SIMILAR PATTERNS OF AMINO ACIDS FOR 5A06_E_SORE1341_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aow ANNEXIN IV

(Bos taurus) 		PF00191
(Annexin) 		4 ILE A 120
GLU A 161
GLY A 158
GLY A 157
 None
 0.72A 5a06E-1aowA:
undetectable		 5a06E-1aowA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg5 FUSION PROTEIN OF
ALPHA-NA,K-ATPASE
WITH GLUTATHIONE
S-TRANSFERASE

(Rattus
norvegicus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ILE A  92
LYS A  87
GLY A  84
GLY A  83
 None
 0.76A 5a06E-1bg5A:
undetectable		 5a06E-1bg5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 ILE A 181
CYH A 166
GLY A 179
GLY A 180
 None
 0.83A 5a06E-1c30A:
0.2		 5a06E-1c30A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7g TYROSINE
PHENOL-LYASE

(Pantoea
agglomerans) 		PF01212
(Beta_elim_lyase) 		5 ILE A 263
LEU A 294
GLU A 286
GLY A 265
GLY A 264
 None
 1.25A 5a06E-1c7gA:
undetectable		 5a06E-1c7gA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pisum sativum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ILE A 102
LEU A  46
GLY A  43
GLY A  42
 None
None
FAD  A 480 (-3.2A)
None
 0.83A 5a06E-1dxlA:
2.7		 5a06E-1dxlA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e09 PRU AV 1

(Prunus avium) 		PF00407
(Bet_v_1) 		4 ILE A  43
LYS A  70
GLY A  49
GLY A  48
 None
 0.76A 5a06E-1e09A:
undetectable		 5a06E-1e09A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II

(Synechocystis
sp. PCC 6803) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 108
CYH A 162
GLU A 195
GLY A 348
GLY A 193
 None
 1.50A 5a06E-1e5mA:
undetectable		 5a06E-1e5mA:
22.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1evj GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ILE A 142
LYS A 151
LEU A 152
GLY A 346
 None
 0.23A 5a06E-1evjA:
48.5		 5a06E-1evjA:
49.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h6d PRECURSOR FORM OF
GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ILE A 194
LYS A 203
LEU A 204
GLY A 398
 None
 0.17A 5a06E-1h6dA:
48.6		 5a06E-1h6dA:
44.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzo BETA-LACTAMASE

(Proteus
vulgaris) 		PF13354
(Beta-lactamase2) 		4 LYS A 137
LEU A 139
GLY A 143
GLY A 144
 None
 0.86A 5a06E-1hzoA:
undetectable		 5a06E-1hzoA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Trypanosoma
cruzi) 		PF01293
(PEPCK_ATP) 		5 ILE A 126
CYH A  96
LEU A 125
GLY A 257
GLY A 256
 None
 1.03A 5a06E-1ii2A:
undetectable		 5a06E-1ii2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		5 ILE A 453
LEU A 463
GLU A 543
GLY A 538
GLY A 537
 None
 1.48A 5a06E-1itkA:
undetectable		 5a06E-1itkA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ILE A 105
LEU A  49
GLY A  46
GLY A  45
 None
None
FAD  A 480 (-3.1A)
None
 0.80A 5a06E-1lpfA:
undetectable		 5a06E-1lpfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 ILE A  77
LEU A  71
GLY A  75
GLY A  76
 None
 0.86A 5a06E-1mewA:
undetectable		 5a06E-1mewA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1np3 KETOL-ACID
REDUCTOISOMERASE

(Pseudomonas
aeruginosa) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 ILE A  21
LEU A  79
GLY A  25
GLY A  28
 None
 0.73A 5a06E-1np3A:
7.0		 5a06E-1np3A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Geobacillus
stearothermophilus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 ILE A 483
LEU A  45
GLY A 481
GLY A 482
 None
 0.86A 5a06E-1o99A:
undetectable		 5a06E-1o99A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orf GRANZYME A

(Homo sapiens) 		PF00089
(Trypsin) 		4 ILE A 229
LYS A 104
LEU A 103
GLY A 101
 None
 0.84A 5a06E-1orfA:
undetectable		 5a06E-1orfA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orr CDP-TYVELOSE-2-EPIME
RASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		4 ILE A   6
LEU A  80
GLY A  11
GLY A  14
 None
NAD  A1200 (-4.4A)
NAD  A1200 (-3.1A)
None
 0.84A 5a06E-1orrA:
6.5		 5a06E-1orrA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poi GLUTACONATE COENZYME
A-TRANSFERASE

(Acidaminococcus
fermentans) 		PF01144
(CoA_trans) 		4 ILE B 171
LYS B 205
GLY B 175
GLY B 176
 None
 0.85A 5a06E-1poiB:
2.8		 5a06E-1poiB:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		4 LEU A 220
GLU A 222
GLY A 541
GLY A 542
 None
 0.75A 5a06E-1ps9A:
undetectable		 5a06E-1ps9A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER

(Rhodobacter
sphaeroides) 		PF00124
(Photo_RC) 		4 ILE L  88
LEU L  85
GLY L  83
GLY L  84
 None
 0.83A 5a06E-1pssL:
undetectable		 5a06E-1pssL:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		4 ILE A 565
CYH A 568
LEU A 575
GLY A 606
 None
 0.69A 5a06E-1qb4A:
undetectable		 5a06E-1qb4A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE

(Mus musculus) 		PF02348
(CTP_transf_3) 		5 ILE A  95
LYS A  59
LEU A  58
GLY A  52
GLY A  51
 None
 0.93A 5a06E-1qwjA:
2.8		 5a06E-1qwjA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh9 ENDO-BETA-MANNANASE

(Solanum
lycopersicum) 		PF00150
(Cellulase) 		4 ILE A 316
LEU A 315
GLY A 355
GLY A 356
 None
 0.79A 5a06E-1rh9A:
undetectable		 5a06E-1rh9A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spb SUBTILISIN BPN'
PROSEGMENT

(Bacillus
amyloliquefaciens) 		PF05922
(Inhibitor_I9) 		5 ILE P  30
LEU P  51
GLU P  58
GLY P  34
GLY P  35
 None
 1.45A 5a06E-1spbP:
undetectable		 5a06E-1spbP:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		4 ILE A1348
LEU A1306
GLY A1352
GLY A1353
 None
 0.76A 5a06E-1ug3A:
undetectable		 5a06E-1ug3A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ILE A  10
GLU A  35
GLY A  14
GLY A  17
 None
FAD  A 480 (-2.5A)
FAD  A 480 (-3.4A)
None
 0.84A 5a06E-1v59A:
undetectable		 5a06E-1v59A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00180
(Iso_dh) 		4 ILE A  41
LEU A  53
GLY A  89
GLY A  90
 None
 0.71A 5a06E-1vlcA:
2.3		 5a06E-1vlcA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxl SINGLE-STRAND
RECOGNITION PROTEIN

(Drosophila
melanogaster) 		PF00505
(HMG_box) 		4 ILE A  23
LEU A  16
GLY A  40
GLY A  39
 None
 0.83A 5a06E-1wxlA:
undetectable		 5a06E-1wxlA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		4 ILE A 200
LEU A 203
GLY A 189
GLY A 190
 None
 0.68A 5a06E-1wy0A:
undetectable		 5a06E-1wy0A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		4 ILE A 320
LEU A 389
GLY A 325
GLY A 328
 None
None
ATP  A1001 (-2.9A)
None
 0.77A 5a06E-1z7eA:
8.2		 5a06E-1z7eA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Thermotoga
maritima) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 ILE A 255
LEU A 274
GLY A 253
GLY A 254
 None
 0.78A 5a06E-1zczA:
4.4		 5a06E-1zczA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ILE A 103
LEU A  46
GLY A  43
GLY A  42
 None
None
FAD  A4750 (-2.7A)
None
 0.84A 5a06E-1zy8A:
undetectable		 5a06E-1zy8A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ash QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Thermotoga
maritima) 		PF01702
(TGT) 		4 ILE A 214
LEU A 212
GLY A 210
GLY A 211
 EDO  A 404 (-4.0A)
None
EDO  A 404 (-3.4A)
EDO  A 404 (-3.0A)
 0.84A 5a06E-2ashA:
undetectable		 5a06E-2ashA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2asy PROTEIN YDHR
PRECURSOR

(Escherichia
coli) 		PF08803
(ydhR) 		4 ILE A  53
LYS A  39
GLY A  51
GLY A  52
 None
 0.75A 5a06E-2asyA:
undetectable		 5a06E-2asyA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR

(Sus scrofa) 		PF13516
(LRR_6) 		5 ILE A 353
CYH A 375
LYS A 347
LEU A 348
GLY A 352
 None
 1.30A 5a06E-2bnhA:
undetectable		 5a06E-2bnhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE

(Enterococcus
faecalis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 ILE A   5
LEU A  78
GLY A   9
GLY A  12
 None
 0.82A 5a06E-2ew2A:
7.2		 5a06E-2ew2A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 LEU A 171
GLU A  40
GLY A 175
GLY A 176
 None
NAD  A5555 ( 4.8A)
NAD  A5555 (-3.7A)
None
 0.83A 5a06E-2fknA:
undetectable		 5a06E-2fknA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 CYH A  84
LEU A  86
GLY A  88
GLY A  89
 None
 0.79A 5a06E-2gepA:
undetectable		 5a06E-2gepA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu4 DIHYDROXYACETONE
KINASE

(Lactococcus
lactis) 		PF02733
(Dak1) 		4 ILE A  10
GLU A  55
GLY A  51
GLY A  73
 None
None
HIQ  A 215 ( 3.1A)
None
 0.76A 5a06E-2iu4A:
2.9		 5a06E-2iu4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sinapis alba) 		PF00348
(polyprenyl_synt) 		4 ILE A 215
LEU A 218
GLY A 204
GLY A 205
 None
 0.72A 5a06E-2j1oA:
undetectable		 5a06E-2j1oA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkg ACETYLCHOLINE
RECEPTOR

(Torpedo
marmorata) 		PF02932
(Neur_chan_memb) 		4 ILE A 102
GLU A  38
GLY A  44
GLY A  45
 None
 0.78A 5a06E-2lkgA:
undetectable		 5a06E-2lkgA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mq0 MYOSIN-BINDING
PROTEIN C,
CARDIAC-TYPE

(Homo sapiens) 		PF07679
(I-set) 		4 ILE A 456
LEU A 455
GLY A 531
GLY A 532
 None
 0.73A 5a06E-2mq0A:
undetectable		 5a06E-2mq0A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqa CALPAIN 8

(Homo sapiens) 		PF00648
(Peptidase_C2) 		4 LEU A 166
GLU A 182
GLY A 100
GLY A 101
 None
None
CSO  A  98 ( 4.5A)
None
 0.81A 5a06E-2nqaA:
undetectable		 5a06E-2nqaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz2 ARGININOSUCCINATE
SYNTHASE

(Homo sapiens) 		PF00764
(Arginosuc_synth) 		5 ILE A 338
CYH A 337
LEU A 313
GLY A 312
GLY A 314
 None
 1.44A 5a06E-2nz2A:
undetectable		 5a06E-2nz2A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6i HD DOMAIN PROTEIN

(Enterococcus
faecalis) 		PF01966
(HD) 		4 ILE A 218
LYS A 383
GLY A 216
GLY A 217
 None
 0.82A 5a06E-2o6iA:
undetectable		 5a06E-2o6iA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogf HYPOTHETICAL PROTEIN
MJ0408

(Methanocaldococcus
jannaschii) 		PF04038
(DHNA) 		4 ILE A  92
LEU A 101
GLY A  27
GLY A  26
 None
 0.83A 5a06E-2ogfA:
undetectable		 5a06E-2ogfA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okk GLUTAMATE
DECARBOXYLASE 2

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 LYS A 378
LEU A 371
GLY A 369
GLY A 370
 None
 0.79A 5a06E-2okkA:
undetectable		 5a06E-2okkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph5 HOMOSPERMIDINE
SYNTHASE

(Legionella
pneumophila) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 ILE A 426
LEU A 162
GLU A 295
GLY A 157
 None
None
None
NAD  A 501 (-3.0A)
 0.84A 5a06E-2ph5A:
5.9		 5a06E-2ph5A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE

(Bacillus
anthracis) 		PF01467
(CTP_transf_like) 		5 ILE A   6
CYH A  73
LEU A  37
GLY A   9
GLY A   8
 None
None
None
GOL  A 191 ( 4.0A)
None
 1.45A 5a06E-2qtnA:
undetectable		 5a06E-2qtnA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v28 PHENYLALANINE-4-HYDR
OXYLASE

(Colwellia
psychrerythraea) 		PF00351
(Biopterin_H) 		4 ILE A 179
CYH A  44
GLY A 182
GLY A 181
 None
 0.83A 5a06E-2v28A:
undetectable		 5a06E-2v28A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 LEU A 175
GLU A  44
GLY A 179
GLY A 180
 None
NAD  A3001 (-4.6A)
NAD  A3001 (-3.7A)
None
 0.79A 5a06E-2v7gA:
undetectable		 5a06E-2v7gA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8j PECTATE LYASE

(Yersinia
enterocolitica) 		PF06917
(Pectate_lyase_2) 		4 LYS A 132
LEU A 131
GLY A 108
GLY A 107
 None
 0.69A 5a06E-2v8jA:
undetectable		 5a06E-2v8jA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vw8 PA1000

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 ILE A  41
LEU A  77
GLY A  39
GLY A  40
 None
 0.82A 5a06E-2vw8A:
undetectable		 5a06E-2vw8A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2waw MOBA RELATE PROTEIN

(Mycobacterium
sp. DSM 3803) 		PF12804
(NTP_transf_3) 		5 ILE A 172
CYH A 129
LEU A 117
GLY A 121
GLY A 120
 None
 1.43A 5a06E-2wawA:
undetectable		 5a06E-2wawA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvg PYRUVATE
DECARBOXYLASE

(Zymomonas
mobilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 CYH A 537
LEU A 518
GLY A 516
GLY A 515
 None
 0.85A 5a06E-2wvgA:
2.5		 5a06E-2wvgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsx BETA-ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 LYS A 162
LEU A 163
GLY A 156
GLY A 155
 None
 0.66A 5a06E-2xsxA:
undetectable		 5a06E-2xsxA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z95 GDP-D-MANNOSE
DEHYDRATASE

(Aquifex
aeolicus) 		PF16363
(GDP_Man_Dehyd) 		4 ILE A   8
LEU A  82
GLY A  13
GLY A  16
 None
NDP  A1001 (-4.2A)
NDP  A1001 (-3.4A)
None
 0.85A 5a06E-2z95A:
7.2		 5a06E-2z95A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ap1 PROTEIN-TYROSINE
SULFOTRANSFERASE 2

(Homo sapiens) 		PF13469
(Sulfotransfer_3) 		4 LYS A 164
LEU A 163
GLY A  75
GLY A  74
 None
 0.79A 5a06E-3ap1A:
undetectable		 5a06E-3ap1A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do6 FORMATE--TETRAHYDROF
OLATE LIGASE

(Thermotoga
maritima) 		PF01268
(FTHFS) 		4 ILE A  64
LYS A  59
GLY A  95
GLY A  98
 None
 0.81A 5a06E-3do6A:
undetectable		 5a06E-3do6A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 CYH A 113
LYS A 115
LEU A 117
GLY A 369
GLY A 366
 None
 1.14A 5a06E-3dtyA:
18.2		 5a06E-3dtyA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1h PUTATIVE
UNCHARACTERIZED
PROTEIN

(Neurospora
crassa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 150
CYH A 120
GLY A 155
GLY A 154
 None
 0.77A 5a06E-3e1hA:
undetectable		 5a06E-3e1hA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2n CYTOCHROME C
PEROXIDASE

(Pisum sativum;
Saccharomyces
cerevisiae) 		PF00141
(peroxidase) 		4 ILE A  26
LEU A  39
GLY A 105
GLY A 104
 None
 0.74A 5a06E-3e2nA:
undetectable		 5a06E-3e2nA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3c L0044

(Escherichia
coli) 		PF16518
(GrlR) 		4 ILE A  25
LEU A  24
GLY A  34
GLY A  33
 None
HHG  A 150 (-4.9A)
None
None
 0.77A 5a06E-3e3cA:
undetectable		 5a06E-3e3cA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 150
CYH A 120
GLY A 155
GLY A 154
 None
 0.79A 5a06E-3euoA:
undetectable		 5a06E-3euoA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f13 PUTATIVE NUDIX
HYDROLASE FAMILY
MEMBER

(Chromobacterium
violaceum) 		PF00293
(NUDIX) 		4 ILE A  61
LEU A  57
GLY A  45
GLY A  44
 None
 0.83A 5a06E-3f13A:
undetectable		 5a06E-3f13A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwy PUTATIVE CTP
PYROPHOSPHOHYDROLASE

(Bacteroides
fragilis) 		PF00293
(NUDIX) 		4 ILE A  55
LEU A  51
GLY A  39
GLY A  38
 None
 0.82A 5a06E-3gwyA:
undetectable		 5a06E-3gwyA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h32 FIBRINOGEN BETA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 ILE B 299
LEU B 294
GLY B 272
GLY B 295
 None
 0.82A 5a06E-3h32B:
undetectable		 5a06E-3h32B:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4q PUTATIVE
ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF00583
(Acetyltransf_1) 		4 ILE A  60
GLU A  19
GLY A  94
GLY A  62
 None
None
UNL  A 170 (-4.1A)
None
 0.79A 5a06E-3h4qA:
undetectable		 5a06E-3h4qA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hr0 COG4

(Homo sapiens) 		PF04437
(RINT1_TIP1) 		4 ILE A 634
GLU A 707
GLY A 701
GLY A 700
 None
 0.86A 5a06E-3hr0A:
undetectable		 5a06E-3hr0A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvm AGMATINE DEIMINASE

(Helicobacter
pylori) 		PF04371
(PAD_porph) 		4 ILE A  88
GLU A 145
GLY A 142
GLY A 141
 None
 0.65A 5a06E-3hvmA:
undetectable		 5a06E-3hvmA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3l ALKYLHALIDASE CMLS

(Streptomyces
venezuelae) 		PF04820
(Trp_halogenase) 		4 ILE A  31
LEU A 115
GLY A  12
GLY A  11
 None
None
FAD  A 600 (-3.6A)
None
 0.76A 5a06E-3i3lA:
2.6		 5a06E-3i3lA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Colwellia
psychrerythraea) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ILE A  10
GLU A  35
GLY A  14
GLY A  17
 None
FAD  A 490 (-2.8A)
FAD  A 490 (-3.2A)
None
 0.81A 5a06E-3ic9A:
undetectable		 5a06E-3ic9A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie5 PHENOLIC OXIDATIVE
COUPLING PROTEIN
HYP-1

(Hypericum
perforatum) 		PF00407
(Bet_v_1) 		4 ILE A  44
LYS A  71
GLY A  50
GLY A  49
 None
PG4  A 508 (-2.8A)
None
None
 0.80A 5a06E-3ie5A:
undetectable		 5a06E-3ie5A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krb ALDOSE REDUCTASE

(Giardia
intestinalis) 		PF00248
(Aldo_ket_red) 		4 ILE A 224
CYH A 227
LYS A 231
LEU A 230
 None
 0.72A 5a06E-3krbA:
undetectable		 5a06E-3krbA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 4 ILE X  98
LEU X 167
GLY X 145
GLY X 144
 None
 0.85A 5a06E-3kvnX:
2.9		 5a06E-3kvnX:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 4 LEU X 616
GLU X 329
GLY X 600
GLY X 599
 None
 0.82A 5a06E-3kvnX:
2.9		 5a06E-3kvnX:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxq TRIOSEPHOSPHATE
ISOMERASE

(Bartonella
henselae) 		PF00121
(TIM) 		4 LYS A  88
LEU A  87
GLY A  66
GLY A  67
 None
 0.64A 5a06E-3kxqA:
2.4		 5a06E-3kxqA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		4 ILE A 245
GLU A 403
GLY A 216
GLY A 213
 LLP  A 270 ( 4.2A)
None
None
None
 0.86A 5a06E-3l44A:
undetectable		 5a06E-3l44A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqz HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DP ALPHA 1
CHAIN

(Homo sapiens) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		4 ILE A  63
LEU A  60
GLY A  58
GLY A  59
 None
 0.83A 5a06E-3lqzA:
undetectable		 5a06E-3lqzA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lun ULILYSIN

(Methanosarcina
acetivorans) 		PF05572
(Peptidase_M43) 		4 ILE A 205
CYH A 176
LEU A 179
GLY A 189
 None
 0.77A 5a06E-3lunA:
undetectable		 5a06E-3lunA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn3 CARBON
CATABOLITE-DEREPRESS
ING PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 ILE A 283
LEU A 282
GLU A 151
GLY A 278
GLY A 281
 None
 1.48A 5a06E-3mn3A:
undetectable		 5a06E-3mn3A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0l SERINE
HYDROXYMETHYLTRANSFE
RASE

(Campylobacter
jejuni) 		PF00464
(SHMT) 		4 ILE A 395
LYS A 400
LEU A 399
GLY A 334
 None
 0.80A 5a06E-3n0lA:
undetectable		 5a06E-3n0lA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3t PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE

(Thiobacillus
denitrificans) 		PF00563
(EAL) 		5 CYH A 562
LEU A 581
GLU A 614
GLY A 521
GLY A 522
 None
 1.44A 5a06E-3n3tA:
undetectable		 5a06E-3n3tA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5m ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		5 ILE A 227
LEU A 228
GLU A 219
GLY A 225
GLY A 226
 None
 1.18A 5a06E-3n5mA:
undetectable		 5a06E-3n5mA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		4 ILE A  49
LYS A  52
LEU A  81
GLY A  82
 None
 0.74A 5a06E-3o5eA:
undetectable		 5a06E-3o5eA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1v METALLO-ENDOPEPTIDAS
E

(Bacteroides
ovatus) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		5 ILE A 416
CYH A 412
LEU A 320
GLY A 319
GLY A 318
 None
ZN  A 427 (-2.2A)
None
None
None
 1.23A 5a06E-3p1vA:
undetectable		 5a06E-3p1vA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8l GERANYLTRANSTRANSFER
ASE

(Enterococcus
faecalis) 		PF00348
(polyprenyl_synt) 		4 ILE A 199
LEU A 202
GLY A 188
GLY A 189
 None
 0.65A 5a06E-3p8lA:
undetectable		 5a06E-3p8lA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		4 ILE B 194
CYH B 197
GLY B 179
GLY B 180
 None
 0.69A 5a06E-3pz2B:
undetectable		 5a06E-3pz2B:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr1 PUTATIVE
D-GALACTONATE
DEHYDRATASE

(Ralstonia
pickettii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 265
CYH A 296
LEU A 259
GLY A 263
GLY A 264
 None
 1.43A 5a06E-3rr1A:
undetectable		 5a06E-3rr1A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		4 ILE B 573
CYH B 618
LEU B 561
GLY B 572
 None
 0.85A 5a06E-3s4wB:
undetectable		 5a06E-3s4wB:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t33 G PROTEIN COUPLED
RECEPTOR

(Arabidopsis
thaliana) 		PF05147
(LANC_like) 		4 ILE A 327
LEU A 383
GLY A 388
GLY A 389
 None
 0.77A 5a06E-3t33A:
undetectable		 5a06E-3t33A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc1 OCTAPRENYL
PYROPHOSPHATE
SYNTHASE

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		4 ILE A 167
LYS A 172
LEU A 171
GLY A 189
 None
 0.75A 5a06E-3tc1A:
undetectable		 5a06E-3tc1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqh QUINONE
OXIDOREDUCTASE

(Coxiella
burnetii) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 ILE A 155
LEU A 219
GLY A 160
GLY A 163
 None
NDP  A 500 (-4.4A)
NDP  A 500 (-3.6A)
None
 0.85A 5a06E-3tqhA:
7.4		 5a06E-3tqhA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx3 UNCHARACTERIZED
PROTEIN INVOLVED IN
CYSTEINE
BIOSYNTHESIS

(Idiomarina
loihiensis) 		PF07264
(EI24) 		4 ILE A  14
LEU A  11
GLY A 208
GLY A 210
 None
 0.86A 5a06E-3tx3A:
undetectable		 5a06E-3tx3A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vup BETA-1,4-MANNANASE

(Aplysia kurodai) 		PF00150
(Cellulase) 		5 ILE A 104
LYS A  49
LEU A  51
GLY A  55
GLY A  56
 None
 1.27A 5a06E-3vupA:
undetectable		 5a06E-3vupA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vw5 CELLOBIOSE
2-EPIMERASE

(Ruminococcus
albus) 		PF07221
(GlcNAc_2-epim) 		4 ILE A 112
LEU A 138
GLY A  90
GLY A  91
 None
 0.78A 5a06E-3vw5A:
undetectable		 5a06E-3vw5A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w2w CRISPR SYSTEM CMR
SUBUNIT CMR3

(Pyrococcus
furiosus) 		PF09700
(Cas_Cmr3) 		4 ILE B 320
LEU B 227
GLY B 318
GLY B 319
 None
 0.82A 5a06E-3w2wB:
undetectable		 5a06E-3w2wB:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		PF09481
(CRISPR_Cse1) 		5 ILE A 420
LEU A 333
GLU A 427
GLY A 332
GLY A 334
 None
 1.37A 5a06E-3wvoA:
undetectable		 5a06E-3wvoA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxy PUTATIVE
UNCHARACTERIZED
PROTEIN CSYB

(Aspergillus
oryzae) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 153
CYH A 123
GLY A 158
GLY A 157
 None
 0.82A 5a06E-3wxyA:
undetectable		 5a06E-3wxyA:
22.53