SIMILAR PATTERNS OF AMINO ACIDS FOR 5A6I_A_TCWA1124_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g3n V-CYCLIN

(Human
gammaherpesvirus
8) 		PF00134
(Cyclin_N)
PF09080
(K-cyclin_vir_C) 		4 LEU C 192
ALA C 200
SER C 195
VAL C 221
 None
 1.21A 5a6iA-1g3nC:
undetectable		 5a6iA-1g3nC:
18.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		4 LEU A  17
ALA A 108
LEU A 110
SER A 117
 None
 0.74A 5a6iA-1gkeA:
21.3		 5a6iA-1gkeA:
82.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		4 LEU A  17
ALA A 108
LEU A 110
VAL A 121
 None
 0.47A 5a6iA-1gkeA:
21.3		 5a6iA-1gkeA:
82.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
ALA A 108
VAL A 121
 None
 0.63A 5a6iA-1gkeA:
21.3		 5a6iA-1gkeA:
82.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hwn EBULIN

(Sambucus ebulus) 		PF00161
(RIP) 		4 LEU A 202
LEU A 206
SER A 207
VAL A 230
 None
 1.15A 5a6iA-1hwnA:
0.1		 5a6iA-1hwnA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt9 DIADENOSINE
TETRAPHOSPHATE
HYDROLASE

(Caenorhabditis
elegans) 		PF00293
(NUDIX) 		4 LYS A  86
ALA A   6
LEU A   8
VAL A  39
 None
 0.83A 5a6iA-1kt9A:
0.0		 5a6iA-1kt9A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1

(Saccharomyces
cerevisiae) 		PF00025
(Arf) 		4 ALA A 126
LEU A 135
SER A 136
VAL A 124
 None
 1.19A 5a6iA-1mozA:
0.0		 5a6iA-1mozA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgs PEPTIDE-N(4)-(N-ACET
YL-BETA-D-GLUCOSAMIN
YL)ASPARAGINE
AMIDASE F

(Elizabethkingia
meningoseptica) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 LEU A 264
LEU A 268
SER A 271
VAL A 312
 None
 0.82A 5a6iA-1pgsA:
undetectable		 5a6iA-1pgsA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcq CATABOLIC ALANINE
RACEMASE DADX

(Pseudomonas
aeruginosa) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 LEU A 225
ALA A  20
LEU A 197
SER A 193
 None
None
None
PLP  A 358 (-2.6A)
 1.23A 5a6iA-1rcqA:
undetectable		 5a6iA-1rcqA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT

(Thauera
aromatica) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 LEU B 252
ALA B 240
LEU B 242
SER B 219
 None
 0.96A 5a6iA-1sb3B:
0.0		 5a6iA-1sb3B:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjj ACTININ

(Gallus gallus) 		PF00307
(CH)
PF00435
(Spectrin)
PF08726
(EFhand_Ca_insen) 		4 LEU A 505
ALA A 426
LEU A 428
SER A 429
 None
 1.22A 5a6iA-1sjjA:
undetectable		 5a6iA-1sjjA:
8.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata) 		PF00576
(Transthyretin) 		4 LEU A  17
ALA A 108
LEU A 110
VAL A 121
 None
 0.38A 5a6iA-1sn2A:
20.5		 5a6iA-1sn2A:
52.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxr PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		4 ALA A 127
LEU A 125
SER A 121
VAL A  86
 None
 1.22A 5a6iA-1sxrA:
undetectable		 5a6iA-1sxrA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4n RIBONUCLEASE III

(Saccharomyces
cerevisiae) 		PF00035
(dsrm) 		4 LYS A 443
ALA A 446
LEU A 377
SER A 376
 None
 0.78A 5a6iA-1t4nA:
undetectable		 5a6iA-1t4nA:
18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		5 LEU A  17
ALA A 108
LEU A 110
SER A 117
VAL A 121
 None
 0.45A 5a6iA-1tfpA:
20.1		 5a6iA-1tfpA:
72.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		5 LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
 None
 0.82A 5a6iA-1tfpA:
20.1		 5a6iA-1tfpA:
72.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE

(Staphylococcus
aureus) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 LYS A   2
ALA A 170
SER A 315
VAL A 319
 None
 1.17A 5a6iA-1tvzA:
undetectable		 5a6iA-1tvzA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u71 DIHYDROFOLATE
REDUCTASE

(Homo sapiens) 		PF00186
(DHFR_1) 		4 LEU A  79
LEU A  89
SER A  90
VAL A 120
 None
None
None
SO4  A 188 (-4.5A)
 1.27A 5a6iA-1u71A:
undetectable		 5a6iA-1u71A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wfx PROBABLE RNA
2'-PHOSPHOTRANSFERAS
E

(Aeropyrum
pernix) 		PF01885
(PTS_2-RNA) 		4 ALA A 140
LEU A 138
SER A 181
VAL A 177
 None
 1.02A 5a6iA-1wfxA:
undetectable		 5a6iA-1wfxA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wx0 TRANSALDOLASE

(Thermus
thermophilus) 		PF00923
(TAL_FSA) 		4 LEU A   5
LEU A  22
SER A  23
VAL A 180
 None
 1.25A 5a6iA-1wx0A:
undetectable		 5a6iA-1wx0A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvy SFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		4 LYS A 163
LEU A 159
ALA A 306
LEU A 302
 None
 1.09A 5a6iA-1xvyA:
undetectable		 5a6iA-1xvyA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zch HYPOTHETICAL
OXIDOREDUCTASE YCND

(Bacillus
subtilis) 		PF00881
(Nitroreductase) 		4 LEU A 128
ALA A 124
LEU A 130
VAL A  34
 None
 1.11A 5a6iA-1zchA:
undetectable		 5a6iA-1zchA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2af5 ENGINEERED OUTER
SURFACE PROTEIN A
(OSPA) WITH THE
INSERTED TWO
BETA-HAIRPINS

(Borreliella
burgdorferi) 		PF00820
(Lipoprotein_1) 		4 LYS A 279
LEU A 281
LEU A 269
VAL A 273
 None
 0.93A 5a6iA-2af5A:
undetectable		 5a6iA-2af5A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2au3 DNA PRIMASE

(Aquifex
aeolicus) 		PF01807
(zf-CHC2)
PF08275
(Toprim_N)
PF13155
(Toprim_2) 		4 LEU A 229
ALA A 278
LEU A 280
VAL A 314
 None
 1.27A 5a6iA-2au3A:
undetectable		 5a6iA-2au3A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cq2 HYPOTHETICAL PROTEIN
LOC91801

(Homo sapiens) 		PF00076
(RRM_1) 		4 LEU A 117
ALA A  85
SER A  83
VAL A  71
 None
 1.23A 5a6iA-2cq2A:
undetectable		 5a6iA-2cq2A:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dre WATER-SOLUBLE
CHLOROPHYLL PROTEIN

(Lepidium
virginicum) 		PF00197
(Kunitz_legume) 		4 ALA A  37
LEU A 153
SER A 152
VAL A  35
 CLA  A1001 (-3.5A)
None
None
CLA  A1001 (-4.1A)
 1.03A 5a6iA-2dreA:
undetectable		 5a6iA-2dreA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejv L-THREONINE
3-DEHYDROGENASE

(Thermus
thermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 319
ALA A 122
LEU A   4
VAL A 125
 None
 1.28A 5a6iA-2ejvA:
undetectable		 5a6iA-2ejvA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fd5 TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		4 LEU A  73
LEU A  77
SER A  78
VAL A 179
 None
 0.78A 5a6iA-2fd5A:
undetectable		 5a6iA-2fd5A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3b PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		4 LEU A 180
LEU A  84
SER A  83
VAL A  94
 None
 1.22A 5a6iA-2g3bA:
undetectable		 5a6iA-2g3bA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN

(Homo sapiens) 		PF05971
(Methyltransf_10) 		4 LEU A 129
ALA A 132
LEU A 128
VAL A 121
 None
None
SAH  A 300 (-4.7A)
None
 1.06A 5a6iA-2h00A:
undetectable		 5a6iA-2h00A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		4 LEU A   6
LEU A  76
SER A  83
VAL A  87
 None
 0.98A 5a6iA-2o5vA:
undetectable		 5a6iA-2o5vA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ow4 CANAVALIA MARITIMA
LECTIN

(Canavalia rosea) 		PF00139
(Lectin_legB) 		4 LEU A 198
LEU A 107
SER A 108
VAL A  65
 None
 1.18A 5a6iA-2ow4A:
undetectable		 5a6iA-2ow4A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk0 SERINE/THREONINE
PROTEIN PHOSPHATASE
STP1

(Streptococcus
agalactiae) 		PF13672
(PP2C_2) 		4 LEU A 194
LEU A 198
SER A 199
VAL A 124
 None
 1.03A 5a6iA-2pk0A:
undetectable		 5a6iA-2pk0A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0l THIOREDOXIN
REDUCTASE

(Helicobacter
pylori) 		PF07992
(Pyr_redox_2) 		4 LEU A  74
ALA A  20
SER A  15
VAL A 304
 None
 1.20A 5a6iA-2q0lA:
undetectable		 5a6iA-2q0lA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q62 ARSH

(Sinorhizobium
meliloti) 		PF03358
(FMN_red) 		4 ALA A  54
LEU A  52
SER A  48
VAL A  70
 None
None
SO4  A2001 (-2.7A)
None
 1.26A 5a6iA-2q62A:
undetectable		 5a6iA-2q62A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmo DETHIOBIOTIN
SYNTHETASE

(Helicobacter
pylori) 		PF13500
(AAA_26) 		4 LEU A 168
ALA A 140
LEU A 136
VAL A 115
 None
 1.21A 5a6iA-2qmoA:
undetectable		 5a6iA-2qmoA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2u PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF00028
(Cadherin) 		4 LEU A 127
ALA A 143
SER A  32
VAL A 145
 None
 1.28A 5a6iA-2x2uA:
undetectable		 5a6iA-2x2uA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 LEU A 306
ALA A 538
LEU A 304
SER A 533
 None
 1.12A 5a6iA-2xydA:
undetectable		 5a6iA-2xydA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Bacillus
subtilis) 		PF01008
(IF-2B) 		4 LEU A  64
LEU A 107
SER A 110
VAL A 117
 None
 1.17A 5a6iA-2yrfA:
undetectable		 5a6iA-2yrfA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zm2 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Flavobacterium
sp.) 		PF00144
(Beta-lactamase) 		4 LEU A 243
LEU A 117
SER A 116
VAL A 300
 None
 1.02A 5a6iA-2zm2A:
undetectable		 5a6iA-2zm2A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 LEU A 213
ALA A 203
LEU A 201
VAL A 205
 None
 1.28A 5a6iA-2ztgA:
undetectable		 5a6iA-2ztgA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ail 303AA LONG
HYPOTHETICAL
ESTERASE

(Sulfurisphaera
tokodaii) 		PF07859
(Abhydrolase_3) 		4 LEU A 175
ALA A 235
SER A 265
VAL A 261
 None
 0.83A 5a6iA-3ailA:
undetectable		 5a6iA-3ailA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 LYS A 528
LEU A 526
ALA A 482
VAL A 558
 None
 0.71A 5a6iA-3aqpA:
undetectable		 5a6iA-3aqpA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Rhodospirillum
rubrum) 		PF00440
(TetR_N) 		4 LEU A 174
ALA A 106
LEU A 102
VAL A  68
 None
 0.99A 5a6iA-3cwrA:
undetectable		 5a6iA-3cwrA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqa GLUCOAMYLASE

(Aspergillus
niger) 		PF00723
(Glyco_hydro_15) 		4 LYS A 402
LEU A 356
ALA A 405
VAL A 409
 None
 1.06A 5a6iA-3eqaA:
undetectable		 5a6iA-3eqaA:
16.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		5 LYS A  15
LEU A  17
ALA A 108
LEU A 110
VAL A 121
 IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
None
 0.46A 5a6iA-3fc8A:
23.5		 5a6iA-3fc8A:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
LEU A 110
SER A 117
 IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
 0.77A 5a6iA-3fc8A:
23.5		 5a6iA-3fc8A:
99.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2

(Mus musculus) 		PF04916
(Phospholip_B) 		4 LEU A  78
ALA A 122
LEU A 205
SER A 200
 IOD  A 609 (-4.1A)
None
None
None
 1.25A 5a6iA-3fgwA:
undetectable		 5a6iA-3fgwA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gve YFKN PROTEIN

(Bacillus
subtilis) 		PF00149
(Metallophos) 		4 LEU A 291
ALA A 301
LEU A 289
SER A 303
 None
 1.26A 5a6iA-3gveA:
undetectable		 5a6iA-3gveA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hum PENICILLIN-BINDING
PROTEIN 4

(Staphylococcus
aureus) 		PF00768
(Peptidase_S11)
PF09211
(DUF1958) 		4 LEU A 112
ALA A 142
LEU A 115
SER A 116
 None
None
None
CEW  A 501 (-3.1A)
 1.06A 5a6iA-3humA:
undetectable		 5a6iA-3humA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7

(Streptomyces
avermitilis) 		PF03259
(Robl_LC7) 		4 ALA A  30
LEU A  32
SER A  41
VAL A  21
 None
 1.25A 5a6iA-3kyeA:
undetectable		 5a6iA-3kyeA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		4 LEU A 310
LEU A 290
SER A 293
VAL A 237
 None
 1.04A 5a6iA-3nowA:
undetectable		 5a6iA-3nowA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oit OS07G0271500 PROTEIN

(Oryza sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ALA A 392
LEU A 394
SER A 250
VAL A 390
 None
 0.92A 5a6iA-3oitA:
undetectable		 5a6iA-3oitA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)

(Mycobacterium
tuberculosis) 		PF03602
(Cons_hypoth95) 		4 LEU A  89
LEU A  91
SER A  92
VAL A  47
 None
 0.94A 5a6iA-3p9nA:
undetectable		 5a6iA-3p9nA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf0 IMELYSIN-LIKE
PROTEIN

(Psychrobacter
arcticus) 		PF09375
(Peptidase_M75) 		4 LEU A 275
ALA A 281
LEU A 277
SER A 278
 None
 1.10A 5a6iA-3pf0A:
undetectable		 5a6iA-3pf0A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qac 11S GLOBULIN SEED
STORAGE PROTEIN

(Amaranthus
hypochondriacus) 		PF00190
(Cupin_1) 		4 LEU A 318
ALA A 325
LEU A 323
VAL A 398
 None
 1.13A 5a6iA-3qacA:
undetectable		 5a6iA-3qacA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rb5 NA/CA EXCHANGE
PROTEIN

(Drosophila
melanogaster) 		PF03160
(Calx-beta) 		4 LYS A 656
LEU A 653
ALA A 655
LEU A 647
 None
 1.27A 5a6iA-3rb5A:
2.7		 5a6iA-3rb5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdi PROTEASOME COMPONENT
PRE5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		4 LEU E 176
ALA E 164
LEU E  40
VAL E  36
 None
 1.17A 5a6iA-3sdiE:
undetectable		 5a6iA-3sdiE:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si9 DIHYDRODIPICOLINATE
SYNTHASE

(Bartonella
henselae) 		PF00701
(DHDPS) 		4 LEU A 264
ALA A 260
LEU A 266
VAL A 248
 None
 0.76A 5a6iA-3si9A:
undetectable		 5a6iA-3si9A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1

(Arabidopsis
thaliana) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH) 		4 ALA A 161
LEU A 207
SER A 208
VAL A 157
 None
None
GOL  A 302 (-4.8A)
None
 1.29A 5a6iA-3twkA:
undetectable		 5a6iA-3twkA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE

(Acetobacter
aceti) 		PF02515
(CoA_transf_3) 		4 LEU A 226
ALA A 222
LEU A 186
VAL A 217
 None
 1.14A 5a6iA-3ubmA:
undetectable		 5a6iA-3ubmA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk1 TRANSKETOLASE

(Burkholderia
thailandensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU A 513
ALA A 473
LEU A 470
VAL A 447
 None
 1.15A 5a6iA-3uk1A:
undetectable		 5a6iA-3uk1A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxj NADPH-DEPENDENT
7-CYANO-7-DEAZAGUANI
NE REDUCTASE

(Vibrio cholerae) 		PF14489
(QueF)
PF14819
(QueF_N) 		4 LYS A  96
LEU A 100
LEU A  35
SER A  34
 NAP  A 291 (-3.1A)
None
None
None
 1.06A 5a6iA-3uxjA:
undetectable		 5a6iA-3uxjA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvi TYPE-2 RESTRICTION
ENZYME HINDIII

(Haemophilus
influenzae) 		PF09518
(RE_HindIII) 		4 LEU A  78
ALA A  74
LEU A  80
SER A  82
 None
 1.05A 5a6iA-3wviA:
undetectable		 5a6iA-3wviA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zre THIOL PEROXIDASE

(Yersinia
pseudotuberculosis) 		PF08534
(Redoxin) 		4 LEU A 127
ALA A 132
LEU A 130
SER A  85
 None
 1.18A 5a6iA-3zreA:
undetectable		 5a6iA-3zreA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkm PYRIDOXAL PHOSPHATE
PHOSPHATASE,
PHOSPHOGLYCOLATE
PHOSPHATASE,
PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 ALA A  92
LEU A  90
SER A  87
VAL A 156
 None
 1.04A 5a6iA-4bkmA:
undetectable		 5a6iA-4bkmA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Toxoplasma
gondii) 		PF00274
(Glycolytic) 		4 LEU A 294
ALA A 298
LEU A  86
VAL A 258
 None
 1.29A 5a6iA-4d2jA:
undetectable		 5a6iA-4d2jA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493

(Thermus
thermophilus) 		PF02475
(Met_10) 		4 LEU A 259
ALA A 255
LEU A 261
VAL A 225
 None
 1.03A 5a6iA-4dmgA:
undetectable		 5a6iA-4dmgA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		4 LEU A 453
ALA A 451
LEU A 502
VAL A 347
 None
ANP  A 701 (-4.1A)
None
None
 1.28A 5a6iA-4fl3A:
undetectable		 5a6iA-4fl3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hes BETA-LACTAMASE CLASS
A-LIKE PROTEIN

(Veillonella
parvula) 		PF13354
(Beta-lactamase2) 		4 LEU A  95
LEU A  83
SER A  84
VAL A 128
 None
 1.23A 5a6iA-4hesA:
undetectable		 5a6iA-4hesA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF13416
(SBP_bac_8) 		4 LEU A1135
LEU A1157
SER A1186
VAL A1131
 None
 1.00A 5a6iA-4kegA:
undetectable		 5a6iA-4kegA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE

(Lactobacillus
casei) 		PF01408
(GFO_IDH_MocA) 		4 LEU A 213
LEU A 227
SER A 154
VAL A 150
 None
None
GOL  A 402 (-2.8A)
None
 0.97A 5a6iA-4mioA:
undetectable		 5a6iA-4mioA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5i CHEMOKINE BINDING
PROTEIN

(Orf virus) 		PF02250
(Orthopox_35kD) 		4 LEU A 208
ALA A 145
SER A  82
VAL A  86
 None
None
NAG  A 301 ( 4.9A)
None
 0.85A 5a6iA-4p5iA:
undetectable		 5a6iA-4p5iA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR

(Gallus gallus) 		PF13516
(LRR_6) 		4 LEU A 224
LEU A 218
SER A 215
VAL A 182
 None
 1.21A 5a6iA-4perA:
undetectable		 5a6iA-4perA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4raj HEME OXYGENASE

(Chlamydomonas
reinhardtii) 		PF01126
(Heme_oxygenase) 		4 LEU A  90
ALA A 149
LEU A 184
SER A 180
 None
 1.10A 5a6iA-4rajA:
undetectable		 5a6iA-4rajA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 LYS A1844
LEU A1851
SER A1852
VAL A1899
 None
 1.24A 5a6iA-4rh7A:
undetectable		 5a6iA-4rh7A:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE

(Plasmodium
vivax) 		PF00082
(Peptidase_S8) 		4 LEU A 480
ALA A 499
SER A 593
VAL A 497
 None
 1.09A 5a6iA-4tr2A:
undetectable		 5a6iA-4tr2A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 LEU A 170
ALA A 227
SER A 225
VAL A 293
 None
 1.19A 5a6iA-4um8A:
undetectable		 5a6iA-4um8A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 4

(Drosophila
melanogaster) 		PF13191
(AAA_16)
PF14629
(ORC4_C) 		4 LEU D 340
LEU D 343
SER D 344
VAL D 450
 None
 1.17A 5a6iA-4xgcD:
undetectable		 5a6iA-4xgcD:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE

(Aspergillus
flavus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 LEU A 282
LEU A 286
SER A 287
VAL A 535
 None
 1.23A 5a6iA-4ynuA:
undetectable		 5a6iA-4ynuA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z6k ALCOHOL
DEHYDROGENASE

(Moraxella sp.
TAE123) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 257
LEU A 248
SER A 249
VAL A 194
 None
 1.21A 5a6iA-4z6kA:
undetectable		 5a6iA-4z6kA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zda ISOCITRATE
DEHYDROGENASE (NADP)
ICD2

(Mycolicibacterium
smegmatis) 		PF03971
(IDH) 		4 LEU A 643
LEU A 666
SER A 667
VAL A 702
 None
 1.12A 5a6iA-4zdaA:
undetectable		 5a6iA-4zdaA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 LEU A 763
ALA A 749
LEU A 745
SER A 779
 None
 1.25A 5a6iA-5dllA:
undetectable		 5a6iA-5dllA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzu ASPARTIC PROTEASE
INHIBITOR 11

(Solanum
tuberosum) 		PF00197
(Kunitz_legume) 		4 LYS A 128
LEU A  80
LEU A  71
SER A  72
 None
 1.20A 5a6iA-5dzuA:
undetectable		 5a6iA-5dzuA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		4 ALA A 534
LEU A 532
SER A 529
VAL A 462
 None
 1.22A 5a6iA-5e31A:
undetectable		 5a6iA-5e31A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 LYS A 827
ALA A 824
LEU A 610
VAL A 820
 None
 1.23A 5a6iA-5epgA:
undetectable		 5a6iA-5epgA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2v IMPORTIN SUBUNIT
BETA-3

(Saccharomyces
cerevisiae) 		PF13513
(HEAT_EZ) 		4 LEU A 372
LEU A 391
SER A 392
VAL A 424
 None
 1.28A 5a6iA-5h2vA:
undetectable		 5a6iA-5h2vA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h68 CHROMOSOME PARTITION
PROTEIN SMC

(Geobacillus
stearothermophilus) 		PF02463
(SMC_N) 		4 LEU A1086
LEU A1089
SER A1090
VAL A 146
 None
 0.95A 5a6iA-5h68A:
undetectable		 5a6iA-5h68A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjx SQUAMOUS CELL
CARCINOMA ANTIGEN
RECOGNIZED BY
T-CELLS 3

(Homo sapiens) 		no annotation 4 LEU A 227
LEU A 214
SER A 215
VAL A 177
 None
None
None
UNX  A 412 ( 4.5A)
 1.12A 5a6iA-5jjxA:
undetectable		 5a6iA-5jjxA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		4 LEU A 278
ALA A 281
LEU A 279
SER A 307
 None
 1.26A 5a6iA-5kznA:
undetectable		 5a6iA-5kznA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mw7 PROTEIN JAGGED-2

(Homo sapiens) 		PF00008
(EGF)
PF01414
(DSL)
PF07657
(MNNL) 		4 LYS A 179
LEU A 181
LEU A 192
VAL A 196
 None
 0.84A 5a6iA-5mw7A:
3.0		 5a6iA-5mw7A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njf METALLOPROTEASE TLDD

(Escherichia
coli) 		PF01523
(PmbA_TldD) 		4 LEU A 185
ALA A 157
LEU A 159
VAL A 155
 None
 1.28A 5a6iA-5njfA:
undetectable		 5a6iA-5njfA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		4 LEU A   3
ALA A   8
LEU A   6
VAL A  80
 None
 1.08A 5a6iA-5t2uA:
undetectable		 5a6iA-5t2uA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		4 LEU A 335
LEU A 363
SER A 364
VAL A 368
 None
 1.04A 5a6iA-5u0lA:
undetectable		 5a6iA-5u0lA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w81 CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Danio rerio) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		4 LEU A 601
ALA A 572
LEU A 570
SER A 490
 None
 0.81A 5a6iA-5w81A:
undetectable		 5a6iA-5w81A:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yiv CELL CYCLE
REGULATORY PROTEIN
GCRA

(Caulobacter
vibrioides) 		no annotation 4 LEU A  14
LEU A  19
SER A  20
VAL A  31
 None
 0.99A 5a6iA-5yivA:
undetectable		 5a6iA-5yivA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6amw TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1) 		4 LEU A 214
LEU A 141
SER A 140
VAL A 151
 None
 1.06A 5a6iA-6amwA:
undetectable		 5a6iA-6amwA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b92 U6 SMALL NUCLEAR RNA
(ADENINE-(43)-N(6))-
METHYLTRANSFERASE

(Homo sapiens) 		no annotation 4 LEU A 166
ALA A 169
LEU A 165
VAL A 158
 None
None
SAH  A 305 ( 4.6A)
None
 0.98A 5a6iA-6b92A:
undetectable		 5a6iA-6b92A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger) 		no annotation 4 LYS A 402
LEU A 356
ALA A 405
VAL A 409
 None
 1.10A 5a6iA-6frvA:
undetectable		 5a6iA-6frvA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g1k TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY C
MEMBER 4A

(Danio rerio) 		no annotation 4 ALA A 210
LEU A 208
SER A 205
VAL A 717
 None
 0.83A 5a6iA-6g1kA:
undetectable		 5a6iA-6g1kA:
22.66