SIMILAR PATTERNS OF AMINO ACIDS FOR 5ALB_L_TIQL1210_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fio SSO1 PROTEIN

(Saccharomyces
cerevisiae) 		PF00804
(Syntaxin) 		5 HIS A  61
ILE A  54
THR A  53
TYR A 129
ASP A 133
 None
 1.44A 5albH-1fioA:
undetectable		 5albH-1fioA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica) 		PF00155
(Aminotran_1_2) 		5 ILE A  89
THR A  86
SER A 213
TYR A 111
PRO A 158
 None
PO4  A 800 (-3.9A)
PO4  A 800 (-2.6A)
None
None
 1.20A 5albH-1lc7A:
0.0		 5albH-1lc7A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ut4 NO APICAL MERISTEM
PROTEIN

(Arabidopsis
thaliana) 		PF02365
(NAM) 		5 SER A  92
TRP A  95
ILE A 121
THR A 128
ASP A  55
 None
 1.49A 5albH-1ut4A:
0.0		 5albH-1ut4A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w18 LEVANSUCRASE

(Gluconacetobacter
diazotrophicus) 		PF02435
(Glyco_hydro_68) 		5 SER A 485
ILE A 417
THR A 416
TYR A 484
LEU A 158
 None
 1.28A 5albH-1w18A:
0.3		 5albH-1w18A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x42 HYPOTHETICAL PROTEIN
PH0459

(Pyrococcus
horikoshii) 		PF13419
(HAD_2) 		5 ILE A 121
THR A 146
SER A 148
TYR A 177
ASP A 185
 None
 1.44A 5albH-1x42A:
0.0		 5albH-1x42A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		5 SER A 263
ILE A 266
SER A 272
PRO A 303
LEU A 317
 None
 1.15A 5albH-2vsqA:
1.4		 5albH-2vsqA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9f TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE
REGULATOR, HYBRID
(ONE-COMPONENT
SYSTEM)

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		5 SER A 203
HIS A 214
ILE A 195
THR A 182
PRO A 175
 None
 1.22A 5albH-3v9fA:
0.0		 5albH-3v9fA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vss BETA-FRUCTOFURANOSID
ASE

(Microbacterium
saccharophilum) 		PF02435
(Glyco_hydro_68) 		5 SER A 458
ILE A 390
THR A 389
TYR A 457
LEU A 135
 FRU  A 601 (-2.9A)
None
None
FRU  A 601 (-4.8A)
None
 1.27A 5albH-3vssA:
0.1		 5albH-3vssA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d47 LEVANSUCRASE

(Erwinia
amylovora) 		PF02435
(Glyco_hydro_68) 		5 SER A 353
ILE A 303
THR A 302
TYR A 352
LEU A  69
 FRU  A1415 ( 4.7A)
None
None
GLC  A1416 (-4.0A)
None
 1.45A 5albH-4d47A:
0.0		 5albH-4d47A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmf POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 1

(Homo sapiens) 		PF07686
(V-set)
PF08205
(C2-set_2)
PF13927
(Ig_3) 		5 SER A 209
ILE A 208
THR A 206
SER A 181
TRP A 149
 None
None
NAG  A 402 ( 4.9A)
None
None
 1.13A 5albH-4fmfA:
5.3		 5albH-4fmfA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfy DIHYDROOROTASE

(Burkholderia
cenocepacia) 		PF01979
(Amidohydro_1) 		5 HIS A 291
THR A 217
SER A 269
TYR A 223
LEU A 339
 None
 1.25A 5albH-4lfyA:
undetectable		 5albH-4lfyA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfi SN-GLYCEROL-3-PHOSPH
ATE ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN USPB

(Mycobacterium
tuberculosis) 		PF13416
(SBP_bac_8) 		5 SER A 275
ILE A 279
THR A 280
TYR A 158
PRO A 291
 None
 1.41A 5albH-4mfiA:
undetectable		 5albH-4mfiA:
20.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5alc ANTI-TICAGRELOR FAB
72, HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		9 SER H  33
HIS H  35
TRP H  47
ILE H  52
THR H  56
SER H  58
TYR H  99
ASP H 100
LEU H 100
 None
 0.39A 5albH-5alcH:
30.3		 5albH-5alcH:
97.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du9 CDA PEPTIDE
SYNTHETASE I

(Streptomyces
coelicolor) 		PF00668
(Condensation) 		5 SER A 137
HIS A 139
THR A  33
SER A  35
LEU A  52
 None
 1.06A 5albH-5du9A:
1.0		 5albH-5du9A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ILE A 968
TYR A 956
PRO A 901
ASP A 895
LEU A 892
 None
 1.25A 5albH-5epgA:
undetectable		 5albH-5epgA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp1 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 SER A  92
THR A 117
SER A 120
TYR A  94
LEU A 494
 None
 1.35A 5albH-5fp1A:
undetectable		 5albH-5fp1A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iqk BETA-LACTAMASE RM3

(uncultured
bacterium) 		PF00753
(Lactamase_B) 		5 THR A 183
TYR A 208
PRO A 255
ASP A  77
LEU A 117
 None
 1.49A 5albH-5iqkA:
undetectable		 5albH-5iqkA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens) 		no annotation 5 SER A  10
ILE A 174
TYR A 322
PRO A 328
LEU A  67
 None
 1.45A 5albH-5mg5A:
undetectable		 5albH-5mg5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mul NEURAMINIDASE

(Bacteroides
thetaiotaomicron) 		PF15892
(BNR_4) 		5 ILE A 343
THR A 361
TYR A 282
TRP A 301
ASP A 276
 None
 1.36A 5albH-5mulA:
undetectable		 5albH-5mulA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2u HEAT SHOCK PROTEIN
104

(Saccharomyces
cerevisiae) 		PF02861
(Clp_N) 		5 HIS A  34
ILE A  86
THR A  87
SER A  89
LEU A  73
 None
 1.40A 5albH-5u2uA:
undetectable		 5albH-5u2uA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxa NON-STRUCTURAL
PROTEIN 1

(Yellow fever
virus) 		no annotation 5 SER A 151
HIS A 153
TYR A 160
TRP A 140
PRO A 138
 None
 1.14A 5albH-5yxaA:
undetectable		 5albH-5yxaA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 5 SER A 182
ILE A 138
TRP A 134
PRO A  67
LEU A  79
 None
 1.24A 5albH-6b07A:
undetectable		 5albH-6b07A:
16.74