SIMILAR PATTERNS OF AMINO ACIDS FOR 5A1R_A_STRA600_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aoc COAGULOGEN

(Tachypleus
tridentatus) 		PF02035
(Coagulin) 		4 PHE A  51
PHE A 159
PHE A  57
VAL A  34
 None
 1.05A 5a1rA-1aocA:
undetectable		 5a1rA-1aocA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ash HEMOGLOBIN (OXY)

(Ascaris suum) 		PF00042
(Globin) 		4 PHE A  34
ASP A  58
PHE A  60
PHE A  61
 None
None
HEM  A 301 ( 4.8A)
None
 0.92A 5a1rA-1ashA:
1.8		 5a1rA-1ashA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dml DNA POLYMERASE
PROCESSIVITY FACTOR

(Human
alphaherpesvirus
1) 		PF02282
(Herpes_UL42) 		4 PHE A 202
PHE A 221
PHE A 210
VAL A 188
 None
 1.01A 5a1rA-1dmlA:
0.0		 5a1rA-1dmlA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT

(Methanopyrus
kandleri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 PHE A 532
ASP A 524
PHE A 525
PHE A 523
 None
 1.13A 5a1rA-1e6vA:
0.0		 5a1rA-1e6vA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PHE A  44
PHE A 106
PHE A  68
VAL A 126
 None
 0.97A 5a1rA-1gycA:
0.0		 5a1rA-1gycA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hsl HISTIDINE-BINDING
PROTEIN

(Escherichia
coli) 		PF00497
(SBP_bac_3) 		4 PHE A 231
ASP A 232
PHE A 233
VAL A 163
 None
 1.07A 5a1rA-1hslA:
0.0		 5a1rA-1hslA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iom CITRATE SYNTHASE

(Thermus
thermophilus) 		PF00285
(Citrate_synt) 		4 PHE A 157
ASP A 175
PHE A  43
VAL A 335
 None
 1.09A 5a1rA-1iomA:
undetectable		 5a1rA-1iomA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PHE A  44
PHE A 106
PHE A  68
VAL A 126
 None
 0.92A 5a1rA-1kyaA:
0.0		 5a1rA-1kyaA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mq0 CYTIDINE DEAMINASE

(Homo sapiens) 		PF00383
(dCMP_cyt_deam_1) 		4 PHE A 109
ASP A  81
PHE A  82
VAL A  75
 None
 1.12A 5a1rA-1mq0A:
0.0		 5a1rA-1mq0A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 PHE A 529
ASP A 521
PHE A 522
PHE A 520
 None
 1.08A 5a1rA-1mroA:
0.0		 5a1rA-1mroA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi4 HYPOTHETICAL PROTEIN
YHBO

(Escherichia
coli) 		PF01965
(DJ-1_PfpI) 		4 PHE A  39
ASP A  36
PHE A  34
VAL A  73
 None
 1.06A 5a1rA-1oi4A:
undetectable		 5a1rA-1oi4A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn9 GLUTATHIONE
S-TRANSFERASE 1-6

(Anopheles
gambiae) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 ASP A 172
PHE A 173
PHE A 171
VAL A 134
 None
 1.09A 5a1rA-1pn9A:
undetectable		 5a1rA-1pn9A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pww LETHAL FACTOR

(Bacillus
anthracis) 		PF07737
(ATLF)
PF09156
(Anthrax-tox_M) 		4 PHE A 688
PHE A 737
PHE A 741
VAL A 692
 None
 1.17A 5a1rA-1pwwA:
undetectable		 5a1rA-1pwwA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 PHE A 150
ASP A 210
PHE A 216
VAL A 229
 None
 1.20A 5a1rA-1v7vA:
undetectable		 5a1rA-1v7vA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp2 PUTATIVE XANTHOSINE
TRIPHOSPHATE
PYROPHOSPHATASE/HAM1
PROTEIN HOMOLOG

(Thermotoga
maritima) 		PF01725
(Ham1p_like) 		4 ASP A 151
PHE A 154
PHE A 163
VAL A 134
 None
 1.12A 5a1rA-1vp2A:
undetectable		 5a1rA-1vp2A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpq HYPOTHETICAL PROTEIN
TM1631

(Thermotoga
maritima) 		PF01904
(DUF72) 		4 PHE A 190
ASP A 169
PHE A 192
VAL A 224
 None
 0.95A 5a1rA-1vpqA:
undetectable		 5a1rA-1vpqA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wc8 TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT3

(Mus musculus) 		PF04051
(TRAPP) 		4 ASP A 101
PHE A 167
PHE A  71
VAL A 146
 None
 1.13A 5a1rA-1wc8A:
undetectable		 5a1rA-1wc8A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wky ENDO-BETA-1,4-MANNAN
ASE

(Bacillus sp.
JAMB-602) 		PF00150
(Cellulase) 		4 ASP A  45
PHE A  51
PHE A  36
VAL A 113
 None
 1.20A 5a1rA-1wkyA:
undetectable		 5a1rA-1wkyA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztv HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF01904
(DUF72) 		4 PHE A 191
ASP A 168
PHE A 193
VAL A 229
 None
 1.11A 5a1rA-1ztvA:
undetectable		 5a1rA-1ztvA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica) 		PF13192
(Thioredoxin_3) 		4 PHE A 119
PHE A 181
PHE A 121
VAL A 195
 None
 0.95A 5a1rA-1zypA:
undetectable		 5a1rA-1zypA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeh FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M) 		4 PHE A 147
PHE A 243
PHE A 244
VAL A 151
 None
 1.20A 5a1rA-2aehA:
undetectable		 5a1rA-2aehA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		4 PHE A 443
ASP A 500
PHE A 501
VAL A 381
 None
 1.19A 5a1rA-2ahwA:
undetectable		 5a1rA-2ahwA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0d THIOREDOXIN
PEROXIDASE 2

(Plasmodium
falciparum) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 PHE A  74
ASP A  80
PHE A  81
VAL A 170
 None
 0.91A 5a1rA-2c0dA:
undetectable		 5a1rA-2c0dA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exr CYTOKININ
DEHYDROGENASE 7

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		4 PHE A 400
PHE A 255
PHE A 252
VAL A 414
 None
 1.12A 5a1rA-2exrA:
undetectable		 5a1rA-2exrA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fnu AMINOTRANSFERASE

(Helicobacter
pylori) 		PF01041
(DegT_DnrJ_EryC1) 		4 PHE A 264
PHE A 369
PHE A 270
VAL A 365
 None
 1.07A 5a1rA-2fnuA:
undetectable		 5a1rA-2fnuA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grm PRGX

(Enterococcus
faecalis) 		PF01381
(HTH_3) 		4 PHE A  96
ASP A  93
PHE A  92
VAL A 127
 None
 0.88A 5a1rA-2grmA:
undetectable		 5a1rA-2grmA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h3g BIOSYNTHETIC PROTEIN

(Bacillus
anthracis) 		PF03309
(Pan_kinase) 		4 PHE X  54
PHE X   3
PHE X  81
VAL X  43
 None
 1.04A 5a1rA-2h3gX:
undetectable		 5a1rA-2h3gX:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT

(Streptococcus
mutans) 		PF04223
(CitF) 		4 PHE A 424
ASP A 378
PHE A 381
VAL A 441
 None
 1.20A 5a1rA-2hj0A:
undetectable		 5a1rA-2hj0A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 PHE A 556
ASP A 405
PHE A 406
VAL A 515
 None
 1.20A 5a1rA-2hnhA:
2.0		 5a1rA-2hnhA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PHE A  44
PHE A 106
PHE A  68
VAL A 126
 None
 1.02A 5a1rA-2hzhA:
undetectable		 5a1rA-2hzhA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		4 PHE A 147
PHE A 243
PHE A 244
VAL A 151
 None
 1.17A 5a1rA-2j0jA:
undetectable		 5a1rA-2j0jA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1d DISHEVELED-ASSOCIATE
D ACTIVATOR OF
MORPHOGENESIS 1

(Homo sapiens) 		PF02181
(FH2) 		4 PHE G 960
PHE G 973
PHE G 972
VAL G 804
 None
 0.96A 5a1rA-2j1dG:
undetectable		 5a1rA-2j1dG:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j63 AP-ENDONUCLEASE

(Leishmania
major) 		PF03372
(Exo_endo_phos) 		4 PHE A 381
ASP A 411
PHE A 440
VAL A 391
 None
 1.19A 5a1rA-2j63A:
undetectable		 5a1rA-2j63A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mjp PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01725
(Ham1p_like) 		4 ASP A 152
PHE A 155
PHE A 164
VAL A 134
 ANP  A 500 (-3.5A)
None
None
None
 1.16A 5a1rA-2mjpA:
undetectable		 5a1rA-2mjpA:
17.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		4 PHE A 314
PHE A 460
PHE A 491
VAL A 456
 None
 1.17A 5a1rA-2pg6A:
35.7		 5a1rA-2pg6A:
30.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm0 BES

(Bacillus cereus) 		PF00756
(Esterase) 		4 PHE A  56
PHE A 178
PHE A 154
VAL A 258
 None
 1.17A 5a1rA-2qm0A:
undetectable		 5a1rA-2qm0A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qri H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN K-B ALPHA
CHAIN, BETA-2
MICROGLOBULIN,
OVALBUMIN-DERIVED
PEPTIDE

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 PHE A   5
ASP A  77
PHE A  74
VAL A  97
 None
 1.20A 5a1rA-2qriA:
undetectable		 5a1rA-2qriA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PHE A  44
PHE A 106
PHE A  68
VAL A 126
 None
 1.01A 5a1rA-2qt6A:
undetectable		 5a1rA-2qt6A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rff PUTATIVE
NUCLEOTIDYLTRANSFERA
SE

(Sulfolobus
solfataricus) 		PF01909
(NTP_transf_2) 		4 PHE A  56
PHE A  29
PHE A  58
VAL A  73
 None
 1.06A 5a1rA-2rffA:
undetectable		 5a1rA-2rffA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whl BETA-MANNANASE

(Salipaludibacillus
agaradhaerens) 		PF00150
(Cellulase) 		4 ASP A  14
PHE A  20
PHE A   5
VAL A  82
 None
 1.19A 5a1rA-2whlA:
undetectable		 5a1rA-2whlA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PHE A  44
PHE A 106
PHE A  68
VAL A 126
 None
 0.98A 5a1rA-2xybA:
undetectable		 5a1rA-2xybA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6e DISHEVELED-ASSOCIATE
D ACTIVATOR OF
MORPHOGENESIS 1

(Homo sapiens) 		PF02181
(FH2) 		4 PHE A 960
PHE A 973
PHE A 972
VAL A 804
 None
 1.07A 5a1rA-2z6eA:
undetectable		 5a1rA-2z6eA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5a HEMOGLOBIN V

(Tokunagayusurika
akamusi) 		PF00042
(Globin) 		4 PHE A 151
ASP A  84
PHE A  87
VAL A 139
 None
 1.03A 5a1rA-3a5aA:
undetectable		 5a1rA-3a5aA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 ASP A 794
PHE A 744
PHE A 798
VAL A 747
 None
 1.08A 5a1rA-3ahiA:
undetectable		 5a1rA-3ahiA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		4 PHE A1232
PHE A 631
PHE A1246
VAL A1251
 None
 1.21A 5a1rA-3av6A:
undetectable		 5a1rA-3av6A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		4 PHE A 496
PHE A 214
PHE A 213
VAL A  87
 None
 0.93A 5a1rA-3ayfA:
undetectable		 5a1rA-3ayfA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		4 PHE X 285
PHE X 234
PHE X 233
VAL X 249
 None
 1.00A 5a1rA-3e3bX:
undetectable		 5a1rA-3e3bX:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jug BETA-MANNANASE

(Bacillus sp.
N16-5) 		PF00150
(Cellulase) 		4 ASP A  45
PHE A  51
PHE A  36
VAL A 113
 None
 1.14A 5a1rA-3jugA:
undetectable		 5a1rA-3jugA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv4 PHD FINGER PROTEIN 8

(Homo sapiens) 		PF00628
(PHD)
PF02373
(JmjC) 		4 PHE A 361
ASP A 249
PHE A 250
VAL A 231
 None
FE2  A 450 ( 2.5A)
None
None
 1.13A 5a1rA-3kv4A:
undetectable		 5a1rA-3kv4A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzn GLUCARATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF13378
(MR_MLE_C) 		4 PHE A 223
ASP A 199
PHE A 197
PHE A 200
 None
ACT  A 452 (-3.6A)
None
None
 1.15A 5a1rA-3mznA:
undetectable		 5a1rA-3mznA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9o PUTATIVE
UNCHARACTERIZED
PROTEIN

(Caenorhabditis
elegans) 		PF02373
(JmjC) 		4 PHE A 613
ASP A 497
PHE A 498
VAL A 479
 None
FE2  A   1 ( 2.6A)
None
None
 1.19A 5a1rA-3n9oA:
undetectable		 5a1rA-3n9oA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyy PUTATIVE
GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM

([Ruminococcus]
gnavus) 		PF01551
(Peptidase_M23) 		4 PHE A  45
ASP A  44
PHE A  77
VAL A  39
 None
 1.14A 5a1rA-3nyyA:
undetectable		 5a1rA-3nyyA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PHE A  44
PHE A 106
PHE A  68
VAL A 126
 None
 1.02A 5a1rA-3pxlA:
undetectable		 5a1rA-3pxlA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rl2 HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, A-3 ALPHA
CHAIN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ASP A  74
PHE A   9
PHE A  22
VAL A  67
 None
 1.01A 5a1rA-3rl2A:
undetectable		 5a1rA-3rl2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v85 CYTH-LIKE
PHOSPHATASE

(Arabidopsis
thaliana) 		PF01928
(CYTH) 		4 ASP A 129
PHE A 127
PHE A 130
VAL A 121
 None
 1.17A 5a1rA-3v85A:
undetectable		 5a1rA-3v85A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PHE A  65
PHE A 127
PHE A  89
VAL A 147
 None
 0.96A 5a1rA-3x1bA:
undetectable		 5a1rA-3x1bA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az3 LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		4 PHE A  38
PHE A 133
PHE A 132
VAL A  50
 None
 1.21A 5a1rA-4az3A:
undetectable		 5a1rA-4az3A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bla MALTOSE-BINDING
PERIPLASMIC PROTEIN,
SUPPRESSOR OF FUSED
HOMOLOG

(Escherichia
coli;
Homo sapiens) 		PF05076
(SUFU)
PF12470
(SUFU_C)
PF13416
(SBP_bac_8) 		4 PHE A 456
PHE A 495
PHE A 458
VAL A 488
 None
 1.18A 5a1rA-4blaA:
2.1		 5a1rA-4blaA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f54 UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF13590
(DUF4136) 		4 PHE A  42
ASP A  44
PHE A  45
VAL A 173
 None
MLY  A  43 ( 4.7A)
MLY  A 161 ( 4.9A)
None
 1.14A 5a1rA-4f54A:
undetectable		 5a1rA-4f54A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fi9 SUN
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF07738
(Sad1_UNC) 		4 PHE A 679
PHE A 677
PHE A 665
VAL A 624
 None
 1.20A 5a1rA-4fi9A:
undetectable		 5a1rA-4fi9A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifs FACT COMPLEX SUBUNIT
SSRP1

(Homo sapiens) 		PF08512
(Rtt106) 		4 PHE A 391
PHE A 415
PHE A 379
VAL A 418
 None
 1.10A 5a1rA-4ifsA:
undetectable		 5a1rA-4ifsA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0e PROBABLE
3-HYDROXYACYL-COA
DEHYDROGENASE
F54C8.1

(Caenorhabditis
elegans) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 PHE A 293
PHE A 211
PHE A 210
VAL A 276
 None
 1.12A 5a1rA-4j0eA:
undetectable		 5a1rA-4j0eA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3b M1 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 PHE A 733
ASP A 744
PHE A 656
VAL A 654
 None
 1.16A 5a1rA-4j3bA:
undetectable		 5a1rA-4j3bA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Saccharomyces
cerevisiae) 		PF03200
(Glyco_hydro_63)
PF16923
(Glyco_hydro_63N) 		4 PHE A 269
ASP A 168
PHE A 271
VAL A 122
 None
 1.16A 5a1rA-4j5tA:
undetectable		 5a1rA-4j5tA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jd0 NUCLEOTIDYL
TRANSFERASE

(Thermotoga
maritima) 		PF00483
(NTP_transferase) 		4 PHE A 183
PHE A  89
PHE A  90
VAL A 194
 GOL  A 313 (-4.9A)
None
None
None
 1.18A 5a1rA-4jd0A:
undetectable		 5a1rA-4jd0A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PHE A  44
PHE A 106
PHE A  68
VAL A 126
 None
 0.97A 5a1rA-4jhvA:
undetectable		 5a1rA-4jhvA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmh SUPPRESSOR OF FUSED
HOMOLOG

(Homo sapiens) 		PF05076
(SUFU)
PF12470
(SUFU_C) 		4 PHE A 116
PHE A 155
PHE A 118
VAL A 148
 None
 1.21A 5a1rA-4kmhA:
undetectable		 5a1rA-4kmhA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgn CELLULOSE-BINDING,
FAMILY II

(Acidothermus
cellulolyticus) 		no annotation 4 PHE A 276
PHE A 248
PHE A 211
VAL A 278
 None
 1.18A 5a1rA-4lgnA:
undetectable		 5a1rA-4lgnA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsc CALCIUM UPTAKE
PROTEIN 1,
MITOCHONDRIAL

(Homo sapiens) 		PF13202
(EF-hand_5)
PF13833
(EF-hand_8) 		4 PHE A 299
PHE A 223
PHE A 296
VAL A 215
 None
 1.16A 5a1rA-4nscA:
undetectable		 5a1rA-4nscA:
22.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		5 PHE A 213
ASP A 217
PHE A 219
PHE A 220
VAL A 240
 2QH  A 602 (-4.2A)
None
None
None
None
 0.89A 5a1rA-4ny4A:
58.2		 5a1rA-4ny4A:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptf DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 PHE A 121
ASP A 123
PHE A 129
VAL A 267
 None
 1.10A 5a1rA-4ptfA:
undetectable		 5a1rA-4ptfA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C

(Zea mays) 		PF00171
(Aldedh) 		4 PHE A 458
PHE A 466
PHE A 460
VAL A 304
 PEG  A 610 (-4.0A)
None
PEG  A 610 (-4.2A)
CSO  A 303 ( 3.0A)
 1.08A 5a1rA-4pxlA:
undetectable		 5a1rA-4pxlA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		4 PHE A 100
ASP A  98
PHE A  58
VAL A  53
 None
 1.21A 5a1rA-4qnyA:
undetectable		 5a1rA-4qnyA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r55 CHROMATIN PROTEIN
CREN7

(Sulfolobus
solfataricus) 		PF11520
(Cren7) 		4 PHE A  36
ASP A  38
PHE A  45
VAL A  10
 None
 1.01A 5a1rA-4r55A:
undetectable		 5a1rA-4r55A:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlv ADP-RIBOSYLATING
TOXIN CARDS

(Mycoplasma
pneumoniae) 		PF02917
(Pertussis_S1) 		4 PHE A 474
ASP A 476
PHE A 483
VAL A 354
 None
 1.04A 5a1rA-4tlvA:
undetectable		 5a1rA-4tlvA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ASP A 516
PHE A 520
PHE A 521
VAL A  98
 None
 1.04A 5a1rA-4ud8A:
undetectable		 5a1rA-4ud8A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ue0 FIBER

(Bovine
atadenovirus D) 		no annotation 4 PHE A 429
ASP A 431
PHE A 432
VAL A 462
 None
 1.02A 5a1rA-4ue0A:
undetectable		 5a1rA-4ue0A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		4 PHE A1229
PHE A 628
PHE A1243
VAL A1248
 None
 1.18A 5a1rA-4wxxA:
undetectable		 5a1rA-4wxxA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhf NA-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
NQRC

(Shewanella
oneidensis) 		PF04205
(FMN_bind) 		4 PHE A 239
PHE A 247
PHE A 248
VAL A 138
 None
 1.11A 5a1rA-4xhfA:
undetectable		 5a1rA-4xhfA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE

(Bacillus cereus) 		PF05547
(Peptidase_M6) 		4 PHE A 381
PHE A 203
PHE A 219
VAL A 166
 None
 1.20A 5a1rA-4yu5A:
undetectable		 5a1rA-4yu5A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0z AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 PHE A 225
PHE A 121
PHE A 122
VAL A 247
 None
HS8  A 252 ( 4.6A)
None
None
 1.20A 5a1rA-4z0zA:
undetectable		 5a1rA-4z0zA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z11 AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
PF12143
(PPO1_KFDV) 		4 PHE A 225
PHE A 121
PHE A 122
VAL A 247
 None
 1.19A 5a1rA-4z11A:
undetectable		 5a1rA-4z11A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a11 THIOCYANATE FORMING
PROTEIN

(Thlaspi arvense) 		PF01344
(Kelch_1) 		4 ASP A  56
PHE A  57
PHE A  55
VAL A  12
 None
None
None
IOD  A1351 ( 4.0A)
 1.16A 5a1rA-5a11A:
undetectable		 5a1rA-5a11A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq5 INSERTION SEQUENCE
IS5376 PUTATIVE
ATP-BINDING PROTEIN

(Geobacillus
stearothermophilus) 		PF01695
(IstB_IS21) 		4 ASP A  74
PHE A  75
PHE A  73
VAL A  81
 None
None
ADP  A 301 (-2.9A)
None
 0.97A 5a1rA-5bq5A:
undetectable		 5a1rA-5bq5A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PHE A  44
PHE A 106
PHE A  68
VAL A 126
 None
 1.01A 5a1rA-5ehfA:
undetectable		 5a1rA-5ehfA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 PHE A 556
ASP A 405
PHE A 406
VAL A 515
 None
 0.96A 5a1rA-5fkuA:
2.0		 5a1rA-5fkuA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gq0 EPITHIOSPECIFIER
PROTEIN

(Arabidopsis
thaliana) 		no annotation 4 ASP B  56
PHE B  57
PHE B  55
VAL B  12
 None
 1.18A 5a1rA-5gq0B:
undetectable		 5a1rA-5gq0B:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL

(Aspergillus
nidulans) 		PF00579
(tRNA-synt_1b) 		4 PHE A 421
PHE A 373
PHE A 374
VAL A 139
 None
 0.86A 5a1rA-5ihxA:
undetectable		 5a1rA-5ihxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D

(Homo sapiens) 		PF04858
(TH1)
no annotation 		4 PHE B 553
PHE A 163
PHE B 549
VAL B 537
 None
 0.86A 5a1rA-5l3xB:
undetectable		 5a1rA-5l3xB:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 PHE A 223
PHE A 150
PHE A 225
VAL A 160
 None
 1.19A 5a1rA-5l6fA:
0.1		 5a1rA-5l6fA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqc VP3

(Black queen
cell virus) 		no annotation 4 PHE C 242
ASP C  56
PHE C  55
VAL C 244
 None
 0.97A 5a1rA-5mqcC:
undetectable		 5a1rA-5mqcC:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanotorris
formicicus) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 PHE A 531
ASP A 523
PHE A 524
PHE A 522
 None
 1.10A 5a1rA-5n28A:
undetectable		 5a1rA-5n28A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oki DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A 121
ASP A 123
PHE A 129
VAL A 267
 None
 1.14A 5a1rA-5okiA:
undetectable		 5a1rA-5okiA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvn PARAQUAT-INDUCIBLE
PROTEIN B

(Escherichia
coli) 		PF02470
(MlaD) 		4 PHE A 268
PHE A 250
PHE A 218
VAL A 212
 None
 1.04A 5a1rA-5uvnA:
undetectable		 5a1rA-5uvnA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc8 SIAD

(Mannheimia
haemolytica) 		no annotation 4 ASP M 202
PHE M 204
PHE M 201
VAL M 148
 None
 1.17A 5a1rA-5wc8M:
undetectable		 5a1rA-5wc8M:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 4 PHE A  67
PHE A 155
PHE A 124
VAL A  45
 SAH  A 701 (-4.6A)
None
None
None
 1.05A 5a1rA-5wp4A:
1.0		 5a1rA-5wp4A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 4 PHE A  67
PHE A 155
PHE A 124
VAL A  45
 SAH  A 502 (-4.6A)
None
None
None
 1.09A 5a1rA-5wp5A:
undetectable		 5a1rA-5wp5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xap PROTEIN TRANSLOCASE
SUBUNIT SECD

(Deinococcus
radiodurans) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 PHE A 648
ASP A 502
PHE A 503
VAL A 653
 None
 1.01A 5a1rA-5xapA:
1.4		 5a1rA-5xapA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4m -

(-) 		no annotation 4 PHE A  48
ASP A  88
PHE A  89
VAL A  40
 None
 0.82A 5a1rA-5y4mA:
undetectable		 5a1rA-5y4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykn PROBABLE
LYSINE-SPECIFIC
DEMETHYLASE JMJ14

(Arabidopsis
thaliana) 		no annotation 4 ASP A 186
PHE A 404
PHE A 182
VAL A 299
 None
 1.15A 5a1rA-5yknA:
undetectable		 5a1rA-5yknA:
10.40