SIMILAR PATTERNS OF AMINO ACIDS FOR 5ALC_L_TIQL1210_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a33 PEPTIDYLPROLYL
ISOMERASE


(Brugia malayi)
PF00160
(Pro_isomerase)
4 SER A 145
GLY A 146
ILE A 170
GLY A  21
None
0.81A 5alcL-1a33A:
undetectable
5alcL-1a33A:
19.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b4j ANTIBODY

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 SER L  34
TYR L  36
GLY L  89
PHE L  98
None
0.35A 5alcL-1b4jL:
15.5
5alcL-1b4jL:
43.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN


(Homo sapiens)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 SER A 213
GLY A 210
ILE A 172
GLY A 181
None
0.76A 5alcL-1d1tA:
undetectable
5alcL-1d1tA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA


(Methanosarcina
barkeri)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
4 TYR A1328
GLY A1324
ILE A1316
GLY A1510
None
0.84A 5alcL-1e6yA:
undetectable
5alcL-1e6yA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idu VANADIUM
CHLOROPEROXIDASE


(Curvularia
inaequalis)
PF01569
(PAP2)
4 TYR A 304
GLY A 408
ILE A 507
PHE A 412
None
0.74A 5alcL-1iduA:
undetectable
5alcL-1iduA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE


(Pyrococcus
horikoshii)
PF00291
(PALP)
4 SER A 191
GLY A 193
ILE A  55
GLY A 163
PLP  A 401 (-2.6A)
PLP  A 401 (-3.6A)
None
None
0.81A 5alcL-1j0aA:
undetectable
5alcL-1j0aA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE


(Thermus
thermophilus)
PF01293
(PEPCK_ATP)
4 SER A 391
GLY A 395
SER A 218
PHE A 398
None
0.83A 5alcL-1j3bA:
undetectable
5alcL-1j3bA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN


(Salmonella
enterica)
PF00654
(Voltage_CLC)
4 SER A 350
TYR A  94
GLY A 351
GLY A 354
None
0.74A 5alcL-1kplA:
undetectable
5alcL-1kplA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ms8 TRANS-SIALIDASE

(Trypanosoma
cruzi)
PF13385
(Laminin_G_3)
PF13859
(BNR_3)
4 GLY A 587
SER A 592
GLY A 460
PHE A 455
None
0.74A 5alcL-1ms8A:
undetectable
5alcL-1ms8A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npc NEUTRAL PROTEASE

(Bacillus cereus)
PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
4 GLY A 224
ILE A 237
SER A 235
GLY A 230
None
0.80A 5alcL-1npcA:
undetectable
5alcL-1npcA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE


(Geobacillus
stearothermophilus)
PF01676
(Metalloenzyme)
PF06415
(iPGM_N)
4 SER A 118
GLY A 120
ILE A  82
SER A  78
None
0.78A 5alcL-1o99A:
undetectable
5alcL-1o99A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfw ANTIBODY (ANTI BETA
SUBUNIT) (LIGHT
CHAIN)


(Mus musculus)
PF07686
(V-set)
4 SER M 234
TYR M 236
GLY M 289
PHE M 298
None
0.49A 5alcL-1qfwM:
17.7
5alcL-1qfwM:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuf DIAMINOPIMELATE
DECARBOXYLASE


(Methanocaldococcus
jannaschii)
PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N)
4 TYR A 401
GLY A 306
ILE A 302
GLY A 263
AZ1  A 502 ( 4.1A)
LLP  A  83 ( 3.0A)
None
LLP  A  83 ( 3.9A)
0.86A 5alcL-1tufA:
undetectable
5alcL-1tufA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]


(Archaeoglobus
fulgidus)
PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C)
4 GLY A 204
ILE A 273
SER A 272
GLY A 270
None
0.85A 5alcL-1txgA:
undetectable
5alcL-1txgA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyp BETA-FRUCTOSIDASE

(Thermotoga
maritima)
PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C)
4 SER A  77
GLY A  76
ILE A 189
SER A 154
None
0.74A 5alcL-1uypA:
undetectable
5alcL-1uypA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf1 GLUTATHIONE
S-TRANSFERASE 3


(Gallus gallus)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 TYR A 223
ILE A  19
SER A  18
GLY A  14
None
0.82A 5alcL-1vf1A:
undetectable
5alcL-1vf1A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vme FLAVOPROTEIN

(Thermotoga
maritima)
PF00258
(Flavodoxin_1)
4 SER A  91
TYR A 121
GLY A  92
ILE A  25
None
0.86A 5alcL-1vmeA:
undetectable
5alcL-1vmeA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl6 BOTULINUM NEUROTOXIN
TYPE E


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
4 TYR A 278
GLY A 176
ILE A 180
GLY A 219
None
0.81A 5alcL-1zl6A:
undetectable
5alcL-1zl6A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ej9 PUTATIVE BIOTIN
LIGASE


(Methanocaldococcus
jannaschii)
PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB)
4 SER A  11
GLY A  37
ILE A 110
GLY A  39
BTN  A1301 (-2.6A)
BTN  A1301 (-3.4A)
None
BTN  A1301 (-3.3A)
0.85A 5alcL-2ej9A:
undetectable
5alcL-2ej9A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvt CONSERVED
HYPOTHETICAL PROTEIN


(Rhodopseudomonas
palustris)
PF04430
(DUF498)
4 TYR A  19
GLY A  23
GLY A  33
PHE A  24
None
0.77A 5alcL-2fvtA:
undetectable
5alcL-2fvtA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg5 FRUCTOSE 1-PHOSPHATE
KINASE


(Staphylococcus
aureus)
PF00294
(PfkB)
4 SER A  10
GLY A  36
SER A 247
PHE A  34
None
0.84A 5alcL-2jg5A:
undetectable
5alcL-2jg5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2npm 14-3-3 DOMAIN
CONTAINING PROTEIN


(Cryptosporidium
parvum)
PF00244
(14-3-3)
4 SER A 160
ILE A 127
GLY A 153
PHE A 206
None
0.82A 5alcL-2npmA:
undetectable
5alcL-2npmA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pby GLUTAMINASE

(Geobacillus
kaustophilus)
PF04960
(Glutaminase)
4 GLY A 265
ILE A 256
GLY A 277
PHE A 279
None
0.80A 5alcL-2pbyA:
undetectable
5alcL-2pbyA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pig PUTATIVE TRANSFERASE

(Salmonella
enterica)
no annotation 4 TYR A 211
ILE A 289
SER A 290
GLY A 254
None
0.85A 5alcL-2pigA:
undetectable
5alcL-2pigA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl5 HOMOSERINE
O-ACETYLTRANSFERASE


(Leptospira
interrogans)
PF00561
(Abhydrolase_1)
4 TYR A 208
GLY A 119
ILE A  98
SER A 104
None
0.83A 5alcL-2pl5A:
undetectable
5alcL-2pl5A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rau PUTATIVE ESTERASE

(Sulfolobus
solfataricus)
PF12146
(Hydrolase_4)
4 GLY A  57
ILE A 173
GLY A 154
PHE A 152
UNL  A 359 ( 4.1A)
None
None
None
0.83A 5alcL-2rauA:
undetectable
5alcL-2rauA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA


(Desulfovibrio
vulgaris)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
4 SER A 167
GLY A  78
ILE A 152
GLY A  72
None
0.63A 5alcL-2v4jA:
undetectable
5alcL-2v4jA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y1l DARPIN-8.4

(synthetic
construct)
PF12796
(Ank_2)
PF13637
(Ank_4)
4 GLY E  91
ILE E 152
SER E 153
GLY E 124
None
0.85A 5alcL-2y1lE:
undetectable
5alcL-2y1lE:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE


(Thermus
thermophilus)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 GLY A 158
ILE A 186
SER A 191
GLY A 183
None
0.77A 5alcL-3aoeA:
undetectable
5alcL-3aoeA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brz TODX

(Pseudomonas
putida)
PF03349
(Toluene_X)
4 GLY A 218
ILE A 139
SER A 154
GLY A 220
None
0.71A 5alcL-3brzA:
undetectable
5alcL-3brzA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fo8 TAIL SHEATH PROTEIN
GP18


(Escherichia
virus T4)
PF17481
(Phage_sheath_1N)
4 SER D 191
GLY D 342
ILE D 236
GLY D 231
None
0.81A 5alcL-3fo8D:
undetectable
5alcL-3fo8D:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9k CAPSULE BIOSYNTHESIS
PROTEIN CAPD


(Bacillus
anthracis)
no annotation 4 SER S 367
GLY L  98
ILE L  93
GLY L 135
None
0.82A 5alcL-3g9kS:
undetectable
5alcL-3g9kS:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbu SECRETED PROTEASE C

(Dickeya
chrysanthemi)
PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C)
4 SER P 275
GLY P 272
ILE P 334
SER P 333
None
0.85A 5alcL-3hbuP:
undetectable
5alcL-3hbuP:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42


(Schizosaccharomyces
pombe)
PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV)
4 TYR A1298
GLY A1216
ILE A1115
PHE A1217
None
0.81A 5alcL-3jb9A:
undetectable
5alcL-3jb9A:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq4 CUBILIN

(Homo sapiens)
PF00431
(CUB)
4 SER B1189
TRP B1193
ILE B1257
GLY B1166
None
0.80A 5alcL-3kq4B:
undetectable
5alcL-3kq4B:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll3 GLUCONATE KINASE

(Lactobacillus
acidophilus)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
4 TYR A 476
GLY A 373
ILE A 299
SER A 260
None
0.71A 5alcL-3ll3A:
undetectable
5alcL-3ll3A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odp PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE


(Clostridium
novyi)
PF01380
(SIS)
4 GLY A 242
ILE A 316
GLY A 236
PHE A 241
None
0.85A 5alcL-3odpA:
undetectable
5alcL-3odpA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT ALPHA


(Desulfovibrio
gigas)
PF01077
(NIR_SIR)
4 SER A 167
GLY A  78
ILE A 152
GLY A  72
None
0.64A 5alcL-3or2A:
undetectable
5alcL-3or2A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5


(Thermotoga
petrophila)
PF00150
(Cellulase)
4 GLY A 108
ILE A 102
GLY A  97
PHE A 109
None
0.86A 5alcL-3pz9A:
undetectable
5alcL-3pz9A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sns LIPOPROTEIN 34

(Escherichia
coli)
PF06804
(Lipoprotein_18)
4 SER A 314
GLY A 308
SER A 269
GLY A 274
None
None
CL  A   3 ( 4.5A)
None
0.79A 5alcL-3snsA:
undetectable
5alcL-3snsA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umf ADENYLATE KINASE

(Schistosoma
mansoni)
PF00406
(ADK)
4 SER A  20
GLY A  16
ILE A  12
GLY A  95
None
0.84A 5alcL-3umfA:
undetectable
5alcL-3umfA:
19.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wlw ANTIBODY L CHAIN

(Homo sapiens)
no annotation 4 SER L  36
TYR L  38
SER L  97
PHE L 101
None
0.77A 5alcL-3wlwL:
21.0
5alcL-3wlwL:
53.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE


(Streptomyces
coelicolor)
PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5)
4 SER A  91
TYR A  84
ILE A 247
GLY A 256
None
0.65A 5alcL-3zgjA:
undetectable
5alcL-3zgjA:
21.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zl4 A17 ANTIBODY FAB
FRAGMENT LAMBDA
LIGHT CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 SER L  35
TYR L  37
GLY L  90
PHE L 100
MES  L1217 ( 3.9A)
None
None
MES  L1217 ( 4.9A)
0.55A 5alcL-3zl4L:
26.4
5alcL-3zl4L:
94.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b52 BACILLOLYSIN

(Paenibacillus
polymyxa)
PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
4 GLY A 211
ILE A 224
SER A 222
GLY A 217
None
0.83A 5alcL-4b52A:
undetectable
5alcL-4b52A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be9 STEROL ESTERASE

(Ophiostoma
piceae)
PF00135
(COesterase)
4 SER A 225
GLY A 222
ILE A 313
GLY A 134
None
None
1PE  A1553 (-4.7A)
PGE  A1554 ( 4.7A)
0.86A 5alcL-4be9A:
undetectable
5alcL-4be9A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buh CLONE M0418 SCFV

(Homo sapiens)
PF07686
(V-set)
4 TYR A 178
TRP A 233
GLY A 240
PHE A 242
None
0.50A 5alcL-4buhA:
22.6
5alcL-4buhA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxm ERPC

(Borreliella
burgdorferi)
PF02471
(OspE)
4 TYR A 146
GLY A 133
SER A  96
PHE A 131
None
0.84A 5alcL-4bxmA:
undetectable
5alcL-4bxmA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1b ORF1-ENCODED PROTEIN

(Danio rerio)
PF13472
(Lipase_GDSL_2)
4 SER A 184
GLY A 180
ILE A 171
SER A 172
None
0.85A 5alcL-4c1bA:
undetectable
5alcL-4c1bA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa)
PF01979
(Amidohydro_1)
4 SER A 275
GLY A 251
ILE A 207
GLY A 248
None
0.83A 5alcL-4dykA:
undetectable
5alcL-4dykA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6o METACASPASE-1

(Saccharomyces
cerevisiae)
PF00656
(Peptidase_C14)
4 SER A 382
GLY A 379
ILE A 143
GLY A 154
None
0.69A 5alcL-4f6oA:
undetectable
5alcL-4f6oA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU


(Yersinia pestis)
PF01032
(FecCD)
4 SER A  93
GLY A  88
ILE A  75
GLY A 261
None
0.52A 5alcL-4g1uA:
undetectable
5alcL-4g1uA:
19.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4glr ANTI-PTAU LIGHT
CHAIN


(Gallus gallus)
PF07654
(C1-set)
PF07686
(V-set)
4 TYR I  36
GLY I  89
GLY I  96
PHE I  98
None
0.31A 5alcL-4glrI:
24.5
5alcL-4glrI:
78.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1l TETANUS TOXIN

(Clostridium
tetani)
PF01742
(Peptidase_M27)
4 TYR A 299
GLY A 189
ILE A 193
GLY A 241
None
0.83A 5alcL-4j1lA:
undetectable
5alcL-4j1lA:
20.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 LIGHT
CHAIN


(Oryctolagus
cuniculus)
PF07654
(C1-set)
PF07686
(V-set)
4 TYR L  92
GLY L  90
ILE L  21
GLY L  99
None
0.85A 5alcL-4jo2L:
21.3
5alcL-4jo2L:
42.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgu STRUCTURAL PROTEIN
VP2


(Orthopteran
ambidensovirus
1)
PF02336
(Denso_VP4)
4 TYR A 181
ILE A  72
SER A  74
GLY A  76
None
0.82A 5alcL-4mguA:
undetectable
5alcL-4mguA:
20.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mwf FAB AR3C HEAVY CHAIN

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 SER A  95
TYR A  32
TRP A  47
GLY A  50
None
0.81A 5alcL-4mwfA:
14.5
5alcL-4mwfA:
30.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p49 ANTIBODY SCFV B8

(Gallus gallus)
PF07686
(V-set)
4 TYR A  30
GLY A  84
GLY A  91
PHE A  93
None
0.23A 5alcL-4p49A:
18.5
5alcL-4p49A:
38.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2h PROLINE RACEMASE
PROTEIN


(Agrobacterium
tumefaciens)
PF05544
(Pro_racemase)
4 SER A 149
GLY A 173
ILE A 239
GLY A 256
None
None
GOL  A 402 ( 4.8A)
CSO  A 255 (-2.4A)
0.66A 5alcL-4q2hA:
undetectable
5alcL-4q2hA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rep GAMMA-CAROTENE
DESATURASE


(Nonlabens
dokdonensis)
PF01593
(Amino_oxidase)
4 GLY A 460
ILE A 226
SER A 227
GLY A  10
FAD  A 501 ( 3.7A)
None
None
FAD  A 501 (-3.4A)
0.86A 5alcL-4repA:
undetectable
5alcL-4repA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN


(Haemophilus
influenzae)
PF05860
(Haemagg_act)
4 SER A 385
GLY A 412
ILE A 437
GLY A 442
None
0.85A 5alcL-4rt6A:
undetectable
5alcL-4rt6A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd3 L-AMINO ACID LIGASE

(Bacillus
subtilis)
PF13535
(ATP-grasp_4)
4 GLY A 233
ILE A 295
GLY A 328
PHE A 330
None
0.79A 5alcL-4wd3A:
undetectable
5alcL-4wd3A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE


(Mycobacterium
tuberculosis)
PF01467
(CTP_transf_like)
4 GLY A  10
ILE A 161
SER A 133
GLY A 107
None
0.62A 5alcL-4x0eA:
undetectable
5alcL-4x0eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xat NOELIN

(Homo sapiens)
PF02191
(OLF)
4 SER A 242
GLY A 243
ILE A 449
GLY A 247
None
0.73A 5alcL-4xatA:
undetectable
5alcL-4xatA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybr NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE


(Mycobacterium
tuberculosis)
PF01467
(CTP_transf_like)
4 GLY A  10
ILE A 161
SER A 133
GLY A 107
NAP  A 301 (-3.1A)
None
None
NAP  A 301 (-3.1A)
0.76A 5alcL-4ybrA:
undetectable
5alcL-4ybrA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N)
4 TYR A 279
GLY A 177
ILE A 181
GLY A 220
None
0.68A 5alcL-4zktA:
undetectable
5alcL-4zktA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3y THERMOLYSIN

(Bacillus
thermoproteolyticus)
PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
4 GLY A 223
ILE A 236
SER A 234
GLY A 229
None
0.83A 5alcL-5a3yA:
undetectable
5alcL-5a3yA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amo NOELIN

(Mus musculus)
PF02191
(OLF)
4 SER A 242
GLY A 243
ILE A 449
GLY A 247
None
0.71A 5alcL-5amoA:
undetectable
5alcL-5amoA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnn CAPSID PROTEIN VP2

(Enterovirus D)
PF00073
(Rhv)
4 GLY B 133
ILE B 167
SER B 166
GLY B 164
None
0.86A 5alcL-5bnnB:
undetectable
5alcL-5bnnB:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)


(Clostridium
acetobutylicum)
PF02055
(Glyco_hydro_30)
4 TYR A 115
ILE A 203
SER A 202
PHE A 161
None
0.84A 5alcL-5cxpA:
undetectable
5alcL-5cxpA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dd4 TRANSCRIPTIONAL
REGULATOR ARAR


(Bacteroides
thetaiotaomicron)
PF00293
(NUDIX)
4 GLY A  14
ILE A  18
GLY A  47
PHE A  49
None
0.61A 5alcL-5dd4A:
undetectable
5alcL-5dd4A:
22.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fcs DIABODY

(Homo sapiens)
PF07686
(V-set)
4 GLY L  90
TRP L  92
SER L  97
PHE L 101
None
0.82A 5alcL-5fcsL:
22.8
5alcL-5fcsL:
52.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fcu JR4 FAB LIGHT CHAIN

(Macaca mulatta)
PF07654
(C1-set)
PF07686
(V-set)
5 SER L  34
TYR L  36
GLY L  89
TRP L  91
PHE L  98
None
0.40A 5alcL-5fcuL:
19.0
5alcL-5fcuL:
84.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxn THERMOLYSIN

(Bacillus
thermoproteolyticus)
PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
4 GLY A 223
ILE A 236
SER A 234
GLY A 229
None
0.83A 5alcL-5fxnA:
undetectable
5alcL-5fxnA:
21.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grj AVELUMAB L CHAIN

(Homo sapiens)
PF07686
(V-set)
4 SER L  36
TYR L  38
SER L  97
PHE L 101
None
0.69A 5alcL-5grjL:
20.5
5alcL-5grjL:
65.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN


(Chaetomium
thermophilum)
PF03178
(CPSF_A)
PF10433
(MMS1_N)
4 SER A 886
GLY A 904
SER A 916
GLY A 919
None
None
CA  A1302 (-2.2A)
None
0.57A 5alcL-5hy7A:
undetectable
5alcL-5hy7A:
11.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i8o HMM5 ANTIBODY LIGHT
CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 TYR L  94
GLY L  92
ILE L  21
GLY L 102
None
0.83A 5alcL-5i8oL:
21.4
5alcL-5i8oL:
44.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icl LIPOATE--PROTEIN
LIGASE


(Enterococcus
faecalis)
PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C)
4 GLY A 283
ILE A  42
GLY A  71
PHE A 285
None
LAQ  A 401 ( 4.1A)
None
None
0.67A 5alcL-5iclA:
undetectable
5alcL-5iclA:
18.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ilt BOVINE FAB A01 LIGHT
CHAIN


(Bos taurus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER L  34
TYR L  36
SER L  94
PHE L  98
None
0.64A 5alcL-5iltL:
26.0
5alcL-5iltL:
67.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jz7 MEDI578 SCFV, LIGHT
CHAIN


(Homo sapiens)
PF07686
(V-set)
4 TYR D  36
GLY D  89
TRP D  91
PHE D  98
None
0.64A 5alcL-5jz7D:
21.9
5alcL-5jz7D:
57.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT


(Aromatoleum
aromaticum)
PF02538
(Hydantoinase_B)
4 SER A  66
GLY A  83
ILE A 419
GLY A 444
None
0.75A 5alcL-5l9wA:
undetectable
5alcL-5l9wA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lae PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE
OXIDASE,PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE OXIDASE


(Mus musculus)
PF01593
(Amino_oxidase)
4 SER A 381
GLY A 378
ILE A 183
GLY A 189
None
0.84A 5alcL-5laeA:
undetectable
5alcL-5laeA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mje NANOBODY 8

(Lama glama)
PF07686
(V-set)
4 SER B   9
GLY B  10
ILE B  71
SER B  70
None
0.84A 5alcL-5mjeB:
13.8
5alcL-5mjeB:
18.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ngv ANTI-HUMAN ACTRIIB
MAB BYM338
LIGHT-CHAIN


(Homo sapiens)
no annotation 4 TYR L  38
GLY L  91
GLY L 100
PHE L 102
None
0.27A 5alcL-5ngvL:
20.3
5alcL-5ngvL:
37.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS


(Erwinia
amylovora)
no annotation 4 GLY A  10
ILE A   5
GLY A  32
PHE A  34
None
0.52A 5alcL-5o8rA:
undetectable
5alcL-5o8rA:
16.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN


(Homo sapiens)
no annotation 4 SER L  35
TRP L  92
SER L  97
PHE L 101
None
0.59A 5alcL-5ocyL:
18.6
5alcL-5ocyL:
72.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t87 CDII IMMUNITY
PROTEIN


(Cupriavidus
taiwanensis)
no annotation 4 SER A  22
GLY A  23
ILE A  35
SER A  34
None
0.82A 5alcL-5t87A:
undetectable
5alcL-5t87A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9g GLYCOSIDE HYDROLASE

(Bacteroides
uniformis)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982)
4 GLY A 317
ILE A 564
GLY A 571
PHE A 573
None
0.86A 5alcL-5t9gA:
6.0
5alcL-5t9gA:
14.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u0r DH270.UCA1 LIGHT
CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 SER L  36
TYR L  38
SER L  97
PHE L 101
None
0.76A 5alcL-5u0rL:
17.9
5alcL-5u0rL:
82.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ukn DH522UCA FAB
FRAGMENT LIGHT CHAIN


(Macaca mulatta)
no annotation 4 SER L  34
TYR L  36
GLY L  89
PHE L  98
None
0.29A 5alcL-5uknL:
26.8
5alcL-5uknL:
68.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voh NADH OXIDASE

(Lactobacillus
brevis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 SER A 280
GLY A 278
ILE A  16
GLY A 304
None
FAD  A 501 (-3.0A)
None
None
0.81A 5alcL-5vohA:
undetectable
5alcL-5vohA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxb PROXP-ALA

(Caulobacter
vibrioides)
PF04073
(tRNA_edit)
4 SER A 124
GLY A  42
ILE A  59
GLY A  63
None
0.84A 5alcL-5vxbA:
undetectable
5alcL-5vxbA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wjc KINETOCHORE PROTEIN
MIS16


(Schizosaccharomyces
pombe)
no annotation 4 GLY A 154
ILE A 225
SER A 226
GLY A 180
None
0.85A 5alcL-5wjcA:
undetectable
5alcL-5wjcA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wua ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL
11,SUPERFOLDER GFP


(Mus musculus;
synthetic
construct)
PF01007
(IRK)
4 GLY A 132
ILE A 114
SER A 113
GLY A 135
None
0.83A 5alcL-5wuaA:
3.6
5alcL-5wuaA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9r CITRATE-SODIUM
SYMPORTER


(Klebsiella
pneumoniae)
PF03390
(2HCT)
4 GLY A 380
ILE A 157
SER A 156
GLY A 151
None
0.78A 5alcL-5x9rA:
undetectable
5alcL-5x9rA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bvd LIGHT CHAIN

(Clostridium
botulinum)
no annotation 4 TYR A 292
GLY A 186
ILE A 190
GLY A 234
None
0.85A 5alcL-6bvdA:
undetectable
5alcL-6bvdA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN


(Theobroma cacao)
no annotation 4 SER A 464
GLY A 465
ILE A 399
SER A 397
None
0.82A 5alcL-6cthA:
undetectable
5alcL-6cthA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED


(Escherichia
coli;
Xenopus laevis)
no annotation 4 SER A 504
GLY A 502
ILE A 493
PHE A 247
None
0.83A 5alcL-6d35A:
undetectable
5alcL-6d35A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3


(Homo sapiens)
no annotation 4 SER A 639
GLY A 668
SER A 696
GLY A 672
None
0.84A 5alcL-6en4A:
undetectable
5alcL-6en4A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epd PROTEASOME SUBUNIT
BETA TYPE-6


(Rattus
norvegicus)
no annotation 4 SER 1 166
TYR 1 167
GLY 1 164
GLY 1 130
None
0.86A 5alcL-6epd1:
undetectable
5alcL-6epd1:
18.72