SIMILAR PATTERNS OF AMINO ACIDS FOR 5A5Z_C_WJZC304_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ddk IMP-1 METALLO
BETA-LACTAMASE


(Pseudomonas
aeruginosa)
PF00753
(Lactamase_B)
6 HIS A 139
CYH A 158
LYS A 161
GLY A 166
ASN A 167
HIS A 197
ZN  A 500 (-3.3A)
ZN  A 501 ( 2.4A)
ZN  A 501 ( 4.5A)
None
ACY  A 510 (-4.4A)
ZN  A 501 ( 3.4A)
0.58A 5a5zC-1ddkA:
30.9
5a5zC-1ddkA:
33.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgf CATALASE

(Homo sapiens)
PF00199
(Catalase)
PF06628
(Catalase-rel)
4 MET A 212
HIS A  75
GLY A 147
ASN A 148
None
HEM  A3000 (-3.4A)
HEM  A3000 (-3.8A)
HEM  A3000 (-3.4A)
1.37A 5a5zC-1dgfA:
undetectable
5a5zC-1dgfA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eak 72 KDA TYPE IV
COLLAGENASE


(Homo sapiens)
PF00040
(fn2)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1)
4 HIS A 413
GLY A 103
ASN A 104
HIS A 403
ZN  A 997 (-3.5A)
None
None
ZN  A 997 (-3.5A)
1.38A 5a5zC-1eakA:
undetectable
5a5zC-1eakA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hbz CATALASE

(Micrococcus
luteus)
PF00199
(Catalase)
PF06628
(Catalase-rel)
4 MET A 197
HIS A  61
GLY A 132
ASN A 133
None
HEM  A 504 (-3.3A)
HEM  A 504 (-3.8A)
HEM  A 504 (-3.2A)
1.31A 5a5zC-1hbzA:
undetectable
5a5zC-1hbzA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlk BETA-LACTAMASE, TYPE
II


(Bacteroides
fragilis)
no annotation 5 HIS A 162
CYH A 181
GLY A 192
ASN A 193
HIS A 223
ZN  A1001 (-3.3A)
ZN  A1002 ( 2.1A)
113  A2002 ( 3.8A)
113  A2002 (-4.1A)
113  A2002 ( 3.6A)
0.50A 5a5zC-1hlkA:
32.2
5a5zC-1hlkA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlk BETA-LACTAMASE, TYPE
II


(Bacteroides
fragilis)
no annotation 4 HIS A 162
LYS A 184
GLY A 192
ASN A 193
ZN  A1001 (-3.3A)
113  A2002 (-3.6A)
113  A2002 ( 3.8A)
113  A2002 (-4.1A)
0.82A 5a5zC-1hlkA:
32.2
5a5zC-1hlkA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikp EXOTOXIN A

(Pseudomonas
aeruginosa)
PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target)
4 HIS A 107
LYS A 185
GLY A  39
ASN A  38
None
0.87A 5a5zC-1ikpA:
undetectable
5a5zC-1ikpA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq0 METHIONINE
AMINOPEPTIDASE 2


(Homo sapiens)
PF00557
(Peptidase_M24)
4 MET A 184
HIS A 460
GLY A 475
HIS A 176
TBU  A 501 ( 4.1A)
None
None
None
1.30A 5a5zC-1kq0A:
undetectable
5a5zC-1kq0A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llu ALCOHOL
DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 MET A 329
HIS A  67
CYH A 154
GLY A  42
NAD  A1250 ( 4.4A)
ZN  A 343 ( 3.3A)
ZN  A 343 ( 2.4A)
None
1.14A 5a5zC-1lluA:
undetectable
5a5zC-1lluA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2x CLASS B
CARBAPENEMASE BLAB-1


(Elizabethkingia
meningoseptica)
PF00753
(Lactamase_B)
5 HIS A 196
CYH A 221
LYS A 224
GLY A 232
HIS A 263
ZN  A 901 ( 3.2A)
ZN  A 902 (-2.3A)
None
None
ZN  A 902 (-3.2A)
0.70A 5a5zC-1m2xA:
29.3
5a5zC-1m2xA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7s CATALASE

(Pseudomonas
syringae)
PF00199
(Catalase)
PF06628
(Catalase-rel)
4 MET A 214
HIS A  78
GLY A 149
ASN A 150
None
HEM  A 600 (-3.3A)
HEM  A 600 (-4.0A)
HEM  A 600 (-3.4A)
1.31A 5a5zC-1m7sA:
undetectable
5a5zC-1m7sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)


(Escherichia
coli)
PF00199
(Catalase)
PF06628
(Catalase-rel)
4 MET A 269
HIS A 128
GLY A 200
ASN A 201
None
HEM  A 754 ( 3.3A)
HEM  A 754 (-3.8A)
HEM  A 754 ( 3.4A)
1.32A 5a5zC-1qf7A:
undetectable
5a5zC-1qf7A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si8 CATALASE

(Enterococcus
faecalis)
PF00199
(Catalase)
PF06628
(Catalase-rel)
4 MET A 191
HIS A  54
GLY A 126
ASN A 127
None
HEM  A 501 (-3.5A)
HEM  A 501 (-3.8A)
HEM  A 501 (-3.2A)
1.39A 5a5zC-1si8A:
undetectable
5a5zC-1si8A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2


(Carboxydothermus
hydrogenoformans)
PF03063
(Prismane)
4 HIS A 561
CYH A 333
GLY A  92
HIS A 261
NFS  A 639 (-4.5A)
NFS  A 639 (-2.2A)
None
NFS  A 639 (-3.3A)
1.14A 5a5zC-1su7A:
undetectable
5a5zC-1su7A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa)
PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel)
4 MET A 233
HIS A  92
GLY A 164
ASN A 165
None
HEM  A1883 ( 3.5A)
HDD  A1880 ( 3.9A)
HDD  A1880 ( 3.1A)
1.34A 5a5zC-1sy7A:
undetectable
5a5zC-1sy7A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wew DNA-BINDING FAMILY
PROTEIN


(Arabidopsis
thaliana)
PF00628
(PHD)
4 HIS A  43
CYH A  46
GLY A  22
ASN A  23
ZN  A 201 (-3.4A)
ZN  A 201 (-2.3A)
None
None
1.12A 5a5zC-1wewA:
undetectable
5a5zC-1wewA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2b PROLINE
IMINOPEPTIDASE


(Serratia
marcescens)
PF00561
(Abhydrolase_1)
4 HIS A 296
CYH A 271
GLY A 295
HIS A 264
STX  A 401 (-4.5A)
STX  A 401 ( 4.9A)
None
None
1.38A 5a5zC-1x2bA:
undetectable
5a5zC-1x2bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adu METHIONINE
AMINOPEPTIDASE 2


(Homo sapiens)
PF00557
(Peptidase_M24)
4 MET A 184
HIS A 460
GLY A 475
HIS A 176
None
1.25A 5a5zC-2aduA:
undetectable
5a5zC-2aduA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN


(Azotobacter
vinelandii)
PF00148
(Oxidored_nitro)
PF11844
(DUF3364)
4 MET B 213
GLY B 219
ASN B 286
HIS B 311
None
1.23A 5a5zC-2afhB:
undetectable
5a5zC-2afhB:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5


(Homo sapiens)
PF00149
(Metallophos)
4 HIS X  90
GLY X  88
ASN X  89
HIS X 219
None
None
None
FE2  X1306 (-3.2A)
0.98A 5a5zC-2bq8X:
undetectable
5a5zC-2bq8X:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ess ACYL-ACP
THIOESTERASE


(Bacteroides
thetaiotaomicron)
PF01643
(Acyl-ACP_TE)
4 HIS A  33
GLY A  28
ASN A  32
HIS A  18
CL  A 251 (-4.3A)
None
None
CL  A 251 (-3.9A)
1.16A 5a5zC-2essA:
undetectable
5a5zC-2essA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE


(Enterococcus
faecalis)
PF02558
(ApbA)
PF08546
(ApbA_C)
4 MET A 262
GLY A 280
ASN A 279
HIS A 304
None
1.33A 5a5zC-2ew2A:
undetectable
5a5zC-2ew2A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhx SPM-1

(Pseudomonas
aeruginosa)
PF00753
(Lactamase_B)
4 HIS B 196
LYS B 224
GLY B 232
HIS B 263
ZN  B 317 ( 3.2A)
AZI  B 402 (-2.9A)
AZI  B 402 ( 3.7A)
CSO  B 221 (-3.5A)
0.62A 5a5zC-2fhxB:
28.8
5a5zC-2fhxB:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqf CATALASE

(Helicobacter
pylori)
PF00199
(Catalase)
PF06628
(Catalase-rel)
4 MET A 193
HIS A  56
GLY A 128
ASN A 129
None
HEM  A 550 ( 3.4A)
HEM  A 550 (-3.9A)
HEM  A 550 (-3.2A)
1.39A 5a5zC-2iqfA:
undetectable
5a5zC-2iqfA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isa CATALASE

(Aliivibrio
salmonicida)
PF00199
(Catalase)
PF06628
(Catalase-rel)
4 MET A 191
HIS A  54
GLY A 126
ASN A 127
None
HEM  A 486 (-3.4A)
HEM  A 486 (-4.1A)
HEM  A 486 (-3.4A)
1.36A 5a5zC-2isaA:
undetectable
5a5zC-2isaA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j2m CATALASE

(Exiguobacterium
oxidotolerans)
PF00199
(Catalase)
PF06628
(Catalase-rel)
4 MET A 193
HIS A  56
GLY A 128
ASN A 129
None
HEM  A 501 (-3.3A)
HEM  A 501 (-3.7A)
HEM  A 501 (-3.6A)
1.39A 5a5zC-2j2mA:
undetectable
5a5zC-2j2mA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kak EC PROTEIN I/II

(Triticum
aestivum)
PF02068
(Metallothio_PEC)
4 CYH A  47
GLY A  43
ASN A  45
HIS A  41
ZN  A 130 ( 2.3A)
None
None
ZN  A 130 (-3.1A)
1.33A 5a5zC-2kakA:
undetectable
5a5zC-2kakA:
9.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nyp BETA-LACTAMASE II

(Bacillus cereus)
PF00753
(Lactamase_B)
5 HIS A 149
LYS A 171
GLY A 179
ASN A 180
HIS A 210
ZN  A 301 (-3.2A)
None
None
None
ZN  A 302 (-4.1A)
0.53A 5a5zC-2nypA:
30.8
5a5zC-2nypA:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nyp BETA-LACTAMASE II

(Bacillus cereus)
PF00753
(Lactamase_B)
4 HIS A 210
LYS A 171
GLY A 167
HIS A 149
ZN  A 302 (-4.1A)
None
None
ZN  A 301 (-3.2A)
1.17A 5a5zC-2nypA:
30.8
5a5zC-2nypA:
32.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE


(Lactococcus
lactis)
PF00232
(Glyco_hydro_1)
4 HIS A 196
GLY A 213
ASN A 291
HIS A 216
None
1.16A 5a5zC-2pbgA:
undetectable
5a5zC-2pbgA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9u A-TYPE FLAVOPROTEIN

(Giardia
intestinalis)
no annotation 4 HIS A 230
GLY A 172
ASN A 170
HIS A 152
FEO  A 701 ( 3.3A)
None
None
FEO  A 701 ( 3.4A)
1.23A 5a5zC-2q9uA:
17.3
5a5zC-2q9uA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uu7 GLUTAMINE SYNTHETASE

(Canis lupus)
PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N)
4 HIS A 304
LYS A 241
GLY A 245
ASN A 246
None
0.99A 5a5zC-2uu7A:
undetectable
5a5zC-2uu7A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2


(Bacillus
subtilis)
PF00884
(Sulfatase)
4 HIS A 343
GLY A 381
ASN A 345
HIS A 412
None
None
None
TPO  A 297 ( 4.0A)
1.08A 5a5zC-2w8dA:
undetectable
5a5zC-2w8dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynt GIM-1 PROTEIN

(Pseudomonas
aeruginosa)
PF00753
(Lactamase_B)
4 HIS B 196
CYH B 221
GLY B 232
HIS B 263
ZN  B1297 (-3.2A)
ZN  B1298 (-2.2A)
None
ZN  B1298 (-3.2A)
0.35A 5a5zC-2yntB:
32.1
5a5zC-2yntB:
29.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
4 HIS A 398
CYH A 457
GLY A 365
ASN A 364
CU  A 704 (-3.5A)
CU  A 704 (-2.3A)
None
None
1.39A 5a5zC-3abgA:
undetectable
5a5zC-3abgA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhn NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E


(Bacteroides
thetaiotaomicron)
PF13460
(NAD_binding_10)
4 HIS A 191
GLY A 188
ASN A 189
HIS A 222
None
1.39A 5a5zC-3dhnA:
undetectable
5a5zC-3dhnA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG


(Sulfolobus
solfataricus)
PF01890
(CbiG_C)
PF11760
(CbiG_N)
4 LYS A 136
GLY A 109
ASN A 111
HIS A 107
None
None
SO4  A   2 (-3.9A)
None
1.24A 5a5zC-3eeqA:
undetectable
5a5zC-3eeqA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]


(Escherichia
coli)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
4 MET A 438
HIS A 405
GLY A  84
ASN A  83
TDP  A 611 ( 3.7A)
None
None
None
1.16A 5a5zC-3eyaA:
undetectable
5a5zC-3eyaA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fai BETA-LACTAMASE

(Aeromonas
hydrophila)
PF00753
(Lactamase_B)
5 HIS A 196
CYH A 221
LYS A 224
GLY A 232
HIS A 263
ZN  A   2 ( 3.2A)
ZN  A   1 ( 2.2A)
SO4  A 311 ( 4.7A)
GOL  A 320 (-3.5A)
ZN  A   1 ( 3.2A)
0.75A 5a5zC-3faiA:
27.5
5a5zC-3faiA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fai BETA-LACTAMASE

(Aeromonas
hydrophila)
PF00753
(Lactamase_B)
4 HIS A 196
LYS A 224
GLY A 232
ASN A 233
ZN  A   2 ( 3.2A)
SO4  A 311 ( 4.7A)
GOL  A 320 (-3.5A)
None
0.80A 5a5zC-3faiA:
27.5
5a5zC-3faiA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6e CARBOHYDRATE KINASE,
FGGY


(Novosphingobium
aromaticivorans)
PF00370
(FGGY_N)
4 HIS A 172
GLY A 170
ASN A 283
HIS A 230
None
1.31A 5a5zC-3h6eA:
undetectable
5a5zC-3h6eA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE


(Medicago
truncatula)
PF00201
(UDPGT)
4 MET A 368
HIS A 150
GLY A 378
ASN A 380
None
1.00A 5a5zC-3hbjA:
undetectable
5a5zC-3hbjA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF10


(Schizosaccharomyces
pombe)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2)
4 MET B 597
LYS B 154
GLY B 219
ASN B 250
None
GDP  B1000 ( 3.5A)
GDP  B1000 ( 4.7A)
None
1.29A 5a5zC-3jb9B:
undetectable
5a5zC-3jb9B:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7d GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE


(Escherichia
coli)
PF03710
(GlnE)
PF08335
(GlnD_UR_UTase)
4 HIS A 674
CYH A 710
GLY A 682
HIS A 708
None
1.26A 5a5zC-3k7dA:
undetectable
5a5zC-3k7dA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kie CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A)
PF00740
(Parvo_coat)
4 HIS A 229
LYS A 314
GLY A 226
ASN A 227
None
1.21A 5a5zC-3kieA:
undetectable
5a5zC-3kieA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzw CYTOSOL
AMINOPEPTIDASE


(Staphylococcus
aureus)
PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N)
4 HIS A 431
LYS A 437
GLY A 434
ASN A 433
None
1.34A 5a5zC-3kzwA:
undetectable
5a5zC-3kzwA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6n METALLO-BETA-LACTAMA
SE


(Chryseobacterium
indologenes)
PF00753
(Lactamase_B)
5 HIS A 159
CYH A 178
LYS A 181
GLY A 189
HIS A 220
ZN  A 301 (-3.2A)
ZN  A 302 (-2.0A)
None
None
ZN  A 302 (-3.6A)
0.88A 5a5zC-3l6nA:
28.1
5a5zC-3l6nA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE


(Streptococcus
mutans)
PF01048
(PNP_UDP_1)
4 MET A  90
HIS A 130
GLY A 184
ASN A 132
None
1.20A 5a5zC-3la8A:
undetectable
5a5zC-3la8A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3meq ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING


(Brucella suis)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 MET A 329
HIS A  65
CYH A 152
GLY A  40
NAI  A 601 ( 4.5A)
ZN  A 401 ( 3.2A)
ZN  A 401 (-2.2A)
None
1.05A 5a5zC-3meqA:
undetectable
5a5zC-3meqA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orw PHOSPHOTRIESTERASE

(Geobacillus
kaustophilus)
PF02126
(PTE)
4 HIS A 290
GLY A 232
ASN A 288
HIS A 265
None
1.37A 5a5zC-3orwA:
undetectable
5a5zC-3orwA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3our PHOSPHOTRANSFERASE
SYSTEM IIA COMPONENT


(Vibrio
vulnificus)
PF00358
(PTS_EIIA_1)
4 MET B  60
GLY B 101
ASN B  75
HIS B  76
None
1.29A 5a5zC-3ourB:
undetectable
5a5zC-3ourB:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6v BETA-LACTAMASE

(Serratia
fonticola)
PF00753
(Lactamase_B)
6 HIS A 196
CYH A 221
LYS A 224
GLY A 232
ASN A 233
HIS A 263
GOL  A   1 (-3.5A)
ZN  A   2 ( 2.2A)
GOL  A   1 ( 4.6A)
None
GOL  A   1 (-3.4A)
ZN  A   2 ( 3.3A)
0.60A 5a5zC-3q6vA:
27.2
5a5zC-3q6vA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ra2 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A)
PF00740
(Parvo_coat)
4 HIS A 230
LYS A 317
GLY A 227
ASN A 228
None
1.29A 5a5zC-3ra2A:
undetectable
5a5zC-3ra2A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8l ADENINE DEAMINASE 2

(Agrobacterium
fabrum)
PF01979
(Amidohydro_1)
PF13382
(Adenine_deam_C)
4 HIS A 480
GLY A 125
ASN A 126
HIS A 122
None
None
None
UNX  A 607 ( 3.5A)
1.38A 5a5zC-3t8lA:
undetectable
5a5zC-3t8lA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8l ADENINE DEAMINASE 2

(Agrobacterium
fabrum)
PF01979
(Amidohydro_1)
PF13382
(Adenine_deam_C)
4 MET A 189
HIS A 480
GLY A 125
ASN A 126
None
1.31A 5a5zC-3t8lA:
undetectable
5a5zC-3t8lA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp9 BETA-LACTAMASE AND
RHODANESE DOMAIN
PROTEIN


(Alicyclobacillus
acidocaldarius)
PF00581
(Rhodanese)
PF00753
(Lactamase_B)
4 HIS A 196
CYH A 202
GLY A 145
HIS A 120
None
ZN  A 472 (-3.1A)
None
ZN  A 472 (-3.4A)
0.86A 5a5zC-3tp9A:
3.1
5a5zC-3tp9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfj 2-DEHYDROPANTOATE
2-REDUCTASE


(Enterococcus
faecium)
PF02558
(ApbA)
PF08546
(ApbA_C)
4 MET A 261
GLY A 279
ASN A 278
HIS A 303
None
1.27A 5a5zC-3wfjA:
undetectable
5a5zC-3wfjA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cab CATALASE

(Deinococcus
radiodurans)
PF00199
(Catalase)
PF06628
(Catalase-rel)
4 MET A 223
HIS A  81
GLY A 158
ASN A 159
None
HEM  A 537 (-3.4A)
HEM  A 537 (-4.0A)
HEM  A 537 (-3.5A)
1.29A 5a5zC-4cabA:
undetectable
5a5zC-4cabA:
18.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4d1t METALLO-B-LACTAMASE

(Pseudomonas
aeruginosa)
PF00753
(Lactamase_B)
5 HIS A 196
CYH A 221
GLY A 232
ASN A 233
HIS A 263
ZN  A1292 (-3.2A)
ZN  A1293 (-2.3A)
None
None
ZN  A1293 (-3.3A)
0.73A 5a5zC-4d1tA:
33.4
5a5zC-4d1tA:
32.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eex ALCOHOL
DEHYDROGENASE 1


(Lactococcus
lactis)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 MET A 325
HIS A  60
CYH A 147
GLY A  37
None
ZN  A 402 (-3.2A)
ZN  A 402 (-2.3A)
None
1.08A 5a5zC-4eexA:
2.2
5a5zC-4eexA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewg BETA-KETOACYL
SYNTHASE


(Paraburkholderia
phymatum)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
4 CYH A 340
LYS A 330
GLY A 302
HIS A 335
None
1.03A 5a5zC-4ewgA:
undetectable
5a5zC-4ewgA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkv ALCOHOL
DEHYDROGENASE,
PROPANOL-PREFERRING


(Escherichia
coli)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 MET A 321
HIS A  58
CYH A 145
GLY A  35
NAD  A 401 (-4.3A)
ZN  A 402 (-3.3A)
ZN  A 402 ( 2.3A)
None
1.07A 5a5zC-4gkvA:
undetectable
5a5zC-4gkvA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN


(Mycobacterium
tuberculosis)
PF02126
(PTE)
4 HIS A 285
GLY A 233
ASN A 283
HIS A 263
None
1.39A 5a5zC-4if2A:
undetectable
5a5zC-4if2A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR


(Homo sapiens)
PF00415
(RCC1)
4 CYH C 302
GLY C 320
ASN C 305
HIS C 254
None
1.31A 5a5zC-4jhpC:
undetectable
5a5zC-4jhpC:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR


(Homo sapiens)
PF00415
(RCC1)
4 HIS C  98
GLY C 112
ASN C  97
HIS C  46
None
1.30A 5a5zC-4jhpC:
undetectable
5a5zC-4jhpC:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Vibrio cholerae)
no annotation 4 CYH D 164
GLY D 407
ASN D 406
HIS D 304
None
1.19A 5a5zC-4jrmD:
undetectable
5a5zC-4jrmD:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE


(Porphyromonas
gingivalis)
PF01048
(PNP_UDP_1)
4 MET A 106
HIS A 148
GLY A 201
ASN A 150
None
1.19A 5a5zC-4ns1A:
undetectable
5a5zC-4ns1A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opu CONSERVED ARCHAEAL
PROTEIN


(Sulfolobus
acidocaldarius)
PF01266
(DAO)
4 HIS A 297
GLY A 300
ASN A 294
HIS A  55
GRG  A 502 ( 4.1A)
FDA  A 501 (-3.2A)
GRG  A 503 (-4.6A)
GRG  A 503 (-3.4A)
1.32A 5a5zC-4opuA:
undetectable
5a5zC-4opuA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Verminephrobacter
eiseniae)
PF03480
(DctP)
4 MET A 181
HIS A  49
GLY A 156
ASN A 155
EAX  A 401 (-3.3A)
None
None
EAX  A 401 (-3.4A)
1.37A 5a5zC-4p9kA:
undetectable
5a5zC-4p9kA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Polaromonas sp.
JS666)
PF03480
(DctP)
4 MET A 181
HIS A  49
GLY A 156
ASN A 155
EAX  A 401 (-3.3A)
None
None
EAX  A 401 (-3.4A)
1.36A 5a5zC-4pdhA:
undetectable
5a5zC-4pdhA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qav 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Neisseria
meningitidis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
4 CYH A 165
GLY A 406
ASN A 405
HIS A 303
None
1.17A 5a5zC-4qavA:
undetectable
5a5zC-4qavA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qex ERYTHROCYTE-BINDING
ANTIGEN-175


(Plasmodium
falciparum)
PF05424
(Duffy_binding)
4 HIS A 371
GLY A 317
ASN A 356
HIS A 285
None
1.11A 5a5zC-4qexA:
undetectable
5a5zC-4qexA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qor CATALASE

(Bacillus
pumilus)
PF00199
(Catalase)
PF06628
(Catalase-rel)
4 MET A 194
HIS A  57
GLY A 129
ASN A 130
None
HEM  A 501 ( 3.2A)
HEM  A 501 ( 3.8A)
HEM  A 502 ( 3.1A)
1.33A 5a5zC-4qorA:
undetectable
5a5zC-4qorA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Yersinia pestis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
4 CYH A 163
GLY A 405
ASN A 404
HIS A 303
None
1.22A 5a5zC-4r8eA:
undetectable
5a5zC-4r8eA:
20.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u4l BETA-LACTAMASE NDM-1

(Klebsiella
pneumoniae)
PF00753
(Lactamase_B)
6 MET A  67
HIS A 189
CYH A 208
LYS A 211
GLY A 219
HIS A 250
3C7  A 303 ( 3.5A)
ZN  A 301 ( 3.3A)
ZN  A 302 (-2.2A)
3C7  A 303 ( 4.8A)
None
3C7  A 303 ( 2.8A)
0.83A 5a5zC-4u4lA:
42.5
5a5zC-4u4lA:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ubq BETA-LACTAMASE

(Acinetobacter
baumannii)
no annotation 6 HIS A 140
CYH A 159
LYS A 162
GLY A 167
ASN A 168
HIS A 198
ZN  A 301 ( 3.3A)
ZN  A 302 (-1.8A)
ACT  A 303 (-2.8A)
ACT  A 303 ( 3.7A)
ACT  A 303 (-4.4A)
ZN  A 302 ( 3.8A)
0.61A 5a5zC-4ubqA:
31.3
5a5zC-4ubqA:
32.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6z ALCOHOL
DEHYDROGENASE 1


(Saccharomyces
cerevisiae)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 MET A 332
HIS A  66
CYH A 153
GLY A  41
8ID  A 403 ( 4.7A)
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.3A)
None
1.13A 5a5zC-4w6zA:
2.0
5a5zC-4w6zA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1


(Homo sapiens)
PF00155
(Aminotran_1_2)
4 MET A 266
CYH A 280
GLY A 102
HIS A 273
None
1.12A 5a5zC-4wlhA:
undetectable
5a5zC-4wlhA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE


(Schizosaccharomyces
pombe)
PF03031
(NIF)
PF12738
(PTCB-BRCT)
4 HIS A 414
GLY A 410
ASN A 411
HIS A 412
None
1.27A 5a5zC-4xpzA:
undetectable
5a5zC-4xpzA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z6k ALCOHOL
DEHYDROGENASE


(Moraxella sp.
TAE123)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 MET A 323
HIS A  61
CYH A 148
GLY A  36
None
ZN  A 401 (-3.3A)
ZN  A 401 (-2.3A)
None
0.94A 5a5zC-4z6kA:
undetectable
5a5zC-4z6kA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zej METALLO-BETA-LACTAMA
SE


(Pseudomonas
stutzeri)
no annotation 4 HIS A 139
CYH A 158
GLY A 169
HIS A 200
ZN  A 302 (-3.3A)
ZN  A 301 ( 2.1A)
CL  A 305 ( 4.5A)
ZN  A 301 ( 3.3A)
0.35A 5a5zC-4zejA:
32.1
5a5zC-4zejA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a01 O-GLYCOSYLTRANSFERAS
E


(Drosophila
melanogaster)
PF13374
(TPR_10)
PF13414
(TPR_11)
PF13844
(Glyco_transf_41)
4 HIS A 600
GLY A 594
ASN A 595
HIS A 596
None
1.04A 5a5zC-5a01A:
undetectable
5a5zC-5a01A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN


(Candidatus
Nitrososphaera
gargensis)
PF00561
(Abhydrolase_1)
4 MET A 258
HIS A 248
GLY A 124
ASN A 123
None
ACT  A 484 ( 4.8A)
None
None
1.29A 5a5zC-5a62A:
undetectable
5a5zC-5a62A:
22.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a87 METALLO-BETA-LACTAMA
SE VIM-5


(Klebsiella
pneumoniae)
PF00753
(Lactamase_B)
5 HIS A 179
CYH A 198
GLY A 209
ASN A 210
HIS A 240
ZN  A1263 (-3.2A)
ZN  A1265 (-2.2A)
None
GOL  A1262 (-4.1A)
ZN  A1265 ( 3.3A)
0.41A 5a5zC-5a87A:
33.3
5a5zC-5a87A:
35.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b3r IMP-18

(Pseudomonas
aeruginosa)
no annotation 6 HIS A 157
CYH A 176
LYS A 179
GLY A 184
ASN A 185
HIS A 215
ZN  A2001 ( 3.3A)
ZN  A2002 ( 2.2A)
CIT  A2003 (-2.6A)
CIT  A2003 (-3.6A)
CIT  A2003 (-4.0A)
ZN  A2002 ( 3.0A)
0.49A 5a5zC-5b3rA:
30.9
5a5zC-5b3rA:
33.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4y HOMOSERINE
O-ACETYLTRANSFERASE


(Pseudomonas
veronii)
PF00561
(Abhydrolase_1)
4 MET A 249
LYS A 260
GLY A  88
ASN A  89
None
1.40A 5a5zC-5e4yA:
undetectable
5a5zC-5e4yA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN


(Exiguobacterium
antarcticum)
PF00561
(Abhydrolase_1)
PF08386
(Abhydrolase_4)
4 HIS A 248
CYH A 223
GLY A 247
HIS A 216
F50  A 301 (-4.0A)
F50  A 301 ( 4.9A)
None
None
1.27A 5a5zC-5h3hA:
undetectable
5a5zC-5h3hA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ji5 BUPHA.10154.A.B1

(Paraburkholderia
phymatum)
PF00850
(Hist_deacetyl)
4 MET A 254
HIS A 125
GLY A 286
HIS A 165
None
None
ZN  A 401 ( 4.2A)
ZN  A 401 (-3.1A)
1.31A 5a5zC-5ji5A:
undetectable
5a5zC-5ji5A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE


(Caenorhabditis
elegans)
PF01676
(Metalloenzyme)
PF06415
(iPGM_N)
4 HIS A 468
GLY A  89
ASN A  85
HIS A 362
ZN  A 605 (-3.1A)
None
None
None
1.33A 5a5zC-5kgnA:
undetectable
5a5zC-5kgnA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE


(Acaryochloris
marina)
no annotation 4 HIS A 594
LYS A 428
GLY A 519
HIS A 513
PO4  A 901 (-4.1A)
PO4  A 901 (-2.8A)
PO4  A 901 (-3.2A)
PO4  A 901 (-4.3A)
1.14A 5a5zC-5lpcA:
undetectable
5a5zC-5lpcA:
17.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mmd METALLO-BETA-LACTAMA
SE 1


(Acinetobacter
baumannii)
PF00753
(Lactamase_B)
4 HIS E 196
CYH E 221
GLY E 232
HIS E 263
ZN  E 403 (-3.1A)
ZN  E 401 (-2.3A)
CL  E 404 ( 4.8A)
ZN  E 401 (-3.3A)
0.31A 5a5zC-5mmdE:
32.4
5a5zC-5mmdE:
34.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqo NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE


(Bacteroides
thetaiotaomicron)
PF07944
(Glyco_hydro_127)
4 HIS A 244
CYH A 241
GLY A 247
HIS A 196
None
1.32A 5a5zC-5mqoA:
undetectable
5a5zC-5mqoA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npr UDP-N-ACETYLGLUCOSAM
INE--PEPTIDE
N-ACETYLGLUCOSAMINYL
TRANSFERASE 110 KDA
SUBUNIT


(Homo sapiens)
no annotation 4 HIS A 562
GLY A 556
ASN A 557
HIS A 558
None
1.03A 5a5zC-5nprA:
undetectable
5a5zC-5nprA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot1 PULLULANASE TYPE II,
GH13 FAMILY


(Thermococcus
kodakarensis)
no annotation 4 HIS A 344
CYH A 343
GLY A 378
HIS A 381
None
0.67A 5a5zC-5ot1A:
undetectable
5a5zC-5ot1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpu 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE


(Acinetobacter
baumannii)
PF01676
(Metalloenzyme)
PF06415
(iPGM_N)
4 HIS A 445
GLY A  70
ASN A  66
HIS A 339
MN  A 602 ( 3.2A)
None
3PG  A 603 (-4.8A)
3PG  A 603 (-4.3A)
1.21A 5a5zC-5vpuA:
undetectable
5a5zC-5vpuA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6l RTX
REPEAT-CONTAINING
CYTOTOXIN


(Vibrio
vulnificus)
no annotation 4 MET A3674
GLY A3705
ASN A3704
HIS A3707
ALA  A3699 ( 3.5A)
GLY  A3705 ( 0.0A)
ASN  A3704 ( 0.6A)
HIS  A3707 ( 1.0A)
1.22A 5a5zC-5w6lA:
undetectable
5a5zC-5w6lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA


(Chaetomium
thermophilum)
no annotation 4 HIS B 687
CYH B 685
GLY B 696
ASN B 695
ZN  B8004 (-3.2A)
ZN  B8006 ( 2.3A)
None
None
1.21A 5a5zC-5wfcB:
undetectable
5a5zC-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yem CATALASE

(Mycothermus
thermophilus)
no annotation 4 MET A 223
HIS A  82
GLY A 154
ASN A 155
None
HEM  A 704 (-3.3A)
HEM  A 704 (-3.9A)
HEM  A 704 (-3.3A)
1.36A 5a5zC-5yemA:
undetectable
5a5zC-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE


(Escherichia
coli)
no annotation 4 MET A 212
HIS A 270
GLY A 175
ASN A 176
None
1.26A 5a5zC-5z03A:
undetectable
5a5zC-5z03A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5k NETRIN RECEPTOR DCC
DRAXIN


(Rattus
norvegicus;
Rattus
norvegicus)
no annotation
no annotation
4 LYS A  75
GLY A 368
ASN A 367
HIS B 269
None
1.07A 5a5zC-5z5kA:
undetectable
5a5zC-5z5kA:
undetectable