SIMILAR PATTERNS OF AMINO ACIDS FOR 5ACL_A_SASA1111

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4j ANTIBODY

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  32
SER L  34
TYR L  36
PHE L  96
 None
 0.96A 5aclA-1b4jL:
17.4		 5aclA-1b4jL:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4j ANTIBODY

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  32
SER L  34
TYR L  36
TYR L  49
 None
 0.78A 5aclA-1b4jL:
17.4		 5aclA-1b4jL:
26.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kcv PC282 IMMUNOGLOBULIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  32
SER L  34
TYR L  36
TYR L  49
 None
 0.42A 5aclA-1kcvL:
18.4		 5aclA-1kcvL:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mcw IMMUNOGLOBULIN WEIR
(LIGHT CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER W  36
TYR W  51
PRO W  57
PHE W  99
 None
 1.13A 5aclA-1mcwW:
17.1		 5aclA-1mcwW:
66.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mkm ICLR TRANSCRIPTIONAL
REGULATOR

(Thermotoga
maritima) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		4 SER A 230
TYR A 183
TYR A 229
GLU A 228
 None
 1.06A 5aclA-1mkmA:
undetectable		 5aclA-1mkmA:
18.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION

(Homo sapiens) 		PF07686
(V-set) 		5 TYR A  32
TYR A  36
TYR A  49
GLU A  50
PRO A  55
 None
 0.76A 5aclA-1pw3A:
19.5		 5aclA-1pw3A:
60.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzx HYPOTHETICAL PROTEIN
APC36103

(Geobacillus
stearothermophilus) 		PF02645
(DegV) 		4 TYR A  75
TYR A 143
GLU A   4
PHE A 112
 None
 0.90A 5aclA-1pzxA:
undetectable		 5aclA-1pzxA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te1 ENDO-1,4-XYLANASE

(Talaromyces
funiculosus) 		PF00457
(Glyco_hydro_11) 		4 TYR B  72
TYR B  35
GLU B 176
PHE B  65
 None
None
None
EDO  B 208 (-4.7A)
 1.09A 5aclA-1te1B:
undetectable		 5aclA-1te1B:
21.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uyw FAB ANTIBODY HEAVY
CHAIN
FAB ANTIBODY LIGHT
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  32
SER L  34
TYR L  36
TYR H 100
 None
 0.85A 5aclA-1uywL:
18.2		 5aclA-1uywL:
31.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uyw FAB ANTIBODY LIGHT
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  32
SER L  34
TYR L  36
TYR L  49
 None
 0.54A 5aclA-1uywL:
18.2		 5aclA-1uywL:
31.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zs3 LACTOCOCCUS LACTIS
MG1363 DPSA

(Lactococcus
lactis) 		no annotation 4 SER A  36
TYR A  96
GLU A  92
PHE A  72
 None
 1.16A 5aclA-1zs3A:
undetectable		 5aclA-1zs3A:
16.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a9m FLUORESCEIN-SCFV
HEAVY CHAIN
FLUORESCEIN-SCFV
LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 TYR H 133
TYR L  44
TYR L  57
PRO L  71
 None
 0.82A 5aclA-2a9mH:
14.3		 5aclA-2a9mH:
31.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a9m FLUORESCEIN-SCFV
LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 TYR L  40
TYR L  44
TYR L  57
PRO L  71
 None
 0.87A 5aclA-2a9mL:
21.2		 5aclA-2a9mL:
70.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dn4 GENERAL
TRANSCRIPTION FACTOR
II-I

(Homo sapiens) 		PF02946
(GTF2I) 		4 TYR A  45
GLU A  47
PRO A  50
PHE A  37
 None
 1.17A 5aclA-2dn4A:
undetectable		 5aclA-2dn4A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7z ACETYLENE HYDRATASE
AHY

(Pelobacter
acetylenicus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 TYR A 383
SER A 375
GLU A 372
PRO A 558
 None
 1.07A 5aclA-2e7zA:
undetectable		 5aclA-2e7zA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE

(Brassica juncea) 		PF04107
(GCS2) 		4 TYR A 383
GLU A 385
PRO A 376
PHE A 251
 None
 1.02A 5aclA-2gwcA:
undetectable		 5aclA-2gwcA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 TYR A 645
TYR A 835
GLU A 838
PHE A 627
 None
 1.09A 5aclA-2hpiA:
undetectable		 5aclA-2hpiA:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idy NSP3

(Severe acute
respiratory
syndrome-related
coronavirus) 		no annotation 4 TYR A  19
GLU A  46
PRO A   2
PHE A  99
 None
 1.18A 5aclA-2idyA:
undetectable		 5aclA-2idyA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iiz MELANIN BIOSYNTHESIS
PROTEIN TYRA,
PUTATIVE

(Shewanella
oneidensis) 		PF04261
(Dyp_perox) 		4 TYR A 247
TYR A 111
GLU A 135
PHE A 138
 None
 1.11A 5aclA-2iizA:
undetectable		 5aclA-2iizA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mev MENGO VIRUS COAT
PROTEIN (SUBUNIT
VP3)

(Cardiovirus A) 		PF00073
(Rhv) 		4 TYR 3  64
GLU 3  66
PRO 3  63
PHE 3 114
 None
 1.13A 5aclA-2mev3:
undetectable		 5aclA-2mev3:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mma MONOTHIOL
GLUTAREDOXIN-S14,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00462
(Glutaredoxin) 		4 SER A 133
TYR A 142
GLU A 131
PHE A 138
 None
 1.14A 5aclA-2mmaA:
undetectable		 5aclA-2mmaA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF04072
(LCM) 		4 SER A 230
TYR A 271
TYR A 231
GLU A 201
 None
 1.10A 5aclA-2ob1A:
undetectable		 5aclA-2ob1A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vul GH11 XYLANASE

(Escherichia
coli) 		PF00457
(Glyco_hydro_11) 		4 TYR A  76
TYR A  39
GLU A 181
PHE A  69
 None
 1.11A 5aclA-2vulA:
undetectable		 5aclA-2vulA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w47 LIPOLYTIC ENZYME,
G-D-S-L

(Ruminiclostridium
thermocellum) 		PF16990
(CBM_35) 		4 TYR A  34
TYR A  41
GLU A  43
PHE A  58
 None
 1.05A 5aclA-2w47A:
2.4		 5aclA-2w47A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ws9 P1

(Equine rhinitis
A virus) 		PF00073
(Rhv) 		4 TYR 3  61
GLU 3  63
PRO 3  60
PHE 3 110
 None
 1.14A 5aclA-2ws93:
undetectable		 5aclA-2ws93:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ws9 P1

(Equine rhinitis
A virus) 		PF00073
(Rhv) 		4 TYR 3  61
GLU 3  63
PRO 3  60
PHE 3 120
 None
 1.17A 5aclA-2ws93:
undetectable		 5aclA-2ws93:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 TYR A 523
SER A 526
GLU A 411
PHE A 457
 3ES  A1635 (-3.4A)
None
ZN  A1628 ( 2.4A)
3ES  A1635 (-4.1A)
 0.97A 5aclA-2xy9A:
undetectable		 5aclA-2xy9A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 TYR A 501
SER A 504
GLU A 389
PHE A 435
 3ES  A1611 (-3.5A)
None
ZN  A1620 ( 2.4A)
3ES  A1611 ( 4.2A)
 1.07A 5aclA-2xydA:
undetectable		 5aclA-2xydA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x POLYPHENOL OXIDASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 TYR A  97
TYR A  82
PRO A 341
PHE A 288
 None
 1.18A 5aclA-2y9xA:
undetectable		 5aclA-2y9xA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn9 PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 SER A 126
TYR A 125
PRO A 381
PHE A 128
 None
 1.10A 5aclA-3fn9A:
5.8		 5aclA-3fn9A:
8.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3go1 FAB 268-D, LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  32
TYR L  36
TYR L  49
PRO L  55
 None
 0.53A 5aclA-3go1L:
20.4		 5aclA-3go1L:
56.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN

(Namalycastis
sp. ST01) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 SER A  93
TYR A  97
TYR A  92
GLU A  91
 None
 1.14A 5aclA-3l2eA:
undetectable		 5aclA-3l2eA:
14.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mj8 STIMULATORY HAMSTER
ANTIBODY HL4E10 FAB
LIGHT CHAIN

(Cricetulus
migratorius) 		no annotation 5 TYR L  32
TYR L  36
TYR L  49
GLU L  50
PRO L  55
 None
 0.87A 5aclA-3mj8L:
20.0		 5aclA-3mj8L:
60.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mlu HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 2557 FAB
LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 TYR L  32
SER L  34
TYR L  36
TYR L  49
PRO L  55
 None
 0.68A 5aclA-3mluL:
19.4		 5aclA-3mluL:
50.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nps S4 FAB LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 TYR C  32
SER C  34
TYR C  36
TYR C  49
PRO C  55
 None
 0.70A 5aclA-3npsC:
21.5		 5aclA-3npsC:
65.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p30 1281 FAB LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  32
TYR L  36
TYR L  49
PRO L  55
 None
 0.51A 5aclA-3p30L:
20.9		 5aclA-3p30L:
66.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3roh LEUCOTOXIN LUKEV

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		4 TYR A 279
TYR A 269
GLU A 281
PHE A 273
 None
 1.13A 5aclA-3rohA:
undetectable		 5aclA-3rohA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwa FLUORESCENT PROTEIN
FP480

(Entacmaea
quadricolor) 		PF01353
(GFP) 		4 TYR A  26
TYR A 218
GLU A 225
PHE A 149
 None
 1.18A 5aclA-3rwaA:
undetectable		 5aclA-3rwaA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sks PUTATIVE
OLIGOENDOPEPTIDASE F

(Bacillus
anthracis) 		no annotation 4 TYR A 331
TYR A 365
GLU A 366
PHE A 370
 None
 1.16A 5aclA-3sksA:
undetectable		 5aclA-3sksA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5r UNCHARACTERIZED
PROTEIN

(Sinorhizobium
meliloti) 		PF00578
(AhpC-TSA) 		4 TYR E 127
TYR E 121
GLU E 117
PHE E 125
 None
 1.05A 5aclA-3u5rE:
undetectable		 5aclA-3u5rE:
21.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ux9 SCFV ANTIBODY

(Homo sapiens) 		PF07686
(V-set) 		5 TYR B  35
SER B  37
TYR B  39
TYR B  52
PRO B  58
 None
 0.78A 5aclA-3ux9B:
21.1		 5aclA-3ux9B:
31.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 TYR A 324
SER A 322
TYR A 325
GLU A 328
 None
 1.18A 5aclA-3vueA:
undetectable		 5aclA-3vueA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvd AMINO ACID ABC
TRANSPORTER, BINDING
PROTEIN

(Thermus
thermophilus) 		PF00497
(SBP_bac_3) 		4 SER A 225
TYR A 221
GLU A 231
PHE A  25
 None
 1.12A 5aclA-3vvdA:
undetectable		 5aclA-3vvdA:
18.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wlw ANTIBODY L CHAIN

(Homo sapiens) 		no annotation 5 TYR L  34
SER L  36
TYR L  38
TYR L  51
PRO L  57
 None
 0.70A 5aclA-3wlwL:
20.8		 5aclA-3wlwL:
82.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wu1 PROTEIN C-ETS-1

(Homo sapiens) 		PF00178
(Ets) 		4 SER B 390
TYR B 412
GLU B 387
PRO B 368
 None
 1.01A 5aclA-3wu1B:
undetectable		 5aclA-3wu1B:
23.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zl4 A17 ANTIBODY FAB
FRAGMENT LAMBDA
LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  33
SER L  35
TYR L  37
PRO L  56
 None
MES  L1217 ( 3.9A)
None
None
 1.07A 5aclA-3zl4L:
21.1		 5aclA-3zl4L:
66.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zl4 A17 ANTIBODY FAB
FRAGMENT LAMBDA
LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  33
TYR L  37
TYR L  50
PRO L  56
 None
 0.76A 5aclA-3zl4L:
21.1		 5aclA-3zl4L:
66.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zse ENDO-1,4-BETA-XYLANA
SE

(Thermobifida
fusca) 		PF00457
(Glyco_hydro_11) 		4 TYR A 114
TYR A  77
GLU A 216
PHE A 107
 EDO  A1232 (-4.4A)
None
EDO  A1232 (-3.7A)
None
 1.10A 5aclA-3zseA:
undetectable		 5aclA-3zseA:
22.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aiz V2-17 PROTEIN

(Homo sapiens) 		PF07686
(V-set) 		4 TYR A  31
TYR A  35
TYR A  48
PRO A  54
 None
 0.66A 5aclA-4aizA:
20.4		 5aclA-4aizA:
54.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqa PROTEIN C-ETS-2

(Homo sapiens) 		PF00178
(Ets) 		4 SER A 418
TYR A 440
GLU A 415
PRO A 396
 None
 1.05A 5aclA-4bqaA:
undetectable		 5aclA-4bqaA:
18.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4buh CLONE M0418 SCFV

(Homo sapiens) 		PF07686
(V-set) 		4 TYR A 110
TYR A 178
TYR A 191
PRO A 197
 None
None
EDO  A1254 ( 4.0A)
EDO  A1254 ( 4.5A)
 0.95A 5aclA-4buhA:
21.8		 5aclA-4buhA:
40.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqp ANTI-METH SCFV

(Mus musculus) 		PF07686
(V-set) 		4 TYR H  94
SER H  35
TYR H  47
TYR H  33
 None
B40  H1201 (-3.4A)
B40  H1201 (-4.6A)
B40  H1201 (-3.7A)
 0.96A 5aclA-4gqpH:
17.5		 5aclA-4gqpH:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyq PHOSPHOLIPASE A1

(Streptomyces
albidoflavus) 		PF13472
(Lipase_GDSL_2) 		4 SER A  13
TYR A  35
TYR A  12
PRO A 219
 None
None
1PE  A 301 (-4.8A)
None
 0.76A 5aclA-4hyqA:
undetectable		 5aclA-4hyqA:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4laq SINGLE HEAVY CHAIN
VARIABLE FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		4 TYR H  94
SER H  35
TYR H  47
TYR H  33
 None
 0.95A 5aclA-4laqH:
12.1		 5aclA-4laqH:
34.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lar SINGLE HEAVY CHAIN
VARIABLE FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		4 TYR H  94
SER H  35
TYR H  47
TYR H  33
 None
1WE  L 300 (-3.6A)
None
1WE  L 300 (-3.9A)
 0.98A 5aclA-4larH:
14.2		 5aclA-4larH:
33.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		4 TYR A 392
GLU A 165
PRO A 381
PHE A 365
 None
 1.15A 5aclA-4n2cA:
3.9		 5aclA-4n2cA:
10.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nik SINGLE-CHAIN FV
FRAGMENT ANTIBODY

(Homo sapiens) 		PF07686
(V-set) 		6 TYR B 168
SER B 170
TYR B 172
TYR B 185
GLU B 186
PRO B 191
 None
 0.60A 5aclA-4nikB:
14.0		 5aclA-4nikB:
37.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qf1 INFERRED UNMUTATED
ANCESTOR (UA) OF
ANTI-HIV ANTIBODY
CH59

(Homo sapiens) 		no annotation 5 TYR L  32
TYR L  36
TYR L  49
GLU L  50
PRO L  55
 None
 0.81A 5aclA-4qf1L:
20.4		 5aclA-4qf1L:
57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rav SINGLE-CHAIN FV, VH
SINGLE-CHAIN FV, VL

(Homo sapiens) 		PF07686
(V-set) 		4 TYR B 161
SER B 163
TYR B 165
TYR A 101
 None
 0.85A 5aclA-4ravB:
22.1		 5aclA-4ravB:
75.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rav SINGLE-CHAIN FV, VL

(Homo sapiens) 		PF07686
(V-set) 		5 TYR B 161
SER B 163
TYR B 165
TYR B 178
PRO B 184
 None
 0.48A 5aclA-4ravB:
22.1		 5aclA-4ravB:
75.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trb PURINE
PHOSPHORIBOSYLTRANSF
ERASE (GPT-1)

(Sulfolobus
solfataricus) 		PF00156
(Pribosyltran) 		4 TYR A 127
GLU A 142
PRO A 136
PHE A 149
 None
 1.18A 5aclA-4trbA:
undetectable		 5aclA-4trbA:
18.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4unu IG LAMBDA CHAIN V-II
REGION MGC

(Homo sapiens) 		PF07686
(V-set) 		7 TYR A  34
SER A  36
TYR A  38
TYR A  51
GLU A  52
PRO A  57
PHE A  99
 15P  A1111 (-3.5A)
15P  A1111 ( 4.4A)
None
15P  A1111 (-3.4A)
None
None
None
 0.41A 5aclA-4unuA:
23.7		 5aclA-4unuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ut7 BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE2
A11

(Homo sapiens) 		PF07686
(V-set) 		4 SER L  34
TYR L  36
TYR L  49
PRO L  55
 None
 0.66A 5aclA-4ut7L:
19.0		 5aclA-4ut7L:
69.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ut7 BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE2
A11

(Homo sapiens) 		PF07686
(V-set) 		4 TYR L  36
TYR L  49
GLU L  50
PRO L  55
 None
 0.20A 5aclA-4ut7L:
19.0		 5aclA-4ut7L:
69.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4y5x DIABODY 310 VH
DOMAIN
DIABODY 310 VL
DOMAIN

(Homo sapiens) 		PF07686
(V-set) 		4 TYR A 109
TYR B  37
TYR B  50
PRO B  56
 None
 0.80A 5aclA-4y5xA:
13.3		 5aclA-4y5xA:
31.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yjz SCFV H2526

(Homo sapiens) 		PF07686
(V-set) 		4 TYR L 313
TYR L  37
TYR L  50
PRO L  56
 None
 1.05A 5aclA-4yjzL:
20.9		 5aclA-4yjzL:
65.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yo0 LIGHT CHAIN OF
ANTIGEN BINDING
FRAGMENT, FAB

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR B  52
TYR B  56
TYR B  69
PRO B  75
 None
 0.53A 5aclA-4yo0B:
19.3		 5aclA-4yo0B:
55.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z0x ANTIBODY HC26AM
LIGHT CHAIN VARIABLE
DOMAIN

(Homo sapiens) 		PF07686
(V-set) 		5 TYR A  31
SER A  33
TYR A  35
TYR A  48
PRO A  54
 None
 0.67A 5aclA-4z0xA:
20.0		 5aclA-4z0xA:
57.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zs7 LLAMA FAB FRAGMENT
68F2 LIGHT CHAIN

(Lama glama) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  34
SER L  36
TYR L  38
TYR L  51
 None
 0.74A 5aclA-4zs7L:
21.5		 5aclA-4zs7L:
67.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN

(Escherichia
virus T4;
Homo sapiens;
Mus musculus) 		PF00001
(7tm_1)
PF00339
(Arrestin_N)
PF00959
(Phage_lysozyme)
PF02752
(Arrestin_C)
PF10413
(Rhodopsin_N) 		4 TYR A  30
TYR A  26
GLU A  25
PHE A   9
 None
 1.17A 5aclA-4zwjA:
undetectable		 5aclA-4zwjA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		4 TYR A 507
SER A 510
GLU A 395
PHE A 441
 MLT  A1615 (-4.0A)
None
ZN  A1616 (-2.4A)
MLT  A1615 ( 4.8A)
 1.02A 5aclA-5a2rA:
undetectable		 5aclA-5a2rA:
10.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ado FAB A.17

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  33
TYR L  37
TYR L  50
PRO L  56
 None
DEP  L1356 (-4.0A)
None
None
 0.56A 5aclA-5adoL:
21.1		 5aclA-5adoL:
35.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5awn LIGHT CHAIN OF
3BC176 FAB

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 SER L  34
TYR L  36
TYR L  49
GLU L  50
PRO L  55
 None
 0.62A 5aclA-5awnL:
23.3		 5aclA-5awnL:
68.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej3 ENDO-1,4-BETA-XYLANA
SE B

(Streptomyces
lividans) 		PF00457
(Glyco_hydro_11) 		4 TYR A  74
TYR A  37
GLU A 177
PHE A  67
 None
 1.14A 5aclA-5ej3A:
undetectable		 5aclA-5ej3A:
20.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f6h DH427 ANTIBODY LIGHT
CHAIN

(Macaca mulatta) 		no annotation 4 SER L  36
TYR L  38
TYR L  51
PRO L  57
 None
 0.70A 5aclA-5f6hL:
22.6		 5aclA-5f6hL:
76.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f89 CAP248-2B LIGHT
CHAIN

(Homo sapiens) 		no annotation 5 TYR L  32
SER L  34
TYR L  36
TYR L  49
PRO L  55
 None
 0.73A 5aclA-5f89L:
21.4		 5aclA-5f89L:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fcs DIABODY

(Homo sapiens) 		PF07686
(V-set) 		5 TYR L  33
SER L  35
TYR L  37
TYR L  50
PRO L  56
 None
 0.61A 5aclA-5fcsL:
21.5		 5aclA-5fcsL:
64.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fcu JR4 FAB LIGHT CHAIN

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  32
TYR L  36
TYR L  49
PRO L  55
 None
 0.67A 5aclA-5fcuL:
21.7		 5aclA-5fcuL:
65.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyr PHOSPHOINOSITOL-SPEC
IFIC PHOSPHOLIPASE C

(Pseudomonas sp.) 		PF16670
(PI-PLC-C1) 		4 TYR A  29
TYR A  33
GLU A  30
PHE A  37
 None
 1.02A 5aclA-5fyrA:
undetectable		 5aclA-5fyrA:
15.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grj AVELUMAB L CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 SER L  36
TYR L  38
TYR L  51
PRO L  57
 None
 0.75A 5aclA-5grjL:
21.9		 5aclA-5grjL:
83.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gs0 LIGHT CHAIN
(ANTI-TLR3)

(Mus musculus) 		PF07686
(V-set) 		5 TYR C  31
TYR C  35
TYR C  48
GLU C  49
PRO C  54
 None
 1.14A 5aclA-5gs0C:
19.5		 5aclA-5gs0C:
60.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jo5 10E8 GLV

(Homo sapiens) 		no annotation 4 SER L  34
TYR L  36
TYR L  49
PRO L  55
 None
 0.68A 5aclA-5jo5L:
20.0		 5aclA-5jo5L:
63.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jo5 10E8 GLV

(Homo sapiens) 		no annotation 4 TYR L  32
TYR L  36
TYR L  49
PRO L  55
 None
 1.18A 5aclA-5jo5L:
20.0		 5aclA-5jo5L:
63.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jz7 MEDI578 SCFV, LIGHT
CHAIN

(Homo sapiens) 		PF07686
(V-set) 		5 TYR D  32
SER D  34
TYR D  36
TYR D  49
PRO D  55
 None
 0.73A 5aclA-5jz7D:
20.5		 5aclA-5jz7D:
63.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mal LIPASE

(Streptomyces
rimosus) 		PF13472
(Lipase_GDSL_2) 		4 SER A  12
TYR A  34
TYR A  11
PRO A 217
 None
 0.78A 5aclA-5malA:
undetectable		 5aclA-5malA:
19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5odb D10 FAB FRAGMENT -
LIGHT CHAIN

(Homo sapiens) 		no annotation 4 TYR B  32
TYR B  36
TYR B  49
PRO B  55
 None
None
None
SO4  B 301 (-4.6A)
 0.55A 5aclA-5odbB:
20.4		 5aclA-5odbB:
56.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t4z ANTIBODY DH501 FAB
LIGHT CHAIN

(Macaca mulatta) 		no annotation 4 SER L  34
TYR L  36
TYR L  49
PRO L  55
 None
 0.64A 5aclA-5t4zL:
21.3		 5aclA-5t4zL:
62.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u0r DH270.UCA1 LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 SER L  36
TYR L  38
TYR L  51
GLU L  52
PRO L  57
 None
 0.35A 5aclA-5u0rL:
22.0		 5aclA-5u0rL:
80.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u0u DH270.1 SINGLE-CHAIN
VARIABLE FRAGMENT

(Homo sapiens) 		no annotation 6 TYR G 111
SER G 175
TYR G 177
TYR G 190
GLU G 191
PRO G 196
 None
 1.06A 5aclA-5u0uG:
22.4		 5aclA-5u0uG:
78.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ukn DH522UCA FAB
FRAGMENT LIGHT CHAIN

(Macaca mulatta) 		no annotation 4 SER L  34
TYR L  36
TYR L  49
PRO L  55
 None
 0.68A 5aclA-5uknL:
22.5		 5aclA-5uknL:
85.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ukn DH522UCA FAB
FRAGMENT LIGHT CHAIN

(Macaca mulatta) 		no annotation 4 TYR L  36
TYR L  49
GLU L  50
PRO L  55
 None
 0.24A 5aclA-5uknL:
22.5		 5aclA-5uknL:
85.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0x TIP41-LIKE PROTEIN

(Mus musculus) 		no annotation 4 SER A 216
TYR A 214
GLU A 218
PHE A 185
 None
 0.77A 5aclA-5w0xA:
undetectable		 5aclA-5w0xA:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w5z 3C10 FAB LIGHT CHAIN

(Rattus
norvegicus) 		no annotation 4 TYR L  32
TYR L  36
TYR L  49
PRO L  55
 None
 0.62A 5aclA-5w5zL:
18.3		 5aclA-5w5zL:
39.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xcv VL-SARAH(S37C)
CHIMERA,VL-SARAH(S37
C) CHIMERA

(Homo sapiens;
Rattus) 		no annotation 4 TYR B  32
TYR B  36
TYR B  49
PRO B  55
 None
 0.47A 5aclA-5xcvB:
19.1		 5aclA-5xcvB:
55.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcy GLUCANASE

(Phanerochaete
chrysosporium) 		PF01341
(Glyco_hydro_6) 		4 TYR A  97
SER A  95
TYR A  98
GLU A 101
 None
 1.12A 5aclA-5xcyA:
undetectable		 5aclA-5xcyA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7y ARYL HYDROCARBON
RECEPTOR REPRESSOR

(Homo sapiens) 		PF00010
(HLH)
PF00989
(PAS) 		4 SER A  76
TYR A  77
PRO A  56
PHE A 137
 None
 1.11A 5aclA-5y7yA:
undetectable		 5aclA-5y7yA:
16.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5yax SCFV1 ANTIBODY

(Homo sapiens) 		no annotation 4 TYR A1038
TYR A1042
TYR A1055
PRO A1068
 None
 0.57A 5aclA-5yaxA:
21.0		 5aclA-5yaxA:
31.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy5 -

(-) 		no annotation 4 TYR D  33
TYR D  37
TYR D  50
PRO D  56
 None
 0.65A 5aclA-5yy5D:
19.2		 5aclA-5yy5D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cbp DH270.6 SINGLE CHAIN
VARIABLE FRAGMENT

(Homo sapiens) 		no annotation 6 TYR A 111
SER A 178
TYR A 180
TYR A 193
GLU A 194
PRO A 199
 MAN  A 304 ( 4.5A)
None
None
MAN  A 305 ( 3.8A)
MAN  A 304 ( 2.7A)
MAN  A 306 ( 4.5A)
 1.10A 5aclA-6cbpA:
14.3		 5aclA-6cbpA:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ck9 35O22 SCFV LIGHT
CHAIN PORTION

(Homo sapiens) 		no annotation 4 SER E  34
TYR E  36
TYR E  49
GLU E  50
 None
 0.83A 5aclA-6ck9E:
15.8		 5aclA-6ck9E:
46.94