SIMILAR PATTERNS OF AMINO ACIDS FOR 5AMK_A_EF2A151_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2v METHYLAMINE OXIDASE

(Ogataea angusta)
PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
4 ASN A 652
PRO A 653
PHE A 649
TYR A 534
None
1.31A 5amkA-1a2vA:
undetectable
5amkA-1a2vA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcu HYALURONOGLUCOSAMINI
DASE


(Apis mellifera)
PF01630
(Glyco_hydro_56)
4 ASN A  75
PHE A  60
TRP A 115
TYR A 129
None
1.10A 5amkA-1fcuA:
0.0
5amkA-1fcuA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ljy MGP-40

(Capra hircus)
PF00704
(Glyco_hydro_18)
4 PHE A  37
TRP A  78
TRP A 331
TYR A 185
None
1.44A 5amkA-1ljyA:
undetectable
5amkA-1ljyA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lu4 SOLUBLE SECRETED
ANTIGEN MPT53


(Mycobacterium
tuberculosis)
PF00578
(AhpC-TSA)
4 ASN A1040
PHE A1073
PHE A1038
TRP A1030
None
1.37A 5amkA-1lu4A:
0.0
5amkA-1lu4A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocx MALTOSE
O-ACETYLTRANSFERASE


(Escherichia
coli)
PF12464
(Mac)
PF14602
(Hexapep_2)
4 ASN A  83
PRO A 104
PHE A  81
TYR A  35
None
1.17A 5amkA-1ocxA:
undetectable
5amkA-1ocxA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs0 2-OXOISOVALERATE
DEHYDROGENASE
BETA-SUBUNIT


(Pseudomonas
putida)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
4 PRO B 190
PHE B 183
TRP B 320
TYR B 126
None
1.37A 5amkA-1qs0B:
0.0
5amkA-1qs0B:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s44 CRUSTACYANIN A1
SUBUNIT


(Homarus
gammarus)
PF00061
(Lipocalin)
4 ASN A  43
PRO A  44
PHE A 134
PHE A   6
MPD  A 482 (-3.3A)
None
MPD  A 481 ( 3.8A)
None
1.05A 5amkA-1s44A:
0.0
5amkA-1s44A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ton TONIN

(Rattus rattus)
PF00089
(Trypsin)
4 ASN A 245
PRO A 246
PHE A  89
TRP A  51
None
1.38A 5amkA-1tonA:
0.2
5amkA-1tonA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 OUTER CAPSID PROTEIN
P8


(Rice dwarf
virus)
no annotation 4 PHE P  68
TRP P  86
TRP P   6
TYR P  80
None
1.39A 5amkA-1uf2P:
0.0
5amkA-1uf2P:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urd MALTOSE-BINDING
PROTEIN


(Alicyclobacillus
acidocaldarius)
PF01547
(SBP_bac_1)
4 ASN A  69
PHE A  75
TRP A  37
TRP A  35
None
1.02A 5amkA-1urdA:
undetectable
5amkA-1urdA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0d DNA FRAGMENTATION
FACTOR 40 KDA
SUBUNIT


(Mus musculus)
PF09230
(DFF40)
4 ASN A 245
PRO A 246
PHE A 256
TRP A 259
None
1.43A 5amkA-1v0dA:
undetectable
5amkA-1v0dA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7l PHYCOERYTHROCYANIN
BETA CHAIN


(Mastigocladus
laminosus)
PF00502
(Phycobilisome)
4 ASN B  68
PRO B  69
PHE B  74
TYR B  56
None
1.39A 5amkA-2c7lB:
undetectable
5amkA-2c7lB:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cc3 PROTEIN VIRB8

(Agrobacterium
tumefaciens)
PF04335
(VirB8)
4 ASN A 213
PRO A 214
PHE A 127
TYR A 119
None
None
None
MPD  A1232 (-4.5A)
1.47A 5amkA-2cc3A:
undetectable
5amkA-2cc3A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cug MKIAA0962 PROTEIN

(Mus musculus)
PF00226
(DnaJ)
4 ASN A  50
PRO A  47
PHE A  59
TRP A  45
None
1.42A 5amkA-2cugA:
undetectable
5amkA-2cugA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg9 ADP-RIBOSYL CYCLASE
1


(Mus musculus)
PF02267
(Rib_hydrolayse)
4 ASN A 187
PRO A 188
PHE A  97
TRP A  53
None
1.40A 5amkA-2eg9A:
undetectable
5amkA-2eg9A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ic7 MALTOSE
TRANSACETYLASE


(Geobacillus
kaustophilus)
PF00132
(Hexapep)
PF12464
(Mac)
PF14602
(Hexapep_2)
4 ASN A  84
PRO A 105
PHE A  82
TYR A  35
None
1.32A 5amkA-2ic7A:
undetectable
5amkA-2ic7A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imj HYPOTHETICAL PROTEIN
DUF1348


(Pseudomonas
protegens)
PF07080
(DUF1348)
4 ASN A  50
PHE A  64
TRP A  48
TRP A  30
None
None
None
ACT  A 201 (-4.2A)
1.00A 5amkA-2imjA:
undetectable
5amkA-2imjA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1)
PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C)
4 ASN A 628
PRO A 627
PHE A 632
TRP A 629
None
None
None
GOL  A3007 (-3.9A)
1.44A 5amkA-2okxA:
undetectable
5amkA-2okxA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otb GFP-LIKE FLUORESCENT
CHROMOPROTEIN CFP484


(Clavularia sp.)
PF01353
(GFP)
4 ASN A  63
PHE A 177
TRP A  93
TYR A 181
PIA  A  66 ( 4.5A)
None
PIA  A  66 ( 4.1A)
None
1.20A 5amkA-2otbA:
undetectable
5amkA-2otbA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pka KALLIKREIN A

(Sus scrofa)
PF00089
(Trypsin)
4 ASN B 245
PRO B 246
PHE A  89
TRP A  51
None
1.44A 5amkA-2pkaB:
undetectable
5amkA-2pkaB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2reb REC A

(Escherichia
coli)
PF00154
(RecA)
4 ASN A 249
PRO A 254
PHE A 255
TYR A  65
None
1.49A 5amkA-2rebA:
undetectable
5amkA-2rebA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rez MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN


(Streptomyces
glaucescens)
PF03364
(Polyketide_cyc)
4 ASN A 136
PHE A  32
TRP A  95
TYR A  97
None
1.43A 5amkA-2rezA:
undetectable
5amkA-2rezA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w61 GLYCOLIPID-ANCHORED
SURFACE PROTEIN 2


(Saccharomyces
cerevisiae)
PF03198
(Glyco_hydro_72)
PF07983
(X8)
4 ASN A 141
PRO A 145
PHE A 189
TYR A 155
None
1.39A 5amkA-2w61A:
undetectable
5amkA-2w61A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT


(Methanosarcina
mazei)
PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7)
4 PRO A 414
PHE A 416
PHE A 533
TYR A 380
None
1.24A 5amkA-2xr1A:
undetectable
5amkA-2xr1A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy7 L-THREONINE
DEHYDROGENASE


(Flavobacterium
frigidimaris)
PF01370
(Epimerase)
4 PRO A 280
PHE A 122
TRP A 279
TYR A 143
None
None
None
GOL  A1001 ( 4.1A)
1.31A 5amkA-2yy7A:
undetectable
5amkA-2yy7A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1n NDP-SUGAR EPIMERASE

(Thermoplasma
volcanium)
PF01370
(Epimerase)
4 PRO A 274
PHE A 116
TRP A 273
TYR A 137
None
None
None
NAD  A3001 (-4.2A)
1.35A 5amkA-3a1nA:
undetectable
5amkA-3a1nA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bm3 PSPGI RESTRICTION
ENDONUCLEASE


(Pyrococcus sp.
GI-H)
PF09019
(EcoRII-C)
4 ASN A 186
PHE A 256
PHE A 187
TRP A 188
None
1.41A 5amkA-3bm3A:
undetectable
5amkA-3bm3A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bm3 PSPGI RESTRICTION
ENDONUCLEASE


(Pyrococcus sp.
GI-H)
PF09019
(EcoRII-C)
4 ASN A 186
PHE A 256
PHE A 187
TYR A 213
None
1.44A 5amkA-3bm3A:
undetectable
5amkA-3bm3A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfi TYPE II SECRETORY
PATHWAY, PSEUDOPILIN
EPSJ


(Vibrio
vulnificus)
PF11612
(T2SSJ)
4 ASN B  98
PRO B  99
PHE B 103
TRP B 124
None
1.45A 5amkA-3cfiB:
undetectable
5amkA-3cfiB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxq CHOLINE/ETHANOLAMINE
KINASE FAMILY
PROTEIN


(Mesorhizobium
loti)
PF01633
(Choline_kinase)
4 ASN A 265
PHE A 270
TRP A 256
TYR A 136
None
1.38A 5amkA-3dxqA:
undetectable
5amkA-3dxqA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdc MULTICOPPER OXIDASE

(Arthrobacter
sp. FB24)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
4 ASN A  93
PRO A 124
PHE A  91
TRP A  68
None
1.40A 5amkA-3gdcA:
undetectable
5amkA-3gdcA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjj MALTOSE
O-ACETYLTRANSFERASE


(Bacillus
anthracis)
PF12464
(Mac)
PF14602
(Hexapep_2)
4 ASN A  85
PRO A 106
PHE A  83
TYR A  35
ACY  A 190 (-3.6A)
ACY  A 190 ( 4.7A)
ACY  A 190 ( 4.8A)
None
1.34A 5amkA-3hjjA:
undetectable
5amkA-3hjjA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA


(Saccharomyces
cerevisiae)
PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C)
4 ASN A 829
PRO A 828
PHE A 833
TRP A 871
None
1.10A 5amkA-3hmjA:
undetectable
5amkA-3hmjA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42


(Schizosaccharomyces
pombe)
PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV)
4 ASN A1835
PRO A1836
PHE A1842
PHE A1803
None
1.41A 5amkA-3jb9A:
undetectable
5amkA-3jb9A:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juu PORPHYRANASE B

(Zobellia
galactanivorans)
PF00722
(Glyco_hydro_16)
4 ASN A 261
PRO A 262
TRP A 260
TRP A 172
None
1.38A 5amkA-3juuA:
undetectable
5amkA-3juuA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN

(Triatoma virus)
PF08762
(CRPV_capsid)
4 ASN A  77
PRO A  78
PHE A  99
TYR A  70
None
1.36A 5amkA-3napA:
undetectable
5amkA-3napA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opw DNA
DAMAGE-RESPONSIVE
TRANSCRIPTIONAL
REPRESSOR RPH1


(Saccharomyces
cerevisiae)
PF02373
(JmjC)
PF02375
(JmjN)
4 ASN A 200
PHE A  27
TRP A  52
TYR A  21
None
1.26A 5amkA-3opwA:
undetectable
5amkA-3opwA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pe7 OLIGOGALACTURONATE
LYASE


(Yersinia
enterocolitica)
PF14583
(Pectate_lyase22)
4 PRO A 375
PHE A  84
PHE A 345
TRP A  60
None
1.31A 5amkA-3pe7A:
undetectable
5amkA-3pe7A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3som METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
C PROTEIN


(Homo sapiens)
PF16690
(MMACHC)
4 PRO A  56
PHE A 223
PHE A 154
TYR A 205
None
FLC  A 501 (-3.9A)
None
None
1.17A 5amkA-3somA:
undetectable
5amkA-3somA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE


(Streptomyces
avermitilis)
PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C)
4 PRO A 628
TRP A 347
TRP A 380
TYR A 350
None
1.23A 5amkA-3w5nA:
undetectable
5amkA-3w5nA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E


(Cupriavidus
necator)
PF01370
(Epimerase)
4 PRO A 281
PHE A 123
TRP A 280
TYR A 144
None
None
None
NAD  A 401 ( 4.4A)
1.31A 5amkA-3wmxA:
undetectable
5amkA-3wmxA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw7 GH86A
BETA-PORPHYRANASE


(Bacteroides
plebeius)
no annotation 4 ASN A 317
PRO A 274
PHE A 319
TYR A  49
None
IOD  A1704 ( 4.6A)
None
None
1.12A 5amkA-4aw7A:
undetectable
5amkA-4aw7A:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce4 MRPL38

(Sus scrofa)
no annotation 4 ASN b 191
PRO b 186
PHE b 319
TYR b 158
None
1.24A 5amkA-4ce4b:
undetectable
5amkA-4ce4b:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci2 PROTEIN CEREBLON

(Gallus gallus)
PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18)
5 ASN B 353
PRO B 354
TRP B 382
TRP B 388
TRP B 402
LVY  B1429 (-4.1A)
LVY  B1429 (-4.7A)
LVY  B1429 (-3.1A)
LVY  B1429 (-3.5A)
LVY  B1429 (-3.7A)
0.46A 5amkA-4ci2B:
16.2
5amkA-4ci2B:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbr BETA-2 ADRENERGIC
RECEPTOR


(Homo sapiens)
PF00001
(7tm_1)
4 PHE A 104
TRP A  99
TRP A 105
TRP A 109
None
1.50A 5amkA-4gbrA:
undetectable
5amkA-4gbrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hgz CCBJ

(Streptomyces
caelestis)
PF13649
(Methyltransf_25)
4 ASN A 152
PRO A 153
PHE A 239
TYR A 250
None
0.99A 5amkA-4hgzA:
undetectable
5amkA-4hgzA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmq BACTERIOPHAGE T5
DISTAL TAIL PROTEIN


(Escherichia
virus T5)
no annotation 4 ASN A   9
PRO A  10
PHE A  64
TYR A  54
None
1.43A 5amkA-4jmqA:
undetectable
5amkA-4jmqA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7a UNCHARACTERIZED
PROTEIN


(Bacteroides
caccae)
PF15890
(Peptidase_Mx1)
4 ASN A  59
PRO A  60
TRP A  52
TYR A 297
None
1.14A 5amkA-4l7aA:
undetectable
5amkA-4l7aA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqf PROTEIN RECA

(Mycobacterium
tuberculosis)
PF00154
(RecA)
4 ASN A 250
PRO A 255
PHE A 256
TYR A  66
None
None
None
EDO  A 402 (-4.8A)
1.42A 5amkA-4oqfA:
undetectable
5amkA-4oqfA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovn SODIUM CHANNEL
PROTEIN TYPE 5
SUBUNIT ALPHA


(Homo sapiens)
PF16905
(GPHH)
4 ASN F1883
PRO F1884
PHE F1879
TYR F1795
None
1.40A 5amkA-4ovnF:
undetectable
5amkA-4ovnF:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p05 ARYLSULFATE
SULFOTRANSFERASE
ASST


(Escherichia
coli)
PF05935
(Arylsulfotrans)
PF17425
(Arylsulfotran_N)
4 PHE A 231
PHE A 178
TRP A 188
TRP A 189
None
1.09A 5amkA-4p05A:
undetectable
5amkA-4p05A:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9g MBP1

(Caldanaerobius
polysaccharolyticus)
PF13416
(SBP_bac_8)
4 ASN A 391
PRO A 194
PHE A 394
TYR A 399
MAN  A 501 ( 4.9A)
None
None
None
1.44A 5amkA-4r9gA:
undetectable
5amkA-4r9gA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx8 PROBABLE CHITINASE A

(Chromobacterium
violaceum)
PF00704
(Glyco_hydro_18)
4 ASN A  94
PRO A  95
PHE A  92
TRP A 374
None
None
None
FLC  A 505 (-3.0A)
1.44A 5amkA-4tx8A:
undetectable
5amkA-4tx8A:
15.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4v30 CEREBLON ISOFORM 4

(Magnetospirillum
gryphiswaldense)
no annotation 8 ASN A  50
PRO A  51
PHE A  56
PHE A  77
TRP A  79
TRP A  85
TRP A  99
TYR A 101
LVY  A 151 (-3.8A)
LVY  A 151 (-4.4A)
None
LVY  A 151 (-4.4A)
LVY  A 151 (-3.2A)
LVY  A 151 (-3.4A)
LVY  A 151 (-3.7A)
LVY  A 151 (-4.7A)
0.56A 5amkA-4v30A:
22.2
5amkA-4v30A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wva UNCHARACTERIZED
PROTEIN


(Thermus
thermophilus)
PF01204
(Trehalase)
4 ASN A 357
PHE A  38
TRP A 418
TRP A 360
None
1.39A 5amkA-4wvaA:
undetectable
5amkA-4wvaA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yh8 SPLICING FACTOR U2AF
23 KDA SUBUNIT


(Schizosaccharomyces
pombe)
PF00076
(RRM_1)
PF00642
(zf-CCCH)
4 ASN A  60
PRO A  59
PHE A  64
TYR A  52
None
1.42A 5amkA-4yh8A:
undetectable
5amkA-4yh8A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE


(Aspergillus
flavus)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
4 ASN A 318
PHE A 414
TRP A 415
TYR A 337
LGC  A 602 ( 4.4A)
None
None
None
1.26A 5amkA-4ynuA:
undetectable
5amkA-4ynuA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5v NON-STRUCTURAL
PROTEIN 2A


(Murine
coronavirus)
PF05213
(Corona_NS2A)
4 ASN A  12
PRO A  14
PHE A  10
PHE A  13
None
1.38A 5amkA-4z5vA:
undetectable
5amkA-4z5vA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7x MDBA

(Actinomyces
oris)
PF13462
(Thioredoxin_4)
4 PHE A 135
PHE A 198
TRP A 113
TYR A 115
None
None
None
3CX  A 501 (-4.6A)
1.18A 5amkA-4z7xA:
undetectable
5amkA-4z7xA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0n PYRUVATE, PHOSPHATE
DIKINASE REGULATORY
PROTEIN,
CHLOROPLASTIC


(Zea mays)
PF03618
(Kinase-PPPase)
4 PRO A 390
PHE A 383
PHE A 337
TRP A 389
None
1.42A 5amkA-5d0nA:
undetectable
5amkA-5d0nA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dj4 SESTRIN-2

(Homo sapiens)
PF04636
(PA26)
4 PHE A 367
PHE A 401
TRP A 394
TYR A 405
None
1.30A 5amkA-5dj4A:
undetectable
5amkA-5dj4A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h05 AMYP

(marine
metagenome)
PF00128
(Alpha-amylase)
4 ASN A 148
PRO A 149
PHE A  90
TYR A  94
None
None
MLR  A 701 (-4.5A)
None
1.11A 5amkA-5h05A:
undetectable
5amkA-5h05A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb PROTEIN CEREBLON

(Homo sapiens)
no annotation 5 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
0.62A 5amkA-5hxbZ:
11.5
5amkA-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN


(Thermothelomyces
thermophila)
PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC)
4 ASN A 859
PRO A 860
PHE A 849
TYR A1112
None
1.07A 5amkA-5hzrA:
undetectable
5amkA-5hzrA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k50 L-THREONINE
3-DEHYDROGENASE


(Trypanosoma
brucei)
no annotation 4 PRO A1281
PHE A1123
TRP A1280
TYR A1144
None
None
None
GOL  A1402 ( 4.3A)
1.21A 5amkA-5k50A:
undetectable
5amkA-5k50A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kn7 LIPID A BIOSYNTHESIS
LAUROYL
ACYLTRANSFERASE


(Acinetobacter
baumannii)
PF03279
(Lip_A_acyltrans)
4 PRO B 121
PHE B 123
TRP B 126
TYR B  79
None
None
GOL  B 409 (-4.6A)
LMT  B 415 (-3.8A)
1.32A 5amkA-5kn7B:
undetectable
5amkA-5kn7B:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj6 GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN


(Bacteroides
uniformis)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF11721
(Malectin)
PF16355
(DUF4982)
4 ASN A 592
PHE A 545
TRP A 498
TYR A 553
None
1.48A 5amkA-5uj6A:
undetectable
5amkA-5uj6A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukb ANTI-VESICULAR
STOMATITIS VIRUS N
VHH


(Vicugna pacos)
no annotation 4 PRO d 105
PHE d  37
PHE d  99
TRP d 114
None
1.25A 5amkA-5ukbd:
undetectable
5amkA-5ukbd:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wjp CYCLOHEXADIENYL
DEHYDRATASE


(Candidatus
Pelagibacter
ubique)
PF00497
(SBP_bac_3)
4 ASN A 204
PRO A 205
PHE A 151
TRP A 126
None
1.49A 5amkA-5wjpA:
undetectable
5amkA-5wjpA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4s SPIKE GLYCOPROTEIN

(Severe acute
respiratory
syndrome-related
coronavirus)
PF16451
(Spike_NTD)
4 ASN A  78
PRO A  79
PHE A  76
PHE A  69
None
1.34A 5amkA-5x4sA:
undetectable
5amkA-5x4sA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6s ACETYLXYLAN ESTERASE
A


(Aspergillus
awamori)
PF10503
(Esterase_phd)
4 ASN A  13
PRO A  14
PHE A  10
TYR A 132
None
1.33A 5amkA-5x6sA:
undetectable
5amkA-5x6sA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8g 2-SUCCINYLBENZOATE--
COA LIGASE


(Bacillus
subtilis)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
4 ASN A 342
PRO A 341
PHE A 171
TYR A 209
None
1.29A 5amkA-5x8gA:
undetectable
5amkA-5x8gA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM


(Homo sapiens)
no annotation 4 ASN A 785
PRO A 786
PHE A 794
TRP A 783
None
1.50A 5amkA-5xgjA:
undetectable
5amkA-5xgjA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY


(uncultured
archaeon
MedDCM-OCT-S05-C57)
no annotation 4 PRO A 272
PHE A 115
TRP A 271
TYR A 136
None
None
AKB  A 401 (-4.5A)
AKB  A 401 (-4.5A)
1.36A 5amkA-5y1gA:
undetectable
5amkA-5y1gA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5znp SHORT LIFE FAMILY
PROTEIN


(Populus
trichocarpa)
no annotation 4 ASN A 134
PRO A 135
PHE A 124
TYR A  64
None
1.38A 5amkA-5znpA:
undetectable
5amkA-5znpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4f GLUTATHIONE
TRANSFERASE


(Trametes
versicolor)
no annotation 4 PRO A  16
PHE A 216
PHE A 168
TYR A 206
None
1.49A 5amkA-6f4fA:
undetectable
5amkA-6f4fA:
18.85