SIMILAR PATTERNS OF AMINO ACIDS FOR 5ALB_L_TIQL1210

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fio SSO1 PROTEIN

(Saccharomyces
cerevisiae) 		PF00804
(Syntaxin) 		5 HIS A  61
ILE A  54
THR A  53
TYR A 129
ASP A 133
 None
 1.44A 5albH-1fioA:
undetectable		 5albH-1fioA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica) 		PF00155
(Aminotran_1_2) 		5 ILE A  89
THR A  86
SER A 213
TYR A 111
PRO A 158
 None
PO4  A 800 (-3.9A)
PO4  A 800 (-2.6A)
None
None
 1.20A 5albH-1lc7A:
0.0		 5albH-1lc7A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ut4 NO APICAL MERISTEM
PROTEIN

(Arabidopsis
thaliana) 		PF02365
(NAM) 		5 SER A  92
TRP A  95
ILE A 121
THR A 128
ASP A  55
 None
 1.49A 5albH-1ut4A:
0.0		 5albH-1ut4A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w18 LEVANSUCRASE

(Gluconacetobacter
diazotrophicus) 		PF02435
(Glyco_hydro_68) 		5 SER A 485
ILE A 417
THR A 416
TYR A 484
LEU A 158
 None
 1.28A 5albH-1w18A:
0.3		 5albH-1w18A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x42 HYPOTHETICAL PROTEIN
PH0459

(Pyrococcus
horikoshii) 		PF13419
(HAD_2) 		5 ILE A 121
THR A 146
SER A 148
TYR A 177
ASP A 185
 None
 1.44A 5albH-1x42A:
0.0		 5albH-1x42A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		5 SER A 263
ILE A 266
SER A 272
PRO A 303
LEU A 317
 None
 1.15A 5albH-2vsqA:
1.4		 5albH-2vsqA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9f TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE
REGULATOR, HYBRID
(ONE-COMPONENT
SYSTEM)

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		5 SER A 203
HIS A 214
ILE A 195
THR A 182
PRO A 175
 None
 1.22A 5albH-3v9fA:
0.0		 5albH-3v9fA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vss BETA-FRUCTOFURANOSID
ASE

(Microbacterium
saccharophilum) 		PF02435
(Glyco_hydro_68) 		5 SER A 458
ILE A 390
THR A 389
TYR A 457
LEU A 135
 FRU  A 601 (-2.9A)
None
None
FRU  A 601 (-4.8A)
None
 1.27A 5albH-3vssA:
0.1		 5albH-3vssA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d47 LEVANSUCRASE

(Erwinia
amylovora) 		PF02435
(Glyco_hydro_68) 		5 SER A 353
ILE A 303
THR A 302
TYR A 352
LEU A  69
 FRU  A1415 ( 4.7A)
None
None
GLC  A1416 (-4.0A)
None
 1.45A 5albH-4d47A:
0.0		 5albH-4d47A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmf POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 1

(Homo sapiens) 		PF07686
(V-set)
PF08205
(C2-set_2)
PF13927
(Ig_3) 		5 SER A 209
ILE A 208
THR A 206
SER A 181
TRP A 149
 None
None
NAG  A 402 ( 4.9A)
None
None
 1.13A 5albH-4fmfA:
5.3		 5albH-4fmfA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfy DIHYDROOROTASE

(Burkholderia
cenocepacia) 		PF01979
(Amidohydro_1) 		5 HIS A 291
THR A 217
SER A 269
TYR A 223
LEU A 339
 None
 1.25A 5albH-4lfyA:
undetectable		 5albH-4lfyA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfi SN-GLYCEROL-3-PHOSPH
ATE ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN USPB

(Mycobacterium
tuberculosis) 		PF13416
(SBP_bac_8) 		5 SER A 275
ILE A 279
THR A 280
TYR A 158
PRO A 291
 None
 1.41A 5albH-4mfiA:
undetectable		 5albH-4mfiA:
20.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5alc ANTI-TICAGRELOR FAB
72, HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		9 SER H  33
HIS H  35
TRP H  47
ILE H  52
THR H  56
SER H  58
TYR H  99
ASP H 100
LEU H 100
 None
 0.39A 5albH-5alcH:
30.3		 5albH-5alcH:
97.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du9 CDA PEPTIDE
SYNTHETASE I

(Streptomyces
coelicolor) 		PF00668
(Condensation) 		5 SER A 137
HIS A 139
THR A  33
SER A  35
LEU A  52
 None
 1.06A 5albH-5du9A:
1.0		 5albH-5du9A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ILE A 968
TYR A 956
PRO A 901
ASP A 895
LEU A 892
 None
 1.25A 5albH-5epgA:
undetectable		 5albH-5epgA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp1 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 SER A  92
THR A 117
SER A 120
TYR A  94
LEU A 494
 None
 1.35A 5albH-5fp1A:
undetectable		 5albH-5fp1A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iqk BETA-LACTAMASE RM3

(uncultured
bacterium) 		PF00753
(Lactamase_B) 		5 THR A 183
TYR A 208
PRO A 255
ASP A  77
LEU A 117
 None
 1.49A 5albH-5iqkA:
undetectable		 5albH-5iqkA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens) 		no annotation 5 SER A  10
ILE A 174
TYR A 322
PRO A 328
LEU A  67
 None
 1.45A 5albH-5mg5A:
undetectable		 5albH-5mg5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mul NEURAMINIDASE

(Bacteroides
thetaiotaomicron) 		PF15892
(BNR_4) 		5 ILE A 343
THR A 361
TYR A 282
TRP A 301
ASP A 276
 None
 1.36A 5albH-5mulA:
undetectable		 5albH-5mulA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2u HEAT SHOCK PROTEIN
104

(Saccharomyces
cerevisiae) 		PF02861
(Clp_N) 		5 HIS A  34
ILE A  86
THR A  87
SER A  89
LEU A  73
 None
 1.40A 5albH-5u2uA:
undetectable		 5albH-5u2uA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxa NON-STRUCTURAL
PROTEIN 1

(Yellow fever
virus) 		no annotation 5 SER A 151
HIS A 153
TYR A 160
TRP A 140
PRO A 138
 None
 1.14A 5albH-5yxaA:
undetectable		 5albH-5yxaA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 5 SER A 182
ILE A 138
TRP A 134
PRO A  67
LEU A  79
 None
 1.24A 5albH-6b07A:
undetectable		 5albH-6b07A:
16.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b4j ANTIBODY

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER L  34
TYR L  36
GLY L  89
PHE L  98
 None
 0.28A 5albL-1b4jL:
15.9		 5albL-1b4jL:
44.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 GLY A 346
TRP A 315
ALA A 314
PHE A 347
 None
 0.90A 5albL-1flgA:
undetectable		 5albL-1flgA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpz COMPLEMENT C1R
COMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		4 SER A 577
GLY A 578
GLY A 470
PHE A 579
 None
 0.88A 5albL-1gpzA:
undetectable		 5albL-1gpzA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2w SORBITOL
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		PF13561
(adh_short_C2) 		4 SER A 139
GLY A 142
ALA A 147
GLY A 145
 None
 0.91A 5albL-1k2wA:
undetectable		 5albL-1k2wA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF00654
(Voltage_CLC) 		4 SER A 350
TYR A  94
GLY A 351
GLY A 354
 None
 0.80A 5albL-1kplA:
undetectable		 5albL-1kplA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1md7 C1R COMPLEMENT
SERINE PROTEASE

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		4 SER A 577
GLY A 578
GLY A 470
PHE A 579
 None
 0.91A 5albL-1md7A:
undetectable		 5albL-1md7A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mo0 TRIOSEPHOSPHATE
ISOMERASE

(Caenorhabditis
elegans) 		PF00121
(TIM) 		4 SER A 234
GLY A   9
TYR A  46
ALA A  44
 None
 0.60A 5albL-1mo0A:
undetectable		 5albL-1mo0A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o94 ELECTRON TRANSFER
FLAVOPROTEIN
BETA-SUBUNIT

(Methylophilus
methylotrophus) 		PF01012
(ETF) 		4 SER C 133
TYR C 137
GLY C 101
ALA C 222
 None
 0.89A 5albL-1o94C:
undetectable		 5albL-1o94C:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot5 KEXIN

(Saccharomyces
cerevisiae) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 SER A 312
GLY A 337
ALA A 558
GLY A 443
 None
 0.88A 5albL-1ot5A:
2.2		 5albL-1ot5A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfw ANTIBODY (ANTI BETA
SUBUNIT) (LIGHT
CHAIN)

(Mus musculus) 		PF07686
(V-set) 		4 SER M 234
TYR M 236
GLY M 289
PHE M 298
 None
 0.47A 5albL-1qfwM:
17.6		 5albL-1qfwM:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v71 HYPOTHETICAL PROTEIN
C320.14 IN
CHROMOSOME III

(Schizosaccharomyces
pombe) 		PF00291
(PALP) 		4 SER A 189
GLY A 190
ALA A  61
GLY A 160
 None
 0.88A 5albL-1v71A:
undetectable		 5albL-1v71A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcn CTP SYNTHETASE

(Thermus
thermophilus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 TYR A 387
GLY A 389
TYR A 473
GLY A 363
 None
 0.87A 5albL-1vcnA:
undetectable		 5albL-1vcnA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1whj RIKEN CDNA
1700024K14

(Mus musculus) 		PF01302
(CAP_GLY) 		4 GLY A  56
ALA A  79
GLY A  83
PHE A  85
 None
 0.84A 5albL-1whjA:
undetectable		 5albL-1whjA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT

(Methylococcus
capsulatus) 		PF02461
(AMO)
PF04744
(Monooxygenase_B) 		4 SER A 207
GLY A 204
ALA B 128
GLY A 199
 None
 0.84A 5albL-1yewA:
3.5		 5albL-1yewA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykg SULFITE REDUCTASE
[NADPH] FLAVOPROTEIN
ALPHA-COMPONENT

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		4 SER A 163
GLY A 164
TYR A 189
ALA A 193
 None
 0.86A 5albL-1ykgA:
undetectable		 5albL-1ykgA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE

(Streptococcus
pneumoniae) 		PF01048
(PNP_UDP_1) 		4 SER A  55
GLY A  51
ALA A 146
GLY A 148
 None
 0.80A 5albL-1zosA:
undetectable		 5albL-1zosA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 SER A 345
GLY A 346
ALA A  61
GLY A 340
 None
 0.77A 5albL-2c11A:
undetectable		 5albL-2c11A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eh6 ACETYLORNITHINE
AMINOTRANSFERASE

(Aquifex
aeolicus) 		PF00202
(Aminotran_3) 		4 SER A 269
GLY A 272
ALA A 238
GLY A 250
 None
 0.75A 5albL-2eh6A:
undetectable		 5albL-2eh6A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvt CONSERVED
HYPOTHETICAL PROTEIN

(Rhodopseudomonas
palustris) 		PF04430
(DUF498) 		4 TYR A  19
GLY A  23
GLY A  33
PHE A  24
 None
 0.76A 5albL-2fvtA:
undetectable		 5albL-2fvtA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9e TRIOSEPHOSPHATE
ISOMERASE

(Tenebrio
molitor) 		PF00121
(TIM) 		4 SER A 234
GLY A   9
TYR A  46
ALA A  44
 None
 0.72A 5albL-2i9eA:
undetectable		 5albL-2i9eA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		4 GLY A 409
TRP A 365
TYR A 362
GLY A 370
 None
 0.77A 5albL-2incA:
undetectable		 5albL-2incA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3e T7I23.11 PROTEIN

(Arabidopsis
thaliana) 		PF04548
(AIG1) 		4 SER A  51
GLY A  48
ALA A  69
GLY A  45
 GDP  A1251 (-3.0A)
GDP  A1251 (-2.8A)
None
GDP  A1251 ( 4.5A)
 0.91A 5albL-2j3eA:
undetectable		 5albL-2j3eA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbp LEUCINE-BINDING
PROTEIN

(Escherichia
coli) 		PF13458
(Peripla_BP_6) 		4 SER A  98
GLY A  75
ALA A  16
GLY A   9
 None
 0.88A 5albL-2lbpA:
undetectable		 5albL-2lbpA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfm ADENYLOSUCCINATE
LYASE

(Bacillus
anthracis) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 GLY A 330
TYR A   5
ALA A 321
PHE A 122
 None
 0.76A 5albL-2pfmA:
undetectable		 5albL-2pfmA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy0 COMPLEMENT C1R
SUBCOMPONENT

(Homo sapiens) 		PF00089
(Trypsin) 		4 SER B 577
GLY B 578
GLY B 470
PHE B 579
 None
 0.92A 5albL-2qy0B:
undetectable		 5albL-2qy0B:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vc2 INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF13517
(VCBS) 		4 SER A 238
GLY A 256
ALA A 286
GLY A 265
 None
 0.80A 5albL-2vc2A:
undetectable		 5albL-2vc2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpj KELCH-LIKE PROTEIN
12

(Homo sapiens) 		PF01344
(Kelch_1) 		4 GLY A 480
TYR A 476
ALA A 469
GLY A 467
 None
 0.86A 5albL-2vpjA:
undetectable		 5albL-2vpjA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Geobacillus
stearothermophilus) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 GLY A 101
TYR A 180
ALA A 177
GLY A 124
 None
 0.90A 5albL-2w8zA:
undetectable		 5albL-2w8zA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 SER A  37
GLY A  14
ALA A 205
GLY A 203
 FAD  A 601 (-2.7A)
FAD  A 601 (-3.1A)
None
FAD  A 601 (-3.0A)
 0.91A 5albL-2wu5A:
undetectable		 5albL-2wu5A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3h K5 LYASE

(Escherichia
virus K1-5) 		no annotation 4 SER A 189
GLY A 159
ALA A 126
GLY A 128
 None
 0.75A 5albL-2x3hA:
undetectable		 5albL-2x3hA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4g HISTIDINOL
PHOSPHATASE

(Thermus
thermophilus) 		PF02811
(PHP)
PF13263
(PHP_C) 		4 TYR A 251
GLY A 218
GLY A 185
PHE A 187
 None
 0.77A 5albL-2z4gA:
undetectable		 5albL-2z4gA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze4 PHOSPHOLIPASE D

(Streptomyces
antibioticus) 		PF13091
(PLDc_2) 		4 TYR A 311
GLY A 273
TRP A 166
ALA A 123
 None
 0.90A 5albL-2ze4A:
undetectable		 5albL-2ze4A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddd PUTATIVE
ACETYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF00583
(Acetyltransf_1) 		4 TYR A 260
GLY A 262
TYR A 190
GLY A 187
 None
None
EDO  A 302 (-4.5A)
None
 0.90A 5albL-3dddA:
undetectable		 5albL-3dddA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi1 NA(+)/H(+)
ANTIPORTER NHAA

(Escherichia
coli) 		PF06965
(Na_H_antiport_1) 		4 GLY A 104
TYR A 112
GLY A 303
PHE A 307
 None
 0.73A 5albL-3fi1A:
undetectable		 5albL-3fi1A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gr3 NITROREDUCTASE

(Bartonella
henselae) 		PF00881
(Nitroreductase) 		4 SER A  68
GLY A  64
ALA A  20
GLY A 129
 None
 0.91A 5albL-3gr3A:
undetectable		 5albL-3gr3A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvh MALATE DEHYDROGENASE

(Brucella
abortus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 SER A 179
GLY A 174
ALA A 151
GLY A 146
 None
 0.89A 5albL-3gvhA:
undetectable		 5albL-3gvhA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE

(Nitrosospira
multiformis) 		PF00365
(PFK) 		4 SER A 116
TYR A 110
GLY A 112
GLY A  13
 None
 0.83A 5albL-3hnoA:
undetectable		 5albL-3hnoA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1i HOMOSERINE
O-ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		4 SER A  65
GLY A  56
ALA A  77
GLY A  73
 None
 0.82A 5albL-3i1iA:
undetectable		 5albL-3i1iA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 SER A 255
GLY A 256
ALA A 420
GLY A 259
 None
 0.79A 5albL-3ihvA:
undetectable		 5albL-3ihvA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js8 CHOLESTEROL OXIDASE

(Chromobacterium
sp. DS-1) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		4 SER A 163
GLY A 143
ALA A 106
GLY A 137
 None
FAD  A 541 (-3.2A)
FAD  A 541 (-3.3A)
FAD  A 541 (-3.4A)
 0.88A 5albL-3js8A:
undetectable		 5albL-3js8A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE

(Marinobacter
hydrocarbonoclasticus) 		PF00365
(PFK) 		4 SER A 116
TYR A 110
GLY A 112
GLY A  13
 None
 0.90A 5albL-3k2qA:
undetectable		 5albL-3k2qA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qo6 PROTEASE DO-LIKE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 SER A 156
TYR A 134
GLY A 157
ALA A 306
 None
 0.84A 5albL-3qo6A:
undetectable		 5albL-3qo6A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3th6 TRIOSEPHOSPHATE
ISOMERASE

(Rhipicephalus
microplus) 		PF00121
(TIM) 		4 SER A 235
GLY A  10
TYR A  47
ALA A  45
 None
 0.71A 5albL-3th6A:
undetectable		 5albL-3th6A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4p INTEGRIN ALPHA-4

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 SER A 276
GLY A 293
ALA A 332
GLY A 304
 None
 0.59A 5albL-3v4pA:
4.1		 5albL-3v4pA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi3 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 SER A 234
GLY A 251
ALA A 282
GLY A 260
 None
 0.84A 5albL-3vi3A:
undetectable		 5albL-3vi3A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgc L-ALLO-THREONINE
ALDOLASE

(Aeromonas
jandaei) 		PF01212
(Beta_elim_lyase) 		4 TYR A  44
GLY A  45
ALA A 188
GLY A  50
 None
 0.89A 5albL-3wgcA:
undetectable		 5albL-3wgcA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE

(Sphingopyxis
sp. 113P3) 		no annotation 4 SER A 117
GLY A 102
TYR A 217
GLY A 111
 None
 0.87A 5albL-3wlaA:
undetectable		 5albL-3wlaA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus) 		PF00141
(peroxidase) 		4 SER A 147
TYR A  51
ALA A  97
GLY A 110
 None
 0.77A 5albL-3wxoA:
undetectable		 5albL-3wxoA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		4 TYR A  96
GLY A 166
TYR A 300
ALA A 304
 None
PEG  A1420 (-2.7A)
None
None
 0.87A 5albL-3zh4A:
undetectable		 5albL-3zh4A:
19.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zl4 A17 ANTIBODY FAB
FRAGMENT LAMBDA
LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER L  35
TYR L  37
GLY L  90
PHE L 100
 MES  L1217 ( 3.9A)
None
None
MES  L1217 ( 4.9A)
 0.48A 5albL-3zl4L:
20.5		 5albL-3zl4L:
93.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		4 SER A 506
GLY A 503
TYR A 166
GLY A 190
 None
K  A1772 ( 4.5A)
None
None
 0.85A 5albL-4a01A:
undetectable		 5albL-4a01A:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc5 XYLULOSE KINASE

(Homo sapiens) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 GLY A 279
TYR A 475
ALA A 474
GLY A  94
 None
 0.78A 5albL-4bc5A:
undetectable		 5albL-4bc5A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buh CLONE M0418 SCFV

(Homo sapiens) 		PF07686
(V-set) 		4 TYR A 178
TRP A 233
GLY A 240
PHE A 242
 None
 0.91A 5albL-4buhA:
21.6		 5albL-4buhA:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		4 SER A 160
TYR A  64
ALA A 110
GLY A 123
 None
 0.73A 5albL-4c51A:
undetectable		 5albL-4c51A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chb KELCH-LIKE PROTEIN 2

(Homo sapiens) 		PF01344
(Kelch_1) 		4 GLY A 407
TYR A 403
ALA A 396
GLY A 394
 None
 0.88A 5albL-4chbA:
undetectable		 5albL-4chbA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1r CATABOLITE
REPRESSION CONTROL
PROTEIN

(Pseudomonas
aeruginosa) 		PF03372
(Exo_endo_phos) 		4 SER A 148
TYR A 150
ALA A  38
GLY A  66
 None
 0.85A 5albL-4f1rA:
undetectable		 5albL-4f1rA:
22.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4glr ANTI-PTAU LIGHT
CHAIN

(Gallus gallus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR I  36
GLY I  89
GLY I  96
PHE I  98
 None
 0.28A 5albL-4glrI:
21.0		 5albL-4glrI:
77.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 SER A 241
GLY A 218
TRP A 238
PHE A 195
 None
 0.80A 5albL-4hq1A:
undetectable		 5albL-4hq1A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594

(Pyrococcus
horikoshii) 		PF00326
(Peptidase_S9)
PF07676
(PD40) 		4 TYR B 247
GLY B 233
TYR B 239
PHE B 219
 None
None
HEZ  B 705 (-4.5A)
None
 0.87A 5albL-4hxeB:
undetectable		 5albL-4hxeB:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo5 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		4 SER A  16
GLY A  17
ALA A  48
GLY A  45
 None
 0.90A 5albL-4jo5A:
2.5		 5albL-4jo5A:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kca ENDO-1,5-ALPHA-L-ARA
BINANASE

(Bos taurus) 		PF00085
(Thioredoxin)
PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 GLY A 442
ALA A 398
GLY A 409
PHE A 441
 None
 0.80A 5albL-4kcaA:
undetectable		 5albL-4kcaA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lda TADZ

(Pseudomonas
aeruginosa) 		PF16968
(TadZ_N) 		4 SER A  72
GLY A  69
ALA A  93
GLY A  64
 None
 0.91A 5albL-4ldaA:
undetectable		 5albL-4ldaA:
24.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mwf FAB AR3C HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER A  95
TYR A  32
TRP A  47
GLY A  50
 None
 0.75A 5albL-4mwfA:
14.3		 5albL-4mwfA:
30.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwz FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Caldalkalibacillus
thermarum) 		PF07992
(Pyr_redox_2) 		4 GLY A  21
TYR A  13
ALA A 319
GLY A 323
 None
FAD  A 601 (-4.5A)
FAD  A 601 ( 4.0A)
None
 0.90A 5albL-4nwzA:
undetectable		 5albL-4nwzA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofz TREHALOSE-PHOSPHATAS
E

(Brugia malayi) 		no annotation 4 SER A 279
GLY A 278
ALA A 226
GLY A 261
 None
 0.90A 5albL-4ofzA:
undetectable		 5albL-4ofzA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1c TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN A

(Pseudomonas
mendocina) 		PF02332
(Phenol_Hydrox) 		4 GLY A 409
TRP A 365
TYR A 362
GLY A 370
 None
 0.80A 5albL-4p1cA:
undetectable		 5albL-4p1cA:
17.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p49 ANTIBODY SCFV B8

(Gallus gallus) 		PF07686
(V-set) 		4 TYR A  30
GLY A  84
GLY A  91
PHE A  93
 None
 0.16A 5albL-4p49A:
17.7		 5albL-4p49A:
37.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qo5 HYPOTHETICAL
MULTIHEME PROTEIN

(Ignicoccus
hospitalis) 		PF13435
(Cytochrome_C554)
PF13447
(Multi-haem_cyto) 		4 TYR A 149
GLY A 241
ALA A 197
GLY A 200
 HEC  A 605 (-4.1A)
None
None
None
 0.85A 5albL-4qo5A:
undetectable		 5albL-4qo5A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qwv HIGH-AFFINITY
LEUCINE-SPECIFIC
TRANSPORT SYSTEM
PERIPLASMIC BINDING
PROTEIN, CHEMOTAXIS
PROTEIN CHEY

(Escherichia
coli;
Thermotoga
maritima) 		PF00072
(Response_reg)
PF13458
(Peripla_BP_6) 		4 SER A  98
GLY A  75
ALA A  16
GLY A   9
 None
 0.83A 5albL-4qwvA:
undetectable		 5albL-4qwvA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE

(Methylovorus
sp. MP688) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 SER A  99
GLY A  96
ALA A 499
GLY A  17
 None
 0.84A 5albL-4udrA:
undetectable		 5albL-4udrA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 SER A 225
GLY A 242
ALA A 273
GLY A 251
 None
 0.83A 5albL-4um8A:
3.8		 5albL-4um8A:
15.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uu9 MEDI7814

(Homo sapiens) 		PF07686
(V-set) 		4 SER B  30
GLY B  28
ALA B   3
GLY B  25
 None
 0.87A 5albL-4uu9B:
17.1		 5albL-4uu9B:
62.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk4 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP) 		4 SER A 234
GLY A 251
ALA A 282
GLY A 260
 None
 0.87A 5albL-4wk4A:
undetectable		 5albL-4wk4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER

(Escherichia
coli) 		PF01554
(MatE) 		4 SER A 158
TYR A 150
ALA A  69
GLY A  72
 None
 0.87A 5albL-4z3nA:
undetectable		 5albL-4z3nA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2o NITRATE TRANSPORTER
1.1

(Arabidopsis
thaliana) 		PF00854
(PTR2) 		4 SER A  81
GLY A  79
ALA A  70
PHE A 511
 None
 0.68A 5albL-5a2oA:
undetectable		 5albL-5a2oA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01558
(POR)
PF01855
(POR_N) 		4 SER A 413
TYR A  34
ALA A 377
GLY A 379
 None
 0.92A 5albL-5b48A:
undetectable		 5albL-5b48A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRMT61A
TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
NON-CATALYTIC
SUBUNIT TRM6

(Homo sapiens) 		PF04189
(Gcd10p)
PF08704
(GCD14) 		4 SER B 455
GLY B 456
ALA A  24
PHE B 457
 None
 0.88A 5albL-5ccxB:
undetectable		 5albL-5ccxB:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE

(Bacillus
subtilis) 		PF00698
(Acyl_transf_1) 		4 GLY A   8
TYR A   4
ALA A  83
GLY A  85
 None
 0.83A 5albL-5dz7A:
undetectable		 5albL-5dz7A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN ALPHA-L

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 SER A 330
GLY A 341
ALA A 376
GLY A 350
 None
 0.68A 5albL-5e6sA:
undetectable		 5albL-5e6sA:
14.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f6h DH427 ANTIBODY LIGHT
CHAIN

(Macaca mulatta) 		no annotation 4 SER L  36
TYR L  38
ALA L  97
PHE L 101
 None
 0.29A 5albL-5f6hL:
20.1		 5albL-5f6hL:
81.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 SER A 522
TYR A 528
GLY A 518
GLY A 469
 None
 0.89A 5albL-5f7sA:
7.9		 5albL-5f7sA:
14.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fcu JR4 FAB LIGHT CHAIN

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		5 SER L  34
TYR L  36
GLY L  89
TRP L  91
PHE L  98
 None
 0.63A 5albL-5fcuL:
20.1		 5albL-5fcuL:
83.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
ALPHA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		4 GLY C 137
ALA C  77
GLY C  75
PHE C  73
 None
 0.74A 5albL-5fmgC:
undetectable		 5albL-5fmgC:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 SER B 438
GLY B 431
TYR B 360
GLY B 357
 None
 0.87A 5albL-5fq6B:
undetectable		 5albL-5fq6B:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqf LACTO-N-BIOSIDASE

(Bifidobacterium
longum) 		no annotation 4 GLY A  46
TYR A 167
ALA A 107
GLY A  83
 None
 0.85A 5albL-5gqfA:
undetectable		 5albL-5gqfA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5if3 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Burkholderia
vietnamiensis) 		PF00106
(adh_short) 		4 SER A  40
GLY A  16
ALA A 113
GLY A  94
 None
 0.84A 5albL-5if3A:
undetectable		 5albL-5if3A:
22.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ilt BOVINE FAB A01 HEAVY
CHAIN
BOVINE FAB A01 LIGHT
CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER L  34
TYR L  36
TYR H 149
PHE L  98
 None
 0.87A 5albL-5iltL:
19.5		 5albL-5iltL:
66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jsa BROADLY NEUTRALIZING
ANTIBODY PGT128
LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER B  34
TYR B  36
GLY B  89
PHE B  98
 None
 0.41A 5albL-5jsaB:
13.8		 5albL-5jsaB:
81.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxj L-ASPARTATE OXIDASE

(Salmonella
enterica) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 SER A 526
GLY A 527
ALA A  73
GLY A 383
 None
 0.87A 5albL-5kxjA:
undetectable		 5albL-5kxjA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT

(Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B) 		4 GLY A 432
TYR A 514
ALA A 515
GLY A 583
 None
 0.84A 5albL-5l9wA:
undetectable		 5albL-5l9wA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmx DNA-DIRECTED RNA
POLYMERASES I AND
III SUBUNIT
RPAC1,DNA-DIRECTED
RNA POLYMERASES I
AND III SUBUNIT
RPAC1

(Saccharomyces
cerevisiae) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		4 SER C  90
TYR C 163
ALA C 164
PHE C  85
 SER  C  90 ( 0.0A)
TYR  C 163 ( 1.3A)
ALA  C 164 ( 0.0A)
PHE  C  85 ( 1.3A)
 0.85A 5albL-5lmxC:
undetectable		 5albL-5lmxC:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5neu INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 SER A 225
GLY A 242
ALA A 273
GLY A 251
 None
 0.84A 5albL-5neuA:
undetectable		 5albL-5neuA:
17.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ngv ANTI-HUMAN ACTRIIB
MAB BYM338
LIGHT-CHAIN

(Homo sapiens) 		no annotation 4 TYR L  38
GLY L  91
GLY L 100
PHE L 102
 None
 0.18A 5albL-5ngvL:
20.3		 5albL-5ngvL:
37.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkp KELCH-LIKE PROTEIN 3

(Homo sapiens) 		PF01344
(Kelch_1) 		4 GLY A 401
TYR A 397
ALA A 390
GLY A 388
 None
 0.86A 5albL-5nkpA:
undetectable		 5albL-5nkpA:
22.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ukn DH522UCA FAB
FRAGMENT LIGHT CHAIN

(Macaca mulatta) 		no annotation 4 SER L  34
TYR L  36
GLY L  89
PHE L  98
 None
 0.25A 5albL-5uknL:
20.6		 5albL-5uknL:
68.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wat HOMOSERINE KINASE

(Corynebacterium
glutamicum) 		no annotation 4 SER A  18
GLY A 101
ALA A 133
GLY A 136
 None
PO4  A 401 (-3.9A)
None
MG  A 407 (-4.9A)
 0.72A 5albL-5watA:
undetectable		 5albL-5watA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE

(Bacillus
licheniformis) 		no annotation 4 SER A 228
TYR A 224
ALA A 172
GLY A 235
 None
 0.83A 5albL-6b7kA:
undetectable		 5albL-6b7kA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cuf

() 		no annotation 4 GLY 6  29
TYR 5 100
GLY 6  67
PHE 6  67
 None
 0.88A 5albL-6cuf6:
14.7		 5albL-6cuf6:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6da0 GLUCOKINASE

(Naegleria
fowleri) 		no annotation 4 GLY A 206
TYR A 267
ALA A 229
GLY A 210
 ANP  A 501 (-3.4A)
None
None
BGC  A 500 (-3.5A)
 0.82A 5albL-6da0A:
undetectable		 5albL-6da0A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epd PROTEASOME SUBUNIT
BETA TYPE-6

(Rattus
norvegicus) 		no annotation 4 SER 1 166
TYR 1 167
GLY 1 164
GLY 1 130
 None
 0.77A 5albL-6epd1:
undetectable		 5albL-6epd1:
19.21