SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZZC_E_ACTE406

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)

(Homo sapiens) 		PF00079
(Serpin) 		4 ILE A 103
ARG A  47
TYR A  43
GLU A  51
 None
 1.09A 4zzcE-1by7A:
0.0		 4zzcE-1by7A:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)

(Hepacivirus C) 		PF00998
(RdRP_3) 		4 ILE A 447
ILE A 462
ARG A 465
TYR A 452
 None
 1.21A 4zzcE-1csjA:
0.2		 4zzcE-1csjA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1de6 L-RHAMNOSE ISOMERASE

(Escherichia
coli) 		PF06134
(RhaA) 		4 ILE A 340
ILE A 343
TYR A  73
GLU A 419
 None
 1.24A 4zzcE-1de6A:
0.0		 4zzcE-1de6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jji CARBOXYLESTERASE

(Archaeoglobus
fulgidus) 		PF07859
(Abhydrolase_3) 		4 ILE A   6
ARG A 281
TYR A 254
GLU A 253
 None
 1.25A 4zzcE-1jjiA:
0.0		 4zzcE-1jjiA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 ILE B 228
ARG B 280
TYR B 290
GLU B 282
 None
 1.12A 4zzcE-1m2vB:
4.5		 4zzcE-1m2vB:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 ILE A 397
ARG A 393
TYR A 436
GLU A 404
 None
 1.27A 4zzcE-1mewA:
undetectable		 4zzcE-1mewA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 ILE A 400
ARG A 509
TYR A 404
GLU A 381
 None
 1.26A 4zzcE-1nneA:
2.8		 4zzcE-1nneA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK

(Escherichia
coli) 		PF02615
(Ldh_2) 		4 ILE A  98
ILE A 266
TYR A 132
GLU A 267
 None
 1.27A 4zzcE-1nxuA:
undetectable		 4zzcE-1nxuA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0s NAD-DEPENDENT MALIC
ENZYME

(Ascaris suum) 		PF00390
(malic)
PF03949
(Malic_M) 		4 ILE A 335
ILE A 296
ARG A 376
GLU A 337
 None
 1.19A 4zzcE-1o0sA:
2.0		 4zzcE-1o0sA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus) 		PF00005
(ABC_tran) 		4 ILE K   4
ILE K  26
ARG K 210
GLU K  32
 None
None
IOD  K1917 (-4.5A)
None
 1.23A 4zzcE-1oxxK:
undetectable		 4zzcE-1oxxK:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd1 PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 ILE A 228
ARG A 280
TYR A 290
GLU A 282
 None
 1.14A 4zzcE-1pd1A:
4.3		 4zzcE-1pd1A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxp MU-LIKE CALPAIN

(Bos taurus;
Rattus
norvegicus) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		4 ILE A 689
ILE A 879
ARG A  12
GLU A 885
 None
 0.95A 4zzcE-1qxpA:
undetectable		 4zzcE-1qxpA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ab5 MRNA MATURASE

(Saccharomyces
cerevisiae) 		PF00961
(LAGLIDADG_1) 		4 ILE A 264
ILE A 306
TYR A 267
GLU A 410
 None
 1.28A 4zzcE-2ab5A:
undetectable		 4zzcE-2ab5A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1c CARBOXYPEPTIDASE B

(Helicoverpa zea) 		PF00246
(Peptidase_M14) 		4 ILE A 250
ILE A 164
ARG A 127
TYR A 248
 None
 1.24A 4zzcE-2c1cA:
undetectable		 4zzcE-2c1cA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox) 		PF00491
(Arginase) 		4 ILE A  33
ILE A   4
ARG A  90
GLU A  44
 None
 1.28A 4zzcE-2cevA:
undetectable		 4zzcE-2cevA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejx STK_08120

(Sulfurisphaera
tokodaii) 		PF11485
(DUF3211) 		4 ILE A  82
ILE A  96
ARG A  86
GLU A  69
 None
 1.25A 4zzcE-2ejxA:
undetectable		 4zzcE-2ejxA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ery RAS-RELATED PROTEIN
R-RAS2

(Homo sapiens) 		PF00071
(Ras) 		4 ILE A 175
ARG A  60
TYR A  15
GLU A  13
 None
 1.21A 4zzcE-2eryA:
undetectable		 4zzcE-2eryA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B

(Escherichia
coli) 		PF03372
(Exo_endo_phos) 		4 ILE A 125
ILE A  59
TYR A  85
GLU A  68
 None
 0.98A 4zzcE-2f1nA:
undetectable		 4zzcE-2f1nA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4n HYPOTHETICAL PROTEIN
MJ1651

(Methanocaldococcus
jannaschii) 		PF01887
(SAM_adeno_trans) 		5 ILE A 151
ILE A 125
ARG A 123
TYR A 103
GLU A  97
 None
 1.13A 4zzcE-2f4nA:
undetectable		 4zzcE-2f4nA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fm8 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAK

(Salmonella
enterica) 		PF03519
(Invas_SpaK) 		4 ILE A   6
ILE A  27
ARG A  11
GLU A   8
 None
 1.28A 4zzcE-2fm8A:
undetectable		 4zzcE-2fm8A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A 162
ILE A 167
ARG A 232
GLU A 282
 None
 1.14A 4zzcE-2fqdA:
undetectable		 4zzcE-2fqdA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 ILE A 112
ILE A 106
TYR A 165
GLU A 318
 None
 1.05A 4zzcE-2hakA:
undetectable		 4zzcE-2hakA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		4 ILE A  69
ILE A  61
TYR A  37
GLU A  58
 None
SAH  A 328 (-4.3A)
None
None
 1.15A 4zzcE-2i9kA:
undetectable		 4zzcE-2i9kA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o49 DNA-BINDING PROTEIN
SATB1

(Homo sapiens) 		PF02376
(CUT) 		4 ILE A 443
ARG A 385
TYR A 444
GLU A 382
 None
 1.25A 4zzcE-2o49A:
undetectable		 4zzcE-2o49A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oej 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE

(Geobacillus
kaustophilus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ILE A  77
ILE A  53
ARG A  17
GLU A  21
 None
 1.27A 4zzcE-2oejA:
undetectable		 4zzcE-2oejA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4i UNCHARACTERIZED
PROTEIN

(Cytophaga
hutchinsonii) 		PF14534
(DUF4440) 		4 ILE A  83
ARG A 102
TYR A  68
GLU A  11
 None
None
CIT  A 123 (-4.9A)
None
 1.15A 4zzcE-2r4iA:
undetectable		 4zzcE-2r4iA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr2 DIHYDROPYRIMIDINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 ILE A 385
ILE A  99
TYR A 245
GLU A 271
 None
 1.16A 4zzcE-2vr2A:
undetectable		 4zzcE-2vr2A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w20 SIALIDASE A

(Streptococcus
pneumoniae) 		PF13088
(BNR_2) 		4 ILE A 463
ILE A 530
TYR A 465
GLU A 450
 None
None
MES  A1791 (-3.7A)
MES  A1791 ( 3.9A)
 1.28A 4zzcE-2w20A:
undetectable		 4zzcE-2w20A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd9 ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL

(Homo sapiens) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ILE A 127
ILE A 132
TYR A 235
GLU A 214
 None
 1.20A 4zzcE-2wd9A:
undetectable		 4zzcE-2wd9A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA

(Homo sapiens) 		PF01504
(PIP5K) 		4 ILE A 245
ARG A 349
TYR A 353
GLU A 351
 None
 1.11A 4zzcE-2ybxA:
undetectable		 4zzcE-2ybxA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a27 UNCHARACTERIZED
PROTEIN MJ1557

(Methanocaldococcus
jannaschii) 		PF02475
(Met_10) 		4 ILE A 168
ILE A  93
ARG A  89
GLU A  86
 None
 1.18A 4zzcE-3a27A:
undetectable		 4zzcE-3a27A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cax UNCHARACTERIZED
PROTEIN PF0695

(Pyrococcus
furiosus) 		PF01814
(Hemerythrin)
PF13596
(PAS_10) 		4 ILE A 411
ILE A 369
TYR A 438
GLU A 453
 None
 1.03A 4zzcE-3caxA:
4.4		 4zzcE-3caxA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvw RE11660P

(Drosophila
melanogaster) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 ILE A  45
ILE A  96
ARG A  95
GLU A  91
 None
 1.16A 4zzcE-3cvwA:
undetectable		 4zzcE-3cvwA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ILE A 238
ILE A 240
ARG A 182
GLU A 234
 None
 1.10A 4zzcE-3dy5A:
undetectable		 4zzcE-3dy5A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE

(Plasmodium
vivax) 		PF01182
(Glucosamine_iso) 		4 ILE A 175
ILE A 185
TYR A 213
GLU A 210
 None
 1.11A 4zzcE-3e15A:
undetectable		 4zzcE-3e15A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f08 UNCHARACTERIZED
PROTEIN Q6HG14

(Bacillus
thuringiensis) 		PF10604
(Polyketide_cyc2) 		4 ILE A 124
ILE A  34
ARG A  46
GLU A  58
 None
 1.29A 4zzcE-3f08A:
undetectable		 4zzcE-3f08A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3k UNCHARACTERIZED
PROTEIN YKR043C

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		4 ILE A 130
ILE A 144
TYR A 102
GLU A  99
 None
 1.09A 4zzcE-3f3kA:
undetectable		 4zzcE-3f3kA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0t PUTATIVE
AMINOTRANSFERASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		4 ILE A 185
ILE A 218
TYR A 187
GLU A 219
 None
 1.05A 4zzcE-3g0tA:
undetectable		 4zzcE-3g0tA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 ILE A  38
ILE A  28
TYR A  10
GLU A  29
 None
 1.24A 4zzcE-3hkoA:
undetectable		 4zzcE-3hkoA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsi PHOSPHATIDYLSERINE
SYNTHASE

(Haemophilus
influenzae) 		PF13091
(PLDc_2) 		4 ILE A  26
ILE A 372
ARG A 171
GLU A 408
 None
 1.00A 4zzcE-3hsiA:
undetectable		 4zzcE-3hsiA:
20.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3igq GLR4197 PROTEIN

(Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		5 ILE A  73
ILE A  76
ARG A  85
TYR A 102
GLU A 104
 NA  A 801 ( 4.4A)
ACY  A 701 (-4.5A)
ACY  A 701 ( 3.2A)
ACY  A 701 ( 4.8A)
ACY  A 701 ( 4.8A)
 0.48A 4zzcE-3igqA:
24.6		 4zzcE-3igqA:
68.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io1 AMINOBENZOYL-GLUTAMA
TE UTILIZATION
PROTEIN

(Klebsiella
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ILE A 395
ILE A 207
TYR A 393
GLU A 375
 None
 1.14A 4zzcE-3io1A:
undetectable		 4zzcE-3io1A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j26 MINOR VIRION PROTEIN

(Mimivirus-dependent
virus Sputnik) 		no annotation 4 ILE N 209
ARG N 185
TYR N 194
GLU N 192
 None
 1.28A 4zzcE-3j26N:
undetectable		 4zzcE-3j26N:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsa HOMOSERINE
DEHYDROGENASE

(Thermoplasma
volcanium) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 ILE A 201
ARG A 187
TYR A 178
GLU A 182
 None
SO4  A 502 (-3.7A)
None
None
 1.01A 4zzcE-3jsaA:
undetectable		 4zzcE-3jsaA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kje CO
DEHYDROGENASE/ACETYL
-COA SYNTHASE
COMPLEX, ACCESSORY
PROTEIN COOC

(Carboxydothermus
hydrogenoformans) 		PF01656
(CbiA) 		4 ILE A 161
ILE A 174
TYR A 188
GLU A 175
 None
 1.26A 4zzcE-3kjeA:
undetectable		 4zzcE-3kjeA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l39 PUTATIVE PHOU-LIKE
PHOSPHATE REGULATORY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01865
(PhoU_div) 		4 ILE A 107
ILE A 189
TYR A 108
GLU A 188
 None
None
None
PO4  A 217 (-4.3A)
 1.23A 4zzcE-3l39A:
7.8		 4zzcE-3l39A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldu PUTATIVE METHYLASE

(Clostridioides
difficile) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 ILE A  87
ARG A 231
TYR A 140
GLU A 138
 None
None
FMT  A 384 (-4.9A)
None
 1.28A 4zzcE-3lduA:
undetectable		 4zzcE-3lduA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naf CALCIUM-ACTIVATED
POTASSIUM CHANNEL
SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1

(Homo sapiens) 		PF03493
(BK_channel_a) 		4 ILE A 953
ARG A 938
TYR A 463
GLU A 488
 None
 1.18A 4zzcE-3nafA:
undetectable		 4zzcE-3nafA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		4 ILE A 989
ILE A 951
ARG A 325
GLU A 387
 None
 1.01A 4zzcE-3psiA:
undetectable		 4zzcE-3psiA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpm PEROXIREDOXIN

(Larimichthys
crocea) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 ILE A  83
ILE A 163
ARG A 128
GLU A 133
 None
 0.91A 4zzcE-3qpmA:
undetectable		 4zzcE-3qpmA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhg PUTATIVE
PHOPHOTRIESTERASE

(Proteus
mirabilis) 		PF02126
(PTE) 		4 ILE A 127
ILE A 167
TYR A 126
GLU A 166
 None
None
UNL  A 372 (-4.3A)
ZN  A 368 (-2.5A)
 1.05A 4zzcE-3rhgA:
undetectable		 4zzcE-3rhgA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s88 ENVELOPE
GLYCOPROTEIN

(Sudan
ebolavirus) 		PF01611
(Filo_glycop) 		4 ILE I  79
ARG I  85
TYR I 109
GLU I 178
 None
 1.25A 4zzcE-3s88I:
undetectable		 4zzcE-3s88I:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tts BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 ILE A 390
ARG A 650
TYR A 629
GLU A 673
 None
 1.29A 4zzcE-3ttsA:
undetectable		 4zzcE-3ttsA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uki OXYR

(Porphyromonas
gingivalis) 		PF03466
(LysR_substrate) 		4 ILE A 241
ARG A 230
TYR A 168
GLU A 233
 None
 1.28A 4zzcE-3ukiA:
undetectable		 4zzcE-3ukiA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 ILE B1437
ILE B1400
TYR B1389
GLU B1364
 None
 1.27A 4zzcE-3zefB:
undetectable		 4zzcE-3zefB:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4

(Mus musculus) 		PF00225
(Kinesin) 		4 ILE A 112
ILE A 119
TYR A 102
GLU A 193
 None
 1.17A 4zzcE-3zfcA:
undetectable		 4zzcE-3zfcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4

(Mus musculus) 		PF00225
(Kinesin) 		4 ILE A 262
ILE A 264
ARG A 212
GLU A 260
 None
 1.14A 4zzcE-3zfcA:
undetectable		 4zzcE-3zfcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2

(Homo sapiens) 		PF00753
(Lactamase_B) 		4 ILE A  86
ILE A 113
TYR A 121
GLU A 112
 None
 1.23A 4zzcE-4ad9A:
undetectable		 4zzcE-4ad9A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgv MALATE DEHYDROGENASE

(Picrophilus
torridus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ILE A   9
ILE A  35
TYR A  71
GLU A  68
 None
 1.13A 4zzcE-4bgvA:
undetectable		 4zzcE-4bgvA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Escherichia
coli) 		PF04378
(RsmJ) 		4 ILE A 241
ILE A 222
TYR A 196
GLU A 223
 None
 1.01A 4zzcE-4bluA:
undetectable		 4zzcE-4bluA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0n 2-ON-2 HEMOGLOBIN

(Arabidopsis
thaliana) 		PF01152
(Bac_globin) 		4 ILE A  68
ARG A  88
TYR A  72
GLU A  73
 None
 0.93A 4zzcE-4c0nA:
2.3		 4zzcE-4c0nA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 ILE A 391
ILE A 105
TYR A 251
GLU A 277
 None
 1.16A 4zzcE-4cntA:
undetectable		 4zzcE-4cntA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7l PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA

(Corynebacterium
diphtheriae) 		PF01625
(PMSR) 		4 ILE A  96
ARG A 136
TYR A 140
GLU A 175
 None
 1.14A 4zzcE-4d7lA:
undetectable		 4zzcE-4d7lA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER

(Escherichia
coli) 		PF13520
(AA_permease_2) 		4 ILE A 390
ARG A 401
TYR A 389
GLU A  63
 None
 1.23A 4zzcE-4djiA:
undetectable		 4zzcE-4djiA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 472
ARG A 599
TYR A 629
GLU A 600
 None
 1.22A 4zzcE-4f4pA:
2.0		 4zzcE-4f4pA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7l UNCHARACTERIZED
PROTEIN

(Planctopirus
limnophila) 		no annotation 4 ILE A 109
ILE A 112
TYR A  67
GLU A  65
 None
None
None
CU  A 201 (-2.4A)
 1.04A 4zzcE-4h7lA:
undetectable		 4zzcE-4h7lA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594

(Pyrococcus
horikoshii) 		PF00326
(Peptidase_S9)
PF07676
(PD40) 		4 ILE B 303
ILE B 296
TYR B 314
GLU B 332
 None
 1.18A 4zzcE-4hxeB:
undetectable		 4zzcE-4hxeB:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inq OXYSTEROL-BINDING
PROTEIN HOMOLOG 3

(Saccharomyces
cerevisiae) 		PF01237
(Oxysterol_BP) 		4 ILE A 907
ILE A 910
ARG A 984
GLU A 728
 None
 0.72A 4zzcE-4inqA:
undetectable		 4zzcE-4inqA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixk FERRITIN

(Pseudo-nitzschia
multiseries) 		PF00210
(Ferritin) 		4 ILE A 137
ILE A  90
TYR A  40
GLU A  44
 None
 0.75A 4zzcE-4ixkA:
5.5		 4zzcE-4ixkA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ILE A 122
ILE A 118
ARG A  10
TYR A 106
 None
 1.13A 4zzcE-4jr7A:
undetectable		 4zzcE-4jr7A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG

(Salmonella
enterica) 		PF03372
(Exo_endo_phos) 		4 ILE F 149
ARG F 129
TYR F 109
GLU F  92
 None
 1.24A 4zzcE-4k6lF:
undetectable		 4zzcE-4k6lF:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG

(Salmonella
enterica) 		PF03372
(Exo_endo_phos) 		4 ILE F 149
ILE F  81
TYR F 109
GLU F  92
 None
 1.10A 4zzcE-4k6lF:
undetectable		 4zzcE-4k6lF:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maa PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		4 ILE A 351
ILE A 359
TYR A 342
GLU A 349
 None
 1.29A 4zzcE-4maaA:
undetectable		 4zzcE-4maaA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om7 TOLL-LIKE RECEPTOR 6

(Homo sapiens) 		PF01582
(TIR) 		4 ILE A 777
ILE A 669
TYR A 663
GLU A 667
 None
 1.26A 4zzcE-4om7A:
undetectable		 4zzcE-4om7A:
20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN

(Homo sapiens;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 ILE A  73
ILE A  76
ARG A  85
TYR A 102
GLU A 104
 None
None
CL  A 502 (-4.3A)
None
None
 0.21A 4zzcE-4x5tA:
34.7		 4zzcE-4x5tA:
71.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8d SULFOXIDE SYNTHASE
EGTB

(Mycolicibacterium
thermoresistibile) 		PF03781
(FGE-sulfatase)
PF12867
(DinB_2) 		4 ILE A 223
ARG A 421
TYR A 228
GLU A 281
 None
 0.89A 4zzcE-4x8dA:
undetectable		 4zzcE-4x8dA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Homo sapiens) 		PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		4 ILE A 162
ILE A 154
TYR A 132
GLU A 153
 None
 1.23A 4zzcE-4xwhA:
5.5		 4zzcE-4xwhA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y2o CFA/I FIMBRIAL
SUBUNIT A
(COLONIZATION FACTOR
ANTIGEN SUBUNIT A
PUTATIVE CHAPERONE)

(Escherichia
coli) 		no annotation 4 ILE A  51
ILE A  39
TYR A  89
GLU A  87
 None
 1.20A 4zzcE-4y2oA:
undetectable		 4zzcE-4y2oA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlh LIPOPOLYSACCHARIDE
ASSEMBLY PROTEIN B

(Escherichia
coli) 		PF14559
(TPR_19) 		4 ILE A 305
ILE A 292
TYR A 324
GLU A 293
 None
 1.22A 4zzcE-4zlhA:
3.0		 4zzcE-4zlhA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee0 OBG-LIKE ATPASE 1

(Oryza sativa) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		4 ILE A 122
ARG A 202
TYR A 227
GLU A 257
 None
 1.17A 4zzcE-5ee0A:
2.5		 4zzcE-5ee0A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		4 ILE A 623
ILE A 663
TYR A 620
GLU A 661
 None
 1.25A 4zzcE-5ezrA:
undetectable		 4zzcE-5ezrA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai PORTAL PROTEIN

(Salmonella
virus P22) 		PF16510
(P22_portal) 		4 ILE A 298
ILE A 293
TYR A 223
GLU A 221
 None
 0.98A 4zzcE-5gaiA:
undetectable		 4zzcE-5gaiA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hwq HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Myxococcus
xanthus) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 ILE A  21
ILE A 378
ARG A  28
GLU A 156
 None
 1.24A 4zzcE-5hwqA:
undetectable		 4zzcE-5hwqA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb PROTEIN CEREBLON

(Homo sapiens) 		no annotation 4 ILE Z  92
ILE Z  90
ARG Z 419
GLU Z 358
 None
 1.21A 4zzcE-5hxbZ:
undetectable		 4zzcE-5hxbZ:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqk PEPTIDASE, PUTATIVE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		4 ILE A 768
ARG A 505
TYR A 764
GLU A 502
 None
 1.10A 4zzcE-5jqkA:
undetectable		 4zzcE-5jqkA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyo CYP101J2

(Sphingobium
yanoikuyae) 		PF00067
(p450) 		4 ILE A 243
ILE A 245
ARG A 203
GLU A 241
 None
 1.13A 4zzcE-5kyoA:
2.1		 4zzcE-5kyoA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT
ACETOPHENONE
CARBOXYLASE BETA
SUBUNIT

(Aromatoleum
aromaticum;
Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B)
PF08882
(Acetone_carb_G) 		4 ILE A 614
ARG C  45
TYR A 514
GLU C  72
 None
 1.19A 4zzcE-5l9wA:
undetectable		 4zzcE-5l9wA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2g DNA POLYMERASE

(Vaccinia virus) 		no annotation 4 ILE A 327
ILE A   6
TYR A 258
GLU A 476
 MES  A1103 ( 4.9A)
None
None
None
 1.26A 4zzcE-5n2gA:
2.5		 4zzcE-5n2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncw SERPIN-TYPE
PROTEINASE
INHIBITOR, MIROPIN

(Tannerella
forsythia) 		PF00079
(Serpin) 		4 ILE A 129
ARG A 303
TYR A 155
GLU A 326
 None
CL  A 508 (-3.2A)
None
None
 1.04A 4zzcE-5ncwA:
undetectable		 4zzcE-5ncwA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncw SERPIN-TYPE
PROTEINASE
INHIBITOR, MIROPIN

(Tannerella
forsythia) 		PF00079
(Serpin) 		4 ILE A 305
ARG A 303
TYR A 155
GLU A 326
 None
CL  A 508 (-3.2A)
None
None
 1.22A 4zzcE-5ncwA:
undetectable		 4zzcE-5ncwA:
21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5osb PROTON-GATED ION
CHANNEL,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Mus musculus;
Gloeobacter
violaceus) 		no annotation 5 ILE A  72
ILE A  75
ARG A  84
TYR A 101
GLU A 103
 None
None
CL  A 504 (-4.7A)
None
None
 0.39A 4zzcE-5osbA:
34.2		 4zzcE-5osbA:
70.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		no annotation 4 ILE B 310
ILE B 536
ARG B 382
GLU B 166
 None
 1.20A 4zzcE-5txrB:
undetectable		 4zzcE-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA

(Bdellovibrio
bacteriovorus) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 ILE A   4
ARG A 356
TYR A 364
GLU A 333
 None
 1.16A 4zzcE-5ur2A:
2.2		 4zzcE-5ur2A:
16.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v6n PROTON-GATED ION
CHANNEL

(Gloeobacter
violaceus) 		no annotation 5 ILE C  73
ILE C  76
ARG C  85
TYR C 102
GLU C 104
 None
 0.59A 4zzcE-5v6nC:
36.2		 4zzcE-5v6nC:
98.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wql TAIL-SPECIFIC
PROTEASE

(Escherichia
coli) 		no annotation 4 ILE C 588
ARG C 448
TYR C 655
GLU C 472
 None
 1.10A 4zzcE-5wqlC:
undetectable		 4zzcE-5wqlC:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1t PPKA-294

(Serratia sp.
FS14) 		no annotation 4 ILE A  51
ILE A  36
ARG A  62
TYR A 115
 None
 1.13A 4zzcE-5x1tA:
undetectable		 4zzcE-5x1tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1a -

(-) 		no annotation 4 ILE A 190
ARG A  93
TYR A 162
GLU A  20
 None
 0.83A 4zzcE-5y1aA:
undetectable		 4zzcE-5y1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d04 RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 4 ILE E 327
ARG E 207
TYR E 430
GLU E 204
 None
 1.24A 4zzcE-6d04E:
3.8		 4zzcE-6d04E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN

(Xanthomonas
campestris) 		no annotation 4 ILE A 125
ARG A  30
TYR A 101
GLU A  29
 None
 0.69A 4zzcE-6ei3A:
2.1		 4zzcE-6ei3A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g1o -

(-) 		no annotation 4 ILE A 171
ARG A 156
TYR A   4
GLU A  28
 None
 1.25A 4zzcE-6g1oA:
undetectable		 4zzcE-6g1oA:
undetectable