454
THR A 333
 None
 1.04A 5b1aN-5c65A:
0.7
5b1aW-5c65A:
undetectable		 5b1aN-5c65A:
24.43
5b1aW-5c65A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)

(synthetic
construct) 		PF00079
(Serpin) 		4 ILE A 225
LEU A 341
ARG A 345
THR A   9
 None
 1.05A 5b1aN-5ce0A:
undetectable
5b1aW-5ce0A:
undetectable		 5b1aN-5ce0A:
20.49
5b1aW-5ce0A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19

(Escherichia
coli;
Tetrahymena
thermophila) 		PF13416
(SBP_bac_8) 		4 ILE A 499
LEU A 509
PHE A 474
THR A 385
 None
None
None
SO4  A 604 (-4.0A)
 0.98A 5b1aN-5dfmA:
2.0
5b1aW-5dfmA:
undetectable		 5b1aN-5dfmA:
21.09
5b1aW-5dfmA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B

(Neotoma lepida) 		PF00067
(p450) 		4 ILE A 453
PHE A 157
ARG A 308
THR A 175
 None
 1.04A 5b1aN-5e0eA:
undetectable
5b1aW-5e0eA:
undetectable		 5b1aN-5e0eA:
21.92
5b1aW-5e0eA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed8 MKIAA0668 PROTEIN

(Mus musculus) 		PF07738
(Sad1_UNC) 		4 ILE A 630
LEU A 644
PHE A 661
ARG A 692
 None
 0.95A 5b1aN-5ed8A:
undetectable
5b1aW-5ed8A:
undetectable		 5b1aN-5ed8A:
19.08
5b1aW-5ed8A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edj FRPC OPERON PROTEIN

(Neisseria
meningitidis) 		PF06901
(FrpC) 		4 ILE A  72
PHE A  63
ARG A  79
THR A  81
 None
 0.96A 5b1aN-5edjA:
undetectable
5b1aW-5edjA:
undetectable		 5b1aN-5edjA:
16.42
5b1aW-5edjA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gn1 ATP-DEPENDENT
HELICASE FUN30

(Saccharomyces
cerevisiae) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 ILE A 868
LEU A1115
TYR A 830
THR A1075
 None
 1.05A 5b1aN-5gn1A:
2.5
5b1aW-5gn1A:
undetectable		 5b1aN-5gn1A:
19.16
5b1aW-5gn1A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hlj VP24

(White spot
syndrome virus) 		PF12175
(WSS_VP) 		4 ILE A 183
LEU A 119
PHE A 179
THR A  52
 None
 1.06A 5b1aN-5hljA:
undetectable
5b1aW-5hljA:
undetectable		 5b1aN-5hljA:
17.00
5b1aW-5hljA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipw OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 ILE A 400
LEU A 404
PHE A 405
ARG A 366
 None
 1.07A 5b1aN-5ipwA:
undetectable
5b1aW-5ipwA:
undetectable		 5b1aN-5ipwA:
20.41
5b1aW-5ipwA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		4 ILE A 490
LEU A 503
ARG A 604
THR A 530
 None
 0.94A 5b1aN-5mqsA:
0.8
5b1aW-5mqsA:
undetectable		 5b1aN-5mqsA:
17.25
5b1aW-5mqsA:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nz7 CELLODEXTRIN
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 ILE A 628
LEU A 792
TYR A 723
THR A 729
 None
 1.03A 5b1aN-5nz7A:
undetectable
5b1aW-5nz7A:
undetectable		 5b1aN-5nz7A:
18.92
5b1aW-5nz7A:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvr PILO PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 ILE A 116
LEU A 121
PHE A 160
THR A 172
 None
None
None
MLY  A 196 ( 4.3A)
 1.06A 5b1aN-5uvrA:
undetectable
5b1aW-5uvrA:
undetectable		 5b1aN-5uvrA:
undetectable
5b1aW-5uvrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vft PROTEASOME SUBUNIT
BETA TYPE-4

(Homo sapiens) 		no annotation 4 ILE T 189
LEU T 203
PHE T 187
ARG T 171
 None
 1.04A 5b1aN-5vftT:
undetectable
5b1aW-5vftT:
undetectable		 5b1aN-5vftT:
undetectable
5b1aW-5vftT:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5f TAIL TUBE PROTEIN
GP19

(Enterobacteria
phage T4 sensu
lato) 		PF06841
(Phage_T4_gp19) 		4 ILE A  25
LEU A  28
PHE A  32
THR A 156
 None
 1.04A 5b1aN-5w5fA:
undetectable
5b1aW-5w5fA:
undetectable		 5b1aN-5w5fA:
15.76
5b1aW-5w5fA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 4 ILE A 361
LEU A 367
TYR A 414
THR A 384
 None
 1.03A 5b1aN-5wp5A:
1.4
5b1aW-5wp5A:
undetectable		 5b1aN-5wp5A:
20.45
5b1aW-5wp5A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4r S PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		no annotation 4 ILE A 250
LEU A 273
TYR A 144
THR A 178
 NAG  A 502 ( 4.3A)
None
None
None
 1.05A 5b1aN-5x4rA:
undetectable
5b1aW-5x4rA:
undetectable		 5b1aN-5x4rA:
19.89
5b1aW-5x4rA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x59 S PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind) 		4 ILE A 250
LEU A 273
TYR A 144
THR A 178
 NAG  A1402 ( 4.5A)
None
None
None
 1.06A 5b1aN-5x59A:
undetectable
5b1aW-5x59A:
undetectable		 5b1aN-5x59A:
16.77
5b1aW-5x59A:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhu FERREDOXIN--NADP
REDUCTASE

(Bacillus
subtilis) 		no annotation 4 ILE A 223
LEU A 216
ARG A 157
THR A 182
 None
 1.07A 5b1aN-5xhuA:
undetectable
5b1aW-5xhuA:
undetectable		 5b1aN-5xhuA:
undetectable
5b1aW-5xhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xu1 ABC TRANSPORTER
ATP-BINDING PROTEIN

(Streptococcus
pneumoniae) 		no annotation 4 ILE A  88
LEU A 167
PHE A  90
THR A  59
 None
 0.76A 5b1aN-5xu1A:
undetectable
5b1aW-5xu1A:
undetectable		 5b1aN-5xu1A:
undetectable
5b1aW-5xu1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9h SAFD,PUTATIVE OUTER
MEMBRANE
PROTEIN,PUTATIVE
OUTER MEMBRANE
PROTEIN,PUTATIVE
OUTER MEMBRANE
PROTEIN

(Salmonella
enterica) 		no annotation 4 ILE A 462
LEU A 332
PHE A 464
THR A 421
 None
 1.06A 5b1aN-5y9hA:
undetectable
5b1aW-5y9hA:
undetectable		 5b1aN-5y9hA:
22.02
5b1aW-5y9hA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydp TETR TRANSCRIPTIONAL
REGULATORY PROTEIN

(Dietzia sp.
DQ12-45-1b) 		PF00440
(TetR_N) 		4 ILE A 205
LEU A 108
ARG A 181
THR A 153
 None
 0.96A 5b1aN-5ydpA:
undetectable
5b1aW-5ydpA:
undetectable		 5b1aN-5ydpA:
18.45
5b1aW-5ydpA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 4 ILE 2 885
LEU 2 845
PHE 2 893
ARG 2 166
 None
 1.03A 5b1aN-5zvs2:
undetectable
5b1aW-5zvs2:
undetectable		 5b1aN-5zvs2:
undetectable
5b1aW-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5v TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5

(Oryctolagus
cuniculus) 		no annotation 4 ILE A 183
LEU A 182
ARG A 190
THR A 198
 None
 1.05A 5b1aN-6b5vA:
undetectable
5b1aW-6b5vA:
undetectable		 5b1aN-6b5vA:
undetectable
5b1aW-6b5vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gu8 -

(-) 		no annotation 4 ILE A 206
LEU A 209
PHE A 210
ARG A  75
 None
 1.02A 5b1aN-6gu8A:
undetectable
5b1aW-6gu8A:
undetectable		 5b1aN-6gu8A:
undetectable
5b1aW-6gu8A:
undetectable