SIMILAR PATTERNS OF AMINO ACIDS FOR 5AAB_A_VGHA9000_1

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1k9a	CARBOXYL-TERMINAL SRC KINASE (Rattus norvegicus)	PF00017 (SH2) PF00018 (SH3_1) PF07714 (Pkinase_Tyr)	7	VAL A 209 ALA A 220 LYS A 222 MET A 269 GLY A 272 LEU A 321 ASP A 332	None	0.84A	5aabA-1k9aA: 32.6	5aabA-1k9aA: 25.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1luf	MUSCLE-SPECIFIC TYROSINE KINASE RECEPTOR MUSK (Rattus norvegicus)	PF07714 (Pkinase_Tyr)	7	VAL A 588 ALA A 606 LYS A 608 MET A 657 GLY A 660 LEU A 731 ASP A 742	None	0.86A	5aabA-1lufA: 32.7	5aabA-1lufA: 35.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1opk	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 (Mus musculus)	PF00017 (SH2) PF00018 (SH3_1) PF07714 (Pkinase_Tyr)	7	LEU A 267 VAL A 275 ALA A 288 LYS A 290 MET A 337 GLY A 340 LEU A 389	P16  A   2 ( 4.2A) P16  A   2 (-4.5A) P16  A   2 (-3.4A) P16  A   2 (-4.5A) None P16  A   2 (-3.4A) P16  A   2 (-4.4A)	0.65A	5aabA-1opkA: 31.0	5aabA-1opkA: 26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1s9i	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2 (Homo sapiens)	PF00069 (Pkinase)	7	LEU A  78 VAL A  86 ALA A  99 LYS A 101 MET A 150 GLY A 153 LEU A 201	ATP  A 535 (-3.9A) ATP  A 535 (-4.1A) ATP  A 535 (-3.6A) ATP  A 535 ( 2.5A) None ATP  A 535 ( 4.7A) ATP  A 535 (-4.8A)	0.62A	5aabA-1s9iA: 22.1	5aabA-1s9iA: 25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1u5q	SERINE/THREONINE PROTEIN KINASE TAO2 (Rattus norvegicus)	PF00069 (Pkinase)	7	VAL A  42 ALA A  55 LYS A  57 GLY A 110 LEU A 158 GLY A 168 ASP A 169	None	0.84A	5aabA-1u5qA: 25.1	5aabA-1u5qA: 29.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1zlt	SERINE/THREONINE-PRO TEIN KINASE CHK1 (Homo sapiens)	PF00069 (Pkinase)	8	LEU A  15 VAL A  23 ALA A  36 LYS A  38 LEU A  84 GLY A  90 LEU A 137 ASP A 148	HYM  A 400 (-4.2A) HYM  A 400 (-4.3A) HYM  A 400 (-3.5A) HYM  A 400 (-3.2A) HYM  A 400 (-4.2A) None HYM  A 400 (-4.5A) HYM  A 400 (-3.9A)	0.95A	5aabA-1zltA: 21.1	5aabA-1zltA: 24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2buj	SERINE/THREONINE-PRO TEIN KINASE 16 (Homo sapiens)	PF00069 (Pkinase)	8	LEU A  26 VAL A  34 ALA A  47 LYS A  49 LEU A  98 GLY A 104 LEU A 155 ASP A 166	STU  A1301 (-4.2A) STU  A1301 (-4.8A) STU  A1301 (-3.6A) STU  A1301 ( 4.0A) STU  A1301 ( 4.7A) STU  A1301 ( 4.0A) STU  A1301 ( 4.8A) None	0.79A	5aabA-2bujA: 23.9	5aabA-2bujA: 24.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2dq7	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FYN (Homo sapiens)	PF07714 (Pkinase_Tyr)	8	LEU X  17 VAL X  25 ALA X  37 LYS X  39 MET X  85 GLY X  88 LEU X 137 ASP X 148	STU  X 902 (-3.8A) STU  X 902 ( 4.8A) STU  X 902 (-3.1A) STU  X 902 (-3.1A) None STU  X 902 (-3.5A) STU  X 902 (-4.4A) STU  X 902 (-3.6A)	0.81A	5aabA-2dq7X: 31.7	5aabA-2dq7X: 37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2f9g	MITOGEN-ACTIVATED PROTEIN KINASE FUS3 (Saccharomyces cerevisiae)	PF00069 (Pkinase)	7	LEU A  19 VAL A  27 ALA A  40 LYS A  42 MET A  96 LEU A 144 ASP A 155	ADP  A 500 (-4.3A) ADP  A 500 (-4.3A) ADP  A 500 ( 3.7A) ADP  A 500 (-2.9A) None ADP  A 500 (-4.3A) ADP  A 500 ( 2.9A)	0.92A	5aabA-2f9gA: 22.4	5aabA-2f9gA: 23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2h8h	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	PF00017 (SH2) PF00018 (SH3_1) PF07714 (Pkinase_Tyr)	7	LEU A 273 VAL A 281 ALA A 293 LYS A 295 MET A 341 GLY A 344 LEU A 393	H8H  A 534 (-3.8A) H8H  A 534 (-4.4A) H8H  A 534 (-3.2A) H8H  A 534 (-3.7A) None H8H  A 534 (-3.3A) H8H  A 534 (-4.5A)	0.49A	5aabA-2h8hA: 30.2	5aabA-2h8hA: 22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2h8h	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	PF00017 (SH2) PF00018 (SH3_1) PF07714 (Pkinase_Tyr)	7	LEU A 273 VAL A 281 ALA A 293 MET A 341 GLY A 344 LEU A 393 ASP A 404	H8H  A 534 (-3.8A) H8H  A 534 (-4.4A) H8H  A 534 (-3.2A) None H8H  A 534 (-3.3A) H8H  A 534 (-4.5A) H8H  A 534 (-4.2A)	0.59A	5aabA-2h8hA: 30.2	5aabA-2h8hA: 22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2hck	HEMATOPOETIC CELL KINASE HCK (Homo sapiens)	PF00017 (SH2) PF00018 (SH3_1) PF07714 (Pkinase_Tyr)	7	LEU A 273 VAL A 281 ALA A 293 LYS A 295 MET A 341 GLY A 344 LEU A 393	QUE  A   1 (-3.9A) QUE  A   1 ( 4.8A) QUE  A   1 (-3.5A) None None QUE  A   1 (-3.0A) QUE  A   1 (-4.4A)	0.64A	5aabA-2hckA: 29.2	5aabA-2hckA: 26.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2hk5	TYROSINE-PROTEIN KINASE HCK (Homo sapiens)	PF07714 (Pkinase_Tyr)	8	LEU A 251 VAL A 259 ALA A 271 LYS A 273 MET A 319 GLY A 322 LEU A 371 ASP A 382	1BM  A 499 ( 3.7A) 1BM  A 499 ( 4.8A) 1BM  A 499 (-3.6A) 1BM  A 499 (-3.8A) None 1BM  A 499 (-3.5A) 1BM  A 499 (-4.4A) 1BM  A 499 (-4.4A)	0.71A	5aabA-2hk5A: 31.9	5aabA-2hk5A: 37.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2hz0	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 (Homo sapiens)	PF07714 (Pkinase_Tyr)	8	LEU A 248 VAL A 256 ALA A 269 LYS A 271 MET A 318 GLY A 321 LEU A 370 ASP A 381	GIN  A 600 ( 4.6A) GIN  A 600 ( 4.7A) GIN  A 600 (-3.1A) GIN  A 600 (-3.6A) None None GIN  A 600 (-4.7A) GIN  A 600 (-4.9A)	0.89A	5aabA-2hz0A: 30.8	5aabA-2hz0A: 37.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2j0j	FOCAL ADHESION KINASE 1 (Gallus gallus)	PF00373 (FERM_M) PF07714 (Pkinase_Tyr)	7	VAL A 436 ALA A 452 LYS A 454 GLY A 505 LEU A 553 GLY A 563 ASP A 564	4ST  A1687 ( 4.8A) 4ST  A1687 (-3.3A) 4ST  A1687 (-3.4A) 4ST  A1687 (-3.2A) 4ST  A1687 (-4.4A) None 4ST  A1687 (-4.7A)	0.77A	5aabA-2j0jA: 32.8	5aabA-2j0jA: 19.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2og8	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK (Homo sapiens)	PF07714 (Pkinase_Tyr)	7	LEU A 251 VAL A 259 ALA A 271 LYS A 273 MET A 319 GLY A 322 LEU A 371	None None 1N8  A 501 ( 3.4A) 1N8  A 501 ( 3.4A) 1N8  A 501 ( 4.4A) 1N8  A 501 ( 3.5A) 1N8  A 501 ( 4.3A)	0.72A	5aabA-2og8A: 30.3	5aabA-2og8A: 40.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2ogv	MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR PRECURSOR (Homo sapiens)	PF07714 (Pkinase_Tyr)	7	LEU A 588 VAL A 596 ALA A 614 GLY A 669 LEU A 785 GLY A 795 ASP A 796	None	0.81A	5aabA-2ogvA: 30.7	5aabA-2ogvA: 36.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2phk	PHOSPHORYLASE KINASE (Oryctolagus cuniculus)	PF00069 (Pkinase)	8	LEU A  25 VAL A  33 ALA A  46 LYS A  48 MET A 106 GLY A 109 LEU A 156 ASP A 167	ATP  A 381 ( 4.3A) ATP  A 381 (-4.1A) ATP  A 381 (-3.5A) ATP  A 381 (-3.2A) None None ATP  A 381 ( 4.8A) MN  A 382 (-2.0A)	0.81A	5aabA-2phkA: 22.7	5aabA-2phkA: 23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2pmi	CYCLIN-DEPENDENT PROTEIN KINASE PHO85 (Saccharomyces cerevisiae)	PF00069 (Pkinase)	7	VAL A  21 ALA A  34 LYS A  36 MET A  85 LEU A 140 GLY A 150 ASP A 151	AGS  A3001 (-4.4A) AGS  A3001 (-3.5A) AGS  A3001 (-3.4A) None None None AGS  A3001 (-2.8A)	0.82A	5aabA-2pmiA: 15.1	5aabA-2pmiA: 25.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2qob	EPHRIN RECEPTOR (Homo sapiens)	PF07714 (Pkinase_Tyr)	7	VAL A 635 ALA A 651 LYS A 653 MET A 702 GLY A 705 LEU A 753 ASP A 764	BME  A   1 (-4.9A) PTR  A 701 ( 4.7A) None PTR  A 701 ( 3.5A) None None None	0.88A	5aabA-2qobA: 34.2	5aabA-2qobA: 33.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2r4b	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4 (Homo sapiens)	PF07714 (Pkinase_Tyr)	7	LEU A 724 VAL A 732 ALA A 749 LYS A 751 MET A 799 GLY A 802 LEU A 850	GW7  A   1 ( 4.2A) GW7  A   1 ( 4.8A) GW7  A   1 (-3.3A) GW7  A   1 (-3.9A) None GW7  A   1 (-3.6A) GW7  A   1 (-4.2A)	0.56A	5aabA-2r4bA: 30.4	5aabA-2r4bA: 32.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2v55	RHO-ASSOCIATED PROTEIN KINASE 1 (Homo sapiens)	PF00069 (Pkinase)	7	VAL A  90 ALA A 103 LYS A 105 MET A 156 GLY A 159 LEU A 205 ASP A 216	None ANP  A1480 ( 3.9A) ANP  A1480 (-3.4A) None None ANP  A1480 ( 4.7A) ANP  A1480 (-3.5A)	1.01A	5aabA-2v55A: 19.6	5aabA-2v55A: 23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2xk9	CHECKPOINT KINASE 2 (Homo sapiens)	PF00069 (Pkinase)	8	LEU A 226 VAL A 234 ALA A 247 LYS A 249 LEU A 301 MET A 304 GLY A 307 LEU A 354	XK9  A1511 (-3.8A) XK9  A1511 (-4.8A) XK9  A1511 ( 4.1A) XK9  A1511 (-4.2A) XK9  A1511 (-4.6A) None XK9  A1511 ( 3.7A) XK9  A1511 (-4.6A)	0.92A	5aabA-2xk9A: 21.5	5aabA-2xk9A: 25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2y7j	PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER ISOFORM (Homo sapiens)	PF00069 (Pkinase)	7	VAL A  38 ALA A  51 LYS A  53 MET A 110 GLY A 113 LEU A 160 ASP A 171	None B49  A1294 (-3.2A) None None B49  A1294 (-3.6A) B49  A1294 (-4.4A) B49  A1294 (-4.2A)	0.80A	5aabA-2y7jA: 24.0	5aabA-2y7jA: 23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2z7r	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1 (Homo sapiens)	PF00069 (Pkinase)	8	LEU A  68 VAL A  76 ALA A  92 LYS A  94 LEU A 141 GLY A 147 LEU A 194 ASP A 205	STU  A   1 (-3.8A) None STU  A   1 (-3.3A) STU  A   1 (-2.8A) STU  A   1 ( 4.6A) STU  A   1 ( 3.9A) STU  A   1 (-4.6A) STU  A   1 ( 3.8A)	0.84A	5aabA-2z7rA: 21.6	5aabA-2z7rA: 24.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2z8c	INSULIN RECEPTOR (Homo sapiens)	PF07714 (Pkinase_Tyr)	7	LEU A1002 VAL A1010 ALA A1028 MET A1079 GLY A1082 GLY A1149 ASP A1150	S91  A   1 ( 4.1A) S91  A   1 ( 4.9A) S91  A   1 (-3.2A) None S91  A   1 (-3.3A) None None	0.45A	5aabA-2z8cA: 30.4	5aabA-2z8cA: 44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2zv7	TYROSINE-PROTEIN KINASE LYN (Mus musculus)	PF07714 (Pkinase_Tyr)	8	LEU A 253 VAL A 261 ALA A 273 LYS A 275 MET A 322 GLY A 325 LEU A 374 ASP A 385	None	0.74A	5aabA-2zv7A: 32.8	5aabA-2zv7A: 35.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3d7u	TYROSINE-PROTEIN KINASE CSK (Homo sapiens)	PF07714 (Pkinase_Tyr)	7	VAL A 209 ALA A 220 LYS A 222 MET A 269 GLY A 272 LEU A 321 ASP A 332	None	0.84A	5aabA-3d7uA: 26.3	5aabA-3d7uA: 34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3fzp	PROTEIN TYROSINE KINASE 2 BETA (Homo sapiens)	PF07714 (Pkinase_Tyr)	7	LEU A 431 VAL A 439 ALA A 455 LYS A 457 GLY A 508 LEU A 556 GLY A 566	AGS  A 999 ( 4.4A) AGS  A 999 (-4.6A) AGS  A 999 (-3.6A) AGS  A 999 (-2.5A) None AGS  A 999 (-4.5A) None	0.97A	5aabA-3fzpA: 31.7	5aabA-3fzpA: 34.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3i6u	SERINE/THREONINE-PRO TEIN KINASE CHK2 (Homo sapiens)	PF00069 (Pkinase) PF00498 (FHA)	8	LEU A 226 VAL A 234 ALA A 247 LEU A 301 MET A 304 GLY A 307 LEU A 354 ASP A 368	None	0.93A	5aabA-3i6uA: 21.4	5aabA-3i6uA: 22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3lj0	SERINE/THREONINE-PRO TEIN KINASE/ENDORIBONUCLE ASE IRE1 (Saccharomyces cerevisiae)	PF00069 (Pkinase) PF06479 (Ribonuc_2-5A)	7	LEU A 680 VAL A 689 ALA A 700 LYS A 702 LEU A 745 LEU A 804 ASP A 828	ADP  A2101 ( 4.1A) ADP  A2101 (-4.5A) ADP  A2101 (-3.5A) ADP  A2101 (-2.7A) ADP  A2101 ( 4.4A) ADP  A2101 (-4.4A) SR  A2103 (-2.6A)	0.84A	5aabA-3lj0A: 23.1	5aabA-3lj0A: 22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3lm5	SERINE/THREONINE-PRO TEIN KINASE 17B (Homo sapiens)	PF00069 (Pkinase)	7	LEU A  39 VAL A  47 ALA A  60 LYS A  62 LEU A 110 GLY A 116 LEU A 165	QUE  A   1 ( 3.8A) QUE  A   1 ( 4.6A) QUE  A   1 (-3.2A) QUE  A   1 (-4.1A) QUE  A   1 (-4.1A) None None	0.86A	5aabA-3lm5A: 25.1	5aabA-3lm5A: 28.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3lw0	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (Homo sapiens)	PF07714 (Pkinase_Tyr)	7	LEU A1005 VAL A1013 ALA A1031 LYS A1033 MET A1082 GLY A1085 GLY A1152	None None None CCX  A   1 ( 3.7A) None None CCX  A   1 (-3.6A)	0.79A	5aabA-3lw0A: 30.2	5aabA-3lw0A: 41.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3lw0	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (Homo sapiens)	PF07714 (Pkinase_Tyr)	7	LEU A1005 VAL A1013 ALA A1031 LYS A1033 MET A1082 GLY A1152 ASP A1153	None None None CCX  A   1 ( 3.7A) None CCX  A   1 (-3.6A) CCX  A   1 ( 4.3A)	1.01A	5aabA-3lw0A: 30.2	5aabA-3lw0A: 41.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3nuu	PKB-LIKE (Homo sapiens)	PF00069 (Pkinase)	7	LEU A  88 VAL A  96 ALA A 109 LYS A 111 GLY A 165 LEU A 212 ASP A 223	JOZ  A 361 (-4.1A) JOZ  A 361 ( 4.7A) JOZ  A 361 (-3.4A) SO4  A   5 (-2.8A) None None SO4  A   5 ( 4.5A)	0.87A	5aabA-3nuuA: 23.6	5aabA-3nuuA: 23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3nuu	PKB-LIKE (Homo sapiens)	PF00069 (Pkinase)	7	LEU A  88 VAL A  96 ALA A 109 LYS A 111 LEU A 159 GLY A 165 ASP A 223	JOZ  A 361 (-4.1A) JOZ  A 361 ( 4.7A) JOZ  A 361 (-3.4A) SO4  A   5 (-2.8A) JOZ  A 361 (-4.0A) None SO4  A   5 ( 4.5A)	0.94A	5aabA-3nuuA: 23.6	5aabA-3nuuA: 23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3nyo	G PROTEIN-COUPLED RECEPTOR KINASE 6 (Homo sapiens)	PF00069 (Pkinase) PF00615 (RGS)	8	LEU A 192 VAL A 200 ALA A 213 LEU A 263 MET A 266 GLY A 269 LEU A 318 ASP A 329	AMP  A 577 ( 4.3A) AMP  A 577 (-4.3A) AMP  A 577 (-3.4A) AMP  A 577 ( 4.7A) None None AMP  A 577 (-4.8A) AMP  A 577 (-4.0A)	0.60A	5aabA-3nyoA: 22.7	5aabA-3nyoA: 18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3nyo	G PROTEIN-COUPLED RECEPTOR KINASE 6 (Homo sapiens)	PF00069 (Pkinase) PF00615 (RGS)	8	LEU A 192 VAL A 200 ALA A 213 LYS A 215 LEU A 263 MET A 266 GLY A 269 LEU A 318	AMP  A 577 ( 4.3A) AMP  A 577 (-4.3A) AMP  A 577 (-3.4A) AMP  A 577 (-2.8A) AMP  A 577 ( 4.7A) None None AMP  A 577 (-4.8A)	0.68A	5aabA-3nyoA: 22.7	5aabA-3nyoA: 18.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3pp0	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 (Homo sapiens)	PF07714 (Pkinase_Tyr)	7	LEU A 726 VAL A 734 ALA A 751 LYS A 753 MET A 801 GLY A 804 LEU A 852	03Q  A   1 (-3.8A) 03Q  A   1 (-4.5A) 03Q  A   1 (-3.1A) 03Q  A   1 (-4.7A) None 03Q  A   1 ( 3.9A) 03Q  A   1 (-4.4A)	0.56A	5aabA-3pp0A: 31.4	5aabA-3pp0A: 34.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3q5i	PROTEIN KINASE (Plasmodium berghei)	PF00069 (Pkinase) PF13499 (EF-hand_7)	7	LEU A  63 VAL A  71 ALA A  84 LYS A  86 GLY A 150 LEU A 197 ASP A 211	ANP  A1634 ( 4.3A) ANP  A1634 (-4.1A) ANP  A1634 (-3.6A) ANP  A1634 (-3.1A) None ANP  A1634 (-4.4A) MG  A 529 (-2.2A)	0.94A	5aabA-3q5iA: 21.6	5aabA-3q5iA: 22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3she	MAP KINASE-ACTIVATED PROTEIN KINASE 3 (Homo sapiens)	PF00069 (Pkinase)	7	LEU A  50 VAL A  58 ALA A  71 LYS A  73 MET A 121 LEU A 173 ASP A 187	I85  A 350 (-3.7A) I85  A 350 (-4.9A) I85  A 350 (-3.3A) I85  A 350 (-2.8A) None None I85  A 350 (-3.3A)	1.01A	5aabA-3sheA: 19.6	5aabA-3sheA: 23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ulz	BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED RECEPTOR KINASE 1 (Arabidopsis thaliana)	PF00069 (Pkinase)	7	LEU A 295 VAL A 303 ALA A 315 MET A 366 GLY A 369 LEU A 423 GLY A 433	None	0.55A	5aabA-3ulzA: 22.4	5aabA-3ulzA: 28.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3v5q	NT-3 GROWTH FACTOR RECEPTOR (Homo sapiens)	PF07714 (Pkinase_Tyr)	7	LEU A 544 VAL A 552 ALA A 570 LYS A 572 MET A 620 GLY A 623 LEU A 686	0F4  A 902 ( 4.2A) None 0F4  A 902 (-3.2A) 0F4  A 902 (-4.0A) None 0F4  A 902 (-3.4A) 0F4  A 902 (-4.5A)	0.65A	5aabA-3v5qA: 30.8	5aabA-3v5qA: 39.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3v5q	NT-3 GROWTH FACTOR RECEPTOR (Homo sapiens)	PF07714 (Pkinase_Tyr)	7	LEU A 544 VAL A 552 ALA A 570 MET A 620 GLY A 623 LEU A 686 GLY A 696	0F4  A 902 ( 4.2A) None 0F4  A 902 (-3.2A) None 0F4  A 902 (-3.4A) 0F4  A 902 (-4.5A) 0F4  A 902 (-3.3A)	0.66A	5aabA-3v5qA: 30.8	5aabA-3v5qA: 39.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3w18	AURORA KINASE A (Homo sapiens)	PF00069 (Pkinase)	7	LEU A 139 VAL A 147 ALA A 160 LYS A 162 LEU A 210 GLY A 216 LEU A 263	N13  A 501 (-3.7A) N13  A 501 ( 4.7A) N13  A 501 ( 4.1A) N13  A 501 (-2.9A) N13  A 501 ( 4.8A) N13  A 501 (-3.5A) N13  A 501 (-4.5A)	0.75A	5aabA-3w18A: 21.9	5aabA-3w18A: 25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3wig	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (Homo sapiens)	PF00069 (Pkinase)	7	LEU A  75 VAL A  83 ALA A  96 LYS A  98 MET A 147 GLY A 150 LEU A 198	ANP  A 401 (-3.8A) ANP  A 401 ( 4.3A) ANP  A 401 (-3.2A) ANP  A 401 (-2.7A) None ANP  A 401 ( 4.3A) ANP  A 401 (-4.8A)	0.63A	5aabA-3wigA: 23.3	5aabA-3wigA: 24.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3wzd	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Homo sapiens)	PF07714 (Pkinase_Tyr)	7	LEU A 840 VAL A 848 ALA A 866 LYS A 868 GLY A 922 LEU A1035 ASP A1046	LEV  A1201 ( 3.8A) LEV  A1201 ( 4.9A) LEV  A1201 (-3.5A) None LEV  A1201 (-3.6A) LEV  A1201 (-4.8A) GOL  A1210 ( 3.4A)	0.72A	5aabA-3wzdA: 31.5	5aabA-3wzdA: 35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3zbf	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS (Homo sapiens)	PF07714 (Pkinase_Tyr)	10	LEU A1951 VAL A1959 ALA A1978 LYS A1980 LEU A2026 MET A2029 GLY A2032 LEU A2086 GLY A2101 ASP A2102	VGH  A3000 ( 4.4A) None VGH  A3000 (-3.4A) VGH  A3000 ( 4.7A) VGH  A3000 ( 4.2A) None VGH  A3000 (-3.5A) VGH  A3000 (-4.3A) VGH  A3000 (-3.5A) None	0.51A	5aabA-3zbfA: 34.4	5aabA-3zbfA: 47.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3zfx	EPHRIN TYPE-B RECEPTOR 1 (Homo sapiens)	PF07714 (Pkinase_Tyr)	7	VAL A 633 ALA A 649 LYS A 651 MET A 700 GLY A 703 LEU A 751 ASP A 762	None	0.78A	5aabA-3zfxA: 34.5	5aabA-3zfxA: 35.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4af3	AURORA KINASE B (Homo sapiens)	PF00069 (Pkinase)	7	LEU A  83 VAL A  91 ALA A 104 LYS A 106 LEU A 154 GLY A 160 LEU A 207	VX6  A 500 (-3.8A) VX6  A 500 ( 4.8A) VX6  A 500 (-3.4A) VX6  A 500 (-3.3A) None VX6  A 500 (-3.3A) VX6  A 500 (-4.6A)	0.64A	5aabA-4af3A: 19.9	5aabA-4af3A: 24.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4at3	BDNF/NT-3 GROWTH FACTORS RECEPTOR (Homo sapiens)	PF07714 (Pkinase_Tyr)	7	LEU A 560 VAL A 568 ALA A 586 LYS A 588 LEU A 699 GLY A 709 ASP A 710	LTI  A1839 ( 4.2A) None LTI  A1839 (-3.3A) None LTI  A1839 (-4.2A) LTI  A1839 (-3.4A) None	0.83A	5aabA-4at3A: 31.2	5aabA-4at3A: 38.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4at3	BDNF/NT-3 GROWTH FACTORS RECEPTOR (Homo sapiens)	PF07714 (Pkinase_Tyr)	8	LEU A 560 VAL A 568 ALA A 586 MET A 636 GLY A 639 LEU A 699 GLY A 709 ASP A 710	LTI  A1839 ( 4.2A) None LTI  A1839 (-3.3A) None LTI  A1839 (-3.4A) LTI  A1839 (-4.2A) LTI  A1839 (-3.4A) None	0.69A	5aabA-4at3A: 31.2	5aabA-4at3A: 38.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4aw5	EPHRIN TYPE-B RECEPTOR 4 (Homo sapiens)	PF07714 (Pkinase_Tyr)	7	VAL A 105 ALA A 121 LYS A 123 MET A 172 GLY A 175 LEU A 223 ASP A 234	30K  A1365 ( 4.6A) 30K  A1365 (-3.2A) 30K  A1365 (-3.8A) None 30K  A1365 (-3.5A) 30K  A1365 (-4.5A) 30K  A1365 (-3.3A)	0.48A	5aabA-4aw5A: 26.2	5aabA-4aw5A: 34.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4b99	MITOGEN-ACTIVATED PROTEIN KINASE 7 (Homo sapiens)	PF00069 (Pkinase)	8	VAL A  69 ALA A  82 LYS A  84 LEU A 137 MET A 140 LEU A 189 GLY A 199 ASP A 200	R4L  A1394 (-4.0A) R4L  A1394 ( 3.7A) None R4L  A1394 (-3.9A) None R4L  A1394 (-4.5A) R4L  A1394 ( 4.1A) None	0.95A	5aabA-4b99A: 22.2	5aabA-4b99A: 23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4c0t	LIKELY PROTEIN KINASE (Candida albicans)	PF00069 (Pkinase)	7	LEU A 246 VAL A 254 ALA A 267 LYS A 269 GLY A 324 LEU A 371 ASP A 382	None	0.98A	5aabA-4c0tA: 22.5	5aabA-4c0tA: 16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4cfh	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1 (Rattus norvegicus)	PF00069 (Pkinase) PF16579 (AdenylateSensor)	7	LEU A  22 VAL A  30 ALA A  43 LYS A  45 GLY A  99 LEU A 146 ASP A 157	STU  A1550 (-4.3A) None STU  A1550 (-3.1A) STU  A1550 (-3.6A) STU  A1550 (-3.4A) STU  A1550 (-4.3A) STU  A1550 (-3.6A)	1.05A	5aabA-4cfhA: 23.0	5aabA-4cfhA: 21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4crs	SERINE/THREONINE-PRO TEIN KINASE N2 (Homo sapiens)	PF00069 (Pkinase) PF00433 (Pkinase_C)	7	LEU A 663 VAL A 671 ALA A 684 LYS A 686 GLY A 743 LEU A 789 ASP A 800	AGS  A1985 (-4.2A) AGS  A1985 (-4.6A) AGS  A1985 (-3.5A) AGS  A1985 (-3.0A) None AGS  A1985 (-4.8A) AGS  A1985 ( 3.3A)	0.91A	5aabA-4crsA: 21.7	5aabA-4crsA: 26.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4f0i	HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR (Homo sapiens)	PF07714 (Pkinase_Tyr)	8	LEU A 515 VAL A 523 ALA A 541 MET A 591 GLY A 594 LEU A 656 GLY A 666 ASP A 667	None	0.59A	5aabA-4f0iA: 30.9	5aabA-4f0iA: 39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4f4p	TYROSINE-PROTEIN KINASE SYK (Homo sapiens)	PF07714 (Pkinase_Tyr)	7	LEU A 377 VAL A 385 ALA A 400 LYS A 402 GLY A 454 LEU A 501 ASP A 512	0SB  A 701 ( 3.9A) 0SB  A 701 (-4.0A) 0SB  A 701 (-3.3A) 0SB  A 701 ( 4.8A) 0SB  A 701 (-3.5A) 0SB  A 701 (-4.4A) 0SB  A 701 (-3.9A)	0.68A	5aabA-4f4pA: 31.7	5aabA-4f4pA: 32.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4feq	TYROSINE-PROTEIN KINASE RECEPTOR TYRO3 (Mus musculus)	PF07714 (Pkinase_Tyr)	7	LEU A 514 VAL A 522 ALA A 538 LEU A 593 MET A 596 GLY A 599 ASP A 663	0T8  A 901 (-3.6A) 0T8  A 901 ( 4.4A) 0T8  A 901 (-3.2A) 0T8  A 901 (-3.7A) None 0T8  A 901 ( 3.8A) 0T8  A 901 (-4.5A)	0.87A	5aabA-4feqA: 10.7	5aabA-4feqA: 37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4feq	TYROSINE-PROTEIN KINASE RECEPTOR TYRO3 (Mus musculus)	PF07714 (Pkinase_Tyr)	7	LEU A 514 VAL A 522 ALA A 538 LYS A 540 LEU A 593 MET A 596 GLY A 599	0T8  A 901 (-3.6A) 0T8  A 901 ( 4.4A) 0T8  A 901 (-3.2A) 0T8  A 901 (-3.5A) 0T8  A 901 (-3.7A) None 0T8  A 901 ( 3.8A)	0.67A	5aabA-4feqA: 10.7	5aabA-4feqA: 37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4fod	ALK TYROSINE KINASE RECEPTOR (Homo sapiens)	PF07714 (Pkinase_Tyr)	9	LEU A1122 VAL A1130 ALA A1148 LEU A1196 MET A1199 GLY A1202 LEU A1256 GLY A1269 ASP A1270	0UV  A1501 (-3.8A) 0UV  A1501 (-4.5A) 0UV  A1501 (-3.4A) 0UV  A1501 (-3.7A) None 0UV  A1501 (-3.6A) 0UV  A1501 (-4.6A) 0UV  A1501 (-4.5A) 0UV  A1501 ( 4.2A)	0.46A	5aabA-4fodA: 45.4	5aabA-4fodA: 94.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4fod	ALK TYROSINE KINASE RECEPTOR (Homo sapiens)	PF07714 (Pkinase_Tyr)	7	LEU A1122 VAL A1130 ALA A1148 LYS A1150 GLY A1202 LEU A1256 ASP A1270	0UV  A1501 (-3.8A) 0UV  A1501 (-4.5A) 0UV  A1501 (-3.4A) 0UV  A1501 (-3.7A) 0UV  A1501 (-3.6A) 0UV  A1501 (-4.6A) 0UV  A1501 ( 4.2A)	0.98A	5aabA-4fodA: 45.4	5aabA-4fodA: 94.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4gl9	TYROSINE-PROTEIN KINASE (Mus musculus)	PF07714 (Pkinase_Tyr)	7	LEU A 855 ALA A 880 LYS A 882 GLY A 935 LEU A 983 GLY A 993 ASP A 994	IZA  A2001 (-3.7A) IZA  A2001 (-3.4A) IZA  A2001 ( 4.7A) IZA  A2001 (-3.3A) IZA  A2001 ( 4.7A) None IZA  A2001 ( 4.5A)	0.72A	5aabA-4gl9A: 29.1	5aabA-4gl9A: 30.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4gl9	TYROSINE-PROTEIN KINASE (Mus musculus)	PF07714 (Pkinase_Tyr)	7	LEU A 855 VAL A 863 ALA A 880 LYS A 882 GLY A 935 LEU A 983 GLY A 993	IZA  A2001 (-3.7A) None IZA  A2001 (-3.4A) IZA  A2001 ( 4.7A) IZA  A2001 (-3.3A) IZA  A2001 ( 4.7A) None	0.68A	5aabA-4gl9A: 29.1	5aabA-4gl9A: 30.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4hvi	TYROSINE-PROTEIN KINASE JAK3 (Homo sapiens)	PF07714 (Pkinase_Tyr)	7	LEU A 828 VAL A 836 ALA A 853 LYS A 855 GLY A 908 LEU A 956 ASP A 967	19S  A1201 (-3.9A) 19S  A1201 (-4.4A) 19S  A1201 (-3.3A) 19S  A1201 (-3.5A) 19S  A1201 ( 3.8A) 19S  A1201 (-4.5A) 19S  A1201 ( 4.1A)	0.85A	5aabA-4hviA: 23.4	5aabA-4hviA: 29.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4hzs	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	PF07714 (Pkinase_Tyr) PF14604 (SH3_9)	8	LEU A 132 VAL A 140 ALA A 156 LYS A 158 GLY A 211 LEU A 259 GLY A 269 ASP A 270	None	0.68A	5aabA-4hzsA: 28.6	5aabA-4hzsA: 33.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4id7	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	PF07714 (Pkinase_Tyr)	8	LEU A 132 VAL A 140 ALA A 156 LYS A 158 GLY A 211 LEU A 259 GLY A 269 ASP A 270	1G0  A 401 ( 4.5A) 1G0  A 401 (-4.4A) 1G0  A 401 (-3.6A) 1G0  A 401 (-3.7A) 1G0  A 401 ( 4.5A) 1G0  A 401 (-4.6A) None None	0.72A	5aabA-4id7A: 31.0	5aabA-4id7A: 33.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4jrn	RHOPTRY KINASE FAMILY PROTEIN (Toxoplasma gondii)	PF14531 (Kinase-like)	7	LEU A 258 VAL A 266 ALA A 279 LYS A 281 LEU A 416 GLY A 426 ASP A 427	ANP  A 601 ( 4.6A) ANP  A 601 (-4.1A) ANP  A 601 ( 3.9A) ANP  A 601 (-3.2A) ANP  A 601 ( 4.9A) None MG  A 603 ( 2.0A)	0.89A	5aabA-4jrnA: 20.0	5aabA-4jrnA: 23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4jxf	SERINE/THREONINE-PRO TEIN KINASE PLK4 (Homo sapiens)	PF00069 (Pkinase)	7	LEU A  18 VAL A  26 ALA A  39 LYS A  41 LEU A  89 GLY A  95 LEU A 143	631  A 301 (-3.4A) 631  A 301 (-4.6A) 631  A 301 (-3.3A) 631  A 301 (-2.7A) 631  A 301 ( 4.5A) 631  A 301 ( 3.7A) 631  A 301 (-4.0A)	0.65A	5aabA-4jxfA: 18.9	5aabA-4jxfA: 24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4k11	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	PF00017 (SH2) PF00018 (SH3_1) PF07714 (Pkinase_Tyr)	7	LEU A 273 VAL A 281 ALA A 293 LYS A 295 MET A 341 GLY A 344 LEU A 393	0J9  A 601 (-4.0A) 0J9  A 601 (-4.4A) 0J9  A 601 (-3.3A) 0J9  A 601 ( 4.7A) None 0J9  A 601 ( 4.1A) 0J9  A 601 (-4.5A)	0.61A	5aabA-4k11A: 30.1	5aabA-4k11A: 26.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4k33	FIBROBLAST GROWTH FACTOR RECEPTOR 3 (Homo sapiens)	PF07714 (Pkinase_Tyr)	7	LEU A 478 VAL A 486 ALA A 506 LYS A 508 GLY A 561 LEU A 624 ASP A 635	ACP  A 801 (-3.8A) ACP  A 801 (-4.2A) ACP  A 801 (-3.3A) ACP  A 801 (-2.7A) ACP  A 801 ( 4.6A) ACP  A 801 (-4.4A) MG  A 802 ( 3.0A)	0.80A	5aabA-4k33A: 32.4	5aabA-4k33A: 38.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4lgg	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Gallus gallus)	PF07714 (Pkinase_Tyr)	7	LEU A 273 VAL A 281 ALA A 293 LYS A 295 MET A 341 GLY A 344 LEU A 393	VGG  A 601 (-3.2A) VGG  A 601 ( 3.5A) VGG  A 601 (-3.5A) VGG  A 601 (-3.8A) None VGG  A 601 ( 3.2A) VGG  A 601 (-4.5A)	0.70A	5aabA-4lggA: 30.1	5aabA-4lggA: 33.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4o38	CYCLIN-G-ASSOCIATED KINASE (Homo sapiens)	PF00069 (Pkinase)	7	LEU A  46 VAL A  54 ALA A  67 LYS A  69 GLY A 128 LEU A 180 ASP A 191	SIN  A 401 ( 3.9A) None SIN  A 401 ( 3.7A) None SIN  A 401 (-3.5A) SIN  A 401 ( 4.5A) None	0.75A	5aabA-4o38A: 20.6	5aabA-4o38A: 24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4oli	NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2 (Homo sapiens)	PF07714 (Pkinase_Tyr)	7	LEU A 903 ALA A 928 LYS A 930 GLY A 984 LEU A1030 GLY A1040 ASP A1041	2TT  A1202 (-3.5A) 2TT  A1202 ( 3.9A) None 2TT  A1202 (-3.4A) 2TT  A1202 (-4.4A) 2TT  A1202 (-3.4A) 2TT  A1202 (-4.6A)	0.76A	5aabA-4oliA: 27.5	5aabA-4oliA: 22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4tnb	G PROTEIN-COUPLED RECEPTOR KINASE 5 (Homo sapiens)	PF00069 (Pkinase) PF00615 (RGS)	7	LEU A 192 VAL A 200 ALA A 213 LYS A 215 LEU A 263 MET A 266 LEU A 318	SGV  A 601 (-4.1A) SGV  A 601 ( 4.6A) SGV  A 601 (-3.3A) SGV  A 601 ( 4.2A) SGV  A 601 (-4.5A) None SGV  A 601 (-4.9A)	1.04A	5aabA-4tnbA: 16.3	5aabA-4tnbA: 19.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4ueu	TYROSINE KINASE AS - A COMMON ANCESTOR OF SRC AND ABL (synthetic construct)	PF07714 (Pkinase_Tyr)	8	LEU A  14 VAL A  22 ALA A  35 LYS A  37 MET A  84 GLY A  87 LEU A 136 ASP A 147	ACP  A1264 ( 4.5A) ACP  A1264 (-4.7A) ACP  A1264 (-2.9A) None None ACP  A1264 (-3.5A) ACP  A1264 ( 4.8A) None	0.56A	5aabA-4ueuA: 32.5	5aabA-4ueuA: 40.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4wb7	DNAJ HOMOLOG SUBFAMILY B MEMBER 1,CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA (Homo sapiens)	PF00069 (Pkinase) PF00226 (DnaJ)	7	LEU A 104 VAL A 112 ALA A 125 LYS A 127 GLY A 181 LEU A 228 ASP A 239	ATP  A 501 ( 4.3A) ATP  A 501 (-4.0A) ATP  A 501 (-3.4A) ATP  A 501 (-2.6A) None ATP  A 501 (-4.5A) ZN  A 503 (-1.9A)	1.00A	5aabA-4wb7A: 22.5	5aabA-4wb7A: 22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4wbo	RHODOPSIN KINASE (Bos taurus)	PF00069 (Pkinase) PF00615 (RGS)	8	LEU A 193 VAL A 201 ALA A 214 LYS A 216 MET A 267 GLY A 270 LEU A 321 ASP A 332	ANW  A 601 ( 4.0A) None ANW  A 601 (-3.4A) None None ANW  A 601 ( 4.5A) ANW  A 601 (-4.9A) None	0.63A	5aabA-4wboA: 23.3	5aabA-4wboA: 22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4xey	TYROSINE-PROTEIN KINASE ABL1 (Homo sapiens)	no annotation	7	LEU B 267 VAL B 275 ALA B 288 LYS B 290 MET B 337 GLY B 340 LEU B 389	1N1  B 601 (-3.7A) 1N1  B 601 ( 4.9A) 1N1  B 601 (-3.5A) 1N1  B 601 (-4.6A) None 1N1  B 601 (-3.5A) 1N1  B 601 (-4.3A)	0.41A	5aabA-4xeyB: 24.8	5aabA-4xeyB: 32.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4y93	NON-SPECIFIC PROTEIN-TYROSINE KINASE,NON-SPECIFIC PROTEIN-TYROSINE KINASE (Bos taurus)	PF00169 (PH) PF00779 (BTK) PF07714 (Pkinase_Tyr)	7	LEU A 408 VAL A 416 ALA A 428 LYS A 430 MET A 477 GLY A 480 LEU A 528	746  A 702 (-3.8A) 746  A 702 ( 4.3A) 746  A 702 (-2.4A) 746  A 702 (-3.7A) None 746  A 702 (-3.6A) 746  A 702 (-4.4A)	0.77A	5aabA-4y93A: 31.8	5aabA-4y93A: 26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4yhj	G PROTEIN-COUPLED RECEPTOR KINASE 4 (Homo sapiens)	PF00069 (Pkinase) PF00615 (RGS)	8	LEU A 193 VAL A 201 ALA A 214 LYS A 216 LEU A 264 MET A 267 LEU A 319 ASP A 330	AN2  A 601 ( 4.2A) AN2  A 601 (-4.0A) AN2  A 601 (-3.6A) AN2  A 601 ( 3.9A) AN2  A 601 ( 4.8A) None None AN2  A 601 (-3.0A)	0.87A	5aabA-4yhjA: 21.3	5aabA-4yhjA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4yhj	G PROTEIN-COUPLED RECEPTOR KINASE 4 (Homo sapiens)	PF00069 (Pkinase) PF00615 (RGS)	7	LEU A 193 VAL A 201 LYS A 216 MET A 267 GLY A 270 LEU A 319 ASP A 330	AN2  A 601 ( 4.2A) AN2  A 601 (-4.0A) AN2  A 601 ( 3.9A) None None None AN2  A 601 (-3.0A)	0.97A	5aabA-4yhjA: 21.3	5aabA-4yhjA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5eyk	AURORA KINASE B-A (Xenopus laevis)	PF00069 (Pkinase)	7	LEU A  99 VAL A 107 ALA A 120 LYS A 122 LEU A 170 GLY A 176 LEU A 223	5U5  A 401 (-3.8A) 5U5  A 401 ( 4.3A) 5U5  A 401 (-3.5A) 5U5  A 401 (-2.6A) 5U5  A 401 (-3.8A) 5U5  A 401 (-3.4A) 5U5  A 401 (-4.7A)	0.81A	5aabA-5eykA: 24.5	5aabA-5eykA: 27.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5f1z	NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2 (Homo sapiens)	PF07714 (Pkinase_Tyr)	7	LEU A 903 VAL A 911 ALA A 928 LYS A 930 GLY A 984 LEU A1030 GLY A1040	5U3  A1200 (-3.8A) 5U3  A1200 ( 4.4A) 5U3  A1200 (-3.5A) None 5U3  A1200 (-3.2A) 5U3  A1200 (-4.4A) 5U3  A1200 ( 4.9A)	0.72A	5aabA-5f1zA: 28.0	5aabA-5f1zA: 31.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5hu3	CALCIUM/CALMODULIN-D EPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN (Drosophila melanogaster)	PF00069 (Pkinase)	7	LEU A  20 VAL A  28 ALA A  41 LYS A  43 GLY A  96 LEU A 143 ASP A 157	ADP  A 301 ( 4.0A) ADP  A 301 (-3.7A) ADP  A 301 (-3.5A) ADP  A 301 (-2.7A) None ADP  A 301 (-4.7A) MG  A 302 ( 3.3A)	0.98A	5aabA-5hu3A: 24.7	5aabA-5hu3A: 25.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5j9z	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	PF07714 (Pkinase_Tyr)	7	LEU A 718 VAL A 726 ALA A 743 LYS A 745 MET A 793 GLY A 796 ASP A 855	6HJ  A1101 ( 4.6A) 6HJ  A1101 ( 4.7A) 6HJ  A1101 (-3.1A) 6HJ  A1101 (-4.2A) None 6HJ  A1101 ( 4.5A) 6HJ  A1101 (-4.3A)	0.75A	5aabA-5j9zA: 32.6	5aabA-5j9zA: 31.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5j9z	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	PF07714 (Pkinase_Tyr)	7	LEU A 718 VAL A 726 ALA A 743 LYS A 745 MET A 793 GLY A 796 LEU A 844	6HJ  A1101 ( 4.6A) 6HJ  A1101 ( 4.7A) 6HJ  A1101 (-3.1A) 6HJ  A1101 (-4.2A) None 6HJ  A1101 ( 4.5A) 6HJ  A1101 ( 4.8A)	0.54A	5aabA-5j9zA: 32.6	5aabA-5j9zA: 31.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5lpy	PROTEIN BRASSINOSTEROID INSENSITIVE 1 (Arabidopsis thaliana)	PF00069 (Pkinase)	7	VAL A 897 ALA A 909 LYS A 911 MET A 959 GLY A 962 LEU A1016 ASP A1027	ATP  A1200 ( 4.5A) ATP  A1200 (-3.5A) ATP  A1200 (-3.8A) None ATP  A1200 ( 4.0A) ATP  A1200 (-4.6A) ATP  A1200 (-4.1A)	0.69A	5aabA-5lpyA: 23.3	5aabA-5lpyA: 26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5lpz	PROTEIN BRASSINOSTEROID INSENSITIVE 1 (Arabidopsis thaliana)	PF00069 (Pkinase)	7	VAL A 897 ALA A 909 LYS A 911 MET A 959 GLY A 962 LEU A1016 ASP A1027	ADP  A1200 (-4.4A) ADP  A1200 (-3.5A) ADP  A1200 ( 4.3A) None ADP  A1200 ( 4.0A) ADP  A1200 (-4.7A) ADP  A1200 (-3.4A)	0.69A	5aabA-5lpzA: 23.3	5aabA-5lpzA: 26.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5td2	TYROSINE-PROTEIN KINASE MER (Homo sapiens)	PF07714 (Pkinase_Tyr)	7	LEU A 593 VAL A 601 ALA A 617 LEU A 671 MET A 674 GLY A 677 ASP A 741	7AE  A1000 ( 3.9A) 7AE  A1000 ( 4.9A) 7AE  A1000 (-3.3A) 7AE  A1000 (-3.7A) None 7AE  A1000 ( 3.7A) 7AE  A1000 (-4.4A)	0.51A	5aabA-5td2A: 21.1	5aabA-5td2A: 38.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5tur	SERINE/THREONINE-PRO TEIN KINASE PIM-1 (Homo sapiens)	no annotation	7	LEU A  44 VAL A  52 ALA A  65 LYS A  67 LEU A 120 LEU A 174 ASP A 186	None 7LK  A 401 (-4.9A) 7LK  A 401 (-3.3A) None 7LK  A 401 (-4.0A) 7LK  A 401 (-4.8A) None	0.97A	5aabA-5turA: 21.7	5aabA-5turA: 23.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5u6b	TYROSINE-PROTEIN KINASE RECEPTOR UFO (Homo sapiens)	PF07714 (Pkinase_Tyr)	8	LEU A 542 VAL A 550 ALA A 565 LYS A 567 LEU A 620 MET A 623 GLY A 626 ASP A 690	7YS  A9001 (-4.1A) 7YS  A9001 (-4.2A) 7YS  A9001 (-3.3A) None 7YS  A9001 (-4.2A) 7YS  A9001 (-4.7A) 7YS  A9001 (-3.4A) None	0.61A	5aabA-5u6bA: 30.4	5aabA-5u6bA: 40.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5u7q	RHO-ASSOCIATED PROTEIN KINASE 2 (Homo sapiens)	PF00069 (Pkinase)	7	VAL A 106 ALA A 119 LYS A 121 MET A 172 GLY A 175 LEU A 221 ASP A 232	None	0.84A	5aabA-5u7qA: 20.5	5aabA-5u7qA: 23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6c7y	TYROSINE-PROTEIN KINASE JAK1 (Homo sapiens)	no annotation	8	LEU A 881 VAL A 889 ALA A 906 LYS A 908 GLY A 962 LEU A1010 GLY A1020 ASP A1021	ADP  A1201 ( 4.5A) ADP  A1201 (-4.3A) ADP  A1201 (-3.4A) ADP  A1201 (-2.8A) ADP  A1201 ( 4.1A) ADP  A1201 (-4.5A) None MG  A1203 (-1.8A)	0.80A	5aabA-6c7yA: 28.9	5aabA-6c7yA: 15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6cth	CONCANAVALIN A-LIKE LECTIN PROTEIN KINASE FAMILY PROTEIN (Theobroma cacao)	no annotation	7	LEU A 275 VAL A 283 ALA A 296 LYS A 298 GLY A 349 GLY A 410 ASP A 411	FE7  A 601 (-3.8A) FE7  A 601 ( 4.3A) FE7  A 601 (-3.3A) FE7  A 601 (-3.6A) FE7  A 601 ( 3.7A) FE7  A 601 ( 4.1A) MG  A 602 ( 2.6A)	0.86A	5aabA-6cthA: 22.3	5aabA-6cthA: 14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6cz4	PROTEIN-TYROSINE KINASE 6 (Homo sapiens)	no annotation	7	LEU A 197 VAL A 205 ALA A 217 LYS A 219 MET A 267 GLY A 270 LEU A 319	FKY  A9001 (-4.1A) FKY  A9001 ( 4.6A) FKY  A9001 (-3.3A) None None FKY  A9001 (-3.3A) FKY  A9001 ( 4.9A)	0.94A	5aabA-6cz4A: 29.7	5aabA-6cz4A: 19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6cz4	PROTEIN-TYROSINE KINASE 6 (Homo sapiens)	no annotation	7	LEU A 197 VAL A 205 ALA A 217 MET A 267 GLY A 270 LEU A 319 GLY A 329	FKY  A9001 (-4.1A) FKY  A9001 ( 4.6A) FKY  A9001 (-3.3A) None FKY  A9001 (-3.3A) FKY  A9001 ( 4.9A) FKY  A9001 (-3.4A)	0.89A	5aabA-6cz4A: 29.7	5aabA-6cz4A: 19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6f3d	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 (Homo sapiens)	no annotation	7	VAL A 200 ALA A 211 LYS A 213 MET A 265 GLY A 268 LEU A 318 ASP A 329	CJT  A 502 ( 4.8A) CJT  A 502 (-3.4A) CJT  A 502 (-3.0A) CJT  A 502 (-4.9A) CJT  A 502 ( 4.3A) CJT  A 502 (-4.7A) CJT  A 502 ( 4.0A)	0.58A	5aabA-6f3dA: 24.3	5aabA-6f3dA: 13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6fdy	- (-)	no annotation	7	LEU U  20 VAL U  28 ALA U  42 LYS U  44 GLY U  97 LEU U 144 ASP U 157	DB8  U 301 (-3.7A) DB8  U 301 ( 4.8A) DB8  U 301 (-3.6A) DB8  U 301 ( 4.0A) DB8  U 301 ( 4.1A) DB8  U 301 (-4.8A) DB8  U 301 (-3.6A)	0.78A	5aabA-6fdyU: 22.3	5aabA-6fdyU: undetectable