SIMILAR PATTERNS OF AMINO ACIDS FOR 5A06_D_SORD1341

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2r CYTOCHROME C2

(Rhodobacter
capsulatus) 		no annotation 4 LYS A   1
GLU A 105
GLY A 104
GLY A 103
 None
 1.05A 5a06D-1c2rA:
undetectable		 5a06D-1c2rA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqs PROTEIN
(3-DEHYDROQUINATE
SYNTHASE)

(Aspergillus
nidulans) 		PF01761
(DHQ_synthase) 		4 LYS A 357
GLY A 262
GLY A 261
ASP A 257
 None
 1.03A 5a06D-1dqsA:
4.3		 5a06D-1dqsA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanosarcina
barkeri) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 GLU B2407
GLY B2411
GLY B2414
ASP B2415
 None
 0.95A 5a06D-1e6yB:
undetectable		 5a06D-1e6yB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 CYH A 195
GLU A 333
GLY A 331
GLY A 326
ASP A 334
 None
 1.42A 5a06D-1fotA:
undetectable		 5a06D-1fotA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp2 ISOFLAVONE
O-METHYLTRANSFERASE

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		4 CYH A 215
GLY A 196
GLY A 197
ASP A 219
 None
SAH  A1699 (-3.8A)
SAH  A1699 ( 4.2A)
SAH  A1699 (-2.9A)
 0.93A 5a06D-1fp2A:
3.5		 5a06D-1fp2A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2w BETA-LACTAMASE

(Bacillus
licheniformis) 		PF13354
(Beta-lactamase2) 		4 LYS A 149
GLU A 146
GLY A 144
GLY A 143
 None
 0.76A 5a06D-1i2wA:
undetectable		 5a06D-1i2wA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnz SPO0B-ASSOCIATED
GTP-BINDING PROTEIN

(Bacillus
subtilis) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		4 GLU A 144
GLY A 146
GLY A  13
ASP A  14
 None
 0.97A 5a06D-1lnzA:
3.4		 5a06D-1lnzA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpl HYPOTHETICAL 25.4
KDA PROTEIN F53F4.3
IN CHROMOSOME V

(Caenorhabditis
elegans) 		PF01302
(CAP_GLY) 		4 CYH A 203
GLU A 165
GLY A 164
ASP A 185
 None
 1.02A 5a06D-1lplA:
undetectable		 5a06D-1lplA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzk HEROIN ESTERASE

(Rhodococcus sp.) 		PF07859
(Abhydrolase_3) 		4 CYH A 102
GLU A 187
GLY A 158
GLY A 157
 None
 0.95A 5a06D-1lzkA:
3.4		 5a06D-1lzkA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE

(Bacillus
subtilis) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 GLU X 111
GLY X 117
GLY X 116
ASP X  98
 G6P  X 902 ( 2.7A)
None
None
None
 0.98A 5a06D-1u8xX:
7.5		 5a06D-1u8xX:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE

(Bacillus
coagulans) 		PF00180
(Iso_dh) 		4 GLU A  89
GLY A  44
GLY A  45
ASP A  11
 None
 0.85A 5a06D-1v5bA:
undetectable		 5a06D-1v5bA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00180
(Iso_dh) 		4 GLU A  87
GLY A  42
GLY A  43
ASP A   9
 None
 1.00A 5a06D-1vlcA:
undetectable		 5a06D-1vlcA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y25 PROBABLE THIOL
PEROXIDASE

(Mycobacterium
tuberculosis) 		PF08534
(Redoxin) 		4 CYH A  93
GLY A  31
GLY A  32
ASP A  33
 None
 0.87A 5a06D-1y25A:
undetectable		 5a06D-1y25A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN

(Pseudomonas
aeruginosa) 		PF04958
(AstA) 		4 GLU A 163
GLY A 257
GLY A 256
ASP A 255
 CA  A 701 (-3.3A)
None
None
CA  A 701 ( 4.3A)
 0.89A 5a06D-1yleA:
undetectable		 5a06D-1yleA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		4 CYH A  38
GLY A  18
GLY A  19
ASP A  42
 None
NAD  A 703 (-3.4A)
None
NAD  A 703 (-2.7A)
 0.97A 5a06D-1z45A:
7.4		 5a06D-1z45A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zef ALKALINE PHOSPHATASE

(Homo sapiens) 		PF00245
(Alk_phosphatase) 		4 LYS A 275
GLU A 270
GLY A 202
GLY A 201
 None
CA  A 904 (-3.1A)
None
None
 0.94A 5a06D-1zefA:
undetectable		 5a06D-1zefA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE

(Legionella
pneumophila) 		PF05761
(5_nucleotid) 		4 CYH A 316
GLY A 294
GLY A 295
ASP A 296
 None
 0.98A 5a06D-2bdeA:
undetectable		 5a06D-2bdeA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c45 ASPARTATE
1-DECARBOXYLASE
PRECURSOR

(Mycobacterium
tuberculosis) 		PF02261
(Asp_decarbox) 		4 GLU A  63
GLY A  65
GLY A  67
ASP A  29
 None
 0.90A 5a06D-2c45A:
undetectable		 5a06D-2c45A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		4 LYS A 352
GLU A 349
GLY A 347
GLY A 346
 None
 0.91A 5a06D-2ctzA:
undetectable		 5a06D-2ctzA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3i OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		4 LYS A 624
GLU A 621
GLY A 619
GLY A 616
 None
 0.98A 5a06D-2d3iA:
undetectable		 5a06D-2d3iA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dba SMOOTH MUSCLE CELL
ASSOCIATED
PROTEIN-1, ISOFORM 2

(Homo sapiens) 		PF07719
(TPR_2)
PF13432
(TPR_16) 		4 LYS A 100
GLY A  97
GLY A  96
ASP A  95
 None
 0.83A 5a06D-2dbaA:
undetectable		 5a06D-2dbaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES

(Escherichia
coli) 		PF07995
(GSDH) 		4 GLU A 212
GLY A 214
GLY A 218
ASP A 219
 EDO  A3002 (-3.3A)
EDO  A3002 (-3.6A)
None
None
 0.81A 5a06D-2g8sA:
undetectable		 5a06D-2g8sA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0s AROMATIC AMINE
DEHYDROGENASE

(Alcaligenes
faecalis) 		PF06433
(Me-amine-dh_H) 		4 GLU A 254
GLY A 253
GLY A 256
ASP A 255
 None
 1.03A 5a06D-2i0sA:
undetectable		 5a06D-2i0sA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 GLU A 214
GLY A 231
GLY A 232
ASP A 233
 None
 0.73A 5a06D-2jgdA:
2.1		 5a06D-2jgdA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 GLU A 230
GLY A 231
GLY A 232
ASP A 233
 None
 1.05A 5a06D-2jgdA:
2.1		 5a06D-2jgdA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kpk MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00595
(PDZ) 		4 LYS A   1
GLU A  36
GLY A  34
GLY A  33
 None
 0.88A 5a06D-2kpkA:
undetectable		 5a06D-2kpkA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lxn GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A

(Methanocaldococcus
jannaschii) 		PF00117
(GATase) 		4 CYH A  76
GLY A   8
GLY A   9
ASP A   6
 None
 0.74A 5a06D-2lxnA:
4.2		 5a06D-2lxnA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		4 CYH C 251
GLY C 207
GLY C 221
ASP C 223
 None
 0.93A 5a06D-2nymC:
undetectable		 5a06D-2nymC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 CYH A  40
GLY A  44
GLY A  45
ASP A  97
 None
 0.77A 5a06D-2qo3A:
undetectable		 5a06D-2qo3A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyo O-METHYLTRANSFERASE

(Medicago
truncatula) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		4 CYH A 220
GLY A 201
GLY A 202
ASP A 224
 None
SAH  A 601 (-3.7A)
SAH  A 601 ( 4.3A)
SAH  A 601 (-2.9A)
 0.89A 5a06D-2qyoA:
4.9		 5a06D-2qyoA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vq5 S-NORCOCLAURINE
SYNTHASE

(Thalictrum
flavum) 		PF00407
(Bet_v_1) 		4 LYS A 111
GLY A  90
GLY A  89
ASP A  88
 None
 0.69A 5a06D-2vq5A:
undetectable		 5a06D-2vq5A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvg PYRUVATE
DECARBOXYLASE

(Zymomonas
mobilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 CYH A 537
GLU A 517
GLY A 516
GLY A 515
 None
 1.02A 5a06D-2wvgA:
2.7		 5a06D-2wvgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe5 OUTER MEMBRANE PORIN
C

(Escherichia
coli) 		PF00267
(Porin_1) 		4 GLU A 109
GLY A 111
GLY A 112
ASP A 113
 None
 0.94A 5a06D-2xe5A:
undetectable		 5a06D-2xe5A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1

(Homo sapiens) 		PF01026
(TatD_DNase) 		4 CYH A  81
GLU A 112
GLY A 111
GLY A  75
 None
EDO  A1299 (-3.9A)
None
None
 0.97A 5a06D-2xioA:
2.6		 5a06D-2xioA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb7 INTERPAIN A

(Prevotella
intermedia) 		PF01640
(Peptidase_C10)
PF13734
(Inhibitor_I69) 		4 GLU A 348
GLY A 293
GLY A 292
ASP A 350
 None
 1.00A 5a06D-3bb7A:
undetectable		 5a06D-3bb7A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d46 PUTATIVE GALACTONATE
DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 CYH A 397
GLU A  24
GLY A  26
GLY A  28
ASP A  34
 None
 1.43A 5a06D-3d46A:
undetectable		 5a06D-3d46A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dez OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Streptococcus
mutans) 		PF00156
(Pribosyltran) 		4 LYS A  20
GLU A  22
GLY A 193
ASP A 190
 None
 1.04A 5a06D-3dezA:
undetectable		 5a06D-3dezA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 CYH A 113
LYS A 115
GLY A 369
GLY A 366
 None
 1.03A 5a06D-3dtyA:
33.2		 5a06D-3dtyA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fh3 PUTATIVE ECF-TYPE
SIGMA FACTOR
NEGATIVE EFFECTOR

(Bacillus
anthracis) 		PF12207
(DUF3600) 		4 GLU A 122
GLY A  67
GLY A  63
ASP A  64
 None
 0.97A 5a06D-3fh3A:
undetectable		 5a06D-3fh3A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN REGULATORY
LIGHT CHAIN LC-2,
MANTLE MUSCLE

(Todarodes
pacificus) 		PF13405
(EF-hand_6) 		4 LYS B  39
GLU B  36
GLY B  34
ASP B  28
 None
 1.02A 5a06D-3i5gB:
undetectable		 5a06D-3i5gB:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie5 PHENOLIC OXIDATIVE
COUPLING PROTEIN
HYP-1

(Hypericum
perforatum) 		PF00407
(Bet_v_1) 		4 LYS A  71
GLY A  50
GLY A  49
ASP A  48
 PG4  A 508 (-2.8A)
None
None
None
 0.69A 5a06D-3ie5A:
undetectable		 5a06D-3ie5A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Cytophaga
hutchinsonii) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 CYH A  98
LYS A 106
GLU A 101
GLY A 103
 None
 0.90A 5a06D-3ilvA:
undetectable		 5a06D-3ilvA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n11 CHITINASE A

(Bacillus cereus) 		PF00704
(Glyco_hydro_18) 		4 GLU A  77
GLY A  70
GLY A  71
ASP A  72
 None
 1.05A 5a06D-3n11A:
undetectable		 5a06D-3n11A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nec INFLAMMATORY
PROFILIN

(Toxoplasma
gondii) 		PF00235
(Profilin) 		4 GLU A  57
GLY A  56
GLY A  59
ASP A  58
 None
 1.03A 5a06D-3necA:
undetectable		 5a06D-3necA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nip 3-GUANIDINOPROPIONAS
E

(Pseudomonas
aeruginosa) 		PF00491
(Arginase) 		4 GLU A  60
GLY A 293
GLY A 292
ASP A 290
 None
 0.85A 5a06D-3nipA:
2.5		 5a06D-3nipA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 LYS A 211
GLY A 140
GLY A 141
ASP A 142
 None
 0.93A 5a06D-3oneA:
4.2		 5a06D-3oneA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT
PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli;
Escherichia
coli) 		PF01409
(tRNA-synt_2d)
PF02912
(Phe_tRNA-synt_N)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 LYS B 499
GLU B 509
GLY A 105
GLY A 104
 None
 1.04A 5a06D-3pcoB:
undetectable		 5a06D-3pcoB:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt5 NANS (YJHS), A
9-O-ACETYL
N-ACETYLNEURAMINIC
ACID ESTERASE

(Escherichia
coli) 		PF03629
(SASA) 		4 GLU A  26
GLY A  27
GLY A 284
ASP A 274
 None
 0.95A 5a06D-3pt5A:
3.8		 5a06D-3pt5A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q62 3-HYDROXYDECANOYL-[A
CYL-CARRIER-PROTEIN]
DEHYDRATASE

(Yersinia pestis) 		PF07977
(FabA) 		4 LYS A  -2
GLU A 101
GLY A  26
GLY A  23
 None
 0.93A 5a06D-3q62A:
undetectable		 5a06D-3q62A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u58 TETRAHYMENA TEB1 AB

(Tetrahymena
thermophila) 		PF01336
(tRNA_anti-codon) 		4 LYS A 302
GLU A 289
GLY A 288
GLY A 287
 None
 0.87A 5a06D-3u58A:
undetectable		 5a06D-3u58A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up4 OTEMO

(Pseudomonas
putida) 		PF00743
(FMO-like) 		4 CYH A 531
LYS A 529
GLU A 526
GLY A 524
 None
 0.98A 5a06D-3up4A:
2.4		 5a06D-3up4A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 LYS A  57
GLY A  54
GLY A  53
ASP A  52
 None
 0.80A 5a06D-3uyqA:
undetectable		 5a06D-3uyqA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1

(Yersinia pestis) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		4 GLU A 199
GLY A 198
GLY A 197
ASP A 246
 None
 0.90A 5a06D-3zu4A:
5.3		 5a06D-3zu4A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 LYS A1217
GLU A1215
GLY A 742
GLY A 743
 None
 0.93A 5a06D-3zyvA:
2.2		 5a06D-3zyvA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 GLU A 517
GLY A 519
GLY A 521
ASP A 561
 None
 1.03A 5a06D-3zzuA:
3.6		 5a06D-3zzuA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aov ISOCITRATE
DEHYDROGENASE [NADP]

(Desulfotalea
psychrophila) 		PF00180
(Iso_dh) 		4 GLU A  46
GLY A  44
GLY A  14
ASP A  15
 None
 0.94A 5a06D-4aovA:
undetectable		 5a06D-4aovA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bko PUTATIVE REDUCTASE
BURPS305_1051

(Burkholderia
pseudomallei) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		4 GLU A 199
GLY A 198
GLY A 197
ASP A 246
 None
 0.82A 5a06D-4bkoA:
5.4		 5a06D-4bkoA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cok PYRUVATE
DECARBOXYLASE

(Gluconacetobacter
diazotrophicus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 CYH A 529
GLU A 509
GLY A 508
GLY A 507
 None
 1.01A 5a06D-4cokA:
3.6		 5a06D-4cokA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00701
(DHDPS) 		4 LYS A  73
GLU A 110
GLY A 105
GLY A 106
 None
 1.04A 5a06D-4dppA:
2.5		 5a06D-4dppA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gn2 OXACILLINASE

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase) 		4 LYS A 149
GLU A 146
GLY A 145
GLY A 152
 None
 0.97A 5a06D-4gn2A:
undetectable		 5a06D-4gn2A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4haq GH7 FAMILY PROTEIN

(Limnoria
quadripunctata) 		PF00840
(Glyco_hydro_7) 		4 GLU A 296
GLY A 297
GLY A 298
ASP A 301
 None
 0.79A 5a06D-4haqA:
undetectable		 5a06D-4haqA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00180
(Iso_dh) 		4 GLU A  83
GLY A  38
GLY A  39
ASP A   9
 None
 1.03A 5a06D-4iwhA:
undetectable		 5a06D-4iwhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnj STREPTAVIDIN/RHIZAVI
DIN HYBRID

(Streptomyces
avidinii) 		PF01382
(Avidin) 		4 LYS A  12
GLY A  34
GLY A  37
ASP A  36
 ZN  A 203 ( 3.8A)
ZN  A 204 ( 4.9A)
None
ZN  A 204 (-2.6A)
 0.93A 5a06D-4jnjA:
undetectable		 5a06D-4jnjA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mje PROBABLE
GLUTAREDOXIN SSR2061

(Synechocystis
sp. PCC 6803) 		PF00462
(Glutaredoxin) 		4 LYS A  65
GLY A  79
GLY A  80
ASP A  83
 None
None
SO4  A 102 (-3.5A)
None
 0.92A 5a06D-4mjeA:
undetectable		 5a06D-4mjeA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0k PHYTOHORMONE BINDING
PROTEIN MTPHBP

(Medicago
truncatula) 		PF00407
(Bet_v_1) 		4 LYS A  53
GLY A  49
GLY A  48
ASP A  47
 None
GOL  A 203 (-3.5A)
GOL  A 204 (-3.6A)
GOL  A 203 (-3.0A)
 0.87A 5a06D-4q0kA:
undetectable		 5a06D-4q0kA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvc DEXTRANSUCRASE

(Leuconostoc
mesenteroides) 		PF02324
(Glyco_hydro_70) 		4 LYS A2793
GLY A2733
GLY A2732
ASP A2654
 None
 0.90A 5a06D-4tvcA:
undetectable		 5a06D-4tvcA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9s NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C

(Vibrio cholerae) 		PF04205
(FMN_bind) 		4 LYS C 135
GLU C 156
GLY C 159
ASP C 158
 None
 1.05A 5a06D-4u9sC:
undetectable		 5a06D-4u9sC:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF13407
(Peripla_BP_4) 		4 GLU A 346
GLY A 344
GLY A 343
ASP A 342
 None
None
None
EDO  A 402 ( 4.2A)
 0.90A 5a06D-4wzzA:
3.9		 5a06D-4wzzA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yqy PUTATIVE
DEHYDROGENASE

(Sulfitobacter
sp. NAS-14.1) 		PF13561
(adh_short_C2) 		4 LYS A 159
GLY A 148
GLY A 147
ASP A 146
 None
 0.93A 5a06D-4yqyA:
4.8		 5a06D-4yqyA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zb1 BLUE CHROMOPROTEIN,
SGBP

(Stichodactyla
gigantea) 		PF01353
(GFP) 		4 LYS A  24
GLU A  46
GLY A  47
GLY A  48
 None
 1.05A 5a06D-4zb1A:
undetectable		 5a06D-4zb1A:
22.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a05 ALDOSE-ALDOSE
OXIDOREDUCTASE

(Caulobacter
vibrioides) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 CYH A 120
LYS A 126
GLY A 313
GLY A 314
ASP A 315
 None
 0.22A 5a06D-5a05A:
57.5		 5a06D-5a05A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a05 ALDOSE-ALDOSE
OXIDOREDUCTASE

(Caulobacter
vibrioides) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 GLU A 309
GLY A 313
GLY A 314
ASP A 315
 None
 1.02A 5a06D-5a05A:
57.5		 5a06D-5a05A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0t RIBONUCLEASE J

(Streptomyces
coelicolor) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		4 GLU A  29
GLY A  26
GLY A  25
ASP A 427
 None
 0.85A 5a06D-5a0tA:
undetectable		 5a06D-5a0tA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus musculus) 		PF00069
(Pkinase) 		4 GLU A 214
GLY A 213
GLY A 216
ASP A 215
 None
 0.95A 5a06D-5dbxA:
undetectable		 5a06D-5dbxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm6 50S RIBOSOMAL
PROTEIN L19

(Deinococcus
radiodurans) 		PF01245
(Ribosomal_L19) 		4 GLU M  95
GLY M  97
GLY M  30
ASP M  31
 None
 0.79A 5a06D-5dm6M:
undetectable		 5a06D-5dm6M:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 GLU A 379
GLY A 358
GLY A 357
ASP A 196
 None
 0.99A 5a06D-5fl7A:
undetectable		 5a06D-5fl7A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE
CHITINASE

(Paenibacillus
sp. FPU-7;
Paenibacillus
sp. FPU-7) 		no annotation
PF00704
(Glyco_hydro_18) 		4 LYS B 299
GLU A 256
GLY A 278
GLY A 279
 None
 0.86A 5a06D-5gztB:
undetectable		 5a06D-5gztB:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		4 LYS A  73
GLY A  24
GLY A  25
ASP A  26
 None
 0.88A 5a06D-5h42A:
undetectable		 5a06D-5h42A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kol UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		PF02464
(CinA) 		4 GLU A 123
GLY A 122
GLY A 125
ASP A 124
 None
 0.87A 5a06D-5kolA:
undetectable		 5a06D-5kolA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum) 		PF02353
(CMAS) 		4 CYH A 233
GLU A 345
GLY A 343
GLY A 285
 None
 0.98A 5a06D-5kpgA:
2.8		 5a06D-5kpgA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3r SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN,
CHLOROPLASTIC
CELL DIVISION
PROTEIN FTSY
HOMOLOG,
CHLOROPLASTIC

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF00448
(SRP54)
PF02881
(SRP54_N) 		4 GLU A 303
GLY A 301
GLY B 296
ASP B 108
 None
 0.87A 5a06D-5l3rA:
2.6		 5a06D-5l3rA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lda JAMM1
SAMP2

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		PF14464
(Prok-JAB)
PF02597
(ThiS) 		4 CYH A  36
GLY B  69
GLY B  68
ASP A 101
 None
ZN  A 201 (-3.9A)
None
ZN  A 201 (-2.2A)
 1.05A 5a06D-5ldaA:
undetectable		 5a06D-5ldaA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf2 LAMININ SUBUNIT
BETA-2

(Rattus
norvegicus) 		PF00053
(Laminin_EGF) 		4 GLU A 731
GLY A 735
GLY A 736
ASP A 737
 None
 0.84A 5a06D-5lf2A:
undetectable		 5a06D-5lf2A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lo9 CYTOCHROME C

(Marichromatium
purpuratum) 		PF00034
(Cytochrom_C)
PF13442
(Cytochrome_CBB3) 		4 CYH A  21
GLY A  30
GLY A  29
ASP A  28
 HEC  A1001 (-1.7A)
None
None
None
 0.90A 5a06D-5lo9A:
undetectable		 5a06D-5lo9A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5non S-NORCOCLAURINE
SYNTHASE

(Thalictrum
flavum) 		PF00407
(Bet_v_1) 		4 LYS A 111
GLY A  90
GLY A  89
ASP A  88
 None
 0.65A 5a06D-5nonA:
undetectable		 5a06D-5nonA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1

(Saccharomyces
cerevisiae) 		PF12231
(Rif1_N) 		4 LYS A 214
GLU A 218
GLY A 219
GLY A 220
 None
 0.76A 5a06D-5nvrA:
undetectable		 5a06D-5nvrA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szn PROTOCADHERIN GAMMA
A9

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 GLU A 294
GLY A 297
GLY A 296
ASP A 295
 None
None
None
CA  A 607 (-3.6A)
 0.86A 5a06D-5sznA:
undetectable		 5a06D-5sznA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzb D-AMINOPEPTIDASE

(Burkholderia
sp. LK4) 		PF03576
(Peptidase_S58) 		4 CYH A 171
GLU A 274
GLY A 271
GLY A 270
 None
 0.92A 5a06D-5tzbA:
undetectable		 5a06D-5tzbA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE

(Neurospora
crassa) 		no annotation 4 LYS C 339
GLU C 343
GLY C 344
GLY C 345
 None
 1.02A 5a06D-5v12C:
undetectable		 5a06D-5v12C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vi6 HISTONE DEACETYLASE
8

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		4 LYS A  33
GLY A 304
GLY A 305
ASP A 267
 None
ZN  A 401 ( 4.2A)
None
ZN  A 401 (-2.4A)
 0.85A 5a06D-5vi6A:
undetectable		 5a06D-5vi6A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm8 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Neisseria
gonorrhoeae) 		PF04452
(Methyltrans_RNA) 		4 CYH A 136
GLY A  44
GLY A  42
ASP A  41
 None
 0.93A 5a06D-5vm8A:
2.8		 5a06D-5vm8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vu3 COMPETENCE
DAMAGE-INDUCIBLE
PROTEIN A

(Enterobacter
cloacae) 		PF02464
(CinA) 		4 GLU A 119
GLY A 118
GLY A 121
ASP A 120
 None
 1.04A 5a06D-5vu3A:
undetectable		 5a06D-5vu3A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whs CATALASE-PEROXIDASE

(Neurospora
crassa) 		no annotation 4 GLU A 107
GLY A 105
GLY A 104
ASP A 427
 None
 0.81A 5a06D-5whsA:
undetectable		 5a06D-5whsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfo PHD FINGER PROTEIN 1

(Homo sapiens) 		PF00628
(PHD) 		4 LYS A 164
GLU A 242
GLY A 240
GLY A 239
 None
 0.99A 5a06D-5xfoA:
undetectable		 5a06D-5xfoA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4g AMBP3

(Fischerella
ambigua) 		no annotation 4 LYS A  37
GLU A  63
GLY A  62
GLY A  42
 None
 0.87A 5a06D-5y4gA:
undetectable		 5a06D-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM

(Geobacillus
stearothermophilus) 		no annotation 4 GLU A 163
GLY A 165
GLY A 100
ASP A 101
 None
 0.92A 5a06D-5yhhA:
undetectable		 5a06D-5yhhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5d BETA-XYLOSIDASE

(Geobacillus
thermoleovorans) 		no annotation 4 LYS A  95
GLY A 118
GLY A 119
ASP A 139
 None
 1.00A 5a06D-5z5dA:
undetectable		 5a06D-5z5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9m E3 UBIQUITIN-PROTEIN
LIGASE UHRF1

(Danio rerio) 		no annotation 4 GLU A 173
GLY A 170
GLY A 169
ASP A 168
 None
 0.84A 5a06D-6b9mA:
undetectable		 5a06D-6b9mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE

(Klebsiella
pneumoniae) 		no annotation 4 GLU A 109
GLY A 115
GLY A 114
ASP A  96
 NAD  A 501 (-2.9A)
None
None
None
 0.98A 5a06D-6duxA:
6.9		 5a06D-6duxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gkv COCLAURINE
N-METHYLTRANSFERASE

(Coptis japonica) 		no annotation 4 CYH A 235
GLU A 347
GLY A 345
GLY A 287
 None
 1.01A 5a06D-6gkvA:
3.1		 5a06D-6gkvA:
undetectable