SIMILAR PATTERNS OF AMINO ACIDS FOR 5A06_A_SORA1344

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		4 GLU A 281
LYS A 720
ASP A 279
HIS A 713
 None
 1.25A 5a06A-1d8cA:
1.5		 5a06A-1d8cA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09083
(DUF1923) 		4 GLU A 329
LYS A 332
ASP A 326
GLU A 357
 None
 1.19A 5a06A-1gjuA:
1.3		 5a06A-1gjuA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kut PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Thermotoga
maritima) 		PF01259
(SAICAR_synt) 		4 GLU A 186
LYS A   8
ASP A 185
GLU A 172
 None
 1.42A 5a06A-1kutA:
undetectable		 5a06A-1kutA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nl3 PREPROTEIN
TRANSLOCASE SECA 1
SUBUNIT

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 GLU A 412
LYS A 415
ASP A 588
GLU A 556
 None
 1.49A 5a06A-1nl3A:
0.0		 5a06A-1nl3A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdt TETRAHYDRODIPICOLINA
TE-N-SUCCINYLTRANSFE
RASE

(Mycobacterium
bovis) 		PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2) 		4 GLU A 218
LYS A 255
ASP A 216
GLU A 221
 None
 1.06A 5a06A-1tdtA:
0.0		 5a06A-1tdtA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE

(Thermotoga
maritima) 		PF01207
(Dus) 		4 GLU A 266
LYS A 258
ASP A  17
GLU A  35
 None
 1.02A 5a06A-1vhnA:
2.0		 5a06A-1vhnA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7d UVRABC SYSTEM
PROTEIN B

(Bacillus
subtilis) 		PF00271
(Helicase_C)
PF02151
(UVR)
PF04851
(ResIII)
PF12344
(UvrB) 		4 GLU A 118
LYS A 121
ASP A 208
HIS A 210
 None
 1.37A 5a06A-2d7dA:
0.7		 5a06A-2d7dA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqs PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Escherichia
coli) 		PF01259
(SAICAR_synt) 		4 GLU A 192
LYS A  13
ASP A 191
GLU A 179
 None
ADP  A 238 (-2.6A)
MG  A 239 (-3.9A)
ADP  A 238 ( 3.7A)
 1.30A 5a06A-2gqsA:
undetectable		 5a06A-2gqsA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn8 RETICULON-4-INTERACT
ING PROTEIN 1

(Homo sapiens) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 GLU A 165
LYS A 151
HIS A  69
GLU A  73
 None
 1.30A 5a06A-2vn8A:
7.7		 5a06A-2vn8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywv PHOSPHORIBOSYLAMINOI
MIDAZOLE
SUCCINOCARBOXAMIDE
SYNTHETASE

(Geobacillus
kaustophilus) 		PF01259
(SAICAR_synt) 		4 GLU A 194
LYS A  14
ASP A 193
GLU A 180
 None
ADP  A 600 (-2.7A)
ADP  A 600 ( 3.5A)
ADP  A 600 (-3.3A)
 1.35A 5a06A-2ywvA:
undetectable		 5a06A-2ywvA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z02 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Methanocaldococcus
jannaschii) 		PF01259
(SAICAR_synt) 		4 GLU A 199
LYS A  20
ASP A 198
GLU A 185
 None
ATP  A1527 (-2.7A)
ATP  A1527 (-4.3A)
ATP  A1527 (-3.4A)
 1.38A 5a06A-2z02A:
undetectable		 5a06A-2z02A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1j ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF05362
(Lon_C)
PF13654
(AAA_32) 		4 GLU A 401
LYS A 397
ASP A 404
GLU A 403
 None
 1.20A 5a06A-3k1jA:
undetectable		 5a06A-3k1jA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nua PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Clostridium
perfringens) 		PF01259
(SAICAR_synt) 		4 GLU A 193
LYS A  14
ASP A 192
GLU A 180
 None
ADP  A 241 (-2.7A)
ADP  A 241 (-4.1A)
ADP  A 241 (-3.3A)
 1.25A 5a06A-3nuaA:
undetectable		 5a06A-3nuaA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 GLU A 185
LYS A 188
ASP A 198
GLU A 202
 None
 1.47A 5a06A-4c30A:
undetectable		 5a06A-4c30A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Streptococcus
pneumoniae) 		PF01259
(SAICAR_synt) 		4 GLU A 192
LYS A  12
ASP A 191
GLU A 178
 None
ADP  A 302 (-2.8A)
ADP  A 302 ( 3.9A)
ADP  A 302 (-3.5A)
 1.42A 5a06A-4fe2A:
undetectable		 5a06A-4fe2A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594

(Pyrococcus
horikoshii) 		PF00326
(Peptidase_S9)
PF07676
(PD40) 		4 LYS B 237
ASP B 244
HIS B 243
GLU B 263
 MG  B 701 ( 4.4A)
MG  B 701 (-3.0A)
None
MG  B 701 (-2.6A)
 1.42A 5a06A-4hxeB:
3.6		 5a06A-4hxeB:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jeu SYNTAXIN-BINDING
PROTEIN 1

(Rattus
norvegicus) 		PF00995
(Sec1) 		4 GLU A 487
LYS A 465
ASP A 488
GLU A 491
 None
 1.42A 5a06A-4jeuA:
3.9		 5a06A-4jeuA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Pyrococcus
horikoshii) 		PF01259
(SAICAR_synt) 		4 GLU A 191
LYS A  13
ASP A 190
GLU A 177
 None
 1.31A 5a06A-4o7zA:
undetectable		 5a06A-4o7zA:
21.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a05 ALDOSE-ALDOSE
OXIDOREDUCTASE

(Caulobacter
vibrioides) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LYS A 290
ASP A 298
HIS A 299
GLU A 302
 None
 0.28A 5a06A-5a05A:
57.4		 5a06A-5a05A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE

(Enterobacter
cloacae) 		PF01977
(UbiD) 		4 GLU A 160
LYS A 196
ASP A 158
HIS A 189
 None
 1.23A 5a06A-5ny5A:
undetectable		 5a06A-5ny5A:
21.51