SIMILAR PATTERNS OF AMINO ACIDS FOR 5A06_B_SORB1341

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqc PROTEIN
(BETA-MANNANASE)

(Thermobifida
fusca) 		PF00150
(Cellulase) 		4 PHE A 214
ASP A 170
ILE A 195
TYR A 201
 None
 1.32A 5a06B-1bqcA:
1.2		 5a06B-1bqcA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus) 		PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		4 ARG A 170
ARG A 200
ILE A 202
TYR A 172
 None
 1.37A 5a06B-1dq3A:
0.0		 5a06B-1dq3A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqu ISOCITRATE LYASE

(Aspergillus
nidulans) 		PF00463
(ICL) 		4 PHE A  34
ARG A  32
ASP A 232
ILE A  39
 None
 1.38A 5a06B-1dquA:
1.4		 5a06B-1dquA:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1evj GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		6 LYS A 129
ARG A 157
ARG A 200
ASP A 213
ILE A 214
TYR A 217
 NAD  A 500 (-3.4A)
NAD  A 500 (-3.9A)
NAD  A 500 (-3.0A)
None
None
None
 0.46A 5a06B-1evjA:
48.5		 5a06B-1evjA:
49.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 PHE A 290
ARG A 334
ASP A 312
TYR A 287
 None
 1.35A 5a06B-1ezvA:
0.0		 5a06B-1ezvA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 LYS B 701
ARG B1012
ILE B1053
TYR B1013
 None
 1.29A 5a06B-1gl9B:
2.3		 5a06B-1gl9B:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gmx THIOSULFATE
SULFURTRANSFERASE
GLPE

(Escherichia
coli) 		PF00581
(Rhodanese) 		4 LYS A  15
ASP A  11
ILE A   7
TYR A  87
 None
None
None
EDO  A1114 ( 4.2A)
 1.39A 5a06B-1gmxA:
1.3		 5a06B-1gmxA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1

(Escherichia
coli) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ARG A 346
ARG A 278
ILE A  29
TYR A  33
 None
 1.25A 5a06B-1h17A:
undetectable		 5a06B-1h17A:
18.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h6d PRECURSOR FORM OF
GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		6 LYS A 181
ARG A 209
ARG A 252
ASP A 265
ILE A 266
TYR A 269
 GOL  A 600 ( 2.5A)
NDP  A 500 (-4.0A)
NDP  A 500 ( 2.8A)
GOL  A 600 (-2.9A)
None
GOL  A 600 ( 4.3A)
 0.54A 5a06B-1h6dA:
48.6		 5a06B-1h6dA:
44.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhm PYRUVATE
FORMATE-LYASE

(Escherichia
coli) 		PF02901
(PFL-like) 		4 ARG A1346
ARG A1278
ILE A1029
TYR A1033
 None
 1.21A 5a06B-1qhmA:
undetectable		 5a06B-1qhmA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfs HYPOTHETICAL PROTEIN

(Geobacillus
stearothermophilus) 		PF08924
(DUF1906) 		4 ARG A 195
PHE A 107
ARG A  69
TYR A 131
 None
 1.33A 5a06B-1sfsA:
undetectable		 5a06B-1sfsA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te5 CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF13230
(GATase_4) 		4 PHE A 184
ARG A 166
ASP A 163
ILE A 159
 None
 1.13A 5a06B-1te5A:
undetectable		 5a06B-1te5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE

(Pyrococcus
horikoshii) 		PF04587
(ADP_PFK_GK) 		4 ARG A 213
PHE A 283
ARG A 292
ILE A 295
 None
 1.34A 5a06B-1u2xA:
4.2		 5a06B-1u2xA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3

(Homo sapiens) 		PF01088
(Peptidase_C12) 		4 ARG A 215
ARG A 186
ASP A 184
ILE A 171
 None
 1.16A 5a06B-1uchA:
undetectable		 5a06B-1uchA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3

(Homo sapiens) 		PF01088
(Peptidase_C12) 		4 PHE A  56
ARG A 186
ASP A 184
ILE A 171
 None
 1.35A 5a06B-1uchA:
undetectable		 5a06B-1uchA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um2 ENDONUCLEASE PI-SCEI
21-MER FROM VACUOLAR
ATP SYNTHASE
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF05203
(Hom_end_hint)
PF05204
(Hom_end)
no annotation 		4 ARG C 741
ARG A 445
ASP A 446
ILE A 442
 None
 1.27A 5a06B-1um2C:
undetectable		 5a06B-1um2C:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		4 PHE C 572
ARG C 366
ILE C 365
TYR C 510
 None
 1.08A 5a06B-1wa5C:
undetectable		 5a06B-1wa5C:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhc NADH OXIDASE
/NITRITE REDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2) 		4 ARG A 249
ASP A 245
ILE A 244
TYR A 264
 None
 1.28A 5a06B-1xhcA:
undetectable		 5a06B-1xhcA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3n ALGQ1

(Sphingomonas
sp. A1) 		PF01547
(SBP_bac_1) 		4 ARG A 250
ASP A 244
ILE A 247
TYR A 238
 None
 0.98A 5a06B-1y3nA:
undetectable		 5a06B-1y3nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 HYPOTHETICAL PROTEIN
PH1363
SARCOSINE OXIDASE

(Pyrococcus
horikoshii;
Pyrococcus
horikoshii) 		PF07992
(Pyr_redox_2)
PF13510
(Fer2_4)
PF01266
(DAO) 		4 ARG A 490
PHE B 280
ILE B 264
TYR B 287
 None
 1.40A 5a06B-1y56A:
undetectable		 5a06B-1y56A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydw AX110P-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01408
(GFO_IDH_MocA) 		5 LYS A 102
PHE A 162
ARG A 174
ASP A 187
TYR A 191
 None
 1.13A 5a06B-1ydwA:
37.5		 5a06B-1ydwA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydw AX110P-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01408
(GFO_IDH_MocA) 		4 PHE A 243
ARG A 174
ASP A 187
TYR A 191
 None
 1.38A 5a06B-1ydwA:
37.5		 5a06B-1ydwA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yem CONSERVED
HYPOTHETICAL PROTEIN
PFU-838710-001

(Pyrococcus
furiosus) 		PF01928
(CYTH) 		4 ARG A  47
ASP A  33
ILE A  98
TYR A 159
 UNX  A 205 ( 3.8A)
None
None
UNX  A 202 ( 4.5A)
 1.40A 5a06B-1yemA:
undetectable		 5a06B-1yemA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yln HYPOTHETICAL PROTEIN
VCA0042

(Vibrio cholerae) 		PF07238
(PilZ)
PF12945
(YcgR_2) 		4 ARG A 211
ASP A 183
ILE A 206
TYR A 218
 None
 1.38A 5a06B-1ylnA:
undetectable		 5a06B-1ylnA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 LYS A 103
ASP A 260
ILE A 288
TYR A  98
 None
 1.22A 5a06B-2c4kA:
undetectable		 5a06B-2c4kA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlt MYOSIN BINDING
PROTEIN C, FAST-TYPE

(Mus musculus) 		PF07679
(I-set) 		4 LYS A  43
ARG A  71
ASP A  74
ILE A  67
 None
 1.21A 5a06B-2dltA:
undetectable		 5a06B-2dltA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epg HYPOTHETICAL PROTEIN
TTHA1785

(Thermus
thermophilus) 		PF01139
(RtcB) 		4 ARG A 350
ARG A 297
ASP A 325
ILE A 170
 None
 1.14A 5a06B-2epgA:
undetectable		 5a06B-2epgA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7c TOXIN A

(Clostridioides
difficile) 		PF01473
(CW_binding_1) 		4 LYS A  21
ASP A  69
ILE A  71
TYR A  43
 None
 1.23A 5a06B-2g7cA:
undetectable		 5a06B-2g7cA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glx 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Ensifer
adhaerens) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 LYS A  94
PHE A 232
ARG A 163
ASP A 176
ILE A 177
 NDP  A1500 ( 2.9A)
None
NDP  A1500 (-3.0A)
ACT  A1502 ( 3.9A)
None
 1.34A 5a06B-2glxA:
39.0		 5a06B-2glxA:
29.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja9 EXOSOME COMPLEX
EXONUCLEASE RRP40

(Saccharomyces
cerevisiae) 		PF15985
(KH_6) 		4 ARG A 110
ASP A 117
ILE A  76
TYR A  84
 None
 0.91A 5a06B-2ja9A:
undetectable		 5a06B-2ja9A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kiw INT PROTEIN

(Staphylococcus
haemolyticus) 		PF14659
(Phage_int_SAM_3) 		4 ARG A  98
ASP A 118
ILE A 119
TYR A 123
 None
 1.21A 5a06B-2kiwA:
undetectable		 5a06B-2kiwA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9u A-TYPE FLAVOPROTEIN

(Giardia
intestinalis) 		no annotation 4 ARG A 141
ASP A 164
ILE A 166
TYR A 225
 None
 1.20A 5a06B-2q9uA:
4.4		 5a06B-2q9uA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qru UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF07859
(Abhydrolase_3) 		4 ARG A 141
PHE A 186
ILE A  37
TYR A 174
 None
None
None
PO4  A 273 ( 4.6A)
 1.40A 5a06B-2qruA:
3.5		 5a06B-2qruA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN

(Escherichia
coli) 		PF03349
(Toluene_X) 		4 ARG A 282
ARG A 342
ILE A  23
TYR A 280
 None
 1.31A 5a06B-2r8aA:
undetectable		 5a06B-2r8aA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6e PROTELEMORASE

(Klebsiella
phage phiKO2) 		PF16684
(Telomere_res) 		4 PHE A 428
ARG A 377
ILE A 233
TYR A 238
 None
 1.36A 5a06B-2v6eA:
undetectable		 5a06B-2v6eA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynt GIM-1 PROTEIN

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 PHE B 218
ARG B 121
ASP B  84
ILE B  83
 None
ZN  B1298 ( 4.5A)
None
None
 1.35A 5a06B-2yntB:
undetectable		 5a06B-2yntB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywv PHOSPHORIBOSYLAMINOI
MIDAZOLE
SUCCINOCARBOXAMIDE
SYNTHETASE

(Geobacillus
kaustophilus) 		PF01259
(SAICAR_synt) 		4 ARG A 218
ARG A  95
ASP A 176
ILE A 175
 None
SO4  A 543 (-3.3A)
SO4  A 543 ( 4.6A)
None
 0.99A 5a06B-2ywvA:
undetectable		 5a06B-2ywvA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B

(Sulfolobus
shibatae) 		PF02518
(HATPase_c)
PF09239
(Topo-VIb_trans) 		4 ARG B 372
ASP B 386
ILE B 430
TYR B 422
 None
 1.33A 5a06B-2zbkB:
undetectable		 5a06B-2zbkB:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay0 UNCHARACTERIZED
PROTEIN MJ0883

(Methanocaldococcus
jannaschii) 		PF02475
(Met_10) 		4 ARG A 315
ARG A 261
ILE A 263
TYR A 290
 None
 1.33A 5a06B-3ay0A:
4.8		 5a06B-3ay0A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 LYS A 635
ARG A 892
PHE A 737
ASP A 735
 None
 1.14A 5a06B-3bgaA:
undetectable		 5a06B-3bgaA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq9 PREDICTED ROSSMANN
FOLD
NUCLEOTIDE-BINDING
DOMAIN-CONTAINING
PROTEIN

(Idiomarina
baltica) 		PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478) 		4 ARG A  35
ARG A 402
ASP A 398
TYR A  55
 None
 1.37A 5a06B-3bq9A:
4.3		 5a06B-3bq9A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d19 CONSERVED
METALLOPROTEIN

(Bacillus cereus) 		PF11155
(DUF2935) 		4 PHE A 158
ARG A 262
ILE A 266
TYR A 270
 None
 1.33A 5a06B-3d19A:
undetectable		 5a06B-3d19A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 LYS A 611
ARG A 868
PHE A 713
ASP A 711
 None
 1.15A 5a06B-3decA:
undetectable		 5a06B-3decA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f41 PHYTASE

(Mitsuokella
multacida) 		PF14566
(PTPlike_phytase) 		4 ARG A 448
ASP A 158
ILE A 159
TYR A 603
 None
 0.96A 5a06B-3f41A:
undetectable		 5a06B-3f41A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)

(Paracoccus
denitrificans) 		PF05853
(BKACE) 		4 ARG A  91
ARG A 230
ASP A 235
ILE A 211
 CL  A 285 (-4.0A)
MG  A 282 ( 3.8A)
None
None
 0.87A 5a06B-3fa5A:
undetectable		 5a06B-3fa5A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdi PERIOD CIRCADIAN
PROTEIN HOMOLOG 2

(Mus musculus) 		PF08447
(PAS_3) 		4 ARG A 397
ASP A 372
ILE A 396
TYR A 393
 None
 1.39A 5a06B-3gdiA:
undetectable		 5a06B-3gdiA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kea K1L

(Vaccinia virus) 		PF12796
(Ank_2) 		4 LYS A 247
ASP A 264
ILE A 267
TYR A 277
 None
 1.35A 5a06B-3keaA:
undetectable		 5a06B-3keaA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx9 PROTEIN SCV3V2(G19S)

(Chlamydomonas
reinhardtii) 		PF00961
(LAGLIDADG_1) 		4 ARG A  68
ARG A  40
ILE A  24
TYR A  44
 None
 1.34A 5a06B-3mx9A:
undetectable		 5a06B-3mx9A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0g ISOPRENE SYNTHASE

(Populus tremula
x Populus alba) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ARG A 133
ARG A  94
ASP A 126
ILE A  97
 None
 1.17A 5a06B-3n0gA:
undetectable		 5a06B-3n0gA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nua PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Clostridium
perfringens) 		PF01259
(SAICAR_synt) 		4 ARG A 217
ARG A  95
ASP A 176
ILE A 175
 None
AMP  A 242 (-3.1A)
AMP  A 242 (-3.4A)
None
 1.06A 5a06B-3nuaA:
undetectable		 5a06B-3nuaA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1
ABL INTERACTOR 2

(Homo sapiens;
Homo sapiens) 		PF09735
(Nckap1)
PF07815
(Abi_HHR) 		4 LYS F 116
ARG B 763
ASP B 760
ILE B 761
 None
 1.01A 5a06B-3p8cF:
undetectable		 5a06B-3p8cF:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c WISKOTT-ALDRICH
SYNDROME PROTEIN
FAMILY MEMBER 1
PROBABLE PROTEIN
BRICK1

(Homo sapiens;
Homo sapiens) 		PF02205
(WH2)
no annotation 		4 ARG E  44
ASP E  40
ILE D  51
TYR D  47
 None
 1.35A 5a06B-3p8cE:
undetectable		 5a06B-3p8cE:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Salmonella
enterica) 		PF00290
(Trp_syntA) 		4 ARG A 179
PHE A  22
ASP A  60
ILE A  64
 F9F  A   1 ( 4.9A)
F9F  A   1 (-3.7A)
F9F  A   1 ( 4.5A)
None
 1.36A 5a06B-3pr2A:
undetectable		 5a06B-3pr2A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttb EIGHT-HEME NITRITE
REDUCTASE

(Thioalkalivibrio
paradoxus) 		PF02335
(Cytochrom_C552) 		4 ARG A 117
PHE A 127
ILE A 159
TYR A 139
 None
 1.17A 5a06B-3ttbA:
undetectable		 5a06B-3ttbA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2y SPHINGOSINE
1-PHOSPHATE RECEPTOR
1, LYSOZYME CHIMERA
(E.C.3.2.1.17)

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 ARG A1145
PHE A1004
ARG A1008
ILE A1029
 None
 1.29A 5a06B-3v2yA:
undetectable		 5a06B-3v2yA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b5m PUTATIVE
EXODEOXYRIBONUCLEASE

(Neisseria
meningitidis) 		PF03372
(Exo_endo_phos) 		4 ARG A 219
ARG A 176
ILE A 179
TYR A 222
 None
 1.20A 5a06B-4b5mA:
undetectable		 5a06B-4b5mA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8j IMPORTIN SUBUNIT
ALPHA-1A

(Oryza sativa) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		4 ARG A  29
PHE A 383
ASP A 425
ILE A 428
 None
 1.31A 5a06B-4b8jA:
undetectable		 5a06B-4b8jA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzx BIFUNCTIONAL ENZYME
CYSN/CYSC

(Mycobacterium
tuberculosis) 		PF01583
(APS_kinase) 		4 ARG A 530
ARG A 592
ASP A 550
TYR A 583
 CIT  A1623 (-3.9A)
None
EDO  A1615 ( 4.0A)
EDO  A1615 ( 4.9A)
 1.29A 5a06B-4bzxA:
undetectable		 5a06B-4bzxA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 PHE A 113
ARG A 101
ASP A 540
ILE A 115
 None
 1.30A 5a06B-4c30A:
undetectable		 5a06B-4c30A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1t METALLO-B-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 PHE A 218
ARG A 121
ASP A  84
ILE A  83
 None
ZN  A1293 ( 4.7A)
None
None
 1.37A 5a06B-4d1tA:
undetectable		 5a06B-4d1tA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4din CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-BETA REGULATORY
SUBUNIT

(Homo sapiens) 		PF00027
(cNMP_binding)
PF02197
(RIIa) 		4 PHE B 148
ARG B 144
ILE B 147
TYR B 229
 None
 1.09A 5a06B-4dinB:
undetectable		 5a06B-4dinB:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Streptococcus
pneumoniae) 		PF01259
(SAICAR_synt) 		4 ARG A 215
ARG A  93
ASP A 174
ILE A 173
 None
AIR  A 301 (-2.9A)
AIR  A 301 (-2.9A)
None
 1.07A 5a06B-4fe2A:
undetectable		 5a06B-4fe2A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fk9 CELLULOSE-BINDING
FAMILY II

(Streptomyces
sp. SirexAA-E) 		PF00150
(Cellulase) 		4 PHE A 262
ASP A 218
ILE A 243
TYR A 249
 None
 1.34A 5a06B-4fk9A:
undetectable		 5a06B-4fk9A:
24.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h3v OXIDOREDUCTASE
DOMAIN PROTEIN

(Kribbella
flavida) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LYS A 103
ARG A 178
ASP A 191
ILE A 192
 None
 1.04A 5a06B-4h3vA:
36.8		 5a06B-4h3vA:
30.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5y CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
1, T4-LYSOZYME
CHIMERIC CONSTRUCT

(Homo sapiens;
Escherichia
virus T4) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme) 		4 ARG A1145
PHE A1004
ARG A1008
ILE A1029
 None
 1.24A 5a06B-4k5yA:
undetectable		 5a06B-4k5yA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4koa 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LYS A  94
PHE A 232
ASP A 176
ILE A 177
 NDP  A 500 (-3.2A)
None
NDP  A 500 (-2.9A)
None
 1.24A 5a06B-4koaA:
37.3		 5a06B-4koaA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myc IRON-SULFUR CLUSTERS
TRANSPORTER ATM1,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 ARG A 492
ASP A 499
ILE A 500
TYR A 503
 None
 1.22A 5a06B-4mycA:
undetectable		 5a06B-4mycA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME

(Saccharomyces
cerevisiae;
Escherichia
virus T4) 		PF00959
(Phage_lysozyme)
PF11951
(Fungal_trans_2) 		4 ARG A1145
PHE A1004
ARG A1008
ILE A1029
 None
 1.24A 5a06B-4n9nA:
undetectable		 5a06B-4n9nA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfd PAIRED
IMMUNOGLOBULIN-LIKE
TYPE 2 RECEPTOR BETA

(Homo sapiens) 		PF07686
(V-set) 		4 ARG A  86
ASP A  89
ILE A  82
TYR A  93
 None
 1.24A 5a06B-4nfdA:
undetectable		 5a06B-4nfdA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio
cholerae;
Vibrio
cholerae;
Vibrio cholerae) 		PF04205
(FMN_bind)
PF02508
(Rnf-Nqr)
PF02508
(Rnf-Nqr) 		4 ARG C  34
PHE E  80
ASP D  87
ILE D  84
 None
 0.84A 5a06B-4p6vC:
undetectable		 5a06B-4p6vC:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uou FUCOSE-SPECIFIC
LECTIN FLEA

(Aspergillus
fumigatus) 		PF07938
(Fungal_lectin) 		4 PHE A 180
ARG A 190
ILE A 178
TYR A 128
 None
 1.28A 5a06B-4uouA:
2.1		 5a06B-4uouA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN

(Agrobacterium
tumefaciens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 PHE A 415
ARG A 495
ILE A 444
TYR A 451
 None
 1.35A 5a06B-4uphA:
undetectable		 5a06B-4uphA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 4 LYS A  57
ASP A 161
ILE A 160
TYR A 165
 None
 1.19A 5a06B-4wseA:
undetectable		 5a06B-4wseA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I,
MODIFICATION SUBUNIT

(Escherichia
coli) 		PF01555
(N6_N4_Mtase) 		4 PHE A 204
ASP A 223
ILE A 245
TYR A 247
 None
 0.87A 5a06B-4zcfA:
undetectable		 5a06B-4zcfA:
20.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a05 ALDOSE-ALDOSE
OXIDOREDUCTASE

(Caulobacter
vibrioides) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		7 LYS A 104
ARG A 132
PHE A 163
ARG A 172
ASP A 185
ILE A 186
TYR A 189
 BGC  A1343 (-2.6A)
NDP  A1340 (-3.7A)
GLC  A1341 ( 3.6A)
NDP  A1340 (-2.8A)
BGC  A1343 ( 3.1A)
None
BGC  A1343 (-4.2A)
 0.11A 5a06B-5a05A:
33.4		 5a06B-5a05A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		4 PHE A 306
ASP A 541
ILE A 542
TYR A 518
 None
 1.35A 5a06B-5a2rA:
undetectable		 5a06B-5a2rA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus) 		PF01398
(JAB) 		4 PHE H 194
ARG H 313
ASP H 315
ILE H 319
 None
 1.33A 5a06B-5a5tH:
undetectable		 5a06B-5a5tH:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA

(Methanothermobacter
marburgensis;
Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ARG B 383
ARG A 463
ASP B 228
TYR B 190
 None
 1.28A 5a06B-5a8rB:
undetectable		 5a06B-5a8rB:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aea NEURAL CELL ADHESION
MOLECULE 1

(Homo sapiens) 		PF07679
(I-set) 		4 ARG A  49
ASP A  71
ILE A  64
TYR A  75
 None
 1.29A 5a06B-5aeaA:
undetectable		 5a06B-5aeaA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0n FAB CA33 HEAVY CHAIN

(Oryctolagus
cuniculus) 		no annotation 4 ARG H  65
ASP H  86
ILE H  79
TYR H  90
 None
 1.30A 5a06B-5c0nH:
undetectable		 5a06B-5c0nH:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cde PROLINE DIPEPTIDASE

(Xanthomonas
campestris) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 ARG A 328
PHE A 221
ASP A 262
ILE A 337
 SO4  A 401 (-3.9A)
None
ZN  A 402 ( 2.3A)
None
 0.96A 5a06B-5cdeA:
undetectable		 5a06B-5cdeA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl5 MEMBRANE PROTEIN

(Acinetobacter
baumannii) 		PF03573
(OprD) 		4 ARG A 203
ASP A 310
ILE A 312
TYR A 289
 None
 1.33A 5a06B-5dl5A:
undetectable		 5a06B-5dl5A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9g ISOCITRATE LYASE

(Magnaporthe
oryzae) 		PF00463
(ICL) 		4 PHE A  43
ARG A  41
ASP A 241
ILE A  48
 None
 1.38A 5a06B-5e9gA:
undetectable		 5a06B-5e9gA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffa COPM

(Synechocystis
sp. PCC 6803) 		PF03713
(DUF305) 		4 ARG A 104
ARG A 165
ILE A  50
TYR A  98
 None
 1.36A 5a06B-5ffaA:
undetectable		 5a06B-5ffaA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gx8 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Streptobacillus
moniliformis) 		PF13416
(SBP_bac_8) 		4 ARG A 264
ASP A 258
ILE A 261
TYR A 252
 SO4  A 605 (-2.8A)
None
None
None
 0.93A 5a06B-5gx8A:
undetectable		 5a06B-5gx8A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyd MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12

(Saccharomyces
cerevisiae) 		no annotation 4 LYS A 254
ASP A 250
ILE A 247
TYR A  27
 None
 1.34A 5a06B-5gydA:
undetectable		 5a06B-5gydA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h71 ALGQ2

(Sphingomonas
sp.) 		PF01547
(SBP_bac_1) 		4 ARG A 250
ASP A 244
ILE A 247
TYR A 238
 None
 1.00A 5a06B-5h71A:
undetectable		 5a06B-5h71A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqb ALPHA-GLUCOSIDASE

(Pseudoalteromonas
sp. K8) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 ARG A 464
ARG A 594
ASP A 572
TYR A 543
 None
 1.10A 5a06B-5hqbA:
undetectable		 5a06B-5hqbA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htk 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 2

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		4 ARG A 136
PHE A  90
ARG A  78
ILE A 101
 None
None
FLC  A 601 (-3.9A)
None
 1.40A 5a06B-5htkA:
undetectable		 5a06B-5htkA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv8 LPS BIOSYNTHESIS
PROTEIN

(Klebsiella
pneumoniae) 		PF04453
(OstA_C) 		4 ARG A 381
PHE A 342
ARG A 266
ASP A 294
 None
 1.12A 5a06B-5iv8A:
undetectable		 5a06B-5iv8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv9 LPS-ASSEMBLY PROTEIN
LPTD

(Klebsiella
pneumoniae) 		PF03968
(OstA)
PF04453
(OstA_C) 		4 ARG A 358
PHE A 319
ARG A 243
ASP A 271
 None
 1.29A 5a06B-5iv9A:
undetectable		 5a06B-5iv9A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 ARG A1727
PHE A1284
ASP A1286
ILE A1272
 None
 1.41A 5a06B-5m59A:
undetectable		 5a06B-5m59A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 ARG A  28
ARG A 230
ASP A 234
ILE A 184
 FUC  A 505 ( 4.3A)
None
None
None
 1.13A 5a06B-5m8tA:
undetectable		 5a06B-5m8tA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT

(Methanotorris
formicicus;
Methanotorris
formicicus) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ARG B 384
ARG A 463
ASP B 228
TYR B 190
 None
 1.26A 5a06B-5n28B:
undetectable		 5a06B-5n28B:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj2 MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1

(Gallus gallus) 		PF13927
(Ig_3) 		4 ARG A 299
ASP A 302
ILE A 295
TYR A 306
 None
 1.25A 5a06B-5oj2A:
undetectable		 5a06B-5oj2A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue7 PHOSPHOMANNOMUTASE

(Candida
albicans) 		PF03332
(PMM) 		4 PHE A 123
ARG A 119
ILE A 136
TYR A 148
 None
 1.17A 5a06B-5ue7A:
undetectable		 5a06B-5ue7A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4s TRANSPORTER, CATION
CHANNEL FAMILY /
CYCLIC
NUCLEOTIDE-BINDING
DOMAIN MULTI-DOMAIN
PROTEIN

(Leptospira
licerasiae) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans) 		4 ARG A  30
ASP A  49
ILE A  48
TYR A  45
 None
 1.32A 5a06B-5v4sA:
undetectable		 5a06B-5v4sA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byi BETA-MANNOSIDASE

(Xanthomonas
citri) 		no annotation 4 ARG A 299
ARG A 341
ASP A 465
ILE A 244
 None
 1.37A 5a06B-6byiA:
undetectable		 5a06B-6byiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6egx STRUCTURAL PROTEIN
VP1
STRUCTURAL PROTEIN
VP2

(Sacbrood virus;
Sacbrood virus) 		no annotation
no annotation 		4 ARG A 184
PHE A 178
ARG A  95
ILE B 142
 None
 1.38A 5a06B-6egxA:
undetectable		 5a06B-6egxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ffh METABOTROPIC
GLUTAMATE RECEPTOR
5,ENDOLYSIN

(Homo sapiens;
Escherichia
virus T4) 		no annotation 4 ARG A1145
PHE A1004
ARG A1008
ILE A1029
 None
 1.24A 5a06B-6ffhA:
undetectable		 5a06B-6ffhA:
undetectable