SIMILAR PATTERNS OF AMINO ACIDS FOR 5AXA_C_ADNC502_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbg CYANOGENIC
BETA-GLUCOSIDASE

(Trifolium
repens) 		PF00232
(Glyco_hydro_1) 		4 GLU A 397
THR A 396
HIS A 387
LEU A 279
 None
 1.05A 5axaC-1cbgA:
undetectable		 5axaC-1cbgA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f20 NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 THR A 981
THR A1019
HIS A1189
LEU A1033
 None
 1.29A 5axaC-1f20A:
2.7		 5axaC-1f20A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 THR A 455
THR A1002
HIS A 415
LEU A 410
 None
None
MGD  A1019 (-3.9A)
MGD  A1019 ( 3.4A)
 1.27A 5axaC-1kqfA:
undetectable		 5axaC-1kqfA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krh BENZOATE
1,2-DIOXYGENASE
REDUCTASE

(Acinetobacter
sp.) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 THR A  48
THR A 104
HIS A 138
LEU A 140
 None
 1.30A 5axaC-1krhA:
3.7		 5axaC-1krhA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION

(Bacillus
subtilis) 		PF01256
(Carb_kinase) 		4 THR A 204
THR A 217
HIS A 262
LEU A 259
 None
 1.09A 5axaC-1kyhA:
5.6		 5axaC-1kyhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5f SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 GLU H 157
THR H 139
HIS H  77
LEU H  24
 None
 1.08A 5axaC-1o5fH:
undetectable		 5axaC-1o5fH:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 37 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 THR B 295
THR B 269
HIS B 232
LEU B 256
 None
 1.28A 5axaC-1sxjB:
undetectable		 5axaC-1sxjB:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0p INTEGRIN ALPHA-L

(Homo sapiens) 		PF00092
(VWA) 		4 GLU A 180
THR A 206
HIS A 264
LEU A 142
 None
MG  A 901 (-2.7A)
None
None
 1.30A 5axaC-1t0pA:
2.6		 5axaC-1t0pA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdq TENASCIN-R

(Rattus
norvegicus) 		PF00041
(fn3) 		4 GLU A 113
THR A 149
HIS A 137
LEU A 153
 None
 1.22A 5axaC-1tdqA:
undetectable		 5axaC-1tdqA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tll NITRIC-OXIDE
SYNTHASE, BRAIN

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 THR A 981
THR A1019
HIS A1189
LEU A1033
 None
 1.30A 5axaC-1tllA:
3.5		 5axaC-1tllA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tpy METHOXY MYCOLIC ACID
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		4 GLU A 140
THR A 170
HIS A 155
LEU A 164
 CO3  A 902 ( 3.3A)
None
None
None
 1.17A 5axaC-1tpyA:
3.6		 5axaC-1tpyA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v72 ALDOLASE

(Pseudomonas
putida) 		PF01212
(Beta_elim_lyase) 		4 GLU A 132
THR A 130
THR A  80
LEU A 111
 None
 1.01A 5axaC-1v72A:
undetectable		 5axaC-1v72A:
22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v8b ADENOSYLHOMOCYSTEINA
SE

(Plasmodium
falciparum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 GLU A  58
THR A 201
HIS A 345
LEU A 389
 ADN  A 502 (-3.6A)
NAD  A 501 ( 2.8A)
NAD  A 501 (-4.8A)
NAD  A 501 ( 3.8A)
 0.23A 5axaC-1v8bA:
55.5		 5axaC-1v8bA:
53.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcm DNA-DIRECTED RNA
POLYMERASE II 32 KDA
POLYPEPTIDE

(Saccharomyces
cerevisiae) 		PF03874
(RNA_pol_Rpb4) 		4 GLU D 208
THR D 170
HIS D 173
LEU D 198
 None
 1.29A 5axaC-1wcmD:
undetectable		 5axaC-1wcmD:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 GLU A 694
THR A 695
THR A 633
LEU A 639
 None
 1.30A 5axaC-1z1wA:
undetectable		 5axaC-1z1wA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo sapiens) 		PF00398
(RrnaAD) 		4 THR A 237
THR A 283
HIS A 303
LEU A 226
 None
 1.31A 5axaC-1zq9A:
3.2		 5axaC-1zq9A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY

(Bacteroides
thetaiotaomicron) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 GLU A  75
THR A 103
HIS A 106
LEU A  55
 None
 1.13A 5axaC-1zybA:
undetectable		 5axaC-1zybA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4e CORONIN-1A

(Mus musculus) 		PF00400
(WD40)
PF08953
(DUF1899)
PF16300
(WD40_4) 		4 GLU A 296
THR A 279
HIS A 225
LEU A 284
 None
 1.15A 5axaC-2b4eA:
undetectable		 5axaC-2b4eA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like) 		4 GLU A 286
THR A 292
THR A 245
HIS A 235
 None
None
None
MG  A 401 (-3.2A)
 1.31A 5axaC-2cw6A:
undetectable		 5axaC-2cw6A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpg GLUCOSE 6-PHOSPHATE
DEHYDROGENASE

(Leuconostoc
mesenteroides) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 THR A 422
THR A   9
HIS A  84
LEU A 130
 None
 1.21A 5axaC-2dpgA:
4.6		 5axaC-2dpgA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e80 CYTOCHROME C-552

(Wolinella
succinogenes) 		PF02335
(Cytochrom_C552) 		4 GLU A 371
THR A 270
HIS A 385
LEU A 428
 None
 1.23A 5axaC-2e80A:
undetectable		 5axaC-2e80A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ed6 25KDA STRUCTURAL
PROTEIN VP25

(White spot
syndrome virus) 		PF12175
(WSS_VP) 		4 GLU A 165
THR A 128
THR A  46
HIS A  40
 None
 1.24A 5axaC-2ed6A:
undetectable		 5axaC-2ed6A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gca FOLYLPOLYGLUTAMATE
SYNTHASE

(Lactobacillus
casei) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 GLU A 165
THR A 164
HIS A 296
LEU A 256
 None
 1.15A 5axaC-2gcaA:
2.4		 5axaC-2gcaA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3

(Arabidopsis
thaliana) 		PF00753
(Lactamase_B) 		4 GLU A 121
THR A 137
THR A  71
HIS A 128
 None
None
None
FE2  A 300 (-3.4A)
 1.19A 5axaC-2gcuA:
undetectable		 5axaC-2gcuA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hek HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF01966
(HD) 		4 GLU A 117
THR A 116
HIS A  54
LEU A  31
 None
None
ZN  A 602 ( 3.4A)
None
 1.30A 5axaC-2hekA:
undetectable		 5axaC-2hekA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6i HD DOMAIN PROTEIN

(Enterococcus
faecalis) 		PF01966
(HD) 		4 GLU A 143
THR A 142
HIS A  66
LEU A  43
 None
None
ZN  A 501 (-3.4A)
None
 1.12A 5axaC-2o6iA:
undetectable		 5axaC-2o6iA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqd PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Staphylococcus
aureus) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		4 GLU A 511
THR A 512
THR A 455
LEU A 522
 None
 1.30A 5axaC-2wqdA:
undetectable		 5axaC-2wqdA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsi DELLA PROTEIN GAI
PROBABLE GIBBERELLIN
RECEPTOR GID1L1

(Arabidopsis
thaliana) 		PF07859
(Abhydrolase_3)
PF12041
(DELLA) 		4 GLU B  54
THR B  72
HIS A  44
LEU A  34
 None
 1.28A 5axaC-2zsiB:
undetectable		 5axaC-2zsiB:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 4 GLU A 435
THR A 437
THR A 406
LEU A 374
 None
 1.04A 5axaC-3a0fA:
undetectable		 5axaC-3a0fA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1i AMIDASE

(Rhodococcus sp.
N-771) 		PF01425
(Amidase) 		4 THR A 424
THR A 234
HIS A 238
LEU A 491
 None
 1.05A 5axaC-3a1iA:
undetectable		 5axaC-3a1iA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez1 AMINOTRANSFERASE
MOCR FAMILY

(Deinococcus
geothermalis) 		PF12897
(Aminotran_MocR) 		4 GLU A 323
THR A 393
HIS A 218
LEU A 220
 None
 1.19A 5axaC-3ez1A:
3.8		 5axaC-3ez1A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Clostridioides
difficile) 		PF01380
(SIS) 		4 GLU A 209
THR A 258
THR A 222
HIS A 215
 None
 1.26A 5axaC-3g68A:
3.0		 5axaC-3g68A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Giardia
intestinalis) 		PF01116
(F_bP_aldolase) 		4 GLU A 163
THR A 203
THR A 118
HIS A 109
 None
 1.19A 5axaC-3gayA:
undetectable		 5axaC-3gayA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdy UDP-GALACTOPYRANOSE
MUTASE

(Deinococcus
radiodurans) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 GLU A 103
THR A 102
THR A 313
HIS A 317
 None
 1.22A 5axaC-3hdyA:
undetectable		 5axaC-3hdyA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k17 LIN0012 PROTEIN

(Listeria
innocua) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 GLU A  46
THR A  44
THR A  80
HIS A  76
 None
 1.19A 5axaC-3k17A:
undetectable		 5axaC-3k17A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvg CLATHRIN HEAVY CHAIN
1

(Bos taurus) 		PF00637
(Clathrin) 		4 GLU A1369
THR A1377
HIS A1356
LEU A1349
 None
 1.19A 5axaC-3lvgA:
undetectable		 5axaC-3lvgA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3md0 ARGININE/ORNITHINE
TRANSPORT SYSTEM
ATPASE

(Mycobacterium
tuberculosis) 		PF03308
(ArgK) 		4 GLU A 157
THR A 158
THR A 174
LEU A 253
 None
 1.30A 5axaC-3md0A:
undetectable		 5axaC-3md0A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN

(Triatoma virus) 		PF00073
(Rhv) 		4 GLU C  57
THR C 111
HIS C  87
LEU C 121
 None
 0.93A 5axaC-3napC:
undetectable		 5axaC-3napC:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd1 PRECORRIN-6A
SYNTHASE/COBF
PROTEIN

(Rhodobacter
capsulatus) 		PF00590
(TP_methylase) 		4 GLU A  90
THR A  91
THR A 121
LEU A   4
 None
 1.26A 5axaC-3nd1A:
undetectable		 5axaC-3nd1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		4 GLU A 198
THR A 195
THR A 248
LEU A 169
 None
 0.94A 5axaC-3nowA:
undetectable		 5axaC-3nowA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvx PROTEIN A39

(Vaccinia virus) 		PF01403
(Sema) 		4 THR A 262
THR A 233
HIS A 230
LEU A 173
 None
 1.31A 5axaC-3nvxA:
undetectable		 5axaC-3nvxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT BETA

(Desulfovibrio
gigas) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 GLU B 109
THR B 110
HIS B  44
LEU B  47
 None
None
SRM  B 581 (-3.8A)
None
 0.99A 5axaC-3or2B:
undetectable		 5axaC-3or2B:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pja TRANSLIN

(Homo sapiens) 		PF01997
(Translin) 		4 GLU A 111
THR A 110
HIS A  64
LEU A  42
 None
 1.28A 5axaC-3pjaA:
undetectable		 5axaC-3pjaA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl0 UNCHARACTERIZED
PROTEIN

(Methylibium
petroleiphilum) 		PF10014
(2OG-Fe_Oxy_2) 		4 GLU A 219
THR A 239
HIS A 236
LEU A 223
 None
 0.97A 5axaC-3pl0A:
undetectable		 5axaC-3pl0A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl0 UNCHARACTERIZED
PROTEIN

(Methylibium
petroleiphilum) 		PF10014
(2OG-Fe_Oxy_2) 		4 THR A  33
THR A  13
HIS A   2
LEU A   7
 None
 1.31A 5axaC-3pl0A:
undetectable		 5axaC-3pl0A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q94 FRUCTOSE-BISPHOSPHAT
E ALDOLASE, CLASS II

(Bacillus
anthracis) 		PF01116
(F_bP_aldolase) 		4 GLU A 166
THR A 202
THR A 120
HIS A 111
 None
None
None
ZN  A 302 (-3.5A)
 1.24A 5axaC-3q94A:
undetectable		 5axaC-3q94A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxb PUTATIVE XYLOSE
ISOMERASE

(Rhodospirillum
rubrum) 		PF01261
(AP_endonuc_2) 		4 GLU A 186
THR A 185
THR A 112
HIS A  96
 None
 1.22A 5axaC-3qxbA:
undetectable		 5axaC-3qxbA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd8 FUMARATE HYDRATASE
CLASS II

(Mycolicibacterium
smegmatis) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 GLU A 369
THR A 372
THR A 145
LEU A  44
 None
 1.29A 5axaC-3rd8A:
undetectable		 5axaC-3rd8A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrp PROBABLE FUMARATE
HYDRATASE FUM

(Mycobacteroides
abscessus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 GLU A 370
THR A 373
THR A 146
LEU A  43
 None
 1.28A 5axaC-3rrpA:
undetectable		 5axaC-3rrpA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 GLU A 403
THR A 393
HIS A 427
LEU A 429
 None
 1.25A 5axaC-3s29A:
undetectable		 5axaC-3s29A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		4 GLU A 572
THR A 573
HIS A 881
LEU A 550
 None
None
None
GBL  A1254 ( 4.2A)
 1.27A 5axaC-3sfzA:
undetectable		 5axaC-3sfzA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc1 OCTAPRENYL
PYROPHOSPHATE
SYNTHASE

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		4 GLU A 271
THR A 272
THR A 225
LEU A 244
 None
 1.29A 5axaC-3tc1A:
undetectable		 5axaC-3tc1A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrk CARBONYL SULFIDE
HYDROLASE

(Thiobacillus
thioparus) 		PF00484
(Pro_CA) 		4 GLU A  61
THR A  59
HIS A  97
LEU A  54
 None
None
ZN  A 301 (-3.2A)
None
 1.01A 5axaC-3vrkA:
2.0		 5axaC-3vrkA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amg SNOGD

(Streptomyces
nogalater) 		PF06722
(DUF1205) 		4 GLU A 144
THR A 125
HIS A  41
LEU A 121
 None
 1.20A 5axaC-4amgA:
4.7		 5axaC-4amgA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115

(Bacteroides
ovatus) 		PF15979
(Glyco_hydro_115) 		4 GLU A 320
THR A 319
THR A 324
HIS A 275
 None
 0.89A 5axaC-4c90A:
undetectable		 5axaC-4c90A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLU A 215
THR A 212
THR A 122
LEU A 154
 None
 1.25A 5axaC-4fr4A:
undetectable		 5axaC-4fr4A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 GLU A 550
THR A 549
HIS A 701
LEU A 698
 None
 1.05A 5axaC-4gzuA:
undetectable		 5axaC-4gzuA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h63 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomyces
pombe) 		PF10156
(Med17) 		4 GLU Q 348
THR Q 349
HIS Q 400
LEU Q 314
 None
 1.24A 5axaC-4h63Q:
undetectable		 5axaC-4h63Q:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLU A 810
THR A 811
HIS A 842
LEU A 662
 None
 1.18A 5axaC-4iigA:
3.3		 5axaC-4iigA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilk STARVATION SENSING
PROTEIN RSPB

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A 336
THR A 308
HIS A 329
LEU A 322
 None
 1.11A 5axaC-4ilkA:
4.5		 5axaC-4ilkA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbd PROLINE RACEMASE

(Pseudomonas
putida) 		PF05544
(Pro_racemase) 		4 GLU A 180
THR A 183
THR A 265
HIS A  10
 None
 1.14A 5axaC-4jbdA:
undetectable		 5axaC-4jbdA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		4 GLU A 146
THR A 148
HIS A 164
LEU A 170
 None
None
None
EPE  A 603 ( 4.0A)
 1.22A 5axaC-4je5A:
2.4		 5axaC-4je5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4x AMPHI

(Streptomyces
nodosus) 		PF08659
(KR) 		4 GLU A 331
THR A 330
HIS A 364
LEU A 281
 None
 1.21A 5axaC-4l4xA:
5.1		 5axaC-4l4xA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE

(Burkholderia
cenocepacia) 		PF01041
(DegT_DnrJ_EryC1) 		4 GLU A  66
THR A  97
THR A  82
HIS A 328
 None
 1.30A 5axaC-4lc3A:
undetectable		 5axaC-4lc3A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 GLU A 371
THR A 440
THR A 361
HIS A 427
 None
 1.30A 5axaC-4mvfA:
undetectable		 5axaC-4mvfA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN

(Bordetella
bronchiseptica) 		PF03480
(DctP) 		4 GLU A 172
THR A 171
THR A 101
LEU A 237
 None
PAF  A 401 (-4.5A)
None
None
 1.10A 5axaC-4nq8A:
undetectable		 5axaC-4nq8A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nrh COPN

(Chlamydia
pneumoniae) 		PF07201
(HrpJ) 		4 THR A 275
THR A 267
HIS A 215
LEU A 224
 None
 1.27A 5axaC-4nrhA:
undetectable		 5axaC-4nrhA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8s PUTATIVE

(Helicobacter
pylori) 		PF08843
(AbiEii) 		4 GLU A  40
THR A  41
THR A 109
HIS A  84
 None
 1.27A 5axaC-4o8sA:
undetectable		 5axaC-4o8sA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdi UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE

(Acinetobacter
baumannii) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 GLU A 130
THR A 126
THR A 342
HIS A 454
 None
MG  A 503 ( 3.6A)
None
None
 1.15A 5axaC-4qdiA:
3.3		 5axaC-4qdiA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uon CAPSID PROTEASE

(Aura virus) 		PF00944
(Peptidase_S3) 		4 GLU A 136
THR A 118
HIS A 195
LEU A 223
 None
 1.26A 5axaC-4uonA:
undetectable		 5axaC-4uonA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4up5 PYGOPUS HOMOLOG 2,
B-CELL CLL/LYMPHOMA
9-LIKE PROTEIN

(Homo sapiens) 		PF00628
(PHD) 		4 GLU A 372
THR A 371
THR A 362
LEU A1251
 None
 1.07A 5axaC-4up5A:
undetectable		 5axaC-4up5A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wiw GLYCOSIDE HYDROLASE
FAMILY 18

(Desulfitobacterium
hafniense) 		PF00704
(Glyco_hydro_18) 		4 GLU A 460
THR A 461
HIS A 522
LEU A 527
 CA  A 704 (-2.8A)
None
None
None
 1.15A 5axaC-4wiwA:
undetectable		 5axaC-4wiwA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xni DI-OR TRIPEPTIDE:H+
SYMPORTER

(Streptococcus
thermophilus) 		PF00854
(PTR2) 		4 GLU A  22
THR A  21
THR A 135
HIS A 204
 None
 1.17A 5axaC-4xniA:
undetectable		 5axaC-4xniA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yco TRNA-DIHYDROURIDINE
SYNTHASE C

(Escherichia
coli) 		PF01207
(Dus) 		4 GLU A  18
THR A  21
THR A  31
LEU A  53
 None
 1.21A 5axaC-4ycoA:
undetectable		 5axaC-4ycoA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3

(Bifidobacterium
adolescentis) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 GLU A 315
THR A 316
THR A 446
LEU A 292
 None
 1.30A 5axaC-4ye5A:
undetectable		 5axaC-4ye5A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aga DNA POLYMERASE THETA

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLU A 332
THR A 333
THR A 488
LEU A 293
 None
 1.20A 5axaC-5agaA:
undetectable		 5axaC-5agaA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		4 GLU A 351
THR A 260
HIS A 491
LEU A 325
 None
 1.30A 5axaC-5btrA:
3.9		 5axaC-5btrA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtb CG3822

(Drosophila
melanogaster) 		PF10613
(Lig_chan-Glu_bd) 		4 GLU A 202
THR A 199
HIS A  45
LEU A 253
 None
 1.11A 5axaC-5dtbA:
undetectable		 5axaC-5dtbA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN ALPHA-L

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 GLU A 180
THR A 206
HIS A 264
LEU A 142
 None
MG  A2001 (-4.3A)
None
None
 1.27A 5axaC-5e6sA:
3.5		 5axaC-5e6sA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE

(Microbispora
corallina) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		4 GLU A 482
THR A 484
THR A 686
LEU A 394
 None
 1.25A 5axaC-5ehkA:
undetectable		 5axaC-5ehkA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fa1 PUTATIVE N-ACETYL
GLUCOSAMINYL
TRANSFERASE

(Raoultella
terrigena) 		PF05159
(Capsule_synth) 		4 GLU A 355
THR A 133
HIS A 156
LEU A 173
 None
 1.09A 5axaC-5fa1A:
undetectable		 5axaC-5fa1A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1k GEM-ASSOCIATED
PROTEIN 5

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 GLU A 283
THR A 288
HIS A 290
LEU A 308
 None
 1.25A 5axaC-5h1kA:
undetectable		 5axaC-5h1kA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1l TOXR-ACTIVATED GENE
(TAGE)

(Helicobacter
pylori) 		PF01551
(Peptidase_M23) 		4 GLU A 146
THR A 268
HIS A 167
LEU A 174
 None
 1.28A 5axaC-5j1lA:
undetectable		 5axaC-5j1lA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomyces
pombe) 		PF10156
(Med17) 		4 GLU W 348
THR W 349
HIS W 400
LEU W 314
 None
 1.13A 5axaC-5n9jW:
undetectable		 5axaC-5n9jW:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 4 GLU B 638
THR B 635
HIS B 818
LEU B 894
 None
 1.31A 5axaC-5nd1B:
undetectable		 5axaC-5nd1B:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5net O1 MANISA VP3

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		4 GLU 3  49
THR 3  89
HIS 3  85
LEU 3 107
 None
 1.27A 5axaC-5net3:
undetectable		 5axaC-5net3:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE

(Enterobacter
cloacae) 		PF01977
(UbiD) 		4 GLU A 326
THR A 319
THR A 141
HIS A 285
 None
 1.29A 5axaC-5ny5A:
undetectable		 5axaC-5ny5A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Pseudomonas
syringae) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 THR A 103
THR A  66
HIS A  31
LEU A  83
 None
NAP  A 301 (-4.3A)
None
None
 1.09A 5axaC-5u5gA:
9.7		 5axaC-5u5gA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ud0 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Helicobacter
pylori) 		no annotation 4 GLU A 161
THR A 203
THR A 117
HIS A 107
 None
 1.30A 5axaC-5ud0A:
undetectable		 5axaC-5ud0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ud0 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Helicobacter
pylori) 		no annotation 4 GLU A 161
THR A 203
THR A 117
HIS A 108
 None
 1.12A 5axaC-5ud0A:
undetectable		 5axaC-5ud0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Campylobacter
jejuni) 		PF00275
(EPSP_synthase) 		4 GLU A 235
THR A 238
HIS A 390
LEU A   4
 None
 1.27A 5axaC-5ujsA:
undetectable		 5axaC-5ujsA:
23.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 GLU A  57
THR A  58
THR A 212
HIS A 356
LEU A 401
 SAH  A 502 (-3.7A)
SAH  A 502 (-4.2A)
NAD  A 501 ( 4.1A)
NAD  A 501 ( 4.4A)
NAD  A 501 (-4.1A)
 0.62A 5axaC-5utuA:
53.5		 5axaC-5utuA:
48.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE

(Naegleria
fowleri) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 GLU A  63
THR A  64
THR A 198
HIS A 342
LEU A 386
 ADN  A 502 (-3.6A)
ADN  A 502 (-4.4A)
NAD  A 501 ( 2.9A)
NAD  A 501 ( 4.9A)
NAD  A 501 (-3.9A)
 0.18A 5axaC-5v96A:
57.9		 5axaC-5v96A:
57.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 THR A 652
THR A 708
HIS A 710
LEU A 719
 None
 1.23A 5axaC-5vniA:
undetectable		 5axaC-5vniA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y79 PUTATIVE HEXOSE
PHOSPHATE
TRANSLOCATOR

(Galdieria
sulphuraria) 		PF03151
(TPT) 		4 GLU A 207
THR A 360
THR A 230
HIS A 224
 None
None
OLC  A 511 ( 4.8A)
None
 1.20A 5axaC-5y79A:
undetectable		 5axaC-5y79A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2w PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE FAMILY
PROTEIN

(Campylobacter
jejuni) 		no annotation 4 GLU A 176
THR A 151
HIS A 199
LEU A 136
 None
None
AG2  A 401 (-3.7A)
None
 1.28A 5axaC-6b2wA:
undetectable		 5axaC-6b2wA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		no annotation 4 GLU G 106
THR G  89
THR A 541
LEU A 421
 None
 1.28A 5axaC-6c66G:
undetectable		 5axaC-6c66G:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER

(Enterococcus
casseliflavus) 		no annotation 4 GLU A 318
THR A 306
THR A 282
LEU A  39
 None
 1.27A 5axaC-6d0nA:
undetectable		 5axaC-6d0nA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE

(Mycobacterium
tuberculosis) 		no annotation 4 GLU C 277
THR C 276
HIS C 109
LEU C 221
 None
None
MPD  C 302 (-4.3A)
None
 1.25A 5axaC-6eicC:
3.0		 5axaC-6eicC:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fpe TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE
TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAB

(Thermotoga
maritima) 		no annotation 4 GLU B   7
THR B  13
HIS A  33
LEU B  87
 None
 1.28A 5axaC-6fpeB:
undetectable		 5axaC-6fpeB:
12.26