SIMILAR PATTERNS OF AMINO ACIDS FOR 5AMK_A_EF2A151_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a2v | METHYLAMINE OXIDASE (Ogataea angusta) |
PF01179(Cu_amine_oxid)PF02727(Cu_amine_oxidN2)PF02728(Cu_amine_oxidN3) | 4 | ASN A 652PRO A 653PHE A 649TYR A 534 | None | 1.31A | 5amkA-1a2vA:undetectable | 5amkA-1a2vA:11.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fcu | HYALURONOGLUCOSAMINIDASE (Apis mellifera) |
PF01630(Glyco_hydro_56) | 4 | ASN A 75PHE A 60TRP A 115TYR A 129 | None | 1.10A | 5amkA-1fcuA:0.0 | 5amkA-1fcuA:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ljy | MGP-40 (Capra hircus) |
PF00704(Glyco_hydro_18) | 4 | PHE A 37TRP A 78TRP A 331TYR A 185 | None | 1.44A | 5amkA-1ljyA:undetectable | 5amkA-1ljyA:17.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lu4 | SOLUBLE SECRETEDANTIGEN MPT53 (Mycobacteriumtuberculosis) |
PF00578(AhpC-TSA) | 4 | ASN A1040PHE A1073PHE A1038TRP A1030 | None | 1.37A | 5amkA-1lu4A:0.0 | 5amkA-1lu4A:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ocx | MALTOSEO-ACETYLTRANSFERASE (Escherichiacoli) |
PF12464(Mac)PF14602(Hexapep_2) | 4 | ASN A 83PRO A 104PHE A 81TYR A 35 | None | 1.17A | 5amkA-1ocxA:undetectable | 5amkA-1ocxA:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qs0 | 2-OXOISOVALERATEDEHYDROGENASEBETA-SUBUNIT (Pseudomonasputida) |
PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | PRO B 190PHE B 183TRP B 320TYR B 126 | None | 1.37A | 5amkA-1qs0B:0.0 | 5amkA-1qs0B:17.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s44 | CRUSTACYANIN A1SUBUNIT (Homarusgammarus) |
PF00061(Lipocalin) | 4 | ASN A 43PRO A 44PHE A 134PHE A 6 | MPD A 482 (-3.3A)NoneMPD A 481 ( 3.8A)None | 1.05A | 5amkA-1s44A:0.0 | 5amkA-1s44A:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ton | TONIN (Rattus rattus) |
PF00089(Trypsin) | 4 | ASN A 245PRO A 246PHE A 89TRP A 51 | None | 1.38A | 5amkA-1tonA:0.2 | 5amkA-1tonA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uf2 | OUTER CAPSID PROTEINP8 (Rice dwarfvirus) |
no annotation | 4 | PHE P 68TRP P 86TRP P 6TYR P 80 | None | 1.39A | 5amkA-1uf2P:0.0 | 5amkA-1uf2P:15.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1urd | MALTOSE-BINDINGPROTEIN (Alicyclobacillusacidocaldarius) |
PF01547(SBP_bac_1) | 4 | ASN A 69PHE A 75TRP A 37TRP A 35 | None | 1.02A | 5amkA-1urdA:undetectable | 5amkA-1urdA:15.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v0d | DNA FRAGMENTATIONFACTOR 40 KDASUBUNIT (Mus musculus) |
PF09230(DFF40) | 4 | ASN A 245PRO A 246PHE A 256TRP A 259 | None | 1.43A | 5amkA-1v0dA:undetectable | 5amkA-1v0dA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c7l | PHYCOERYTHROCYANINBETA CHAIN (Mastigocladuslaminosus) |
PF00502(Phycobilisome) | 4 | ASN B 68PRO B 69PHE B 74TYR B 56 | None | 1.39A | 5amkA-2c7lB:undetectable | 5amkA-2c7lB:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cc3 | PROTEIN VIRB8 (Agrobacteriumtumefaciens) |
PF04335(VirB8) | 4 | ASN A 213PRO A 214PHE A 127TYR A 119 | NoneNoneNoneMPD A1232 (-4.5A) | 1.47A | 5amkA-2cc3A:undetectable | 5amkA-2cc3A:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cug | MKIAA0962 PROTEIN (Mus musculus) |
PF00226(DnaJ) | 4 | ASN A 50PRO A 47PHE A 59TRP A 45 | None | 1.42A | 5amkA-2cugA:undetectable | 5amkA-2cugA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eg9 | ADP-RIBOSYL CYCLASE1 (Mus musculus) |
PF02267(Rib_hydrolayse) | 4 | ASN A 187PRO A 188PHE A 97TRP A 53 | None | 1.40A | 5amkA-2eg9A:undetectable | 5amkA-2eg9A:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ic7 | MALTOSETRANSACETYLASE (Geobacilluskaustophilus) |
PF00132(Hexapep)PF12464(Mac)PF14602(Hexapep_2) | 4 | ASN A 84PRO A 105PHE A 82TYR A 35 | None | 1.32A | 5amkA-2ic7A:undetectable | 5amkA-2ic7A:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2imj | HYPOTHETICAL PROTEINDUF1348 (Pseudomonasprotegens) |
PF07080(DUF1348) | 4 | ASN A 50PHE A 64TRP A 48TRP A 30 | NoneNoneNoneACT A 201 (-4.2A) | 1.00A | 5amkA-2imjA:undetectable | 5amkA-2imjA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2okx | RHAMNOSIDASE B (Bacillus sp.GL1) |
PF05592(Bac_rhamnosid)PF08531(Bac_rhamnosid_N)PF17389(Bac_rhamnosid6H)PF17390(Bac_rhamnosid_C) | 4 | ASN A 628PRO A 627PHE A 632TRP A 629 | NoneNoneNoneGOL A3007 (-3.9A) | 1.44A | 5amkA-2okxA:undetectable | 5amkA-2okxA:8.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2otb | GFP-LIKE FLUORESCENTCHROMOPROTEIN CFP484 (Clavularia sp.) |
PF01353(GFP) | 4 | ASN A 63PHE A 177TRP A 93TYR A 181 | PIA A 66 ( 4.5A)NonePIA A 66 ( 4.1A)None | 1.20A | 5amkA-2otbA:undetectable | 5amkA-2otbA:17.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pka | KALLIKREIN A (Sus scrofa) |
PF00089(Trypsin) | 4 | ASN B 245PRO B 246PHE A 89TRP A 51 | None | 1.44A | 5amkA-2pkaB:undetectable | 5amkA-2pkaB:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2reb | REC A (Escherichiacoli) |
PF00154(RecA) | 4 | ASN A 249PRO A 254PHE A 255TYR A 65 | None | 1.49A | 5amkA-2rebA:undetectable | 5amkA-2rebA:16.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rez | MULTIFUNCTIONALCYCLASE-DEHYDRATASE-3-O-METHYLTRANSFERASE TCMN (Streptomycesglaucescens) |
PF03364(Polyketide_cyc) | 4 | ASN A 136PHE A 32TRP A 95TYR A 97 | None | 1.43A | 5amkA-2rezA:undetectable | 5amkA-2rezA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w61 | GLYCOLIPID-ANCHOREDSURFACE PROTEIN 2 (Saccharomycescerevisiae) |
PF03198(Glyco_hydro_72)PF07983(X8) | 4 | ASN A 141PRO A 145PHE A 189TYR A 155 | None | 1.39A | 5amkA-2w61A:undetectable | 5amkA-2w61A:10.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xr1 | CLEAVAGE ANDPOLYADENYLATIONSPECIFICITY FACTOR100 KD SUBUNIT (Methanosarcinamazei) |
PF07521(RMMBL)PF07650(KH_2)PF10996(Beta-Casp)PF16661(Lactamase_B_6)PF17214(KH_7) | 4 | PRO A 414PHE A 416PHE A 533TYR A 380 | None | 1.24A | 5amkA-2xr1A:undetectable | 5amkA-2xr1A:12.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yy7 | L-THREONINEDEHYDROGENASE (Flavobacteriumfrigidimaris) |
PF01370(Epimerase) | 4 | PRO A 280PHE A 122TRP A 279TYR A 143 | NoneNoneNoneGOL A1001 ( 4.1A) | 1.31A | 5amkA-2yy7A:undetectable | 5amkA-2yy7A:15.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a1n | NDP-SUGAR EPIMERASE (Thermoplasmavolcanium) |
PF01370(Epimerase) | 4 | PRO A 274PHE A 116TRP A 273TYR A 137 | NoneNoneNoneNAD A3001 (-4.2A) | 1.35A | 5amkA-3a1nA:undetectable | 5amkA-3a1nA:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bm3 | PSPGI RESTRICTIONENDONUCLEASE (Pyrococcus sp.GI-H) |
PF09019(EcoRII-C) | 4 | ASN A 186PHE A 256PHE A 187TRP A 188 | None | 1.41A | 5amkA-3bm3A:undetectable | 5amkA-3bm3A:18.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bm3 | PSPGI RESTRICTIONENDONUCLEASE (Pyrococcus sp.GI-H) |
PF09019(EcoRII-C) | 4 | ASN A 186PHE A 256PHE A 187TYR A 213 | None | 1.44A | 5amkA-3bm3A:undetectable | 5amkA-3bm3A:18.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cfi | TYPE II SECRETORYPATHWAY, PSEUDOPILINEPSJ (Vibriovulnificus) |
PF11612(T2SSJ) | 4 | ASN B 98PRO B 99PHE B 103TRP B 124 | None | 1.45A | 5amkA-3cfiB:undetectable | 5amkA-3cfiB:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dxq | CHOLINE/ETHANOLAMINEKINASE FAMILYPROTEIN (Mesorhizobiumloti) |
PF01633(Choline_kinase) | 4 | ASN A 265PHE A 270TRP A 256TYR A 136 | None | 1.38A | 5amkA-3dxqA:undetectable | 5amkA-3dxqA:17.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gdc | MULTICOPPER OXIDASE (Arthrobactersp. FB24) |
PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | ASN A 93PRO A 124PHE A 91TRP A 68 | None | 1.40A | 5amkA-3gdcA:undetectable | 5amkA-3gdcA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hjj | MALTOSEO-ACETYLTRANSFERASE (Bacillusanthracis) |
PF12464(Mac)PF14602(Hexapep_2) | 4 | ASN A 85PRO A 106PHE A 83TYR A 35 | ACY A 190 (-3.6A)ACY A 190 ( 4.7A)ACY A 190 ( 4.8A)None | 1.34A | 5amkA-3hjjA:undetectable | 5amkA-3hjjA:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hmj | FATTY ACID SYNTHASESUBUNIT ALPHA (Saccharomycescerevisiae) |
PF00109(ketoacyl-synt)PF01648(ACPS)PF02801(Ketoacyl-synt_C) | 4 | ASN A 829PRO A 828PHE A 833TRP A 871 | None | 1.10A | 5amkA-3hmjA:undetectable | 5amkA-3hmjA:5.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | PRE-MRNA-SPLICINGFACTOR SPP42 (Schizosaccharomycespombe) |
PF08082(PRO8NT)PF08083(PROCN)PF10596(U6-snRNA_bdg)PF10597(U5_2-snRNA_bdg)PF10598(RRM_4)PF12134(PRP8_domainIV) | 4 | ASN A1835PRO A1836PHE A1842PHE A1803 | None | 1.41A | 5amkA-3jb9A:undetectable | 5amkA-3jb9A:4.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3juu | PORPHYRANASE B (Zobelliagalactanivorans) |
PF00722(Glyco_hydro_16) | 4 | ASN A 261PRO A 262TRP A 260TRP A 172 | None | 1.38A | 5amkA-3juuA:undetectable | 5amkA-3juuA:16.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nap | CAPSID PROTEIN (Triatoma virus) |
PF08762(CRPV_capsid) | 4 | ASN A 77PRO A 78PHE A 99TYR A 70 | None | 1.36A | 5amkA-3napA:undetectable | 5amkA-3napA:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3opw | DNADAMAGE-RESPONSIVETRANSCRIPTIONALREPRESSOR RPH1 (Saccharomycescerevisiae) |
PF02373(JmjC)PF02375(JmjN) | 4 | ASN A 200PHE A 27TRP A 52TYR A 21 | None | 1.26A | 5amkA-3opwA:undetectable | 5amkA-3opwA:15.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pe7 | OLIGOGALACTURONATELYASE (Yersiniaenterocolitica) |
PF14583(Pectate_lyase22) | 4 | PRO A 375PHE A 84PHE A 345TRP A 60 | None | 1.31A | 5amkA-3pe7A:undetectable | 5amkA-3pe7A:17.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3som | METHYLMALONICACIDURIA ANDHOMOCYSTINURIA TYPEC PROTEIN (Homo sapiens) |
PF16690(MMACHC) | 4 | PRO A 56PHE A 223PHE A 154TYR A 205 | NoneFLC A 501 (-3.9A)NoneNone | 1.17A | 5amkA-3somA:undetectable | 5amkA-3somA:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w5n | PUTATIVERHAMNOSIDASE (Streptomycesavermitilis) |
PF05592(Bac_rhamnosid)PF08531(Bac_rhamnosid_N)PF17389(Bac_rhamnosid6H)PF17390(Bac_rhamnosid_C) | 4 | PRO A 628TRP A 347TRP A 380TYR A 350 | None | 1.23A | 5amkA-3w5nA:undetectable | 5amkA-3w5nA:8.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wmx | NAD DEPENDENTEPIMERASE/DEHYDRATASE (Cupriavidusnecator) |
PF01370(Epimerase) | 4 | PRO A 281PHE A 123TRP A 280TYR A 144 | NoneNoneNoneNAD A 401 ( 4.4A) | 1.31A | 5amkA-3wmxA:undetectable | 5amkA-3wmxA:15.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aw7 | GH86ABETA-PORPHYRANASE (Bacteroidesplebeius) |
no annotation | 4 | ASN A 317PRO A 274PHE A 319TYR A 49 | NoneIOD A1704 ( 4.6A)NoneNone | 1.12A | 5amkA-4aw7A:undetectable | 5amkA-4aw7A:11.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ce4 | MRPL38 (Sus scrofa) |
no annotation | 4 | ASN b 191PRO b 186PHE b 319TYR b 158 | None | 1.24A | 5amkA-4ce4b:undetectable | 5amkA-4ce4b:17.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ci2 | PROTEIN CEREBLON (Gallus gallus) |
PF02190(LON_substr_bdg)PF03226(Yippee-Mis18) | 5 | ASN B 353PRO B 354TRP B 382TRP B 388TRP B 402 | LVY B1429 (-4.1A)LVY B1429 (-4.7A)LVY B1429 (-3.1A)LVY B1429 (-3.5A)LVY B1429 (-3.7A) | 0.46A | 5amkA-4ci2B:16.2 | 5amkA-4ci2B:16.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gbr | BETA-2 ADRENERGICRECEPTOR (Homo sapiens) |
PF00001(7tm_1) | 4 | PHE A 104TRP A 99TRP A 105TRP A 109 | None | 1.50A | 5amkA-4gbrA:undetectable | 5amkA-4gbrA:16.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hgz | CCBJ (Streptomycescaelestis) |
PF13649(Methyltransf_25) | 4 | ASN A 152PRO A 153PHE A 239TYR A 250 | None | 0.99A | 5amkA-4hgzA:undetectable | 5amkA-4hgzA:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jmq | BACTERIOPHAGE T5DISTAL TAIL PROTEIN (Escherichiavirus T5) |
no annotation | 4 | ASN A 9PRO A 10PHE A 64TYR A 54 | None | 1.43A | 5amkA-4jmqA:undetectable | 5amkA-4jmqA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l7a | UNCHARACTERIZEDPROTEIN (Bacteroidescaccae) |
PF15890(Peptidase_Mx1) | 4 | ASN A 59PRO A 60TRP A 52TYR A 297 | None | 1.14A | 5amkA-4l7aA:undetectable | 5amkA-4l7aA:17.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oqf | PROTEIN RECA (Mycobacteriumtuberculosis) |
PF00154(RecA) | 4 | ASN A 250PRO A 255PHE A 256TYR A 66 | NoneNoneNoneEDO A 402 (-4.8A) | 1.42A | 5amkA-4oqfA:undetectable | 5amkA-4oqfA:17.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ovn | SODIUM CHANNELPROTEIN TYPE 5SUBUNIT ALPHA (Homo sapiens) |
PF16905(GPHH) | 4 | ASN F1883PRO F1884PHE F1879TYR F1795 | None | 1.40A | 5amkA-4ovnF:undetectable | 5amkA-4ovnF:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p05 | ARYLSULFATESULFOTRANSFERASEASST (Escherichiacoli) |
PF05935(Arylsulfotrans)PF17425(Arylsulfotran_N) | 4 | PHE A 231PHE A 178TRP A 188TRP A 189 | None | 1.09A | 5amkA-4p05A:undetectable | 5amkA-4p05A:13.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r9g | MBP1 (Caldanaerobiuspolysaccharolyticus) |
PF13416(SBP_bac_8) | 4 | ASN A 391PRO A 194PHE A 394TYR A 399 | MAN A 501 ( 4.9A)NoneNoneNone | 1.44A | 5amkA-4r9gA:undetectable | 5amkA-4r9gA:17.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tx8 | PROBABLE CHITINASE A (Chromobacteriumviolaceum) |
PF00704(Glyco_hydro_18) | 4 | ASN A 94PRO A 95PHE A 92TRP A 374 | NoneNoneNoneFLC A 505 (-3.0A) | 1.44A | 5amkA-4tx8A:undetectable | 5amkA-4tx8A:15.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4v30 | CEREBLON ISOFORM 4 (Magnetospirillumgryphiswaldense) |
no annotation | 8 | ASN A 50PRO A 51PHE A 56PHE A 77TRP A 79TRP A 85TRP A 99TYR A 101 | LVY A 151 (-3.8A)LVY A 151 (-4.4A)NoneLVY A 151 (-4.4A)LVY A 151 (-3.2A)LVY A 151 (-3.4A)LVY A 151 (-3.7A)LVY A 151 (-4.7A) | 0.56A | 5amkA-4v30A:22.2 | 5amkA-4v30A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wva | UNCHARACTERIZEDPROTEIN (Thermusthermophilus) |
PF01204(Trehalase) | 4 | ASN A 357PHE A 38TRP A 418TRP A 360 | None | 1.39A | 5amkA-4wvaA:undetectable | 5amkA-4wvaA:14.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yh8 | SPLICING FACTOR U2AF23 KDA SUBUNIT (Schizosaccharomycespombe) |
PF00076(RRM_1)PF00642(zf-CCCH) | 4 | ASN A 60PRO A 59PHE A 64TYR A 52 | None | 1.42A | 5amkA-4yh8A:undetectable | 5amkA-4yh8A:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ynu | GLUCOSE OXIDASE,PUTATIVE (Aspergillusflavus) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 4 | ASN A 318PHE A 414TRP A 415TYR A 337 | LGC A 602 ( 4.4A)NoneNoneNone | 1.26A | 5amkA-4ynuA:undetectable | 5amkA-4ynuA:12.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z5v | NON-STRUCTURALPROTEIN 2A (Murinecoronavirus) |
PF05213(Corona_NS2A) | 4 | ASN A 12PRO A 14PHE A 10PHE A 13 | None | 1.38A | 5amkA-4z5vA:undetectable | 5amkA-4z5vA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z7x | MDBA (Actinomycesoris) |
PF13462(Thioredoxin_4) | 4 | PHE A 135PHE A 198TRP A 113TYR A 115 | NoneNoneNone3CX A 501 (-4.6A) | 1.18A | 5amkA-4z7xA:undetectable | 5amkA-4z7xA:17.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d0n | PYRUVATE, PHOSPHATEDIKINASE REGULATORYPROTEIN,CHLOROPLASTIC (Zea mays) |
PF03618(Kinase-PPPase) | 4 | PRO A 390PHE A 383PHE A 337TRP A 389 | None | 1.42A | 5amkA-5d0nA:undetectable | 5amkA-5d0nA:15.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dj4 | SESTRIN-2 (Homo sapiens) |
PF04636(PA26) | 4 | PHE A 367PHE A 401TRP A 394TYR A 405 | None | 1.30A | 5amkA-5dj4A:undetectable | 5amkA-5dj4A:13.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h05 | AMYP (marinemetagenome) |
PF00128(Alpha-amylase) | 4 | ASN A 148PRO A 149PHE A 90TYR A 94 | NoneNoneMLR A 701 (-4.5A)None | 1.11A | 5amkA-5h05A:undetectable | 5amkA-5h05A:12.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hxb | PROTEIN CEREBLON (Homo sapiens) |
no annotation | 5 | ASN Z 351PRO Z 352TRP Z 380TRP Z 386TRP Z 400 | 85C Z 502 (-3.6A)85C Z 502 (-4.4A)85C Z 502 (-3.2A)85C Z 502 (-3.4A)85C Z 502 (-3.7A) | 0.62A | 5amkA-5hxbZ:11.5 | 5amkA-5hxbZ:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hzr | SNF2-FAMILY ATPDEPENDENT CHROMATINREMODELING FACTORLIKE PROTEIN (Thermothelomycesthermophila) |
PF00176(SNF2_N)PF00271(Helicase_C)PF14619(SnAC) | 4 | ASN A 859PRO A 860PHE A 849TYR A1112 | None | 1.07A | 5amkA-5hzrA:undetectable | 5amkA-5hzrA:9.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k50 | L-THREONINE3-DEHYDROGENASE (Trypanosomabrucei) |
no annotation | 4 | PRO A1281PHE A1123TRP A1280TYR A1144 | NoneNoneNoneGOL A1402 ( 4.3A) | 1.21A | 5amkA-5k50A:undetectable | 5amkA-5k50A:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kn7 | LIPID A BIOSYNTHESISLAUROYLACYLTRANSFERASE (Acinetobacterbaumannii) |
PF03279(Lip_A_acyltrans) | 4 | PRO B 121PHE B 123TRP B 126TYR B 79 | NoneNoneGOL B 409 (-4.6A)LMT B 415 (-3.8A) | 1.32A | 5amkA-5kn7B:undetectable | 5amkA-5kn7B:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uj6 | GLYCOSYL HYDROLASESFAMILY 2, SUGARBINDING DOMAINPROTEIN (Bacteroidesuniformis) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF11721(Malectin)PF16355(DUF4982) | 4 | ASN A 592PHE A 545TRP A 498TYR A 553 | None | 1.48A | 5amkA-5uj6A:undetectable | 5amkA-5uj6A:10.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ukb | ANTI-VESICULARSTOMATITIS VIRUS NVHH (Vicugna pacos) |
no annotation | 4 | PRO d 105PHE d 37PHE d 99TRP d 114 | None | 1.25A | 5amkA-5ukbd:undetectable | 5amkA-5ukbd:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wjp | CYCLOHEXADIENYLDEHYDRATASE (CandidatusPelagibacterubique) |
PF00497(SBP_bac_3) | 4 | ASN A 204PRO A 205PHE A 151TRP A 126 | None | 1.49A | 5amkA-5wjpA:undetectable | 5amkA-5wjpA:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x4s | SPIKE GLYCOPROTEIN (Severe acuterespiratorysyndrome-relatedcoronavirus) |
PF16451(Spike_NTD) | 4 | ASN A 78PRO A 79PHE A 76PHE A 69 | None | 1.34A | 5amkA-5x4sA:undetectable | 5amkA-5x4sA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x6s | ACETYLXYLAN ESTERASEA (Aspergillusawamori) |
PF10503(Esterase_phd) | 4 | ASN A 13PRO A 14PHE A 10TYR A 132 | None | 1.33A | 5amkA-5x6sA:undetectable | 5amkA-5x6sA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x8g | 2-SUCCINYLBENZOATE--COA LIGASE (Bacillussubtilis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 4 | ASN A 342PRO A 341PHE A 171TYR A 209 | None | 1.29A | 5amkA-5x8gA:undetectable | 5amkA-5x8gA:14.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xgj | PHOSPHATIDYLINOSITOL4,5-BISPHOSPHATE3-KINASE CATALYTICSUBUNIT ALPHAISOFORM (Homo sapiens) |
no annotation | 4 | ASN A 785PRO A 786PHE A 794TRP A 783 | None | 1.50A | 5amkA-5xgjA:undetectable | 5amkA-5xgjA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y1g | NAD DEPENDENTEPIMERASE/DEHYDRATASE FAMILY (unculturedarchaeonMedDCM-OCT-S05-C57) |
no annotation | 4 | PRO A 272PHE A 115TRP A 271TYR A 136 | NoneNoneAKB A 401 (-4.5A)AKB A 401 (-4.5A) | 1.36A | 5amkA-5y1gA:undetectable | 5amkA-5y1gA:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5znp | SHORT LIFE FAMILYPROTEIN (Populustrichocarpa) |
no annotation | 4 | ASN A 134PRO A 135PHE A 124TYR A 64 | None | 1.38A | 5amkA-5znpA:undetectable | 5amkA-5znpA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f4f | GLUTATHIONETRANSFERASE (Trametesversicolor) |
no annotation | 4 | PRO A 16PHE A 216PHE A 168TYR A 206 | None | 1.49A | 5amkA-6f4fA:undetectable | 5amkA-6f4fA:18.85 |