SIMILAR PATTERNS OF AMINO ACIDS FOR 5AAC_A_VGHA9000_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 267
VAL A 275
ALA A 288
LYS A 290
MET A 337
GLY A 340
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.74A 5aacA-1opkA:
30.9		 5aacA-1opkA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  78
VAL A  86
ALA A  99
LYS A 101
MET A 150
GLY A 153
LEU A 201
 ATP  A 535 (-3.9A)
ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 2.5A)
None
ATP  A 535 ( 4.7A)
ATP  A 535 (-4.8A)
 0.55A 5aacA-1s9iA:
21.9		 5aacA-1s9iA:
25.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 377
ALA A 389
LYS A 391
MET A 438
GLY A 441
LEU A 489
 None
 0.47A 5aacA-1snxA:
15.3		 5aacA-1snxA:
36.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
VAL A  23
ALA A  36
LEU A  84
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.85A 5aacA-1zltA:
21.2		 5aacA-1zltA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
VAL A  23
ALA A  36
LYS A  38
LEU A  84
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
 0.85A 5aacA-1zltA:
21.2		 5aacA-1zltA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  26
VAL A  34
ALA A  47
LEU A  98
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.7A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.79A 5aacA-2bujA:
23.7		 5aacA-2bujA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  26
VAL A  34
ALA A  47
LYS A  49
LEU A  98
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.7A)
STU  A1301 ( 4.8A)
None
 0.84A 5aacA-2bujA:
23.7		 5aacA-2bujA:
25.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU X  17
VAL X  25
ALA X  37
LYS X  39
MET X  85
GLY X  88
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
None
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.73A 5aacA-2dq7X:
31.3		 5aacA-2dq7X:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
VAL A 281
ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.49A 5aacA-2h8hA:
30.0		 5aacA-2h8hA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.74A 5aacA-2h8hA:
30.0		 5aacA-2h8hA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
VAL A 281
ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.61A 5aacA-2hckA:
29.0		 5aacA-2hckA:
26.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 251
VAL A 259
ALA A 271
LYS A 273
MET A 319
GLY A 322
LEU A 371
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.77A 5aacA-2hk5A:
31.7		 5aacA-2hk5A:
36.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 248
VAL A 256
ALA A 269
LYS A 271
MET A 318
GLY A 321
LEU A 370
ASP A 381
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
None
None
GIN  A 600 (-4.7A)
GIN  A 600 (-4.9A)
 1.04A 5aacA-2hz0A:
30.7		 5aacA-2hz0A:
37.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
VAL A 596
ALA A 614
GLY A 669
LEU A 785
GLY A 795
ASP A 796
 None
 0.78A 5aacA-2ogvA:
30.5		 5aacA-2ogvA:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
VAL A 596
ALA A 614
LYS A 616
GLY A 669
LEU A 785
ASP A 796
 None
 1.01A 5aacA-2ogvA:
30.5		 5aacA-2ogvA:
36.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		7 LEU A  25
VAL A  33
ALA A  46
LYS A  48
MET A 106
GLY A 109
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
ATP  A 381 ( 4.8A)
 0.64A 5aacA-2phkA:
22.6		 5aacA-2phkA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		7 LEU A  25
VAL A  33
ALA A  46
MET A 106
GLY A 109
LEU A 156
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.69A 5aacA-2phkA:
22.6		 5aacA-2phkA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 VAL A  21
ALA A  34
LYS A  36
MET A  85
LEU A 140
GLY A 150
ASP A 151
 AGS  A3001 (-4.4A)
AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
None
None
None
AGS  A3001 (-2.8A)
 0.91A 5aacA-2pmiA:
21.3		 5aacA-2pmiA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		6 VAL B  55
ALA B  67
MET B 117
GLY B 120
LEU B 171
ASP B 182
 None
 0.54A 5aacA-2qkwB:
24.2		 5aacA-2qkwB:
27.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 635
ALA A 651
LYS A 653
MET A 702
GLY A 705
LEU A 753
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
None
 0.90A 5aacA-2qobA:
34.0		 5aacA-2qobA:
33.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 689
ALA A 705
LYS A 707
MET A 756
GLY A 759
LEU A 807
ASP A 818
 None
 1.06A 5aacA-2r2pA:
34.1		 5aacA-2r2pA:
33.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 724
VAL A 732
ALA A 749
LYS A 751
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.66A 5aacA-2r4bA:
22.8		 5aacA-2r4bA:
32.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  90
ALA A 103
LYS A 105
MET A 156
GLY A 159
LEU A 205
ASP A 216
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
None
ANP  A1480 ( 4.7A)
ANP  A1480 (-3.5A)
 1.11A 5aacA-2v55A:
19.4		 5aacA-2v55A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A 226
VAL A 234
ALA A 247
LYS A 249
LEU A 301
MET A 304
GLY A 307
LEU A 354
ASP A 368
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
XK9  A1511 (-4.6A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
XK9  A1511 (-3.6A)
 0.90A 5aacA-2xk9A:
11.2		 5aacA-2xk9A:
25.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 635
ALA A 651
LYS A 653
MET A 702
GLY A 705
LEU A 753
ASP A 764
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
None
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
None
 0.81A 5aacA-2xyuA:
33.4		 5aacA-2xyuA:
35.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  38
ALA A  51
LYS A  53
MET A 110
GLY A 113
LEU A 160
 None
B49  A1294 (-3.2A)
None
None
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
 0.54A 5aacA-2y7jA:
4.0		 5aacA-2y7jA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  68
VAL A  76
ALA A  92
LEU A 141
GLY A 147
LEU A 194
ASP A 205
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 ( 4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.93A 5aacA-2z7rA:
21.5		 5aacA-2z7rA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  68
VAL A  76
ALA A  92
LYS A  94
LEU A 141
GLY A 147
LEU A 194
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 ( 4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.77A 5aacA-2z7rA:
21.5		 5aacA-2z7rA:
23.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1002
VAL A1010
ALA A1028
MET A1079
GLY A1082
GLY A1149
ASP A1150
 S91  A   1 ( 4.1A)
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
None
S91  A   1 (-3.3A)
None
None
 0.59A 5aacA-2z8cA:
30.3		 5aacA-2z8cA:
44.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 253
VAL A 261
ALA A 273
LYS A 275
MET A 322
GLY A 325
LEU A 374
ASP A 385
 None
 0.72A 5aacA-2zv7A:
32.5		 5aacA-2zv7A:
35.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 487
VAL A 495
ALA A 515
LYS A 517
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.53A 5aacA-3b2tA:
4.9		 5aacA-3b2tA:
36.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 431
VAL A 439
ALA A 455
LYS A 457
GLY A 508
LEU A 556
GLY A 566
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
None
AGS  A 999 (-4.5A)
None
 1.07A 5aacA-3fzpA:
31.5		 5aacA-3fzpA:
34.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 LEU A 680
VAL A 689
ALA A 700
LEU A 745
LEU A 804
ASP A 828
 ADP  A2101 ( 4.1A)
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
ADP  A2101 ( 4.4A)
ADP  A2101 (-4.4A)
SR  A2103 (-2.6A)
 0.43A 5aacA-3lj0A:
23.1		 5aacA-3lj0A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  39
VAL A  47
ALA A  60
LYS A  62
LEU A 110
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.1A)
None
None
 0.85A 5aacA-3lm5A:
25.0		 5aacA-3lm5A:
28.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1005
VAL A1013
ALA A1031
LYS A1033
MET A1082
GLY A1085
GLY A1152
 None
None
None
CCX  A   1 ( 3.7A)
None
None
CCX  A   1 (-3.6A)
 0.95A 5aacA-3lw0A:
29.9		 5aacA-3lw0A:
41.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A1013
ALA A1031
LYS A1033
MET A1082
GLY A1085
GLY A1152
ASP A1153
 None
None
CCX  A   1 ( 3.7A)
None
None
CCX  A   1 (-3.6A)
CCX  A   1 ( 4.3A)
 1.12A 5aacA-3lw0A:
29.9		 5aacA-3lw0A:
41.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  88
VAL A  96
ALA A 109
LYS A 111
GLY A 165
LEU A 212
ASP A 223
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
None
None
SO4  A   5 ( 4.5A)
 0.94A 5aacA-3nuuA:
23.5		 5aacA-3nuuA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  88
VAL A  96
ALA A 109
LYS A 111
LEU A 159
GLY A 165
ASP A 223
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
JOZ  A 361 (-4.0A)
None
SO4  A   5 ( 4.5A)
 0.99A 5aacA-3nuuA:
23.5		 5aacA-3nuuA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 192
VAL A 200
ALA A 213
LEU A 263
MET A 266
GLY A 269
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.7A)
None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.67A 5aacA-3nyoA:
22.6		 5aacA-3nyoA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 192
VAL A 200
ALA A 213
LYS A 215
LEU A 263
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
AMP  A 577 ( 4.7A)
None
None
AMP  A 577 (-4.8A)
 0.70A 5aacA-3nyoA:
22.6		 5aacA-3nyoA:
19.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 726
VAL A 734
ALA A 751
LYS A 753
MET A 801
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.65A 5aacA-3pp0A:
31.3		 5aacA-3pp0A:
34.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 423
VAL A 431
ALA A 443
LYS A 445
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.45A 5aacA-3sxsA:
31.3		 5aacA-3sxsA:
34.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 LEU A 295
VAL A 303
ALA A 315
MET A 366
GLY A 369
LEU A 423
GLY A 433
 None
 0.54A 5aacA-3ulzA:
22.2		 5aacA-3ulzA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 LEU A 295
VAL A 303
LYS A 317
MET A 366
GLY A 369
LEU A 423
GLY A 433
 None
 0.72A 5aacA-3ulzA:
22.2		 5aacA-3ulzA:
28.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 544
VAL A 552
ALA A 570
LYS A 572
GLY A 623
LEU A 686
GLY A 696
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
0F4  A 902 (-3.3A)
 0.72A 5aacA-3v5qA:
30.9		 5aacA-3v5qA:
39.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 544
VAL A 552
ALA A 570
MET A 620
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.32A 5aacA-3v5qA:
30.9		 5aacA-3v5qA:
39.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 139
VAL A 147
ALA A 160
LYS A 162
LEU A 210
GLY A 216
LEU A 263
 N13  A 501 (-3.7A)
N13  A 501 ( 4.7A)
N13  A 501 ( 4.1A)
N13  A 501 (-2.9A)
N13  A 501 ( 4.8A)
N13  A 501 (-3.5A)
N13  A 501 (-4.5A)
 0.71A 5aacA-3w18A:
21.8		 5aacA-3w18A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  75
VAL A  83
ALA A  96
LYS A  98
MET A 147
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.52A 5aacA-3wigA:
23.0		 5aacA-3wigA:
24.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A1951
ALA A1978
LYS A1980
LEU A2026
MET A2029
GLY A2032
LEU A2086
GLY A2101
 VGH  A3000 ( 4.4A)
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 ( 4.2A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
VGH  A3000 (-3.5A)
 0.62A 5aacA-3zbfA:
34.7		 5aacA-3zbfA:
48.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A1951
VAL A1959
ALA A1978
LEU A2026
MET A2029
GLY A2032
LEU A2086
GLY A2101
ASP A2102
 VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.2A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
VGH  A3000 (-3.5A)
None
 0.41A 5aacA-3zbfA:
34.7		 5aacA-3zbfA:
48.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 633
ALA A 649
MET A 700
GLY A 703
LEU A 751
ASP A 762
 None
 0.41A 5aacA-3zfxA:
34.4		 5aacA-3zfxA:
35.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  83
VAL A  91
ALA A 104
LYS A 106
LEU A 154
GLY A 160
LEU A 207
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-3.3A)
None
VX6  A 500 (-3.3A)
VX6  A 500 (-4.6A)
 0.65A 5aacA-4af3A:
19.9		 5aacA-4af3A:
24.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 560
VAL A 568
ALA A 586
MET A 636
GLY A 639
LEU A 699
GLY A 709
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
LTI  A1839 (-3.4A)
None
 0.65A 5aacA-4at3A:
31.1		 5aacA-4at3A:
38.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 105
ALA A 121
LYS A 123
MET A 172
GLY A 175
LEU A 223
ASP A 234
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.56A 5aacA-4aw5A:
33.8		 5aacA-4aw5A:
34.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  69
ALA A  82
LYS A  84
LEU A 137
MET A 140
LEU A 189
GLY A 199
ASP A 200
 R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
None
R4L  A1394 (-3.9A)
None
R4L  A1394 (-4.5A)
R4L  A1394 ( 4.1A)
None
 0.93A 5aacA-4b99A:
22.1		 5aacA-4b99A:
23.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 515
VAL A 523
ALA A 541
MET A 591
GLY A 594
LEU A 656
GLY A 666
ASP A 667
 None
 0.65A 5aacA-4f0iA:
24.5		 5aacA-4f0iA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 377
VAL A 385
ALA A 400
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.56A 5aacA-4f4pA:
24.3		 5aacA-4f4pA:
32.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 514
VAL A 522
ALA A 538
LEU A 593
MET A 596
GLY A 599
ASP A 663
 0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.7A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 (-4.5A)
 0.91A 5aacA-4feqA:
10.6		 5aacA-4feqA:
36.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 514
VAL A 522
ALA A 538
LYS A 540
LEU A 593
MET A 596
GLY A 599
 0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.7A)
None
0T8  A 901 ( 3.8A)
 0.67A 5aacA-4feqA:
10.6		 5aacA-4feqA:
36.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A1122
VAL A1130
ALA A1148
LEU A1196
MET A1199
GLY A1202
LEU A1256
GLY A1269
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 (-4.5A)
0UV  A1501 ( 4.2A)
 0.29A 5aacA-4fodA:
46.0		 5aacA-4fodA:
94.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1122
VAL A1130
ALA A1148
LYS A1150
GLY A1202
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 1.02A 5aacA-4fodA:
46.0		 5aacA-4fodA:
94.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 855
VAL A 863
ALA A 880
LYS A 882
GLY A 935
LEU A 983
GLY A 993
 IZA  A2001 (-3.7A)
None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
None
 0.73A 5aacA-4gl9A:
29.1		 5aacA-4gl9A:
30.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		7 LEU A 132
VAL A 140
ALA A 156
LYS A 158
GLY A 211
LEU A 259
GLY A 269
 None
 0.51A 5aacA-4hzsA:
28.2		 5aacA-4hzsA:
33.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 132
VAL A 140
ALA A 156
LYS A 158
GLY A 211
LEU A 259
GLY A 269
ASP A 270
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
None
None
 0.70A 5aacA-4id7A:
30.9		 5aacA-4id7A:
33.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		7 LEU A 258
VAL A 266
ALA A 279
LYS A 281
LEU A 416
GLY A 426
ASP A 427
 ANP  A 601 ( 4.6A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.2A)
ANP  A 601 ( 4.9A)
None
MG  A 603 ( 2.0A)
 0.89A 5aacA-4jrnA:
19.8		 5aacA-4jrnA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  18
VAL A  26
ALA A  39
LEU A  89
GLY A  95
LEU A 143
ASP A 154
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 ( 4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
EDO  A 302 (-3.7A)
 0.76A 5aacA-4jxfA:
19.1		 5aacA-4jxfA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  18
VAL A  26
ALA A  39
LYS A  41
LEU A  89
GLY A  95
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
631  A 301 ( 4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 0.65A 5aacA-4jxfA:
19.1		 5aacA-4jxfA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
VAL A 281
ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
 0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
 0.55A 5aacA-4k11A:
29.9		 5aacA-4k11A:
26.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 273
VAL A 281
ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.69A 5aacA-4lggA:
30.0		 5aacA-4lggA:
33.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLY A 984
LEU A1030
GLY A1040
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
2TT  A1202 (-3.4A)
 0.92A 5aacA-4oliA:
28.7		 5aacA-4oliA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 192
VAL A 200
ALA A 213
LEU A 263
MET A 266
LEU A 318
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 (-4.5A)
None
SGV  A 601 (-4.9A)
 0.56A 5aacA-4tnbA:
21.1		 5aacA-4tnbA:
19.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 LEU A  14
VAL A  22
ALA A  35
LYS A  37
MET A  84
GLY A  87
LEU A 136
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.63A 5aacA-4ueuA:
32.2		 5aacA-4ueuA:
40.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 193
VAL A 201
ALA A 214
LYS A 216
MET A 267
GLY A 270
LEU A 321
ASP A 332
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
None
 0.72A 5aacA-4wboA:
23.2		 5aacA-4wboA:
22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 7 LEU B 267
VAL B 275
ALA B 288
LYS B 290
MET B 337
GLY B 340
LEU B 389
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
None
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
 0.46A 5aacA-4xeyB:
24.7		 5aacA-4xeyB:
31.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 408
VAL A 416
ALA A 428
MET A 477
GLY A 480
LEU A 528
 None
 0.56A 5aacA-4xi2A:
31.4		 5aacA-4xi2A:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 LEU A 408
VAL A 416
ALA A 428
LYS A 430
MET A 477
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.80A 5aacA-4y93A:
31.7		 5aacA-4y93A:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 193
VAL A 201
ALA A 214
LYS A 216
LEU A 264
MET A 267
LEU A 319
ASP A 330
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
AN2  A 601 ( 4.8A)
None
None
AN2  A 601 (-3.0A)
 0.80A 5aacA-4yhjA:
21.3		 5aacA-4yhjA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 193
VAL A 201
LYS A 216
MET A 267
GLY A 270
LEU A 319
ASP A 330
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
AN2  A 601 ( 3.9A)
None
None
None
AN2  A 601 (-3.0A)
 0.95A 5aacA-4yhjA:
21.3		 5aacA-4yhjA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		7 LEU A  99
VAL A 107
ALA A 120
LEU A 170
GLY A 176
LEU A 223
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-3.8A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
 0.84A 5aacA-5eykA:
24.6		 5aacA-5eykA:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		7 LEU A  99
VAL A 107
ALA A 120
LYS A 122
LEU A 170
GLY A 176
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-3.8A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
 0.75A 5aacA-5eykA:
24.6		 5aacA-5eykA:
27.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLY A 984
LEU A1030
GLY A1040
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.77A 5aacA-5f1zA:
28.0		 5aacA-5f1zA:
31.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A1092
ALA A1108
LYS A1110
LEU A1157
MET A1160
GLY A1163
ASP A1222
 63K  A1401 (-4.9A)
63K  A1401 (-3.5A)
None
63K  A1401 (-4.2A)
None
63K  A1401 (-3.6A)
None
 0.71A 5aacA-5horA:
28.3		 5aacA-5horA:
33.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 718
VAL A 726
ALA A 743
LYS A 745
MET A 793
GLY A 796
ASP A 855
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 (-4.3A)
 0.80A 5aacA-5j9zA:
32.4		 5aacA-5j9zA:
32.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 718
VAL A 726
ALA A 743
LYS A 745
MET A 793
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.54A 5aacA-5j9zA:
32.4		 5aacA-5j9zA:
32.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 VAL A 897
ALA A 909
MET A 959
GLY A 962
LEU A1016
ASP A1027
 ADP  A1200 (-4.4A)
ADP  A1200 (-3.5A)
None
ADP  A1200 ( 4.0A)
ADP  A1200 (-4.7A)
ADP  A1200 (-3.4A)
 0.49A 5aacA-5lpzA:
23.1		 5aacA-5lpzA:
26.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 593
VAL A 601
ALA A 617
LEU A 671
MET A 674
GLY A 677
ASP A 741
 7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
7AE  A1000 (-3.7A)
None
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
 0.38A 5aacA-5td2A:
21.2		 5aacA-5td2A:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 542
VAL A 550
ALA A 565
LEU A 620
MET A 623
GLY A 626
ASP A 690
 7YS  A9001 (-4.1A)
7YS  A9001 (-4.2A)
7YS  A9001 (-3.3A)
7YS  A9001 (-4.2A)
7YS  A9001 (-4.7A)
7YS  A9001 (-3.4A)
None
 0.57A 5aacA-5u6bA:
30.2		 5aacA-5u6bA:
40.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 542
VAL A 550
ALA A 565
LYS A 567
LEU A 620
MET A 623
GLY A 626
 7YS  A9001 (-4.1A)
7YS  A9001 (-4.2A)
7YS  A9001 (-3.3A)
None
7YS  A9001 (-4.2A)
7YS  A9001 (-4.7A)
7YS  A9001 (-3.4A)
 0.66A 5aacA-5u6bA:
30.2		 5aacA-5u6bA:
40.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 VAL A 205
ALA A 218
LEU A 271
MET A 274
GLY A 277
LEU A 324
ASP A 335
 QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
QRW  A 601 ( 4.9A)
MES  A 604 (-3.9A)
None
None
QRW  A 601 (-3.7A)
 0.88A 5aacA-5uuuA:
22.3		 5aacA-5uuuA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 VAL A 205
ALA A 218
LYS A 220
LEU A 271
MET A 274
GLY A 277
LEU A 324
 QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
QRW  A 601 (-3.0A)
QRW  A 601 ( 4.9A)
MES  A 604 (-3.9A)
None
None
 0.96A 5aacA-5uuuA:
22.3		 5aacA-5uuuA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 7 LEU A  24
VAL A  32
ALA A  45
LYS A  47
MET A  98
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.72A 5aacA-5w5jA:
22.9		 5aacA-5w5jA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 6 VAL A  36
ALA A  49
MET A  99
GLY A 102
LEU A 150
ASP A 161
 VX6  A 402 (-4.6A)
VX6  A 402 (-3.2A)
None
VX6  A 402 (-3.5A)
VX6  A 402 (-4.4A)
VX6  A 402 (-4.3A)
 0.53A 5aacA-5wnmA:
28.4		 5aacA-5wnmA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 LEU A 891
VAL A 899
ALA A 917
LYS A 919
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.50A 5aacA-5wnoA:
27.5		 5aacA-5wnoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 6 LEU A  33
VAL A  41
ALA A  54
LYS A  56
GLY A 105
LEU A 153
 ANP  A 501 ( 3.8A)
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-2.4A)
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
 0.52A 5aacA-6ao5A:
22.5		 5aacA-6ao5A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 LEU A 881
VAL A 889
ALA A 906
GLY A 962
LEU A1010
GLY A1020
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
None
MG  A1203 (-1.8A)
 0.61A 5aacA-6c7yA:
28.9		 5aacA-6c7yA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLY A 962
LEU A1010
GLY A1020
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
None
 0.81A 5aacA-6c7yA:
28.9		 5aacA-6c7yA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 7 LEU A 275
VAL A 283
ALA A 296
LYS A 298
GLY A 349
GLY A 410
ASP A 411
 FE7  A 601 (-3.8A)
FE7  A 601 ( 4.3A)
FE7  A 601 (-3.3A)
FE7  A 601 (-3.6A)
FE7  A 601 ( 3.7A)
FE7  A 601 ( 4.1A)
MG  A 602 ( 2.6A)
 0.83A 5aacA-6cthA:
22.2		 5aacA-6cthA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 7 LEU A 197
VAL A 205
ALA A 217
LYS A 219
MET A 267
GLY A 270
LEU A 319
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.76A 5aacA-6cz4A:
29.7		 5aacA-6cz4A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 7 LEU A 197
VAL A 205
ALA A 217
MET A 267
GLY A 270
LEU A 319
GLY A 329
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
FKY  A9001 (-3.4A)
 0.74A 5aacA-6cz4A:
29.7		 5aacA-6cz4A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 7 VAL A 200
ALA A 211
LYS A 213
MET A 265
GLY A 268
LEU A 318
ASP A 329
 CJT  A 502 ( 4.8A)
CJT  A 502 (-3.4A)
CJT  A 502 (-3.0A)
CJT  A 502 (-4.9A)
CJT  A 502 ( 4.3A)
CJT  A 502 (-4.7A)
CJT  A 502 ( 4.0A)
 0.70A 5aacA-6f3dA:
24.0		 5aacA-6f3dA:
13.70