SIMILAR PATTERNS OF AMINO ACIDS FOR 5ALC_L_TIQL1210_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a33 | PEPTIDYLPROLYLISOMERASE (Brugia malayi) |
PF00160(Pro_isomerase) | 4 | SER A 145GLY A 146ILE A 170GLY A 21 | None | 0.81A | 5alcL-1a33A:undetectable | 5alcL-1a33A:19.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1b4j | ANTIBODY (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | SER L 34TYR L 36GLY L 89PHE L 98 | None | 0.35A | 5alcL-1b4jL:15.5 | 5alcL-1b4jL:43.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d1t | ALCOHOLDEHYDROGENASE CLASSIV SIGMA CHAIN (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | SER A 213GLY A 210ILE A 172GLY A 181 | None | 0.76A | 5alcL-1d1tA:undetectable | 5alcL-1d1tA:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e6y | METHYL-COENZYME MREDUCTASE SUBUNITALPHA (Methanosarcinabarkeri) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N) | 4 | TYR A1328GLY A1324ILE A1316GLY A1510 | None | 0.84A | 5alcL-1e6yA:undetectable | 5alcL-1e6yA:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1idu | VANADIUMCHLOROPEROXIDASE (Curvulariainaequalis) |
PF01569(PAP2) | 4 | TYR A 304GLY A 408ILE A 507PHE A 412 | None | 0.74A | 5alcL-1iduA:undetectable | 5alcL-1iduA:15.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j0a | 1-AMINOCYCLOPROPANE-1-CARBOXYLATEDEAMINASE (Pyrococcushorikoshii) |
PF00291(PALP) | 4 | SER A 191GLY A 193ILE A 55GLY A 163 | PLP A 401 (-2.6A)PLP A 401 (-3.6A)NoneNone | 0.81A | 5alcL-1j0aA:undetectable | 5alcL-1j0aA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j3b | ATP-DEPENDENTPHOSPHOENOLPYRUVATECARBOXYKINASE (Thermusthermophilus) |
PF01293(PEPCK_ATP) | 4 | SER A 391GLY A 395SER A 218PHE A 398 | None | 0.83A | 5alcL-1j3bA:undetectable | 5alcL-1j3bA:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kpl | PUTATIVE CLC FAMILY,CHLORINE TRANSPORTPROTEIN (Salmonellaenterica) |
PF00654(Voltage_CLC) | 4 | SER A 350TYR A 94GLY A 351GLY A 354 | None | 0.74A | 5alcL-1kplA:undetectable | 5alcL-1kplA:17.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ms8 | TRANS-SIALIDASE (Trypanosomacruzi) |
PF13385(Laminin_G_3)PF13859(BNR_3) | 4 | GLY A 587SER A 592GLY A 460PHE A 455 | None | 0.74A | 5alcL-1ms8A:undetectable | 5alcL-1ms8A:18.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1npc | NEUTRAL PROTEASE (Bacillus cereus) |
PF01447(Peptidase_M4)PF02868(Peptidase_M4_C) | 4 | GLY A 224ILE A 237SER A 235GLY A 230 | None | 0.80A | 5alcL-1npcA:undetectable | 5alcL-1npcA:23.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o99 | 2,3-BISPHOSPHOGLYCERATE-INDEPENDENTPHOSPHOGLYCERATEMUTASE (Geobacillusstearothermophilus) |
PF01676(Metalloenzyme)PF06415(iPGM_N) | 4 | SER A 118GLY A 120ILE A 82SER A 78 | None | 0.78A | 5alcL-1o99A:undetectable | 5alcL-1o99A:15.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qfw | ANTIBODY (ANTI BETASUBUNIT) (LIGHTCHAIN) (Mus musculus) |
PF07686(V-set) | 4 | SER M 234TYR M 236GLY M 289PHE M 298 | None | 0.49A | 5alcL-1qfwM:17.7 | 5alcL-1qfwM:28.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tuf | DIAMINOPIMELATEDECARBOXYLASE (Methanocaldococcusjannaschii) |
PF00278(Orn_DAP_Arg_deC)PF02784(Orn_Arg_deC_N) | 4 | TYR A 401GLY A 306ILE A 302GLY A 263 | AZ1 A 502 ( 4.1A)LLP A 83 ( 3.0A)NoneLLP A 83 ( 3.9A) | 0.86A | 5alcL-1tufA:undetectable | 5alcL-1tufA:16.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1txg | GLYCEROL-3-PHOSPHATEDEHYDROGENASE[NAD(P)+] (Archaeoglobusfulgidus) |
PF01210(NAD_Gly3P_dh_N)PF07479(NAD_Gly3P_dh_C) | 4 | GLY A 204ILE A 273SER A 272GLY A 270 | None | 0.85A | 5alcL-1txgA:undetectable | 5alcL-1txgA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uyp | BETA-FRUCTOSIDASE (Thermotogamaritima) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 4 | SER A 77GLY A 76ILE A 189SER A 154 | None | 0.74A | 5alcL-1uypA:undetectable | 5alcL-1uypA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vf1 | GLUTATHIONES-TRANSFERASE 3 (Gallus gallus) |
PF02798(GST_N)PF14497(GST_C_3) | 4 | TYR A 223ILE A 19SER A 18GLY A 14 | None | 0.82A | 5alcL-1vf1A:undetectable | 5alcL-1vf1A:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vme | FLAVOPROTEIN (Thermotogamaritima) |
PF00258(Flavodoxin_1) | 4 | SER A 91TYR A 121GLY A 92ILE A 25 | None | 0.86A | 5alcL-1vmeA:undetectable | 5alcL-1vmeA:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zl6 | BOTULINUM NEUROTOXINTYPE E (Clostridiumbotulinum) |
PF01742(Peptidase_M27) | 4 | TYR A 278GLY A 176ILE A 180GLY A 219 | None | 0.81A | 5alcL-1zl6A:undetectable | 5alcL-1zl6A:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ej9 | PUTATIVE BIOTINLIGASE (Methanocaldococcusjannaschii) |
PF02237(BPL_C)PF03099(BPL_LplA_LipB) | 4 | SER A 11GLY A 37ILE A 110GLY A 39 | BTN A1301 (-2.6A)BTN A1301 (-3.4A)NoneBTN A1301 (-3.3A) | 0.85A | 5alcL-2ej9A:undetectable | 5alcL-2ej9A:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fvt | CONSERVEDHYPOTHETICAL PROTEIN (Rhodopseudomonaspalustris) |
PF04430(DUF498) | 4 | TYR A 19GLY A 23GLY A 33PHE A 24 | None | 0.77A | 5alcL-2fvtA:undetectable | 5alcL-2fvtA:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jg5 | FRUCTOSE 1-PHOSPHATEKINASE (Staphylococcusaureus) |
PF00294(PfkB) | 4 | SER A 10GLY A 36SER A 247PHE A 34 | None | 0.84A | 5alcL-2jg5A:undetectable | 5alcL-2jg5A:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2npm | 14-3-3 DOMAINCONTAINING PROTEIN (Cryptosporidiumparvum) |
PF00244(14-3-3) | 4 | SER A 160ILE A 127GLY A 153PHE A 206 | None | 0.82A | 5alcL-2npmA:undetectable | 5alcL-2npmA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pby | GLUTAMINASE (Geobacilluskaustophilus) |
PF04960(Glutaminase) | 4 | GLY A 265ILE A 256GLY A 277PHE A 279 | None | 0.80A | 5alcL-2pbyA:undetectable | 5alcL-2pbyA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pig | PUTATIVE TRANSFERASE (Salmonellaenterica) |
no annotation | 4 | TYR A 211ILE A 289SER A 290GLY A 254 | None | 0.85A | 5alcL-2pigA:undetectable | 5alcL-2pigA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pl5 | HOMOSERINEO-ACETYLTRANSFERASE (Leptospirainterrogans) |
PF00561(Abhydrolase_1) | 4 | TYR A 208GLY A 119ILE A 98SER A 104 | None | 0.83A | 5alcL-2pl5A:undetectable | 5alcL-2pl5A:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rau | PUTATIVE ESTERASE (Sulfolobussolfataricus) |
PF12146(Hydrolase_4) | 4 | GLY A 57ILE A 173GLY A 154PHE A 152 | UNL A 359 ( 4.1A)NoneNoneNone | 0.83A | 5alcL-2rauA:undetectable | 5alcL-2rauA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v4j | SULFITE REDUCTASE,DISSIMILATORY-TYPESUBUNIT ALPHA (Desulfovibriovulgaris) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 4 | SER A 167GLY A 78ILE A 152GLY A 72 | None | 0.63A | 5alcL-2v4jA:undetectable | 5alcL-2v4jA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y1l | DARPIN-8.4 (syntheticconstruct) |
PF12796(Ank_2)PF13637(Ank_4) | 4 | GLY E 91ILE E 152SER E 153GLY E 124 | None | 0.85A | 5alcL-2y1lE:undetectable | 5alcL-2y1lE:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aoe | GLUTAMATEDEHYDROGENASE (Thermusthermophilus) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 4 | GLY A 158ILE A 186SER A 191GLY A 183 | None | 0.77A | 5alcL-3aoeA:undetectable | 5alcL-3aoeA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3brz | TODX (Pseudomonasputida) |
PF03349(Toluene_X) | 4 | GLY A 218ILE A 139SER A 154GLY A 220 | None | 0.71A | 5alcL-3brzA:undetectable | 5alcL-3brzA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fo8 | TAIL SHEATH PROTEINGP18 (Escherichiavirus T4) |
PF17481(Phage_sheath_1N) | 4 | SER D 191GLY D 342ILE D 236GLY D 231 | None | 0.81A | 5alcL-3fo8D:undetectable | 5alcL-3fo8D:25.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g9k | CAPSULE BIOSYNTHESISPROTEIN CAPD (Bacillusanthracis) |
no annotation | 4 | SER S 367GLY L 98ILE L 93GLY L 135 | None | 0.82A | 5alcL-3g9kS:undetectable | 5alcL-3g9kS:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hbu | SECRETED PROTEASE C (Dickeyachrysanthemi) |
PF00353(HemolysinCabind)PF00413(Peptidase_M10)PF08548(Peptidase_M10_C) | 4 | SER P 275GLY P 272ILE P 334SER P 333 | None | 0.85A | 5alcL-3hbuP:undetectable | 5alcL-3hbuP:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | PRE-MRNA-SPLICINGFACTOR SPP42 (Schizosaccharomycespombe) |
PF08082(PRO8NT)PF08083(PROCN)PF10596(U6-snRNA_bdg)PF10597(U5_2-snRNA_bdg)PF10598(RRM_4)PF12134(PRP8_domainIV) | 4 | TYR A1298GLY A1216ILE A1115PHE A1217 | None | 0.81A | 5alcL-3jb9A:undetectable | 5alcL-3jb9A:6.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kq4 | CUBILIN (Homo sapiens) |
PF00431(CUB) | 4 | SER B1189TRP B1193ILE B1257GLY B1166 | None | 0.80A | 5alcL-3kq4B:undetectable | 5alcL-3kq4B:17.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ll3 | GLUCONATE KINASE (Lactobacillusacidophilus) |
PF00370(FGGY_N)PF02782(FGGY_C) | 4 | TYR A 476GLY A 373ILE A 299SER A 260 | None | 0.71A | 5alcL-3ll3A:undetectable | 5alcL-3ll3A:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3odp | PUTATIVETAGATOSE-6-PHOSPHATEKETOSE/ALDOSEISOMERASE (Clostridiumnovyi) |
PF01380(SIS) | 4 | GLY A 242ILE A 316GLY A 236PHE A 241 | None | 0.85A | 5alcL-3odpA:undetectable | 5alcL-3odpA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3or2 | SULFITE REDCUTASESUBUNIT ALPHA (Desulfovibriogigas) |
PF01077(NIR_SIR) | 4 | SER A 167GLY A 78ILE A 152GLY A 72 | None | 0.64A | 5alcL-3or2A:undetectable | 5alcL-3or2A:17.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pz9 | MANNANENDO-1,4-BETA-MANNOSIDASE. GLYCOSYLHYDROLASE FAMILY 5 (Thermotogapetrophila) |
PF00150(Cellulase) | 4 | GLY A 108ILE A 102GLY A 97PHE A 109 | None | 0.86A | 5alcL-3pz9A:undetectable | 5alcL-3pz9A:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sns | LIPOPROTEIN 34 (Escherichiacoli) |
PF06804(Lipoprotein_18) | 4 | SER A 314GLY A 308SER A 269GLY A 274 | NoneNone CL A 3 ( 4.5A)None | 0.79A | 5alcL-3snsA:undetectable | 5alcL-3snsA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3umf | ADENYLATE KINASE (Schistosomamansoni) |
PF00406(ADK) | 4 | SER A 20GLY A 16ILE A 12GLY A 95 | None | 0.84A | 5alcL-3umfA:undetectable | 5alcL-3umfA:19.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3wlw | ANTIBODY L CHAIN (Homo sapiens) |
no annotation | 4 | SER L 36TYR L 38SER L 97PHE L 101 | None | 0.77A | 5alcL-3wlwL:21.0 | 5alcL-3wlwL:53.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zgj | 4-HYDROXYPHENYLPYRUVIC ACID DIOXYGENASE (Streptomycescoelicolor) |
PF00903(Glyoxalase)PF14696(Glyoxalase_5) | 4 | SER A 91TYR A 84ILE A 247GLY A 256 | None | 0.65A | 5alcL-3zgjA:undetectable | 5alcL-3zgjA:21.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zl4 | A17 ANTIBODY FABFRAGMENT LAMBDALIGHT CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | SER L 35TYR L 37GLY L 90PHE L 100 | MES L1217 ( 3.9A)NoneNoneMES L1217 ( 4.9A) | 0.55A | 5alcL-3zl4L:26.4 | 5alcL-3zl4L:94.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b52 | BACILLOLYSIN (Paenibacilluspolymyxa) |
PF01447(Peptidase_M4)PF02868(Peptidase_M4_C) | 4 | GLY A 211ILE A 224SER A 222GLY A 217 | None | 0.83A | 5alcL-4b52A:undetectable | 5alcL-4b52A:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4be9 | STEROL ESTERASE (Ophiostomapiceae) |
PF00135(COesterase) | 4 | SER A 225GLY A 222ILE A 313GLY A 134 | NoneNone1PE A1553 (-4.7A)PGE A1554 ( 4.7A) | 0.86A | 5alcL-4be9A:undetectable | 5alcL-4be9A:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4buh | CLONE M0418 SCFV (Homo sapiens) |
PF07686(V-set) | 4 | TYR A 178TRP A 233GLY A 240PHE A 242 | None | 0.50A | 5alcL-4buhA:22.6 | 5alcL-4buhA:26.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bxm | ERPC (Borreliellaburgdorferi) |
PF02471(OspE) | 4 | TYR A 146GLY A 133SER A 96PHE A 131 | None | 0.84A | 5alcL-4bxmA:undetectable | 5alcL-4bxmA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c1b | ORF1-ENCODED PROTEIN (Danio rerio) |
PF13472(Lipase_GDSL_2) | 4 | SER A 184GLY A 180ILE A 171SER A 172 | None | 0.85A | 5alcL-4c1bA:undetectable | 5alcL-4c1bA:24.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dyk | AMIDOHYDROLASE (Pseudomonasaeruginosa) |
PF01979(Amidohydro_1) | 4 | SER A 275GLY A 251ILE A 207GLY A 248 | None | 0.83A | 5alcL-4dykA:undetectable | 5alcL-4dykA:18.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f6o | METACASPASE-1 (Saccharomycescerevisiae) |
PF00656(Peptidase_C14) | 4 | SER A 382GLY A 379ILE A 143GLY A 154 | None | 0.69A | 5alcL-4f6oA:undetectable | 5alcL-4f6oA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g1u | HEMIN TRANSPORTSYSTEM PERMEASEPROTEIN HMUU (Yersinia pestis) |
PF01032(FecCD) | 4 | SER A 93GLY A 88ILE A 75GLY A 261 | None | 0.52A | 5alcL-4g1uA:undetectable | 5alcL-4g1uA:19.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4glr | ANTI-PTAU LIGHTCHAIN (Gallus gallus) |
PF07654(C1-set)PF07686(V-set) | 4 | TYR I 36GLY I 89GLY I 96PHE I 98 | None | 0.31A | 5alcL-4glrI:24.5 | 5alcL-4glrI:78.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j1l | TETANUS TOXIN (Clostridiumtetani) |
PF01742(Peptidase_M27) | 4 | TYR A 299GLY A 189ILE A 193GLY A 241 | None | 0.83A | 5alcL-4j1lA:undetectable | 5alcL-4j1lA:20.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4jo2 | MONOCLONALANTI-HIV-1 GP120 V3ANTIBODY R56 LIGHTCHAIN (Oryctolaguscuniculus) |
PF07654(C1-set)PF07686(V-set) | 4 | TYR L 92GLY L 90ILE L 21GLY L 99 | None | 0.85A | 5alcL-4jo2L:21.3 | 5alcL-4jo2L:42.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mgu | STRUCTURAL PROTEINVP2 (Orthopteranambidensovirus1) |
PF02336(Denso_VP4) | 4 | TYR A 181ILE A 72SER A 74GLY A 76 | None | 0.82A | 5alcL-4mguA:undetectable | 5alcL-4mguA:20.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4mwf | FAB AR3C HEAVY CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | SER A 95TYR A 32TRP A 47GLY A 50 | None | 0.81A | 5alcL-4mwfA:14.5 | 5alcL-4mwfA:30.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4p49 | ANTIBODY SCFV B8 (Gallus gallus) |
PF07686(V-set) | 4 | TYR A 30GLY A 84GLY A 91PHE A 93 | None | 0.23A | 5alcL-4p49A:18.5 | 5alcL-4p49A:38.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q2h | PROLINE RACEMASEPROTEIN (Agrobacteriumtumefaciens) |
PF05544(Pro_racemase) | 4 | SER A 149GLY A 173ILE A 239GLY A 256 | NoneNoneGOL A 402 ( 4.8A)CSO A 255 (-2.4A) | 0.66A | 5alcL-4q2hA:undetectable | 5alcL-4q2hA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rep | GAMMA-CAROTENEDESATURASE (Nonlabensdokdonensis) |
PF01593(Amino_oxidase) | 4 | GLY A 460ILE A 226SER A 227GLY A 10 | FAD A 501 ( 3.7A)NoneNoneFAD A 501 (-3.4A) | 0.86A | 5alcL-4repA:undetectable | 5alcL-4repA:18.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rt6 | HEME/HEMOPEXIN-BINDING PROTEIN (Haemophilusinfluenzae) |
PF05860(Haemagg_act) | 4 | SER A 385GLY A 412ILE A 437GLY A 442 | None | 0.85A | 5alcL-4rt6A:undetectable | 5alcL-4rt6A:12.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wd3 | L-AMINO ACID LIGASE (Bacillussubtilis) |
PF13535(ATP-grasp_4) | 4 | GLY A 233ILE A 295GLY A 328PHE A 330 | None | 0.79A | 5alcL-4wd3A:undetectable | 5alcL-4wd3A:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x0e | PROBABLENICOTINATE-NUCLEOTIDEADENYLYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF01467(CTP_transf_like) | 4 | GLY A 10ILE A 161SER A 133GLY A 107 | None | 0.62A | 5alcL-4x0eA:undetectable | 5alcL-4x0eA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xat | NOELIN (Homo sapiens) |
PF02191(OLF) | 4 | SER A 242GLY A 243ILE A 449GLY A 247 | None | 0.73A | 5alcL-4xatA:undetectable | 5alcL-4xatA:24.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ybr | NICOTINATE-NUCLEOTIDEADENYLYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF01467(CTP_transf_like) | 4 | GLY A 10ILE A 161SER A 133GLY A 107 | NAP A 301 (-3.1A)NoneNoneNAP A 301 (-3.1A) | 0.76A | 5alcL-4ybrA:undetectable | 5alcL-4ybrA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zkt | BONTOXILYSIN A (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07951(Toxin_R_bind_C)PF07952(Toxin_trans)PF07953(Toxin_R_bind_N) | 4 | TYR A 279GLY A 177ILE A 181GLY A 220 | None | 0.68A | 5alcL-4zktA:undetectable | 5alcL-4zktA:10.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a3y | THERMOLYSIN (Bacillusthermoproteolyticus) |
PF01447(Peptidase_M4)PF02868(Peptidase_M4_C) | 4 | GLY A 223ILE A 236SER A 234GLY A 229 | None | 0.83A | 5alcL-5a3yA:undetectable | 5alcL-5a3yA:17.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5amo | NOELIN (Mus musculus) |
PF02191(OLF) | 4 | SER A 242GLY A 243ILE A 449GLY A 247 | None | 0.71A | 5alcL-5amoA:undetectable | 5alcL-5amoA:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bnn | CAPSID PROTEIN VP2 (Enterovirus D) |
PF00073(Rhv) | 4 | GLY B 133ILE B 167SER B 166GLY B 164 | None | 0.86A | 5alcL-5bnnB:undetectable | 5alcL-5bnnB:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cxp | POSSIBLE XYLANDEGRADATION ENZYME(GLYCOSYL HYDROLASEFAMILY 30-LIKEDOMAIN AND RICINB-LIKE DOMAIN) (Clostridiumacetobutylicum) |
PF02055(Glyco_hydro_30) | 4 | TYR A 115ILE A 203SER A 202PHE A 161 | None | 0.84A | 5alcL-5cxpA:undetectable | 5alcL-5cxpA:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dd4 | TRANSCRIPTIONALREGULATOR ARAR (Bacteroidesthetaiotaomicron) |
PF00293(NUDIX) | 4 | GLY A 14ILE A 18GLY A 47PHE A 49 | None | 0.61A | 5alcL-5dd4A:undetectable | 5alcL-5dd4A:22.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fcs | DIABODY (Homo sapiens) |
PF07686(V-set) | 4 | GLY L 90TRP L 92SER L 97PHE L 101 | None | 0.82A | 5alcL-5fcsL:22.8 | 5alcL-5fcsL:52.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fcu | JR4 FAB LIGHT CHAIN (Macaca mulatta) |
PF07654(C1-set)PF07686(V-set) | 5 | SER L 34TYR L 36GLY L 89TRP L 91PHE L 98 | None | 0.40A | 5alcL-5fcuL:19.0 | 5alcL-5fcuL:84.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fxn | THERMOLYSIN (Bacillusthermoproteolyticus) |
PF01447(Peptidase_M4)PF02868(Peptidase_M4_C) | 4 | GLY A 223ILE A 236SER A 234GLY A 229 | None | 0.83A | 5alcL-5fxnA:undetectable | 5alcL-5fxnA:21.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5grj | AVELUMAB L CHAIN (Homo sapiens) |
PF07686(V-set) | 4 | SER L 36TYR L 38SER L 97PHE L 101 | None | 0.69A | 5alcL-5grjL:20.5 | 5alcL-5grjL:65.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hy7 | PUTATIVE PRE-MRNASPLICING PROTEIN (Chaetomiumthermophilum) |
PF03178(CPSF_A)PF10433(MMS1_N) | 4 | SER A 886GLY A 904SER A 916GLY A 919 | NoneNone CA A1302 (-2.2A)None | 0.57A | 5alcL-5hy7A:undetectable | 5alcL-5hy7A:11.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5i8o | HMM5 ANTIBODY LIGHTCHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | TYR L 94GLY L 92ILE L 21GLY L 102 | None | 0.83A | 5alcL-5i8oL:21.4 | 5alcL-5i8oL:44.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5icl | LIPOATE--PROTEINLIGASE (Enterococcusfaecalis) |
PF03099(BPL_LplA_LipB)PF10437(Lip_prot_lig_C) | 4 | GLY A 283ILE A 42GLY A 71PHE A 285 | NoneLAQ A 401 ( 4.1A)NoneNone | 0.67A | 5alcL-5iclA:undetectable | 5alcL-5iclA:18.26 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ilt | BOVINE FAB A01 LIGHTCHAIN (Bos taurus) |
PF07654(C1-set)PF07686(V-set) | 4 | SER L 34TYR L 36SER L 94PHE L 98 | None | 0.64A | 5alcL-5iltL:26.0 | 5alcL-5iltL:67.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5jz7 | MEDI578 SCFV, LIGHTCHAIN (Homo sapiens) |
PF07686(V-set) | 4 | TYR D 36GLY D 89TRP D 91PHE D 98 | None | 0.64A | 5alcL-5jz7D:21.9 | 5alcL-5jz7D:57.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l9w | ACETOPHENONECARBOXYLASE DELTASUBUNIT (Aromatoleumaromaticum) |
PF02538(Hydantoinase_B) | 4 | SER A 66GLY A 83ILE A 419GLY A 444 | None | 0.75A | 5alcL-5l9wA:undetectable | 5alcL-5l9wA:16.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lae | PEROXISOMALN(1)-ACETYL-SPERMINE/SPERMIDINEOXIDASE,PEROXISOMALN(1)-ACETYL-SPERMINE/SPERMIDINE OXIDASE (Mus musculus) |
PF01593(Amino_oxidase) | 4 | SER A 381GLY A 378ILE A 183GLY A 189 | None | 0.84A | 5alcL-5laeA:undetectable | 5alcL-5laeA:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mje | NANOBODY 8 (Lama glama) |
PF07686(V-set) | 4 | SER B 9GLY B 10ILE B 71SER B 70 | None | 0.84A | 5alcL-5mjeB:13.8 | 5alcL-5mjeB:18.52 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ngv | ANTI-HUMAN ACTRIIBMAB BYM338LIGHT-CHAIN (Homo sapiens) |
no annotation | 4 | TYR L 38GLY L 91GLY L 100PHE L 102 | None | 0.27A | 5alcL-5ngvL:20.3 | 5alcL-5ngvL:37.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o8r | L-LYSINE6-MONOOXYGENASEINVOLVED INDESFERRIOXAMINEBIOSYNTHESIS (Erwiniaamylovora) |
no annotation | 4 | GLY A 10ILE A 5GLY A 32PHE A 34 | None | 0.52A | 5alcL-5o8rA:undetectable | 5alcL-5o8rA:16.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ocy | ACPA E4 FAB FRAGMENT- LIGHT CHAIN (Homo sapiens) |
no annotation | 4 | SER L 35TRP L 92SER L 97PHE L 101 | None | 0.59A | 5alcL-5ocyL:18.6 | 5alcL-5ocyL:72.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t87 | CDII IMMUNITYPROTEIN (Cupriavidustaiwanensis) |
no annotation | 4 | SER A 22GLY A 23ILE A 35SER A 34 | None | 0.82A | 5alcL-5t87A:undetectable | 5alcL-5t87A:17.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t9g | GLYCOSIDE HYDROLASE (Bacteroidesuniformis) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 4 | GLY A 317ILE A 564GLY A 571PHE A 573 | None | 0.86A | 5alcL-5t9gA:6.0 | 5alcL-5t9gA:14.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5u0r | DH270.UCA1 LIGHTCHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | SER L 36TYR L 38SER L 97PHE L 101 | None | 0.76A | 5alcL-5u0rL:17.9 | 5alcL-5u0rL:82.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ukn | DH522UCA FABFRAGMENT LIGHT CHAIN (Macaca mulatta) |
no annotation | 4 | SER L 34TYR L 36GLY L 89PHE L 98 | None | 0.29A | 5alcL-5uknL:26.8 | 5alcL-5uknL:68.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5voh | NADH OXIDASE (Lactobacillusbrevis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | SER A 280GLY A 278ILE A 16GLY A 304 | NoneFAD A 501 (-3.0A)NoneNone | 0.81A | 5alcL-5vohA:undetectable | 5alcL-5vohA:17.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vxb | PROXP-ALA (Caulobactervibrioides) |
PF04073(tRNA_edit) | 4 | SER A 124GLY A 42ILE A 59GLY A 63 | None | 0.84A | 5alcL-5vxbA:undetectable | 5alcL-5vxbA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wjc | KINETOCHORE PROTEINMIS16 (Schizosaccharomycespombe) |
no annotation | 4 | GLY A 154ILE A 225SER A 226GLY A 180 | None | 0.85A | 5alcL-5wjcA:undetectable | 5alcL-5wjcA:15.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wua | ATP-SENSITIVE INWARDRECTIFIER POTASSIUMCHANNEL11,SUPERFOLDER GFP (Mus musculus;syntheticconstruct) |
PF01007(IRK) | 4 | GLY A 132ILE A 114SER A 113GLY A 135 | None | 0.83A | 5alcL-5wuaA:3.6 | 5alcL-5wuaA:15.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x9r | CITRATE-SODIUMSYMPORTER (Klebsiellapneumoniae) |
PF03390(2HCT) | 4 | GLY A 380ILE A 157SER A 156GLY A 151 | None | 0.78A | 5alcL-5x9rA:undetectable | 5alcL-5x9rA:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bvd | LIGHT CHAIN (Clostridiumbotulinum) |
no annotation | 4 | TYR A 292GLY A 186ILE A 190GLY A 234 | None | 0.85A | 5alcL-6bvdA:undetectable | 5alcL-6bvdA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cth | CONCANAVALIN A-LIKELECTIN PROTEINKINASE FAMILYPROTEIN (Theobroma cacao) |
no annotation | 4 | SER A 464GLY A 465ILE A 399SER A 397 | None | 0.82A | 5alcL-6cthA:undetectable | 5alcL-6cthA:16.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d35 | SMOOTHENED,SOLUBLECYTOCHROMEB562,SMOOTHENED (Escherichiacoli;Xenopus laevis) |
no annotation | 4 | SER A 504GLY A 502ILE A 493PHE A 247 | None | 0.83A | 5alcL-6d35A:undetectable | 5alcL-6d35A:15.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6en4 | SPLICING FACTOR 3BSUBUNIT 3 (Homo sapiens) |
no annotation | 4 | SER A 639GLY A 668SER A 696GLY A 672 | None | 0.84A | 5alcL-6en4A:undetectable | 5alcL-6en4A:17.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6epd | PROTEASOME SUBUNITBETA TYPE-6 (Rattusnorvegicus) |
no annotation | 4 | SER 1 166TYR 1 167GLY 1 164GLY 1 130 | None | 0.86A | 5alcL-6epd1:undetectable | 5alcL-6epd1:18.72 |