SIMILAR PATTERNS OF AMINO ACIDS FOR 5AJQ_A_DB8A800

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 267
ALA A 288
LYS A 290
PHE A 336
GLY A 340
LEU A 389
ALA A 399
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 1.04A 5ajqA-1opkA:
22.7		 5ajqA-1opkA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 267
GLY A 268
ALA A 288
PHE A 336
GLY A 340
LEU A 389
ALA A 399
 P16  A   2 ( 4.2A)
P16  A   2 ( 4.3A)
P16  A   2 (-3.4A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.98A 5ajqA-1opkA:
22.7		 5ajqA-1opkA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 LEU A 164
ALA A 185
GLY A 250
LEU A 301
ALA A 549
ASP A 550
 ADP  A 810 ( 4.3A)
ADP  A 810 (-3.3A)
None
ADP  A 810 (-4.7A)
None
ADP  A 810 ( 3.0A)
 0.90A 5ajqA-1q8yA:
17.0		 5ajqA-1q8yA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
ALA A 642
LYS A 644
CYH A 694
GLY A 697
LEU A 818
ASP A 829
 None
 1.35A 5ajqA-1rjbA:
21.6		 5ajqA-1rjbA:
28.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
ALA A 642
CYH A 694
GLY A 697
LEU A 818
ASP A 829
 None
 0.93A 5ajqA-1rjbA:
21.6		 5ajqA-1rjbA:
28.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 595
ALA A 621
LYS A 623
CYH A 673
GLY A 676
LEU A 799
 STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
 0.86A 5ajqA-1t46A:
22.5		 5ajqA-1t46A:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
ALA A  36
CYH A  87
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.54A 5ajqA-1zltA:
22.2		 5ajqA-1zltA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  26
ALA A  47
PHE A 100
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-3.6A)
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.82A 5ajqA-2bujA:
24.7		 5ajqA-2bujA:
28.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU X  17
ALA X  37
GLY X  88
LEU X 137
ALA X 147
ASP X 148
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
STU  X 902 (-3.6A)
 0.58A 5ajqA-2dq7X:
23.6		 5ajqA-2dq7X:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
ALA A 293
GLY A 344
LEU A 393
ALA A 403
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
H8H  A 534 (-4.2A)
 0.50A 5ajqA-2h8hA:
25.0		 5ajqA-2h8hA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
ALA A 293
LYS A 295
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.79A 5ajqA-2h8hA:
25.0		 5ajqA-2h8hA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
GLY A 274
ALA A 293
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.87A 5ajqA-2h8hA:
25.0		 5ajqA-2h8hA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
ALA A 293
LYS A 295
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.85A 5ajqA-2hckA:
24.3		 5ajqA-2hckA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
GLY A 274
ALA A 293
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 (-3.5A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.85A 5ajqA-2hckA:
24.3		 5ajqA-2hckA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
GLY A 252
ALA A 271
PHE A 318
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
None
1BM  A 499 (-3.6A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.83A 5ajqA-2hk5A:
23.3		 5ajqA-2hk5A:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
GLY A 252
PHE A 318
GLY A 322
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 3.7A)
None
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.99A 5ajqA-2hk5A:
23.3		 5ajqA-2hk5A:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 248
ALA A 269
LYS A 271
PHE A 317
GLY A 321
LEU A 370
ASP A 381
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-4.9A)
 1.16A 5ajqA-2hz0A:
23.4		 5ajqA-2hz0A:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 248
ALA A 269
PHE A 317
GLY A 321
LEU A 370
ALA A 380
ASP A 381
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.65A 5ajqA-2hz0A:
23.4		 5ajqA-2hz0A:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 248
GLY A 249
ALA A 269
PHE A 317
GLY A 321
LEU A 370
 GIN  A 600 ( 4.6A)
None
GIN  A 600 (-3.1A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
 0.84A 5ajqA-2hz0A:
23.4		 5ajqA-2hz0A:
29.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 588
GLY A 589
ALA A 614
CYH A 666
GLY A 669
LEU A 785
 None
 0.74A 5ajqA-2ogvA:
21.2		 5ajqA-2ogvA:
32.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 724
ALA A 749
GLY A 802
GLU A 810
LEU A 850
ASP A 861
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.6A)
None
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.89A 5ajqA-2r4bA:
24.1		 5ajqA-2r4bA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 724
ALA A 749
LYS A 751
GLY A 802
GLU A 810
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-3.6A)
None
GW7  A   1 (-4.2A)
 0.84A 5ajqA-2r4bA:
24.1		 5ajqA-2r4bA:
26.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  68
ALA A  92
LYS A  94
PHE A 143
GLY A 147
LEU A 194
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.81A 5ajqA-2z7rA:
25.1		 5ajqA-2z7rA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  68
ALA A  92
PHE A 143
GLY A 147
LEU A 194
ASP A 205
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.65A 5ajqA-2z7rA:
25.1		 5ajqA-2z7rA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  68
GLY A  69
ALA A  92
PHE A 143
GLY A 147
LEU A 194
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
STU  A   1 (-3.3A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.88A 5ajqA-2z7rA:
25.1		 5ajqA-2z7rA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 253
GLY A 254
ALA A 273
PHE A 321
GLY A 325
LEU A 374
ALA A 384
 None
 0.82A 5ajqA-2zv7A:
24.2		 5ajqA-2zv7A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 253
GLY A 254
PHE A 321
GLY A 325
LEU A 374
ALA A 384
ASP A 385
 None
 0.98A 5ajqA-2zv7A:
24.2		 5ajqA-2zv7A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 487
ALA A 515
LYS A 517
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.79A 5ajqA-3b2tA:
18.6		 5ajqA-3b2tA:
29.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 487
GLY A 488
ALA A 515
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.77A 5ajqA-3b2tA:
18.6		 5ajqA-3b2tA:
29.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 484
ALA A 512
GLY A 567
LEU A 630
ALA A 640
ASP A 641
 C4F  A   1 ( 3.9A)
C4F  A   1 (-3.3A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-4.5A)
 0.82A 5ajqA-3c4fA:
22.7		 5ajqA-3c4fA:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  26
ALA A  46
PHE A 105
CYH A 106
LEU A 156
ALA A 166
ASP A 167
 None
 0.63A 5ajqA-3mi9A:
25.2		 5ajqA-3mi9A:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 209
ALA A 227
GLY A 283
LEU A 337
ALA A 347
ASP A 348
 None
LDN  A 600 (-3.2A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.76A 5ajqA-3my0A:
16.6		 5ajqA-3my0A:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 217
PHE A 269
GLY A 273
LEU A 329
ALA A 339
ASP A 340
 TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
None
 0.69A 5ajqA-3q4tA:
22.2		 5ajqA-3q4tA:
23.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 361
ALA A 382
PHE A 435
LEU A 486
ALA A 496
ASP A 497
 07U  A   1 ( 4.8A)
07U  A   1 (-3.3A)
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
07U  A   1 (-3.6A)
 0.64A 5ajqA-3txoA:
16.1		 5ajqA-3txoA:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 361
PHE A 435
GLY A 439
LEU A 486
ALA A 496
ASP A 497
 07U  A   1 ( 4.8A)
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
07U  A   1 (-3.6A)
 0.73A 5ajqA-3txoA:
16.1		 5ajqA-3txoA:
30.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
GLY A 841
ALA A 866
PHE A 918
CYH A 919
GLY A 922
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.8A)
4TT  A2001 (-3.5A)
4TT  A2001 (-4.5A)
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
 0.89A 5ajqA-3vidA:
21.1		 5ajqA-3vidA:
26.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 139
ALA A 160
LYS A 162
GLY A 216
LEU A 263
ALA A 273
 N13  A 501 (-3.7A)
N13  A 501 ( 4.1A)
N13  A 501 (-2.9A)
N13  A 501 (-3.5A)
N13  A 501 (-4.5A)
N13  A 501 ( 3.8A)
 0.82A 5ajqA-3w18A:
24.4		 5ajqA-3w18A:
33.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 840
GLY A 841
ALA A 866
LYS A 868
PHE A 918
CYH A 919
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.1A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-4.1A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.75A 5ajqA-3wzdA:
22.5		 5ajqA-3wzdA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
LYS A 868
PHE A 918
CYH A 919
GLY A 922
LEU A1035
ASP A1046
 LEV  A1201 ( 3.8A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-4.1A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.94A 5ajqA-3wzdA:
22.5		 5ajqA-3wzdA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 626
ALA A 649
PHE A 699
GLY A 703
LEU A 751
ASP A 762
 None
 0.79A 5ajqA-3zfxA:
24.7		 5ajqA-3zfxA:
28.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  83
ALA A 104
LYS A 106
GLY A 160
LEU A 207
ALA A 217
 VX6  A 500 (-3.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-3.3A)
VX6  A 500 (-3.3A)
VX6  A 500 (-4.6A)
VX6  A 500 ( 4.2A)
 0.58A 5ajqA-4af3A:
22.4		 5ajqA-4af3A:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  83
GLY A  84
ALA A 104
GLY A 160
LEU A 207
ALA A 217
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.1A)
VX6  A 500 (-3.4A)
VX6  A 500 (-3.3A)
VX6  A 500 (-4.6A)
VX6  A 500 ( 4.2A)
 0.77A 5ajqA-4af3A:
22.4		 5ajqA-4af3A:
30.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
ALA A 866
LYS A 868
PHE A 918
GLY A 922
LEU A1035
 B49  A2000 (-3.7A)
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.88A 5ajqA-4agdA:
21.3		 5ajqA-4agdA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
GLY A 841
ALA A 866
PHE A 918
CYH A 919
GLY A 922
LEU A1035
 B49  A2000 (-3.7A)
B49  A2000 ( 4.6A)
B49  A2000 (-3.5A)
B49  A2000 (-4.4A)
B49  A2000 (-4.2A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.76A 5ajqA-4agdA:
21.3		 5ajqA-4agdA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
GLY A 841
PHE A 918
CYH A 919
GLY A 922
LEU A1035
ASP A1046
 B49  A2000 (-3.7A)
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
B49  A2000 (-4.2A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
None
 0.96A 5ajqA-4agdA:
21.3		 5ajqA-4agdA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 560
GLY A 561
ALA A 586
GLY A 639
LEU A 699
ASP A 710
 LTI  A1839 ( 4.2A)
LTI  A1839 ( 4.3A)
LTI  A1839 (-3.3A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
None
 0.81A 5ajqA-4at3A:
25.1		 5ajqA-4at3A:
26.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  42
ALA A  63
PHE A 112
CYH A 113
GLY A 116
GLU A 124
LEU A 164
ALA A 174
 XZN  A1317 (-3.6A)
XZN  A1317 (-3.5A)
XZN  A1317 (-4.5A)
XZN  A1317 (-3.7A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-3.3A)
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 0.47A 5ajqA-4bc6A:
35.4		 5ajqA-4bc6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  42
GLY A  43
ALA A  63
LYS A  65
PHE A 112
CYH A 113
GLY A 116
LEU A 164
ALA A 174
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.9A)
XZN  A1317 (-3.5A)
XZN  A1317 (-4.1A)
XZN  A1317 (-4.5A)
XZN  A1317 (-3.7A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 0.84A 5ajqA-4bc6A:
35.4		 5ajqA-4bc6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 LEU A  22
ALA A  43
GLY A  99
LEU A 146
ALA A 156
ASP A 157
 STU  A1550 (-4.3A)
STU  A1550 (-3.1A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
STU  A1550 (-3.6A)
 0.82A 5ajqA-4cfhA:
24.5		 5ajqA-4cfhA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 663
ALA A 684
GLY A 743
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.53A 5ajqA-4crsA:
24.8		 5ajqA-4crsA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
ALA A  36
LYS A  38
PHE A  88
CYH A  89
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-4.1A)
BX7  A 401 (-3.5A)
 0.83A 5ajqA-4eutA:
20.3		 5ajqA-4eutA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
ALA A  36
PHE A  88
CYH A  89
GLY A  92
ASP A 157
 BX7  A 401 (-3.9A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-4.1A)
BX7  A 401 (-3.3A)
BX7  A 401 (-3.6A)
 0.75A 5ajqA-4euuA:
17.1		 5ajqA-4euuA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 514
GLY A 515
ALA A 538
PHE A 595
GLY A 599
ALA A 662
ASP A 663
 0T8  A 901 (-3.6A)
0T8  A 901 ( 3.9A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
 0.71A 5ajqA-4feqA:
23.0		 5ajqA-4feqA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A1122
GLY A1123
ALA A1148
GLY A1202
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 ( 4.3A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.78A 5ajqA-4fodA:
22.8		 5ajqA-4fodA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 828
ALA A 853
LYS A 855
GLY A 908
LEU A 956
ALA A 966
ASP A 967
 19S  A1201 (-3.9A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
19S  A1201 ( 4.1A)
 1.21A 5ajqA-4hviA:
22.7		 5ajqA-4hviA:
29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		6 LEU A  15
ALA A  36
PHE A  88
CYH A  89
GLY A  92
ASP A 157
 SU6  A 701 (-3.6A)
SU6  A 701 (-3.4A)
SU6  A 701 (-4.0A)
SU6  A 701 (-3.8A)
SU6  A 701 (-3.8A)
None
 0.73A 5ajqA-4jlcA:
19.1		 5ajqA-4jlcA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  18
ALA A  39
LYS A  41
CYH A  92
GLY A  95
LEU A 143
ALA A 153
 631  A 301 (-3.4A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
631  A 301 (-4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
631  A 301 (-3.4A)
 0.70A 5ajqA-4jxfA:
21.4		 5ajqA-4jxfA:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  18
GLY A  19
ALA A  39
CYH A  92
GLY A  95
LEU A 143
ALA A 153
 631  A 301 (-3.4A)
631  A 301 (-3.6A)
631  A 301 (-3.3A)
631  A 301 (-4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
631  A 301 (-3.4A)
 0.72A 5ajqA-4jxfA:
21.4		 5ajqA-4jxfA:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  18
GLY A  19
CYH A  92
GLY A  95
LEU A 143
ALA A 153
ASP A 154
 631  A 301 (-3.4A)
631  A 301 (-3.6A)
631  A 301 (-4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
631  A 301 (-3.4A)
EDO  A 302 (-3.7A)
 0.92A 5ajqA-4jxfA:
21.4		 5ajqA-4jxfA:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
ALA A 293
GLY A 344
LEU A 393
ALA A 403
ASP A 404
 0J9  A 601 (-4.0A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
0J9  A 601 (-3.5A)
0J9  A 601 (-3.1A)
 0.84A 5ajqA-4k11A:
24.5		 5ajqA-4k11A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
GLY A 274
ALA A 293
GLY A 344
LEU A 393
ALA A 403
 0J9  A 601 (-4.0A)
0J9  A 601 ( 4.0A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
0J9  A 601 (-3.5A)
 0.85A 5ajqA-4k11A:
24.5		 5ajqA-4k11A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 478
ALA A 506
GLY A 561
LEU A 624
ALA A 634
ASP A 635
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.6A)
ACP  A 801 (-4.4A)
None
MG  A 802 ( 3.0A)
 0.66A 5ajqA-4k33A:
18.7		 5ajqA-4k33A:
27.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  33
ALA A  54
LYS A  56
CYH A 102
GLY A 105
LEU A 153
ALA A 163
 GOL  A 404 ( 3.6A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
GOL  A 403 (-4.0A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
GOL  A 403 ( 3.0A)
 1.04A 5ajqA-4lg4A:
29.5		 5ajqA-4lg4A:
40.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  33
GLY A  34
ALA A  54
CYH A 102
GLY A 105
LEU A 153
ALA A 163
 GOL  A 404 ( 3.6A)
None
GOL  A 404 ( 3.1A)
GOL  A 403 (-4.0A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
GOL  A 403 ( 3.0A)
 0.90A 5ajqA-4lg4A:
29.5		 5ajqA-4lg4A:
40.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 273
GLY A 274
ALA A 293
GLY A 344
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.8A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.71A 5ajqA-4lggA:
22.9		 5ajqA-4lggA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  78
GLY A  79
ALA A  99
CYH A 149
GLY A 151
LEU A 199
ASP A 213
 STU  A 601 ( 4.0A)
STU  A 601 (-3.6A)
STU  A 601 (-3.3A)
STU  A 601 (-4.2A)
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
STU  A 601 (-4.3A)
 0.96A 5ajqA-4mvfA:
22.2		 5ajqA-4mvfA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  46
ALA A  67
LYS A  69
CYH A 126
GLY A 128
LEU A 180
ASP A 191
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 1.05A 5ajqA-4o38A:
21.0		 5ajqA-4o38A:
27.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 627
ALA A 648
GLY A 707
LEU A 753
ALA A 763
ASP A 764
 None
 0.63A 5ajqA-4otdA:
24.7		 5ajqA-4otdA:
31.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
GLY A 617
ALA A 642
CYH A 694
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.70A 5ajqA-4rt7A:
22.3		 5ajqA-4rt7A:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 LEU A  14
ALA A  35
LYS A  37
GLY A  87
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
None
 1.01A 5ajqA-4ueuA:
24.0		 5ajqA-4ueuA:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 LEU A  14
GLY A  15
ALA A  35
GLY A  87
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.2A)
ACP  A1264 (-2.9A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
None
 1.04A 5ajqA-4ueuA:
24.0		 5ajqA-4ueuA:
26.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  40
GLY A  41
ALA A  61
LYS A  63
PHE A 110
CYH A 111
GLY A 114
LEU A 162
ALA A 172
 6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.5A)
6UI  A 700 (-4.3A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
 0.78A 5ajqA-4usfA:
36.2		 5ajqA-4usfA:
75.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  52
ALA A  72
PHE A 128
CYH A 129
GLY A 132
LEU A 183
ASP A 194
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
KSA  A 405 (-4.8A)
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.56A 5ajqA-4wsqA:
23.1		 5ajqA-4wsqA:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 LEU B 267
ALA B 288
LYS B 290
PHE B 336
GLY B 340
LEU B 389
 1N1  B 601 (-3.7A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 ( 4.2A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
 0.76A 5ajqA-4xeyB:
23.3		 5ajqA-4xeyB:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 LEU B 267
ALA B 288
PHE B 336
GLY B 340
LEU B 389
ALA B 399
 1N1  B 601 (-3.7A)
1N1  B 601 (-3.5A)
1N1  B 601 ( 4.2A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
 0.76A 5ajqA-4xeyB:
23.3		 5ajqA-4xeyB:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
GLY A 617
ALA A 642
CYH A 694
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.71A 5ajqA-4xufA:
22.7		 5ajqA-4xufA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 484
ALA A 512
GLY A 567
LEU A 630
ALA A 640
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 (-3.6A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
38O  A1769 (-4.0A)
 0.82A 5ajqA-5a46A:
22.0		 5ajqA-5a46A:
27.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		7 LEU A  99
ALA A 120
LYS A 122
PHE A 172
GLY A 176
LEU A 223
ALA A 233
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
 0.81A 5ajqA-5eykA:
25.2		 5ajqA-5eykA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		7 LEU A  99
GLY A 100
ALA A 120
PHE A 172
GLY A 176
LEU A 223
ALA A 233
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.8A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
 0.81A 5ajqA-5eykA:
25.2		 5ajqA-5eykA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		7 LEU A  99
GLY A 100
PHE A 172
GLY A 176
LEU A 223
ALA A 233
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.8A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
None
 0.98A 5ajqA-5eykA:
25.2		 5ajqA-5eykA:
31.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 599
ALA A 625
LYS A 627
CYH A 677
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.82A 5ajqA-5grnA:
3.3		 5ajqA-5grnA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 599
GLY A 600
ALA A 625
CYH A 677
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
None
748  A1001 (-3.7A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.88A 5ajqA-5grnA:
3.3		 5ajqA-5grnA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		6 LEU A  20
ALA A  41
GLY A  96
LEU A 143
ALA A 156
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.5A)
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
MG  A 302 ( 3.3A)
 0.60A 5ajqA-5hu3A:
26.1		 5ajqA-5hu3A:
29.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  57
ALA A  77
CYH A 133
GLY A 136
LEU A 187
ASP A 198
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-4.0A)
 0.54A 5ajqA-5i3oA:
23.2		 5ajqA-5i3oA:
30.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 LEU A  22
ALA A  43
GLY A  99
LEU A 146
ALA A 156
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.0A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
STU  A 601 (-3.5A)
 0.90A 5ajqA-5isoA:
24.0		 5ajqA-5isoA:
19.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  43
LYS A  45
PHE A  92
CYH A  93
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
6G2  A 901 (-4.1A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.97A 5ajqA-5j5tA:
30.0		 5ajqA-5j5tA:
36.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  43
PHE A  92
CYH A  93
GLY A  96
LEU A 143
ALA A 153
ASP A 154
 6G2  A 901 (-3.2A)
6G2  A 901 (-4.1A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
6G2  A 901 (-3.4A)
 0.49A 5ajqA-5j5tA:
30.0		 5ajqA-5j5tA:
36.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  23
ALA A  43
PHE A  92
CYH A  93
GLY A  96
LEU A 143
 None
6G2  A 901 (-3.2A)
6G2  A 901 (-4.1A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.66A 5ajqA-5j5tA:
30.0		 5ajqA-5j5tA:
36.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 593
GLY A 594
ALA A 617
PHE A 673
GLY A 677
ALA A 740
ASP A 741
 7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.2A)
7AE  A1000 (-3.3A)
7AE  A1000 (-4.1A)
7AE  A1000 ( 3.7A)
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
 1.04A 5ajqA-5td2A:
17.8		 5ajqA-5td2A:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 542
ALA A 565
LYS A 567
PHE A 622
GLY A 626
ALA A 689
ASP A 690
 7YS  A9001 (-4.1A)
7YS  A9001 (-3.3A)
None
7YS  A9001 (-4.3A)
7YS  A9001 (-3.4A)
7YS  A9001 (-3.4A)
None
 1.05A 5ajqA-5u6bA:
25.2		 5ajqA-5u6bA:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 542
GLY A 543
ALA A 565
PHE A 622
GLY A 626
ALA A 689
ASP A 690
 7YS  A9001 (-4.1A)
7YS  A9001 ( 4.2A)
7YS  A9001 (-3.3A)
7YS  A9001 (-4.3A)
7YS  A9001 (-3.4A)
7YS  A9001 (-3.4A)
None
 0.87A 5ajqA-5u6bA:
25.2		 5ajqA-5u6bA:
28.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vo1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 12

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 150
LYS A 152
PHE A 192
CYH A 193
GLY A 196
LEU A 243
ASP A 254
 9FS  A 501 (-3.4A)
None
9FS  A 501 (-4.3A)
9FS  A 501 (-4.3A)
9FS  A 501 (-3.6A)
9FS  A 501 (-4.7A)
None
 1.31A 5ajqA-5vo1A:
23.2		 5ajqA-5vo1A:
31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vo1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 12

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 132
ALA A 150
PHE A 192
CYH A 193
GLY A 196
LEU A 243
ASP A 254
 9FS  A 501 (-3.7A)
9FS  A 501 (-3.4A)
9FS  A 501 (-4.3A)
9FS  A 501 (-4.3A)
9FS  A 501 (-3.6A)
9FS  A 501 (-4.7A)
None
 0.81A 5ajqA-5vo1A:
23.2		 5ajqA-5vo1A:
31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 7 LEU A  33
ALA A  54
LYS A  56
CYH A 102
GLY A 105
LEU A 153
ALA A 163
 ANP  A 501 ( 3.8A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-2.4A)
ANP  A 501 (-4.2A)
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
None
 0.72A 5ajqA-6ao5A:
31.7		 5ajqA-6ao5A:
36.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 7 LEU A  33
GLY A  34
ALA A  54
CYH A 102
GLY A 105
LEU A 153
ALA A 163
 ANP  A 501 ( 3.8A)
ANP  A 501 ( 3.9A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-4.2A)
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
None
 0.61A 5ajqA-6ao5A:
31.7		 5ajqA-6ao5A:
36.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 LEU A 881
ALA A 906
PHE A 958
GLY A 962
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.66A 5ajqA-6c7yA:
22.8		 5ajqA-6c7yA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 LEU A 881
GLY A 882
ALA A 906
PHE A 958
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-3.4A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.72A 5ajqA-6c7yA:
22.8		 5ajqA-6c7yA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 8 LEU U  20
ALA U  42
PHE U  93
CYH U  94
GLY U  97
LEU U 144
ALA U 156
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 (-4.2A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.57A 5ajqA-6fdyU:
21.1		 5ajqA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 8 LEU U  20
GLY U  21
ALA U  42
PHE U  93
CYH U  94
LEU U 144
ALA U 156
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.9A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 (-4.2A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.84A 5ajqA-6fdyU:
21.1		 5ajqA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 6 LYS U  44
CYH U  94
GLY U  97
LEU U 144
ALA U 156
ASP U 157
 DB8  U 301 ( 4.0A)
DB8  U 301 (-4.2A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.76A 5ajqA-6fdyU:
21.1		 5ajqA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c6v PROTEIN (SIV
INTEGRASE)

(Simian
immunodeficiency
virus) 		PF00665
(rve) 		4 VAL A 180
ILE A 162
ASN A 155
VAL A  73
 None
 1.27A 5ajqA-1c6vA:
undetectable		 5ajqA-1c6vA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6t RIBONUCLEASE P

(Staphylococcus
aureus) 		PF00825
(Ribonuclease_P) 		4 VAL A  25
ILE A  18
ASN A  37
VAL A 111
 None
 1.32A 5ajqA-1d6tA:
undetectable		 5ajqA-1d6tA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 VAL A 228
ILE A 215
ASN A 247
VAL A 252
 None
 1.02A 5ajqA-1dedA:
0.0		 5ajqA-1dedA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecw GAG POLYPROTEIN

(Simian
immunodeficiency
virus) 		PF00540
(Gag_p17) 		4 VAL A  82
ILE A  88
ASN A  53
VAL A   7
 None
 1.23A 5ajqA-1ecwA:
undetectable		 5ajqA-1ecwA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fsu N-ACETYLGALACTOSAMIN
E-4-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase) 		4 VAL A 241
ILE A  67
ASN A 311
VAL A 329
 None
 1.32A 5ajqA-1fsuA:
0.0		 5ajqA-1fsuA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gu1 3-DEHYDROQUINATE
DEHYDRATASE

(Streptomyces
coelicolor) 		PF01220
(DHquinase_II) 		4 VAL A  63
ILE A  76
ASN A  95
VAL A 122
 None
 1.31A 5ajqA-1gu1A:
0.0		 5ajqA-1gu1A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 VAL A 944
ILE A 979
ASN A 976
VAL A 992
 None
 1.20A 5ajqA-1hn0A:
0.3		 5ajqA-1hn0A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hu3 EIF4GII

(Homo sapiens) 		PF02854
(MIF4G) 		4 VAL A 782
ILE A 792
ASN A 832
VAL A 817
 None
 1.27A 5ajqA-1hu3A:
undetectable		 5ajqA-1hu3A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ni3 YCHF GTP-BINDING
PROTEIN

(Schizosaccharomyces
pombe) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		4 VAL A 138
ILE A 141
ASN A 243
VAL A 123
 None
 1.25A 5ajqA-1ni3A:
0.0		 5ajqA-1ni3A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oz7 ECHICETIN B-CHAIN

(Echis carinatus) 		PF00059
(Lectin_C) 		4 VAL B 118
ILE B  66
ASN B 101
VAL B  48
 None
 1.14A 5ajqA-1oz7B:
0.0		 5ajqA-1oz7B:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)

(Rattus
norvegicus) 		PF00351
(Biopterin_H)
PF01842
(ACT) 		4 VAL A 118
ILE A  38
ASN A 426
VAL A 412
 None
 1.26A 5ajqA-1phzA:
0.5		 5ajqA-1phzA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pox PYRUVATE OXIDASE

(Lactobacillus
plantarum) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 VAL A 149
ILE A 168
ASN A 127
VAL A 165
 None
 1.35A 5ajqA-1poxA:
undetectable		 5ajqA-1poxA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		4 VAL A 211
ILE A  31
ASN A 110
VAL A  38
 None
 1.20A 5ajqA-1rj6A:
undetectable		 5ajqA-1rj6A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II

(Homo sapiens) 		PF00106
(adh_short) 		4 VAL A  87
ILE A  15
ASN A 152
VAL A 128
 None
 1.22A 5ajqA-1so8A:
undetectable		 5ajqA-1so8A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tfe ELONGATION FACTOR TS

(Thermus
thermophilus) 		PF00889
(EF_TS) 		4 VAL A 108
ILE A 173
ASN A  77
VAL A  74
 None
 1.35A 5ajqA-1tfeA:
undetectable		 5ajqA-1tfeA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujc PHOSPHOHISTIDINE
PHOSPHATASE SIXA

(Escherichia
coli) 		PF00300
(His_Phos_1) 		4 VAL A  43
ILE A 133
ASN A 147
VAL A   3
 None
 1.20A 5ajqA-1ujcA:
undetectable		 5ajqA-1ujcA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v02 DHURRINASE

(Sorghum bicolor) 		PF00232
(Glyco_hydro_1) 		4 VAL A 447
ILE A 387
ASN A 405
VAL A 436
 None
 1.23A 5ajqA-1v02A:
undetectable		 5ajqA-1v02A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfg POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol) 		4 VAL A  35
ILE A  15
ASN A 116
VAL A   2
 None
 1.33A 5ajqA-1vfgA:
undetectable		 5ajqA-1vfgA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa3 2-KETO-3-DEOXY-6-PHO
SPHOGLUCONATE
ALDOLASE

(Thermotoga
maritima) 		PF01081
(Aldolase) 		4 VAL A 172
ILE A 200
ASN A 163
VAL A 177
 None
 1.30A 5ajqA-1wa3A:
undetectable		 5ajqA-1wa3A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeg HYPOTHETICAL PROTEIN
AGR_PAT_140

(Agrobacterium
fabrum) 		PF02586
(SRAP) 		4 VAL A 120
ILE A 158
ASN A  99
VAL A 200
 None
 0.97A 5ajqA-2aegA:
undetectable		 5ajqA-2aegA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb0 IMIDAZOLONEPROPIONAS
E

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		4 VAL A 268
ILE A 365
ASN A 360
VAL A 292
 None
 1.26A 5ajqA-2bb0A:
undetectable		 5ajqA-2bb0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE

(Xanthomonas
citri) 		PF01663
(Phosphodiest) 		4 VAL A 184
ILE A  51
ASN A  68
VAL A 230
 None
 1.08A 5ajqA-2gsnA:
undetectable		 5ajqA-2gsnA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mk2 PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo sapiens) 		PF00017
(SH2) 		4 VAL A  52
ILE A  91
ASN A  98
VAL A  73
 None
 1.07A 5ajqA-2mk2A:
undetectable		 5ajqA-2mk2A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2muy ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH

(Escherichia
coli) 		PF06480
(FtsH_ext) 		4 VAL A  88
ILE A  56
ASN A  80
VAL A  46
 None
 1.31A 5ajqA-2muyA:
undetectable		 5ajqA-2muyA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 VAL A 393
ILE A 257
ASN A 235
VAL A  61
 None
None
GLC  A1001 (-3.6A)
UNX  A   4 (-4.1A)
 1.22A 5ajqA-2nztA:
undetectable		 5ajqA-2nztA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okv PROBABLE
D-TYROSYL-TRNA(TYR)
DEACYLASE 1

(Homo sapiens) 		PF02580
(Tyr_Deacylase) 		4 VAL A   5
ILE A  74
ASN A  51
VAL A  46
 MG  A1201 ( 4.9A)
None
None
None
 1.14A 5ajqA-2okvA:
undetectable		 5ajqA-2okvA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prr ALKYLHYDROPEROXIDASE
AHPD CORE:
UNCHARACTERIZED
PEROXIDASE-RELATED
PROTEIN

(Cupriavidus
pinatubonensis) 		PF02627
(CMD) 		4 VAL A  13
ILE A  27
ASN A 183
VAL A  40
 None
None
None
PEG  A 199 (-4.5A)
 1.32A 5ajqA-2prrA:
undetectable		 5ajqA-2prrA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pts ADENYLOSUCCINATE
LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		4 VAL A  12
ILE A 350
ASN A 345
VAL A 320
 None
 1.33A 5ajqA-2ptsA:
undetectable		 5ajqA-2ptsA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pts ADENYLOSUCCINATE
LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		4 VAL A 320
ILE A 350
ASN A 313
VAL A  12
 None
 1.23A 5ajqA-2ptsA:
undetectable		 5ajqA-2ptsA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1w PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE

(Bordetella
bronchiseptica) 		PF01370
(Epimerase) 		4 VAL A  95
ILE A  55
ASN A  62
VAL A 101
 None
NAD  A 501 (-3.9A)
None
None
 1.34A 5ajqA-2q1wA:
undetectable		 5ajqA-2q1wA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ral SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN G

(Staphylococcus
epidermidis) 		PF10425
(SdrG_C_C) 		4 VAL A 488
ILE A 453
ASN A 466
VAL A 526
 None
 1.16A 5ajqA-2ralA:
undetectable		 5ajqA-2ralA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd9 ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL

(Homo sapiens) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 VAL A 111
ILE A 138
ASN A 268
VAL A 116
 None
 1.28A 5ajqA-2wd9A:
undetectable		 5ajqA-2wd9A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b20 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(NADP+)

(Synechococcus
elongatus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 VAL A 310
ILE A 173
ASN A 170
VAL A 163
 None
 1.33A 5ajqA-3b20A:
undetectable		 5ajqA-3b20A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmy PROTEIN FDRA

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 VAL A 151
ILE A 123
ASN A 135
VAL A 170
 None
 1.27A 5ajqA-3dmyA:
undetectable		 5ajqA-3dmyA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e57 UNCHARACTERIZED
PROTEIN TM1382

(Thermotoga
maritima) 		PF00293
(NUDIX) 		4 VAL A   9
ILE A  58
ASN A 133
VAL A 142
 None
 1.31A 5ajqA-3e57A:
undetectable		 5ajqA-3e57A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1

(Saccharomyces
cerevisiae) 		PF00085
(Thioredoxin) 		4 VAL A 179
ILE A 163
ASN A 209
VAL A 235
 None
 1.26A 5ajqA-3ed3A:
undetectable		 5ajqA-3ed3A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbt CHORISMATE MUTASE
AND SHIKIMATE
5-DEHYDROGENASE
FUSION PROTEIN

(Clostridium
acetobutylicum) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 VAL A 274
ILE A 242
ASN A 237
VAL A 230
 None
 1.25A 5ajqA-3fbtA:
undetectable		 5ajqA-3fbtA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3feo MBT
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02820
(MBT) 		4 VAL A  28
ILE A  43
ASN A  94
VAL A 148
 None
 1.33A 5ajqA-3feoA:
undetectable		 5ajqA-3feoA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE

(Pimelobacter
simplex) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		4 VAL A 298
ILE A 313
ASN A  27
VAL A  18
 None
 1.35A 5ajqA-3k30A:
undetectable		 5ajqA-3k30A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcu PROBABLE FORMATE
TRANSPORTER 1

(Escherichia
coli) 		PF01226
(Form_Nir_trans) 		4 VAL A 149
ILE A 221
ASN A 213
VAL A 157
 None
 1.07A 5ajqA-3kcuA:
undetectable		 5ajqA-3kcuA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Ehrlichia
chaffeensis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 VAL A  82
ILE A  98
ASN A  57
VAL A  63
 None
 0.89A 5ajqA-3l0gA:
undetectable		 5ajqA-3l0gA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqt MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A  29
ILE A 102
ASN A  65
VAL A  70
 None
 1.08A 5ajqA-3mqtA:
undetectable		 5ajqA-3mqtA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mws HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 VAL A  13
ILE A  33
ASN A  88
VAL A  62
 None
 1.25A 5ajqA-3mwsA:
undetectable		 5ajqA-3mwsA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nku DRRA

(Legionella
pneumophila) 		no annotation 4 VAL A  94
ILE A 160
ASN A 134
VAL A 129
 None
 1.32A 5ajqA-3nkuA:
undetectable		 5ajqA-3nkuA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5n RIBOFLAVIN UPTAKE
PROTEIN

(Staphylococcus
aureus) 		PF12822
(ECF_trnsprt) 		4 VAL A 134
ILE A 129
ASN A 164
VAL A 157
 None
None
RBF  A 190 (-3.3A)
None
 1.03A 5ajqA-3p5nA:
undetectable		 5ajqA-3p5nA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9h TUMOR SUSCEPTIBILITY
GENE 101 PROTEIN

(Homo sapiens) 		PF05743
(UEV) 		4 VAL A 141
ILE A  72
ASN A  69
VAL A  61
 None
 1.07A 5ajqA-3p9hA:
undetectable		 5ajqA-3p9hA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfh EPIDERMIN LEADER
PEPTIDE PROCESSING
SERINE PROTEASE EPIP

(Staphylococcus
aureus) 		PF00082
(Peptidase_S8) 		4 VAL A 323
ILE A 230
ASN A 242
VAL A 245
 None
 1.30A 5ajqA-3qfhA:
undetectable		 5ajqA-3qfhA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6k VP1 PROTEIN

(Norwalk virus) 		PF08435
(Calici_coat_C) 		4 VAL A 376
ILE A 368
ASN A 291
VAL A 294
 None
 1.31A 5ajqA-3r6kA:
undetectable		 5ajqA-3r6kA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A

(Fervidobacterium
nodosum) 		PF00150
(Cellulase) 		4 VAL A 223
ILE A 164
ASN A 178
VAL A 216
 None
 1.08A 5ajqA-3rjyA:
undetectable		 5ajqA-3rjyA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Neisseria
meningitidis) 		PF00793
(DAHP_synth_1) 		4 VAL A  17
ILE A   3
ASN A   6
VAL A 107
 None
 1.12A 5ajqA-3stgA:
undetectable		 5ajqA-3stgA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 VAL A 217
ILE A 134
ASN A 171
VAL A 188
 None
 1.34A 5ajqA-3u1kA:
undetectable		 5ajqA-3u1kA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus) 		PF00708
(Acylphosphatase)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 VAL A  29
ILE A  16
ASN A  44
VAL A  23
 None
None
PO4  A 803 (-3.4A)
PO4  A 803 (-4.1A)
 1.07A 5ajqA-3vthA:
undetectable		 5ajqA-3vthA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wso F-BOX ONLY PROTEIN
44

(Homo sapiens) 		PF04300
(FBA)
PF12937
(F-box-like) 		4 VAL A 178
ILE A 158
ASN A  80
VAL A 139
 None
 1.31A 5ajqA-3wsoA:
0.5		 5ajqA-3wsoA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wt2 PROTEIN
DISULFIDE-ISOMERASE

(Humicola
insolens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		4 VAL A 392
ILE A 358
ASN A 344
VAL A 339
 None
 1.34A 5ajqA-3wt2A:
undetectable		 5ajqA-3wt2A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpx LIPASE

(Ustilago maydis) 		PF03583
(LIP) 		4 VAL A 263
ILE A 290
ASN A 226
VAL A 238
 None
 1.35A 5ajqA-3zpxA:
0.0		 5ajqA-3zpxA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b60 FIBRONECTIN-BINDING
PROTEIN A

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		4 VAL A 217
ILE A 320
ASN A 252
VAL A 312
 None
 1.21A 5ajqA-4b60A:
undetectable		 5ajqA-4b60A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  79
ILE A  29
ASN A   6
VAL A  10
 None
 1.15A 5ajqA-4bbmA:
23.9		 5ajqA-4bbmA:
28.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhy ALANINE RACEMASE

(Aeromonas
hydrophila) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 VAL A 307
ILE A 293
ASN A 290
VAL A 322
 None
 1.18A 5ajqA-4bhyA:
undetectable		 5ajqA-4bhyA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cg4 PYRIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		4 VAL A 691
ILE A 720
ASN A 733
VAL A 659
 None
 1.29A 5ajqA-4cg4A:
undetectable		 5ajqA-4cg4A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7a TRNA
THREONYLCARBAMOYLADE
NOSINE DEHYDRATASE

(Escherichia
coli) 		PF00899
(ThiF) 		4 VAL A 125
ILE A 139
ASN A 145
VAL A 114
 None
 1.34A 5ajqA-4d7aA:
undetectable		 5ajqA-4d7aA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE

(Paraburkholderia
xenovorans) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 VAL A 210
ILE A 161
ASN A 128
VAL A 336
 None
None
None
UNL  A 401 ( 4.9A)
 1.26A 5ajqA-4efiA:
undetectable		 5ajqA-4efiA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ell RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A) 		4 VAL A 493
ILE A 536
ASN A 541
VAL A 456
 None
 1.35A 5ajqA-4ellA:
undetectable		 5ajqA-4ellA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 VAL A 841
ILE A 705
ASN A 683
VAL A 509
 None
None
BGC  A1003 (-3.9A)
None
 1.24A 5ajqA-4f9oA:
undetectable		 5ajqA-4f9oA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3t OXIDOREDUCTASE DPRE1

(Mycolicibacterium
smegmatis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		4 VAL A 414
ILE A 358
ASN A 392
VAL A 395
 None
 1.31A 5ajqA-4g3tA:
undetectable		 5ajqA-4g3tA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP

(Aspergillus
fumigatus) 		PF07504
(FTP) 		4 VAL B 126
ILE B  78
ASN B 117
VAL B  46
 None
 1.14A 5ajqA-4k90B:
undetectable		 5ajqA-4k90B:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kk1 TUBEROUS SCLEROSIS 1
PROTEIN HOMOLOG

(Schizosaccharomyces
pombe) 		PF04388
(Hamartin) 		4 VAL A  75
ILE A  57
ASN A  12
VAL A   7
 None
 1.18A 5ajqA-4kk1A:
undetectable		 5ajqA-4kk1A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK

(Escherichia
coli) 		PF02733
(Dak1) 		4 VAL A 215
ILE A 187
ASN A 283
VAL A 150
 None
 1.22A 5ajqA-4lryA:
undetectable		 5ajqA-4lryA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM1
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM2

(Saccharomyces
cerevisiae) 		PF01423
(LSM) 		4 VAL B  17
ILE B  60
ASN B  37
VAL A 110
 None
 1.21A 5ajqA-4m75B:
undetectable		 5ajqA-4m75B:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2

(Caldanaerobacter
subterraneus) 		no annotation 4 VAL B  76
ILE B  64
ASN B  67
VAL B  85
 None
 1.02A 5ajqA-4mkiB:
undetectable		 5ajqA-4mkiB:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnp N-ACETYLNEURAMINATE-
BINDING PROTEIN

(Fusobacterium
nucleatum) 		PF03480
(DctP) 		4 VAL A  99
ILE A  89
ASN A  93
VAL A 305
 None
 1.31A 5ajqA-4mnpA:
undetectable		 5ajqA-4mnpA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4na3 POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 VAL A 502
ILE A 585
ASN A 460
VAL A 463
 None
 1.25A 5ajqA-4na3A:
undetectable		 5ajqA-4na3A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6x PHOSPHOLIPASE D
STSICTOX-BETAIC1

(Sicarius
terrosus) 		no annotation 4 VAL A 242
ILE A 228
ASN A   8
VAL A 256
 None
 1.34A 5ajqA-4q6xA:
undetectable		 5ajqA-4q6xA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiq D-XYLOSE-PROTON
SYMPORTER

(Escherichia
coli) 		PF00083
(Sugar_tr) 		4 VAL A 140
ILE A  69
ASN A 419
VAL A 412
 None
 1.28A 5ajqA-4qiqA:
undetectable		 5ajqA-4qiqA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roa SERPIN 2

(Anopheles
gambiae) 		PF00079
(Serpin) 		4 VAL A 132
ILE A 189
ASN A 123
VAL A 151
 None
 1.20A 5ajqA-4roaA:
undetectable		 5ajqA-4roaA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT

(Pseudomonas
mendocina) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 VAL A 203
ILE A 320
ASN A 313
VAL A 305
 None
 1.17A 5ajqA-4wqmA:
undetectable		 5ajqA-4wqmA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x04 SOLUTE BINDING
PROTEIN

(Citrobacter
koseri) 		PF03480
(DctP) 		4 VAL A 291
ILE A 156
ASN A 222
VAL A 226
 None
 1.28A 5ajqA-4x04A:
undetectable		 5ajqA-4x04A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x54 OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Brucella ovis) 		PF13561
(adh_short_C2) 		4 VAL A  77
ILE A  89
ASN A 108
VAL A  30
 None
 1.09A 5ajqA-4x54A:
undetectable		 5ajqA-4x54A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 VAL A 696
ILE A 693
ASN A 674
VAL A 658
 None
 1.17A 5ajqA-4xhjA:
undetectable		 5ajqA-4xhjA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj5 PYRUVATE KINASE PKM

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		4 VAL A 511
ILE A 451
ASN A 491
VAL A 530
 None
 1.17A 5ajqA-4yj5A:
undetectable		 5ajqA-4yj5A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm4 AMINOTRANSFERASE

(Streptomyces
pactum) 		PF00202
(Aminotran_3) 		4 VAL A  41
ILE A  57
ASN A  61
VAL A  35
 None
 1.32A 5ajqA-4zm4A:
undetectable		 5ajqA-4zm4A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7t TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE

(Sulfolobus
acidocaldarius) 		no annotation 4 VAL A  91
ILE A 229
ASN A 175
VAL A 156
 None
 1.28A 5ajqA-5a7tA:
undetectable		 5ajqA-5a7tA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ap9 LIPASE

(Thermomyces
lanuginosus) 		PF01764
(Lipase_3)
PF03893
(Lipase3_N) 		4 VAL A   2
ILE A 196
ASN A  11
VAL A 230
 None
 1.31A 5ajqA-5ap9A:
undetectable		 5ajqA-5ap9A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0s HEMAGGLUTININ,
ENVELOPE
GLYCOPROTEIN,
FIBRITIN FUSION
PROTEIN

(Escherichia
virus T4;
Human
immunodeficiency
virus 1;
Influenza A
virus) 		PF00509
(Hemagglutinin)
PF07921
(Fibritin_C) 		4 VAL A 103
ILE A  96
ASN A 186
VAL A  30
 None
 1.24A 5ajqA-5c0sA:
undetectable		 5ajqA-5c0sA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdh MAJOR ACID
PHOSPHATASE

(Legionella
pneumophila) 		PF00328
(His_Phos_2) 		4 VAL A 287
ILE A 321
ASN A 304
VAL A  29
 None
None
1PE  A 405 (-3.6A)
None
 1.33A 5ajqA-5cdhA:
undetectable		 5ajqA-5cdhA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 VAL A 211
ILE A  31
ASN A 110
VAL A  38
 None
 1.30A 5ajqA-5cjfA:
undetectable		 5ajqA-5cjfA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjs DESIGNED INFLUENZA
HEMAGGLUTININ STEM
#4454, HA1
DESIGNED INFLUENZA
HEMAGGLUTININ STEM
#4454, HA2

(synthetic
construct) 		PF00509
(Hemagglutinin) 		4 VAL D  55
ILE D  48
ASN D 104
VAL C  40
 None
 1.17A 5ajqA-5cjsD:
undetectable		 5ajqA-5cjsD:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3v ADENYLOSUCCINATE
LYASE

(Salmonella
enterica) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		4 VAL A  12
ILE A 350
ASN A 345
VAL A 320
 None
 1.30A 5ajqA-5e3vA:
undetectable		 5ajqA-5e3vA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5euh PUTATIVE GGDEF
DOMAIN MEMBRANE
PROTEIN

(Pseudomonas
fluorescens) 		PF00990
(GGDEF) 		4 VAL A 498
ILE A 376
ASN A 407
VAL A 446
 None
 1.07A 5ajqA-5euhA:
undetectable		 5ajqA-5euhA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP2

(Rhinovirus C) 		PF00073
(Rhv) 		4 VAL A 233
ILE C 127
ASN C 222
VAL C 206
 None
 1.21A 5ajqA-5k0uA:
undetectable		 5ajqA-5k0uA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9o HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 VAL F 384
ILE F 377
ASN F 433
VAL F  40
 None
 1.16A 5ajqA-5k9oF:
undetectable		 5ajqA-5k9oF:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kp9 EPN-01*

(Human
immunodeficiency
virus 1;
Thermotoga
maritima) 		PF01081
(Aldolase) 		4 VAL B 170
ILE B 198
ASN B 161
VAL B 175
 None
 1.26A 5ajqA-5kp9B:
undetectable		 5ajqA-5kp9B:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2q SERINE/THREONINE-PRO
TEIN KINASE 40

(Homo sapiens) 		no annotation 4 VAL C 263
ILE C 177
ASN C 158
VAL C 163
 None
 1.21A 5ajqA-5l2qC:
21.4		 5ajqA-5l2qC:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncl CBK1 KINASE
ACTIVATOR PROTEIN
MOB2

(Saccharomyces
cerevisiae) 		no annotation 4 VAL B 148
ILE B 229
ASN B 138
VAL B 143
 None
 1.11A 5ajqA-5nclB:
undetectable		 5ajqA-5nclB:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny0 L. REUTERIS SRRP
BINDING REGION

(Lactobacillus
reuteri) 		no annotation 4 VAL A 609
ILE A 555
ASN A 544
VAL A 620
 None
 1.09A 5ajqA-5ny0A:
undetectable		 5ajqA-5ny0A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oom 39S RIBOSOMAL
PROTEIN L43,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 VAL b  47
ILE b  63
ASN b  66
VAL b  75
 None
 1.32A 5ajqA-5oomb:
undetectable		 5ajqA-5oomb:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujz HEMAGGLUTININ HA1
HEMAGGLUTININ HA2

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 VAL B 555
ILE B 548
ASN B 604
VAL A  34
 None
 0.93A 5ajqA-5ujzB:
undetectable		 5ajqA-5ujzB:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6

(Homo sapiens) 		PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		4 VAL A  86
ILE A 166
ASN A 152
VAL A 146
 None
 1.34A 5ajqA-5y3rA:
undetectable		 5ajqA-5y3rA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2e DIHYDRODIPICOLINATE
REDUCTASE

(Paenisporosarcina
sp. TG-14) 		no annotation 4 VAL A  71
ILE A   6
ASN A  24
VAL A 243
 None
 1.09A 5ajqA-5z2eA:
undetectable		 5ajqA-5z2eA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zfh KALLIKREIN-7

(Mus musculus) 		no annotation 4 VAL A 171
ILE A 163
ASN A 189
VAL A 227
 None
 1.21A 5ajqA-5zfhA:
undetectable		 5ajqA-5zfhA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d8w HEMAGGLUTININ

(Influenza A
virus) 		no annotation 4 VAL A 384
ILE A 377
ASN A 433
VAL A  32
 None
 1.31A 5ajqA-6d8wA:
undetectable		 5ajqA-6d8wA:
17.00