SIMILAR PATTERNS OF AMINO ACIDS FOR 5AMI_B_EF2B151_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2v METHYLAMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 ASN A 652
PRO A 653
PHE A 649
TYR A 534
 None
 1.19A 5amiB-1a2vA:
0.3		 5amiB-1a2vA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Plasmodium
falciparum) 		PF00274
(Glycolytic) 		4 ASN A 238
PRO A 237
PHE A 276
SER A 278
 None
 1.46A 5amiB-1a5cA:
0.0		 5amiB-1a5cA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Leishmania
mexicana) 		PF00274
(Glycolytic) 		4 ASN A 241
PRO A 240
PHE A 279
SER A 281
 None
 1.39A 5amiB-1epxA:
undetectable		 5amiB-1epxA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00274
(Glycolytic) 		4 ASN A 241
PRO A 240
PHE A 279
SER A 281
 None
 1.42A 5amiB-1f2jA:
0.0		 5amiB-1f2jA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fba FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Drosophila
melanogaster) 		PF00274
(Glycolytic) 		4 ASN A 231
PRO A 230
PHE A 269
SER A 271
 None
 1.43A 5amiB-1fbaA:
undetectable		 5amiB-1fbaA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7y METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2)
PF02965
(Met_synt_B12) 		4 PRO A1135
PHE A1182
SER A1183
TYR A1114
 None
 1.07A 5amiB-1k7yA:
undetectable		 5amiB-1k7yA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE

(Escherichia
coli) 		PF02965
(Met_synt_B12) 		4 PRO A1135
PHE A1182
SER A1183
TYR A1114
 SAM  A1301 (-4.5A)
None
None
None
 1.11A 5amiB-1mskA:
0.0		 5amiB-1mskA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7u ADSORPTION PROTEIN
P2

(Salmonella
virus PRD1) 		PF09214
(Prd1-P2) 		4 ASN A 321
PRO A 322
PHE A  59
SER A  61
 None
ACT  A 561 ( 4.6A)
None
None
 0.99A 5amiB-1n7uA:
0.0		 5amiB-1n7uA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o73 TRYPAREDOXIN

(Trypanosoma
brucei) 		PF13905
(Thioredoxin_8) 		4 PHE A  35
SER A  36
TRP A  86
TYR A  80
 None
 1.39A 5amiB-1o73A:
undetectable		 5amiB-1o73A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpt PROSTATIC ACID
PHOSPHATASE

(Rattus
norvegicus) 		PF00328
(His_Phos_2) 		4 ASN A 101
PRO A 102
SER A  98
TRP A 100
 None
 1.39A 5amiB-1rptA:
undetectable		 5amiB-1rptA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7g NAD-DEPENDENT
DEACETYLASE 2

(Archaeoglobus
fulgidus) 		PF02146
(SIR2) 		4 ASN A  59
PRO A  60
PHE A  56
SER A  54
 None
None
None
SO4  A 412 ( 4.5A)
 1.33A 5amiB-1s7gA:
undetectable		 5amiB-1s7gA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 ASN A 443
PRO A 444
PHE A 439
SER A 440
 2MD  A 799 (-4.5A)
None
None
2MD  A 799 ( 4.4A)
 0.65A 5amiB-1tmoA:
undetectable		 5amiB-1tmoA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukr ENDO-1,4-B-XYLANASE
I

(Aspergillus
niger) 		PF00457
(Glyco_hydro_11) 		4 ASN A  90
PRO A  91
SER A  65
TYR A  58
 None
 1.23A 5amiB-1ukrA:
undetectable		 5amiB-1ukrA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1unf IRON SUPEROXIDE
DISMUTASE

(Vigna
unguiculata) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 ASN X 178
PRO X 177
TRP X 197
TYR X  51
 None
 1.36A 5amiB-1unfX:
undetectable		 5amiB-1unfX:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		4 PRO A 289
SER A 327
TRP A 353
TRP A 399
 None
 1.34A 5amiB-1vclA:
undetectable		 5amiB-1vclA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfb ALDOLASE C

(Homo sapiens) 		PF00274
(Glycolytic) 		4 ASN A 232
PRO A 231
PHE A 270
SER A 272
 None
 1.45A 5amiB-1xfbA:
undetectable		 5amiB-1xfbA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xio ANABAENA SENSORY
RHODOPSIN

(Nostoc sp. PCC
7120) 		PF01036
(Bac_rhodopsin) 		4 PHE A 213
SER A 209
TRP A 176
TYR A 179
 None
RET  A 301 ( 4.3A)
RET  A 301 (-3.4A)
RET  A 301 (-3.5A)
 1.21A 5amiB-1xioA:
undetectable		 5amiB-1xioA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE

(Pseudomonas
stutzeri) 		PF00128
(Alpha-amylase)
PF09081
(DUF1921) 		4 ASN A 393
PRO A 394
PHE A 402
SER A 403
 None
 1.33A 5amiB-2amgA:
undetectable		 5amiB-2amgA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7l PHYCOERYTHROCYANIN
BETA CHAIN

(Mastigocladus
laminosus) 		PF00502
(Phycobilisome) 		4 ASN B  68
PRO B  69
PHE B  74
TYR B  56
 None
 1.34A 5amiB-2c7lB:
undetectable		 5amiB-2c7lB:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7t ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, HEAVY
CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 ASN H  52
PRO H  53
TRP H  50
TYR H  60
 None
 1.17A 5amiB-2d7tH:
undetectable		 5amiB-2d7tH:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Clostridium
acetobutylicum) 		PF02127
(Peptidase_M18) 		4 ASN A 116
PRO A 117
PHE A 236
SER A 238
 None
 1.38A 5amiB-2gljA:
undetectable		 5amiB-2gljA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 YDR362CP

(Saccharomyces
cerevisiae) 		no annotation 4 ASN B 495
PRO B 496
SER B 483
TYR B 526
 None
 1.14A 5amiB-2j04B:
undetectable		 5amiB-2j04B:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jl4 MALEYLPYRUVATE
ISOMERASE

(Ralstonia sp.
U2) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 PRO A  83
PHE A 156
SER A 155
TYR A 141
 None
 1.38A 5amiB-2jl4A:
undetectable		 5amiB-2jl4A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w61 GLYCOLIPID-ANCHORED
SURFACE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF03198
(Glyco_hydro_72)
PF07983
(X8) 		4 ASN A 141
PRO A 145
PHE A 189
TYR A 155
 None
 1.32A 5amiB-2w61A:
undetectable		 5amiB-2w61A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wrd HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ASN A 243
PHE A 244
SER A 246
TYR A 200
 None
 1.27A 5amiB-2wrdA:
undetectable		 5amiB-2wrdA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3h K5 LYASE

(Escherichia
virus K1-5) 		no annotation 4 ASN A  70
PHE A  96
SER A 124
TYR A 151
 None
 1.38A 5amiB-2x3hA:
undetectable		 5amiB-2x3hA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy7 L-THREONINE
DEHYDROGENASE

(Flavobacterium
frigidimaris) 		PF01370
(Epimerase) 		4 PRO A 280
PHE A 122
TRP A 279
TYR A 143
 None
None
None
GOL  A1001 ( 4.1A)
 1.43A 5amiB-2yy7A:
undetectable		 5amiB-2yy7A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 ASN A 459
PRO A 458
SER A 301
TRP A 302
 None
 1.37A 5amiB-3a24A:
undetectable		 5amiB-3a24A:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale) 		PF00232
(Glyco_hydro_1) 		4 ASN A 190
PHE A 187
TRP A 144
TYR A 168
 None
 1.38A 5amiB-3aivA:
undetectable		 5amiB-3aivA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bma D-ALANYL-LIPOTEICHOI
C ACID SYNTHETASE

(Streptococcus
pneumoniae) 		PF04914
(DltD) 		4 ASN A 319
PRO A 320
PHE A 313
SER A 314
 None
 1.35A 5amiB-3bmaA:
undetectable		 5amiB-3bmaA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bv4 FRUCTOSE-BISPHOSPHAT
E ALDOLASE A

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		4 ASN A 231
PRO A 230
PHE A 269
SER A 271
 None
None
None
13P  A3371 (-3.1A)
 1.42A 5amiB-3bv4A:
undetectable		 5amiB-3bv4A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 ASN A1048
SER A1066
TRP A1053
TYR A1060
 None
 1.36A 5amiB-3ecqA:
undetectable		 5amiB-3ecqA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1w MANNOSE-6-PHOSPHATE
ISOMERASE

(Salmonella
enterica) 		PF01238
(PMI_typeI) 		4 PRO A 305
PHE A 314
SER A 324
TYR A 388
 None
 1.27A 5amiB-3h1wA:
undetectable		 5amiB-3h1wA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvn HEMOLYSIN

(Streptococcus
suis) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 ASN A  34
PRO A 238
PHE A  37
SER A  39
 None
 1.32A 5amiB-3hvnA:
undetectable		 5amiB-3hvnA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j26 CAPSID PROTEIN V20

(Mimivirus-dependent
virus Sputnik) 		no annotation 4 PRO A 102
PHE A  98
SER A 243
TYR A 157
 None
 1.05A 5amiB-3j26A:
undetectable		 5amiB-3j26A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juu PORPHYRANASE B

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		4 ASN A 261
PRO A 262
TRP A 260
TRP A 172
 None
 1.40A 5amiB-3juuA:
undetectable		 5amiB-3juuA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kie CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 PRO A 308
PHE A 638
TRP A 619
TYR A 352
 None
 1.43A 5amiB-3kieA:
undetectable		 5amiB-3kieA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Babesia bovis) 		PF00274
(Glycolytic) 		4 ASN A 230
PRO A 229
PHE A 268
SER A 270
 None
None
None
CIT  A 400 (-3.4A)
 1.37A 5amiB-3kx6A:
undetectable		 5amiB-3kx6A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln3 DIHYDRODIOL
DEHYDROGENASE

(Mus musculus) 		PF00248
(Aldo_ket_red) 		4 ASN A 127
PRO A 130
TRP A  86
TYR A  53
 None
MLY  A 123 ( 4.7A)
None
MLY  A 105 ( 3.5A)
 1.38A 5amiB-3ln3A:
undetectable		 5amiB-3ln3A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4f ENDO-1,4-BETA-XYLANA
SE

(Acidomyces
acidophilus) 		PF00457
(Glyco_hydro_11) 		4 ASN A 113
PRO A 114
SER A  88
TYR A  81
 None
 1.32A 5amiB-3m4fA:
undetectable		 5amiB-3m4fA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		4 ASN A 225
PRO A 224
PHE A 262
SER A 264
 None
None
None
2FP  A 350 (-2.3A)
 1.44A 5amiB-3mmtA:
undetectable		 5amiB-3mmtA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN

(Triatoma virus) 		PF08762
(CRPV_capsid) 		4 ASN A  77
PRO A  78
PHE A  99
TYR A  70
 None
 1.43A 5amiB-3napA:
undetectable		 5amiB-3napA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng9 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 PRO A 309
PHE A 638
TRP A 619
TYR A 353
 None
 1.44A 5amiB-3ng9A:
undetectable		 5amiB-3ng9A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE

(Cytophaga
hutchinsonii) 		PF01494
(FAD_binding_3) 		4 PRO A  50
PHE A  89
TRP A  99
TRP A 101
 None
 1.17A 5amiB-3nixA:
undetectable		 5amiB-3nixA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Francisella
tularensis) 		PF00342
(PGI) 		4 ASN A  46
PHE A  32
SER A  33
TYR A  40
 None
 1.38A 5amiB-3q88A:
undetectable		 5amiB-3q88A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ra2 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 PRO A 311
PHE A 640
TRP A 621
TYR A 355
 None
 1.39A 5amiB-3ra2A:
undetectable		 5amiB-3ra2A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfy CRYPTOCOCCUS
NEOFORMANS PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT

(Cryptococcus
neoformans) 		PF01239
(PPTA) 		4 PRO A 127
PHE A 158
SER A 156
TYR A 195
 None
 1.27A 5amiB-3sfyA:
undetectable		 5amiB-3sfyA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sp1 CYSTEINYL-TRNA
SYNTHETASE

(Borreliella
burgdorferi) 		PF01406
(tRNA-synt_1e) 		4 PRO A 215
SER A 124
TRP A 206
TYR A  95
 None
 1.29A 5amiB-3sp1A:
undetectable		 5amiB-3sp1A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up8 PUTATIVE
2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE B

(Sinorhizobium
meliloti) 		PF00248
(Aldo_ket_red) 		4 PRO A 271
SER A 135
TRP A 106
TYR A 183
 None
None
None
ACT  A 276 (-3.7A)
 1.39A 5amiB-3up8A:
undetectable		 5amiB-3up8A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usc HYDROGENASE-1 LARGE
CHAIN

(Escherichia
coli) 		PF00374
(NiFeSe_Hases) 		4 ASN L 375
PRO L 376
SER L 396
TRP L 397
 None
 1.30A 5amiB-3uscL:
undetectable		 5amiB-3uscL:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux1 CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 PRO A 310
PHE A 638
TRP A 619
TYR A 354
 None
 1.43A 5amiB-3ux1A:
undetectable		 5amiB-3ux1A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm7 ALPHA-AMYLASE

(Malbranchea
cinnamomea) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		4 ASN A 158
PRO A 159
PHE A 160
SER A 162
 None
None
None
NAG  A 502 ( 4.7A)
 1.26A 5amiB-3vm7A:
undetectable		 5amiB-3vm7A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vom PUTATIVE
PHOSPHOSERINE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		4 PHE A 112
SER A 109
TRP A 149
TYR A 105
 None
 1.38A 5amiB-3vomA:
undetectable		 5amiB-3vomA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waj TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Archaeoglobus
fulgidus) 		PF02516
(STT3) 		4 ASN A 160
PHE A 159
SER A 155
TRP A 165
 None
 1.34A 5amiB-3wajA:
undetectable		 5amiB-3wajA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whe IMMUNOGLOBULIN HEAVY
CHAIN

(Homo sapiens) 		no annotation 4 SER M  35
TRP M  47
TRP M  50
TYR M 111
 None
 1.26A 5amiB-3wheM:
undetectable		 5amiB-3wheM:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Cupriavidus
necator) 		PF01370
(Epimerase) 		4 PRO A 281
PHE A 123
TRP A 280
TYR A 144
 None
None
None
NAD  A 401 ( 4.4A)
 1.41A 5amiB-3wmxA:
undetectable		 5amiB-3wmxA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo0 ALANINE-ANTICAPSIN
LIGASE BACD

(Bacillus
subtilis) 		PF13535
(ATP-grasp_4) 		4 PRO A  35
PHE A  33
SER A  32
TYR A  21
 None
 1.22A 5amiB-3wo0A:
undetectable		 5amiB-3wo0A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 ASN A 126
PHE A 129
SER A 193
TYR A 540
 ZN  A1595 ( 2.7A)
None
A12  A1598 ( 4.7A)
A12  A1598 (-3.4A)
 1.02A 5amiB-3zu0A:
undetectable		 5amiB-3zu0A:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION

(Staphylothermus
marinus) 		PF00128
(Alpha-amylase) 		4 ASN A 338
PRO A 339
PHE A 344
TYR A 423
 None
 1.17A 5amiB-4aeeA:
undetectable		 5amiB-4aeeA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 ASN A 270
PRO A 271
PHE A 453
SER A 454
 None
 1.10A 5amiB-4arxA:
undetectable		 5amiB-4arxA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw7 GH86A
BETA-PORPHYRANASE

(Bacteroides
plebeius) 		no annotation 4 ASN A 317
PRO A 274
PHE A 319
TYR A  49
 None
IOD  A1704 ( 4.6A)
None
None
 0.97A 5amiB-4aw7A:
undetectable		 5amiB-4aw7A:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxw FACTOR XA

(Pseudonaja
textilis) 		PF00089
(Trypsin)
PF14670
(FXa_inhibition) 		4 ASN A 135
PRO A 182
SER A 131
TYR A 115
 None
 1.34A 5amiB-4bxwA:
undetectable		 5amiB-4bxwA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		6 ASN B 353
PRO B 354
SER B 381
TRP B 382
TRP B 388
TRP B 402
 LVY  B1429 (-4.1A)
LVY  B1429 (-4.7A)
LVY  B1429 (-3.8A)
LVY  B1429 (-3.1A)
LVY  B1429 (-3.5A)
LVY  B1429 (-3.7A)
 0.39A 5amiB-4ci2B:
16.4		 5amiB-4ci2B:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Toxoplasma
gondii) 		PF00274
(Glycolytic) 		4 ASN A 303
PRO A 302
PHE A 341
SER A 343
 None
None
None
SO4  A1418 ( 3.9A)
 1.39A 5amiB-4d2jA:
undetectable		 5amiB-4d2jA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iov CAPSID PROTEIN VP1

(Adeno-associated
virus) 		PF00740
(Parvo_coat) 		4 PRO A 299
PHE A 635
TRP A 616
TYR A 343
 None
 1.41A 5amiB-4iovA:
undetectable		 5amiB-4iovA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iss ALLOPHANATE
HYDROLASE

(Kluyveromyces
lactis) 		PF01425
(Amidase) 		4 PRO A 244
PHE A 435
SER A 436
TYR A 251
 None
 1.27A 5amiB-4issA:
undetectable		 5amiB-4issA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 PRO A  69
PHE A  70
TRP A 350
TYR A 930
 None
 1.38A 5amiB-4iugA:
undetectable		 5amiB-4iugA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqf PROTEIN RECA

(Mycobacterium
tuberculosis) 		PF00154
(RecA) 		4 ASN A 250
PRO A 255
PHE A 256
TYR A  66
 None
None
None
EDO  A 402 (-4.8A)
 1.40A 5amiB-4oqfA:
undetectable		 5amiB-4oqfA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ot1 SM5-1 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASN H  52
PRO H  53
TRP H  50
TYR H  60
 None
 1.20A 5amiB-4ot1H:
undetectable		 5amiB-4ot1H:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhq LIPOPROTEIN

(Burkholderia
cenocepacia) 		PF03180
(Lipoprotein_9) 		4 ASN A 204
PHE A  85
SER A  84
TYR A 250
 MET  A 301 (-4.3A)
MET  A 301 (-4.7A)
None
None
 1.20A 5amiB-4qhqA:
undetectable		 5amiB-4qhqA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rso CAPSID PROTEIN VP1

(Non-human
primate
Adeno-associated
virus) 		PF00740
(Parvo_coat) 		4 PRO A 310
PHE A 638
TRP A 619
TYR A 354
 None
 1.45A 5amiB-4rsoA:
undetectable		 5amiB-4rsoA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tl3 ANABAENA SENSORY
RHODOPSIN

(Nostoc sp. PCC
7120) 		PF01036
(Bac_rhodopsin) 		4 PHE A 213
SER A 209
TRP A 176
TYR A 179
 None
RET  A 301 ( 4.1A)
RET  A 301 (-3.8A)
RET  A 301 (-3.3A)
 1.29A 5amiB-4tl3A:
undetectable		 5amiB-4tl3A:
18.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tzc PROTEIN CEREBLON

(Mus musculus) 		no annotation 4 SER C 381
TRP C 382
TRP C 388
TRP C 402
 EF2  C 502 (-4.1A)
EF2  C 502 ( 3.2A)
EF2  C 502 (-3.5A)
EF2  C 502 (-3.8A)
 0.27A 5amiB-4tzcC:
15.9		 5amiB-4tzcC:
33.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4v30 CEREBLON ISOFORM 4

(Magnetospirillum
gryphiswaldense) 		no annotation 8 ASN A  50
PRO A  51
PHE A  77
SER A  78
TRP A  79
TRP A  85
TRP A  99
TYR A 101
 LVY  A 151 (-3.8A)
LVY  A 151 (-4.4A)
LVY  A 151 (-4.4A)
LVY  A 151 (-4.0A)
LVY  A 151 (-3.2A)
LVY  A 151 (-3.4A)
LVY  A 151 (-3.7A)
LVY  A 151 (-4.7A)
 0.26A 5amiB-4v30A:
22.3		 5amiB-4v30A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkq NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Staphylococcus
aureus) 		PF00496
(SBP_bac_5) 		4 ASN A 436
PRO A 435
SER A 278
TYR A 441
 None
 1.33A 5amiB-4xkqA:
undetectable		 5amiB-4xkqA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xtl SODIUM PUMPING
RHODOPSIN

(Dokdonia
eikasta) 		PF01036
(Bac_rhodopsin) 		4 ASN A  81
SER A  29
TRP A  82
TYR A  25
 None
None
None
NA  A 301 (-4.7A)
 1.43A 5amiB-4xtlA:
undetectable		 5amiB-4xtlA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE

(Aspergillus
flavus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 ASN A 318
PHE A 414
TRP A 415
TYR A 337
 LGC  A 602 ( 4.4A)
None
None
None
 1.32A 5amiB-4ynuA:
undetectable		 5amiB-4ynuA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7x MDBA

(Actinomyces
oris) 		PF13462
(Thioredoxin_4) 		4 ASN A 200
PHE A 198
SER A 195
TYR A 115
 None
None
3CX  A 501 (-3.4A)
3CX  A 501 (-4.6A)
 1.09A 5amiB-4z7xA:
undetectable		 5amiB-4z7xA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 ASN A1048
SER A1066
TRP A1053
TYR A1060
 None
 1.27A 5amiB-5a55A:
undetectable		 5amiB-5a55A:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czw MYROILYSIN

(Myroides
profundi) 		PF01400
(Astacin) 		4 ASN A 219
PRO A 162
PHE A 221
SER A 214
 None
 1.36A 5amiB-5czwA:
undetectable		 5amiB-5czwA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g47 SFTSV GC

(SFTS
phlebovirus) 		PF07245
(Phlebovirus_G2) 		4 PHE A 707
SER A 646
TRP A 708
TRP A 673
 None
 1.36A 5amiB-5g47A:
undetectable		 5amiB-5g47A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hd2 PARASPORAL CRYSTAL
PROTEIN

(Bacillus
thuringiensis) 		PF03318
(ETX_MTX2) 		4 PHE A 225
SER A 222
TRP A 223
TYR A 203
 None
 1.41A 5amiB-5hd2A:
undetectable		 5amiB-5hd2A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqb ALPHA-GLUCOSIDASE

(Pseudoalteromonas
sp. K8) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 ASN A 469
PRO A 468
SER A 278
TRP A 279
 None
 1.33A 5amiB-5hqbA:
undetectable		 5amiB-5hqbA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb PROTEIN CEREBLON

(Homo sapiens) 		no annotation 6 ASN Z 351
PRO Z 352
SER Z 379
TRP Z 380
TRP Z 386
TRP Z 400
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
 0.47A 5amiB-5hxbZ:
11.6		 5amiB-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 PRO A  69
PHE A  70
TRP A 350
TYR A 932
 None
 1.41A 5amiB-5ihrA:
undetectable		 5amiB-5ihrA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy6 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT

(Homo sapiens) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		4 ASN V 539
PRO V 538
PHE V 703
SER V 704
 None
 1.45A 5amiB-5iy6V:
undetectable		 5amiB-5iy6V:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k50 L-THREONINE
3-DEHYDROGENASE

(Trypanosoma
brucei) 		no annotation 4 PRO A1281
PHE A1123
TRP A1280
TYR A1144
 None
None
None
GOL  A1402 ( 4.3A)
 1.31A 5amiB-5k50A:
undetectable		 5amiB-5k50A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koh NITROGENASE FEMO
BETA SUBUNIT PROTEIN
NIFK

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 ASN B 440
PRO B 460
PHE B 459
TYR B 313
 None
 1.30A 5amiB-5kohB:
undetectable		 5amiB-5kohB:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3w PEPTIDE CYCLASE 1

(Gypsophila
vaccaria) 		no annotation 4 ASN A 683
PRO A 684
PHE A   6
SER A   7
 None
 1.36A 5amiB-5o3wA:
undetectable		 5amiB-5o3wA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT,XPB,TFIIH
BASAL TRANSCRIPTION
FACTOR COMPLEX
HELICASE XPB SUBUNIT

(Homo sapiens) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		4 ASN A 539
PRO A 538
PHE A 703
SER A 704
 None
 1.38A 5amiB-5of4A:
undetectable		 5amiB-5of4A:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5pep PEPSIN

(Sus scrofa) 		PF00026
(Asp) 		4 ASN A  57
PRO A  58
PHE A  64
SER A  62
 None
 1.37A 5amiB-5pepA:
undetectable		 5amiB-5pepA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		4 ASN A 389
PRO A 390
SER A 338
TRP A 387
 None
 1.12A 5amiB-5svcA:
undetectable		 5amiB-5svcA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 4 ASN B 304
PRO B 273
PHE B 301
TYR B  74
 None
 1.43A 5amiB-5swiB:
undetectable		 5amiB-5swiB:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj3 ALKALINE PHOSPHATASE
PAFA

(Elizabethkingia
meningoseptica) 		PF01663
(Phosphodiest) 		4 PRO A 169
PHE A  87
SER A  85
TYR A  74
 None
 1.23A 5amiB-5tj3A:
undetectable		 5amiB-5tj3A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN

(Geobacillus sp.
Y4.1MC1) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF13193
(AMP-binding_C) 		4 PRO A1379
PHE A1058
SER A1057
TYR A1219
 None
 1.20A 5amiB-5u89A:
undetectable		 5amiB-5u89A:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY

(uncultured
archaeon
MedDCM-OCT-S05-C57) 		no annotation 4 PRO A 272
PHE A 115
TRP A 271
TYR A 136
 None
None
AKB  A 401 (-4.5A)
AKB  A 401 (-4.5A)
 1.45A 5amiB-5y1gA:
undetectable		 5amiB-5y1gA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yow GLYCOPROTEIN
POLYPROTEIN

(Heartland virus) 		no annotation 4 PHE A 145
SER A  84
TRP A 146
TRP A 111
 None
 1.43A 5amiB-5yowA:
undetectable		 5amiB-5yowA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a0z HEMAGGLUTININ,ENVELO
PE GLYCOPROTEIN

(Human
immunodeficiency
virus 1;
Influenza A
virus) 		no annotation 4 ASN A 244
PHE A 245
SER A 247
TYR A 201
 None
 1.22A 5amiB-6a0zA:
undetectable		 5amiB-6a0zA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN
S7E

(Leishmania
donovani) 		no annotation 4 ASN I 191
PRO I 192
SER I 198
TRP I 190
 None
None
U  11361 ( 3.7A)
U  11361 ( 3.6A)
 1.36A 5amiB-6az1I:
undetectable		 5amiB-6az1I:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwf NITRIC-OXIDE
REDUCTASE

(Neisseria
meningitidis) 		no annotation 4 ASN A 229
PRO A 225
PHE A 622
SER A 620
 None
 1.14A 5amiB-6fwfA:
undetectable		 5amiB-6fwfA:
24.60