SIMILAR PATTERNS OF AMINO ACIDS FOR 5AOX_F_ACTF1001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a80 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE A

(Corynebacterium
sp.) 		PF00248
(Aldo_ket_red) 		3 TYR A 105
THR A  73
THR A 133
 None
 0.82A 5aoxE-1a80A:
0.0		 5aoxE-1a80A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1air PECTATE LYASE C

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		3 TYR A   7
THR A 179
THR A 177
 None
 0.81A 5aoxE-1airA:
undetectable		 5aoxE-1airA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bry BRYODIN I

(Bryonia dioica) 		PF00161
(RIP) 		3 TYR Y 141
THR Y 143
THR Y 137
 None
 0.66A 5aoxE-1bryY:
0.0		 5aoxE-1bryY:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6f PROLACTIN RECEPTOR

(Rattus
norvegicus) 		PF00041
(fn3)
PF09067
(EpoR_lig-bind) 		3 TYR B 144
THR B 182
THR B 161
 None
 0.80A 5aoxE-1f6fB:
0.7		 5aoxE-1f6fB:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz4 NAD-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		3 TYR A 273
THR A 250
THR A 275
 None
 0.82A 5aoxE-1gz4A:
0.0		 5aoxE-1gz4A:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7k UBIQUITIN-CONJUGATIN
G ENZYME E2 H10

(Homo sapiens) 		PF00179
(UQ_con) 		3 TYR A  79
THR A  65
THR A 100
 None
 0.75A 5aoxE-1i7kA:
0.3		 5aoxE-1i7kA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 TYR A2691
THR A2628
THR A2688
 None
 0.78A 5aoxE-1js8A:
0.0		 5aoxE-1js8A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogq POLYGALACTURONASE
INHIBITING PROTEIN

(Phaseolus
vulgaris) 		PF08263
(LRRNT_2) 		3 TYR A 107
THR A 155
THR A 109
 None
 0.82A 5aoxE-1ogqA:
undetectable		 5aoxE-1ogqA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtk COMPLEMENT FACTOR B

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		3 TYR A 465
THR A 566
THR A 463
 None
IOD  A 741 ( 4.5A)
None
 0.76A 5aoxE-1rtkA:
0.0		 5aoxE-1rtkA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv TRANSFERRIN RECEPTOR
PROTEIN 1

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		3 TYR A 565
THR A 568
THR A 572
 None
 0.71A 5aoxE-1suvA:
undetectable		 5aoxE-1suvA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2k OSTEOCLAST
STIMULATING FACTOR 1

(Homo sapiens) 		PF00018
(SH3_1) 		3 TYR A  33
THR A  35
THR A  46
 None
 0.66A 5aoxE-1x2kA:
undetectable		 5aoxE-1x2kA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yc9 MULTIDRUG RESISTANCE
PROTEIN

(Vibrio cholerae) 		PF02321
(OEP) 		3 TYR A 143
THR A 145
THR A 123
 None
 0.68A 5aoxE-1yc9A:
undetectable		 5aoxE-1yc9A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zg2 HYPOTHETICAL UPF0213
PROTEIN BH0048

(Bacillus
halodurans) 		PF01541
(GIY-YIG) 		3 TYR A   9
THR A  55
THR A  25
 None
 0.74A 5aoxE-1zg2A:
undetectable		 5aoxE-1zg2A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgd CHALCONE REDUCTASE

(Medicago sativa) 		PF00248
(Aldo_ket_red) 		3 TYR A 117
THR A  85
THR A 160
 None
 0.77A 5aoxE-1zgdA:
undetectable		 5aoxE-1zgdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvy IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN

(Camelus
dromedarius) 		PF07686
(V-set) 		3 TYR A  33
THR A  35
THR A  99
 None
 0.68A 5aoxE-1zvyA:
undetectable		 5aoxE-1zvyA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A 155
THR A 151
THR A 158
 None
 0.80A 5aoxE-2c47A:
undetectable		 5aoxE-2c47A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4x ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF00801
(PKD) 		3 TYR A  40
THR A  54
THR A  52
 None
 0.81A 5aoxE-2c4xA:
undetectable		 5aoxE-2c4xA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d42 NON-TOXIC CRYSTAL
PROTEIN

(Bacillus
thuringiensis) 		PF03318
(ETX_MTX2) 		3 TYR A 222
THR A 224
THR A 213
 None
 0.81A 5aoxE-2d42A:
undetectable		 5aoxE-2d42A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e2c UBIQUITIN
CONJUGATING ENZYME

(Spisula
solidissima) 		PF00179
(UQ_con) 		3 TYR A  79
THR A  65
THR A 100
 None
 0.82A 5aoxE-2e2cA:
undetectable		 5aoxE-2e2cA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8t ARGONAUTE PROTEIN

(Aquifex
aeolicus) 		PF02171
(Piwi) 		3 TYR A 532
THR A 534
THR A 519
 None
 0.36A 5aoxE-2f8tA:
1.4		 5aoxE-2f8tA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbl HYPOTHETICAL PROTEIN
NE1496

(Nitrosomonas
europaea) 		PF01928
(CYTH) 		3 TYR A  27
THR A  77
THR A  29
 None
 0.55A 5aoxE-2fblA:
undetectable		 5aoxE-2fblA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8q RED FLUORESCENT
PROTEIN DRFP583

(Discosoma sp.) 		PF01353
(GFP) 		3 TYR A 214
THR A 202
THR A  43
 None
 0.83A 5aoxE-2h8qA:
undetectable		 5aoxE-2h8qA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyk BETA-1,3-GLUCANASE

(Nocardiopsis
sp. F96) 		PF00722
(Glyco_hydro_16) 		3 TYR A 192
THR A 181
THR A 193
 None
None
SO4  A 251 ( 2.7A)
 0.81A 5aoxE-2hykA:
undetectable		 5aoxE-2hykA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Porphyromonas
gingivalis) 		PF04095
(NAPRTase) 		3 TYR A  13
THR A 210
THR A  17
 None
 0.83A 5aoxE-2im5A:
undetectable		 5aoxE-2im5A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipf (3(17)ALPHA-HYDROXYS
TEROID
DEHYDROGENASE)

(Mus musculus) 		PF00248
(Aldo_ket_red) 		3 TYR A 114
THR A  82
THR A 160
 None
 0.82A 5aoxE-2ipfA:
undetectable		 5aoxE-2ipfA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 HYPOTHETICAL PROTEIN
YPL007C

(Saccharomyces
cerevisiae) 		PF12660
(zf-TFIIIC) 		3 TYR A  30
THR A  32
THR A  22
 None
 0.81A 5aoxE-2j04A:
undetectable		 5aoxE-2j04A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mri 26S PROTEASOME
REGULATORY SUBUNIT
RPN9

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		3 TYR A 195
THR A 191
THR A 198
 None
 0.80A 5aoxE-2mriA:
undetectable		 5aoxE-2mriA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkd SLAM FAMILY MEMBER 5

(Homo sapiens) 		no annotation 3 TYR A  42
THR A  44
THR A  55
 None
 0.66A 5aoxE-2pkdA:
undetectable		 5aoxE-2pkdA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0v UBIQUITIN-CONJUGATIN
G ENZYME E2,
PUTATIVE

(Plasmodium
falciparum) 		PF00179
(UQ_con) 		3 TYR A  74
THR A  60
THR A  95
 None
 0.76A 5aoxE-2q0vA:
undetectable		 5aoxE-2q0vA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vha PERIPLASMIC BINDING
TRANSPORT PROTEIN

(Shigella
flexneri) 		PF00497
(SBP_bac_3) 		3 TYR A 211
THR A 106
THR A  92
 GLU  A1280 (-4.7A)
None
GLU  A1280 (-4.0A)
 0.74A 5aoxE-2vhaA:
undetectable		 5aoxE-2vhaA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2r MATRIX PROTEIN

(Vesicular
stomatitis
virus) 		PF06326
(Vesiculo_matrix) 		3 TYR A 132
THR A 119
THR A  71
 None
 0.82A 5aoxE-2w2rA:
undetectable		 5aoxE-2w2rA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w38 SIALIDASE

(Pseudomonas
aeruginosa) 		PF13088
(BNR_2) 		3 TYR A  20
THR A 320
THR A  43
 GOL  A1439 ( 3.5A)
GOL  A1442 ( 4.7A)
GOL  A1442 (-4.2A)
 0.83A 5aoxE-2w38A:
2.5		 5aoxE-2w38A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk8 CAI-1 AUTOINDUCER
SYNTHASE

(Vibrio cholerae) 		PF00155
(Aminotran_1_2) 		3 TYR A 176
THR A 178
THR A 181
 None
 0.60A 5aoxE-2wk8A:
undetectable		 5aoxE-2wk8A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wlp COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		3 TYR A 251
THR A 253
THR A 126
 None
 0.81A 5aoxE-2wlpA:
undetectable		 5aoxE-2wlpA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adj F21M12.9 PROTEIN

(Arabidopsis
thaliana) 		PF00035
(dsrm) 		3 TYR A 145
THR A 137
THR A 163
 None
 0.74A 5aoxE-3adjA:
undetectable		 5aoxE-3adjA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh3 ACETOACETATE
DECARBOXYLASE

(Chromobacterium
violaceum) 		PF06314
(ADC) 		3 TYR A  25
THR A 233
THR A  70
 None
 0.70A 5aoxE-3bh3A:
undetectable		 5aoxE-3bh3A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8w ACETOACETATE
DECARBOXYLASE ADC

(Legionella
pneumophila) 		PF06314
(ADC) 		3 TYR A  34
THR A 242
THR A  79
 None
 0.69A 5aoxE-3c8wA:
undetectable		 5aoxE-3c8wA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czm L-LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 TYR A 205
THR A 207
THR A 190
 None
 0.69A 5aoxE-3czmA:
undetectable		 5aoxE-3czmA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		3 TYR A 497
THR A 527
THR A 471
 None
 0.83A 5aoxE-3ecqA:
undetectable		 5aoxE-3ecqA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3er6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR PROTEIN

(Vibrio
parahaemolyticus) 		PF01965
(DJ-1_PfpI) 		3 TYR A  20
THR A 116
THR A  17
 None
 0.82A 5aoxE-3er6A:
undetectable		 5aoxE-3er6A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi9 MALATE DEHYDROGENASE

(Porphyromonas
gingivalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 TYR A  38
THR A  10
THR A  65
 None
 0.58A 5aoxE-3fi9A:
undetectable		 5aoxE-3fi9A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fl7 EPHRIN RECEPTOR

(Homo sapiens) 		PF00041
(fn3)
PF01404
(Ephrin_lbd) 		3 TYR A 334
THR A 336
THR A 349
 None
 0.64A 5aoxE-3fl7A:
undetectable		 5aoxE-3fl7A:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fww BIFUNCTIONAL PROTEIN
GLMU

(Yersinia pestis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		3 TYR A 197
THR A  82
THR A 199
 None
 0.77A 5aoxE-3fwwA:
undetectable		 5aoxE-3fwwA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd8 XYLANASE INHIBITOR

(Triticum
aestivum) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		3 TYR A 285
THR A 327
THR A 289
 None
 0.75A 5aoxE-3hd8A:
undetectable		 5aoxE-3hd8A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3it8 2L PROTEIN

(Tanapox virus) 		no annotation 3 TYR D  98
THR D   2
THR D 100
 None
 0.72A 5aoxE-3it8D:
undetectable		 5aoxE-3it8D:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8i 30KLP

(Treponema
pallidum) 		no annotation 3 TYR A 217
THR A 219
THR A 228
 None
 0.57A 5aoxE-3k8iA:
undetectable		 5aoxE-3k8iA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kny HYPOTHETICAL PROTEIN
BT_3535

(Bacteroides
thetaiotaomicron) 		no annotation 3 TYR A 141
THR A 143
THR A 119
 None
 0.77A 5aoxE-3knyA:
undetectable		 5aoxE-3knyA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzw CYTOSOL
AMINOPEPTIDASE

(Staphylococcus
aureus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 TYR A  58
THR A  60
THR A  73
 None
 0.73A 5aoxE-3kzwA:
undetectable		 5aoxE-3kzwA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1l 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		3 TYR A 360
THR A 358
THR A 363
 None
 0.78A 5aoxE-3m1lA:
undetectable		 5aoxE-3m1lA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msw UNCHARACTERIZED
PROTEIN

(Bacteroides
fragilis) 		PF12930
(DUF3836) 		3 TYR A 127
THR A 129
THR A 105
 None
 0.78A 5aoxE-3mswA:
undetectable		 5aoxE-3mswA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtx PROTEIN MD-1

(Gallus gallus) 		PF02221
(E1_DerP2_DerF2) 		3 TYR A  36
THR A  24
THR A 153
 None
 0.83A 5aoxE-3mtxA:
undetectable		 5aoxE-3mtxA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx0 EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF00041
(fn3)
PF01404
(Ephrin_lbd) 		3 TYR A 334
THR A 336
THR A 349
 None
 0.73A 5aoxE-3mx0A:
undetectable		 5aoxE-3mx0A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om9 LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 TYR A 205
THR A 207
THR A 190
 None
 0.64A 5aoxE-3om9A:
undetectable		 5aoxE-3om9A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opu SPAP

(Streptococcus
mutans) 		PF16364
(Antigen_C) 		3 TYR A1382
THR A1474
THR A1434
 None
 0.75A 5aoxE-3opuA:
undetectable		 5aoxE-3opuA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orq N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
SYNTHETASE

(Staphylococcus
aureus) 		PF02222
(ATP-grasp)
PF02826
(2-Hacid_dh_C) 		3 TYR A 278
THR A 353
THR A 222
 None
 0.82A 5aoxE-3orqA:
undetectable		 5aoxE-3orqA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sy9 HISTIDINE PORIN OPDC

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		3 TYR A 243
THR A 245
THR A 260
 None
 0.38A 5aoxE-3sy9A:
undetectable		 5aoxE-3sy9A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syb GLYCINE-GLUTAMATE
DIPEPTIDE PORIN OPDP

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		3 TYR A 280
THR A 282
THR A 297
 None
 0.46A 5aoxE-3sybA:
undetectable		 5aoxE-3sybA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE

(Rhizomucor
miehei) 		PF01764
(Lipase_3) 		3 TYR A 172
THR A 198
THR A 141
 None
 0.74A 5aoxE-3tglA:
undetectable		 5aoxE-3tglA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uen DNA TOPOISOMERASE
2-BINDING PROTEIN 1

(Homo sapiens) 		PF12738
(PTCB-BRCT) 		3 TYR A 622
THR A 624
THR A 618
 None
 0.83A 5aoxE-3uenA:
undetectable		 5aoxE-3uenA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmn DEXTRANASE

(Streptococcus
mutans) 		PF13199
(Glyco_hydro_66) 		3 TYR A 731
THR A 690
THR A 635
 None
 0.69A 5aoxE-3vmnA:
0.1		 5aoxE-3vmnA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whe IMMUNOGLOBULIN HEAVY
CHAIN

(Homo sapiens) 		no annotation 3 TYR M  80
THR M  19
THR M  71
 None
 0.75A 5aoxE-3wheM:
undetectable		 5aoxE-3wheM:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq1 ENDOGLUCANASE A

(Pyrococcus
furiosus) 		PF01670
(Glyco_hydro_12) 		3 TYR A 158
THR A 160
THR A 311
 None
 0.59A 5aoxE-3wq1A:
undetectable		 5aoxE-3wq1A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		3 TYR A 266
THR A 268
THR A 328
 None
 0.82A 5aoxE-4a5wA:
2.5		 5aoxE-4a5wA:
5.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA

(Dictyostelium
discoideum) 		PF01267
(F-actin_cap_A) 		3 TYR A 138
THR A 140
THR A 149
 None
 0.81A 5aoxE-4akrA:
1.7		 5aoxE-4akrA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgd PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT) 		3 TYR C2208
THR C2250
THR C2223
 None
 0.81A 5aoxE-4bgdC:
undetectable		 5aoxE-4bgdC:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2t DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		3 TYR A 237
THR A 232
THR A 240
 None
 0.82A 5aoxE-4c2tA:
undetectable		 5aoxE-4c2tA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4foz PORIN D

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		3 TYR A 236
THR A 238
THR A 253
 None
 0.28A 5aoxE-4fozA:
0.5		 5aoxE-4fozA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gky PROTEIN ERGIC-53

(Homo sapiens) 		PF03388
(Lectin_leg-like) 		3 TYR A 208
THR A 211
THR A 206
 None
 0.78A 5aoxE-4gkyA:
undetectable		 5aoxE-4gkyA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu2 CELL-WALL ANCHORING
PROTEIN

(Ruminococcus
flavefaciens) 		PF00963
(Cohesin) 		3 TYR A  19
THR A  18
THR A 178
 None
 0.70A 5aoxE-4iu2A:
undetectable		 5aoxE-4iu2A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1x UNCHARACTERIZED
PROTEIN
201PHI2-1P060

(Pseudomonas
phage 201phi2-1) 		no annotation 3 TYR A  49
THR A  51
THR A  46
 None
 0.57A 5aoxE-4m1xA:
undetectable		 5aoxE-4m1xA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhc NUCLEOPORIN NUP157

(Saccharomyces
cerevisiae) 		PF08801
(Nucleoporin_N) 		3 TYR A 539
THR A 558
THR A 509
 None
 0.76A 5aoxE-4mhcA:
undetectable		 5aoxE-4mhcA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nps BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS

(Bartonella
clarridgeiae) 		PF02661
(Fic) 		3 TYR A 264
THR A 307
THR A 280
 None
 0.83A 5aoxE-4npsA:
undetectable		 5aoxE-4npsA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf1 PEPTIDASE
S15/COCE/NOND

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		3 TYR A 613
THR A 615
THR A 610
 None
 0.76A 5aoxE-4pf1A:
undetectable		 5aoxE-4pf1A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgs ALCOHOL
DEHYDROGENASE YQHD

(Escherichia
coli) 		PF00465
(Fe-ADH) 		3 TYR A 179
THR A 182
THR A 138
 None
 0.62A 5aoxE-4qgsA:
undetectable		 5aoxE-4qgsA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rfe FAB HEAVY CHAIN OF
ADCC-POTENT
ANTI-HIV-1 ANTIBODY
JR4

(Macaca mulatta) 		no annotation 3 TYR H  98
THR H 100
THR H 100
 None
 0.57A 5aoxE-4rfeH:
undetectable		 5aoxE-4rfeH:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2u RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Escherichia
coli) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		3 TYR A  91
THR A 127
THR A  59
 None
 0.82A 5aoxE-4s2uA:
undetectable		 5aoxE-4s2uA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u98 MALTOKINASE

(Mycolicibacterium
vanbaalenii) 		PF01636
(APH) 		3 TYR A  46
THR A  47
THR A  50
 None
 0.83A 5aoxE-4u98A:
undetectable		 5aoxE-4u98A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whb PHENYLUREA HYDROLASE
B

(Mycolicibacterium
brisbanense) 		no annotation 3 TYR E  61
THR E 108
THR E 394
 None
 0.65A 5aoxE-4whbE:
undetectable		 5aoxE-4whbE:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xny HEAVY CHAIN OF
ANTIBODY VRC08C

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR H  79
THR H  81
THR H  70
 None
 0.77A 5aoxE-4xnyH:
undetectable		 5aoxE-4xnyH:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylq COAGULATION FACTOR
VII

(Homo sapiens) 		PF00089
(Trypsin) 		3 TYR H 179
THR H 229
THR H 177
 None
 0.61A 5aoxE-4ylqH:
undetectable		 5aoxE-4ylqH:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		3 TYR A 497
THR A 527
THR A 471
 None
 0.83A 5aoxE-5a55A:
undetectable		 5aoxE-5a55A:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT K

(Oryctolagus
cuniculus) 		PF10075
(CSN8_PSD8_EIF3K) 		3 TYR K  32
THR K  28
THR K  35
 None
 0.83A 5aoxE-5a5tK:
undetectable		 5aoxE-5a5tK:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6s ENDOLYSIN

(Clostridium
phage phiCTP1) 		PF01183
(Glyco_hydro_25) 		3 TYR A 249
THR A 251
THR A 247
 None
 0.83A 5aoxE-5a6sA:
undetectable		 5aoxE-5a6sA:
13.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5aox SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN

(Homo sapiens) 		PF02290
(SRP14) 		3 TYR B  27
THR B  29
THR B  61
 U  C  24 ( 3.2A)
U  C  26 ( 4.6A)
U  C  24 (-4.2A)
 0.10A 5aoxE-5aoxB:
17.1		 5aoxE-5aoxB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c16 MYOTUBULARIN-RELATED
PROTEIN 1

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		3 TYR A 460
THR A 462
THR A 468
 None
 0.72A 5aoxE-5c16A:
undetectable		 5aoxE-5c16A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz8 BSPA (BSPA_V)

(Streptococcus
agalactiae) 		no annotation 3 TYR A 361
THR A 404
THR A 336
 None
 0.79A 5aoxE-5dz8A:
undetectable		 5aoxE-5dz8A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqx DESMOGLEIN-3

(Homo sapiens) 		PF00028
(Cadherin) 		3 TYR A 433
THR A 412
THR A 340
 None
 0.60A 5aoxE-5eqxA:
undetectable		 5aoxE-5eqxA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fok IRON TRANSPORT OUTER
MEMBRANE RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 TYR A 480
THR A 482
THR A 500
 None
 0.62A 5aoxE-5fokA:
undetectable		 5aoxE-5fokA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcc COMPLEMENT C5

(Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		3 TYR B 266
THR B 268
THR B 328
 None
 0.61A 5aoxE-5hccB:
undetectable		 5aoxE-5hccB:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jr4 TYPE 1 FIMBIRAL
ADHESIN FIMH

(Escherichia
coli) 		PF00419
(Fimbrial)
PF09160
(FimH_man-bind) 		3 TYR A 108
THR A 110
THR A  74
 None
 0.47A 5aoxE-5jr4A:
undetectable		 5aoxE-5jr4A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jui CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		no annotation 3 TYR A 228
THR A 215
THR A 247
 None
 0.82A 5aoxE-5juiA:
1.1		 5aoxE-5juiA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0w CLASS B
CARBAPENEMASE GOB-18

(Elizabethkingia
meningoseptica) 		PF00753
(Lactamase_B) 		3 TYR A 101
THR A 104
THR A 144
 None
 0.76A 5aoxE-5k0wA:
undetectable		 5aoxE-5k0wA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kku POLYKETIDE SYNTHASE
TYPE I

(Bacillus
amyloliquefaciens) 		PF14765
(PS-DH) 		3 TYR A  77
THR A  10
THR A  92
 None
 0.83A 5aoxE-5kkuA:
undetectable		 5aoxE-5kkuA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kku POLYKETIDE SYNTHASE
TYPE I

(Bacillus
amyloliquefaciens) 		PF14765
(PS-DH) 		3 TYR A  77
THR A  79
THR A  92
 None
 0.62A 5aoxE-5kkuA:
undetectable		 5aoxE-5kkuA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA

(Methylobacillus
flagellatus) 		PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		3 TYR C 254
THR C 256
THR C 252
 None
 0.81A 5aoxE-5ks8C:
undetectable		 5aoxE-5ks8C:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		3 TYR A 296
THR A 298
THR A 301
 NAG  A 506 ( 4.9A)
None
None
 0.74A 5aoxE-5m8tA:
undetectable		 5aoxE-5m8tA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5op0 DNA POLYMERASE LIGD,
POLYMERASE DOMAIN

(Mycolicibacterium
smegmatis) 		no annotation 3 TYR B 272
THR B 254
THR B 276
 None
 0.82A 5aoxE-5op0B:
undetectable		 5aoxE-5op0B:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vi4 INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN

(Mus musculus) 		PF13895
(Ig_2)
PF13927
(Ig_3) 		3 TYR C  71
THR C  73
THR C 113
 None
 0.75A 5aoxE-5vi4C:
2.0		 5aoxE-5vi4C:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmk BIFUNCTIONAL PROTEIN
GLMU

(Acinetobacter
baumannii) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3)
PF14602
(Hexapep_2) 		3 TYR A 194
THR A  79
THR A 196
 None
 0.60A 5aoxE-5vmkA:
undetectable		 5aoxE-5vmkA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmk BIFUNCTIONAL PROTEIN
GLMU

(Acinetobacter
baumannii) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3)
PF14602
(Hexapep_2) 		3 TYR A 363
THR A 362
THR A 381
 CIT  A 501 (-4.7A)
None
None
 0.82A 5aoxE-5vmkA:
undetectable		 5aoxE-5vmkA:
10.80