SIMILAR PATTERNS OF AMINO ACIDS FOR 5AMK_B_EF2B151

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bru ELASTASE

(Sus scrofa)
PF00089
(Trypsin)
4 ASN P 200
PRO P 198
TRP P  27
TRP P 207
None
1.47A 5amkB-1bruP:
0.0
5amkB-1bruP:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE


(Escherichia
coli)
PF00982
(Glyco_transf_20)
4 PRO A 158
PHE A  88
TRP A  85
TYR A 265
None
1.47A 5amkB-1gz5A:
0.0
5amkB-1gz5A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxy ARGININE DEIMINASE

(Mycoplasma
arginini)
PF02274
(Amidinotransf)
4 ASN A 260
PHE A 294
TRP A 295
TYR A 297
None
0.99A 5amkB-1lxyA:
undetectable
5amkB-1lxyA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xxr MANNOSE-BINDING
LECTIN


(Morus nigra)
PF01419
(Jacalin)
4 ASN A  86
PRO A  85
PHE A  84
TYR A 121
None
1.41A 5amkB-1xxrA:
0.0
5amkB-1xxrA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE


(Saccharomyces
cerevisiae)
PF00343
(Phosphorylase)
4 PRO A 229
PHE A 228
TRP A 155
TYR A 157
None
1.45A 5amkB-1ygpA:
0.0
5amkB-1ygpA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7l PHYCOERYTHROCYANIN
BETA CHAIN


(Mastigocladus
laminosus)
PF00502
(Phycobilisome)
4 ASN B  68
PRO B  69
PHE B  74
TYR B  56
None
1.26A 5amkB-2c7lB:
undetectable
5amkB-2c7lB:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocx NODULATION
FUCOSYLTRANSFERASE
NODZ


(Bradyrhizobium
sp. WM9)
PF05830
(NodZ)
4 ASN A 124
PRO A  81
PHE A   6
TYR A  28
None
PO4  A 332 ( 4.8A)
PO4  A 332 (-4.7A)
None
1.17A 5amkB-2ocxA:
undetectable
5amkB-2ocxA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w61 GLYCOLIPID-ANCHORED
SURFACE PROTEIN 2


(Saccharomyces
cerevisiae)
PF03198
(Glyco_hydro_72)
PF07983
(X8)
4 ASN A 141
PRO A 145
PHE A 189
TYR A 155
None
1.26A 5amkB-2w61A:
0.0
5amkB-2w61A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juu PORPHYRANASE B

(Zobellia
galactanivorans)
PF00722
(Glyco_hydro_16)
4 ASN A 261
PRO A 262
TRP A 260
TRP A 172
None
1.39A 5amkB-3juuA:
0.0
5amkB-3juuA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kie CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A)
PF00740
(Parvo_coat)
4 PRO A 308
PHE A 638
TRP A 619
TYR A 352
None
1.36A 5amkB-3kieA:
undetectable
5amkB-3kieA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens)
PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N)
4 ASN A 319
PRO A 315
PHE A 670
TYR A 660
None
1.49A 5amkB-3lppA:
undetectable
5amkB-3lppA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng9 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A)
PF00740
(Parvo_coat)
4 PRO A 309
PHE A 638
TRP A 619
TYR A 353
None
1.37A 5amkB-3ng9A:
undetectable
5amkB-3ng9A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE


(Cytophaga
hutchinsonii)
PF01494
(FAD_binding_3)
4 PRO A  50
PHE A  89
TRP A  99
TRP A 101
None
1.25A 5amkB-3nixA:
undetectable
5amkB-3nixA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntt CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
B)
PF00740
(Parvo_coat)
4 PRO A 299
PHE A 627
TRP A 608
TYR A 343
None
1.43A 5amkB-3nttA:
undetectable
5amkB-3nttA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei)
PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5)
4 PRO A  69
PHE A  70
TRP A 350
TYR A 948
None
1.41A 5amkB-3ogrA:
undetectable
5amkB-3ogrA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ra2 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A)
PF00740
(Parvo_coat)
4 PRO A 311
PHE A 640
TRP A 621
TYR A 355
None
1.32A 5amkB-3ra2A:
undetectable
5amkB-3ra2A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shm CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A)
PF00740
(Parvo_coat)
4 PRO A 309
PHE A 638
TRP A 619
TYR A 353
None
1.38A 5amkB-3shmA:
undetectable
5amkB-3shmA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux1 CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A)
PF00740
(Parvo_coat)
4 PRO A 310
PHE A 638
TRP A 619
TYR A 354
None
1.37A 5amkB-3ux1A:
undetectable
5amkB-3ux1A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE


(Streptomyces
avermitilis)
PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C)
4 PRO A 628
TRP A 347
TRP A 380
TYR A 350
None
1.26A 5amkB-3w5nA:
undetectable
5amkB-3w5nA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw7 GH86A
BETA-PORPHYRANASE


(Bacteroides
plebeius)
no annotation 4 ASN A 317
PRO A 274
PHE A 319
TYR A  49
None
IOD  A1704 ( 4.6A)
None
None
0.98A 5amkB-4aw7A:
undetectable
5amkB-4aw7A:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci2 PROTEIN CEREBLON

(Gallus gallus)
PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18)
5 ASN B 353
PRO B 354
TRP B 382
TRP B 388
TRP B 402
LVY  B1429 (-4.1A)
LVY  B1429 (-4.7A)
LVY  B1429 (-3.1A)
LVY  B1429 (-3.5A)
LVY  B1429 (-3.7A)
0.46A 5amkB-4ci2B:
16.3
5amkB-4ci2B:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iov CAPSID PROTEIN VP1

(Adeno-associated
virus)
PF00740
(Parvo_coat)
4 PRO A 299
PHE A 635
TRP A 616
TYR A 343
None
1.36A 5amkB-4iovA:
undetectable
5amkB-4iovA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae)
PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5)
4 PRO A  69
PHE A  70
TRP A 350
TYR A 930
None
1.39A 5amkB-4iugA:
undetectable
5amkB-4iugA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqf PROTEIN RECA

(Mycobacterium
tuberculosis)
PF00154
(RecA)
4 ASN A 250
PRO A 255
PHE A 256
TYR A  66
None
None
None
EDO  A 402 (-4.8A)
1.32A 5amkB-4oqfA:
undetectable
5amkB-4oqfA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9g MBP1

(Caldanaerobius
polysaccharolyticus)
PF13416
(SBP_bac_8)
4 ASN A 391
PRO A 194
PHE A 394
TYR A 399
MAN  A 501 ( 4.9A)
None
None
None
1.47A 5amkB-4r9gA:
undetectable
5amkB-4r9gA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rso CAPSID PROTEIN VP1

(Non-human
primate
Adeno-associated
virus)
PF00740
(Parvo_coat)
4 PRO A 310
PHE A 638
TRP A 619
TYR A 354
None
1.40A 5amkB-4rsoA:
undetectable
5amkB-4rsoA:
12.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4v30 CEREBLON ISOFORM 4

(Magnetospirillum
gryphiswaldense)
no annotation 7 ASN A  50
PRO A  51
PHE A  77
TRP A  79
TRP A  85
TRP A  99
TYR A 101
LVY  A 151 (-3.8A)
LVY  A 151 (-4.4A)
LVY  A 151 (-4.4A)
LVY  A 151 (-3.2A)
LVY  A 151 (-3.4A)
LVY  A 151 (-3.7A)
LVY  A 151 (-4.7A)
0.16A 5amkB-4v30A:
22.5
5amkB-4v30A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5z CHITINASE 60

(Moritella
marina)
PF00704
(Glyco_hydro_18)
4 ASN A 314
PRO A  52
TRP A  40
TRP A 311
None
None
CL  A 408 (-4.3A)
MPD  A 402 ( 3.4A)
1.47A 5amkB-4w5zA:
undetectable
5amkB-4w5zA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE


(Aspergillus
flavus)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
4 ASN A 318
PHE A 414
TRP A 415
TYR A 337
LGC  A 602 ( 4.4A)
None
None
None
1.44A 5amkB-4ynuA:
undetectable
5amkB-4ynuA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huu ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
[UDP-FORMING]


(Candida
albicans)
PF00982
(Glyco_transf_20)
4 PRO A 175
PHE A 101
TRP A  98
TYR A 283
None
1.44A 5amkB-5huuA:
undetectable
5amkB-5huuA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvm ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)


(Aspergillus
fumigatus)
PF00982
(Glyco_transf_20)
4 PRO A 183
PHE A 109
TRP A 106
TYR A 290
None
1.49A 5amkB-5hvmA:
undetectable
5amkB-5hvmA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb PROTEIN CEREBLON

(Homo sapiens)
no annotation 5 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
0.59A 5amkB-5hxbZ:
11.6
5amkB-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A


(Aspergillus
niger)
PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5)
4 PRO A  69
PHE A  70
TRP A 350
TYR A 932
None
1.41A 5amkB-5ihrA:
undetectable
5amkB-5ihrA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koh NITROGENASE FEMO
BETA SUBUNIT PROTEIN
NIFK


(Gluconacetobacter
diazotrophicus)
PF00148
(Oxidored_nitro)
PF11844
(DUF3364)
4 ASN B 440
PRO B 460
PHE B 459
TYR B 313
None
1.36A 5amkB-5kohB:
undetectable
5amkB-5kohB:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME


(Lysobacter sp.
XL1)
no annotation 4 ASN A  65
PRO A  64
PHE A  63
TYR A 198
NA  A 305 (-3.4A)
None
None
None
1.49A 5amkB-5mrtA:
undetectable
5amkB-5mrtA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0t ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)


(Paraburkholderia
xenovorans)
PF00982
(Glyco_transf_20)
4 PRO A 168
PHE A  98
TRP A  95
TYR A 280
None
1.46A 5amkB-5v0tA:
undetectable
5amkB-5v0tA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8g 2-SUCCINYLBENZOATE--
COA LIGASE


(Bacillus
subtilis)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
4 ASN A 342
PRO A 341
PHE A 171
TYR A 209
None
1.34A 5amkB-5x8gA:
undetectable
5amkB-5x8gA:
14.96