SIMILAR PATTERNS OF AMINO ACIDS FOR 5AMI_A_EF2A151_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2v METHYLAMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 ASN A 652
PRO A 653
PHE A 649
TYR A 534
 None
 1.22A 5amiA-1a2vA:
undetectable		 5amiA-1a2vA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bru ELASTASE

(Sus scrofa) 		PF00089
(Trypsin) 		4 ASN P 200
PRO P 198
TRP P  27
TRP P 207
 None
 1.46A 5amiA-1bruP:
undetectable		 5amiA-1bruP:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1unf IRON SUPEROXIDE
DISMUTASE

(Vigna
unguiculata) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 ASN X 178
PRO X 177
TRP X 197
TYR X  51
 None
 1.34A 5amiA-1unfX:
0.0		 5amiA-1unfX:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		4 PRO A 229
PHE A 228
TRP A 155
TYR A 157
 None
 1.48A 5amiA-1ygpA:
0.0		 5amiA-1ygpA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7l PHYCOERYTHROCYANIN
BETA CHAIN

(Mastigocladus
laminosus) 		PF00502
(Phycobilisome) 		4 ASN B  68
PRO B  69
PHE B  74
TYR B  56
 None
 1.34A 5amiA-2c7lB:
undetectable		 5amiA-2c7lB:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7t ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, HEAVY
CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 ASN H  52
PRO H  53
TRP H  50
TYR H  60
 None
 1.16A 5amiA-2d7tH:
0.0		 5amiA-2d7tH:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8g CAPSID

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 PRO A 299
PHE A 636
TRP A 617
TYR A 343
 None
 1.45A 5amiA-2g8gA:
undetectable		 5amiA-2g8gA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w61 GLYCOLIPID-ANCHORED
SURFACE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF03198
(Glyco_hydro_72)
PF07983
(X8) 		4 ASN A 141
PRO A 145
PHE A 189
TYR A 155
 None
 1.30A 5amiA-2w61A:
0.0		 5amiA-2w61A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1

(Arabidopsis
thaliana) 		PF07859
(Abhydrolase_3) 		4 ASN A 264
PRO A 265
PHE A 221
TRP A 294
 None
 1.48A 5amiA-2zsiA:
0.0		 5amiA-2zsiA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale) 		PF00232
(Glyco_hydro_1) 		4 ASN A 190
PHE A 187
TRP A 144
TYR A 168
 None
 1.40A 5amiA-3aivA:
0.0		 5amiA-3aivA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4p CAPSID PROTEIN VP1

(Adeno-associated
virus) 		PF00740
(Parvo_coat) 		4 PRO A 310
PHE A 639
TRP A 620
TYR A 354
 None
 1.46A 5amiA-3j4pA:
undetectable		 5amiA-3j4pA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juu PORPHYRANASE B

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		4 ASN A 261
PRO A 262
TRP A 260
TRP A 172
 None
 1.49A 5amiA-3juuA:
undetectable		 5amiA-3juuA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kie CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 PRO A 308
PHE A 638
TRP A 619
TYR A 352
 None
 1.41A 5amiA-3kieA:
undetectable		 5amiA-3kieA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln3 DIHYDRODIOL
DEHYDROGENASE

(Mus musculus) 		PF00248
(Aldo_ket_red) 		4 ASN A 127
PRO A 130
TRP A  86
TYR A  53
 None
MLY  A 123 ( 4.7A)
None
MLY  A 105 ( 3.5A)
 1.35A 5amiA-3ln3A:
undetectable		 5amiA-3ln3A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng9 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 PRO A 309
PHE A 638
TRP A 619
TYR A 353
 None
 1.42A 5amiA-3ng9A:
undetectable		 5amiA-3ng9A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE

(Cytophaga
hutchinsonii) 		PF01494
(FAD_binding_3) 		4 PRO A  50
PHE A  89
TRP A  99
TRP A 101
 None
 1.15A 5amiA-3nixA:
undetectable		 5amiA-3nixA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntt CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
B) 		PF00740
(Parvo_coat) 		4 PRO A 299
PHE A 627
TRP A 608
TYR A 343
 None
 1.48A 5amiA-3nttA:
undetectable		 5amiA-3nttA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ra2 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 PRO A 311
PHE A 640
TRP A 621
TYR A 355
 None
 1.37A 5amiA-3ra2A:
undetectable		 5amiA-3ra2A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shm CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 PRO A 309
PHE A 638
TRP A 619
TYR A 353
 None
 1.43A 5amiA-3shmA:
undetectable		 5amiA-3shmA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux1 CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 PRO A 310
PHE A 638
TRP A 619
TYR A 354
 None
 1.41A 5amiA-3ux1A:
undetectable		 5amiA-3ux1A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 PRO A 628
TRP A 347
TRP A 380
TYR A 350
 None
 1.28A 5amiA-3w5nA:
undetectable		 5amiA-3w5nA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Cupriavidus
necator) 		PF01370
(Epimerase) 		4 PRO A 281
PHE A 123
TRP A 280
TYR A 144
 None
None
None
NAD  A 401 ( 4.4A)
 1.48A 5amiA-3wmxA:
undetectable		 5amiA-3wmxA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION

(Staphylothermus
marinus) 		PF00128
(Alpha-amylase) 		4 ASN A 338
PRO A 339
PHE A 344
TYR A 423
 None
 1.18A 5amiA-4aeeA:
undetectable		 5amiA-4aeeA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw7 GH86A
BETA-PORPHYRANASE

(Bacteroides
plebeius) 		no annotation 4 ASN A 317
PRO A 274
PHE A 319
TYR A  49
 None
IOD  A1704 ( 4.6A)
None
None
 0.98A 5amiA-4aw7A:
undetectable		 5amiA-4aw7A:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		5 ASN B 353
PRO B 354
TRP B 382
TRP B 388
TRP B 402
 LVY  B1429 (-4.1A)
LVY  B1429 (-4.7A)
LVY  B1429 (-3.1A)
LVY  B1429 (-3.5A)
LVY  B1429 (-3.7A)
 0.43A 5amiA-4ci2B:
16.2		 5amiA-4ci2B:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkl ALPHA-AMYLASE

(Thermotoga
neapolitana) 		PF00128
(Alpha-amylase) 		4 PRO A 284
PHE A 278
TRP A 353
TYR A 351
 None
 1.46A 5amiA-4gklA:
undetectable		 5amiA-4gklA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iov CAPSID PROTEIN VP1

(Adeno-associated
virus) 		PF00740
(Parvo_coat) 		4 PRO A 299
PHE A 635
TRP A 616
TYR A 343
 None
 1.40A 5amiA-4iovA:
undetectable		 5amiA-4iovA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 PRO A  69
PHE A  70
TRP A 350
TYR A 930
 None
 1.40A 5amiA-4iugA:
undetectable		 5amiA-4iugA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqf PROTEIN RECA

(Mycobacterium
tuberculosis) 		PF00154
(RecA) 		4 ASN A 250
PRO A 255
PHE A 256
TYR A  66
 None
None
None
EDO  A 402 (-4.8A)
 1.39A 5amiA-4oqfA:
undetectable		 5amiA-4oqfA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ot1 SM5-1 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASN H  52
PRO H  53
TRP H  50
TYR H  60
 None
 1.20A 5amiA-4ot1H:
undetectable		 5amiA-4ot1H:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rso CAPSID PROTEIN VP1

(Non-human
primate
Adeno-associated
virus) 		PF00740
(Parvo_coat) 		4 PRO A 310
PHE A 638
TRP A 619
TYR A 354
 None
 1.44A 5amiA-4rsoA:
undetectable		 5amiA-4rsoA:
12.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4v30 CEREBLON ISOFORM 4

(Magnetospirillum
gryphiswaldense) 		no annotation 7 ASN A  50
PRO A  51
PHE A  77
TRP A  79
TRP A  85
TRP A  99
TYR A 101
 LVY  A 151 (-3.8A)
LVY  A 151 (-4.4A)
LVY  A 151 (-4.4A)
LVY  A 151 (-3.2A)
LVY  A 151 (-3.4A)
LVY  A 151 (-3.7A)
LVY  A 151 (-4.7A)
 0.14A 5amiA-4v30A:
23.6		 5amiA-4v30A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE

(Aspergillus
flavus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 ASN A 318
PHE A 414
TRP A 415
TYR A 337
 LGC  A 602 ( 4.4A)
None
None
None
 1.43A 5amiA-4ynuA:
undetectable		 5amiA-4ynuA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb PROTEIN CEREBLON

(Homo sapiens) 		no annotation 5 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
 0.49A 5amiA-5hxbZ:
11.5		 5amiA-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 PRO A  69
PHE A  70
TRP A 350
TYR A 932
 None
 1.43A 5amiA-5ihrA:
undetectable		 5amiA-5ihrA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k50 L-THREONINE
3-DEHYDROGENASE

(Trypanosoma
brucei) 		no annotation 4 PRO A1281
PHE A1123
TRP A1280
TYR A1144
 None
None
None
GOL  A1402 ( 4.3A)
 1.39A 5amiA-5k50A:
undetectable		 5amiA-5k50A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koh NITROGENASE FEMO
BETA SUBUNIT PROTEIN
NIFK

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 ASN B 440
PRO B 460
PHE B 459
TYR B 313
 None
 1.35A 5amiA-5kohB:
undetectable		 5amiA-5kohB:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 4 ASN B 304
PRO B 273
PHE B 301
TYR B  74
 None
 1.45A 5amiA-5swiB:
undetectable		 5amiA-5swiB:
11.60