SIMILAR PATTERNS OF AMINO ACIDS FOR 5AJQ_B_DB8B800_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aep APOLIPOPHORIN III

(Locusta
migratoria) 		no annotation 5 ALA A 116
ILE A   7
GLY A 109
LEU A  14
ALA A 138
 None
 1.40A 5ajqB-1aepA:
undetectable		 5ajqB-1aepA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b2h PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Salmonella
enterica) 		PF00496
(SBP_bac_5) 		5 ILE A 125
GLY A 135
LEU A 134
ALA A 101
ASP A 102
 None
 1.25A 5ajqB-1b2hA:
undetectable		 5ajqB-1b2hA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgp BARLEY GRAIN
PEROXIDASE

(Hordeum vulgare) 		PF00141
(peroxidase) 		5 ALA A  32
GLY A  42
LEU A  43
ALA A 113
ASP A 116
 None
HEM  A 400 ( 3.9A)
None
None
None
 1.33A 5ajqB-1bgpA:
undetectable		 5ajqB-1bgpA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgp BARLEY GRAIN
PEROXIDASE

(Hordeum vulgare) 		PF00141
(peroxidase) 		5 ALA A  87
ILE A  91
GLY A  42
ALA A 113
ASP A 116
 None
None
HEM  A 400 ( 3.9A)
None
None
 1.33A 5ajqB-1bgpA:
undetectable		 5ajqB-1bgpA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgp BARLEY GRAIN
PEROXIDASE

(Hordeum vulgare) 		PF00141
(peroxidase) 		5 ILE A  91
GLY A  42
LEU A  43
ALA A 113
ASP A 116
 None
HEM  A 400 ( 3.9A)
None
None
None
 1.34A 5ajqB-1bgpA:
undetectable		 5ajqB-1bgpA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 196
GLY A 176
LEU A 180
ALA A 206
ASP A 205
 None
 1.18A 5ajqB-1bxzA:
undetectable		 5ajqB-1bxzA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dg4 DNAK

(Escherichia
coli) 		PF00012
(HSP70) 		5 ILE A 478
PHE A 476
GLY A 400
LEU A 399
ALA A 503
 None
 1.30A 5ajqB-1dg4A:
undetectable		 5ajqB-1dg4A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dr6 DIHYDROFOLATE
REDUCTASE

(Gallus gallus) 		PF00186
(DHFR_1) 		5 ALA A 123
GLY A  53
LEU A  75
ALA A  96
ASP A  95
 NAP  A 191 ( 4.2A)
NAP  A 191 (-3.7A)
NAP  A 191 (-4.3A)
None
None
 1.19A 5ajqB-1dr6A:
undetectable		 5ajqB-1dr6A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		5 ALA A 313
ILE A 312
CYH A 410
GLY A 413
LEU A 409
 None
 1.44A 5ajqB-1e4oA:
undetectable		 5ajqB-1e4oA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE

(Methanopyrus
kandleri) 		PF00296
(Bac_luciferase) 		5 ALA A 186
GLY A  94
LEU A 194
ALA A 227
ASP A 225
 None
 1.49A 5ajqB-1ezwA:
undetectable		 5ajqB-1ezwA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f9n ARGININE
REPRESSOR/ACTIVATOR
PROTEIN

(Bacillus
subtilis) 		PF01316
(Arg_repressor)
PF02863
(Arg_repressor_C) 		4 ALA A 105
ILE A 106
ALA A  83
ASP A  82
 None
 0.43A 5ajqB-1f9nA:
undetectable		 5ajqB-1f9nA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ght TRANSPOSON
GAMMA-DELTA
RESOLVASE

(Escherichia
coli) 		PF00239
(Resolvase) 		5 ILE A  93
GLY A   5
LEU A  23
ALA A  22
ASP A  25
 None
 1.46A 5ajqB-1ghtA:
undetectable		 5ajqB-1ghtA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gwc GLUTATHIONE
S-TRANSFERASE TSI-1

(Aegilops
tauschii) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 ALA A  98
ILE A  97
CYH A 146
GLY A 155
ASP A  91
 None
 1.43A 5ajqB-1gwcA:
undetectable		 5ajqB-1gwcA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  31
PHE A  82
CYH A  83
LEU A 133
ALA A 143
 None
 0.60A 5ajqB-1h4lA:
20.2		 5ajqB-1h4lA:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 ALA A  31
PHE A 204
GLY A  43
LEU A 389
ASP A 391
 None
 1.36A 5ajqB-1hr7A:
undetectable		 5ajqB-1hr7A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i41 CYSTATHIONINE
GAMMA-SYNTHASE

(Nicotiana
tabacum) 		PF01053
(Cys_Met_Meta_PP) 		5 ILE A 235
GLY A 128
LEU A 248
ALA A 252
ASP A 253
 None
 1.42A 5ajqB-1i41A:
undetectable		 5ajqB-1i41A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iho PANTOATE--BETA-ALANI
NE LIGASE

(Escherichia
coli) 		PF02569
(Pantoate_ligase) 		5 ALA A 229
ILE A 243
GLY A 203
LEU A 204
ALA A 267
 None
 1.41A 5ajqB-1ihoA:
undetectable		 5ajqB-1ihoA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 ALA A 220
GLY A 272
LEU A 321
ASP A 332
 None
 0.32A 5ajqB-1k9aA:
24.5		 5ajqB-1k9aA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5a AMIDE SYNTHASE

(Vibrio cholerae) 		PF00668
(Condensation) 		5 ALA A 124
ILE A 105
GLY A 273
LEU A  51
ALA A  54
 None
 1.36A 5ajqB-1l5aA:
undetectable		 5ajqB-1l5aA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1leh LEUCINE
DEHYDROGENASE

(Lysinibacillus
sphaericus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 ALA A  72
ILE A 292
GLY A  77
LEU A  76
ALA A 295
 None
 1.42A 5ajqB-1lehA:
undetectable		 5ajqB-1lehA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF00903
(Glyoxalase) 		5 ALA A  83
ILE A  85
GLY A 166
LEU A 165
ASP A 108
 None
 1.24A 5ajqB-1lkdA:
undetectable		 5ajqB-1lkdA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 606
GLY A 660
LEU A 731
ALA A 741
ASP A 742
 None
 0.61A 5ajqB-1lufA:
23.5		 5ajqB-1lufA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc0 3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 2A

(Mus musculus) 		PF01590
(GAF)
PF13185
(GAF_2) 		5 ILE A 452
GLY A 509
LEU A 428
ALA A 454
ASP A 455
 None
 1.46A 5ajqB-1mc0A:
undetectable		 5ajqB-1mc0A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Escherichia
coli) 		PF00483
(NTP_transferase) 		5 ALA A  89
ILE A  92
PHE A  90
LEU A  50
ALA A  78
 None
 1.25A 5ajqB-1mc3A:
undetectable		 5ajqB-1mc3A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mwo ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 ALA A   1
ILE A 101
GLY A   9
LEU A   6
ASP A 193
 None
 1.45A 5ajqB-1mwoA:
undetectable		 5ajqB-1mwoA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 288
PHE A 336
GLY A 340
LEU A 389
ALA A 399
 P16  A   2 (-3.4A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.68A 5ajqB-1opkA:
23.0		 5ajqB-1opkA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk0 CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA) 		5 ILE A 596
GLY A 306
LEU A 307
ALA A 312
ASP A 313
 None
 1.33A 5ajqB-1pk0A:
undetectable		 5ajqB-1pk0A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE

(Candida
tropicalis) 		PF01575
(MaoC_dehydratas) 		5 ILE A 109
PHE A 132
GLY A 104
ALA A 138
ASP A 139
 None
HDC  A1277 (-3.9A)
None
None
None
 1.49A 5ajqB-1pn4A:
undetectable		 5ajqB-1pn4A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF04166
(PdxA) 		5 ALA A 300
GLY A  18
LEU A  21
ALA A 309
ASP A 310
 None
 1.47A 5ajqB-1ps6A:
undetectable		 5ajqB-1ps6A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pwe L-SERINE DEHYDRATASE

(Rattus
norvegicus) 		PF00291
(PALP) 		5 ILE A 264
CYH A 270
GLY A 271
LEU A 274
ASP A 261
 None
 1.32A 5ajqB-1pweA:
undetectable		 5ajqB-1pweA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzx HYPOTHETICAL PROTEIN
APC36103

(Geobacillus
stearothermophilus) 		PF02645
(DegV) 		5 ALA A 277
ILE A 276
PHE A 161
ALA A 236
ASP A 262
 PLM  A 702 (-3.1A)
None
PLM  A 702 ( 4.2A)
None
None
 1.18A 5ajqB-1pzxA:
undetectable		 5ajqB-1pzxA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2l PROTEASE III

(Escherichia
coli) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF16187
(Peptidase_M16_M) 		5 ALA A  82
GLY A  85
LEU A  86
ALA A 217
ASP A 220
 None
 1.49A 5ajqB-1q2lA:
undetectable		 5ajqB-1q2lA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 ALA A 185
GLY A 250
LEU A 301
ALA A 549
ASP A 550
 ADP  A 810 (-3.3A)
None
ADP  A 810 (-4.7A)
None
ADP  A 810 ( 3.0A)
 0.93A 5ajqB-1q8yA:
22.5		 5ajqB-1q8yA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs0 2-OXOISOVALERATE
DEHYDROGENASE
ALPHA-SUBUNIT

(Pseudomonas
putida) 		PF00676
(E1_dh)
PF12573
(OxoDH_E1alpha_N) 		5 ALA A 207
ILE A 236
PHE A 130
CYH A 129
GLY A 176
 None
 1.18A 5ajqB-1qs0A:
undetectable		 5ajqB-1qs0A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1

(Caenorhabditis
elegans) 		PF00248
(Aldo_ket_red) 		5 ALA A  41
PHE A 274
GLY A  20
LEU A  21
ALA A  34
 None
 1.24A 5ajqB-1qwkA:
undetectable		 5ajqB-1qwkA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 642
CYH A 694
GLY A 697
LEU A 818
ASP A 829
 None
 0.67A 5ajqB-1rjbA:
21.8		 5ajqB-1rjbA:
28.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME

(Arachis
hypogaea) 		PF00141
(peroxidase) 		5 ILE A 100
GLY A  76
LEU A  36
ALA A 104
ASP A 107
 None
 1.48A 5ajqB-1schA:
undetectable		 5ajqB-1schA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32) 		PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ) 		5 ALA A 326
ILE A 330
GLY A 161
LEU A 160
ALA A 332
 None
 1.28A 5ajqB-1t1eA:
undetectable		 5ajqB-1t1eA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 621
CYH A 673
GLY A 676
LEU A 799
 STI  A   3 (-3.5A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
 0.24A 5ajqB-1t46A:
22.1		 5ajqB-1t46A:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twd COPPER HOMEOSTASIS
PROTEIN CUTC

(Shigella
flexneri) 		PF03932
(CutC) 		5 ALA A 175
GLY A 157
LEU A 158
ALA A 190
ASP A 189
 None
 1.32A 5ajqB-1twdA:
undetectable		 5ajqB-1twdA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 367
GLY A 420
LEU A 468
ASP A 479
 STU  A 100 (-3.2A)
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 0.35A 5ajqB-1u59A:
23.6		 5ajqB-1u59A:
27.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 ALA A  55
CYH A 108
GLY A 110
LEU A 158
ASP A 169
 None
 0.52A 5ajqB-1u5qA:
27.0		 5ajqB-1u5qA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua2 CELL DIVISION
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  39
PHE A  93
LEU A 144
ALA A 154
ASP A 155
 ATP  A 381 (-3.6A)
ATP  A 381 (-4.1A)
None
None
ATP  A 381 ( 4.4A)
 1.41A 5ajqB-1ua2A:
24.9		 5ajqB-1ua2A:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uvx GLOBIN LI637

(Chlamydomonas
moewusii) 		PF01152
(Bac_globin) 		5 ILE A 101
GLY A   7
LEU A   6
ALA A 104
ASP A 103
 None
None
XE  A1127 ( 3.8A)
None
None
 1.22A 5ajqB-1uvxA:
undetectable		 5ajqB-1uvxA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmi PUTATIVE PHOSPHATE
ACETYLTRANSFERASE

(Escherichia
coli) 		PF01515
(PTA_PTB) 		5 ALA A 262
GLY A 236
LEU A 238
ALA A 242
ASP A 241
 None
 1.45A 5ajqB-1vmiA:
undetectable		 5ajqB-1vmiA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfu CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA)
PF07737
(ATLF) 		5 ILE A 596
GLY A 306
LEU A 307
ALA A 312
ASP A 313
 None
 1.38A 5ajqB-1xfuA:
undetectable		 5ajqB-1xfuA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xsa BIS(5'-NUCLEOSYL)-TE
TRAPHOSPHATASE

(Homo sapiens) 		PF00293
(NUDIX) 		5 ALA A  68
ILE A  70
GLY A  12
LEU A  13
ALA A 101
 None
 1.33A 5ajqB-1xsaA:
undetectable		 5ajqB-1xsaA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4u CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 ALA A  50
GLY A  61
LEU A  63
ALA A  43
ASP A  44
 None
 1.30A 5ajqB-1y4uA:
undetectable		 5ajqB-1y4uA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO

(Schizosaccharomyces
pombe) 		no annotation 5 ALA A  89
ILE A  56
CYH A  93
LEU A  96
ALA A  65
 None
 1.05A 5ajqB-1yrgA:
undetectable		 5ajqB-1yrgA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY

(Vibrio cholerae) 		PF00480
(ROK) 		5 ALA A 324
ILE A 248
GLY A 223
LEU A 222
ALA A 267
 None
 1.10A 5ajqB-1z05A:
undetectable		 5ajqB-1z05A:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk7 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 414
ILE A 418
GLY A 447
LEU A 448
ALA A 421
 None
 1.32A 5ajqB-1zk7A:
undetectable		 5ajqB-1zk7A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  36
CYH A  87
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-3.5A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.34A 5ajqB-1zltA:
22.7		 5ajqB-1zltA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 PHE B 368
CYH B 369
GLY B 372
ASP B 432
 None
 0.43A 5ajqB-2a1aB:
21.5		 5ajqB-2a1aB:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8n CYTIDINE AND
DEOXYCYTIDYLATE
DEAMINASE

(Agrobacterium
tumefaciens) 		PF14437
(MafB19-deam) 		5 ALA A  38
ILE A  37
LEU A  71
ALA A  74
ASP A  75
 None
 1.28A 5ajqB-2a8nA:
undetectable		 5ajqB-2a8nA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5u COLICIN E3

(Escherichia
coli) 		PF03515
(Cloacin)
PF09000
(Cytotoxic)
PF11570
(E2R135) 		5 ALA A 211
ILE A 272
PHE A 220
GLY A 279
ALA A 282
 None
 1.08A 5ajqB-2b5uA:
undetectable		 5ajqB-2b5uA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bas YKUI PROTEIN

(Bacillus
subtilis) 		PF00563
(EAL)
PF10388
(YkuI_C) 		5 ALA A 165
ILE A 202
LEU A 172
ALA A 204
ASP A 170
 None
 1.33A 5ajqB-2basA:
undetectable		 5ajqB-2basA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdw HYPOTHETICAL PROTEIN
K11E8.1D

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		4 GLY A  95
LEU A 142
ALA A 155
ASP A 156
 None
 0.35A 5ajqB-2bdwA:
22.8		 5ajqB-2bdwA:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bju PLASMEPSIN II

(Plasmodium
falciparum) 		PF00026
(Asp) 		5 ILE A   6
PHE A 154
GLY A 125
LEU A 124
ALA A  20
 None
 1.25A 5ajqB-2bjuA:
undetectable		 5ajqB-2bjuA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  47
PHE A 100
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-3.6A)
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.66A 5ajqB-2bujA:
25.3		 5ajqB-2bujA:
28.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459) 		5 ALA A 180
GLY A  99
LEU A  96
ALA A  93
ASP A  90
 None
 0.94A 5ajqB-2bxyA:
2.2		 5ajqB-2bxyA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csn CASEIN KINASE-1

(Schizosaccharomyces
pombe) 		PF00069
(Pkinase) 		5 ALA A  39
ILE A  85
GLY A  89
LEU A 138
ASP A 154
 CKI  A 300 (-3.6A)
CKI  A 300 ( 4.5A)
None
CKI  A 300 (-4.4A)
CKI  A 300 (-4.4A)
 1.13A 5ajqB-2csnA:
21.9		 5ajqB-2csnA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1f THREONINE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		5 ALA A 275
GLY A 225
LEU A 224
ALA A 309
ASP A 312
 None
 1.29A 5ajqB-2d1fA:
undetectable		 5ajqB-2d1fA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA X  37
GLY X  88
LEU X 137
ALA X 147
ASP X 148
 STU  X 902 (-3.1A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
STU  X 902 (-3.6A)
 0.27A 5ajqB-2dq7X:
24.4		 5ajqB-2dq7X:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvz PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03401
(TctC) 		5 ALA A  28
PHE A  27
GLY A 150
ALA A 181
ASP A 184
 None
GLU  A1055 (-3.7A)
None
None
None
 1.28A 5ajqB-2dvzA:
undetectable		 5ajqB-2dvzA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eja UROPORPHYRINOGEN
DECARBOXYLASE

(Aquifex
aeolicus) 		PF01208
(URO-D) 		5 ILE A 198
PHE A 237
LEU A 256
ALA A 253
ASP A 254
 None
 1.50A 5ajqB-2ejaA:
undetectable		 5ajqB-2ejaA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eja UROPORPHYRINOGEN
DECARBOXYLASE

(Aquifex
aeolicus) 		PF01208
(URO-D) 		5 ILE A 223
GLY A 274
LEU A 256
ALA A 248
ASP A 250
 None
 1.45A 5ajqB-2ejaA:
undetectable		 5ajqB-2ejaA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 184
GLY A 240
LEU A 290
ALA A 319
ASP A 320
 None
 0.88A 5ajqB-2eu9A:
23.4		 5ajqB-2eu9A:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5x RIBOSOME-INACTIVATIN
G PROTEIN

(Silene
chalcedonica) 		PF00161
(RIP) 		5 ALA A 171
ILE A 177
GLY A 136
LEU A 135
ALA A 192
 None
 1.30A 5ajqB-2g5xA:
undetectable		 5ajqB-2g5xA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8l 287AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF01937
(DUF89) 		5 ALA A 165
ILE A 166
GLY A 159
ALA A  86
ASP A  87
 None
 1.07A 5ajqB-2g8lA:
undetectable		 5ajqB-2g8lA:
23.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 ALA A  55
CYH A 108
GLY A 110
LEU A 158
ASP A 169
 STU  A 400 (-3.2A)
STU  A 400 (-4.0A)
STU  A 400 (-3.4A)
STU  A 400 ( 4.6A)
STU  A 400 (-3.6A)
 0.45A 5ajqB-2gcdA:
25.5		 5ajqB-2gcdA:
36.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR

(Mycobacterium
tuberculosis) 		PF02515
(CoA_transf_3) 		5 ALA A  70
ILE A  36
GLY A  93
LEU A  92
ASP A  60
 None
None
None
CAA  A1751 (-4.2A)
CAA  A1751 ( 4.7A)
 1.43A 5ajqB-2gd2A:
undetectable		 5ajqB-2gd2A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 293
GLY A 344
LEU A 393
ALA A 403
ASP A 404
 H8H  A 534 (-3.2A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
H8H  A 534 (-4.2A)
 0.23A 5ajqB-2h8hA:
24.4		 5ajqB-2h8hA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 293
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.40A 5ajqB-2hckA:
23.6		 5ajqB-2hckA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 ALA A 659
PHE A 709
GLY A 713
LEU A 761
 ADP  A 400 (-3.2A)
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.29A 5ajqB-2henA:
20.0		 5ajqB-2henA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT

(Streptococcus
mutans) 		PF04223
(CitF) 		5 ALA A 169
ILE A 205
GLY A 191
ALA A 197
ASP A 224
 None
 1.37A 5ajqB-2hj0A:
undetectable		 5ajqB-2hj0A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 271
PHE A 318
GLY A 322
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 (-3.6A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.73A 5ajqB-2hk5A:
24.0		 5ajqB-2hk5A:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 269
PHE A 317
GLY A 321
LEU A 370
ALA A 380
ASP A 381
 GIN  A 600 (-3.1A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.58A 5ajqB-2hz0A:
23.8		 5ajqB-2hz0A:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iie INTEGRATION HOST
FACTOR

(Escherichia
coli) 		PF00216
(Bac_DNA_binding) 		5 ALA A  13
ILE A   9
LEU A  70
ALA A  27
ASP A  26
 None
 1.17A 5ajqB-2iieA:
undetectable		 5ajqB-2iieA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iop CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 ALA A  50
GLY A  61
LEU A  63
ALA A  43
ASP A  44
 None
 1.27A 5ajqB-2iopA:
undetectable		 5ajqB-2iopA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ior CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF02518
(HATPase_c) 		5 ALA A  50
GLY A  61
LEU A  63
ALA A  43
ASP A  44
 None
 1.28A 5ajqB-2iorA:
undetectable		 5ajqB-2iorA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Pyrococcus
abyssi) 		PF00814
(Peptidase_M22) 		5 ALA A 157
ILE A 154
GLY A 201
LEU A 202
ALA A 228
 None
 1.35A 5ajqB-2ivpA:
undetectable		 5ajqB-2ivpA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ALA A 300
ILE A 456
GLY A  48
LEU A 283
ALA A 395
 None
 1.32A 5ajqB-2iwzA:
undetectable		 5ajqB-2iwzA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		5 ALA A 452
CYH A 502
GLY A 505
LEU A 553
ASP A 564
 4ST  A1687 (-3.3A)
4ST  A1687 (-4.1A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.46A 5ajqB-2j0jA:
23.3		 5ajqB-2j0jA:
19.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  31
PHE A  82
LEU A 134
ALA A 144
ASP A 145
 None
 0.64A 5ajqB-2jgzA:
24.4		 5ajqB-2jgzA:
31.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 ALA A 452
CYH A 502
GLY A 505
LEU A 553
 BII  A1687 (-3.5A)
BII  A1687 (-4.1A)
BII  A1687 (-3.6A)
BII  A1687 (-4.2A)
 0.27A 5ajqB-2jkmA:
23.4		 5ajqB-2jkmA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l0r LETHAL FACTOR

(Bacillus
anthracis) 		PF07737
(ATLF) 		5 ILE A  47
PHE A  48
GLY A  59
LEU A  55
ALA A  89
 None
 1.46A 5ajqB-2l0rA:
undetectable		 5ajqB-2l0rA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mrm MEMBRANE PROTEIN

(Escherichia
coli) 		PF00581
(Rhodanese) 		5 ALA A  99
GLY A  92
LEU A  89
ALA A  11
ASP A  10
 None
 1.09A 5ajqB-2mrmA:
undetectable		 5ajqB-2mrmA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nc8 LIPOPROTEIN LPPM

(Mycobacterium
tuberculosis) 		no annotation 5 ALA A  85
ILE A  44
GLY A  82
ALA A 105
ASP A 104
 None
 1.22A 5ajqB-2nc8A:
undetectable		 5ajqB-2nc8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqo GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Helicobacter
pylori) 		PF01019
(G_glu_transpept) 		5 ALA A  67
ILE A  68
GLY A  59
LEU A  55
ALA A  40
 None
 1.31A 5ajqB-2nqoA:
undetectable		 5ajqB-2nqoA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind)
PF13416
(SBP_bac_8) 		5 ILE B1162
PHE B1259
GLY B1328
ALA B1164
ASP B1165
 None
 1.38A 5ajqB-2nvuB:
undetectable		 5ajqB-2nvuB:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 ILE A 423
PHE A 391
GLY A 360
LEU A 431
ALA A 429
 ILE  A 423 ( 0.7A)
PHE  A 391 ( 1.3A)
GLY  A 360 ( 0.0A)
LEU  A 431 ( 0.6A)
ALA  A 429 ( 0.0A)
 1.41A 5ajqB-2nvvA:
undetectable		 5ajqB-2nvvA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE

(Rhodobacter
sphaeroides) 		PF00221
(Lyase_aromatic) 		5 ALA A 373
ILE A 459
GLY A 223
LEU A 222
ALA A 457
 None
 1.18A 5ajqB-2o78A:
undetectable		 5ajqB-2o78A:
21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 614
CYH A 666
GLY A 669
LEU A 785
ASP A 796
 None
 0.61A 5ajqB-2ogvA:
15.5		 5ajqB-2ogvA:
32.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozh HYPOTHETICAL PROTEIN
XCC2953

(Xanthomonas
campestris) 		PF13508
(Acetyltransf_7) 		5 ALA A  59
PHE A  58
GLY A  49
ALA A  92
ASP A  91
 None
 1.46A 5ajqB-2ozhA:
undetectable		 5ajqB-2ozhA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 853
ILE A 902
GLY A 908
LEU A 971
ALA A 981
 MR9  A 301 (-3.5A)
MR9  A 301 (-4.1A)
MR9  A 301 ( 3.8A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
 0.67A 5ajqB-2p4iA:
19.1		 5ajqB-2p4iA:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 515
GLY A 570
LEU A 633
ALA A 643
 None
 0.40A 5ajqB-2psqA:
23.9		 5ajqB-2psqA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		4 ALA B  67
GLY B 120
LEU B 171
ASP B 182
 None
 0.34A 5ajqB-2qkwB:
20.7		 5ajqB-2qkwB:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 215
GLY A 271
LEU A 328
ALA A 338
ASP A 339
 ADE  A 488 (-3.2A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
None
 0.54A 5ajqB-2qluA:
22.5		 5ajqB-2qluA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 215
PHE A 267
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.54A 5ajqB-2qluA:
22.5		 5ajqB-2qluA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE

(Corynebacterium
glutamicum) 		PF00478
(IMPDH) 		5 ILE A  77
GLY A  73
LEU A  74
ALA A 140
ASP A 161
 None
 1.42A 5ajqB-2qr6A:
undetectable		 5ajqB-2qr6A:
23.63