SIMILAR PATTERNS OF AMINO ACIDS FOR 5A1I_A_SAMA405
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1awb | MYO-INOSITOLMONOPHOSPHATASE (Homo sapiens) |
PF00459(Inositol_P) | 4 | PRO A 91ASP A 90SER A 165ASP A 47 | CA A 1 ( 4.9A) CA A 278 (-2.7A)IPD A 281 ( 3.8A)None | 1.02A | 5a1iA-1awbA:undetectable | 5a1iA-1awbA:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f4h | BETA-GALACTOSIDASE (Escherichiacoli) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N)PF16353(DUF4981) | 4 | HIS A 395PRO A 396PHE A 209ASP A 144 | None | 1.28A | 5a1iA-1f4hA:undetectable | 5a1iA-1f4hA:16.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fue | FLAVODOXIN (Helicobacterpylori) |
PF00258(Flavodoxin_1) | 4 | ASP A 140SER A 126PHE A 96ASP A 90 | None | 1.30A | 5a1iA-1fueA:undetectable | 5a1iA-1fueA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gqj | ALPHA-D-GLUCURONIDASE (Cellvibriojaponicus) |
PF03648(Glyco_hydro_67N)PF07477(Glyco_hydro_67C)PF07488(Glyco_hydro_67M) | 4 | HIS A 521ASP A 365SER A 291PHE A 327 | XYP A1719 (-4.1A)XYP A1719 (-3.3A)NoneNone | 1.26A | 5a1iA-1gqjA:undetectable | 5a1iA-1gqjA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hcy | ARTHROPODANHEMOCYANIN (Panulirusinterruptus) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 4 | HIS A 16ASP A 19SER A 535PHE A 536 | None | 1.28A | 5a1iA-1hcyA:undetectable | 5a1iA-1hcyA:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iip | CYCLOPHILIN 40 (Bos taurus) |
PF00160(Pro_isomerase)PF13176(TPR_7) | 4 | PRO A 194ASP A 196PHE A 233ASP A 200 | None | 1.13A | 5a1iA-1iipA:undetectable | 5a1iA-1iipA:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ltz | PHENYLALANINE-4-HYDROXYLASE (Chromobacteriumviolaceum) |
PF00351(Biopterin_H) | 4 | HIS A 138PRO A 134ASP A 139PHE A 116 | FE A 400 (-3.3A)NoneHBI A 500 ( 4.9A)None | 0.97A | 5a1iA-1ltzA:undetectable | 5a1iA-1ltzA:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1psz | PROTEIN (SURFACEANTIGEN PSAA) (Streptococcuspneumoniae) |
PF01297(ZnuA) | 4 | HIS A 67PRO A 66ASP A 65ASP A 280 | ZN A1000 ( 3.2A)NoneNone ZN A1000 ( 2.2A) | 1.25A | 5a1iA-1pszA:undetectable | 5a1iA-1pszA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q44 | STEROIDSULFOTRANSFERASE (Arabidopsisthaliana) |
PF00685(Sulfotransfer_1) | 4 | PRO A 204SER A 320PHE A 317ASP A 207 | None | 1.29A | 5a1iA-1q44A:undetectable | 5a1iA-1q44A:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5d | P450 EPOXIDASE (Sorangiumcellulosum) |
PF00067(p450) | 4 | HIS A 400PRO A 401ASP A 192SER A 201 | None | 1.19A | 5a1iA-1q5dA:undetectable | 5a1iA-1q5dA:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r8g | HYPOTHETICAL PROTEINYBDK (Escherichiacoli) |
PF04107(GCS2) | 4 | HIS A 300PRO A 299ASP A 298ASP A 276 | None | 1.24A | 5a1iA-1r8gA:undetectable | 5a1iA-1r8gA:24.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1raj | GENOME POLYPROTEIN (Enterovirus C) |
PF00680(RdRP_1) | 4 | HIS A 423PRO A 390PHE A 461ASP A 215 | None | 1.13A | 5a1iA-1rajA:undetectable | 5a1iA-1rajA:23.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rdr | POLIOVIRUS 3DPOLYMERASE (Enterovirus C) |
PF00680(RdRP_1) | 4 | HIS A 423PRO A 390PHE A 461ASP A 215 | None | 1.13A | 5a1iA-1rdrA:undetectable | 5a1iA-1rdrA:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uwy | CARBOXYPEPTIDASE M (Homo sapiens) |
PF00246(Peptidase_M14)PF13620(CarboxypepD_reg) | 4 | HIS A 322SER A 197PHE A 183ASP A 201 | None | 1.24A | 5a1iA-1uwyA:undetectable | 5a1iA-1uwyA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wg8 | PREDICTEDS-ADENOSYLMETHIONINE-DEPENDENTMETHYLTRANSFERASE (Thermusthermophilus) |
PF01795(Methyltransf_5) | 4 | HIS A 36ASP A 96SER A 274PHE A 234 | SAM A3142 (-3.9A)SAM A3142 (-3.5A)NoneNone | 1.22A | 5a1iA-1wg8A:undetectable | 5a1iA-1wg8A:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xr5 | GENOME POLYPROTEIN (Rhinovirus B) |
PF00680(RdRP_1) | 4 | HIS A 422PRO A 389PHE A 460ASP A 215 | None | 1.12A | 5a1iA-1xr5A:undetectable | 5a1iA-1xr5A:22.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xrc | S-ADENOSYLMETHIONINESYNTHETASE (Escherichiacoli) |
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C) | 6 | HIS A 14PRO A 15ASP A 163LYS A 165PHE A 230ASP A 238 | None | 0.51A | 5a1iA-1xrcA:54.0 | 5a1iA-1xrcA:54.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yb4 | TARTRONICSEMIALDEHYDEREDUCTASE (Salmonellaenterica) |
PF03446(NAD_binding_2)PF14833(NAD_binding_11) | 4 | ASP A 116LYS A 101SER A 245ASP A 164 | None | 0.99A | 5a1iA-1yb4A:undetectable | 5a1iA-1yb4A:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yq2 | BETA-GALACTOSIDASE (Arthrobactersp. C2-2) |
PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N)PF16353(DUF4981) | 4 | HIS A 373PRO A 374PHE A 209ASP A 144 | None | 1.28A | 5a1iA-1yq2A:undetectable | 5a1iA-1yq2A:17.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bji | INOSITOL-1(OR4)-MONOPHOSPHATASE (Bos taurus) |
PF00459(Inositol_P) | 4 | PRO A1091ASP A1090SER A1165ASP A1047 | MG A2277 ( 4.8A) MG A2278 ( 2.5A)NoneNone | 1.09A | 5a1iA-2bjiA:undetectable | 5a1iA-2bjiA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cfz | SDS HYDROLASE SDSA1 (Pseudomonasaeruginosa) |
PF00753(Lactamase_B)PF14863(Alkyl_sulf_dimr)PF14864(Alkyl_sulf_C) | 4 | HIS A 169ASP A 138SER A 249ASP A 173 | ZN A1002 (-3.2A)NoneNone ZN A1001 ( 2.5A) | 1.18A | 5a1iA-2cfzA:undetectable | 5a1iA-2cfzA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gzb | KUNITZ-TYPEPROTEINASE INHIBITORBBCI (Bauhiniabauhinioides) |
PF00197(Kunitz_legume) | 4 | HIS A 49PRO A 48ASP A 47ASP A 142 | None | 1.03A | 5a1iA-2gzbA:undetectable | 5a1iA-2gzbA:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ijd | PICORNAIN 3C,RNA-DIRECTED RNAPOLYMERASE (Enterovirus C) |
PF00548(Peptidase_C3)PF00680(RdRP_1) | 4 | HIS 1 606PRO 1 573PHE 1 644ASP 1 398 | None | 1.12A | 5a1iA-2ijd1:undetectable | 5a1iA-2ijd1:22.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2obv | S-ADENOSYLMETHIONINESYNTHETASE ISOFORMTYPE-1 (Homo sapiens) |
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C) | 7 | HIS A 29PRO A 30ASP A 179LYS A 181SER A 247PHE A 250ASP A 258 | SAM A 501 (-3.6A)SAM A 501 (-4.2A)SAM A 501 (-2.7A)SAM A 501 (-3.9A)SAM A 501 (-2.8A)SAM A 501 (-3.4A)SAM A 501 (-3.6A) | 0.19A | 5a1iA-2obvA:64.9 | 5a1iA-2obvA:85.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p82 | CYSTEINE PROTEASEATG4A (Homo sapiens) |
PF03416(Peptidase_C54) | 4 | HIS A 281PRO A 280ASP A 279PHE A 277 | None | 1.31A | 5a1iA-2p82A:undetectable | 5a1iA-2p82A:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qfq | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Escherichiacoli) |
PF00275(EPSP_synthase) | 4 | HIS A 385LYS A 411SER A 25ASP A 313 | FMT A 601 (-4.3A)FMT A 602 (-2.8A)NoneS3P A 701 ( 2.8A) | 1.14A | 5a1iA-2qfqA:undetectable | 5a1iA-2qfqA:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xio | PUTATIVEDEOXYRIBONUCLEASETATDN1 (Homo sapiens) |
PF01026(TatD_DNase) | 4 | HIS A 77PRO A 78SER A 199ASP A 116 | None | 0.96A | 5a1iA-2xioA:undetectable | 5a1iA-2xioA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xy9 | ANGIOTENSIN-CONVERTING ENZYME (Homo sapiens) |
PF01401(Peptidase_M2) | 4 | HIS A 383ASP A 415SER A 461PHE A 527 | ZN A1628 ( 3.2A)3ES A1635 ( 3.9A)None3ES A1635 (-4.6A) | 1.19A | 5a1iA-2xy9A:undetectable | 5a1iA-2xy9A:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z4t | BETA-GALACTOSIDEALPHA-2,6-SIALYLTRANSFERASE (Photobacteriumsp. JT-ISH-224) |
PF11477(PM0188) | 4 | HIS A 123ASP A 122SER A 430ASP A 232 | LBT A2000 ( 4.0A) MG A5001 (-4.4A)C5P A1427 (-2.7A)LBT A2000 ( 2.9A) | 0.71A | 5a1iA-2z4tA:undetectable | 5a1iA-2z4tA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c9h | ABC TRANSPORTER,SUBSTRATE BINDINGPROTEIN (Agrobacteriumfabrum) |
PF13416(SBP_bac_8) | 4 | PRO A 254ASP A 256SER A 200PHE A 195 | None | 1.15A | 5a1iA-3c9hA:undetectable | 5a1iA-3c9hA:22.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d45 | POLY(A)-SPECIFICRIBONUCLEASE PARN (Mus musculus) |
PF01424(R3H)PF04857(CAF1)PF08675(RNA_bind) | 4 | HIS A 439PRO A 481ASP A 438LYS A 436 | None | 0.92A | 5a1iA-3d45A:undetectable | 5a1iA-3d45A:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dl1 | PUTATIVEMETAL-DEPENDENTHYDROLASE (Klebsiellapneumoniae) |
PF06167(Peptidase_M90) | 4 | PRO A 97ASP A 134SER A 142PHE A 144 | None | 1.29A | 5a1iA-3dl1A:undetectable | 5a1iA-3dl1A:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dwb | ENDOTHELIN-CONVERTING ENZYME 1 (Homo sapiens) |
PF01431(Peptidase_M13)PF05649(Peptidase_M13_N) | 4 | HIS A 732PRO A 731ASP A 730SER A 150 | RDF A 817 (-3.6A)RDF A 817 (-4.7A)RDF A 817 ( 4.8A)None | 1.26A | 5a1iA-3dwbA:undetectable | 5a1iA-3dwbA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3er6 | PUTATIVETRANSCRIPTIONALREGULATOR PROTEIN (Vibrioparahaemolyticus) |
PF01965(DJ-1_PfpI) | 4 | HIS A 135PRO A 169ASP A 115SER A 89 | None | 1.10A | 5a1iA-3er6A:undetectable | 5a1iA-3er6A:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g3o | VACUOLAR TRANSPORTERCHAPERONE 2 (Saccharomycescerevisiae) |
PF09359(VTC) | 4 | ASP A 284SER A 521PHE A 523ASP A 293 | NoneSO4 A1001 (-2.5A)NoneNone | 0.93A | 5a1iA-3g3oA:undetectable | 5a1iA-3g3oA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hf8 | TRYPTOPHAN5-HYDROXYLASE 1 (Homo sapiens) |
PF00351(Biopterin_H) | 4 | HIS A 272PRO A 268SER A 290PHE A 250 | FE A 400 ( 3.3A)ML0 A 401 (-3.6A)NoneNone | 1.31A | 5a1iA-3hf8A:undetectable | 5a1iA-3hf8A:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hh8 | METAL ABCTRANSPORTERSUBSTRATE-BINDINGLIPOPROTEIN (Streptococcuspyogenes) |
PF01297(ZnuA) | 4 | HIS A 67PRO A 66ASP A 65ASP A 280 | FE A 401 (-3.3A)NoneNone FE A 401 (-2.1A) | 1.19A | 5a1iA-3hh8A:undetectable | 5a1iA-3hh8A:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ij6 | UNCHARACTERIZEDMETAL-DEPENDENTHYDROLASE (Lactobacillusacidophilus) |
PF04909(Amidohydro_2) | 4 | HIS A 225ASP A 228LYS A 224ASP A 191 | None | 1.00A | 5a1iA-3ij6A:undetectable | 5a1iA-3ij6A:21.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3iml | S-ADENOSYLMETHIONINESYNTHETASE (Burkholderiapseudomallei) |
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C) | 5 | HIS A 16PRO A 17ASP A 167LYS A 169PHE A 234 | None | 0.25A | 5a1iA-3imlA:52.2 | 5a1iA-3imlA:53.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3iml | S-ADENOSYLMETHIONINESYNTHETASE (Burkholderiapseudomallei) |
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C) | 4 | HIS A 16PRO A 17LYS A 169ASP A 242 | None | 0.90A | 5a1iA-3imlA:52.2 | 5a1iA-3imlA:53.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m1r | FORMIMIDOYLGLUTAMASE (Bacillussubtilis) |
PF00491(Arginase) | 4 | HIS A 152ASP A 154SER A 47ASP A 242 | CA A 322 (-3.4A) CA A 323 ( 2.5A)None CA A 322 ( 2.9A) | 1.05A | 5a1iA-3m1rA:undetectable | 5a1iA-3m1rA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mpg | DIHYDROOROTASE (Bacillusanthracis) |
PF01979(Amidohydro_1) | 4 | ASP A 57SER A 394PHE A 327ASP A 304 | NoneNoneNone ZN A 429 (-2.9A) | 1.19A | 5a1iA-3mpgA:undetectable | 5a1iA-3mpgA:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n6n | RNA-DEPENDENT RNAPOLYMERASE (Enterovirus A) |
PF00680(RdRP_1) | 4 | HIS A 424PRO A 391PHE A 462ASP A 215 | None | 1.18A | 5a1iA-3n6nA:undetectable | 5a1iA-3n6nA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nvs | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Vibrio cholerae) |
PF00275(EPSP_synthase) | 4 | HIS A 386LYS A 412SER A 25ASP A 314 | GPJ A 429 (-4.3A)GPJ A 429 (-2.9A)NoneSKM A 428 (-2.7A) | 1.13A | 5a1iA-3nvsA:undetectable | 5a1iA-3nvsA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p2c | PUTATIVE GLYCOSYLHYDROLASE (Bacteroidesovatus) |
PF06824(Glyco_hydro_125) | 4 | PRO A 401SER A 283PHE A 339ASP A 273 | None | 1.32A | 5a1iA-3p2cA:undetectable | 5a1iA-3p2cA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qp3 | TITIN (Homo sapiens) |
PF07679(I-set) | 4 | HIS A 72ASP A 75SER A 52ASP A 70 | None | 1.23A | 5a1iA-3qp3A:undetectable | 5a1iA-3qp3A:13.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3rv2 | S-ADENOSYLMETHIONINESYNTHASE (Mycobacteriummarinum) |
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C) | 6 | HIS A 17PRO A 18ASP A 179LYS A 181PHE A 251ASP A 259 | NoneNoneNoneNoneNone CA A 404 (-3.4A) | 0.70A | 5a1iA-3rv2A:49.3 | 5a1iA-3rv2A:53.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rys | ADENOSINE DEAMINASE1 (Paenarthrobacteraurescens) |
PF00962(A_deaminase) | 4 | HIS A 21ASP A 281SER A 61PHE A 62 | ADE A 345 ( 3.2A)ADE A 345 (-2.8A)NoneNone | 1.21A | 5a1iA-3rysA:undetectable | 5a1iA-3rysA:23.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3so4 | METHIONINE-ADENOSYLTRANSFERASE (Entamoebahistolytica) |
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C) | 7 | HIS A 16PRO A 17ASP A 166LYS A 168SER A 234PHE A 237ASP A 245 | NoneNoneNoneACT A 400 ( 4.9A)NoneNoneNone | 0.67A | 5a1iA-3so4A:55.6 | 5a1iA-3so4A:61.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tc9 | HYPOTHETICALHYDROLASE (Bacteroidesthetaiotaomicron) |
PF01833(TIG) | 4 | PRO A 173ASP A 172SER A 241PHE A 243 | None | 1.16A | 5a1iA-3tc9A:undetectable | 5a1iA-3tc9A:23.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tsm | INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE (Brucellaabortus) |
PF00218(IGPS) | 4 | PRO A 99ASP A 97SER A 148PHE A 124 | None | 1.12A | 5a1iA-3tsmA:undetectable | 5a1iA-3tsmA:23.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v8u | TRANSFERRINBINDING-PROTEIN B (Neisseriameningitidis) |
PF01298(TbpB_B_D)PF17483(TbpB_C)PF17484(TbpB_A) | 4 | HIS A 143ASP A 161PHE A 217ASP A 221 | None | 0.84A | 5a1iA-3v8uA:undetectable | 5a1iA-3v8uA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zre | THIOL PEROXIDASE (Yersiniapseudotuberculosis) |
PF08534(Redoxin) | 4 | ASP A 86SER A 64PHE A 53ASP A 57 | None | 1.32A | 5a1iA-3zreA:undetectable | 5a1iA-3zreA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a1o | BIFUNCTIONAL PURINEBIOSYNTHESIS PROTEINPURH (Mycobacteriumtuberculosis) |
PF01808(AICARFT_IMPCHas)PF02142(MGS) | 4 | PRO A 154ASP A 153SER A 114ASP A 19 | None | 1.16A | 5a1iA-4a1oA:undetectable | 5a1iA-4a1oA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4as5 | INOSITOLMONOPHOSPHATASE 1 (Mus musculus) |
PF00459(Inositol_P) | 4 | PRO A 91ASP A 90SER A 165ASP A 47 | MG A 501 ( 4.9A) MG A 502 (-2.4A)NoneNone | 1.14A | 5a1iA-4as5A:undetectable | 5a1iA-4as5A:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b56 | ECTONUCLEOTIDEPYROPHOSPHATASE/PHOSPHODIESTERASE FAMILYMEMBER 1 (Mus musculus) |
PF01033(Somatomedin_B)PF01223(Endonuclease_NS)PF01663(Phosphodiest) | 4 | PRO A 240SER A 274PHE A 270ASP A 258 | None | 1.26A | 5a1iA-4b56A:undetectable | 5a1iA-4b56A:18.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e1o | HISTIDINEDECARBOXYLASE (Homo sapiens) |
PF00282(Pyridoxal_deC) | 4 | HIS A 76ASP A 463PHE A 448ASP A 459 | None | 1.20A | 5a1iA-4e1oA:undetectable | 5a1iA-4e1oA:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g3j | STEROL14-ALPHA-DEMETHYLASE (Trypanosomabrucei) |
PF00067(p450) | 4 | HIS A 84PRO A 83ASP A 82ASP A 390 | None | 1.26A | 5a1iA-4g3jA:undetectable | 5a1iA-4g3jA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gfh | DNA TOPOISOMERASE 2 (Saccharomycescerevisiae) |
PF00204(DNA_gyraseB)PF00521(DNA_topoisoIV)PF01751(Toprim)PF02518(HATPase_c)PF16898(TOPRIM_C) | 4 | HIS A 533ASP A 530SER A 740ASP A 687 | None | 1.18A | 5a1iA-4gfhA:undetectable | 5a1iA-4gfhA:15.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hjw | URACIL-5-CARBOXYLATEDECARBOXYLASE (Metarhiziumanisopliae) |
PF04909(Amidohydro_2) | 4 | HIS A 251ASP A 297PHE A 193ASP A 323 | NoneNoneNone ZN A 401 (-2.8A) | 1.12A | 5a1iA-4hjwA:undetectable | 5a1iA-4hjwA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hpv | S-ADENOSYLMETHIONINESYNTHASE (Sulfolobussolfataricus) |
PF01941(AdoMet_Synthase) | 4 | HIS A 29PRO A 30ASP A 199LYS A 201 | None | 0.37A | 5a1iA-4hpvA:27.8 | 5a1iA-4hpvA:24.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hpv | S-ADENOSYLMETHIONINESYNTHASE (Sulfolobussolfataricus) |
PF01941(AdoMet_Synthase) | 4 | PRO A 30ASP A 199LYS A 201ASP A 282 | None | 0.96A | 5a1iA-4hpvA:27.8 | 5a1iA-4hpvA:24.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hw6 | HYPOTHETICALPROTEIN, IPT/TIGDOMAIN PROTEIN (Bacteroidesovatus) |
PF01833(TIG) | 4 | PRO A 180ASP A 179SER A 248PHE A 250 | None | 0.93A | 5a1iA-4hw6A:undetectable | 5a1iA-4hw6A:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4igm | 2-AMINO-3-CARBOXYMUCONATE-6-SEMIALDEHYDEDECARBOXYLASE (Homo sapiens) |
PF04909(Amidohydro_2) | 4 | HIS A 224ASP A 265PHE A 172ASP A 291 | NoneNoneNone ZN A 401 (-3.0A) | 0.97A | 5a1iA-4igmA:undetectable | 5a1iA-4igmA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l4q | S-ADENOSYLMETHIONINESYNTHASE (Thermococcuskodakarensis) |
PF01941(AdoMet_Synthase) | 4 | HIS A 33PRO A 34ASP A 201ASP A 283 | None | 0.86A | 5a1iA-4l4qA:28.3 | 5a1iA-4l4qA:25.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l4q | S-ADENOSYLMETHIONINESYNTHASE (Thermococcuskodakarensis) |
PF01941(AdoMet_Synthase) | 4 | HIS A 33PRO A 34ASP A 201LYS A 203 | None | 0.54A | 5a1iA-4l4qA:28.3 | 5a1iA-4l4qA:25.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4le5 | S-ADENOSYLMETHIONINESYNTHETASE (Campylobacterjejuni) |
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C) | 5 | HIS A 13PRO A 14ASP A 168LYS A 170ASP A 250 | None | 0.64A | 5a1iA-4le5A:49.4 | 5a1iA-4le5A:38.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nhb | TRAP DICARBOXYLATETRANSPORTER-DCTPSUBUNIT (Desulfovibriodesulfuricans) |
PF03480(DctP) | 4 | PRO A 212ASP A 215SER A 70PHE A 194 | NoneNoneNoneG3P A 414 (-4.7A) | 1.25A | 5a1iA-4nhbA:undetectable | 5a1iA-4nhbA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nz0 | GENOME POLYPROTEIN (Cardiovirus A) |
PF00680(RdRP_1) | 4 | HIS A 425PRO A 393PHE A 459ASP A 215 | None | 1.14A | 5a1iA-4nz0A:undetectable | 5a1iA-4nz0A:21.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4odj | S-ADENOSYLMETHIONINESYNTHASE (Cryptosporidiumhominis) |
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C) | 7 | HIS A 34PRO A 35ASP A 187LYS A 189SER A 255PHE A 258ASP A 266 | SAM A 500 ( 3.8A)SAM A 500 (-4.3A)SAM A 500 (-2.8A)3PO A 501 ( 2.7A)SAM A 500 (-2.7A)SAM A 500 (-3.5A)SAM A 500 (-3.3A) | 0.25A | 5a1iA-4odjA:60.2 | 5a1iA-4odjA:56.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oua | LATENT FORM OF PPO4TYROSINASE (Agaricusbisporus) |
PF00264(Tyrosinase) | 4 | PRO B 176ASP B 175SER B 49PHE B 51 | None | 1.19A | 5a1iA-4ouaB:undetectable | 5a1iA-4ouaB:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oua | PROTEOLYTICALLYACTIVATED FORM OFPPO4 TYROSINASE (Agaricusbisporus) |
PF00264(Tyrosinase) | 4 | PRO A 176ASP A 175SER A 49PHE A 51 | None | 1.18A | 5a1iA-4ouaA:undetectable | 5a1iA-4ouaA:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r40 | PROTEIN TOLB (Yersinia pestis) |
PF04052(TolB_N)PF07676(PD40) | 4 | HIS A 180PRO A 201SER A 392PHE A 423 | None | 1.28A | 5a1iA-4r40A:undetectable | 5a1iA-4r40A:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r84 | SIALYLTRANSFERASE0160 (Photobacteriumdamselae) |
PF11477(PM0188) | 4 | HIS A 120ASP A 119SER A 426ASP A 229 | NoneNoneCSF A 501 ( 3.8A)None | 0.93A | 5a1iA-4r84A:undetectable | 5a1iA-4r84A:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s17 | GLUTAMINE SYNTHETASE (Bifidobacteriumadolescentis) |
PF00120(Gln-synt_C)PF03951(Gln-synt_N) | 4 | HIS A 238ASP A 241PHE A 378ASP A 75 | None | 1.08A | 5a1iA-4s17A:undetectable | 5a1iA-4s17A:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v06 | TRYPTOPHAN5-HYDROXYLASE 2 (Homo sapiens) |
PF00351(Biopterin_H) | 4 | HIS A 318PRO A 314SER A 336PHE A 296 | FE A1491 ( 3.5A)IMD A 600 ( 4.7A)NoneIMD A 600 (-4.7A) | 1.24A | 5a1iA-4v06A:undetectable | 5a1iA-4v06A:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v39 | SIALYLTRANSFERASE (Pasteurelladagmatis) |
PF11477(PM0188) | 4 | HIS A 7ASP A 6SER A 309ASP A 114 | None | 0.91A | 5a1iA-4v39A:undetectable | 5a1iA-4v39A:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xdt | FAD:PROTEIN FMNTRANSFERASE (Treponemapallidum) |
PF02424(ApbE) | 4 | HIS A 220ASP A 218PHE A 336ASP A 271 | None | 0.85A | 5a1iA-4xdtA:undetectable | 5a1iA-4xdtA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zpd | RNA-DIRECTED RNAPOLYMERASE (Enterovirus B) |
PF00680(RdRP_1) | 4 | HIS A 424PRO A 391PHE A 462ASP A 215 | None | 1.15A | 5a1iA-4zpdA:undetectable | 5a1iA-4zpdA:23.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5a1i | S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2 (Homo sapiens) |
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C) | 7 | HIS A 29PRO A 30ASP A 179LYS A 181SER A 247PHE A 250ASP A 258 | SAM A 405 ( 3.6A)SAM A 405 (-4.0A)ADN A 407 (-2.8A)PPK A 400 ( 2.6A)ADN A 407 (-2.7A)SAM A 405 (-3.4A) K A 403 ( 3.0A) | 0.01A | 5a1iA-5a1iA:68.5 | 5a1iA-5a1iA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5buv | PUTATIVE EPIMERASE (Yersiniaenterocolitica) |
PF00908(dTDP_sugar_isom) | 4 | HIS A 139PRO A 141ASP A 144SER A 164 | CYT A 203 (-3.7A)NoneNoneNone | 1.25A | 5a1iA-5buvA:undetectable | 5a1iA-5buvA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dmy | BETA-GALACTOSIDASE (Bifidobacteriumbifidum) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 4 | HIS A 830PRO A 615LYS A 618SER A 540 | None | 1.29A | 5a1iA-5dmyA:undetectable | 5a1iA-5dmyA:17.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5h9u | S-ADENOSYLMETHIONINESYNTHASE (Thermusthermophilus) |
no annotation | 6 | HIS C 16PRO C 17ASP C 175SER C 240PHE C 243ASP C 251 | None | 0.79A | 5a1iA-5h9uC:54.7 | 5a1iA-5h9uC:50.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5h9u | S-ADENOSYLMETHIONINESYNTHASE (Thermusthermophilus) |
no annotation | 4 | HIS C 16PRO C 17LYS C 177ASP C 251 | None | 0.99A | 5a1iA-5h9uC:54.7 | 5a1iA-5h9uC:50.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jk6 | PHENYLALANINE-4-HYDROXYLASE (Dictyosteliumdiscoideum) |
PF00351(Biopterin_H) | 4 | HIS A 273PRO A 269SER A 291PHE A 251 | FE A 502 (-3.2A)NoneNoneNone | 1.33A | 5a1iA-5jk6A:undetectable | 5a1iA-5jk6A:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jvk | UNCHARACTERIZEDPROTEIN (Bacteroidescellulosilyticus) |
no annotation | 4 | HIS A 137SER A 188PHE A 184ASP A 162 | GOL A 654 (-4.3A)NoneNoneGOL A 654 (-2.9A) | 1.14A | 5a1iA-5jvkA:undetectable | 5a1iA-5jvkA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l01 | TRYPTOPHAN5-HYDROXYLASE 1 (Homo sapiens) |
PF00351(Biopterin_H) | 4 | HIS A 272PRO A 268SER A 290PHE A 250 | FE A 501 ( 3.2A)6Z4 A 502 (-3.8A)NoneNone | 1.31A | 5a1iA-5l01A:undetectable | 5a1iA-5l01A:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l9w | ACETOPHENONECARBOXYLASE DELTASUBUNIT (Aromatoleumaromaticum) |
PF02538(Hydantoinase_B) | 4 | HIS A 148PRO A 125ASP A 126SER A 364 | HG A 701 (-3.5A)None HG A 701 (-2.0A)None | 1.29A | 5a1iA-5l9wA:undetectable | 5a1iA-5l9wA:20.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t8t | S-ADENOSYLMETHIONINESYNTHASE (Neisseriagonorrhoeae) |
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C) | 5 | HIS A 15PRO A 16ASP A 166PHE A 235ASP A 243 | None | 0.65A | 5a1iA-5t8tA:55.6 | 5a1iA-5t8tA:56.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t98 | GLYCOSIDE HYDROLASE (Bacteroidesuniformis) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 4 | PRO A 559ASP A 560SER A 703ASP A 549 | None | 1.03A | 5a1iA-5t98A:undetectable | 5a1iA-5t98A:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tdx | ANCESTRALHYDROXYNITRILE LYASE1 (syntheticconstruct) |
no annotation | 4 | PRO A 212LYS A 208SER A 240ASP A 205 | None | 1.04A | 5a1iA-5tdxA:undetectable | 5a1iA-5tdxA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tnv | AP ENDONUCLEASE,FAMILY PROTEIN 2 (Mycolicibacteriumsmegmatis) |
PF01261(AP_endonuc_2) | 4 | PRO A 51ASP A 50SER A 171PHE A 230 | None | 1.21A | 5a1iA-5tnvA:undetectable | 5a1iA-5tnvA:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v44 | SACSIN (Homo sapiens) |
no annotation | 4 | HIS A 218ASP A 216SER A 145ASP A 202 | None | 1.33A | 5a1iA-5v44A:undetectable | 5a1iA-5v44A:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wlz | DNA REPAIR PROTEINXRCC4,MYOSIN-7 (Homo sapiens) |
no annotation | 4 | HIS C 40ASP C 38SER C 89PHE C 88 | None | 1.28A | 5a1iA-5wlzC:undetectable | 5a1iA-5wlzC:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xe0 | GENOME POLYPROTEIN (Enterovirus D) |
PF00680(RdRP_1) | 4 | HIS A 419PRO A 386PHE A 457ASP A 211 | None | 1.19A | 5a1iA-5xe0A:undetectable | 5a1iA-5xe0A:23.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ane | POLY(ETHYLENETEREPHTHALATE)HYDROLASE (Ideonellasakaiensis) |
no annotation | 4 | PRO A 93ASP A 159SER A 166PHE A 164 | None | 1.33A | 5a1iA-6aneA:undetectable | 5a1iA-6aneA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c7y | TYROSINE-PROTEINKINASE JAK1SUPPRESSOR OFCYTOKINE SIGNALING 1 (Homo sapiens;Gallus gallus) |
no annotationno annotation | 4 | HIS B 54PRO A1044SER A 963ASP A1003 | NoneNoneADP A1201 (-3.3A) MG A1203 (-4.7A) | 1.28A | 5a1iA-6c7yB:undetectable | 5a1iA-6c7yB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c87 | RAB GDP DISSOCIATIONINHIBITOR ALPHA (Naegleriafowleri) |
no annotation | 4 | HIS A 188ASP A 334SER A 415ASP A 195 | None | 1.18A | 5a1iA-6c87A:undetectable | 5a1iA-6c87A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6etz | BETA-GALACTOSIDASE (Arthrobactersp. 32cB) |
no annotation | 4 | HIS A 372PRO A 373PHE A 215ASP A 150 | None | 1.26A | 5a1iA-6etzA:undetectable | 5a1iA-6etzA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f2t | - (-) |
no annotation | 4 | PRO A 208SER A 242PHE A 238ASP A 226 | None | 1.31A | 5a1iA-6f2tA:undetectable | 5a1iA-6f2tA:undetectable |