SIMILAR PATTERNS OF AMINO ACIDS FOR 5A06_B_SORB1342

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aow ANNEXIN IV

(Bos taurus) 		PF00191
(Annexin) 		4 ILE A 120
GLU A 161
GLY A 158
GLY A 157
 None
 0.72A 5a06B-1aowA:
undetectable		 5a06B-1aowA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg5 FUSION PROTEIN OF
ALPHA-NA,K-ATPASE
WITH GLUTATHIONE
S-TRANSFERASE

(Rattus
norvegicus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ILE A  92
LYS A  87
GLY A  84
GLY A  83
 None
 0.74A 5a06B-1bg5A:
undetectable		 5a06B-1bg5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 ILE A 181
CYH A 166
GLY A 179
GLY A 180
 None
 0.83A 5a06B-1c30A:
2.1		 5a06B-1c30A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e09 PRU AV 1

(Prunus avium) 		PF00407
(Bet_v_1) 		4 ILE A  43
LYS A  70
GLY A  49
GLY A  48
 None
 0.72A 5a06B-1e09A:
undetectable		 5a06B-1e09A:
19.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1evj GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ILE A 142
LYS A 151
LEU A 152
GLY A 346
 None
 0.29A 5a06B-1evjA:
48.5		 5a06B-1evjA:
49.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h6d PRECURSOR FORM OF
GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ILE A 194
LYS A 203
LEU A 204
GLY A 398
 None
 0.19A 5a06B-1h6dA:
48.6		 5a06B-1h6dA:
44.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Trypanosoma
cruzi) 		PF01293
(PEPCK_ATP) 		4 ILE A 126
CYH A  96
GLY A 257
GLY A 256
 None
 0.83A 5a06B-1ii2A:
undetectable		 5a06B-1ii2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ILE A 105
LEU A  49
GLY A  46
GLY A  45
 None
None
FAD  A 480 (-3.1A)
None
 0.80A 5a06B-1lpfA:
undetectable		 5a06B-1lpfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH) 		4 ILE A  77
LEU A  71
GLY A  75
GLY A  76
 None
 0.85A 5a06B-1lrtA:
1.5		 5a06B-1lrtA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 ILE A  77
LEU A  71
GLY A  75
GLY A  76
 None
 0.84A 5a06B-1mewA:
0.8		 5a06B-1mewA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE

(Arabidopsis
thaliana) 		PF16363
(GDP_Man_Dehyd) 		4 ILE A  33
LEU A 113
GLY A  38
GLY A  41
 None
NDP  A 701 (-4.3A)
NDP  A 701 (-3.3A)
None
 0.87A 5a06B-1n7gA:
6.1		 5a06B-1n7gA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1np3 KETOL-ACID
REDUCTOISOMERASE

(Pseudomonas
aeruginosa) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 ILE A  21
LEU A  79
GLY A  25
GLY A  28
 None
 0.73A 5a06B-1np3A:
7.2		 5a06B-1np3A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Geobacillus
stearothermophilus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 ILE A 483
LEU A  45
GLY A 481
GLY A 482
 None
 0.83A 5a06B-1o99A:
undetectable		 5a06B-1o99A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orr CDP-TYVELOSE-2-EPIME
RASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		4 ILE A   6
LEU A  80
GLY A  11
GLY A  14
 None
NAD  A1200 (-4.4A)
NAD  A1200 (-3.1A)
None
 0.83A 5a06B-1orrA:
6.6		 5a06B-1orrA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		4 ILE A 565
CYH A 568
LEU A 575
GLY A 606
 None
 0.74A 5a06B-1qb4A:
undetectable		 5a06B-1qb4A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE

(Mus musculus) 		PF02348
(CTP_transf_3) 		5 ILE A  95
LYS A  59
LEU A  58
GLY A  52
GLY A  51
 None
 0.97A 5a06B-1qwjA:
2.9		 5a06B-1qwjA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh9 ENDO-BETA-MANNANASE

(Solanum
lycopersicum) 		PF00150
(Cellulase) 		4 ILE A 316
LEU A 315
GLY A 355
GLY A 356
 None
 0.79A 5a06B-1rh9A:
undetectable		 5a06B-1rh9A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		4 ILE A1348
LEU A1306
GLY A1352
GLY A1353
 None
 0.77A 5a06B-1ug3A:
undetectable		 5a06B-1ug3A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00180
(Iso_dh) 		4 ILE A  41
LEU A  53
GLY A  89
GLY A  90
 None
 0.71A 5a06B-1vlcA:
undetectable		 5a06B-1vlcA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Thermotoga
maritima) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 ILE A  63
LEU A  57
GLY A  61
GLY A  62
 None
 0.85A 5a06B-1vrdA:
2.7		 5a06B-1vrdA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxl SINGLE-STRAND
RECOGNITION PROTEIN

(Drosophila
melanogaster) 		PF00505
(HMG_box) 		4 ILE A  23
LEU A  16
GLY A  40
GLY A  39
 None
 0.84A 5a06B-1wxlA:
undetectable		 5a06B-1wxlA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		4 ILE A 200
LEU A 203
GLY A 189
GLY A 190
 None
 0.67A 5a06B-1wy0A:
undetectable		 5a06B-1wy0A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		4 ILE A 320
LEU A 389
GLY A 325
GLY A 328
 None
None
ATP  A1001 (-2.9A)
None
 0.77A 5a06B-1z7eA:
8.1		 5a06B-1z7eA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Thermotoga
maritima) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 ILE A 255
LEU A 274
GLY A 253
GLY A 254
 None
 0.76A 5a06B-1zczA:
4.4		 5a06B-1zczA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ILE A 103
LEU A  46
GLY A  43
GLY A  42
 None
None
FAD  A4750 (-2.7A)
None
 0.84A 5a06B-1zy8A:
undetectable		 5a06B-1zy8A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ash QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Thermotoga
maritima) 		PF01702
(TGT) 		4 ILE A 214
LEU A 212
GLY A 210
GLY A 211
 EDO  A 404 (-4.0A)
None
EDO  A 404 (-3.4A)
EDO  A 404 (-3.0A)
 0.82A 5a06B-2ashA:
undetectable		 5a06B-2ashA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE

(Enterococcus
faecalis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 ILE A   5
LEU A  78
GLY A   9
GLY A  12
 None
 0.81A 5a06B-2ew2A:
7.2		 5a06B-2ew2A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 LEU A 171
GLU A  40
GLY A 175
GLY A 176
 None
NAD  A5555 ( 4.8A)
NAD  A5555 (-3.7A)
None
 0.83A 5a06B-2fknA:
undetectable		 5a06B-2fknA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 CYH A  84
LEU A  86
GLY A  88
GLY A  89
 None
 0.80A 5a06B-2gepA:
undetectable		 5a06B-2gepA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu4 DIHYDROXYACETONE
KINASE

(Lactococcus
lactis) 		PF02733
(Dak1) 		4 ILE A  10
GLU A  55
GLY A  51
GLY A  73
 None
None
HIQ  A 215 ( 3.1A)
None
 0.77A 5a06B-2iu4A:
2.9		 5a06B-2iu4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkg ACETYLCHOLINE
RECEPTOR

(Torpedo
marmorata) 		PF02932
(Neur_chan_memb) 		4 ILE A 102
GLU A  38
GLY A  44
GLY A  45
 None
 0.77A 5a06B-2lkgA:
undetectable		 5a06B-2lkgA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqa CALPAIN 8

(Homo sapiens) 		PF00648
(Peptidase_C2) 		4 LEU A 166
GLU A 182
GLY A 100
GLY A 101
 None
None
CSO  A  98 ( 4.5A)
None
 0.83A 5a06B-2nqaA:
undetectable		 5a06B-2nqaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3f PUTATIVE HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YBBH

(Bacillus
subtilis) 		PF01418
(HTH_6) 		4 ILE A   9
LEU A   6
GLY A   4
GLY A   5
 None
 0.85A 5a06B-2o3fA:
undetectable		 5a06B-2o3fA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogf HYPOTHETICAL PROTEIN
MJ0408

(Methanocaldococcus
jannaschii) 		PF04038
(DHNA) 		4 ILE A  92
LEU A 101
GLY A  27
GLY A  26
 None
 0.85A 5a06B-2ogfA:
2.3		 5a06B-2ogfA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okk GLUTAMATE
DECARBOXYLASE 2

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 LYS A 378
LEU A 371
GLY A 369
GLY A 370
 None
 0.80A 5a06B-2okkA:
undetectable		 5a06B-2okkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		4 LYS A 228
LEU A  43
GLY A  45
GLY A  44
 None
 0.83A 5a06B-2ozoA:
undetectable		 5a06B-2ozoA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p24 H-2 CLASS II
HISTOCOMPATIBILITY
ANTIGEN, A-U ALPHA
CHAIN

(Mus musculus) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		4 ILE A  63
LEU A  60
GLY A  58
GLY A  59
 None
 0.85A 5a06B-2p24A:
undetectable		 5a06B-2p24A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph5 HOMOSPERMIDINE
SYNTHASE

(Legionella
pneumophila) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 ILE A 426
LEU A 162
GLU A 295
GLY A 157
 None
None
None
NAD  A 501 (-3.0A)
 0.82A 5a06B-2ph5A:
5.7		 5a06B-2ph5A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk3 GDP-6-DEOXY-D-LYXO-4
-HEXULOSE REDUCTASE

(Aneurinibacillus
thermoaerophilus) 		PF16363
(GDP_Man_Dehyd) 		4 ILE A   5
LEU A  69
GLY A  10
GLY A  13
 None
A2R  A 401 (-4.2A)
A2R  A 401 (-3.3A)
None
 0.87A 5a06B-2pk3A:
5.0		 5a06B-2pk3A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v28 PHENYLALANINE-4-HYDR
OXYLASE

(Colwellia
psychrerythraea) 		PF00351
(Biopterin_H) 		4 ILE A 179
CYH A  44
GLY A 182
GLY A 181
 None
 0.81A 5a06B-2v28A:
undetectable		 5a06B-2v28A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 LEU A 175
GLU A  44
GLY A 179
GLY A 180
 None
NAD  A3001 (-4.6A)
NAD  A3001 (-3.7A)
None
 0.80A 5a06B-2v7gA:
undetectable		 5a06B-2v7gA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8j PECTATE LYASE

(Yersinia
enterocolitica) 		PF06917
(Pectate_lyase_2) 		4 LYS A 132
LEU A 131
GLY A 108
GLY A 107
 None
 0.70A 5a06B-2v8jA:
undetectable		 5a06B-2v8jA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vw8 PA1000

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 ILE A  41
LEU A  77
GLY A  39
GLY A  40
 None
 0.81A 5a06B-2vw8A:
undetectable		 5a06B-2vw8A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvg PYRUVATE
DECARBOXYLASE

(Zymomonas
mobilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 CYH A 537
LEU A 518
GLY A 516
GLY A 515
 None
 0.83A 5a06B-2wvgA:
2.5		 5a06B-2wvgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsx BETA-ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 LYS A 162
LEU A 163
GLY A 156
GLY A 155
 None
 0.68A 5a06B-2xsxA:
undetectable		 5a06B-2xsxA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfh GLUTAMATE
DEHYDROGENASE,
NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE,
GLUTAMATE
DEHYDROGENASE

(Escherichia
coli;
[Clostridium]
symbiosum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ILE A  86
GLU A  56
GLY A 124
GLY A 123
 None
 0.86A 5a06B-2yfhA:
3.2		 5a06B-2yfhA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z95 GDP-D-MANNOSE
DEHYDRATASE

(Aquifex
aeolicus) 		PF16363
(GDP_Man_Dehyd) 		4 ILE A   8
LEU A  82
GLY A  13
GLY A  16
 None
NDP  A1001 (-4.2A)
NDP  A1001 (-3.4A)
None
 0.85A 5a06B-2z95A:
7.1		 5a06B-2z95A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 4 ILE A  55
GLU A 701
GLY A 725
GLY A 724
 None
 0.86A 5a06B-3a0fA:
undetectable		 5a06B-3a0fA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ap1 PROTEIN-TYROSINE
SULFOTRANSFERASE 2

(Homo sapiens) 		PF13469
(Sulfotransfer_3) 		4 LYS A 164
LEU A 163
GLY A  75
GLY A  74
 None
 0.79A 5a06B-3ap1A:
undetectable		 5a06B-3ap1A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1h PUTATIVE
UNCHARACTERIZED
PROTEIN

(Neurospora
crassa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 150
CYH A 120
GLY A 155
GLY A 154
 None
 0.77A 5a06B-3e1hA:
undetectable		 5a06B-3e1hA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2n CYTOCHROME C
PEROXIDASE

(Pisum sativum;
Saccharomyces
cerevisiae) 		PF00141
(peroxidase) 		4 ILE A  26
LEU A  39
GLY A 105
GLY A 104
 None
 0.74A 5a06B-3e2nA:
undetectable		 5a06B-3e2nA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3c L0044

(Escherichia
coli) 		PF16518
(GrlR) 		4 ILE A  25
LEU A  24
GLY A  34
GLY A  33
 None
HHG  A 150 (-4.9A)
None
None
 0.77A 5a06B-3e3cA:
undetectable		 5a06B-3e3cA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 150
CYH A 120
GLY A 155
GLY A 154
 None
 0.79A 5a06B-3euoA:
undetectable		 5a06B-3euoA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvm AGMATINE DEIMINASE

(Helicobacter
pylori) 		PF04371
(PAD_porph) 		4 ILE A  88
GLU A 145
GLY A 142
GLY A 141
 None
 0.67A 5a06B-3hvmA:
undetectable		 5a06B-3hvmA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Colwellia
psychrerythraea) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ILE A  10
GLU A  35
GLY A  14
GLY A  17
 None
FAD  A 490 (-2.8A)
FAD  A 490 (-3.2A)
None
 0.83A 5a06B-3ic9A:
undetectable		 5a06B-3ic9A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krb ALDOSE REDUCTASE

(Giardia
intestinalis) 		PF00248
(Aldo_ket_red) 		4 ILE A 224
CYH A 227
LYS A 231
LEU A 230
 None
 0.76A 5a06B-3krbA:
undetectable		 5a06B-3krbA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 4 ILE X  98
LEU X 167
GLY X 145
GLY X 144
 None
 0.85A 5a06B-3kvnX:
3.1		 5a06B-3kvnX:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxq TRIOSEPHOSPHATE
ISOMERASE

(Bartonella
henselae) 		PF00121
(TIM) 		4 LYS A  88
LEU A  87
GLY A  66
GLY A  67
 None
 0.64A 5a06B-3kxqA:
2.5		 5a06B-3kxqA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqz HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DP ALPHA 1
CHAIN

(Homo sapiens) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		4 ILE A  63
LEU A  60
GLY A  58
GLY A  59
 None
 0.81A 5a06B-3lqzA:
undetectable		 5a06B-3lqzA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lun ULILYSIN

(Methanosarcina
acetivorans) 		PF05572
(Peptidase_M43) 		4 ILE A 205
CYH A 176
LEU A 179
GLY A 189
 None
 0.73A 5a06B-3lunA:
undetectable		 5a06B-3lunA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0l SERINE
HYDROXYMETHYLTRANSFE
RASE

(Campylobacter
jejuni) 		PF00464
(SHMT) 		4 ILE A 395
LYS A 400
LEU A 399
GLY A 334
 None
 0.82A 5a06B-3n0lA:
undetectable		 5a06B-3n0lA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5m ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		5 ILE A 227
LEU A 228
GLU A 219
GLY A 225
GLY A 226
 None
 1.18A 5a06B-3n5mA:
undetectable		 5a06B-3n5mA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8l GERANYLTRANSTRANSFER
ASE

(Enterococcus
faecalis) 		PF00348
(polyprenyl_synt) 		4 ILE A 199
LEU A 202
GLY A 188
GLY A 189
 None
 0.66A 5a06B-3p8lA:
undetectable		 5a06B-3p8lA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		4 ILE B 194
CYH B 197
GLY B 179
GLY B 180
 None
 0.67A 5a06B-3pz2B:
undetectable		 5a06B-3pz2B:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3riq TAILSPIKE PROTEIN

(Salmonella
virus 9NA) 		PF09251
(PhageP22-tail) 		4 ILE A 369
LEU A 368
GLY A 339
GLY A 340
 None
 0.87A 5a06B-3riqA:
undetectable		 5a06B-3riqA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t33 G PROTEIN COUPLED
RECEPTOR

(Arabidopsis
thaliana) 		PF05147
(LANC_like) 		4 ILE A 327
LEU A 383
GLY A 388
GLY A 389
 None
 0.76A 5a06B-3t33A:
undetectable		 5a06B-3t33A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc1 OCTAPRENYL
PYROPHOSPHATE
SYNTHASE

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		4 ILE A 167
LYS A 172
LEU A 171
GLY A 189
 None
 0.74A 5a06B-3tc1A:
undetectable		 5a06B-3tc1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT

(Thermus
aquaticus) 		PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		4 ILE B 309
GLU B 345
GLY B 312
GLY B 311
 None
 0.87A 5a06B-3ufxB:
undetectable		 5a06B-3ufxB:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w2w CRISPR SYSTEM CMR
SUBUNIT CMR3

(Pyrococcus
furiosus) 		PF09700
(Cas_Cmr3) 		4 ILE B 320
LEU B 227
GLY B 318
GLY B 319
 None
 0.80A 5a06B-3w2wB:
undetectable		 5a06B-3w2wB:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxy PUTATIVE
UNCHARACTERIZED
PROTEIN CSYB

(Aspergillus
oryzae) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 153
CYH A 123
GLY A 158
GLY A 157
 None
 0.81A 5a06B-3wxyA:
undetectable		 5a06B-3wxyA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asc KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF01344
(Kelch_1) 		4 ILE A 562
LEU A 550
GLY A 564
GLY A 563
 None
 0.82A 5a06B-4ascA:
2.3		 5a06B-4ascA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9c MAJOR STRAWBERRY
ALLERGEN FRA A 1-E

(Fragaria x
ananassa) 		PF00407
(Bet_v_1) 		4 ILE A  44
LYS A  71
GLY A  50
GLY A  49
 None
 0.76A 5a06B-4c9cA:
undetectable		 5a06B-4c9cA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cok PYRUVATE
DECARBOXYLASE

(Gluconacetobacter
diazotrophicus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 CYH A 529
LEU A 510
GLY A 508
GLY A 507
 None
 0.81A 5a06B-4cokA:
2.3		 5a06B-4cokA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di1 ENOYL-COA HYDRATASE
ECHA17

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		4 ILE A  87
LEU A  84
GLY A 139
GLY A 140
 None
 0.80A 5a06B-4di1A:
undetectable		 5a06B-4di1A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dve BIOTIN TRANSPORTER
BIOY

(Lactococcus
lactis) 		PF02632
(BioY) 		4 ILE A 103
LYS A 108
LEU A 107
GLY A  50
 None
BNG  A 203 (-2.2A)
None
None
 0.73A 5a06B-4dveA:
undetectable		 5a06B-4dveA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl0 AMINOTRANSFERASE
ALD1

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		4 ILE A 345
LEU A 342
GLY A 340
GLY A 341
 None
 0.87A 5a06B-4fl0A:
undetectable		 5a06B-4fl0A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 ILE A  69
LEU A  63
GLY A  67
GLY A  68
 None
 0.79A 5a06B-4fxsA:
undetectable		 5a06B-4fxsA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT

(Escherichia
coli) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 CYH A  84
LEU A  86
GLY A  88
GLY A  89
 None
 0.80A 5a06B-4g38A:
undetectable		 5a06B-4g38A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH) 		4 ILE A  69
LEU A  63
GLY A  67
GLY A  68
 None
 0.82A 5a06B-4ix2A:
undetectable		 5a06B-4ix2A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo0 CMLA

(Streptomyces
venezuelae) 		PF12706
(Lactamase_B_2) 		4 LEU A 341
GLU A 144
GLY A 343
GLY A 342
 None
 0.85A 5a06B-4jo0A:
undetectable		 5a06B-4jo0A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF13416
(SBP_bac_8) 		4 ILE A1067
GLU A1229
GLY A1062
GLY A1063
 None
 0.73A 5a06B-4kegA:
undetectable		 5a06B-4kegA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk3 UDP-GLUCURONIC ACID
DECARBOXYLASE 1

(Homo sapiens) 		PF16363
(GDP_Man_Dehyd) 		4 ILE A  93
LEU A 159
GLY A  98
GLY A 101
 None
NAD  A 501 (-4.4A)
NAD  A 501 (-3.1A)
None
 0.86A 5a06B-4lk3A:
5.2		 5a06B-4lk3A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9w ARA H 8 ALLERGEN

(Arachis
hypogaea) 		PF00407
(Bet_v_1) 		4 ILE A  42
LYS A  69
GLY A  48
GLY A  47
 None
 0.84A 5a06B-4m9wA:
undetectable		 5a06B-4m9wA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfv BETA-CATENIN-LIKE
PROTEIN 1

(Homo sapiens) 		PF08216
(CTNNBL) 		4 ILE A 286
CYH A 320
LEU A 280
GLY A 285
 None
 0.79A 5a06B-4mfvA:
undetectable		 5a06B-4mfvA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ml9 UNCHARACTERIZED
PROTEIN

(Sebaldella
termitidis) 		PF00977
(His_biosynth) 		4 ILE A 138
GLU A 119
GLY A 110
GLY A 111
 None
 0.74A 5a06B-4ml9A:
undetectable		 5a06B-4ml9A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nvt TRIOSEPHOSPHATE
ISOMERASE

(Brucella
melitensis) 		PF00121
(TIM) 		4 LYS A  88
LEU A  87
GLY A  66
GLY A  67
 None
 0.66A 5a06B-4nvtA:
undetectable		 5a06B-4nvtA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305

(Thermoplasma
acidophilum) 		no annotation 4 ILE A  22
LEU A  31
GLY A  20
GLY A  21
 None
 0.84A 5a06B-4rkzA:
undetectable		 5a06B-4rkzA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y90 TRIOSEPHOSPHATE
ISOMERASE

(Deinococcus
radiodurans) 		PF00121
(TIM) 		4 LYS A  85
LEU A  84
GLY A  63
GLY A  64
 None
 0.58A 5a06B-4y90A:
undetectable		 5a06B-4y90A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yrd CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP5F

(Staphylococcus
aureus) 		PF01370
(Epimerase) 		4 ILE A   5
LEU A  53
GLY A  10
GLY A  13
 None
 0.84A 5a06B-4yrdA:
8.0		 5a06B-4yrdA:
21.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a05 ALDOSE-ALDOSE
OXIDOREDUCTASE

(Caulobacter
vibrioides) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		6 ILE A 117
CYH A 120
LYS A 126
LEU A 127
GLY A 313
GLY A 314
 None
 0.23A 5a06B-5a05A:
33.4		 5a06B-5a05A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG

(Cupriavidus
necator;
Cupriavidus
necator) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
PF00374
(NiFeSe_Hases) 		4 ILE C  57
LEU A  30
GLY A  97
GLY A  29
 None
None
SF4  A 503 ( 4.3A)
None
 0.73A 5a06B-5aa5C:
undetectable		 5a06B-5aa5C:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olt -

(-) 		no annotation 4 ILE A 283
LEU A 286
GLY A 341
GLY A 340
 None
 0.68A 5a06B-5oltA:
undetectable		 5a06B-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uzh NAFOA.00085.B

(Naegleria
fowleri) 		PF16363
(GDP_Man_Dehyd) 		4 ILE A  38
LEU A 117
GLY A  43
GLY A  46
 None
NAP  A 402 (-4.3A)
NAP  A 402 (-3.4A)
None
 0.86A 5a06B-5uzhA:
6.5		 5a06B-5uzhA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1s RADICAL SAM

(Streptococcus
suis) 		PF04055
(Radical_SAM)
PF13394
(Fer4_14) 		4 ILE A  18
LEU A  30
GLY A  16
GLY A  17
 None
 0.86A 5a06B-5v1sA:
undetectable		 5a06B-5v1sA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT 3

(Homo sapiens) 		PF14987
(NADHdh_A3) 		4 ILE U  31
LEU U  28
GLY U  26
GLY U  27
 None
None
PLX  U 101 (-3.4A)
PLX  U 101 ( 4.7A)
 0.87A 5a06B-5xtcU:
undetectable		 5a06B-5xtcU:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica) 		no annotation 4 LEU A 139
GLU A 244
GLY A 239
GLY A 240
 None
 0.75A 5a06B-5yhpA:
3.7		 5a06B-5yhpA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2e DIHYDRODIPICOLINATE
REDUCTASE

(Paenisporosarcina
sp. TG-14) 		no annotation 4 ILE A   6
LEU A  75
GLY A  11
GLY A  14
 None
 0.85A 5a06B-5z2eA:
14.0		 5a06B-5z2eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8y THREONYLCARBAMOYL-AM
P SYNTHASE

(Pyrococcus
abyssi) 		no annotation 4 ILE A 177
LEU A 321
GLY A 197
GLY A 198
 None
 0.85A 5a06B-6f8yA:
undetectable		 5a06B-6f8yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fc5 MICROTUBULE-ASSOCIAT
ED PROTEIN

(Saccharomyces
cerevisiae) 		no annotation 4 ILE A   8
CYH A  10
LEU A  22
GLY A  37
 None
 0.74A 5a06B-6fc5A:
undetectable		 5a06B-6fc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6req PROTEIN
(METHYLMALONYL-COA
MUTASE)

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase) 		4 ILE B 294
LEU B 297
GLY B 354
GLY B 353
 None
 0.81A 5a06B-6reqB:
8.6		 5a06B-6reqB:
21.13