SIMILAR PATTERNS OF AMINO ACIDS FOR 5A06_F_SORF1342

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE

(Bacillus
subtilis) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 ARG X  88
HIS X 202
ALA X 151
GLU X 111
 NAD  X 900 (-3.5A)
MN  X 700 ( 3.4A)
NAD  X 900 ( 4.8A)
G6P  X 902 ( 2.7A)
 1.10A 5a06A-1u8xX:
7.5
5a06F-1u8xX:
7.2		 5a06A-1u8xX:
21.43
5a06F-1u8xX:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E

(Pyrococcus
abyssi;
Pyrococcus
abyssi) 		PF00710
(Asparaginase)
PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD) 		4 ARG C  48
HIS A 258
ALA A 264
GLU C  90
 None
 1.28A 5a06A-1zq1C:
0.6
5a06F-1zq1C:
0.2		 5a06A-1zq1C:
21.88
5a06F-1zq1C:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp2 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ARG A 269
HIS A 393
ALA A 113
GLU A 396
 None
 1.29A 5a06A-2yp2A:
0.0
5a06F-2yp2A:
0.2		 5a06A-2yp2A:
20.00
5a06F-2yp2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk3 PROTEIN AF-9 HOMOLOG

(Saccharomyces
cerevisiae) 		PF03366
(YEATS) 		4 ARG A  75
HIS A  39
ALA A  35
GLU A  86
 None
 1.32A 5a06A-3fk3A:
0.0
5a06F-3fk3A:
0.0		 5a06A-3fk3A:
16.87
5a06F-3fk3A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izq ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF08938
(HBS1_N) 		4 ARG 1 564
HIS 1 584
ALA 1 583
GLU 1 509
 None
 1.41A 5a06A-3izq1:
4.2
5a06F-3izq1:
4.2		 5a06A-3izq1:
19.37
5a06F-3izq1:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9r PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Mycobacteroides
abscessus) 		PF01259
(SAICAR_synt) 		4 ARG A  34
HIS A  10
ALA A  12
GLU A  18
 ARG  A  34 ( 0.6A)
HIS  A  10 ( 1.0A)
ALA  A  12 ( 0.0A)
GLU  A  18 ( 0.5A)
 1.34A 5a06A-3r9rA:
0.0
5a06F-3r9rA:
0.0		 5a06A-3r9rA:
22.82
5a06F-3r9rA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whe HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ARG A 269
HIS A 393
ALA A 113
GLU A 396
 None
 1.44A 5a06A-3wheA:
0.0
5a06F-3wheA:
0.0		 5a06A-3wheA:
20.00
5a06F-3wheA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT

(Salmonella
enterica) 		PF00374
(NiFeSe_Hases) 		4 ARG A  89
HIS A 115
ALA A 112
GLU A 306
 None
 1.15A 5a06A-4c3oA:
0.0
5a06F-4c3oA:
0.0		 5a06A-4c3oA:
21.12
5a06F-4c3oA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Bacillus
anthracis) 		PF02222
(ATP-grasp)
PF02826
(2-Hacid_dh_C) 		4 ARG A 107
HIS A 274
ALA A 270
GLU A 268
 ARG  A 107 (-0.6A)
HIS  A 274 (-1.0A)
ALA  A 270 ( 0.0A)
GLU  A 268 (-0.6A)
 1.34A 5a06A-4dlkA:
undetectable
5a06F-4dlkA:
1.2		 5a06A-4dlkA:
21.81
5a06F-4dlkA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2o FIXK2 PROTEIN

(Bradyrhizobium
japonicum) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 ARG A 170
HIS A 148
ALA A  84
GLU A 167
 None
 1.45A 5a06A-4i2oA:
undetectable
5a06F-4i2oA:
undetectable		 5a06A-4i2oA:
21.25
5a06F-4i2oA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]

(Rattus
norvegicus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		4 ARG A 610
HIS A 502
ALA A 501
GLU A 607
 None
 1.10A 5a06A-4ox2A:
undetectable
5a06F-4ox2A:
undetectable		 5a06A-4ox2A:
21.87
5a06F-4ox2A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxm PRIB

(Streptomyces
sp. RM-5-8) 		PF11991
(Trp_DMAT) 		4 ARG A 371
HIS A 205
ALA A 208
GLU A 300
 None
 1.33A 5a06A-5jxmA:
undetectable
5a06F-5jxmA:
0.4		 5a06A-5jxmA:
20.93
5a06F-5jxmA:
20.93