SIMILAR PATTERNS OF AMINO ACIDS FOR 5ALB_L_TIQL1210_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1b4j | ANTIBODY (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | SER L 34TYR L 36GLY L 89PHE L 98 | None | 0.28A | 5albL-1b4jL:15.9 | 5albL-1b4jL:44.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1flg | PROTEIN(QUINOPROTEINETHANOLDEHYDROGENASE) (Pseudomonasaeruginosa) |
PF01011(PQQ)PF13360(PQQ_2) | 4 | GLY A 346TRP A 315ALA A 314PHE A 347 | None | 0.90A | 5albL-1flgA:undetectable | 5albL-1flgA:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gpz | COMPLEMENT C1RCOMPONENT (Homo sapiens) |
PF00084(Sushi)PF00089(Trypsin) | 4 | SER A 577GLY A 578GLY A 470PHE A 579 | None | 0.88A | 5albL-1gpzA:undetectable | 5albL-1gpzA:19.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k2w | SORBITOLDEHYDROGENASE (Rhodobactersphaeroides) |
PF13561(adh_short_C2) | 4 | SER A 139GLY A 142ALA A 147GLY A 145 | None | 0.91A | 5albL-1k2wA:undetectable | 5albL-1k2wA:18.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kpl | PUTATIVE CLC FAMILY,CHLORINE TRANSPORTPROTEIN (Salmonellaenterica) |
PF00654(Voltage_CLC) | 4 | SER A 350TYR A 94GLY A 351GLY A 354 | None | 0.80A | 5albL-1kplA:undetectable | 5albL-1kplA:17.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1md7 | C1R COMPLEMENTSERINE PROTEASE (Homo sapiens) |
PF00084(Sushi)PF00089(Trypsin) | 4 | SER A 577GLY A 578GLY A 470PHE A 579 | None | 0.91A | 5albL-1md7A:undetectable | 5albL-1md7A:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mo0 | TRIOSEPHOSPHATEISOMERASE (Caenorhabditiselegans) |
PF00121(TIM) | 4 | SER A 234GLY A 9TYR A 46ALA A 44 | None | 0.60A | 5albL-1mo0A:undetectable | 5albL-1mo0A:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o94 | ELECTRON TRANSFERFLAVOPROTEINBETA-SUBUNIT (Methylophilusmethylotrophus) |
PF01012(ETF) | 4 | SER C 133TYR C 137GLY C 101ALA C 222 | None | 0.89A | 5albL-1o94C:undetectable | 5albL-1o94C:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ot5 | KEXIN (Saccharomycescerevisiae) |
PF00082(Peptidase_S8)PF01483(P_proprotein) | 4 | SER A 312GLY A 337ALA A 558GLY A 443 | None | 0.88A | 5albL-1ot5A:2.2 | 5albL-1ot5A:18.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qfw | ANTIBODY (ANTI BETASUBUNIT) (LIGHTCHAIN) (Mus musculus) |
PF07686(V-set) | 4 | SER M 234TYR M 236GLY M 289PHE M 298 | None | 0.47A | 5albL-1qfwM:17.6 | 5albL-1qfwM:29.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v71 | HYPOTHETICAL PROTEINC320.14 INCHROMOSOME III (Schizosaccharomycespombe) |
PF00291(PALP) | 4 | SER A 189GLY A 190ALA A 61GLY A 160 | None | 0.88A | 5albL-1v71A:undetectable | 5albL-1v71A:24.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vcn | CTP SYNTHETASE (Thermusthermophilus) |
PF00117(GATase)PF06418(CTP_synth_N) | 4 | TYR A 387GLY A 389TYR A 473GLY A 363 | None | 0.87A | 5albL-1vcnA:undetectable | 5albL-1vcnA:15.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1whj | RIKEN CDNA1700024K14 (Mus musculus) |
PF01302(CAP_GLY) | 4 | GLY A 56ALA A 79GLY A 83PHE A 85 | None | 0.84A | 5albL-1whjA:undetectable | 5albL-1whjA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yew | PARTICULATE METHANEMONOOXYGENASE, ASUBUNITPARTICULATE METHANEMONOOXYGENASE, BSUBUNIT (Methylococcuscapsulatus) |
PF02461(AMO)PF04744(Monooxygenase_B) | 4 | SER A 207GLY A 204ALA B 128GLY A 199 | None | 0.84A | 5albL-1yewA:3.5 | 5albL-1yewA:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ykg | SULFITE REDUCTASE[NADPH] FLAVOPROTEINALPHA-COMPONENT (Escherichiacoli) |
PF00258(Flavodoxin_1) | 4 | SER A 163GLY A 164TYR A 189ALA A 193 | None | 0.86A | 5albL-1ykgA:undetectable | 5albL-1ykgA:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zos | 5'-METHYLTHIOADENOSINE /S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE (Streptococcuspneumoniae) |
PF01048(PNP_UDP_1) | 4 | SER A 55GLY A 51ALA A 146GLY A 148 | None | 0.80A | 5albL-1zosA:undetectable | 5albL-1zosA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c11 | MEMBRANE COPPERAMINE OXIDASE (Homo sapiens) |
PF01179(Cu_amine_oxid)PF02727(Cu_amine_oxidN2)PF02728(Cu_amine_oxidN3) | 4 | SER A 345GLY A 346ALA A 61GLY A 340 | None | 0.77A | 5albL-2c11A:undetectable | 5albL-2c11A:15.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eh6 | ACETYLORNITHINEAMINOTRANSFERASE (Aquifexaeolicus) |
PF00202(Aminotran_3) | 4 | SER A 269GLY A 272ALA A 238GLY A 250 | None | 0.75A | 5albL-2eh6A:undetectable | 5albL-2eh6A:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fvt | CONSERVEDHYPOTHETICAL PROTEIN (Rhodopseudomonaspalustris) |
PF04430(DUF498) | 4 | TYR A 19GLY A 23GLY A 33PHE A 24 | None | 0.76A | 5albL-2fvtA:undetectable | 5albL-2fvtA:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i9e | TRIOSEPHOSPHATEISOMERASE (Tenebriomolitor) |
PF00121(TIM) | 4 | SER A 234GLY A 9TYR A 46ALA A 44 | None | 0.72A | 5albL-2i9eA:undetectable | 5albL-2i9eA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2inc | TOLUENE, O-XYLENEMONOOXYGENASEOXYGENASE SUBUNIT (Pseudomonasstutzeri) |
PF02332(Phenol_Hydrox)PF04945(YHS) | 4 | GLY A 409TRP A 365TYR A 362GLY A 370 | None | 0.77A | 5albL-2incA:undetectable | 5albL-2incA:16.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j3e | T7I23.11 PROTEIN (Arabidopsisthaliana) |
PF04548(AIG1) | 4 | SER A 51GLY A 48ALA A 69GLY A 45 | GDP A1251 (-3.0A)GDP A1251 (-2.8A)NoneGDP A1251 ( 4.5A) | 0.91A | 5albL-2j3eA:undetectable | 5albL-2j3eA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lbp | LEUCINE-BINDINGPROTEIN (Escherichiacoli) |
PF13458(Peripla_BP_6) | 4 | SER A 98GLY A 75ALA A 16GLY A 9 | None | 0.88A | 5albL-2lbpA:undetectable | 5albL-2lbpA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pfm | ADENYLOSUCCINATELYASE (Bacillusanthracis) |
PF00206(Lyase_1)PF10397(ADSL_C) | 4 | GLY A 330TYR A 5ALA A 321PHE A 122 | None | 0.76A | 5albL-2pfmA:undetectable | 5albL-2pfmA:17.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qy0 | COMPLEMENT C1RSUBCOMPONENT (Homo sapiens) |
PF00089(Trypsin) | 4 | SER B 577GLY B 578GLY B 470PHE B 579 | None | 0.92A | 5albL-2qy0B:undetectable | 5albL-2qy0B:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vc2 | INTEGRIN ALPHA-IIB (Homo sapiens) |
PF01839(FG-GAP)PF13517(VCBS) | 4 | SER A 238GLY A 256ALA A 286GLY A 265 | None | 0.80A | 5albL-2vc2A:undetectable | 5albL-2vc2A:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vpj | KELCH-LIKE PROTEIN12 (Homo sapiens) |
PF01344(Kelch_1) | 4 | GLY A 480TYR A 476ALA A 469GLY A 467 | None | 0.86A | 5albL-2vpjA:undetectable | 5albL-2vpjA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w8z | 6-PHOSPHOGLUCONATEDEHYDROGENASE,DECARBOXYLATING (Geobacillusstearothermophilus) |
PF00393(6PGD)PF03446(NAD_binding_2) | 4 | GLY A 101TYR A 180ALA A 177GLY A 124 | None | 0.90A | 5albL-2w8zA:undetectable | 5albL-2w8zA:16.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wu5 | SUCCINATEDEHYDROGENASEFLAVOPROTEIN SUBUNIT (Escherichiacoli) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 4 | SER A 37GLY A 14ALA A 205GLY A 203 | FAD A 601 (-2.7A)FAD A 601 (-3.1A)NoneFAD A 601 (-3.0A) | 0.91A | 5albL-2wu5A:undetectable | 5albL-2wu5A:15.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x3h | K5 LYASE (Escherichiavirus K1-5) |
no annotation | 4 | SER A 189GLY A 159ALA A 126GLY A 128 | None | 0.75A | 5albL-2x3hA:undetectable | 5albL-2x3hA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z4g | HISTIDINOLPHOSPHATASE (Thermusthermophilus) |
PF02811(PHP)PF13263(PHP_C) | 4 | TYR A 251GLY A 218GLY A 185PHE A 187 | None | 0.77A | 5albL-2z4gA:undetectable | 5albL-2z4gA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ze4 | PHOSPHOLIPASE D (Streptomycesantibioticus) |
PF13091(PLDc_2) | 4 | TYR A 311GLY A 273TRP A 166ALA A 123 | None | 0.90A | 5albL-2ze4A:undetectable | 5albL-2ze4A:17.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ddd | PUTATIVEACETYLTRANSFERASE (Pyrococcushorikoshii) |
PF00583(Acetyltransf_1) | 4 | TYR A 260GLY A 262TYR A 190GLY A 187 | NoneNoneEDO A 302 (-4.5A)None | 0.90A | 5albL-3dddA:undetectable | 5albL-3dddA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fi1 | NA(+)/H(+)ANTIPORTER NHAA (Escherichiacoli) |
PF06965(Na_H_antiport_1) | 4 | GLY A 104TYR A 112GLY A 303PHE A 307 | None | 0.73A | 5albL-3fi1A:undetectable | 5albL-3fi1A:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gr3 | NITROREDUCTASE (Bartonellahenselae) |
PF00881(Nitroreductase) | 4 | SER A 68GLY A 64ALA A 20GLY A 129 | None | 0.91A | 5albL-3gr3A:undetectable | 5albL-3gr3A:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gvh | MALATE DEHYDROGENASE (Brucellaabortus) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 4 | SER A 179GLY A 174ALA A 151GLY A 146 | None | 0.89A | 5albL-3gvhA:undetectable | 5albL-3gvhA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hno | PYROPHOSPHATE-DEPENDENTPHOSPHOFRUCTOKINASE (Nitrosospiramultiformis) |
PF00365(PFK) | 4 | SER A 116TYR A 110GLY A 112GLY A 13 | None | 0.83A | 5albL-3hnoA:undetectable | 5albL-3hnoA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i1i | HOMOSERINEO-ACETYLTRANSFERASE (Bacillusanthracis) |
PF00561(Abhydrolase_1) | 4 | SER A 65GLY A 56ALA A 77GLY A 73 | None | 0.82A | 5albL-3i1iA:undetectable | 5albL-3i1iA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ihv | SUSD HOMOLOG (Bacteroidesthetaiotaomicron) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 4 | SER A 255GLY A 256ALA A 420GLY A 259 | None | 0.79A | 5albL-3ihvA:undetectable | 5albL-3ihvA:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3js8 | CHOLESTEROL OXIDASE (Chromobacteriumsp. DS-1) |
PF01565(FAD_binding_4)PF09129(Chol_subst-bind) | 4 | SER A 163GLY A 143ALA A 106GLY A 137 | NoneFAD A 541 (-3.2A)FAD A 541 (-3.3A)FAD A 541 (-3.4A) | 0.88A | 5albL-3js8A:undetectable | 5albL-3js8A:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2q | PYROPHOSPHATE-DEPENDENTPHOSPHOFRUCTOKINASE (Marinobacterhydrocarbonoclasticus) |
PF00365(PFK) | 4 | SER A 116TYR A 110GLY A 112GLY A 13 | None | 0.90A | 5albL-3k2qA:undetectable | 5albL-3k2qA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qo6 | PROTEASE DO-LIKE 1,CHLOROPLASTIC (Arabidopsisthaliana) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 4 | SER A 156TYR A 134GLY A 157ALA A 306 | None | 0.84A | 5albL-3qo6A:undetectable | 5albL-3qo6A:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3th6 | TRIOSEPHOSPHATEISOMERASE (Rhipicephalusmicroplus) |
PF00121(TIM) | 4 | SER A 235GLY A 10TYR A 47ALA A 45 | None | 0.71A | 5albL-3th6A:undetectable | 5albL-3th6A:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v4p | INTEGRIN ALPHA-4 (Homo sapiens) |
PF01839(FG-GAP)PF08441(Integrin_alpha2) | 4 | SER A 276GLY A 293ALA A 332GLY A 304 | None | 0.59A | 5albL-3v4pA:4.1 | 5albL-3v4pA:17.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vi3 | INTEGRIN ALPHA-5 (Homo sapiens) |
PF01839(FG-GAP)PF08441(Integrin_alpha2) | 4 | SER A 234GLY A 251ALA A 282GLY A 260 | None | 0.84A | 5albL-3vi3A:undetectable | 5albL-3vi3A:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wgc | L-ALLO-THREONINEALDOLASE (Aeromonasjandaei) |
PF01212(Beta_elim_lyase) | 4 | TYR A 44GLY A 45ALA A 188GLY A 50 | None | 0.89A | 5albL-3wgcA:undetectable | 5albL-3wgcA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wla | OXIDIZED POLYVINYLALCOHOL HYDROLASE (Sphingopyxissp. 113P3) |
no annotation | 4 | SER A 117GLY A 102TYR A 217GLY A 111 | None | 0.87A | 5albL-3wlaA:undetectable | 5albL-3wlaA:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wxo | CATALASE-PEROXIDASE (Synechococcuselongatus) |
PF00141(peroxidase) | 4 | SER A 147TYR A 51ALA A 97GLY A 110 | None | 0.77A | 5albL-3wxoA:undetectable | 5albL-3wxoA:16.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zh4 | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE (Streptococcuspneumoniae) |
PF00275(EPSP_synthase) | 4 | TYR A 96GLY A 166TYR A 300ALA A 304 | NonePEG A1420 (-2.7A)NoneNone | 0.87A | 5albL-3zh4A:undetectable | 5albL-3zh4A:19.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zl4 | A17 ANTIBODY FABFRAGMENT LAMBDALIGHT CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | SER L 35TYR L 37GLY L 90PHE L 100 | MES L1217 ( 3.9A)NoneNoneMES L1217 ( 4.9A) | 0.48A | 5albL-3zl4L:20.5 | 5albL-3zl4L:93.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a01 | PROTONPYROPHOSPHATASE (Vigna radiata) |
PF03030(H_PPase) | 4 | SER A 506GLY A 503TYR A 166GLY A 190 | None K A1772 ( 4.5A)NoneNone | 0.85A | 5albL-4a01A:undetectable | 5albL-4a01A:14.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bc5 | XYLULOSE KINASE (Homo sapiens) |
PF00370(FGGY_N)PF02782(FGGY_C) | 4 | GLY A 279TYR A 475ALA A 474GLY A 94 | None | 0.78A | 5albL-4bc5A:undetectable | 5albL-4bc5A:16.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4buh | CLONE M0418 SCFV (Homo sapiens) |
PF07686(V-set) | 4 | TYR A 178TRP A 233GLY A 240PHE A 242 | None | 0.91A | 5albL-4buhA:21.6 | 5albL-4buhA:26.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c51 | CATALASE-PEROXIDASE (Mycobacteriumtuberculosis) |
PF00141(peroxidase) | 4 | SER A 160TYR A 64ALA A 110GLY A 123 | None | 0.73A | 5albL-4c51A:undetectable | 5albL-4c51A:14.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4chb | KELCH-LIKE PROTEIN 2 (Homo sapiens) |
PF01344(Kelch_1) | 4 | GLY A 407TYR A 403ALA A 396GLY A 394 | None | 0.88A | 5albL-4chbA:undetectable | 5albL-4chbA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f1r | CATABOLITEREPRESSION CONTROLPROTEIN (Pseudomonasaeruginosa) |
PF03372(Exo_endo_phos) | 4 | SER A 148TYR A 150ALA A 38GLY A 66 | None | 0.85A | 5albL-4f1rA:undetectable | 5albL-4f1rA:22.26 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4glr | ANTI-PTAU LIGHTCHAIN (Gallus gallus) |
PF07654(C1-set)PF07686(V-set) | 4 | TYR I 36GLY I 89GLY I 96PHE I 98 | None | 0.28A | 5albL-4glrI:21.0 | 5albL-4glrI:77.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hq1 | PROBABLE RECEPTORPROTEIN KINASE TMK1 (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF13855(LRR_8) | 4 | SER A 241GLY A 218TRP A 238PHE A 195 | None | 0.80A | 5albL-4hq1A:undetectable | 5albL-4hq1A:18.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hxe | PUTATIVEUNCHARACTERIZEDPROTEIN PH0594 (Pyrococcushorikoshii) |
PF00326(Peptidase_S9)PF07676(PD40) | 4 | TYR B 247GLY B 233TYR B 239PHE B 219 | NoneNoneHEZ B 705 (-4.5A)None | 0.87A | 5albL-4hxeB:undetectable | 5albL-4hxeB:15.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jo5 | CELLULOSOMEANCHORING PROTEINCOHESIN REGION (Ruminiclostridiumthermocellum) |
PF00942(CBM_3) | 4 | SER A 16GLY A 17ALA A 48GLY A 45 | None | 0.90A | 5albL-4jo5A:2.5 | 5albL-4jo5A:24.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kca | ENDO-1,5-ALPHA-L-ARABINANASE (Bos taurus) |
PF00085(Thioredoxin)PF04616(Glyco_hydro_43)PF16369(GH43_C) | 4 | GLY A 442ALA A 398GLY A 409PHE A 441 | None | 0.80A | 5albL-4kcaA:undetectable | 5albL-4kcaA:16.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lda | TADZ (Pseudomonasaeruginosa) |
PF16968(TadZ_N) | 4 | SER A 72GLY A 69ALA A 93GLY A 64 | None | 0.91A | 5albL-4ldaA:undetectable | 5albL-4ldaA:24.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4mwf | FAB AR3C HEAVY CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | SER A 95TYR A 32TRP A 47GLY A 50 | None | 0.75A | 5albL-4mwfA:14.3 | 5albL-4mwfA:30.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nwz | FAD-DEPENDENTPYRIDINENUCLEOTIDE-DISULFIDEOXIDOREDUCTASE (Caldalkalibacillusthermarum) |
PF07992(Pyr_redox_2) | 4 | GLY A 21TYR A 13ALA A 319GLY A 323 | NoneFAD A 601 (-4.5A)FAD A 601 ( 4.0A)None | 0.90A | 5albL-4nwzA:undetectable | 5albL-4nwzA:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ofz | TREHALOSE-PHOSPHATASE (Brugia malayi) |
no annotation | 4 | SER A 279GLY A 278ALA A 226GLY A 261 | None | 0.90A | 5albL-4ofzA:undetectable | 5albL-4ofzA:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p1c | TOLUENE-4-MONOOXYGENASE SYSTEM PROTEIN A (Pseudomonasmendocina) |
PF02332(Phenol_Hydrox) | 4 | GLY A 409TRP A 365TYR A 362GLY A 370 | None | 0.80A | 5albL-4p1cA:undetectable | 5albL-4p1cA:17.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4p49 | ANTIBODY SCFV B8 (Gallus gallus) |
PF07686(V-set) | 4 | TYR A 30GLY A 84GLY A 91PHE A 93 | None | 0.16A | 5albL-4p49A:17.7 | 5albL-4p49A:37.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qo5 | HYPOTHETICALMULTIHEME PROTEIN (Ignicoccushospitalis) |
PF13435(Cytochrome_C554)PF13447(Multi-haem_cyto) | 4 | TYR A 149GLY A 241ALA A 197GLY A 200 | HEC A 605 (-4.1A)NoneNoneNone | 0.85A | 5albL-4qo5A:undetectable | 5albL-4qo5A:17.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qwv | HIGH-AFFINITYLEUCINE-SPECIFICTRANSPORT SYSTEMPERIPLASMIC BINDINGPROTEIN, CHEMOTAXISPROTEIN CHEY (Escherichiacoli;Thermotogamaritima) |
PF00072(Response_reg)PF13458(Peripla_BP_6) | 4 | SER A 98GLY A 75ALA A 16GLY A 9 | None | 0.83A | 5albL-4qwvA:undetectable | 5albL-4qwvA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4udr | GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE (Methylovorussp. MP688) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 4 | SER A 99GLY A 96ALA A 499GLY A 17 | None | 0.84A | 5albL-4udrA:undetectable | 5albL-4udrA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4um8 | INTEGRIN ALPHA-V (Homo sapiens) |
PF01839(FG-GAP)PF08441(Integrin_alpha2) | 4 | SER A 225GLY A 242ALA A 273GLY A 251 | None | 0.83A | 5albL-4um8A:3.8 | 5albL-4um8A:15.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4uu9 | MEDI7814 (Homo sapiens) |
PF07686(V-set) | 4 | SER B 30GLY B 28ALA B 3GLY B 25 | None | 0.87A | 5albL-4uu9B:17.1 | 5albL-4uu9B:62.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wk4 | INTEGRIN ALPHA-5 (Homo sapiens) |
PF01839(FG-GAP) | 4 | SER A 234GLY A 251ALA A 282GLY A 260 | None | 0.87A | 5albL-4wk4A:undetectable | 5albL-4wk4A:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z3n | PUTATIVE DRUG/SODIUMANTIPORTER (Escherichiacoli) |
PF01554(MatE) | 4 | SER A 158TYR A 150ALA A 69GLY A 72 | None | 0.87A | 5albL-4z3nA:undetectable | 5albL-4z3nA:18.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a2o | NITRATE TRANSPORTER1.1 (Arabidopsisthaliana) |
PF00854(PTR2) | 4 | SER A 81GLY A 79ALA A 70PHE A 511 | None | 0.68A | 5albL-5a2oA:undetectable | 5albL-5a2oA:15.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b48 | 2-OXOACID--FERREDOXIN OXIDOREDUCTASEALPHA SUBUNIT (Sulfurisphaeratokodaii) |
PF01558(POR)PF01855(POR_N) | 4 | SER A 413TYR A 34ALA A 377GLY A 379 | None | 0.92A | 5albL-5b48A:undetectable | 5albL-5b48A:15.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ccx | TRNA(ADENINE(58)-N(1))-METHYLTRANSFERASECATALYTIC SUBUNITTRMT61ATRNA(ADENINE(58)-N(1))-METHYLTRANSFERASENON-CATALYTICSUBUNIT TRM6 (Homo sapiens) |
PF04189(Gcd10p)PF08704(GCD14) | 4 | SER B 455GLY B 456ALA A 24PHE B 457 | None | 0.88A | 5albL-5ccxB:undetectable | 5albL-5ccxB:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dz7 | POLYKETIDEBIOSYNTHESIS PROTEINPKSE (Bacillussubtilis) |
PF00698(Acyl_transf_1) | 4 | GLY A 8TYR A 4ALA A 83GLY A 85 | None | 0.83A | 5albL-5dz7A:undetectable | 5albL-5dz7A:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e6s | INTEGRIN ALPHA-L (Homo sapiens) |
PF00092(VWA)PF01839(FG-GAP)PF08441(Integrin_alpha2) | 4 | SER A 330GLY A 341ALA A 376GLY A 350 | None | 0.68A | 5albL-5e6sA:undetectable | 5albL-5e6sA:14.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5f6h | DH427 ANTIBODY LIGHTCHAIN (Macaca mulatta) |
no annotation | 4 | SER L 36TYR L 38ALA L 97PHE L 101 | None | 0.29A | 5albL-5f6hL:20.1 | 5albL-5f6hL:81.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f7s | GLYCOSIDE HYDROLASEFAMILY 31 (Trueperellapyogenes) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 4 | SER A 522TYR A 528GLY A 518GLY A 469 | None | 0.89A | 5albL-5f7sA:7.9 | 5albL-5f7sA:14.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fcu | JR4 FAB LIGHT CHAIN (Macaca mulatta) |
PF07654(C1-set)PF07686(V-set) | 5 | SER L 34TYR L 36GLY L 89TRP L 91PHE L 98 | None | 0.63A | 5albL-5fcuL:20.1 | 5albL-5fcuL:83.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fmg | PROTEASOME SUBUNITALPHA TYPE (Plasmodiumfalciparum) |
PF00227(Proteasome)PF10584(Proteasome_A_N) | 4 | GLY C 137ALA C 77GLY C 75PHE C 73 | None | 0.74A | 5albL-5fmgC:undetectable | 5albL-5fmgC:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fq6 | SUSC/RAGA FAMILYTONB-LINKED OUTERMEMBRANE PROTEIN (Bacteroidesthetaiotaomicron) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 4 | SER B 438GLY B 431TYR B 360GLY B 357 | None | 0.87A | 5albL-5fq6B:undetectable | 5albL-5fq6B:13.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gqf | LACTO-N-BIOSIDASE (Bifidobacteriumlongum) |
no annotation | 4 | GLY A 46TYR A 167ALA A 107GLY A 83 | None | 0.85A | 5albL-5gqfA:undetectable | 5albL-5gqfA:18.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5if3 | SHORT-CHAINDEHYDROGENASE/REDUCTASE SDR (Burkholderiavietnamiensis) |
PF00106(adh_short) | 4 | SER A 40GLY A 16ALA A 113GLY A 94 | None | 0.84A | 5albL-5if3A:undetectable | 5albL-5if3A:22.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ilt | BOVINE FAB A01 HEAVYCHAINBOVINE FAB A01 LIGHTCHAIN (Bos taurus) |
PF07654(C1-set)PF07686(V-set) | 4 | SER L 34TYR L 36TYR H 149PHE L 98 | None | 0.87A | 5albL-5iltL:19.5 | 5albL-5iltL:66.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5jsa | BROADLY NEUTRALIZINGANTIBODY PGT128LIGHT CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | SER B 34TYR B 36GLY B 89PHE B 98 | None | 0.41A | 5albL-5jsaB:13.8 | 5albL-5jsaB:81.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kxj | L-ASPARTATE OXIDASE (Salmonellaenterica) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 4 | SER A 526GLY A 527ALA A 73GLY A 383 | None | 0.87A | 5albL-5kxjA:undetectable | 5albL-5kxjA:15.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l9w | ACETOPHENONECARBOXYLASE DELTASUBUNIT (Aromatoleumaromaticum) |
PF02538(Hydantoinase_B) | 4 | GLY A 432TYR A 514ALA A 515GLY A 583 | None | 0.84A | 5albL-5l9wA:undetectable | 5albL-5l9wA:16.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lmx | DNA-DIRECTED RNAPOLYMERASES I ANDIII SUBUNITRPAC1,DNA-DIRECTEDRNA POLYMERASES IAND III SUBUNITRPAC1 (Saccharomycescerevisiae) |
PF01000(RNA_pol_A_bac)PF01193(RNA_pol_L) | 4 | SER C 90TYR C 163ALA C 164PHE C 85 | SER C 90 ( 0.0A)TYR C 163 ( 1.3A)ALA C 164 ( 0.0A)PHE C 85 ( 1.3A) | 0.85A | 5albL-5lmxC:undetectable | 5albL-5lmxC:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5neu | INTEGRIN ALPHA-V (Homo sapiens) |
PF01839(FG-GAP)PF08441(Integrin_alpha2) | 4 | SER A 225GLY A 242ALA A 273GLY A 251 | None | 0.84A | 5albL-5neuA:undetectable | 5albL-5neuA:17.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ngv | ANTI-HUMAN ACTRIIBMAB BYM338LIGHT-CHAIN (Homo sapiens) |
no annotation | 4 | TYR L 38GLY L 91GLY L 100PHE L 102 | None | 0.18A | 5albL-5ngvL:20.3 | 5albL-5ngvL:37.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nkp | KELCH-LIKE PROTEIN 3 (Homo sapiens) |
PF01344(Kelch_1) | 4 | GLY A 401TYR A 397ALA A 390GLY A 388 | None | 0.86A | 5albL-5nkpA:undetectable | 5albL-5nkpA:22.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ukn | DH522UCA FABFRAGMENT LIGHT CHAIN (Macaca mulatta) |
no annotation | 4 | SER L 34TYR L 36GLY L 89PHE L 98 | None | 0.25A | 5albL-5uknL:20.6 | 5albL-5uknL:68.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wat | HOMOSERINE KINASE (Corynebacteriumglutamicum) |
no annotation | 4 | SER A 18GLY A 101ALA A 133GLY A 136 | NonePO4 A 401 (-3.9A)None MG A 407 (-4.9A) | 0.72A | 5albL-5watA:undetectable | 5albL-5watA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b7k | ENDO-ALPHA-(1->5)-L-ARABINANASE (Bacilluslicheniformis) |
no annotation | 4 | SER A 228TYR A 224ALA A 172GLY A 235 | None | 0.83A | 5albL-6b7kA:undetectable | 5albL-6b7kA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cuf | () |
no annotation | 4 | GLY 6 29TYR 5 100GLY 6 67PHE 6 67 | None | 0.88A | 5albL-6cuf6:14.7 | 5albL-6cuf6:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6da0 | GLUCOKINASE (Naegleriafowleri) |
no annotation | 4 | GLY A 206TYR A 267ALA A 229GLY A 210 | ANP A 501 (-3.4A)NoneNoneBGC A 500 (-3.5A) | 0.82A | 5albL-6da0A:undetectable | 5albL-6da0A:14.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6epd | PROTEASOME SUBUNITBETA TYPE-6 (Rattusnorvegicus) |
no annotation | 4 | SER 1 166TYR 1 167GLY 1 164GLY 1 130 | None | 0.77A | 5albL-6epd1:undetectable | 5albL-6epd1:19.21 |