SIMILAR PATTERNS OF AMINO ACIDS FOR 5A5Z_C_WJZC304
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ddk | IMP-1 METALLOBETA-LACTAMASE (Pseudomonasaeruginosa) |
PF00753(Lactamase_B) | 6 | HIS A 139CYH A 158LYS A 161GLY A 166ASN A 167HIS A 197 | ZN A 500 (-3.3A) ZN A 501 ( 2.4A) ZN A 501 ( 4.5A)NoneACY A 510 (-4.4A) ZN A 501 ( 3.4A) | 0.58A | 5a5zC-1ddkA:30.9 | 5a5zC-1ddkA:33.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dgf | CATALASE (Homo sapiens) |
PF00199(Catalase)PF06628(Catalase-rel) | 4 | MET A 212HIS A 75GLY A 147ASN A 148 | NoneHEM A3000 (-3.4A)HEM A3000 (-3.8A)HEM A3000 (-3.4A) | 1.37A | 5a5zC-1dgfA:undetectable | 5a5zC-1dgfA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eak | 72 KDA TYPE IVCOLLAGENASE (Homo sapiens) |
PF00040(fn2)PF00413(Peptidase_M10)PF01471(PG_binding_1) | 4 | HIS A 413GLY A 103ASN A 104HIS A 403 | ZN A 997 (-3.5A)NoneNone ZN A 997 (-3.5A) | 1.38A | 5a5zC-1eakA:undetectable | 5a5zC-1eakA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hbz | CATALASE (Micrococcusluteus) |
PF00199(Catalase)PF06628(Catalase-rel) | 4 | MET A 197HIS A 61GLY A 132ASN A 133 | NoneHEM A 504 (-3.3A)HEM A 504 (-3.8A)HEM A 504 (-3.2A) | 1.31A | 5a5zC-1hbzA:undetectable | 5a5zC-1hbzA:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hlk | BETA-LACTAMASE, TYPEII (Bacteroidesfragilis) |
no annotation | 5 | HIS A 162CYH A 181GLY A 192ASN A 193HIS A 223 | ZN A1001 (-3.3A) ZN A1002 ( 2.1A)113 A2002 ( 3.8A)113 A2002 (-4.1A)113 A2002 ( 3.6A) | 0.50A | 5a5zC-1hlkA:32.2 | 5a5zC-1hlkA:29.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hlk | BETA-LACTAMASE, TYPEII (Bacteroidesfragilis) |
no annotation | 4 | HIS A 162LYS A 184GLY A 192ASN A 193 | ZN A1001 (-3.3A)113 A2002 (-3.6A)113 A2002 ( 3.8A)113 A2002 (-4.1A) | 0.82A | 5a5zC-1hlkA:32.2 | 5a5zC-1hlkA:29.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ikp | EXOTOXIN A (Pseudomonasaeruginosa) |
PF09009(Exotox-A_cataly)PF09101(Exotox-A_bind)PF09102(Exotox-A_target) | 4 | HIS A 107LYS A 185GLY A 39ASN A 38 | None | 0.87A | 5a5zC-1ikpA:undetectable | 5a5zC-1ikpA:18.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kq0 | METHIONINEAMINOPEPTIDASE 2 (Homo sapiens) |
PF00557(Peptidase_M24) | 4 | MET A 184HIS A 460GLY A 475HIS A 176 | TBU A 501 ( 4.1A)NoneNoneNone | 1.30A | 5a5zC-1kq0A:undetectable | 5a5zC-1kq0A:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1llu | ALCOHOLDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | MET A 329HIS A 67CYH A 154GLY A 42 | NAD A1250 ( 4.4A) ZN A 343 ( 3.3A) ZN A 343 ( 2.4A)None | 1.14A | 5a5zC-1lluA:undetectable | 5a5zC-1lluA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m2x | CLASS BCARBAPENEMASE BLAB-1 (Elizabethkingiameningoseptica) |
PF00753(Lactamase_B) | 5 | HIS A 196CYH A 221LYS A 224GLY A 232HIS A 263 | ZN A 901 ( 3.2A) ZN A 902 (-2.3A)NoneNone ZN A 902 (-3.2A) | 0.70A | 5a5zC-1m2xA:29.3 | 5a5zC-1m2xA:25.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m7s | CATALASE (Pseudomonassyringae) |
PF00199(Catalase)PF06628(Catalase-rel) | 4 | MET A 214HIS A 78GLY A 149ASN A 150 | NoneHEM A 600 (-3.3A)HEM A 600 (-4.0A)HEM A 600 (-3.4A) | 1.31A | 5a5zC-1m7sA:undetectable | 5a5zC-1m7sA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qf7 | PROTEIN (CATALASEHPII) (Escherichiacoli) |
PF00199(Catalase)PF06628(Catalase-rel) | 4 | MET A 269HIS A 128GLY A 200ASN A 201 | NoneHEM A 754 ( 3.3A)HEM A 754 (-3.8A)HEM A 754 ( 3.4A) | 1.32A | 5a5zC-1qf7A:undetectable | 5a5zC-1qf7A:15.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1si8 | CATALASE (Enterococcusfaecalis) |
PF00199(Catalase)PF06628(Catalase-rel) | 4 | MET A 191HIS A 54GLY A 126ASN A 127 | NoneHEM A 501 (-3.5A)HEM A 501 (-3.8A)HEM A 501 (-3.2A) | 1.39A | 5a5zC-1si8A:undetectable | 5a5zC-1si8A:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1su7 | CARBON MONOXIDEDEHYDROGENASE 2 (Carboxydothermushydrogenoformans) |
PF03063(Prismane) | 4 | HIS A 561CYH A 333GLY A 92HIS A 261 | NFS A 639 (-4.5A)NFS A 639 (-2.2A)NoneNFS A 639 (-3.3A) | 1.14A | 5a5zC-1su7A:undetectable | 5a5zC-1su7A:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sy7 | CATALASE 1 (Neurosporacrassa) |
PF00199(Catalase)PF01965(DJ-1_PfpI)PF06628(Catalase-rel) | 4 | MET A 233HIS A 92GLY A 164ASN A 165 | NoneHEM A1883 ( 3.5A)HDD A1880 ( 3.9A)HDD A1880 ( 3.1A) | 1.34A | 5a5zC-1sy7A:undetectable | 5a5zC-1sy7A:16.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wew | DNA-BINDING FAMILYPROTEIN (Arabidopsisthaliana) |
PF00628(PHD) | 4 | HIS A 43CYH A 46GLY A 22ASN A 23 | ZN A 201 (-3.4A) ZN A 201 (-2.3A)NoneNone | 1.12A | 5a5zC-1wewA:undetectable | 5a5zC-1wewA:14.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x2b | PROLINEIMINOPEPTIDASE (Serratiamarcescens) |
PF00561(Abhydrolase_1) | 4 | HIS A 296CYH A 271GLY A 295HIS A 264 | STX A 401 (-4.5A)STX A 401 ( 4.9A)NoneNone | 1.38A | 5a5zC-1x2bA:undetectable | 5a5zC-1x2bA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2adu | METHIONINEAMINOPEPTIDASE 2 (Homo sapiens) |
PF00557(Peptidase_M24) | 4 | MET A 184HIS A 460GLY A 475HIS A 176 | None | 1.25A | 5a5zC-2aduA:undetectable | 5a5zC-2aduA:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2afh | NITROGENASEMOLYBDENUM-IRONPROTEIN (Azotobactervinelandii) |
PF00148(Oxidored_nitro)PF11844(DUF3364) | 4 | MET B 213GLY B 219ASN B 286HIS B 311 | None | 1.23A | 5a5zC-2afhB:undetectable | 5a5zC-2afhB:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bq8 | TARTRATE-RESISTANTACID PHOSPHATASETYPE 5 (Homo sapiens) |
PF00149(Metallophos) | 4 | HIS X 90GLY X 88ASN X 89HIS X 219 | NoneNoneNoneFE2 X1306 (-3.2A) | 0.98A | 5a5zC-2bq8X:undetectable | 5a5zC-2bq8X:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ess | ACYL-ACPTHIOESTERASE (Bacteroidesthetaiotaomicron) |
PF01643(Acyl-ACP_TE) | 4 | HIS A 33GLY A 28ASN A 32HIS A 18 | CL A 251 (-4.3A)NoneNone CL A 251 (-3.9A) | 1.16A | 5a5zC-2essA:undetectable | 5a5zC-2essA:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ew2 | 2-DEHYDROPANTOATE2-REDUCTASE,PUTATIVE (Enterococcusfaecalis) |
PF02558(ApbA)PF08546(ApbA_C) | 4 | MET A 262GLY A 280ASN A 279HIS A 304 | None | 1.33A | 5a5zC-2ew2A:undetectable | 5a5zC-2ew2A:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fhx | SPM-1 (Pseudomonasaeruginosa) |
PF00753(Lactamase_B) | 4 | HIS B 196LYS B 224GLY B 232HIS B 263 | ZN B 317 ( 3.2A)AZI B 402 (-2.9A)AZI B 402 ( 3.7A)CSO B 221 (-3.5A) | 0.62A | 5a5zC-2fhxB:28.8 | 5a5zC-2fhxB:25.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iqf | CATALASE (Helicobacterpylori) |
PF00199(Catalase)PF06628(Catalase-rel) | 4 | MET A 193HIS A 56GLY A 128ASN A 129 | NoneHEM A 550 ( 3.4A)HEM A 550 (-3.9A)HEM A 550 (-3.2A) | 1.39A | 5a5zC-2iqfA:undetectable | 5a5zC-2iqfA:18.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2isa | CATALASE (Aliivibriosalmonicida) |
PF00199(Catalase)PF06628(Catalase-rel) | 4 | MET A 191HIS A 54GLY A 126ASN A 127 | NoneHEM A 486 (-3.4A)HEM A 486 (-4.1A)HEM A 486 (-3.4A) | 1.36A | 5a5zC-2isaA:undetectable | 5a5zC-2isaA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j2m | CATALASE (Exiguobacteriumoxidotolerans) |
PF00199(Catalase)PF06628(Catalase-rel) | 4 | MET A 193HIS A 56GLY A 128ASN A 129 | NoneHEM A 501 (-3.3A)HEM A 501 (-3.7A)HEM A 501 (-3.6A) | 1.39A | 5a5zC-2j2mA:undetectable | 5a5zC-2j2mA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kak | EC PROTEIN I/II (Triticumaestivum) |
PF02068(Metallothio_PEC) | 4 | CYH A 47GLY A 43ASN A 45HIS A 41 | ZN A 130 ( 2.3A)NoneNone ZN A 130 (-3.1A) | 1.33A | 5a5zC-2kakA:undetectable | 5a5zC-2kakA:9.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2nyp | BETA-LACTAMASE II (Bacillus cereus) |
PF00753(Lactamase_B) | 5 | HIS A 149LYS A 171GLY A 179ASN A 180HIS A 210 | ZN A 301 (-3.2A)NoneNoneNone ZN A 302 (-4.1A) | 0.53A | 5a5zC-2nypA:30.8 | 5a5zC-2nypA:32.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2nyp | BETA-LACTAMASE II (Bacillus cereus) |
PF00753(Lactamase_B) | 4 | HIS A 210LYS A 171GLY A 167HIS A 149 | ZN A 302 (-4.1A)NoneNone ZN A 301 (-3.2A) | 1.17A | 5a5zC-2nypA:30.8 | 5a5zC-2nypA:32.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pbg | 6-PHOSPHO-BETA-D-GALACTOSIDASE (Lactococcuslactis) |
PF00232(Glyco_hydro_1) | 4 | HIS A 196GLY A 213ASN A 291HIS A 216 | None | 1.16A | 5a5zC-2pbgA:undetectable | 5a5zC-2pbgA:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q9u | A-TYPE FLAVOPROTEIN (Giardiaintestinalis) |
no annotation | 4 | HIS A 230GLY A 172ASN A 170HIS A 152 | FEO A 701 ( 3.3A)NoneNoneFEO A 701 ( 3.4A) | 1.23A | 5a5zC-2q9uA:17.3 | 5a5zC-2q9uA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uu7 | GLUTAMINE SYNTHETASE (Canis lupus) |
PF00120(Gln-synt_C)PF03951(Gln-synt_N) | 4 | HIS A 304LYS A 241GLY A 245ASN A 246 | None | 0.99A | 5a5zC-2uu7A:undetectable | 5a5zC-2uu7A:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w8d | PROCESSED GLYCEROLPHOSPHATELIPOTEICHOIC ACIDSYNTHASE 2 (Bacillussubtilis) |
PF00884(Sulfatase) | 4 | HIS A 343GLY A 381ASN A 345HIS A 412 | NoneNoneNoneTPO A 297 ( 4.0A) | 1.08A | 5a5zC-2w8dA:undetectable | 5a5zC-2w8dA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ynt | GIM-1 PROTEIN (Pseudomonasaeruginosa) |
PF00753(Lactamase_B) | 4 | HIS B 196CYH B 221GLY B 232HIS B 263 | ZN B1297 (-3.2A) ZN B1298 (-2.2A)None ZN B1298 (-3.2A) | 0.35A | 5a5zC-2yntB:32.1 | 5a5zC-2yntB:29.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3abg | BILIRUBIN OXIDASE (Albifimbriaverrucaria) |
PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | HIS A 398CYH A 457GLY A 365ASN A 364 | CU A 704 (-3.5A) CU A 704 (-2.3A)NoneNone | 1.39A | 5a5zC-3abgA:undetectable | 5a5zC-3abgA:17.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dhn | NAD-DEPENDENTEPIMERASE/DEHYDRATASE (Bacteroidesthetaiotaomicron) |
PF13460(NAD_binding_10) | 4 | HIS A 191GLY A 188ASN A 189HIS A 222 | None | 1.39A | 5a5zC-3dhnA:undetectable | 5a5zC-3dhnA:25.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eeq | PUTATIVE COBALAMINBIOSYNTHESIS PROTEING HOMOLOG (Sulfolobussolfataricus) |
PF01890(CbiG_C)PF11760(CbiG_N) | 4 | LYS A 136GLY A 109ASN A 111HIS A 107 | NoneNoneSO4 A 2 (-3.9A)None | 1.24A | 5a5zC-3eeqA:undetectable | 5a5zC-3eeqA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eya | PYRUVATEDEHYDROGENASE[CYTOCHROME] (Escherichiacoli) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 4 | MET A 438HIS A 405GLY A 84ASN A 83 | TDP A 611 ( 3.7A)NoneNoneNone | 1.16A | 5a5zC-3eyaA:undetectable | 5a5zC-3eyaA:17.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fai | BETA-LACTAMASE (Aeromonashydrophila) |
PF00753(Lactamase_B) | 5 | HIS A 196CYH A 221LYS A 224GLY A 232HIS A 263 | ZN A 2 ( 3.2A) ZN A 1 ( 2.2A)SO4 A 311 ( 4.7A)GOL A 320 (-3.5A) ZN A 1 ( 3.2A) | 0.75A | 5a5zC-3faiA:27.5 | 5a5zC-3faiA:27.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fai | BETA-LACTAMASE (Aeromonashydrophila) |
PF00753(Lactamase_B) | 4 | HIS A 196LYS A 224GLY A 232ASN A 233 | ZN A 2 ( 3.2A)SO4 A 311 ( 4.7A)GOL A 320 (-3.5A)None | 0.80A | 5a5zC-3faiA:27.5 | 5a5zC-3faiA:27.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h6e | CARBOHYDRATE KINASE,FGGY (Novosphingobiumaromaticivorans) |
PF00370(FGGY_N) | 4 | HIS A 172GLY A 170ASN A 283HIS A 230 | None | 1.31A | 5a5zC-3h6eA:undetectable | 5a5zC-3h6eA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hbj | FLAVONOID3-O-GLUCOSYLTRANSFERASE (Medicagotruncatula) |
PF00201(UDPGT) | 4 | MET A 368HIS A 150GLY A 378ASN A 380 | None | 1.00A | 5a5zC-3hbjA:undetectable | 5a5zC-3hbjA:18.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | PRE-MRNA-SPLICINGFACTOR CWF10 (Schizosaccharomycespombe) |
PF00009(GTP_EFTU)PF00679(EFG_C)PF03144(GTP_EFTU_D2)PF03764(EFG_IV)PF16004(EFTUD2) | 4 | MET B 597LYS B 154GLY B 219ASN B 250 | NoneGDP B1000 ( 3.5A)GDP B1000 ( 4.7A)None | 1.29A | 5a5zC-3jb9B:undetectable | 5a5zC-3jb9B:13.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k7d | GLUTAMATE-AMMONIA-LIGASEADENYLYLTRANSFERASE (Escherichiacoli) |
PF03710(GlnE)PF08335(GlnD_UR_UTase) | 4 | HIS A 674CYH A 710GLY A 682HIS A 708 | None | 1.26A | 5a5zC-3k7dA:undetectable | 5a5zC-3k7dA:17.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kie | CAPSID PROTEIN VP1 (Adeno-associateddependoparvovirusA) |
PF00740(Parvo_coat) | 4 | HIS A 229LYS A 314GLY A 226ASN A 227 | None | 1.21A | 5a5zC-3kieA:undetectable | 5a5zC-3kieA:15.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kzw | CYTOSOLAMINOPEPTIDASE (Staphylococcusaureus) |
PF00883(Peptidase_M17)PF02789(Peptidase_M17_N) | 4 | HIS A 431LYS A 437GLY A 434ASN A 433 | None | 1.34A | 5a5zC-3kzwA:undetectable | 5a5zC-3kzwA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l6n | METALLO-BETA-LACTAMASE (Chryseobacteriumindologenes) |
PF00753(Lactamase_B) | 5 | HIS A 159CYH A 178LYS A 181GLY A 189HIS A 220 | ZN A 301 (-3.2A) ZN A 302 (-2.0A)NoneNone ZN A 302 (-3.6A) | 0.88A | 5a5zC-3l6nA:28.1 | 5a5zC-3l6nA:26.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3la8 | PUTATIVE PURINENUCLEOSIDEPHOSPHORYLASE (Streptococcusmutans) |
PF01048(PNP_UDP_1) | 4 | MET A 90HIS A 130GLY A 184ASN A 132 | None | 1.20A | 5a5zC-3la8A:undetectable | 5a5zC-3la8A:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3meq | ALCOHOLDEHYDROGENASE,ZINC-CONTAINING (Brucella suis) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | MET A 329HIS A 65CYH A 152GLY A 40 | NAI A 601 ( 4.5A) ZN A 401 ( 3.2A) ZN A 401 (-2.2A)None | 1.05A | 5a5zC-3meqA:undetectable | 5a5zC-3meqA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3orw | PHOSPHOTRIESTERASE (Geobacilluskaustophilus) |
PF02126(PTE) | 4 | HIS A 290GLY A 232ASN A 288HIS A 265 | None | 1.37A | 5a5zC-3orwA:undetectable | 5a5zC-3orwA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3our | PHOSPHOTRANSFERASESYSTEM IIA COMPONENT (Vibriovulnificus) |
PF00358(PTS_EIIA_1) | 4 | MET B 60GLY B 101ASN B 75HIS B 76 | None | 1.29A | 5a5zC-3ourB:undetectable | 5a5zC-3ourB:23.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q6v | BETA-LACTAMASE (Serratiafonticola) |
PF00753(Lactamase_B) | 6 | HIS A 196CYH A 221LYS A 224GLY A 232ASN A 233HIS A 263 | GOL A 1 (-3.5A) ZN A 2 ( 2.2A)GOL A 1 ( 4.6A)NoneGOL A 1 (-3.4A) ZN A 2 ( 3.3A) | 0.60A | 5a5zC-3q6vA:27.2 | 5a5zC-3q6vA:23.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ra2 | CAPSID PROTEIN (Adeno-associateddependoparvovirusA) |
PF00740(Parvo_coat) | 4 | HIS A 230LYS A 317GLY A 227ASN A 228 | None | 1.29A | 5a5zC-3ra2A:undetectable | 5a5zC-3ra2A:16.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t8l | ADENINE DEAMINASE 2 (Agrobacteriumfabrum) |
PF01979(Amidohydro_1)PF13382(Adenine_deam_C) | 4 | HIS A 480GLY A 125ASN A 126HIS A 122 | NoneNoneNoneUNX A 607 ( 3.5A) | 1.38A | 5a5zC-3t8lA:undetectable | 5a5zC-3t8lA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t8l | ADENINE DEAMINASE 2 (Agrobacteriumfabrum) |
PF01979(Amidohydro_1)PF13382(Adenine_deam_C) | 4 | MET A 189HIS A 480GLY A 125ASN A 126 | None | 1.31A | 5a5zC-3t8lA:undetectable | 5a5zC-3t8lA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tp9 | BETA-LACTAMASE ANDRHODANESE DOMAINPROTEIN (Alicyclobacillusacidocaldarius) |
PF00581(Rhodanese)PF00753(Lactamase_B) | 4 | HIS A 196CYH A 202GLY A 145HIS A 120 | None ZN A 472 (-3.1A)None ZN A 472 (-3.4A) | 0.86A | 5a5zC-3tp9A:3.1 | 5a5zC-3tp9A:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wfj | 2-DEHYDROPANTOATE2-REDUCTASE (Enterococcusfaecium) |
PF02558(ApbA)PF08546(ApbA_C) | 4 | MET A 261GLY A 279ASN A 278HIS A 303 | None | 1.27A | 5a5zC-3wfjA:undetectable | 5a5zC-3wfjA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cab | CATALASE (Deinococcusradiodurans) |
PF00199(Catalase)PF06628(Catalase-rel) | 4 | MET A 223HIS A 81GLY A 158ASN A 159 | NoneHEM A 537 (-3.4A)HEM A 537 (-4.0A)HEM A 537 (-3.5A) | 1.29A | 5a5zC-4cabA:undetectable | 5a5zC-4cabA:18.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4d1t | METALLO-B-LACTAMASE (Pseudomonasaeruginosa) |
PF00753(Lactamase_B) | 5 | HIS A 196CYH A 221GLY A 232ASN A 233HIS A 263 | ZN A1292 (-3.2A) ZN A1293 (-2.3A)NoneNone ZN A1293 (-3.3A) | 0.73A | 5a5zC-4d1tA:33.4 | 5a5zC-4d1tA:32.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eex | ALCOHOLDEHYDROGENASE 1 (Lactococcuslactis) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | MET A 325HIS A 60CYH A 147GLY A 37 | None ZN A 402 (-3.2A) ZN A 402 (-2.3A)None | 1.08A | 5a5zC-4eexA:2.2 | 5a5zC-4eexA:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ewg | BETA-KETOACYLSYNTHASE (Paraburkholderiaphymatum) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 4 | CYH A 340LYS A 330GLY A 302HIS A 335 | None | 1.03A | 5a5zC-4ewgA:undetectable | 5a5zC-4ewgA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gkv | ALCOHOLDEHYDROGENASE,PROPANOL-PREFERRING (Escherichiacoli) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | MET A 321HIS A 58CYH A 145GLY A 35 | NAD A 401 (-4.3A) ZN A 402 (-3.3A) ZN A 402 ( 2.3A)None | 1.07A | 5a5zC-4gkvA:undetectable | 5a5zC-4gkvA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4if2 | PHOSPHOTRIESTERASEHOMOLOGY PROTEIN (Mycobacteriumtuberculosis) |
PF02126(PTE) | 4 | HIS A 285GLY A 233ASN A 283HIS A 263 | None | 1.39A | 5a5zC-4if2A:undetectable | 5a5zC-4if2A:22.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jhp | X-LINKED RETINITISPIGMENTOSA GTPASEREGULATOR (Homo sapiens) |
PF00415(RCC1) | 4 | CYH C 302GLY C 320ASN C 305HIS C 254 | None | 1.31A | 5a5zC-4jhpC:undetectable | 5a5zC-4jhpC:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jhp | X-LINKED RETINITISPIGMENTOSA GTPASEREGULATOR (Homo sapiens) |
PF00415(RCC1) | 4 | HIS C 98GLY C 112ASN C 97HIS C 46 | None | 1.30A | 5a5zC-4jhpC:undetectable | 5a5zC-4jhpC:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jrm | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Vibrio cholerae) |
no annotation | 4 | CYH D 164GLY D 407ASN D 406HIS D 304 | None | 1.19A | 5a5zC-4jrmD:undetectable | 5a5zC-4jrmD:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ns1 | PURINE NUCLEOSIDEPHOSPHORYLASE (Porphyromonasgingivalis) |
PF01048(PNP_UDP_1) | 4 | MET A 106HIS A 148GLY A 201ASN A 150 | None | 1.19A | 5a5zC-4ns1A:undetectable | 5a5zC-4ns1A:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4opu | CONSERVED ARCHAEALPROTEIN (Sulfolobusacidocaldarius) |
PF01266(DAO) | 4 | HIS A 297GLY A 300ASN A 294HIS A 55 | GRG A 502 ( 4.1A)FDA A 501 (-3.2A)GRG A 503 (-4.6A)GRG A 503 (-3.4A) | 1.32A | 5a5zC-4opuA:undetectable | 5a5zC-4opuA:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p9k | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Verminephrobactereiseniae) |
PF03480(DctP) | 4 | MET A 181HIS A 49GLY A 156ASN A 155 | EAX A 401 (-3.3A)NoneNoneEAX A 401 (-3.4A) | 1.37A | 5a5zC-4p9kA:undetectable | 5a5zC-4p9kA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pdh | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Polaromonas sp.JS666) |
PF03480(DctP) | 4 | MET A 181HIS A 49GLY A 156ASN A 155 | EAX A 401 (-3.3A)NoneNoneEAX A 401 (-3.4A) | 1.36A | 5a5zC-4pdhA:undetectable | 5a5zC-4pdhA:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qav | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Neisseriameningitidis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 4 | CYH A 165GLY A 406ASN A 405HIS A 303 | None | 1.17A | 5a5zC-4qavA:undetectable | 5a5zC-4qavA:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qex | ERYTHROCYTE-BINDINGANTIGEN-175 (Plasmodiumfalciparum) |
PF05424(Duffy_binding) | 4 | HIS A 371GLY A 317ASN A 356HIS A 285 | None | 1.11A | 5a5zC-4qexA:undetectable | 5a5zC-4qexA:13.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qor | CATALASE (Bacilluspumilus) |
PF00199(Catalase)PF06628(Catalase-rel) | 4 | MET A 194HIS A 57GLY A 129ASN A 130 | NoneHEM A 501 ( 3.2A)HEM A 501 ( 3.8A)HEM A 502 ( 3.1A) | 1.33A | 5a5zC-4qorA:undetectable | 5a5zC-4qorA:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r8e | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Yersinia pestis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 4 | CYH A 163GLY A 405ASN A 404HIS A 303 | None | 1.22A | 5a5zC-4r8eA:undetectable | 5a5zC-4r8eA:20.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4u4l | BETA-LACTAMASE NDM-1 (Klebsiellapneumoniae) |
PF00753(Lactamase_B) | 6 | MET A 67HIS A 189CYH A 208LYS A 211GLY A 219HIS A 250 | 3C7 A 303 ( 3.5A) ZN A 301 ( 3.3A) ZN A 302 (-2.2A)3C7 A 303 ( 4.8A)None3C7 A 303 ( 2.8A) | 0.83A | 5a5zC-4u4lA:42.5 | 5a5zC-4u4lA:99.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ubq | BETA-LACTAMASE (Acinetobacterbaumannii) |
no annotation | 6 | HIS A 140CYH A 159LYS A 162GLY A 167ASN A 168HIS A 198 | ZN A 301 ( 3.3A) ZN A 302 (-1.8A)ACT A 303 (-2.8A)ACT A 303 ( 3.7A)ACT A 303 (-4.4A) ZN A 302 ( 3.8A) | 0.61A | 5a5zC-4ubqA:31.3 | 5a5zC-4ubqA:32.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w6z | ALCOHOLDEHYDROGENASE 1 (Saccharomycescerevisiae) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | MET A 332HIS A 66CYH A 153GLY A 41 | 8ID A 403 ( 4.7A) ZN A 401 ( 3.1A) ZN A 401 (-2.3A)None | 1.13A | 5a5zC-4w6zA:2.0 | 5a5zC-4w6zA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wlh | KYNURENINE--OXOGLUTARATE TRANSAMINASE 1 (Homo sapiens) |
PF00155(Aminotran_1_2) | 4 | MET A 266CYH A 280GLY A 102HIS A 273 | None | 1.12A | 5a5zC-4wlhA:undetectable | 5a5zC-4wlhA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xpz | RNA POLYMERASE IISUBUNIT A C-TERMINALDOMAIN PHOSPHATASE (Schizosaccharomycespombe) |
PF03031(NIF)PF12738(PTCB-BRCT) | 4 | HIS A 414GLY A 410ASN A 411HIS A 412 | None | 1.27A | 5a5zC-4xpzA:undetectable | 5a5zC-4xpzA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z6k | ALCOHOLDEHYDROGENASE (Moraxella sp.TAE123) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | MET A 323HIS A 61CYH A 148GLY A 36 | None ZN A 401 (-3.3A) ZN A 401 (-2.3A)None | 0.94A | 5a5zC-4z6kA:undetectable | 5a5zC-4z6kA:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zej | METALLO-BETA-LACTAMASE (Pseudomonasstutzeri) |
no annotation | 4 | HIS A 139CYH A 158GLY A 169HIS A 200 | ZN A 302 (-3.3A) ZN A 301 ( 2.1A) CL A 305 ( 4.5A) ZN A 301 ( 3.3A) | 0.35A | 5a5zC-4zejA:32.1 | 5a5zC-4zejA:29.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a01 | O-GLYCOSYLTRANSFERASE (Drosophilamelanogaster) |
PF13374(TPR_10)PF13414(TPR_11)PF13844(Glyco_transf_41) | 4 | HIS A 600GLY A 594ASN A 595HIS A 596 | None | 1.04A | 5a5zC-5a01A:undetectable | 5a5zC-5a01A:15.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a62 | PUTATIVE ALPHA/BETAHYDROLASE FOLDPROTEIN (CandidatusNitrososphaeragargensis) |
PF00561(Abhydrolase_1) | 4 | MET A 258HIS A 248GLY A 124ASN A 123 | NoneACT A 484 ( 4.8A)NoneNone | 1.29A | 5a5zC-5a62A:undetectable | 5a5zC-5a62A:22.55 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5a87 | METALLO-BETA-LACTAMASE VIM-5 (Klebsiellapneumoniae) |
PF00753(Lactamase_B) | 5 | HIS A 179CYH A 198GLY A 209ASN A 210HIS A 240 | ZN A1263 (-3.2A) ZN A1265 (-2.2A)NoneGOL A1262 (-4.1A) ZN A1265 ( 3.3A) | 0.41A | 5a5zC-5a87A:33.3 | 5a5zC-5a87A:35.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5b3r | IMP-18 (Pseudomonasaeruginosa) |
no annotation | 6 | HIS A 157CYH A 176LYS A 179GLY A 184ASN A 185HIS A 215 | ZN A2001 ( 3.3A) ZN A2002 ( 2.2A)CIT A2003 (-2.6A)CIT A2003 (-3.6A)CIT A2003 (-4.0A) ZN A2002 ( 3.0A) | 0.49A | 5a5zC-5b3rA:30.9 | 5a5zC-5b3rA:33.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e4y | HOMOSERINEO-ACETYLTRANSFERASE (Pseudomonasveronii) |
PF00561(Abhydrolase_1) | 4 | MET A 249LYS A 260GLY A 88ASN A 89 | None | 1.40A | 5a5zC-5e4yA:undetectable | 5a5zC-5e4yA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h3h | ABHYDROLASEDOMAIN-CONTAININGPROTEIN (Exiguobacteriumantarcticum) |
PF00561(Abhydrolase_1)PF08386(Abhydrolase_4) | 4 | HIS A 248CYH A 223GLY A 247HIS A 216 | F50 A 301 (-4.0A)F50 A 301 ( 4.9A)NoneNone | 1.27A | 5a5zC-5h3hA:undetectable | 5a5zC-5h3hA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ji5 | BUPHA.10154.A.B1 (Paraburkholderiaphymatum) |
PF00850(Hist_deacetyl) | 4 | MET A 254HIS A 125GLY A 286HIS A 165 | NoneNone ZN A 401 ( 4.2A) ZN A 401 (-3.1A) | 1.31A | 5a5zC-5ji5A:undetectable | 5a5zC-5ji5A:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kgn | 2,3-BISPHOSPHOGLYCERATE-INDEPENDENTPHOSPHOGLYCERATEMUTASE (Caenorhabditiselegans) |
PF01676(Metalloenzyme)PF06415(iPGM_N) | 4 | HIS A 468GLY A 89ASN A 85HIS A 362 | ZN A 605 (-3.1A)NoneNoneNone | 1.33A | 5a5zC-5kgnA:undetectable | 5a5zC-5kgnA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lpc | VANADIUM-DEPENDENTBROMOPEROXIDASE (Acaryochlorismarina) |
no annotation | 4 | HIS A 594LYS A 428GLY A 519HIS A 513 | PO4 A 901 (-4.1A)PO4 A 901 (-2.8A)PO4 A 901 (-3.2A)PO4 A 901 (-4.3A) | 1.14A | 5a5zC-5lpcA:undetectable | 5a5zC-5lpcA:17.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5mmd | METALLO-BETA-LACTAMASE 1 (Acinetobacterbaumannii) |
PF00753(Lactamase_B) | 4 | HIS E 196CYH E 221GLY E 232HIS E 263 | ZN E 403 (-3.1A) ZN E 401 (-2.3A) CL E 404 ( 4.8A) ZN E 401 (-3.3A) | 0.31A | 5a5zC-5mmdE:32.4 | 5a5zC-5mmdE:34.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mqo | NON-REDUCING ENDBETA-L-ARABINOFURANOSIDASE (Bacteroidesthetaiotaomicron) |
PF07944(Glyco_hydro_127) | 4 | HIS A 244CYH A 241GLY A 247HIS A 196 | None | 1.32A | 5a5zC-5mqoA:undetectable | 5a5zC-5mqoA:17.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5npr | UDP-N-ACETYLGLUCOSAMINE--PEPTIDEN-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDASUBUNIT (Homo sapiens) |
no annotation | 4 | HIS A 562GLY A 556ASN A 557HIS A 558 | None | 1.03A | 5a5zC-5nprA:undetectable | 5a5zC-5nprA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ot1 | PULLULANASE TYPE II,GH13 FAMILY (Thermococcuskodakarensis) |
no annotation | 4 | HIS A 344CYH A 343GLY A 378HIS A 381 | None | 0.67A | 5a5zC-5ot1A:undetectable | 5a5zC-5ot1A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vpu | 2,3-BISPHOSPHOGLYCERATE-INDEPENDENTPHOSPHOGLYCERATEMUTASE (Acinetobacterbaumannii) |
PF01676(Metalloenzyme)PF06415(iPGM_N) | 4 | HIS A 445GLY A 70ASN A 66HIS A 339 | MN A 602 ( 3.2A)None3PG A 603 (-4.8A)3PG A 603 (-4.3A) | 1.21A | 5a5zC-5vpuA:undetectable | 5a5zC-5vpuA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w6l | RTXREPEAT-CONTAININGCYTOTOXIN (Vibriovulnificus) |
no annotation | 4 | MET A3674GLY A3705ASN A3704HIS A3707 | ALA A3699 ( 3.5A)GLY A3705 ( 0.0A)ASN A3704 ( 0.6A)HIS A3707 ( 1.0A) | 1.22A | 5a5zC-5w6lA:undetectable | 5a5zC-5w6lA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wfc | HISTONE-LYSINE-N-METHYLTRANSFERASE EZH2,POLYCOMB PROTEINSUZ12 CHIMERA (Chaetomiumthermophilum) |
no annotation | 4 | HIS B 687CYH B 685GLY B 696ASN B 695 | ZN B8004 (-3.2A) ZN B8006 ( 2.3A)NoneNone | 1.21A | 5a5zC-5wfcB:undetectable | 5a5zC-5wfcB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yem | CATALASE (Mycothermusthermophilus) |
no annotation | 4 | MET A 223HIS A 82GLY A 154ASN A 155 | NoneHEM A 704 (-3.3A)HEM A 704 (-3.9A)HEM A 704 (-3.3A) | 1.36A | 5a5zC-5yemA:undetectable | 5a5zC-5yemA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z03 | MUREIN TETRAPEPTIDECARBOXYPEPTIDASE (Escherichiacoli) |
no annotation | 4 | MET A 212HIS A 270GLY A 175ASN A 176 | None | 1.26A | 5a5zC-5z03A:undetectable | 5a5zC-5z03A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z5k | NETRIN RECEPTOR DCCDRAXIN (Rattusnorvegicus;Rattusnorvegicus) |
no annotationno annotation | 4 | LYS A 75GLY A 368ASN A 367HIS B 269 | None | 1.07A | 5a5zC-5z5kA:undetectable | 5a5zC-5z5kA:undetectable |