SIMILAR PATTERNS OF AMINO ACIDS FOR 5A06_D_SORD1343_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 ALA A 263
ARG A 260
ALA A 273
GLU A 124
 None
 1.40A 5a06C-1bf2A:
undetectable
5a06D-1bf2A:
undetectable		 5a06C-1bf2A:
18.19
5a06D-1bf2A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		4 ALA A 550
ARG A 556
ALA A 705
GLU A 557
 None
 1.42A 5a06C-1e4oA:
3.1
5a06D-1e4oA:
3.0		 5a06C-1e4oA:
20.80
5a06D-1e4oA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idu VANADIUM
CHLOROPEROXIDASE

(Curvularia
inaequalis) 		PF01569
(PAP2) 		4 ALA A 385
ARG A 469
ALA A 383
GLU A 443
 None
 1.29A 5a06C-1iduA:
undetectable
5a06D-1iduA:
undetectable		 5a06C-1iduA:
20.81
5a06D-1iduA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ALA A 482
HIS A 452
ALA A 454
GLU A 487
 None
 1.40A 5a06C-1mdfA:
3.2
5a06D-1mdfA:
3.4		 5a06C-1mdfA:
21.01
5a06D-1mdfA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt0 HEMOLYSIN SECRETION
ATP-BINDING PROTEIN

(Escherichia
coli) 		PF00005
(ABC_tran) 		4 ALA A 661
ARG A 663
ALA A 632
GLU A 641
 None
 1.36A 5a06C-1mt0A:
undetectable
5a06D-1mt0A:
undetectable		 5a06C-1mt0A:
19.01
5a06D-1mt0A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7g NAD-DEPENDENT
DEACETYLASE 2

(Archaeoglobus
fulgidus) 		PF02146
(SIR2) 		4 ALA A  62
ARG A  58
ALA A  51
GLU A  48
 None
None
EDO  A 505 ( 4.0A)
None
 1.46A 5a06C-1s7gA:
4.4
5a06D-1s7gA:
4.4		 5a06C-1s7gA:
20.69
5a06D-1s7gA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjz ENDOGLUCANASE

(Thermotoga
maritima) 		PF00150
(Cellulase) 		4 ALA A 109
HIS A  47
ALA A  88
GLU A  99
 None
 0.96A 5a06C-1vjzA:
undetectable
5a06D-1vjzA:
undetectable		 5a06C-1vjzA:
22.54
5a06D-1vjzA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vm7 RIBOKINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		4 ALA A 251
ARG A 289
ALA A 265
GLU A 258
 None
 1.35A 5a06C-1vm7A:
2.4
5a06D-1vm7A:
4.8		 5a06C-1vm7A:
20.86
5a06D-1vm7A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		4 ALA A 397
HIS A 580
ALA A 572
GLU A 505
 None
 1.44A 5a06C-1xjeA:
undetectable
5a06D-1xjeA:
undetectable		 5a06C-1xjeA:
20.60
5a06D-1xjeA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xsa BIS(5'-NUCLEOSYL)-TE
TRAPHOSPHATASE

(Homo sapiens) 		PF00293
(NUDIX) 		4 ALA A  63
HIS A  49
ALA A  10
GLU A  54
 None
 1.47A 5a06C-1xsaA:
undetectable
5a06D-1xsaA:
undetectable		 5a06C-1xsaA:
19.76
5a06D-1xsaA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6n HYPOTHETICAL PROTEIN
PA1234

(Pseudomonas
aeruginosa) 		PF14595
(Thioredoxin_9) 		4 ALA A  74
ARG A  81
ALA A  30
GLU A  37
 None
 1.28A 5a06C-1z6nA:
undetectable
5a06D-1z6nA:
undetectable		 5a06C-1z6nA:
22.06
5a06D-1z6nA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE

(Streptococcus
pneumoniae) 		PF01048
(PNP_UDP_1) 		4 ALA A 170
ARG A 193
HIS A  98
ALA A 146
 None
MTM  A 301 (-3.2A)
None
None
 1.13A 5a06C-1zosA:
2.6
5a06D-1zosA:
undetectable		 5a06C-1zosA:
22.94
5a06D-1zosA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ciy CHLOROPEROXIDASE

(Leptoxyphium
fumago) 		PF01328
(Peroxidase_2) 		4 ALA A  27
ARG A 111
ALA A  31
GLU A 217
 None
None
HEM  A 396 (-3.5A)
None
 1.19A 5a06C-2ciyA:
undetectable
5a06D-2ciyA:
undetectable		 5a06C-2ciyA:
22.52
5a06D-2ciyA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fjc ANTIGEN TPF1

(Treponema
pallidum) 		PF00210
(Ferritin) 		4 ALA A  44
ARG A  40
ALA A 106
GLU A 103
 None
 1.41A 5a06C-2fjcA:
undetectable
5a06D-2fjcA:
undetectable		 5a06C-2fjcA:
19.41
5a06D-2fjcA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II

(Thermotoga
maritima) 		PF00586
(AIRS)
PF02769
(AIRS_C)
PF16904
(PurL_C) 		4 ALA A 408
HIS A 405
ALA A 422
GLU A 137
 None
 1.36A 5a06C-2hruA:
undetectable
5a06D-2hruA:
undetectable		 5a06C-2hruA:
21.77
5a06D-2hruA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ism PUTATIVE
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF07995
(GSDH) 		4 ALA A  47
ARG A 139
ALA A  37
GLU A 319
 None
 1.46A 5a06C-2ismA:
undetectable
5a06D-2ismA:
undetectable		 5a06C-2ismA:
23.76
5a06D-2ismA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6r AFUHEL308 HELICASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ALA A 267
ARG A 296
ALA A 299
GLU A 293
 None
 1.38A 5a06C-2p6rA:
undetectable
5a06D-2p6rA:
undetectable		 5a06C-2p6rA:
19.74
5a06D-2p6rA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 176
ARG A 210
ALA A 168
GLU A 170
 None
 1.03A 5a06C-2pceA:
undetectable
5a06D-2pceA:
2.1		 5a06C-2pceA:
24.29
5a06D-2pceA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2k D-MANDELATE
DEHYDROGENASE

(Rhodotorula
graminis) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ALA B 138
ARG B 149
HIS B 298
GLU B 153
 None
 1.20A 5a06C-2w2kB:
6.7
5a06D-2w2kB:
6.8		 5a06C-2w2kB:
22.07
5a06D-2w2kB:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE

(Xanthomonas
campestris) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 ALA A 431
ARG A 474
HIS A 462
ALA A 458
 None
 1.25A 5a06C-2wpgA:
undetectable
5a06D-2wpgA:
undetectable		 5a06C-2wpgA:
18.24
5a06D-2wpgA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqy ENVELOPE
GLYCOPROTEIN H

(Suid
alphaherpesvirus
1) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 ALA A 252
ARG A 272
ALA A 424
GLU A 239
 None
 1.30A 5a06C-2xqyA:
undetectable
5a06D-2xqyA:
undetectable		 5a06C-2xqyA:
18.92
5a06D-2xqyA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y2c 1,6-ANHYDRO-N-ACETYL
MURAMYL-L-ALANINE
AMIDASE AMPD

(Citrobacter
freundii) 		PF01510
(Amidase_2) 		4 ALA A  94
ARG A  22
HIS A  34
ALA A  97
 None
 1.44A 5a06C-2y2cA:
undetectable
5a06D-2y2cA:
undetectable		 5a06C-2y2cA:
16.81
5a06D-2y2cA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp2 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ARG A 269
HIS A 393
ALA A 113
GLU A 396
 None
 1.27A 5a06C-2yp2A:
undetectable
5a06D-2yp2A:
undetectable		 5a06C-2yp2A:
20.00
5a06D-2yp2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Homo sapiens) 		PF01593
(Amino_oxidase) 		4 ALA A 448
ARG A  51
ALA A 272
GLU A 436
 FAD  A 600 (-3.5A)
FAD  A 600 (-3.7A)
None
None
 1.25A 5a06C-2z5xA:
undetectable
5a06D-2z5xA:
undetectable		 5a06C-2z5xA:
20.40
5a06D-2z5xA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Homo sapiens) 		PF01593
(Amino_oxidase) 		4 ALA A 448
ARG A  51
ALA A 433
GLU A 436
 FAD  A 600 (-3.5A)
FAD  A 600 (-3.7A)
None
None
 1.11A 5a06C-2z5xA:
undetectable
5a06D-2z5xA:
undetectable		 5a06C-2z5xA:
20.40
5a06D-2z5xA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 ALA A 411
ARG A 461
ALA A 484
GLU A 482
 None
 1.22A 5a06C-2zv7A:
undetectable
5a06D-2zv7A:
undetectable		 5a06C-2zv7A:
22.35
5a06D-2zv7A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajx 3-HEXULOSE-6-PHOSPHA
TE SYNTHASE

(Mycobacterium
gastri) 		PF00215
(OMPdecase) 		4 ALA A1185
HIS A1134
ALA A1164
GLU A1030
 None
MG  A9100 ( 4.5A)
None
MG  A9100 (-2.9A)
 1.41A 5a06C-3ajxA:
3.5
5a06D-3ajxA:
2.6		 5a06C-3ajxA:
22.19
5a06D-3ajxA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayh DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC9
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC8

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF03874
(RNA_pol_Rpb4)
PF03876
(SHS2_Rpb7-N)
PF08292
(RNA_pol_Rbc25) 		4 ALA B  27
ARG A  30
HIS A  19
GLU A  26
 None
 0.77A 5a06C-3ayhB:
undetectable
5a06D-3ayhB:
undetectable		 5a06C-3ayhB:
19.94
5a06D-3ayhB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dg7 MUCONATE
CYCLOISOMERASE

(Mycolicibacterium
smegmatis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A  90
ARG A 277
ALA A  85
GLU A  83
 None
 1.22A 5a06C-3dg7A:
3.1
5a06D-3dg7A:
3.1		 5a06C-3dg7A:
25.00
5a06D-3dg7A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ALA A 531
ARG A 801
ALA A 795
GLU A 766
 None
 1.35A 5a06C-3fg4A:
undetectable
5a06D-3fg4A:
undetectable		 5a06C-3fg4A:
18.95
5a06D-3fg4A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		4 ALA A 574
ARG A 550
HIS A 582
ALA A 579
 None
 1.41A 5a06C-3gsiA:
4.1
5a06D-3gsiA:
undetectable		 5a06C-3gsiA:
18.16
5a06D-3gsiA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjw PSEUDOURIDINE
SYNTHASE CBF5

(Pyrococcus
furiosus) 		PF01472
(PUA)
PF01509
(TruB_N)
PF08068
(DKCLD)
PF16198
(TruB_C_2) 		4 ALA A  99
ARG A  41
ALA A 249
GLU A 247
 None
 1.32A 5a06C-3hjwA:
undetectable
5a06D-3hjwA:
undetectable		 5a06C-3hjwA:
22.70
5a06D-3hjwA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnb N-ACETYLTRANSFERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00797
(Acetyltransf_2) 		4 ALA A  45
ARG A  65
ALA A 220
GLU A  39
 None
 1.42A 5a06C-3lnbA:
undetectable
5a06D-3lnbA:
undetectable		 5a06C-3lnbA:
22.40
5a06D-3lnbA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1a PUTATIVE
DEHYDROGENASE

(Streptomyces
avermitilis) 		PF00106
(adh_short) 		4 ALA A  53
ARG A  19
ALA A  25
GLU A  23
 None
 1.12A 5a06C-3m1aA:
2.2
5a06D-3m1aA:
1.6		 5a06C-3m1aA:
23.89
5a06D-3m1aA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oac GERANYL DIPHOSPHATE
SYNTHASE SMALL
SUBUNIT

(Mentha x
piperita) 		no annotation 4 ALA B 188
ARG B 137
ALA B 196
GLU B 198
 None
 1.17A 5a06C-3oacB:
undetectable
5a06D-3oacB:
undetectable		 5a06C-3oacB:
22.93
5a06D-3oacB:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFE

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		4 ALA A 207
HIS A 212
ALA A 426
GLU A 433
 None
 1.37A 5a06C-3pdiA:
4.6
5a06D-3pdiA:
undetectable		 5a06C-3pdiA:
21.26
5a06D-3pdiA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qax PROBABLE ABC
TRANSPORTER
ARGININE-BINDING
PROTEIN ARTJ

(Chlamydia
pneumoniae) 		PF00497
(SBP_bac_3) 		4 ALA A  72
HIS A  68
ALA A 200
GLU A 206
 None
 1.44A 5a06C-3qaxA:
undetectable
5a06D-3qaxA:
undetectable		 5a06C-3qaxA:
23.55
5a06D-3qaxA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0z D-SERINE DEHYDRATASE

(Salmonella
enterica) 		PF00291
(PALP) 		4 ALA A 194
ARG A 201
ALA A 192
GLU A 209
 None
 0.96A 5a06C-3r0zA:
2.5
5a06D-3r0zA:
2.5		 5a06C-3r0zA:
21.96
5a06D-3r0zA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfw DIHYDROPYRIMIDINASE

(Brevibacillus
agri) 		PF01979
(Amidohydro_1) 		4 ALA A 216
ARG A 292
HIS A 183
ALA A 184
 None
None
ZN  A 501 (-3.3A)
None
 1.24A 5a06C-3sfwA:
undetectable
5a06D-3sfwA:
undetectable		 5a06C-3sfwA:
22.84
5a06D-3sfwA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		4 ALA X 196
ARG X 203
ALA X 194
GLU X 211
 None
 1.03A 5a06C-3ss7X:
2.6
5a06D-3ss7X:
2.6		 5a06C-3ss7X:
22.95
5a06D-3ss7X:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tnf LIDA

(Legionella
pneumophila) 		no annotation 4 ALA B 305
ARG B 449
HIS B 396
GLU B 392
 None
 1.30A 5a06C-3tnfB:
undetectable
5a06D-3tnfB:
undetectable		 5a06C-3tnfB:
20.39
5a06D-3tnfB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0k RCAMP

(Entacmaea
quadricolor) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 ALA A 135
ARG A 218
ALA A 137
GLU A  63
 ACT  A 443 (-3.5A)
ACT  A 443 (-3.6A)
None
CRK  A 214 ( 4.1A)
 1.06A 5a06C-3u0kA:
undetectable
5a06D-3u0kA:
undetectable		 5a06C-3u0kA:
21.56
5a06D-3u0kA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		4 ALA A 756
HIS A 399
ALA A 704
GLU A 749
 None
 1.36A 5a06C-3ummA:
2.6
5a06D-3ummA:
2.9		 5a06C-3ummA:
14.34
5a06D-3ummA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ALA A 164
ARG A 417
ALA A 411
GLU A 382
 None
 1.25A 5a06C-3vf1A:
undetectable
5a06D-3vf1A:
undetectable		 5a06C-3vf1A:
17.20
5a06D-3vf1A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrf NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bifidobacterium
longum) 		PF07944
(Glyco_hydro_127) 		4 ALA A 344
HIS A 270
ALA A 271
GLU A 338
 None
 1.16A 5a06C-3wrfA:
undetectable
5a06D-3wrfA:
undetectable		 5a06C-3wrfA:
20.94
5a06D-3wrfA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wuy NITRILASE

(Synechocystis
sp. PCC 6803) 		PF00795
(CN_hydrolase) 		4 ALA A 267
HIS A 261
ALA A 253
GLU A 207
 None
 1.20A 5a06C-3wuyA:
undetectable
5a06D-3wuyA:
undetectable		 5a06C-3wuyA:
24.05
5a06D-3wuyA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anf ORNITHINE
CARBAMOYLTRANSFERASE
, CATABOLIC

(Mycoplasma
penetrans) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ALA A 321
ARG A  61
HIS A 281
ALA A 279
 None
 1.25A 5a06C-4anfA:
4.5
5a06D-4anfA:
4.6		 5a06C-4anfA:
20.43
5a06D-4anfA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE

(Variovorax
paradoxus) 		PF00202
(Aminotran_3) 		4 ALA A  78
ARG A  41
HIS A  83
ALA A  74
 None
IK2  A1435 (-4.0A)
None
None
 1.21A 5a06C-4aoaA:
2.6
5a06D-4aoaA:
3.1		 5a06C-4aoaA:
23.99
5a06D-4aoaA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpn NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		4 ALA A 130
ARG A 153
HIS A 100
ALA A 440
 None
ZMR  A 700 (-4.2A)
None
None
 1.08A 5a06C-4cpnA:
undetectable
5a06D-4cpnA:
undetectable		 5a06C-4cpnA:
21.05
5a06D-4cpnA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Bacillus
anthracis) 		PF02222
(ATP-grasp)
PF02826
(2-Hacid_dh_C) 		4 ARG A 107
HIS A 274
ALA A 270
GLU A 268
 ARG  A 107 (-0.6A)
HIS  A 274 (-1.0A)
ALA  A 270 ( 0.0A)
GLU  A 268 (-0.6A)
 1.41A 5a06C-4dlkA:
undetectable
5a06D-4dlkA:
undetectable		 5a06C-4dlkA:
21.81
5a06D-4dlkA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM

(Sulfolobus
solfataricus) 		no annotation 4 ALA B 573
ARG B 588
ALA B 314
GLU B 311
 None
 1.35A 5a06C-4fdgB:
undetectable
5a06D-4fdgB:
undetectable		 5a06C-4fdgB:
20.20
5a06D-4fdgB:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hgx XYLOSE ISOMERASE
DOMAIN CONTAINING
PROTEIN

(Salmonella
enterica) 		PF01261
(AP_endonuc_2) 		4 ALA A  72
ARG A  39
HIS A 173
GLU A 245
 None
None
None
ZN  A 301 (-2.1A)
 1.31A 5a06C-4hgxA:
2.0
5a06D-4hgxA:
undetectable		 5a06C-4hgxA:
22.44
5a06D-4hgxA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ioh TLL1086 PROTEIN

(Thermosynechococcus
elongatus) 		PF09996
(DUF2237) 		4 ALA A  91
HIS A 118
ALA A  94
GLU A  48
 None
 1.30A 5a06C-4iohA:
undetectable
5a06D-4iohA:
undetectable		 5a06C-4iohA:
15.59
5a06D-4iohA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2n ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE

(Magnetospirillum
magneticum) 		PF00378
(ECH_1) 		4 ALA A 148
ARG A  95
ALA A 143
GLU A 115
 None
 1.16A 5a06C-4k2nA:
2.4
5a06D-4k2nA:
2.7		 5a06C-4k2nA:
23.33
5a06D-4k2nA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqn D-HYDANTOINASE

(Bacillus sp.
AR9) 		PF01979
(Amidohydro_1) 		4 ALA A 216
ARG A 292
HIS A 183
ALA A 184
 ALA  A 216 ( 0.0A)
ARG  A 292 ( 0.6A)
HIS  A 183 (-1.0A)
ALA  A 184 ( 0.0A)
 1.26A 5a06C-4kqnA:
2.4
5a06D-4kqnA:
2.0		 5a06C-4kqnA:
21.91
5a06D-4kqnA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mf9 HEMIN DEGRADING
FACTOR

(Pseudomonas
aeruginosa) 		PF05171
(HemS) 		4 ALA A 123
ARG A 168
ALA A 125
GLU A 161
 None
 1.27A 5a06C-4mf9A:
undetectable
5a06D-4mf9A:
undetectable		 5a06C-4mf9A:
21.52
5a06D-4mf9A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myn FORMIMINOGLUTAMASE

(Trypanosoma
cruzi) 		PF00491
(Arginase) 		4 ALA A 176
ARG A 204
ALA A 211
GLU A 252
 None
 1.33A 5a06C-4mynA:
undetectable
5a06D-4mynA:
undetectable		 5a06C-4mynA:
22.38
5a06D-4mynA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Geobacter
sulfurreducens) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 ALA A 331
ARG A 456
ALA A 451
GLU A 448
 None
 1.34A 5a06C-4nmeA:
4.9
5a06D-4nmeA:
2.4		 5a06C-4nmeA:
16.31
5a06D-4nmeA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9j RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		no annotation 4 ARG C1110
HIS C1133
ALA C1121
GLU C1119
 None
 1.32A 5a06C-4p9jC:
undetectable
5a06D-4p9jC:
undetectable		 5a06C-4p9jC:
18.42
5a06D-4p9jC:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qc8 VP2

(Ungulate
bocaparvovirus
1) 		PF00740
(Parvo_coat) 		4 ALA A 519
ARG A 418
ALA A 517
GLU A 183
 None
 1.23A 5a06C-4qc8A:
undetectable
5a06D-4qc8A:
undetectable		 5a06C-4qc8A:
18.86
5a06D-4qc8A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		4 ALA A 333
HIS A 259
ALA A 260
GLU A 327
 None
None
None
ACT  A 701 ( 4.8A)
 1.06A 5a06C-4qjyA:
undetectable
5a06D-4qjyA:
undetectable		 5a06C-4qjyA:
20.16
5a06D-4qjyA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ALA A1041
ARG A 853
ALA A1012
GLU A1010
 None
 1.43A 5a06C-4rcnA:
3.3
5a06D-4rcnA:
3.2		 5a06C-4rcnA:
15.13
5a06D-4rcnA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umz CYTOCHROME P450
HYDROXYLASE PIKC

(Streptomyces
venezuelae) 		PF00067
(p450) 		4 ALA A 357
HIS A 344
ALA A 346
GLU A 281
 None
None
HEM  A1407 (-4.9A)
None
 1.43A 5a06C-4umzA:
undetectable
5a06D-4umzA:
undetectable		 5a06C-4umzA:
22.39
5a06D-4umzA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjg HAPTOGLOBIN-HEMOGLOB
IN RECEPTOR

(Trypanosoma
brucei) 		no annotation 4 ALA E  52
ARG E 199
ALA E 170
GLU E 172
 None
 1.13A 5a06C-4wjgE:
undetectable
5a06D-4wjgE:
undetectable		 5a06C-4wjgE:
21.84
5a06D-4wjgE:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmv AMINOPEPTIDASE N

(Escherichia
coli) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 ALA A 795
ARG A 840
HIS A 583
ALA A 636
 None
 1.33A 5a06C-4xmvA:
undetectable
5a06D-4xmvA:
undetectable		 5a06C-4xmvA:
18.71
5a06D-4xmvA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yt9 PEPTIDYLARGININE
DEIMINASE

(Porphyromonas
gingivalis) 		PF04371
(PAD_porph) 		4 ALA A 136
ARG A  56
ALA A 357
GLU A  62
 None
GOL  A 505 (-4.9A)
None
None
 1.31A 5a06C-4yt9A:
undetectable
5a06D-4yt9A:
undetectable		 5a06C-4yt9A:
23.04
5a06D-4yt9A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv4 ELONGATION FACTOR TU

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 ALA A 297
ARG A 237
ALA A 371
GLU A 373
 None
 1.18A 5a06C-4zv4A:
5.6
5a06D-4zv4A:
2.9		 5a06C-4zv4A:
23.64
5a06D-4zv4A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6c G-PROTEIN-SIGNALING
MODULATOR 2, AFADIN

(Homo sapiens) 		PF13176
(TPR_7)
PF13181
(TPR_8)
PF13424
(TPR_12) 		4 ALA A 225
ARG A 236
ALA A 192
GLU A 377
 None
 1.46A 5a06C-5a6cA:
undetectable
5a06D-5a6cA:
undetectable		 5a06C-5a6cA:
22.62
5a06D-5a6cA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE

(Thermoproteus
uzoniensis) 		PF01063
(Aminotran_4) 		4 ALA A 161
ARG A 166
ALA A 133
GLU A 172
 None
 1.47A 5a06C-5ce8A:
undetectable
5a06D-5ce8A:
undetectable		 5a06C-5ce8A:
20.85
5a06D-5ce8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 ALA A 556
HIS A 463
ALA A 560
GLU A 468
 None
 0.96A 5a06C-5cioA:
undetectable
5a06D-5cioA:
undetectable		 5a06C-5cioA:
18.90
5a06D-5cioA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		4 ALA A  32
ARG A1091
ALA A  72
GLU A  68
 None
 1.34A 5a06C-5cjuA:
2.2
5a06D-5cjuA:
3.7		 5a06C-5cjuA:
15.64
5a06D-5cjuA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9g ISOCITRATE LYASE

(Magnaporthe
oryzae) 		PF00463
(ICL) 		4 ALA A 125
HIS A 204
ALA A 178
GLU A 206
 None
GLV  A 601 (-4.6A)
None
MG  A 603 ( 4.7A)
 1.15A 5a06C-5e9gA:
undetectable
5a06D-5e9gA:
undetectable		 5a06C-5e9gA:
19.46
5a06D-5e9gA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9h ISOCITRATE LYASE

(Fusarium
graminearum) 		PF00463
(ICL) 		4 ALA A 125
HIS A 204
ALA A 178
GLU A 206
 None
 1.06A 5a06C-5e9hA:
undetectable
5a06D-5e9hA:
2.9		 5a06C-5e9hA:
21.48
5a06D-5e9hA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxe EUGENOL OXIDASE

(Rhodococcus
jostii) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 ALA A 423
ARG A 278
ALA A 285
GLU A 378
 None
CIY  A 602 ( 4.4A)
None
CIY  A 602 (-3.6A)
 1.19A 5a06C-5fxeA:
undetectable
5a06D-5fxeA:
undetectable		 5a06C-5fxeA:
19.78
5a06D-5fxeA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT SKI6

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 ALA B 215
HIS B 222
ALA B 219
GLU B 194
 None
 1.29A 5a06C-5g06B:
undetectable
5a06D-5g06B:
undetectable		 5a06C-5g06B:
20.83
5a06D-5g06B:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu6 HAPTOGLOBIN-HEMOGLOB
IN RECEPTOR

(Trypanosoma
brucei) 		no annotation 4 ALA D  52
ARG D 199
ALA D 170
GLU D 172
 None
HEM  B 201 (-3.9A)
None
None
 1.32A 5a06C-5hu6D:
undetectable
5a06D-5hu6D:
undetectable		 5a06C-5hu6D:
23.70
5a06D-5hu6D:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy5 TRYPTOPHAN
6-HALOGENASE

(Streptomyces
toxytricini) 		PF04820
(Trp_halogenase) 		4 ALA A 502
ARG A 102
ALA A 130
GLU A  99
 None
 1.11A 5a06C-5hy5A:
4.9
5a06D-5hy5A:
undetectable		 5a06C-5hy5A:
21.54
5a06D-5hy5A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1

(Burkholderia
thailandensis) 		PF05853
(BKACE) 		4 ALA A 861
ARG A 714
HIS A 854
ALA A 720
 None
 1.33A 5a06C-5ikzA:
2.0
5a06D-5ikzA:
undetectable		 5a06C-5ikzA:
15.58
5a06D-5ikzA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwr CIRCADIAN CLOCK
PROTEIN KINASE KAIC
CIRCADIAN CLOCK
PROTEIN KAIB

(Thermosynechococcus
elongatus;
Thermosynechococcus
elongatus) 		PF06745
(ATPase)
PF07689
(KaiB) 		4 ALA B  15
ARG A 167
ALA A 126
GLU A 164
 None
 1.47A 5a06C-5jwrB:
undetectable
5a06D-5jwrB:
undetectable		 5a06C-5jwrB:
16.19
5a06D-5jwrB:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdr ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
ALPHA

(Staphylococcus
aureus) 		PF03255
(ACCA) 		4 ALA A 241
ARG A  61
ALA A 226
GLU A 224
 None
 1.34A 5a06C-5kdrA:
3.6
5a06D-5kdrA:
3.5		 5a06C-5kdrA:
21.58
5a06D-5kdrA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC

(Streptomyces
sp. BC16019) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 ALA A 168
ARG A 300
ALA A 132
GLU A 175
 None
 1.39A 5a06C-5lhkA:
undetectable
5a06D-5lhkA:
undetectable		 5a06C-5lhkA:
21.76
5a06D-5lhkA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhj MAJOR VIRAL
TRANSCRIPTION FACTOR
ICP4

(Human
alphaherpesvirus
1) 		PF03584
(Herpes_ICP4_N) 		4 ALA A 406
ARG A 336
ALA A 342
GLU A 365
 None
 1.21A 5a06C-5mhjA:
undetectable
5a06D-5mhjA:
undetectable		 5a06C-5mhjA:
22.12
5a06D-5mhjA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhk RS1

(Human
alphaherpesvirus
1) 		PF03584
(Herpes_ICP4_N) 		4 ALA A 406
ARG A 336
ALA A 342
GLU A 365
 None
 1.20A 5a06C-5mhkA:
undetectable
5a06D-5mhkA:
undetectable		 5a06C-5mhkA:
22.22
5a06D-5mhkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mmh HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR

(Pseudomonas
aeruginosa) 		PF03466
(LysR_substrate) 		4 ALA A 240
ARG A 253
ALA A 163
GLU A 258
 None
 1.36A 5a06C-5mmhA:
undetectable
5a06D-5mmhA:
undetectable		 5a06C-5mmhA:
22.22
5a06D-5mmhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npu ANC27

(synthetic
construct) 		no annotation 4 ALA A 422
HIS A 415
ALA A  83
GLU A 410
 None
TPP  A 602 (-3.0A)
None
None
 1.47A 5a06C-5npuA:
3.1
5a06D-5npuA:
2.2		 5a06C-5npuA:
undetectable
5a06D-5npuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w75 ELONGATION FACTOR TU

(Thermotoga
neapolitana) 		no annotation 4 ALA A 294
ARG A 234
ALA A 368
GLU A 370
 None
 1.21A 5a06C-5w75A:
2.4
5a06D-5w75A:
2.4		 5a06C-5w75A:
undetectable
5a06D-5w75A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w76 ANCESTRAL ELOGATION
FACTOR N153

(synthetic
construct) 		no annotation 4 ALA A 294
ARG A 234
ALA A 368
GLU A 370
 None
 1.25A 5a06C-5w76A:
3.4
5a06D-5w76A:
2.9		 5a06C-5w76A:
undetectable
5a06D-5w76A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7q CONSENSUS ELONGATION
FACTOR

(synthetic
construct) 		no annotation 4 ALA A 294
ARG A 234
ALA A 368
GLU A 370
 None
 1.42A 5a06C-5w7qA:
3.3
5a06D-5w7qA:
2.9		 5a06C-5w7qA:
undetectable
5a06D-5w7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnn PHOSPHATE-BINDING
PROTEIN PSTS

(Burkholderia
pseudomallei) 		PF12849
(PBP_like_2) 		4 ALA A 300
ARG A 325
ALA A 305
GLU A 321
 None
 1.38A 5a06C-5wnnA:
undetectable
5a06D-5wnnA:
undetectable		 5a06C-5wnnA:
22.66
5a06D-5wnnA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides) 		no annotation 4 ALA A   9
ARG A  41
HIS A  16
ALA A  13
 None
 1.17A 5a06C-5wypA:
undetectable
5a06D-5wypA:
undetectable		 5a06C-5wypA:
undetectable
5a06D-5wypA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1n VANILLATE/3-O-METHYL
GALLATE
O-DEMETHYLASE

(Sphingobium sp.
SYK-6) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 ALA A 377
ARG A  22
ALA A 373
GLU A 425
 None
None
EDO  A 503 ( 4.7A)
None
 1.37A 5a06C-5x1nA:
undetectable
5a06D-5x1nA:
undetectable		 5a06C-5x1nA:
21.40
5a06D-5x1nA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S19E, PUTATIVE

(Trichomonas
vaginalis) 		PF01090
(Ribosomal_S19e) 		4 ALA T  47
ARG T  63
HIS T  99
ALA T  88
 None
G  21289 ( 4.0A)
A  21331 ( 4.2A)
A  21332 ( 4.9A)
 1.18A 5a06C-5xyiT:
undetectable
5a06D-5xyiT:
undetectable		 5a06C-5xyiT:
18.08
5a06D-5xyiT:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a70 -

(-) 		no annotation 4 ALA B3889
ARG B3952
HIS B3697
ALA B3692
 None
 1.24A 5a06C-6a70B:
undetectable
5a06D-6a70B:
undetectable		 5a06C-6a70B:
undetectable
5a06D-6a70B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT B

(Flavobacterium
johnsoniae) 		no annotation 4 ALA B 969
HIS B 137
ALA B 772
GLU B 121
 None
 1.18A 5a06C-6btmB:
undetectable
5a06D-6btmB:
undetectable		 5a06C-6btmB:
undetectable
5a06D-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY

(Thermobifida
fusca) 		no annotation 4 ALA M  40
ARG M  53
ALA M 128
GLU M 121
 A  J   1 ( 4.0A)
None
None
None
 1.47A 5a06C-6c66M:
undetectable
5a06D-6c66M:
undetectable		 5a06C-6c66M:
undetectable
5a06D-6c66M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D

(Pyrococcus
furiosus) 		no annotation 4 ALA H 242
ARG H 371
ALA H 165
GLU H 161
 None
 1.43A 5a06C-6cfwH:
undetectable
5a06D-6cfwH:
undetectable		 5a06C-6cfwH:
undetectable
5a06D-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D

(Pyrococcus
furiosus) 		no annotation 4 ALA H 242
ARG H 371
ALA H 238
GLU H 161
 None
 1.44A 5a06C-6cfwH:
undetectable
5a06D-6cfwH:
undetectable		 5a06C-6cfwH:
undetectable
5a06D-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN

(Chaetomium
thermophilum) 		no annotation 4 ALA H 280
ARG H 241
ALA H 275
GLU H 237
 None
 1.34A 5a06C-6chsH:
undetectable
5a06D-6chsH:
undetectable		 5a06C-6chsH:
undetectable
5a06D-6chsH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd6 PHOTOLYASE PHRB

(Agrobacterium
tumefaciens) 		no annotation 4 ALA A 180
ARG A 305
ALA A 299
GLU A 301
 None
 1.47A 5a06C-6dd6A:
2.5
5a06D-6dd6A:
2.4		 5a06C-6dd6A:
undetectable
5a06D-6dd6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuy VINCULIN

(Homo sapiens) 		no annotation 4 ARG A 502
HIS A 492
ALA A 490
GLU A 498
 None
 1.23A 5a06C-6fuyA:
undetectable
5a06D-6fuyA:
undetectable		 5a06C-6fuyA:
undetectable
5a06D-6fuyA:
undetectable