SIMILAR PATTERNS OF AMINO ACIDS FOR 5A06_D_SORD1342

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ARG B 384
ARG A 464
ASP B 229
TYR B 191
 None
 1.27A 5a06D-1e6vB:
undetectable		 5a06D-1e6vB:
22.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1evj GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		6 LYS A 129
ARG A 157
ARG A 200
ASP A 213
TYR A 217
TYR A 296
 NAD  A 500 (-3.4A)
NAD  A 500 (-3.9A)
NAD  A 500 (-3.0A)
None
None
NAD  A 500 (-4.8A)
 0.27A 5a06D-1evjA:
48.3		 5a06D-1evjA:
49.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE

(Homo sapiens) 		PF00494
(SQS_PSY) 		4 ARG A 218
PHE A 230
ARG A 228
ASP A  84
 None
 1.49A 5a06D-1ezfA:
undetectable		 5a06D-1ezfA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 PHE A 290
ARG A 334
ASP A 312
TYR A 287
 None
 1.33A 5a06D-1ezvA:
undetectable		 5a06D-1ezvA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f7u ARGINYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 ARG A 358
ARG A 270
ASP A 191
TYR A 188
 ARG  A 800 ( 4.6A)
None
None
ARG  A 800 (-4.0A)
 1.50A 5a06D-1f7uA:
2.8		 5a06D-1f7uA:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h6d PRECURSOR FORM OF
GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		6 LYS A 181
ARG A 209
ARG A 252
ASP A 265
TYR A 269
TYR A 348
 GOL  A 600 ( 2.5A)
NDP  A 500 (-4.0A)
NDP  A 500 ( 2.8A)
GOL  A 600 (-2.9A)
GOL  A 600 ( 4.3A)
NDP  A 500 (-4.8A)
 0.38A 5a06D-1h6dA:
48.5		 5a06D-1h6dA:
44.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnt OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		4 PHE A  65
ARG A 332
TYR A  72
TYR A  42
 None
 1.39A 5a06D-1nntA:
undetectable		 5a06D-1nntA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcw CT610

(Chlamydia
trachomatis) 		PF03070
(TENA_THI-4) 		4 LYS A 152
PHE A 214
TYR A  27
TYR A 141
 None
 1.36A 5a06D-1rcwA:
undetectable		 5a06D-1rcwA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE

(Pyrococcus
horikoshii) 		PF08282
(Hydrolase_3) 		4 LYS A  42
ARG A 170
ASP A  10
TYR A  50
 PO4  A 401 ( 4.9A)
None
PO4  A 401 ( 4.6A)
None
 1.45A 5a06D-1wzcA:
5.1		 5a06D-1wzcA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3n ALGQ1

(Sphingomonas
sp. A1) 		PF01547
(SBP_bac_1) 		4 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 MAV  A 495 (-4.1A)
BEM  A 494 ( 4.8A)
None
None
 1.41A 5a06D-1y3nA:
undetectable		 5a06D-1y3nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydw AX110P-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01408
(GFO_IDH_MocA) 		5 LYS A 102
PHE A 162
ARG A 174
ASP A 187
TYR A 191
 None
 1.13A 5a06D-1ydwA:
37.4		 5a06D-1ydwA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydw AX110P-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01408
(GFO_IDH_MocA) 		4 PHE A 243
ARG A 174
ASP A 187
TYR A 191
 None
 1.40A 5a06D-1ydwA:
37.4		 5a06D-1ydwA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc5 GLUTATHIONE
S-TRANSFERASE, MU 7

(Mus musculus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ARG A  25
PHE A 216
ARG A 173
TYR A  14
 None
 1.13A 5a06D-2dc5A:
undetectable		 5a06D-2dc5A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e21 TRNA(ILE)-LYSIDINE
SYNTHASE

(Aquifex
aeolicus) 		PF01171
(ATP_bind_3) 		4 ARG A 113
PHE A 158
ASP A 137
TYR A 114
 ANP  A 500 (-3.0A)
None
None
None
 1.43A 5a06D-2e21A:
undetectable		 5a06D-2e21A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glx 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Ensifer
adhaerens) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LYS A  94
PHE A 232
ARG A 163
ASP A 176
 NDP  A1500 ( 2.9A)
None
NDP  A1500 (-3.0A)
ACT  A1502 ( 3.9A)
 1.22A 5a06D-2glxA:
39.0		 5a06D-2glxA:
29.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 LYS A 635
ARG A 892
PHE A 737
ASP A 735
 None
 1.15A 5a06D-3bgaA:
undetectable		 5a06D-3bgaA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		4 ARG A 402
ARG A 166
TYR A 125
TYR A 430
 None
 1.44A 5a06D-3bolA:
2.0		 5a06D-3bolA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		4 ARG A 197
ARG A  49
ASP A  51
TYR A 201
 None
 1.49A 5a06D-3czeA:
undetectable		 5a06D-3czeA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 LYS A 611
ARG A 868
PHE A 713
ASP A 711
 None
 1.16A 5a06D-3decA:
undetectable		 5a06D-3decA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA
PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens;
Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4)
PF00104
(Hormone_recep)
PF00105
(zf-C4) 		4 PHE A 159
ARG A 202
ASP D 337
TYR A 169
 None
 1.25A 5a06D-3dzuA:
undetectable		 5a06D-3dzuA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1

(Escherichia
coli;
Gallus gallus) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		4 LYS A1083
ARG A1080
ARG A1189
ASP A1181
 A3P  A 673 (-3.3A)
None
None
None
 1.46A 5a06D-3f5fA:
undetectable		 5a06D-3f5fA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8y SUSD/RAGB-ASSOCIATED
ESTERASE-LIKE
PROTEIN

(Bacteroides
vulgatus) 		PF12715
(Abhydrolase_7) 		4 ARG A 287
ARG A 340
ASP A 341
TYR A 387
 None
 1.45A 5a06D-3g8yA:
2.1		 5a06D-3g8yA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyj ALR0039 PROTEIN

(Nostoc sp. PCC
7120) 		PF00561
(Abhydrolase_1) 		4 LYS A  79
ARG A 105
ASP A 210
TYR A 136
 None
 1.43A 5a06D-3qyjA:
4.1		 5a06D-3qyjA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2p RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LYS A 738
ARG A 463
ASP A 461
TYR A 625
 None
 1.47A 5a06D-4a2pA:
undetectable		 5a06D-4a2pA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2q RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		4 LYS A 738
ARG A 463
ASP A 461
TYR A 625
 None
 1.35A 5a06D-4a2qA:
undetectable		 5a06D-4a2qA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aip FE-REGULATED PROTEIN
B

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ARG A 385
ARG A 462
ASP A 464
TYR A 125
 None
 0.91A 5a06D-4aipA:
undetectable		 5a06D-4aipA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aqq L2 PROTEIN III
(PENTON BASE)

(Human
mastadenovirus
B) 		PF01686
(Adeno_Penton_B) 		4 ARG A 460
PHE A 224
ASP A 220
TYR A 242
 None
 1.46A 5a06D-4aqqA:
undetectable		 5a06D-4aqqA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg2 PATF

(Prochloron
didemni) 		no annotation 4 ARG A 239
ASP A 190
TYR A 138
TYR A 300
 None
 1.49A 5a06D-4bg2A:
undetectable		 5a06D-4bg2A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzx BIFUNCTIONAL ENZYME
CYSN/CYSC

(Mycobacterium
tuberculosis) 		PF01583
(APS_kinase) 		4 ARG A 530
ARG A 592
ASP A 550
TYR A 583
 CIT  A1623 (-3.9A)
None
EDO  A1615 ( 4.0A)
EDO  A1615 ( 4.9A)
 1.29A 5a06D-4bzxA:
2.2		 5a06D-4bzxA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk8 HISTIDINOL-PHOSPHATA
SE

(Lactococcus
lactis) 		PF02811
(PHP) 		4 ARG A 160
PHE A  52
ASP A  17
TYR A 157
 GK8  A 305 (-3.0A)
None
ZN  A 302 ( 2.2A)
GK8  A 305 (-4.6A)
 1.40A 5a06D-4gk8A:
undetectable		 5a06D-4gk8A:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h3v OXIDOREDUCTASE
DOMAIN PROTEIN

(Kribbella
flavida) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LYS A 103
ARG A 178
ASP A 191
TYR A 335
 None
 1.15A 5a06D-4h3vA:
36.7		 5a06D-4h3vA:
30.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		4 ARG A 121
PHE A 396
TYR A 206
TYR A 440
 None
 1.27A 5a06D-4mqtA:
undetectable		 5a06D-4mqtA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zd6 HALOHYDRIN EPOXIDASE
B

(Corynebacterium
sp.) 		PF13561
(adh_short_C2) 		4 ARG A 135
PHE A 170
TYR A  19
TYR A 131
 None
CL  A 301 (-4.8A)
None
None
 1.41A 5a06D-4zd6A:
6.4		 5a06D-4zd6A:
23.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a05 ALDOSE-ALDOSE
OXIDOREDUCTASE

(Caulobacter
vibrioides) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		7 LYS A 104
ARG A 132
PHE A 163
ARG A 172
ASP A 185
TYR A 189
TYR A 267
 BGC  A1343 (-2.6A)
NDP  A1340 (-3.7A)
GLC  A1341 ( 3.6A)
NDP  A1340 (-2.8A)
BGC  A1343 ( 3.1A)
BGC  A1343 (-4.2A)
BGC  A1343 (-4.4A)
 0.11A 5a06D-5a05A:
57.5		 5a06D-5a05A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0d SURFACE ANCHORED
PROTEIN

(Clostridium
perfringens) 		PF08341
(TED) 		4 LYS A 111
ARG A 212
TYR A 123
TYR A 193
 None
 1.34A 5a06D-5a0dA:
undetectable		 5a06D-5a0dA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA

(Methanothermobacter
marburgensis;
Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ARG B 383
ARG A 463
ASP B 228
TYR B 190
 None
 1.25A 5a06D-5a8rB:
undetectable		 5a06D-5a8rB:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 ARG A 185
ARG A 620
ASP A 276
TYR A 772
 None
 1.11A 5a06D-5enoA:
undetectable		 5a06D-5enoA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE

(Cupriavidus
metallidurans) 		PF13231
(PMT_2) 		4 LYS A 203
ARG A 270
ASP A 158
TYR A 345
 5TR  A 681 (-4.0A)
5TR  A 681 (-3.5A)
None
5TR  A 681 (-4.5A)
 1.47A 5a06D-5f15A:
2.3		 5a06D-5f15A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h71 ALGQ2

(Sphingomonas
sp.) 		PF01547
(SBP_bac_1) 		4 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 BEM  A 502 ( 4.2A)
MAW  A 501 ( 4.8A)
None
None
 1.39A 5a06D-5h71A:
undetectable		 5a06D-5h71A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqb ALPHA-GLUCOSIDASE

(Pseudoalteromonas
sp. K8) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 ARG A 464
ARG A 594
ASP A 572
TYR A 543
 None
 1.09A 5a06D-5hqbA:
2.3		 5a06D-5hqbA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ht6 HISTONE-LYSINE
N-METHYLTRANSFERASE
2E

(Homo sapiens) 		PF00856
(SET) 		4 ARG A 106
ARG A  95
ASP A  93
TYR A  55
 None
 1.41A 5a06D-5ht6A:
undetectable		 5a06D-5ht6A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2h O-METHYLTRANSFERASE
FAMILY 2

(Planctopirus
limnophila) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 ARG A 274
PHE A 319
ASP A 126
TYR A 327
 None
 1.30A 5a06D-5i2hA:
5.2		 5a06D-5i2hA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv8 LPS BIOSYNTHESIS
PROTEIN

(Klebsiella
pneumoniae) 		PF04453
(OstA_C) 		4 ARG A 381
PHE A 342
ARG A 266
ASP A 294
 None
 1.13A 5a06D-5iv8A:
undetectable		 5a06D-5iv8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv9 LPS-ASSEMBLY PROTEIN
LPTD

(Klebsiella
pneumoniae) 		PF03968
(OstA)
PF04453
(OstA_C) 		4 ARG A 358
PHE A 319
ARG A 243
ASP A 271
 None
 1.32A 5a06D-5iv9A:
undetectable		 5a06D-5iv9A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT

(Methanotorris
formicicus;
Methanotorris
formicicus) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ARG B 384
ARG A 463
ASP B 228
TYR B 190
 None
 1.23A 5a06D-5n28B:
undetectable		 5a06D-5n28B:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN

(Thermoactinomyces
vulgaris) 		PF00668
(Condensation) 		4 ARG A1168
PHE A1014
ASP A1133
TYR A1121
 None
 1.27A 5a06D-5t3eA:
undetectable		 5a06D-5t3eA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj1 DNA TOPOISOMERASE 1

(Mycobacterium
tuberculosis) 		no annotation 4 ARG A 201
ARG A 206
ASP A 209
TYR A 580
 None
 1.34A 5a06D-5uj1A:
2.3		 5a06D-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x55 PROBABLE URACIL-DNA
GLYCOSYLASE

(Acanthamoeba
polyphaga
mimivirus) 		PF03167
(UDG) 		4 ARG A 305
ASP A 281
TYR A 140
TYR A 146
 None
 1.28A 5a06D-5x55A:
undetectable		 5a06D-5x55A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
MEDIUM SUBUNIT
ALDEHYDE OXIDASE
LARGE SUBUNIT

(Methylobacillus
sp. KY4400;
Methylobacillus
sp. KY4400) 		no annotation
no annotation 		4 ARG C 445
PHE B 292
ARG B 321
ASP C 648
 None
 1.44A 5a06D-5y6qC:
undetectable		 5a06D-5y6qC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fk6 RHODOPSIN

(Bos taurus) 		no annotation 4 ARG A 135
PHE A 261
TYR A 223
TYR A 306
 None
BOG  A 407 (-4.6A)
None
None
 1.46A 5a06D-6fk6A:
undetectable		 5a06D-6fk6A:
undetectable