SIMILAR PATTERNS OF AMINO ACIDS FOR 5A1I_A_SAMA405

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1awb MYO-INOSITOL
MONOPHOSPHATASE


(Homo sapiens)
PF00459
(Inositol_P)
4 PRO A  91
ASP A  90
SER A 165
ASP A  47
CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
1.02A 5a1iA-1awbA:
undetectable
5a1iA-1awbA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981)
4 HIS A 395
PRO A 396
PHE A 209
ASP A 144
None
1.28A 5a1iA-1f4hA:
undetectable
5a1iA-1f4hA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fue FLAVODOXIN

(Helicobacter
pylori)
PF00258
(Flavodoxin_1)
4 ASP A 140
SER A 126
PHE A  96
ASP A  90
None
1.30A 5a1iA-1fueA:
undetectable
5a1iA-1fueA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E


(Cellvibrio
japonicus)
PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M)
4 HIS A 521
ASP A 365
SER A 291
PHE A 327
XYP  A1719 (-4.1A)
XYP  A1719 (-3.3A)
None
None
1.26A 5a1iA-1gqjA:
undetectable
5a1iA-1gqjA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN


(Panulirus
interruptus)
PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C)
4 HIS A  16
ASP A  19
SER A 535
PHE A 536
None
1.28A 5a1iA-1hcyA:
undetectable
5a1iA-1hcyA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iip CYCLOPHILIN 40

(Bos taurus)
PF00160
(Pro_isomerase)
PF13176
(TPR_7)
4 PRO A 194
ASP A 196
PHE A 233
ASP A 200
None
1.13A 5a1iA-1iipA:
undetectable
5a1iA-1iipA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltz PHENYLALANINE-4-HYDR
OXYLASE


(Chromobacterium
violaceum)
PF00351
(Biopterin_H)
4 HIS A 138
PRO A 134
ASP A 139
PHE A 116
FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
0.97A 5a1iA-1ltzA:
undetectable
5a1iA-1ltzA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1psz PROTEIN (SURFACE
ANTIGEN PSAA)


(Streptococcus
pneumoniae)
PF01297
(ZnuA)
4 HIS A  67
PRO A  66
ASP A  65
ASP A 280
ZN  A1000 ( 3.2A)
None
None
ZN  A1000 ( 2.2A)
1.25A 5a1iA-1pszA:
undetectable
5a1iA-1pszA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q44 STEROID
SULFOTRANSFERASE


(Arabidopsis
thaliana)
PF00685
(Sulfotransfer_1)
4 PRO A 204
SER A 320
PHE A 317
ASP A 207
None
1.29A 5a1iA-1q44A:
undetectable
5a1iA-1q44A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5d P450 EPOXIDASE

(Sorangium
cellulosum)
PF00067
(p450)
4 HIS A 400
PRO A 401
ASP A 192
SER A 201
None
1.19A 5a1iA-1q5dA:
undetectable
5a1iA-1q5dA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8g HYPOTHETICAL PROTEIN
YBDK


(Escherichia
coli)
PF04107
(GCS2)
4 HIS A 300
PRO A 299
ASP A 298
ASP A 276
None
1.24A 5a1iA-1r8gA:
undetectable
5a1iA-1r8gA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1raj GENOME POLYPROTEIN

(Enterovirus C)
PF00680
(RdRP_1)
4 HIS A 423
PRO A 390
PHE A 461
ASP A 215
None
1.13A 5a1iA-1rajA:
undetectable
5a1iA-1rajA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rdr POLIOVIRUS 3D
POLYMERASE


(Enterovirus C)
PF00680
(RdRP_1)
4 HIS A 423
PRO A 390
PHE A 461
ASP A 215
None
1.13A 5a1iA-1rdrA:
undetectable
5a1iA-1rdrA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwy CARBOXYPEPTIDASE M

(Homo sapiens)
PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg)
4 HIS A 322
SER A 197
PHE A 183
ASP A 201
None
1.24A 5a1iA-1uwyA:
undetectable
5a1iA-1uwyA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE


(Thermus
thermophilus)
PF01795
(Methyltransf_5)
4 HIS A  36
ASP A  96
SER A 274
PHE A 234
SAM  A3142 (-3.9A)
SAM  A3142 (-3.5A)
None
None
1.22A 5a1iA-1wg8A:
undetectable
5a1iA-1wg8A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B)
PF00680
(RdRP_1)
4 HIS A 422
PRO A 389
PHE A 460
ASP A 215
None
1.12A 5a1iA-1xr5A:
undetectable
5a1iA-1xr5A:
22.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xrc S-ADENOSYLMETHIONINE
SYNTHETASE


(Escherichia
coli)
PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C)
6 HIS A  14
PRO A  15
ASP A 163
LYS A 165
PHE A 230
ASP A 238
None
0.51A 5a1iA-1xrcA:
54.0
5a1iA-1xrcA:
54.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE


(Salmonella
enterica)
PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11)
4 ASP A 116
LYS A 101
SER A 245
ASP A 164
None
0.99A 5a1iA-1yb4A:
undetectable
5a1iA-1yb4A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981)
4 HIS A 373
PRO A 374
PHE A 209
ASP A 144
None
1.28A 5a1iA-1yq2A:
undetectable
5a1iA-1yq2A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bji INOSITOL-1(OR
4)-MONOPHOSPHATASE


(Bos taurus)
PF00459
(Inositol_P)
4 PRO A1091
ASP A1090
SER A1165
ASP A1047
MG  A2277 ( 4.8A)
MG  A2278 ( 2.5A)
None
None
1.09A 5a1iA-2bjiA:
undetectable
5a1iA-2bjiA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfz SDS HYDROLASE SDSA1

(Pseudomonas
aeruginosa)
PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C)
4 HIS A 169
ASP A 138
SER A 249
ASP A 173
ZN  A1002 (-3.2A)
None
None
ZN  A1001 ( 2.5A)
1.18A 5a1iA-2cfzA:
undetectable
5a1iA-2cfzA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzb KUNITZ-TYPE
PROTEINASE INHIBITOR
BBCI


(Bauhinia
bauhinioides)
PF00197
(Kunitz_legume)
4 HIS A  49
PRO A  48
ASP A  47
ASP A 142
None
1.03A 5a1iA-2gzbA:
undetectable
5a1iA-2gzbA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE


(Enterovirus C)
PF00548
(Peptidase_C3)
PF00680
(RdRP_1)
4 HIS 1 606
PRO 1 573
PHE 1 644
ASP 1 398
None
1.12A 5a1iA-2ijd1:
undetectable
5a1iA-2ijd1:
22.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2obv S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1


(Homo sapiens)
PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C)
7 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 247
PHE A 250
ASP A 258
SAM  A 501 (-3.6A)
SAM  A 501 (-4.2A)
SAM  A 501 (-2.7A)
SAM  A 501 (-3.9A)
SAM  A 501 (-2.8A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.6A)
0.19A 5a1iA-2obvA:
64.9
5a1iA-2obvA:
85.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p82 CYSTEINE PROTEASE
ATG4A


(Homo sapiens)
PF03416
(Peptidase_C54)
4 HIS A 281
PRO A 280
ASP A 279
PHE A 277
None
1.31A 5a1iA-2p82A:
undetectable
5a1iA-2p82A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE


(Escherichia
coli)
PF00275
(EPSP_synthase)
4 HIS A 385
LYS A 411
SER A  25
ASP A 313
FMT  A 601 (-4.3A)
FMT  A 602 (-2.8A)
None
S3P  A 701 ( 2.8A)
1.14A 5a1iA-2qfqA:
undetectable
5a1iA-2qfqA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1


(Homo sapiens)
PF01026
(TatD_DNase)
4 HIS A  77
PRO A  78
SER A 199
ASP A 116
None
0.96A 5a1iA-2xioA:
undetectable
5a1iA-2xioA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME


(Homo sapiens)
PF01401
(Peptidase_M2)
4 HIS A 383
ASP A 415
SER A 461
PHE A 527
ZN  A1628 ( 3.2A)
3ES  A1635 ( 3.9A)
None
3ES  A1635 (-4.6A)
1.19A 5a1iA-2xy9A:
undetectable
5a1iA-2xy9A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE


(Photobacterium
sp. JT-ISH-224)
PF11477
(PM0188)
4 HIS A 123
ASP A 122
SER A 430
ASP A 232
LBT  A2000 ( 4.0A)
MG  A5001 (-4.4A)
C5P  A1427 (-2.7A)
LBT  A2000 ( 2.9A)
0.71A 5a1iA-2z4tA:
undetectable
5a1iA-2z4tA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9h ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN


(Agrobacterium
fabrum)
PF13416
(SBP_bac_8)
4 PRO A 254
ASP A 256
SER A 200
PHE A 195
None
1.15A 5a1iA-3c9hA:
undetectable
5a1iA-3c9hA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d45 POLY(A)-SPECIFIC
RIBONUCLEASE PARN


(Mus musculus)
PF01424
(R3H)
PF04857
(CAF1)
PF08675
(RNA_bind)
4 HIS A 439
PRO A 481
ASP A 438
LYS A 436
None
0.92A 5a1iA-3d45A:
undetectable
5a1iA-3d45A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE


(Klebsiella
pneumoniae)
PF06167
(Peptidase_M90)
4 PRO A  97
ASP A 134
SER A 142
PHE A 144
None
1.29A 5a1iA-3dl1A:
undetectable
5a1iA-3dl1A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1


(Homo sapiens)
PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N)
4 HIS A 732
PRO A 731
ASP A 730
SER A 150
RDF  A 817 (-3.6A)
RDF  A 817 (-4.7A)
RDF  A 817 ( 4.8A)
None
1.26A 5a1iA-3dwbA:
undetectable
5a1iA-3dwbA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3er6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR PROTEIN


(Vibrio
parahaemolyticus)
PF01965
(DJ-1_PfpI)
4 HIS A 135
PRO A 169
ASP A 115
SER A  89
None
1.10A 5a1iA-3er6A:
undetectable
5a1iA-3er6A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3o VACUOLAR TRANSPORTER
CHAPERONE 2


(Saccharomyces
cerevisiae)
PF09359
(VTC)
4 ASP A 284
SER A 521
PHE A 523
ASP A 293
None
SO4  A1001 (-2.5A)
None
None
0.93A 5a1iA-3g3oA:
undetectable
5a1iA-3g3oA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hf8 TRYPTOPHAN
5-HYDROXYLASE 1


(Homo sapiens)
PF00351
(Biopterin_H)
4 HIS A 272
PRO A 268
SER A 290
PHE A 250
FE  A 400 ( 3.3A)
ML0  A 401 (-3.6A)
None
None
1.31A 5a1iA-3hf8A:
undetectable
5a1iA-3hf8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hh8 METAL ABC
TRANSPORTER
SUBSTRATE-BINDING
LIPOPROTEIN


(Streptococcus
pyogenes)
PF01297
(ZnuA)
4 HIS A  67
PRO A  66
ASP A  65
ASP A 280
FE  A 401 (-3.3A)
None
None
FE  A 401 (-2.1A)
1.19A 5a1iA-3hh8A:
undetectable
5a1iA-3hh8A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij6 UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE


(Lactobacillus
acidophilus)
PF04909
(Amidohydro_2)
4 HIS A 225
ASP A 228
LYS A 224
ASP A 191
None
1.00A 5a1iA-3ij6A:
undetectable
5a1iA-3ij6A:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE


(Burkholderia
pseudomallei)
PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C)
5 HIS A  16
PRO A  17
ASP A 167
LYS A 169
PHE A 234
None
0.25A 5a1iA-3imlA:
52.2
5a1iA-3imlA:
53.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE


(Burkholderia
pseudomallei)
PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C)
4 HIS A  16
PRO A  17
LYS A 169
ASP A 242
None
0.90A 5a1iA-3imlA:
52.2
5a1iA-3imlA:
53.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1r FORMIMIDOYLGLUTAMASE

(Bacillus
subtilis)
PF00491
(Arginase)
4 HIS A 152
ASP A 154
SER A  47
ASP A 242
CA  A 322 (-3.4A)
CA  A 323 ( 2.5A)
None
CA  A 322 ( 2.9A)
1.05A 5a1iA-3m1rA:
undetectable
5a1iA-3m1rA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpg DIHYDROOROTASE

(Bacillus
anthracis)
PF01979
(Amidohydro_1)
4 ASP A  57
SER A 394
PHE A 327
ASP A 304
None
None
None
ZN  A 429 (-2.9A)
1.19A 5a1iA-3mpgA:
undetectable
5a1iA-3mpgA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6n RNA-DEPENDENT RNA
POLYMERASE


(Enterovirus A)
PF00680
(RdRP_1)
4 HIS A 424
PRO A 391
PHE A 462
ASP A 215
None
1.18A 5a1iA-3n6nA:
undetectable
5a1iA-3n6nA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE


(Vibrio cholerae)
PF00275
(EPSP_synthase)
4 HIS A 386
LYS A 412
SER A  25
ASP A 314
GPJ  A 429 (-4.3A)
GPJ  A 429 (-2.9A)
None
SKM  A 428 (-2.7A)
1.13A 5a1iA-3nvsA:
undetectable
5a1iA-3nvsA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2c PUTATIVE GLYCOSYL
HYDROLASE


(Bacteroides
ovatus)
PF06824
(Glyco_hydro_125)
4 PRO A 401
SER A 283
PHE A 339
ASP A 273
None
1.32A 5a1iA-3p2cA:
undetectable
5a1iA-3p2cA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp3 TITIN

(Homo sapiens)
PF07679
(I-set)
4 HIS A  72
ASP A  75
SER A  52
ASP A  70
None
1.23A 5a1iA-3qp3A:
undetectable
5a1iA-3qp3A:
13.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE


(Mycobacterium
marinum)
PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C)
6 HIS A  17
PRO A  18
ASP A 179
LYS A 181
PHE A 251
ASP A 259
None
None
None
None
None
CA  A 404 (-3.4A)
0.70A 5a1iA-3rv2A:
49.3
5a1iA-3rv2A:
53.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rys ADENOSINE DEAMINASE
1


(Paenarthrobacter
aurescens)
PF00962
(A_deaminase)
4 HIS A  21
ASP A 281
SER A  61
PHE A  62
ADE  A 345 ( 3.2A)
ADE  A 345 (-2.8A)
None
None
1.21A 5a1iA-3rysA:
undetectable
5a1iA-3rysA:
23.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3so4 METHIONINE-ADENOSYLT
RANSFERASE


(Entamoeba
histolytica)
PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C)
7 HIS A  16
PRO A  17
ASP A 166
LYS A 168
SER A 234
PHE A 237
ASP A 245
None
None
None
ACT  A 400 ( 4.9A)
None
None
None
0.67A 5a1iA-3so4A:
55.6
5a1iA-3so4A:
61.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc9 HYPOTHETICAL
HYDROLASE


(Bacteroides
thetaiotaomicron)
PF01833
(TIG)
4 PRO A 173
ASP A 172
SER A 241
PHE A 243
None
1.16A 5a1iA-3tc9A:
undetectable
5a1iA-3tc9A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE


(Brucella
abortus)
PF00218
(IGPS)
4 PRO A  99
ASP A  97
SER A 148
PHE A 124
None
1.12A 5a1iA-3tsmA:
undetectable
5a1iA-3tsmA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8u TRANSFERRIN
BINDING-PROTEIN B


(Neisseria
meningitidis)
PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A)
4 HIS A 143
ASP A 161
PHE A 217
ASP A 221
None
0.84A 5a1iA-3v8uA:
undetectable
5a1iA-3v8uA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zre THIOL PEROXIDASE

(Yersinia
pseudotuberculosis)
PF08534
(Redoxin)
4 ASP A  86
SER A  64
PHE A  53
ASP A  57
None
1.32A 5a1iA-3zreA:
undetectable
5a1iA-3zreA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH


(Mycobacterium
tuberculosis)
PF01808
(AICARFT_IMPCHas)
PF02142
(MGS)
4 PRO A 154
ASP A 153
SER A 114
ASP A  19
None
1.16A 5a1iA-4a1oA:
undetectable
5a1iA-4a1oA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4as5 INOSITOL
MONOPHOSPHATASE 1


(Mus musculus)
PF00459
(Inositol_P)
4 PRO A  91
ASP A  90
SER A 165
ASP A  47
MG  A 501 ( 4.9A)
MG  A 502 (-2.4A)
None
None
1.14A 5a1iA-4as5A:
undetectable
5a1iA-4as5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1


(Mus musculus)
PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest)
4 PRO A 240
SER A 274
PHE A 270
ASP A 258
None
1.26A 5a1iA-4b56A:
undetectable
5a1iA-4b56A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1o HISTIDINE
DECARBOXYLASE


(Homo sapiens)
PF00282
(Pyridoxal_deC)
4 HIS A  76
ASP A 463
PHE A 448
ASP A 459
None
1.20A 5a1iA-4e1oA:
undetectable
5a1iA-4e1oA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE


(Trypanosoma
brucei)
PF00067
(p450)
4 HIS A  84
PRO A  83
ASP A  82
ASP A 390
None
1.26A 5a1iA-4g3jA:
undetectable
5a1iA-4g3jA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae)
PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C)
4 HIS A 533
ASP A 530
SER A 740
ASP A 687
None
1.18A 5a1iA-4gfhA:
undetectable
5a1iA-4gfhA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE


(Metarhizium
anisopliae)
PF04909
(Amidohydro_2)
4 HIS A 251
ASP A 297
PHE A 193
ASP A 323
None
None
None
ZN  A 401 (-2.8A)
1.12A 5a1iA-4hjwA:
undetectable
5a1iA-4hjwA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE


(Sulfolobus
solfataricus)
PF01941
(AdoMet_Synthase)
4 HIS A  29
PRO A  30
ASP A 199
LYS A 201
None
0.37A 5a1iA-4hpvA:
27.8
5a1iA-4hpvA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE


(Sulfolobus
solfataricus)
PF01941
(AdoMet_Synthase)
4 PRO A  30
ASP A 199
LYS A 201
ASP A 282
None
0.96A 5a1iA-4hpvA:
27.8
5a1iA-4hpvA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN


(Bacteroides
ovatus)
PF01833
(TIG)
4 PRO A 180
ASP A 179
SER A 248
PHE A 250
None
0.93A 5a1iA-4hw6A:
undetectable
5a1iA-4hw6A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE


(Homo sapiens)
PF04909
(Amidohydro_2)
4 HIS A 224
ASP A 265
PHE A 172
ASP A 291
None
None
None
ZN  A 401 (-3.0A)
0.97A 5a1iA-4igmA:
undetectable
5a1iA-4igmA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4q S-ADENOSYLMETHIONINE
SYNTHASE


(Thermococcus
kodakarensis)
PF01941
(AdoMet_Synthase)
4 HIS A  33
PRO A  34
ASP A 201
ASP A 283
None
0.86A 5a1iA-4l4qA:
28.3
5a1iA-4l4qA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4q S-ADENOSYLMETHIONINE
SYNTHASE


(Thermococcus
kodakarensis)
PF01941
(AdoMet_Synthase)
4 HIS A  33
PRO A  34
ASP A 201
LYS A 203
None
0.54A 5a1iA-4l4qA:
28.3
5a1iA-4l4qA:
25.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4le5 S-ADENOSYLMETHIONINE
SYNTHETASE


(Campylobacter
jejuni)
PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C)
5 HIS A  13
PRO A  14
ASP A 168
LYS A 170
ASP A 250
None
0.64A 5a1iA-4le5A:
49.4
5a1iA-4le5A:
38.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT


(Desulfovibrio
desulfuricans)
PF03480
(DctP)
4 PRO A 212
ASP A 215
SER A  70
PHE A 194
None
None
None
G3P  A 414 (-4.7A)
1.25A 5a1iA-4nhbA:
undetectable
5a1iA-4nhbA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A)
PF00680
(RdRP_1)
4 HIS A 425
PRO A 393
PHE A 459
ASP A 215
None
1.14A 5a1iA-4nz0A:
undetectable
5a1iA-4nz0A:
21.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4odj S-ADENOSYLMETHIONINE
SYNTHASE


(Cryptosporidium
hominis)
PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C)
7 HIS A  34
PRO A  35
ASP A 187
LYS A 189
SER A 255
PHE A 258
ASP A 266
SAM  A 500 ( 3.8A)
SAM  A 500 (-4.3A)
SAM  A 500 (-2.8A)
3PO  A 501 ( 2.7A)
SAM  A 500 (-2.7A)
SAM  A 500 (-3.5A)
SAM  A 500 (-3.3A)
0.25A 5a1iA-4odjA:
60.2
5a1iA-4odjA:
56.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua LATENT FORM OF PPO4
TYROSINASE


(Agaricus
bisporus)
PF00264
(Tyrosinase)
4 PRO B 176
ASP B 175
SER B  49
PHE B  51
None
1.19A 5a1iA-4ouaB:
undetectable
5a1iA-4ouaB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE


(Agaricus
bisporus)
PF00264
(Tyrosinase)
4 PRO A 176
ASP A 175
SER A  49
PHE A  51
None
1.18A 5a1iA-4ouaA:
undetectable
5a1iA-4ouaA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r40 PROTEIN TOLB

(Yersinia pestis)
PF04052
(TolB_N)
PF07676
(PD40)
4 HIS A 180
PRO A 201
SER A 392
PHE A 423
None
1.28A 5a1iA-4r40A:
undetectable
5a1iA-4r40A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r84 SIALYLTRANSFERASE
0160


(Photobacterium
damselae)
PF11477
(PM0188)
4 HIS A 120
ASP A 119
SER A 426
ASP A 229
None
None
CSF  A 501 ( 3.8A)
None
0.93A 5a1iA-4r84A:
undetectable
5a1iA-4r84A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s17 GLUTAMINE SYNTHETASE

(Bifidobacterium
adolescentis)
PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N)
4 HIS A 238
ASP A 241
PHE A 378
ASP A  75
None
1.08A 5a1iA-4s17A:
undetectable
5a1iA-4s17A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v06 TRYPTOPHAN
5-HYDROXYLASE 2


(Homo sapiens)
PF00351
(Biopterin_H)
4 HIS A 318
PRO A 314
SER A 336
PHE A 296
FE  A1491 ( 3.5A)
IMD  A 600 ( 4.7A)
None
IMD  A 600 (-4.7A)
1.24A 5a1iA-4v06A:
undetectable
5a1iA-4v06A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v39 SIALYLTRANSFERASE

(Pasteurella
dagmatis)
PF11477
(PM0188)
4 HIS A   7
ASP A   6
SER A 309
ASP A 114
None
0.91A 5a1iA-4v39A:
undetectable
5a1iA-4v39A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdt FAD:PROTEIN FMN
TRANSFERASE


(Treponema
pallidum)
PF02424
(ApbE)
4 HIS A 220
ASP A 218
PHE A 336
ASP A 271
None
0.85A 5a1iA-4xdtA:
undetectable
5a1iA-4xdtA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpd RNA-DIRECTED RNA
POLYMERASE


(Enterovirus B)
PF00680
(RdRP_1)
4 HIS A 424
PRO A 391
PHE A 462
ASP A 215
None
1.15A 5a1iA-4zpdA:
undetectable
5a1iA-4zpdA:
23.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2


(Homo sapiens)
PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C)
7 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 247
PHE A 250
ASP A 258
SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 (-2.7A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
0.01A 5a1iA-5a1iA:
68.5
5a1iA-5a1iA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5buv PUTATIVE EPIMERASE

(Yersinia
enterocolitica)
PF00908
(dTDP_sugar_isom)
4 HIS A 139
PRO A 141
ASP A 144
SER A 164
CYT  A 203 (-3.7A)
None
None
None
1.25A 5a1iA-5buvA:
undetectable
5a1iA-5buvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982)
4 HIS A 830
PRO A 615
LYS A 618
SER A 540
None
1.29A 5a1iA-5dmyA:
undetectable
5a1iA-5dmyA:
17.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h9u S-ADENOSYLMETHIONINE
SYNTHASE


(Thermus
thermophilus)
no annotation 6 HIS C  16
PRO C  17
ASP C 175
SER C 240
PHE C 243
ASP C 251
None
0.79A 5a1iA-5h9uC:
54.7
5a1iA-5h9uC:
50.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h9u S-ADENOSYLMETHIONINE
SYNTHASE


(Thermus
thermophilus)
no annotation 4 HIS C  16
PRO C  17
LYS C 177
ASP C 251
None
0.99A 5a1iA-5h9uC:
54.7
5a1iA-5h9uC:
50.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jk6 PHENYLALANINE-4-HYDR
OXYLASE


(Dictyostelium
discoideum)
PF00351
(Biopterin_H)
4 HIS A 273
PRO A 269
SER A 291
PHE A 251
FE  A 502 (-3.2A)
None
None
None
1.33A 5a1iA-5jk6A:
undetectable
5a1iA-5jk6A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvk UNCHARACTERIZED
PROTEIN


(Bacteroides
cellulosilyticus)
no annotation 4 HIS A 137
SER A 188
PHE A 184
ASP A 162
GOL  A 654 (-4.3A)
None
None
GOL  A 654 (-2.9A)
1.14A 5a1iA-5jvkA:
undetectable
5a1iA-5jvkA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l01 TRYPTOPHAN
5-HYDROXYLASE 1


(Homo sapiens)
PF00351
(Biopterin_H)
4 HIS A 272
PRO A 268
SER A 290
PHE A 250
FE  A 501 ( 3.2A)
6Z4  A 502 (-3.8A)
None
None
1.31A 5a1iA-5l01A:
undetectable
5a1iA-5l01A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT


(Aromatoleum
aromaticum)
PF02538
(Hydantoinase_B)
4 HIS A 148
PRO A 125
ASP A 126
SER A 364
HG  A 701 (-3.5A)
None
HG  A 701 (-2.0A)
None
1.29A 5a1iA-5l9wA:
undetectable
5a1iA-5l9wA:
20.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE


(Neisseria
gonorrhoeae)
PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C)
5 HIS A  15
PRO A  16
ASP A 166
PHE A 235
ASP A 243
None
0.65A 5a1iA-5t8tA:
55.6
5a1iA-5t8tA:
56.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t98 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982)
4 PRO A 559
ASP A 560
SER A 703
ASP A 549
None
1.03A 5a1iA-5t98A:
undetectable
5a1iA-5t98A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1


(synthetic
construct)
no annotation 4 PRO A 212
LYS A 208
SER A 240
ASP A 205
None
1.04A 5a1iA-5tdxA:
undetectable
5a1iA-5tdxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2


(Mycolicibacterium
smegmatis)
PF01261
(AP_endonuc_2)
4 PRO A  51
ASP A  50
SER A 171
PHE A 230
None
1.21A 5a1iA-5tnvA:
undetectable
5a1iA-5tnvA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v44 SACSIN

(Homo sapiens)
no annotation 4 HIS A 218
ASP A 216
SER A 145
ASP A 202
None
1.33A 5a1iA-5v44A:
undetectable
5a1iA-5v44A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlz DNA REPAIR PROTEIN
XRCC4,MYOSIN-7


(Homo sapiens)
no annotation 4 HIS C  40
ASP C  38
SER C  89
PHE C  88
None
1.28A 5a1iA-5wlzC:
undetectable
5a1iA-5wlzC:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe0 GENOME POLYPROTEIN

(Enterovirus D)
PF00680
(RdRP_1)
4 HIS A 419
PRO A 386
PHE A 457
ASP A 211
None
1.19A 5a1iA-5xe0A:
undetectable
5a1iA-5xe0A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ane POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE


(Ideonella
sakaiensis)
no annotation 4 PRO A  93
ASP A 159
SER A 166
PHE A 164
None
1.33A 5a1iA-6aneA:
undetectable
5a1iA-6aneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1
SUPPRESSOR OF
CYTOKINE SIGNALING 1


(Homo sapiens;
Gallus gallus)
no annotation
no annotation
4 HIS B  54
PRO A1044
SER A 963
ASP A1003
None
None
ADP  A1201 (-3.3A)
MG  A1203 (-4.7A)
1.28A 5a1iA-6c7yB:
undetectable
5a1iA-6c7yB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA


(Naegleria
fowleri)
no annotation 4 HIS A 188
ASP A 334
SER A 415
ASP A 195
None
1.18A 5a1iA-6c87A:
undetectable
5a1iA-6c87A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB)
no annotation 4 HIS A 372
PRO A 373
PHE A 215
ASP A 150
None
1.26A 5a1iA-6etzA:
undetectable
5a1iA-6etzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-)
no annotation 4 PRO A 208
SER A 242
PHE A 238
ASP A 226
None
1.31A 5a1iA-6f2tA:
undetectable
5a1iA-6f2tA:
undetectable