SIMILAR PATTERNS OF AMINO ACIDS FOR 5AXD_C_RBVC502_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad1 DIHYDROPTEROATE
SYNTHETASE

(Staphylococcus
aureus) 		PF00809
(Pterin_bind) 		3 THR A   4
HIS A 129
LEU A 189
 None
 0.82A 5axdC-1ad1A:
0.4		 5axdC-1ad1A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axk GLUXYN-1

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16) 		3 THR A 339
HIS A 108
LEU A 106
 None
 0.87A 5axdC-1axkA:
undetectable		 5axdC-1axkA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwy PROTEIN (HEART FATTY
ACID BINDING
PROTEIN)

(Bos taurus) 		PF00061
(Lipocalin) 		3 THR A  53
HIS A 119
LEU A 117
 None
 0.85A 5axdC-1bwyA:
0.0		 5axdC-1bwyA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0a ASPARTYL TRNA
SYNTHETASE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		3 THR A 169
HIS A 491
LEU A 521
 A  B 676 ( 3.6A)
None
None
 0.88A 5axdC-1c0aA:
0.0		 5axdC-1c0aA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		3 THR A 123
HIS A 226
LEU A 230
 None
 0.75A 5axdC-1cvrA:
4.3		 5axdC-1cvrA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgv APO CIB

(Homo sapiens) 		PF13499
(EF-hand_7) 		3 THR A  93
HIS A  23
LEU A  84
 None
 0.83A 5axdC-1dgvA:
0.0		 5axdC-1dgvA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		3 THR A 222
HIS A  94
LEU A  73
 None
 0.88A 5axdC-1dj2A:
1.3		 5axdC-1dj2A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv CYTOCHROME C1

(Saccharomyces
cerevisiae) 		PF02167
(Cytochrom_C1) 		3 THR D 114
HIS D 105
LEU D 255
 None
HEM  D   3 (-3.2A)
None
 0.81A 5axdC-1ezvD:
0.0		 5axdC-1ezvD:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1u HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Arthrobacter
globiformis) 		PF00903
(Glyoxalase) 		3 THR A 109
HIS A 155
LEU A 153
 None
MN  A 500 (-3.4A)
None
 0.75A 5axdC-1f1uA:
0.0		 5axdC-1f1uA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		3 THR A 330
HIS A 543
LEU A 548
 None
 0.82A 5axdC-1fehA:
undetectable		 5axdC-1fehA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuj PR3

(Homo sapiens) 		PF00089
(Trypsin) 		3 THR A 229
HIS A  48
LEU A 123
 None
 0.83A 5axdC-1fujA:
undetectable		 5axdC-1fujA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g6q HNRNP ARGININE
N-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF06325
(PrmA) 		3 THR 1 110
HIS 1 153
LEU 1 116
 None
 0.76A 5axdC-1g6q1:
5.4		 5axdC-1g6q1:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1goj KINESIN HEAVY CHAIN

(Neurospora
crassa) 		PF00225
(Kinesin) 		3 THR A  72
HIS A 209
LEU A 291
 None
 0.78A 5axdC-1gojA:
undetectable		 5axdC-1gojA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvz KALLIKREIN-1E2

(Equus caballus) 		PF00089
(Trypsin) 		3 THR A 229
HIS A  48
LEU A 123
 None
ACT  A1250 (-4.5A)
None
 0.88A 5axdC-1gvzA:
undetectable		 5axdC-1gvzA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i51 CASPASE-7 SUBUNIT
P11
X-LINKED INHIBITOR
OF APOPTOSIS PROTEIN

(Homo sapiens) 		PF00656
(Peptidase_C14)
no annotation 		3 THR B 225
HIS B 281
LEU E 141
 None
 0.87A 5axdC-1i51B:
undetectable		 5axdC-1i51B:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kea POSSIBLE G-T
MISMATCHES REPAIR
ENZYME

(Methanothermobacter
thermautotrophicus) 		PF00730
(HhH-GPD) 		3 THR A  32
HIS A  52
LEU A  45
 None
 0.80A 5axdC-1keaA:
undetectable		 5axdC-1keaA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgs DNA BINDING RESPONSE
REGULATOR D

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		3 THR A  19
HIS A  59
LEU A  56
 None
 0.88A 5axdC-1kgsA:
6.7		 5axdC-1kgsA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks9 2-DEHYDROPANTOATE
2-REDUCTASE

(Escherichia
coli) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		3 THR A 102
HIS A 120
LEU A  11
 None
 0.85A 5axdC-1ks9A:
7.9		 5axdC-1ks9A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lm5 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)

(Homo sapiens) 		PF00681
(Plectin) 		3 THR A2733
HIS A2662
LEU A2800
 None
 0.81A 5axdC-1lm5A:
undetectable		 5axdC-1lm5A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m72 CASPASE-1

(Spodoptera
frugiperda) 		PF00656
(Peptidase_C14) 		3 THR A  82
HIS A 148
LEU A  76
 None
 0.82A 5axdC-1m72A:
3.0		 5axdC-1m72A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		3 THR A  23
HIS A  13
LEU A  35
 None
 0.88A 5axdC-1n60A:
undetectable		 5axdC-1n60A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		3 THR A 253
HIS A 219
LEU A 304
 None
 0.87A 5axdC-1o2dA:
2.3		 5axdC-1o2dA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmn ALPHA-1-ANTICHYMOTRY
PSIN

(Homo sapiens) 		PF00079
(Serpin) 		3 THR A 238
HIS A 224
LEU A 226
 None
 0.85A 5axdC-1qmnA:
undetectable		 5axdC-1qmnA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpw PORCINE HEMOGLOBIN
(ALPHA SUBUNIT)

(Sus scrofa) 		PF00042
(Globin) 		3 THR A  39
HIS A  24
LEU A 105
 HEM  A 650 ( 4.7A)
None
None
 0.76A 5axdC-1qpwA:
undetectable		 5axdC-1qpwA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu2 ISOLEUCYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00133
(tRNA-synt_1)
PF06827
(zf-FPG_IleRS)
PF08264
(Anticodon_1) 		3 THR A 641
HIS A  67
LEU A 142
 None
MRC  A1993 (-4.1A)
None
 0.85A 5axdC-1qu2A:
undetectable		 5axdC-1qu2A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1

(Caenorhabditis
elegans) 		PF00248
(Aldo_ket_red) 		3 THR A  23
HIS A 172
LEU A 112
 None
 0.87A 5axdC-1qwkA:
undetectable		 5axdC-1qwkA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sl6 C-TYPE LECTIN
DC-SIGNR

(Homo sapiens) 		PF00059
(Lectin_C) 		3 THR A 319
HIS A 290
LEU A 303
 None
 0.87A 5axdC-1sl6A:
undetectable		 5axdC-1sl6A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B

([Haemophilus]
ducreyi) 		PF03372
(Exo_endo_phos) 		3 THR B  31
HIS B 243
LEU B  24
 None
 0.77A 5axdC-1sr4B:
undetectable		 5axdC-1sr4B:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0o VON WILLEBRAND
FACTOR

(Mus musculus) 		PF00092
(VWA) 		3 THR C 581
HIS C 616
LEU C 568
 None
 0.79A 5axdC-1u0oC:
undetectable		 5axdC-1u0oC:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 THR A 165
HIS A  53
LEU A  62
 None
 0.85A 5axdC-1uagA:
2.3		 5axdC-1uagA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur4 GALACTANASE

(Bacillus
licheniformis) 		PF07745
(Glyco_hydro_53) 		3 THR A 193
HIS A 202
LEU A 106
 None
 0.74A 5axdC-1ur4A:
undetectable		 5axdC-1ur4A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vho ENDOGLUCANASE

(Thermotoga
maritima) 		PF05343
(Peptidase_M42) 		3 THR A 160
HIS A 307
LEU A 303
 THR  A 160 ( 0.8A)
HIS  A 307 ( 1.0A)
LEU  A 303 ( 0.6A)
 0.78A 5axdC-1vhoA:
undetectable		 5axdC-1vhoA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb2 ELONGATION FACTOR
TS, MITOCHONDRIAL

(Bos taurus) 		PF00889
(EF_TS) 		3 THR B 129
HIS B 316
LEU B 269
 None
 0.84A 5axdC-1xb2B:
undetectable		 5axdC-1xb2B:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp3 ENDONUCLEASE IV

(Bacillus
anthracis) 		PF01261
(AP_endonuc_2) 		3 THR A 261
HIS A 249
LEU A 214
 None
 0.81A 5axdC-1xp3A:
undetectable		 5axdC-1xp3A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN

(Aspergillus
niger) 		PF01828
(Peptidase_A4) 		3 THR B 135
HIS B  90
LEU B  23
 None
 0.88A 5axdC-1y43B:
undetectable		 5axdC-1y43B:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR

(Homo sapiens) 		PF00089
(Trypsin) 		3 THR A 632
HIS A 438
LEU A 522
 None
 0.65A 5axdC-1ybwA:
undetectable		 5axdC-1ybwA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqd SINAPYL ALCOHOL
DEHYDROGENASE

(Populus
tremuloides) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 THR A 309
HIS A  51
LEU A 195
 None
NAP  A 500 (-3.8A)
NAP  A 500 (-3.4A)
 0.73A 5axdC-1yqdA:
8.0		 5axdC-1yqdA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli) 		PF04952
(AstE_AspA) 		3 THR A 193
HIS A 155
LEU A 302
 None
 0.70A 5axdC-1yw6A:
undetectable		 5axdC-1yw6A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxy PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE

(Streptococcus
pyogenes) 		PF04131
(NanE) 		3 THR A 165
HIS A 150
LEU A 182
 None
 0.88A 5axdC-1yxyA:
undetectable		 5axdC-1yxyA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE

(Klebsiella
aerogenes) 		PF00144
(Beta-lactamase) 		3 THR A  69
HIS A 351
LEU A 309
 None
 0.83A 5axdC-1zkjA:
undetectable		 5axdC-1zkjA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmr PHOSPHOGLYCERATE
KINASE

(Escherichia
coli) 		PF00162
(PGK) 		3 THR A  43
HIS A 152
LEU A 381
 None
 0.75A 5axdC-1zmrA:
4.2		 5axdC-1zmrA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a24 ENDOTHELIAL PAS
DOMAIN PROTEIN 1

(Homo sapiens) 		PF08447
(PAS_3) 		3 THR A  85
HIS A  32
LEU A  36
 None
 0.88A 5axdC-2a24A:
undetectable		 5axdC-2a24A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aj4 GALACTOKINASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		3 THR A 291
HIS A 396
LEU A 310
 None
 0.80A 5axdC-2aj4A:
undetectable		 5axdC-2aj4A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B
RIBOSOME BIOGENESIS
PROTEIN NOP10

(Methanocaldococcus
jannaschii) 		PF01472
(PUA)
PF01509
(TruB_N)
PF04135
(Nop10p)
PF08068
(DKCLD)
PF16198
(TruB_C_2) 		3 THR B 428
HIS A 114
LEU A 112
 None
 0.85A 5axdC-2apoB:
undetectable		 5axdC-2apoB:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3t PROTEIN
METHYLTRANSFERASE
HEMK

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		3 THR A 120
HIS A 193
LEU A 207
 SAH  A 300 (-3.3A)
None
None
 0.86A 5axdC-2b3tA:
5.9		 5axdC-2b3tA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv6 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MGRA

(Staphylococcus
aureus) 		PF01047
(MarR) 		3 THR A  37
HIS A  97
LEU A  47
 None
 0.84A 5axdC-2bv6A:
undetectable		 5axdC-2bv6A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzu FIBER PROTEIN 2

(Human
mastadenovirus
F) 		PF00541
(Adeno_knob) 		3 THR A 305
HIS A 375
LEU A 272
 None
 0.79A 5axdC-2bzuA:
undetectable		 5axdC-2bzuA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		3 THR A 254
HIS A 194
LEU A  91
 None
 0.83A 5axdC-2cb1A:
undetectable		 5axdC-2cb1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cm6 RABPHILIN-3A

(Rattus
norvegicus) 		PF00168
(C2) 		3 THR A 602
HIS A 673
LEU A 675
 None
 0.88A 5axdC-2cm6A:
undetectable		 5axdC-2cm6A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5m FLAVOREDOXIN

(Desulfovibrio
vulgaris) 		PF01613
(Flavin_Reduct) 		3 THR A  54
HIS A 124
LEU A 122
 FMN  A1001 (-4.0A)
None
None
 0.55A 5axdC-2d5mA:
undetectable		 5axdC-2d5mA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE

(Pyrococcus
horikoshii) 		PF01177
(Asp_Glu_race) 		3 THR A 180
HIS A 212
LEU A 107
 None
 0.69A 5axdC-2eq5A:
undetectable		 5axdC-2eq5A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI

(Saccharopolyspora
erythraea) 		PF08659
(KR) 		3 THR A1755
HIS A1784
LEU A1797
 None
 0.83A 5axdC-2fr1A:
5.7		 5axdC-2fr1A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493

(Streptococcus
pyogenes) 		PF02645
(DegV) 		3 THR A 267
HIS A  89
LEU A  29
 HXA  A9136 ( 4.2A)
None
None
 0.84A 5axdC-2g7zA:
2.1		 5axdC-2g7zA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grj DEPHOSPHO-COA KINASE

(Thermotoga
maritima) 		PF01121
(CoaE) 		3 THR A  98
HIS A  84
LEU A 114
 None
COD  A 201 (-3.7A)
None
 0.88A 5axdC-2grjA:
undetectable		 5axdC-2grjA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtt NUCLEOPROTEIN

(Rabies
lyssavirus) 		PF00945
(Rhabdo_ncap) 		3 THR A 252
HIS A 262
LEU A 311
 None
 0.80A 5axdC-2gttA:
undetectable		 5axdC-2gttA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi9 PLASMA SERINE
PROTEASE INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		3 THR A 141
HIS A 330
LEU A 168
 None
 0.80A 5axdC-2hi9A:
undetectable		 5axdC-2hi9A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxg L-ARABINOSE
ISOMERASE

(Escherichia
coli) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		3 THR A 451
HIS A 338
LEU A 428
 None
 0.82A 5axdC-2hxgA:
undetectable		 5axdC-2hxgA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0u ATP-DEPENDENT RNA
HELICASE DDX48

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 THR A 212
HIS A 138
LEU A 176
 None
 0.81A 5axdC-2j0uA:
2.8		 5axdC-2j0uA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsd MATRIX
METALLOPROTEINASE-20

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 THR A 203
HIS A 257
LEU A 243
 None
 0.71A 5axdC-2jsdA:
undetectable		 5axdC-2jsdA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxo HYPOTHETICAL PROTEIN
SCO4506

(Streptomyces
coelicolor) 		PF02621
(VitK2_biosynth) 		3 THR A 107
HIS A 169
LEU A 171
 None
 0.81A 5axdC-2nxoA:
undetectable		 5axdC-2nxoA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxx ECDYSONE RECEPTOR
(ECR, NRH1)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		3 THR E 365
HIS E 441
LEU E 517
 P1A  E   5 ( 3.7A)
None
None
 0.85A 5axdC-2nxxE:
undetectable		 5axdC-2nxxE:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I

(Schizosaccharomyces
pombe) 		no annotation 3 THR G 177
HIS G 289
LEU G 306
 None
 0.78A 5axdC-2ooxG:
undetectable		 5axdC-2ooxG:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9r ALPHA-2-MACROGLOBULI
N

(Homo sapiens) 		PF01835
(A2M_N) 		3 THR A 192
HIS A 133
LEU A 135
 None
 0.86A 5axdC-2p9rA:
undetectable		 5axdC-2p9rA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8q IRON-REGULATED
SURFACE DETERMINANT
E

(Staphylococcus
aureus) 		PF01497
(Peripla_BP_2) 		3 THR A 271
HIS A  92
LEU A 132
 HEM  A 300 (-4.3A)
None
None
 0.82A 5axdC-2q8qA:
undetectable		 5axdC-2q8qA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgq PROTEIN TM_1862

(Thermotoga
maritima) 		PF04055
(Radical_SAM) 		3 THR A 195
HIS A 257
LEU A 275
 None
 0.83A 5axdC-2qgqA:
2.6		 5axdC-2qgqA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD

(Lactobacillus
paracasei) 		PF04909
(Amidohydro_2) 		3 THR A 253
HIS A 227
LEU A 175
 None
ZN  A 377 (-3.1A)
None
 0.86A 5axdC-2qpxA:
undetectable		 5axdC-2qpxA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin) 		3 THR A 229
HIS A  48
LEU A 123
 None
 0.79A 5axdC-2r0lA:
undetectable		 5axdC-2r0lA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		3 THR A1317
HIS A1426
LEU A1444
 None
 0.82A 5axdC-2vdcA:
undetectable		 5axdC-2vdcA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vid SERINE PROTEASE SPLB

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		3 THR A 135
HIS A  53
LEU A 131
 None
 0.84A 5axdC-2vidA:
undetectable		 5axdC-2vidA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D

(Streptococcus
pneumoniae) 		PF03644
(Glyco_hydro_85) 		3 THR A 564
HIS A 625
LEU A 680
 None
 0.88A 5axdC-2w92A:
undetectable		 5axdC-2w92A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsk GLYCOGEN DEBRANCHING
ENZYME

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 THR A 551
HIS A 157
LEU A 538
 None
 0.66A 5axdC-2wskA:
undetectable		 5axdC-2wskA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 3 THR A  81
HIS A 635
LEU A 687
 None
 0.82A 5axdC-2yr5A:
4.2		 5axdC-2yr5A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ytu FRIEND LEUKEMIA
INTEGRATION 1
TRANSCRIPTION FACTOR

(Homo sapiens) 		PF02198
(SAM_PNT) 		3 THR A  87
HIS A  45
LEU A  75
 None
 0.79A 5axdC-2ytuA:
undetectable		 5axdC-2ytuA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zec TRYPTASE BETA 2

(Homo sapiens) 		PF00089
(Trypsin) 		3 THR A 124
HIS A 254
LEU A 109
 None
 0.80A 5axdC-2zecA:
undetectable		 5axdC-2zecA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgh GRANZYME M

(Homo sapiens) 		PF00089
(Trypsin) 		3 THR A 215
HIS A  32
LEU A 107
 None
 0.75A 5axdC-2zghA:
undetectable		 5axdC-2zghA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zk9 PROTEIN-GLUTAMINASE

(Chryseobacterium
proteolyticum) 		no annotation 3 THR X  25
HIS X  47
LEU X 163
 None
 0.78A 5axdC-2zk9X:
undetectable		 5axdC-2zk9X:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu6 EUKARYOTIC
INITIATION FACTOR
4A-I

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 THR A 207
HIS A 132
LEU A 171
 None
 0.85A 5axdC-2zu6A:
undetectable		 5axdC-2zu6A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3g LUMAZINE PROTEIN

(Photobacterium
kishitanii) 		PF00677
(Lum_binding) 		3 THR A  71
HIS A 137
LEU A  98
 None
 0.69A 5axdC-3a3gA:
undetectable		 5axdC-3a3gA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3g LUMAZINE PROTEIN

(Photobacterium
kishitanii) 		PF00677
(Lum_binding) 		3 THR A  71
HIS A 145
LEU A 169
 None
 0.62A 5axdC-3a3gA:
undetectable		 5axdC-3a3gA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a55 PROTEIN-GLUTAMINASE

(Chryseobacterium
proteolyticum) 		no annotation 3 THR A 139
HIS A 161
LEU A 277
 None
 0.79A 5axdC-3a55A:
undetectable		 5axdC-3a55A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aal PROBABLE
ENDONUCLEASE 4

(Geobacillus
kaustophilus) 		PF01261
(AP_endonuc_2) 		3 THR A 260
HIS A 248
LEU A 213
 None
 0.87A 5axdC-3aalA:
undetectable		 5axdC-3aalA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv2 MALATE SYNTHASE A

(Escherichia
coli) 		PF01274
(Malate_synthase) 		3 THR A 216
HIS A  39
LEU A 188
 None
 0.74A 5axdC-3cv2A:
undetectable		 5axdC-3cv2A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deo SIGNAL RECOGNITION
PARTICLE 43 KDA
PROTEIN

(Arabidopsis
thaliana) 		PF12796
(Ank_2) 		3 THR A  94
HIS A 199
LEU A 165
 None
 0.87A 5axdC-3deoA:
undetectable		 5axdC-3deoA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dip ENOLASE

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 THR A 275
HIS A 333
LEU A 294
 None
 0.84A 5axdC-3dipA:
2.6		 5axdC-3dipA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dip ENOLASE

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 THR A 323
HIS A 337
LEU A 300
 SIC  A 321 ( 3.8A)
None
None
 0.85A 5axdC-3dipA:
2.6		 5axdC-3dipA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		3 THR A1257
HIS A1352
LEU A1354
 None
 0.82A 5axdC-3ecqA:
undetectable		 5axdC-3ecqA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3elk PUTATIVE
TRANSCRIPTIONAL
REGULATOR TA0346

(Thermoplasma
acidophilum) 		PF03551
(PadR) 		3 THR A  40
HIS A  92
LEU A  96
 None
 0.79A 5axdC-3elkA:
undetectable		 5axdC-3elkA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exq NUDIX FAMILY
HYDROLASE

(Lactobacillus
brevis) 		PF00293
(NUDIX) 		3 THR A 137
HIS A  39
LEU A 127
 None
 0.83A 5axdC-3exqA:
undetectable		 5axdC-3exqA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		3 THR H 229
HIS H  48
LEU H 123
 None
 0.85A 5axdC-3f6uH:
undetectable		 5axdC-3f6uH:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjo NADPH-CYTOCHROME
P450 REDUCTASE

(Homo sapiens;
Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		3 THR A 231
HIS A 423
LEU A 328
 None
 0.76A 5axdC-3fjoA:
undetectable		 5axdC-3fjoA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjy PROBABLE MUTT1
PROTEIN

(Bifidobacterium
adolescentis) 		PF00293
(NUDIX)
PF00300
(His_Phos_1) 		3 THR A 173
HIS A  72
LEU A  88
 None
 0.74A 5axdC-3fjyA:
undetectable		 5axdC-3fjyA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzg 16S RRNA METHYLASE

(Escherichia
coli) 		PF07091
(FmrO) 		3 THR A 155
HIS A  83
LEU A 146
 None
SAM  A 300 (-4.4A)
None
 0.63A 5axdC-3fzgA:
4.5		 5axdC-3fzgA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1

(Schizosaccharomyces
pombe) 		PF04857
(CAF1) 		3 THR A 104
HIS A 167
LEU A 219
 None
 0.87A 5axdC-3g10A:
undetectable		 5axdC-3g10A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9k CAPSULE BIOSYNTHESIS
PROTEIN CAPD

(Bacillus
anthracis) 		no annotation 3 THR L 233
HIS L  89
LEU S 371
 None
 0.75A 5axdC-3g9kL:
undetectable		 5axdC-3g9kL:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		3 THR A 335
HIS A 464
LEU A 436
 None
 0.74A 5axdC-3gcwA:
undetectable		 5axdC-3gcwA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440

(Streptococcus
pneumoniae) 		PF03644
(Glyco_hydro_85) 		3 THR A 564
HIS A 625
LEU A 680
 None
 0.87A 5axdC-3gdbA:
undetectable		 5axdC-3gdbA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1i CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL

(Gallus gallus) 		PF00355
(Rieske)
PF02921
(UCR_TM) 		3 THR E 140
HIS E 122
LEU E 117
 None
 0.80A 5axdC-3h1iE:
undetectable		 5axdC-3h1iE:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
CYTOCHROME C1, HEME
PROTEIN

(Gallus gallus) 		PF02167
(Cytochrom_C1) 		3 THR D  55
HIS D  41
LEU D 190
 None
HEC  D 501 (-3.2A)
None
 0.78A 5axdC-3h1lD:
undetectable		 5axdC-3h1lD:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h87 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF01850
(PIN) 		3 THR A 131
HIS A  92
LEU A 100
 None
 0.59A 5axdC-3h87A:
undetectable		 5axdC-3h87A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn8 SYNAPTOTAGMIN-3

(Rattus
norvegicus) 		PF00168
(C2) 		3 THR A 491
HIS A 563
LEU A 565
 None
 0.82A 5axdC-3hn8A:
undetectable		 5axdC-3hn8A:
20.64