SIMILAR PATTERNS OF AMINO ACIDS FOR 5B1A_P_CHDP305

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1914 SIGNAL RECOGNITION
PARTICLE 9/14 FUSION
PROTEIN

(Mus musculus) 		PF02290
(SRP14)
PF05486
(SRP9-21) 		4 LEU A2086
PHE A2017
LEU A2013
PHE A2009
 None
 0.82A 5b1aP-1914A:
0.8
5b1aW-1914A:
undetectable		 5b1aP-1914A:
19.40
5b1aW-1914A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1agx GLUTAMINASE-ASPARAGI
NASE

(Acinetobacter
glutaminasificans) 		PF00710
(Asparaginase) 		4 LEU A 313
PHE A 205
LEU A 104
PHE A 100
 None
 0.94A 5b1aP-1agxA:
undetectable
5b1aW-1agxA:
0.0		 5b1aP-1agxA:
21.25
5b1aW-1agxA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1buc BUTYRYL-COA
DEHYDROGENASE

(Megasphaera
elsdenii) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ARG A  31
LEU A  41
PHE A  19
LEU A  24
 None
 0.97A 5b1aP-1bucA:
3.8
5b1aW-1bucA:
0.0		 5b1aP-1bucA:
17.69
5b1aW-1bucA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 LEU A 164
PHE A 175
LEU A 179
PHE A 183
 None
 0.72A 5b1aP-1dj3A:
undetectable
5b1aW-1dj3A:
0.0		 5b1aP-1dj3A:
19.00
5b1aW-1dj3A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 LEU A 200
PHE A 183
LEU A 179
PHE A 175
 None
 0.70A 5b1aP-1dj3A:
undetectable
5b1aW-1dj3A:
0.0		 5b1aP-1dj3A:
19.00
5b1aW-1dj3A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE

(Escherichia
coli) 		PF00982
(Glyco_transf_20) 		5 GLN A  96
PHE A  97
PHE A  79
LEU A  84
PHE A  88
 None
 1.38A 5b1aP-1gz5A:
undetectable
5b1aW-1gz5A:
0.0		 5b1aP-1gz5A:
19.91
5b1aW-1gz5A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.82A 5b1aP-1hkkA:
0.3
5b1aW-1hkkA:
0.0		 5b1aP-1hkkA:
21.66
5b1aW-1hkkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji6 PESTICIDIAL CRYSTAL
PROTEIN CRY3BB

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 LEU A 137
GLN A 138
PHE A 141
PHE A 178
 None
 0.94A 5b1aP-1ji6A:
2.9
5b1aW-1ji6A:
0.0		 5b1aP-1ji6A:
19.52
5b1aW-1ji6A:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkw CYCLIN H

(Homo sapiens) 		PF00134
(Cyclin_N)
PF16899
(Cyclin_C_2) 		4 ARG A 102
LEU A 106
PHE A 110
LEU A 129
 None
 0.88A 5b1aP-1jkwA:
0.7
5b1aW-1jkwA:
0.0		 5b1aP-1jkwA:
20.52
5b1aW-1jkwA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js6 DOPA DECARBOXYLASE

(Sus scrofa) 		PF00282
(Pyridoxal_deC) 		4 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.92A 5b1aP-1js6A:
undetectable
5b1aW-1js6A:
0.0		 5b1aP-1js6A:
19.84
5b1aW-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1juv DIHYDROFOLATE
REDUCTASE

(Escherichia
virus T4) 		PF00186
(DHFR_1) 		4 LEU A  20
GLN A 159
PHE A  22
LEU A 165
 None
None
NDP  A 194 (-3.6A)
None
 0.94A 5b1aP-1juvA:
undetectable
5b1aW-1juvA:
undetectable		 5b1aP-1juvA:
18.99
5b1aW-1juvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kl7 THREONINE SYNTHASE

(Saccharomyces
cerevisiae) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.79A 5b1aP-1kl7A:
undetectable
5b1aW-1kl7A:
undetectable		 5b1aP-1kl7A:
21.24
5b1aW-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m33 BIOH PROTEIN

(Escherichia
coli) 		PF00561
(Abhydrolase_1) 		4 LEU A 132
GLN A 131
PHE A 128
LEU A 176
 None
 0.94A 5b1aP-1m33A:
undetectable
5b1aW-1m33A:
undetectable		 5b1aP-1m33A:
20.57
5b1aW-1m33A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrv GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 10

(Homo sapiens) 		PF00017
(SH2) 		4 GLN A 485
PHE A 484
LEU A 512
PHE A 506
 None
 0.92A 5b1aP-1nrvA:
undetectable
5b1aW-1nrvA:
undetectable		 5b1aP-1nrvA:
16.86
5b1aW-1nrvA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		5 LEU A 277
GLN A   4
PHE A 284
PHE A 290
PHE A 222
 None
 1.37A 5b1aP-1oltA:
undetectable
5b1aW-1oltA:
undetectable		 5b1aP-1oltA:
20.00
5b1aW-1oltA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovl ORPHAN NUCLEAR
RECEPTOR NURR1 (MSE
496, 511)

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU B 570
GLN B 571
PHE B 574
PHE B 592
 None
 0.68A 5b1aP-1ovlB:
undetectable
5b1aW-1ovlB:
undetectable		 5b1aP-1ovlB:
19.94
5b1aW-1ovlB:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovl ORPHAN NUCLEAR
RECEPTOR NURR1 (MSE
496, 511)

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU B 570
PHE B 574
PHE B 592
LEU B 596
 None
 0.79A 5b1aP-1ovlB:
undetectable
5b1aW-1ovlB:
undetectable		 5b1aP-1ovlB:
19.94
5b1aW-1ovlB:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovl ORPHAN NUCLEAR
RECEPTOR NURR1 (MSE
496, 511)

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU B 570
PHE B 592
LEU B 596
PHE B 598
 None
 0.94A 5b1aP-1ovlB:
undetectable
5b1aW-1ovlB:
undetectable		 5b1aP-1ovlB:
19.94
5b1aW-1ovlB:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR

(Homo sapiens) 		PF02089
(Palm_thioest) 		4 LEU A  45
PHE A  46
LEU A  80
PHE A 173
 GOL  A1616 ( 4.9A)
None
None
None
 0.89A 5b1aP-1pjaA:
undetectable
5b1aW-1pjaA:
undetectable		 5b1aP-1pjaA:
22.12
5b1aW-1pjaA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 418
GLN A 420
PHE A 501
LEU A 473
 None
 0.84A 5b1aP-1snxA:
2.5
5b1aW-1snxA:
undetectable		 5b1aP-1snxA:
19.44
5b1aW-1snxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svr SEVERIN

(Dictyostelium
discoideum) 		PF00626
(Gelsolin) 		4 GLN A 200
PHE A 201
PHE A 245
LEU A 249
 None
 0.75A 5b1aP-1svrA:
undetectable
5b1aW-1svrA:
undetectable		 5b1aP-1svrA:
17.37
5b1aW-1svrA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tyg THIAZOLE
BIOSYNTHESIS PROTEIN
THIG

(Bacillus
subtilis) 		PF05690
(ThiG) 		4 LEU A 158
PHE A 157
PHE A 142
LEU A 168
 None
 0.90A 5b1aP-1tygA:
undetectable
5b1aW-1tygA:
undetectable		 5b1aP-1tygA:
21.65
5b1aW-1tygA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8v GAMMA-AMINOBUTYRATE
METABOLISM
DEHYDRATASE/ISOMERAS
E

(Clostridium
aminobutyricum) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 ARG A 433
LEU A 437
LEU A 391
PHE A 422
 None
 0.96A 5b1aP-1u8vA:
3.8
5b1aW-1u8vA:
undetectable		 5b1aP-1u8vA:
19.70
5b1aW-1u8vA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vku ACYL CARRIER PROTEIN

(Thermotoga
maritima) 		PF00550
(PP-binding) 		4 LEU A  70
PHE A  48
LEU A  44
PHE A  36
 None
 0.91A 5b1aP-1vkuA:
undetectable
5b1aW-1vkuA:
undetectable		 5b1aP-1vkuA:
13.64
5b1aW-1vkuA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.80A 5b1aP-1wb0A:
undetectable
5b1aW-1wb0A:
undetectable		 5b1aP-1wb0A:
19.69
5b1aW-1wb0A:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wrj METHYLATED-DNA--PROT
EIN-CYSTEINE
METHYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF01035
(DNA_binding_1) 		4 LEU A  60
PHE A  45
LEU A  49
PHE A  53
 None
 0.97A 5b1aP-1wrjA:
undetectable
5b1aW-1wrjA:
undetectable		 5b1aP-1wrjA:
16.60
5b1aW-1wrjA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		4 LEU A   5
PHE A 235
LEU A 231
PHE A 227
 None
 0.89A 5b1aP-1xw8A:
undetectable
5b1aW-1xw8A:
undetectable		 5b1aP-1xw8A:
18.97
5b1aW-1xw8A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		5 LEU A 188
GLN A 186
PHE A 227
LEU A 231
PHE A 235
 None
 1.12A 5b1aP-1xw8A:
undetectable
5b1aW-1xw8A:
undetectable		 5b1aP-1xw8A:
18.97
5b1aW-1xw8A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4u CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.91A 5b1aP-1y4uA:
undetectable
5b1aW-1y4uA:
undetectable		 5b1aP-1y4uA:
16.99
5b1aW-1y4uA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zes PHOSPHATE REGULON
TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOB

(Escherichia
coli) 		PF00072
(Response_reg) 		4 LEU A  42
GLN A  41
PHE A  64
LEU A  68
 None
 0.76A 5b1aP-1zesA:
undetectable
5b1aW-1zesA:
undetectable		 5b1aP-1zesA:
16.80
5b1aW-1zesA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buk COAT PROTEIN

(unidentified
tobacco
necrosis virus) 		PF03898
(TNV_CP) 		4 LEU A 174
GLN A  45
PHE A 172
PHE A  90
 None
 0.84A 5b1aP-2bukA:
undetectable
5b1aW-2bukA:
undetectable		 5b1aP-2bukA:
21.37
5b1aW-2bukA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cmh SPERMIDINE SYNTHASE

(Helicobacter
pylori) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 LEU A  90
GLN A  89
PHE A 144
LEU A 142
 None
 0.91A 5b1aP-2cmhA:
undetectable
5b1aW-2cmhA:
undetectable		 5b1aP-2cmhA:
23.63
5b1aW-2cmhA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpy FLAGELLUM-SPECIFIC
ATP SYNTHASE

(Salmonella
enterica) 		PF00006
(ATP-synt_ab) 		4 LEU A 428
PHE A 431
PHE A 391
LEU A 395
 None
 0.94A 5b1aP-2dpyA:
undetectable
5b1aW-2dpyA:
undetectable		 5b1aP-2dpyA:
20.50
5b1aW-2dpyA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		5 LEU X 495
GLN X 542
PHE X 543
PHE X 343
LEU X 446
 None
 1.42A 5b1aP-2epkX:
3.2
5b1aW-2epkX:
undetectable		 5b1aP-2epkX:
16.85
5b1aW-2epkX:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fnu AMINOTRANSFERASE

(Helicobacter
pylori) 		PF01041
(DegT_DnrJ_EryC1) 		4 LEU A 243
GLN A 242
PHE A  37
LEU A  41
 None
 0.70A 5b1aP-2fnuA:
undetectable
5b1aW-2fnuA:
undetectable		 5b1aP-2fnuA:
20.38
5b1aW-2fnuA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fre NAD(P)H-FLAVIN
OXIDOREDUCTASE

(Agrobacterium
fabrum) 		PF00881
(Nitroreductase) 		4 LEU A  73
GLN A  79
PHE A  90
LEU A 147
 None
 0.93A 5b1aP-2freA:
undetectable
5b1aW-2freA:
undetectable		 5b1aP-2freA:
19.72
5b1aW-2freA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gnp TRANSCRIPTIONAL
REGULATOR

(Streptococcus
pneumoniae) 		PF04198
(Sugar-bind) 		4 LEU A 258
GLN A 259
LEU A 225
PHE A 230
 None
 0.85A 5b1aP-2gnpA:
undetectable
5b1aW-2gnpA:
undetectable		 5b1aP-2gnpA:
19.19
5b1aW-2gnpA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq0 CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90) 		4 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.91A 5b1aP-2gq0A:
undetectable
5b1aW-2gq0A:
undetectable		 5b1aP-2gq0A:
20.30
5b1aW-2gq0A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtr CHROMODOMAIN Y-LIKE
PROTEIN

(Homo sapiens) 		PF00378
(ECH_1) 		4 ARG A 219
LEU A 226
GLN A 228
LEU A 122
 None
 0.93A 5b1aP-2gtrA:
undetectable
5b1aW-2gtrA:
undetectable		 5b1aP-2gtrA:
20.20
5b1aW-2gtrA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2haj DNA PRIMASE

(Escherichia
coli) 		PF08278
(DnaG_DnaB_bind) 		4 LEU A 454
PHE A 535
LEU A 539
PHE A 543
 None
 0.88A 5b1aP-2hajA:
undetectable
5b1aW-2hajA:
undetectable		 5b1aP-2hajA:
19.01
5b1aW-2hajA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi3 HOMEODOMAIN-ONLY
PROTEIN

(Mus musculus) 		PF00046
(Homeobox) 		4 ARG A  59
LEU A  55
GLN A  53
PHE A  51
 None
 0.93A 5b1aP-2hi3A:
undetectable
5b1aW-2hi3A:
undetectable		 5b1aP-2hi3A:
13.41
5b1aW-2hi3A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxg L-ARABINOSE
ISOMERASE

(Escherichia
coli) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		5 LEU A 296
GLN A 294
PHE A 303
PHE A 275
LEU A 267
 None
 1.40A 5b1aP-2hxgA:
undetectable
5b1aW-2hxgA:
undetectable		 5b1aP-2hxgA:
20.04
5b1aW-2hxgA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis) 		PF13419
(HAD_2) 		5 LEU A 106
PHE A   7
PHE A 134
LEU A 130
PHE A 123
 None
 1.43A 5b1aP-2i6xA:
undetectable
5b1aW-2i6xA:
undetectable		 5b1aP-2i6xA:
20.30
5b1aW-2i6xA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibd POSSIBLE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		4 LEU A 131
PHE A 135
PHE A  74
LEU A  70
 None
 0.89A 5b1aP-2ibdA:
undetectable
5b1aW-2ibdA:
undetectable		 5b1aP-2ibdA:
24.73
5b1aW-2ibdA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iop CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.89A 5b1aP-2iopA:
undetectable
5b1aW-2iopA:
undetectable		 5b1aP-2iopA:
16.83
5b1aW-2iopA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 LEU A  60
GLN A  59
PHE A  99
LEU A 128
 None
 0.94A 5b1aP-2iujA:
undetectable
5b1aW-2iujA:
undetectable		 5b1aP-2iujA:
14.45
5b1aW-2iujA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 1

(Mus musculus) 		PF04099
(Sybindin) 		4 ARG C  94
GLN C  65
PHE C  64
PHE C  61
 None
 0.89A 5b1aP-2j3tC:
undetectable
5b1aW-2j3tC:
undetectable		 5b1aP-2j3tC:
20.75
5b1aW-2j3tC:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nt8 COBALAMIN
ADENOSYLTRANSFERASE

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		4 LEU A  95
PHE A 154
LEU A 158
PHE A 162
 None
 0.84A 5b1aP-2nt8A:
2.8
5b1aW-2nt8A:
undetectable		 5b1aP-2nt8A:
21.30
5b1aW-2nt8A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opt ACTII PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 ARG A  75
LEU A  79
PHE A  83
LEU A  49
 None
 0.71A 5b1aP-2optA:
3.1
5b1aW-2optA:
undetectable		 5b1aP-2optA:
23.19
5b1aW-2optA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n SKP1-LIKE PROTEIN 1A
TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF01466
(Skp1)
PF03931
(Skp1_POZ)
PF12937
(F-box-like) 		4 PHE A  99
PHE B   9
LEU B  14
PHE B  18
 None
 0.87A 5b1aP-2p1nA:
undetectable
5b1aW-2p1nA:
undetectable		 5b1aP-2p1nA:
18.58
5b1aW-2p1nA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6v TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 4

(Homo sapiens) 		PF07531
(TAFH) 		4 LEU A 622
GLN A 624
PHE A 636
LEU A 640
 None
 0.89A 5b1aP-2p6vA:
undetectable
5b1aW-2p6vA:
undetectable		 5b1aP-2p6vA:
18.34
5b1aW-2p6vA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pn1 CARBAMOYLPHOSPHATE
SYNTHASE LARGE
SUBUNIT

(Exiguobacterium
sibiricum) 		PF02655
(ATP-grasp_3) 		4 LEU A 289
GLN A 288
PHE A  21
LEU A  76
 None
 0.85A 5b1aP-2pn1A:
undetectable
5b1aW-2pn1A:
undetectable		 5b1aP-2pn1A:
20.12
5b1aW-2pn1A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2r GLUCOKINASE 1,
PUTATIVE

(Trypanosoma
cruzi) 		PF02685
(Glucokinase) 		5 ARG A  83
LEU A  24
PHE A  26
PHE A  39
LEU A  15
 None
 1.36A 5b1aP-2q2rA:
undetectable
5b1aW-2q2rA:
undetectable		 5b1aP-2q2rA:
21.78
5b1aW-2q2rA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q66 POLY(A) POLYMERASE

(Saccharomyces
cerevisiae) 		PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central) 		4 LEU A  58
GLN A  60
PHE A 120
LEU A 124
 None
 0.92A 5b1aP-2q66A:
undetectable
5b1aW-2q66A:
undetectable		 5b1aP-2q66A:
18.08
5b1aW-2q66A:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		4 LEU A 216
GLN A 215
PHE A 154
LEU A 199
 None
 0.90A 5b1aP-2q6zA:
undetectable
5b1aW-2q6zA:
undetectable		 5b1aP-2q6zA:
20.71
5b1aW-2q6zA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2riu 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Candida
albicans) 		PF00926
(DHBP_synthase) 		4 LEU A 113
PHE A  93
PHE A 123
LEU A  70
 None
 0.88A 5b1aP-2riuA:
undetectable
5b1aW-2riuA:
undetectable		 5b1aP-2riuA:
21.66
5b1aW-2riuA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 LEU A1146
GLN A1142
PHE A1180
LEU A1184
 None
 0.97A 5b1aP-2xt6A:
undetectable
5b1aW-2xt6A:
undetectable		 5b1aP-2xt6A:
12.79
5b1aW-2xt6A:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0n MALE-SPECIFIC LETHAL
3 HOMOLOG

(Homo sapiens) 		PF05712
(MRG) 		4 LEU A 180
PHE A 499
LEU A 491
PHE A 487
 None
 0.96A 5b1aP-2y0nA:
undetectable
5b1aW-2y0nA:
undetectable		 5b1aP-2y0nA:
18.22
5b1aW-2y0nA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 818
PHE A 822
PHE A 832
LEU A 836
 None
 0.73A 5b1aP-2yd0A:
undetectable
5b1aW-2yd0A:
undetectable		 5b1aP-2yd0A:
14.57
5b1aW-2yd0A:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2s RPOE, ECF SIGE

(Rhodobacter
sphaeroides) 		PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4) 		4 ARG A  73
LEU A 176
GLN A 178
LEU A 103
 None
 0.86A 5b1aP-2z2sA:
undetectable
5b1aW-2z2sA:
undetectable		 5b1aP-2z2sA:
18.66
5b1aW-2z2sA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zou SPONDIN-1

(Homo sapiens) 		PF02014
(Reeler) 		5 LEU A 177
GLN A 172
PHE A 171
LEU A  82
PHE A  90
 EDO  A   6 (-3.8A)
EDO  A   6 (-4.9A)
None
None
None
 1.25A 5b1aP-2zouA:
undetectable
5b1aW-2zouA:
undetectable		 5b1aP-2zouA:
15.85
5b1aW-2zouA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		5 ARG A 105
LEU A 118
GLN A 130
PHE A 120
LEU A 308
 None
 1.47A 5b1aP-3actA:
undetectable
5b1aW-3actA:
undetectable		 5b1aP-3actA:
13.52
5b1aW-3actA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ba3 PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-LIKE PROTEIN

(Lactobacillus
plantarum) 		no annotation 5 LEU A 123
GLN A  87
PHE A 121
PHE A  45
LEU A  18
 None
 0.84A 5b1aP-3ba3A:
undetectable
5b1aW-3ba3A:
undetectable		 5b1aP-3ba3A:
21.19
5b1aW-3ba3A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgh PUTATIVE
NEURAMINYLLACTOSE-BI
NDING HEMAGGLUTININ
HOMOLOG

(Helicobacter
pylori) 		PF05211
(NLBH) 		4 GLN A  78
PHE A  81
PHE A  44
LEU A  42
 None
 0.94A 5b1aP-3bghA:
2.1
5b1aW-3bghA:
undetectable		 5b1aP-3bghA:
19.22
5b1aW-3bghA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr8 SULFATE
ADENYLYLTRANSFERASE,
ADENYLYLSULFATE
KINASE

(Thiobacillus
denitrificans) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A  74
GLN A  73
PHE A  79
LEU A  56
 None
 0.94A 5b1aP-3cr8A:
undetectable
5b1aW-3cr8A:
undetectable		 5b1aP-3cr8A:
20.53
5b1aW-3cr8A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1d RNA-INDUCED
TRANSCRIPTIONAL
SILENCING COMPLEX
PROTEIN TAS3

(Schizosaccharomyces
pombe) 		no annotation 5 LEU A 477
GLN A 475
PHE A 473
LEU A 443
PHE A 449
 None
 1.49A 5b1aP-3d1dA:
undetectable
5b1aW-3d1dA:
undetectable		 5b1aP-3d1dA:
19.47
5b1aW-3d1dA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		4 LEU C  73
PHE C  75
PHE C   7
LEU C 176
 None
 0.90A 5b1aP-3degC:
undetectable
5b1aW-3degC:
undetectable		 5b1aP-3degC:
17.43
5b1aW-3degC:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT

(Candida
albicans) 		PF00432
(Prenyltrans) 		4 LEU B   4
GLN B   3
PHE B 365
LEU B 357
 None
 0.96A 5b1aP-3draB:
undetectable
5b1aW-3draB:
undetectable		 5b1aP-3draB:
18.70
5b1aW-3draB:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evz METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF05175
(MTS) 		4 LEU A 202
PHE A 153
LEU A 186
PHE A 182
 None
 0.97A 5b1aP-3evzA:
undetectable
5b1aW-3evzA:
undetectable		 5b1aP-3evzA:
19.78
5b1aW-3evzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eyk HEMAGGLUTININ HA1
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 LEU A 118
GLN A  80
PHE A 120
LEU A 112
 None
 0.86A 5b1aP-3eykA:
undetectable
5b1aW-3eykA:
undetectable		 5b1aP-3eykA:
21.21
5b1aW-3eykA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1z PUTATIVE LYSYL-TRNA
SYNTHETASE

(Salmonella
enterica) 		PF00152
(tRNA-synt_2) 		5 ARG A 188
LEU A 192
GLN A 193
PHE A 196
PHE A 153
 None
 1.11A 5b1aP-3g1zA:
undetectable
5b1aW-3g1zA:
undetectable		 5b1aP-3g1zA:
20.94
5b1aW-3g1zA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO

(Thermus
thermophilus) 		PF01134
(GIDA) 		4 LEU A 289
GLN A 291
PHE A 199
LEU A 203
 None
 0.87A 5b1aP-3g5sA:
undetectable
5b1aW-3g5sA:
undetectable		 5b1aP-3g5sA:
20.48
5b1aW-3g5sA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaj COBALAMIN
ADENOSYLTRANSFERASE
PDUO-LIKE PROTEIN

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		4 LEU A  95
PHE A 154
LEU A 158
PHE A 162
 None
 0.84A 5b1aP-3gajA:
2.8
5b1aW-3gajA:
undetectable		 5b1aP-3gajA:
21.16
5b1aW-3gajA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzg MOLYBDATE-BINDING
PERIPLASMIC PROTEIN
PERMEASE

(Xanthomonas
citri) 		PF13531
(SBP_bac_11) 		5 LEU A  80
PHE A 230
PHE A 225
LEU A 216
PHE A 212
 None
 1.32A 5b1aP-3gzgA:
undetectable
5b1aW-3gzgA:
undetectable		 5b1aP-3gzgA:
24.09
5b1aW-3gzgA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4l DNA MISMATCH REPAIR
PROTEIN PMS1

(Saccharomyces
cerevisiae) 		PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3) 		4 LEU A 181
GLN A 180
PHE A 192
LEU A  55
 None
 0.79A 5b1aP-3h4lA:
undetectable
5b1aW-3h4lA:
undetectable		 5b1aP-3h4lA:
19.18
5b1aW-3h4lA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 LEU A 196
GLN A 193
PHE A 200
LEU A 162
 None
 0.90A 5b1aP-3hjrA:
undetectable
5b1aW-3hjrA:
undetectable		 5b1aP-3hjrA:
17.67
5b1aW-3hjrA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 21

(Homo sapiens) 		PF00443
(UCH) 		4 LEU A 378
GLN A 453
PHE A 397
LEU A 400
 None
 0.87A 5b1aP-3i3tA:
undetectable
5b1aW-3i3tA:
undetectable		 5b1aP-3i3tA:
21.07
5b1aW-3i3tA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.95A 5b1aP-3iv0A:
1.8
5b1aW-3iv0A:
undetectable		 5b1aP-3iv0A:
20.57
5b1aW-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE

(Drosophila
melanogaster) 		PF00282
(Pyridoxal_deC) 		4 LEU A 114
PHE A 354
LEU A 357
PHE A 361
 None
 0.93A 5b1aP-3k40A:
undetectable
5b1aW-3k40A:
undetectable		 5b1aP-3k40A:
19.79
5b1aW-3k40A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		4 LEU A 106
GLN A 108
PHE A  85
LEU A  89
 None
 0.86A 5b1aP-3l6aA:
undetectable
5b1aW-3l6aA:
undetectable		 5b1aP-3l6aA:
20.70
5b1aW-3l6aA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS

(Streptomyces
sp. CK4412) 		PF00975
(Thioesterase) 		4 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.84A 5b1aP-3lcrA:
undetectable
5b1aW-3lcrA:
undetectable		 5b1aP-3lcrA:
20.45
5b1aW-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE

(Coccidioides
immitis) 		PF13409
(GST_N_2)
PF14497
(GST_C_3) 		4 LEU A   8
PHE A   6
PHE A  24
LEU A  20
 None
 0.95A 5b1aP-3lg6A:
2.8
5b1aW-3lg6A:
undetectable		 5b1aP-3lg6A:
20.29
5b1aW-3lg6A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvu TENA FAMILY
TRANSCRIPTIONAL
REGULATOR

(Ruegeria sp.
TM1040) 		PF03070
(TENA_THI-4) 		4 LEU A 204
PHE A 208
LEU A 187
PHE A 195
 None
None
None
EDO  A 231 (-3.8A)
 0.94A 5b1aP-3mvuA:
undetectable
5b1aW-3mvuA:
undetectable		 5b1aP-3mvuA:
20.30
5b1aW-3mvuA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mw4 NEUREXIN-2-BETA

(Mus musculus) 		PF02210
(Laminin_G_2) 		4 LEU A 226
GLN A 225
PHE A 222
LEU A 124
 None
 0.89A 5b1aP-3mw4A:
undetectable
5b1aW-3mw4A:
undetectable		 5b1aP-3mw4A:
20.97
5b1aW-3mw4A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbu GLUCOSE-6-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00342
(PGI) 		4 LEU A  15
GLN A  16
PHE A  19
LEU A  66
 None
 0.83A 5b1aP-3nbuA:
undetectable
5b1aW-3nbuA:
undetectable		 5b1aP-3nbuA:
18.63
5b1aW-3nbuA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhe UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2

(Homo sapiens) 		PF00443
(UCH) 		4 LEU A 419
GLN A 492
PHE A 438
LEU A 441
 None
 0.87A 5b1aP-3nheA:
undetectable
5b1aW-3nheA:
undetectable		 5b1aP-3nheA:
20.23
5b1aW-3nheA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nj2 DUF269-CONTAINING
PROTEIN

(Cyanothece sp.
ATCC 51142) 		PF03270
(DUF269) 		5 LEU A  40
GLN A  43
PHE A  36
LEU A 150
PHE A 144
 None
 1.31A 5b1aP-3nj2A:
undetectable
5b1aW-3nj2A:
undetectable		 5b1aP-3nj2A:
20.45
5b1aW-3nj2A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob4 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ARAH 2

(Escherichia
coli;
Arachis
duranensis) 		PF00234
(Tryp_alpha_amyl)
PF13416
(SBP_bac_8) 		4 LEU A1046
GLN A1044
PHE A1126
LEU A1130
 None
 0.94A 5b1aP-3ob4A:
undetectable
5b1aW-3ob4A:
undetectable		 5b1aP-3ob4A:
15.02
5b1aW-3ob4A:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob4 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ARAH 2

(Escherichia
coli;
Arachis
duranensis) 		PF00234
(Tryp_alpha_amyl)
PF13416
(SBP_bac_8) 		4 LEU A1046
GLN A1048
PHE A1126
LEU A1130
 None
 0.86A 5b1aP-3ob4A:
undetectable
5b1aW-3ob4A:
undetectable		 5b1aP-3ob4A:
15.02
5b1aW-3ob4A:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ofj NODULATION PROTEIN S

(Bradyrhizobium
sp. WM9) 		PF05401
(NodS) 		4 LEU A  36
GLN A  34
PHE A  58
LEU A  62
 None
 0.87A 5b1aP-3ofjA:
undetectable
5b1aW-3ofjA:
undetectable		 5b1aP-3ofjA:
21.83
5b1aW-3ofjA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqq PUTATIVE LIPOPROTEIN

(Bacteroides
ovatus) 		PF16129
(DUF4841)
PF16130
(DUF4842) 		4 LEU A 214
PHE A 152
PHE A 173
LEU A 201
 None
 0.97A 5b1aP-3oqqA:
undetectable
5b1aW-3oqqA:
undetectable		 5b1aP-3oqqA:
20.13
5b1aW-3oqqA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pja TRANSLIN

(Homo sapiens) 		PF01997
(Translin) 		4 ARG A 166
LEU A 154
PHE A 104
LEU A 108
 None
 0.95A 5b1aP-3pjaA:
3.8
5b1aW-3pjaA:
undetectable		 5b1aP-3pjaA:
20.88
5b1aW-3pjaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poy NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		4 LEU A1320
GLN A1319
PHE A1316
LEU A1188
 None
 0.87A 5b1aP-3poyA:
undetectable
5b1aW-3poyA:
undetectable		 5b1aP-3poyA:
13.35
5b1aW-3poyA:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdn PUTATIVE THIOREDOXIN
PROTEIN

(Salmonella
enterica) 		PF00085
(Thioredoxin)
PF14559
(TPR_19)
PF14561
(TPR_20) 		4 LEU A 236
PHE A 240
PHE A 258
LEU A 262
 None
 0.53A 5b1aP-3qdnA:
undetectable
5b1aW-3qdnA:
undetectable		 5b1aP-3qdnA:
21.02
5b1aW-3qdnA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF11838
(ERAP1_C) 		4 LEU A 818
PHE A 822
PHE A 832
LEU A 836
 None
 0.87A 5b1aP-3rjoA:
1.6
5b1aW-3rjoA:
undetectable		 5b1aP-3rjoA:
20.24
5b1aW-3rjoA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wi3 DNA REPLICATION
REGULATOR SLD3

(Saccharomyces
cerevisiae) 		PF08639
(SLD3) 		4 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 0.92A 5b1aP-3wi3A:
2.6
5b1aW-3wi3A:
undetectable		 5b1aP-3wi3A:
18.93
5b1aW-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvr PGM1

(Streptomyces
cirratus) 		no annotation 4 LEU A 119
PHE A  95
LEU A  91
PHE A  87
 None
 0.93A 5b1aP-3wvrA:
undetectable
5b1aW-3wvrA:
undetectable		 5b1aP-3wvrA:
19.19
5b1aW-3wvrA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME

(Mycolicibacterium
smegmatis) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 LEU A1146
GLN A1142
PHE A1180
LEU A1184
 None
MPD  A2228 (-3.2A)
None
None
 0.96A 5b1aP-3zhrA:
undetectable
5b1aW-3zhrA:
undetectable		 5b1aP-3zhrA:
14.22
5b1aW-3zhrA:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6o ALPHA-N-ACETYLGLUCOS
AMINIDASE FAMILY
PROTEIN

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		4 GLN A1276
PHE A1275
PHE A1268
LEU A1266
 None
 0.97A 5b1aP-4a6oA:
undetectable
5b1aW-4a6oA:
undetectable		 5b1aP-4a6oA:
19.10
5b1aW-4a6oA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE

(Pyrococcus
abyssi) 		PF00589
(Phage_integrase)
PF02899
(Phage_int_SAM_1) 		4 ARG A 184
LEU A 181
LEU A 191
PHE A 192
 None
 0.95A 5b1aP-4a8eA:
undetectable
5b1aW-4a8eA:
undetectable		 5b1aP-4a8eA:
19.68
5b1aW-4a8eA:
12.25