SIMILAR PATTERNS OF AMINO ACIDS FOR 4ZZC_C_ACTC401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqu BETA-FRUCTOFURANOSID
ASE

(Arabidopsis
thaliana) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 PHE A 491
ARG A 480
ILE A 318
GLU A 489
 None
 1.48A 4zzcC-2qquA:
0.0
4zzcD-2qquA:
0.0		 4zzcC-2qquA:
21.68
4zzcD-2qquA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cuq VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 36

(Homo sapiens) 		PF04157
(EAP30) 		4 PHE B 306
ARG B 304
ILE B 263
GLU B 320
 None
 1.44A 4zzcC-3cuqB:
0.0
4zzcD-3cuqB:
0.0		 4zzcC-3cuqB:
21.12
4zzcD-3cuqB:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec7 PUTATIVE
DEHYDROGENASE

(Salmonella
enterica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 PHE A 283
ARG A  20
ILE A  13
GLU A  96
 None
None
NAD  A 400 (-4.1A)
NAD  A 400 (-2.9A)
 1.35A 4zzcC-3ec7A:
0.0
4zzcD-3ec7A:
0.0		 4zzcC-3ec7A:
20.26
4zzcD-3ec7A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ARG A 345
ARG A 428
ILE A 424
GLU A 398
 None
 0.89A 4zzcC-3hdxA:
1.1
4zzcD-3hdxA:
1.1		 4zzcC-3hdxA:
20.95
4zzcD-3hdxA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX

(Thermus
thermophilus) 		PF02629
(CoA_binding)
PF06971
(Put_DNA-bind_N) 		4 ARG A 140
ARG A 108
ILE A 141
GLU A 142
 None
 1.34A 4zzcC-3il2A:
0.0
4zzcD-3il2A:
0.0		 4zzcC-3il2A:
22.69
4zzcD-3il2A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Trypanosoma
brucei) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 PHE A 379
ARG A 417
ILE A 348
GLU A 377
 None
 1.26A 4zzcC-3nvlA:
1.2
4zzcD-3nvlA:
1.2		 4zzcC-3nvlA:
20.97
4zzcD-3nvlA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4are COLLAGENASE G

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		4 PHE A 515
ARG A 573
ILE A 576
GLU A 559
 None
 1.43A 4zzcC-4areA:
1.7
4zzcD-4areA:
1.7		 4zzcC-4areA:
19.15
4zzcD-4areA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fem OUTER MEMBRANE
PROTEIN SUSE

(Bacteroides
thetaiotaomicron) 		PF16411
(SusF_SusE) 		4 PHE A 352
ARG A 350
ILE A 355
GLU A 360
 None
 1.33A 4zzcC-4femA:
0.4
4zzcD-4femA:
0.4		 4zzcC-4femA:
21.25
4zzcD-4femA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01558
(POR)
PF01855
(POR_N) 		4 ARG A   2
ARG A 603
ILE A 532
GLU A 607
 None
 1.35A 4zzcC-5b48A:
0.0
4zzcD-5b48A:
0.0		 4zzcC-5b48A:
21.28
4zzcD-5b48A:
21.28